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- References [19]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 17737-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17737-1-AP, RRID:AB_10665813
- Product name
- EDC4 antibody
- Antibody type
- Polyclonal
- Description
- EDC4 antibody (Cat. #17737-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references tRNA synthetase activity is required for stress granule and P-body assembly.
NSCLC cells sustain phase separation of cytoplasmic membrane-less organelles to protect themselves against cisplatin treatment.
The molecular axis hnRNPU/circKCNK2/EDC4/IL-11 aggravates osteolytic bone metastasis of RCC.
A protein-proximity screen reveals Ebola virus co-opts the mRNA decapping complex through the scaffold protein EDC4.
EDC4 enhances multi-drug chemosensitivity in pancreatic cancer via GR50-based profiling.
Systematic characterization of the composition and dynamics of processing body-associated mRNAs.
Insight into the function of the Golgi membrane protein GOLM1 in cholangiocytes through interactomic analysis.
The RNA-Binding Protein IGF2BP1 Marks Germ Cells but Is Dispensable for Mouse Fertility.
CCHCR1 links P-body proteins to the centrosome and is required for ciliogenesis through interacting with OFD1 and PCM1.
Pooled CRISPR Screening Identifies P-Bodies as Repressors of Cancer Epithelial-Mesenchymal Transition.
DDX6 modulates P-body and stress granule assembly, composition, and docking.
LSM14B coordinates protein component expression in the P-body and controls oocyte maturation.
A protein-proximity screen reveals Ebola virus co-opts the mRNA decapping complex through the scaffold protein EDC4.
O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins.
Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method.
NUSAP1 regulates mouse oocyte meiotic maturation.
QKI degradation in macrophage by RNF6 protects mice from MRSA infection via enhancing PI3K p110β dependent autophagy.
The RNA binding protein QKI5 suppresses ovarian cancer via downregulating transcriptional coactivator TAZ.
Gemin5 plays a role in unassembled-U1 snRNA disposal in SMN-deficient cells.
Baymiller M, Helton NS, Dodd B, Moon SL
Genes & development 2026 Apr 1;40(7-8):475-497
Genes & development 2026 Apr 1;40(7-8):475-497
NSCLC cells sustain phase separation of cytoplasmic membrane-less organelles to protect themselves against cisplatin treatment.
Li NN, Rao LL, Su D, Liu BH, Ma GQ, Wang HF, Zhang ZL, Ying Z
Acta pharmacologica Sinica 2025 Sep;46(9):2522-2533
Acta pharmacologica Sinica 2025 Sep;46(9):2522-2533
The molecular axis hnRNPU/circKCNK2/EDC4/IL-11 aggravates osteolytic bone metastasis of RCC.
Wang Y, Zhao D, Lu J, Hou N, Wu Q, Zhou S, Xu J, Xue W, Cui W, Zheng J, Wang F, Zhai W
Oncogene 2025 Sep;44(36):3310-3332
Oncogene 2025 Sep;44(36):3310-3332
A protein-proximity screen reveals Ebola virus co-opts the mRNA decapping complex through the scaffold protein EDC4.
Donahue CJ, Kesari AS, Thakur N, Wang L, Stubbs SH, Williams CG, Sharma SB, Kirby CD, Leung DW, Aryal UK, Basler CF, LaCount DJ, Davey RA
Nature communications 2025 Sep 26;16(1):8485
Nature communications 2025 Sep 26;16(1):8485
EDC4 enhances multi-drug chemosensitivity in pancreatic cancer via GR50-based profiling.
Qin C, Li T, Zhao B, Li Z, Zhao Y, Zhang X, Xie Y, Yan Y, Han J, Shao Q, Lin C, Wang W
Cancer cell international 2025 Oct 10;25(1):347
Cancer cell international 2025 Oct 10;25(1):347
Systematic characterization of the composition and dynamics of processing body-associated mRNAs.
Sun Z, Wen X, Li Y, Xie X, Dong P, Shu Y, Tian S, Yang J, Lin Y, Wang M, Jiang F, Zhu Q, Cui H, Zhai J, Hu Y, Fang L, Chen W
Nature communications 2025 Nov 10;16(1):9867
Nature communications 2025 Nov 10;16(1):9867
Insight into the function of the Golgi membrane protein GOLM1 in cholangiocytes through interactomic analysis.
