Antibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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- Product number
- 50-2949-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD294 (CRTH2) Monoclonal Antibody (BM16), eFluor™ 660, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This BM16 monoclonal antibody reacts with human CD294, which is also known as G protein-coupled receptor-44 (GPR-44) or chemoattractant receptor expressed on Th2 cells (CRTH2). CD294 is expressed on Th2 cells, some CD8+ cells, eosinophils, and basophils. Moreover, CD294 binds prostaglandin D2, which promotes leukocyte chemotaxis during allergic responses. CD294 has been reported to mediate prostaglandin D2-mediated suppression of apoptosis of Th2 cells by activating the PI3K pathway.
- Antibody clone number
- BM16
- Concentration
- 5 µL/Test
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- Staining of normal human peripheral blood cells with Anti-Human CD123 FITC (Product # 11-1239-42) and Rat IgG2a K Isotype Control eFluor® 660 (Product # 50-4321-82) (left) or Anti-Human CD294 (CRTH2) eFluor® 660 (Alexa Fluor® 647 Replacement) (right). Cells in the lymphocyte gate were used for analysis.