12-2949-41

antibody from Invitrogen Antibodies

Targeting: PTGDR2 CD294, CRTH2, DP2, GPR44

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

12-2949-41

Provider

Invitrogen Antibodies

Product name

CD294 (CRTH2) Monoclonal Antibody (BM16), PE, eBioscience™

Antibody type

Monoclonal

Antigen

Other

Description

Description: This BM16 monoclonal antibody reacts with human CD294, which is also known as G protein-coupled receptor-44 (GPR-44) or chemoattractant receptor expressed on Th2 cells (CRTH2). CD294 is expressed on Th2 cells, some CD8+ cells, eosinophils, and basophils. Moreover, CD294 binds prostaglandin D2, which promotes leukocyte chemotaxis during allergic responses. CD294 has been reported to mediate prostaglandin D2-mediated suppression of apoptosis of Th2 cells by activating the PI3K pathway.

Conjugate

Yellow dye

Antibody clone number

BM16

Concentration

5 µL/Test

References

Submitted references

Effects of myeloid and plasmacytoid dendritic cells on ILC2s in patients with allergic rhinitis.

Peng YQ, Qin ZL, Fang SB, Xu ZB, Zhang HY, Chen D, Liu Z, Bellanti JA, Zheng SG, Fu QL
The Journal of allergy and clinical immunology 2020 Mar;145(3):855-867.e8

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Expansion of Group 2 Innate Lymphoid Cells in Patients with End-Stage Renal Disease and Their Clinical Significance.

Liu GY, Deng XH, Li X, Cao YJ, Xing YF, Zhou P, Lei AH, Yang Q, Deng K, Zhang H, Zhou J
Journal of immunology (Baltimore, Md. : 1950) 2020 Jul 1;205(1):36-44

Flow cytometry

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Staining of normal human peripheral blood cells with Anti-Human CD123 FITC (Product # 11-1239-42) and Rat IgG2a K Isotype Control PE (Product # 12-4321-80) (left) or Anti-Human CD294 (CRTH2) PE (right). Cells in the lymphocyte gate were used for analysis.

Conjugate

Yellow dye