BHLHE23

This gene encodes a member of the basic helix-loop-helix transcription factor family. Members of this family contain two highly conserved and functionally distinct domains: the basic domain targets sequence-specific DNA binding, while the helix-loop-helix domain facilitates protein interaction. Studies of a related gene in mouse suggest that the encoded protein may function as a transcriptional repressor in the pancreas and brain, and that it is required for normal retinal function. [provided by RefSeq, May 2013]

Description

Basic helix-loop-helix family member e23

Tissue specificity

Tissue enriched (brain)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Transcription factors

Chromosome

20 (63005927 - 63007035)

Ensembl ID

ENSG00000125533  (ver. 103.38)

Orthologs

Mouse Bhlhe23: ENSMUSG00000045493

UniProt

Q8NDY6

neXtProt

NX_Q8NDY6

Human splice variants
Mouse splice variants

Protein structure