Nagaraj M, Emmagouni SKG, Chaurasiya V, Li L, Nguyen VD, Keskitalo S, Varjosalo M, Zhou Y, Haridas PAN, Olkkonen VM
FEBS letters 2025 May;599(9):1299-1316
FEBS letters 2025 May;599(9):1299-1316
The RNA-Binding Protein IGF2BP1 Marks Germ Cells but Is Dispensable for Mouse Fertility.
Wang S, Wu S, Tang J, Chen Y, Zhang Y, Long W, Wu X
Molecular reproduction and development 2025 Feb;92(2):e70016
Molecular reproduction and development 2025 Feb;92(2):e70016
CCHCR1 links P-body proteins to the centrosome and is required for ciliogenesis through interacting with OFD1 and PCM1.
Zhang J, Wu Q, Zhang S, Sze SCW, Li C
Cellular & molecular biology letters 2025 Aug 29;30(1):103
Cellular & molecular biology letters 2025 Aug 29;30(1):103
Pooled CRISPR Screening Identifies P-Bodies as Repressors of Cancer Epithelial-Mesenchymal Transition.
Fang L, Zhang L, Wang M, He Y, Yang J, Huang Z, Tan Y, Fang K, Li J, Sun Z, Li Y, Tang Y, Liang W, Cui H, Zhu Q, Wu Z, Li Y, Hu Y, Chen W
Cancer research 2024 Mar 4;84(5):659-674
Cancer research 2024 Mar 4;84(5):659-674
DDX6 modulates P-body and stress granule assembly, composition, and docking.
Ripin N, Macedo de Vasconcelos L, Ugay DA, Parker R
The Journal of cell biology 2024 Jun 3;223(6)
The Journal of cell biology 2024 Jun 3;223(6)
LSM14B coordinates protein component expression in the P-body and controls oocyte maturation.
Zhang H, Zhang T, Wan X, Chen C, Wang S, Qin D, Li L, Yu L, Wu X
Journal of genetics and genomics = Yi chuan xue bao 2024 Jan;51(1):48-60
Journal of genetics and genomics = Yi chuan xue bao 2024 Jan;51(1):48-60
A protein-proximity screen reveals Ebola virus co-opts the mRNA decapping complex through the scaffold protein EDC4.
Davey R, Donahue C, Kesari A, Thakur N, Wang L, Hulsey-Stubbs S, Williams C, Kirby C, Leung D, Aryal U, Basler C, LaCount D
Research square 2024 Feb 2;
Research square 2024 Feb 2;
O-GlcNAcylation determines the translational regulation and phase separation of YTHDF proteins.
Chen Y, Wan R, Zou Z, Lao L, Shao G, Zheng Y, Tang L, Yuan Y, Ge Y, He C, Lin S
Nature cell biology 2023 Nov;25(11):1676-1690
Nature cell biology 2023 Nov;25(11):1676-1690
Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method.
Carden S, Vitiello E, Rosa E Silva I, Holder J, Quarantotti V, Kishore K, Roamio Franklin VN, D'Santos C, Ochi T, van Breugel M, Gergely F
Developmental cell 2023 Nov 6;58(21):2393-2410.e9
Developmental cell 2023 Nov 6;58(21):2393-2410.e9
NUSAP1 regulates mouse oocyte meiotic maturation.
Yu L, Kong N, Lin Y, Qiu P, Xu Q, Zhang Y, Zhen X, Yan G, Sun H, Mei J, Cao G
Journal of cellular biochemistry 2023 Dec;124(12):1931-1947
Journal of cellular biochemistry 2023 Dec;124(12):1931-1947
QKI degradation in macrophage by RNF6 protects mice from MRSA infection via enhancing PI3K p110β dependent autophagy.
Zhai D, Wang W, Ye Z, Xue K, Chen G, Hu S, Yan Z, Guo Y, Wang F, Li X, Xiang A, Li X, Lu Z, Wang L
Cell & bioscience 2022 Sep 10;12(1):154
Cell & bioscience 2022 Sep 10;12(1):154
The RNA binding protein QKI5 suppresses ovarian cancer via downregulating transcriptional coactivator TAZ.
Liu T, Yang Y, Xie Z, Luo Q, Yang D, Liu X, Zhao H, Wei Q, Liu Y, Li L, Wang Y, Wang F, Yu J, Xu J, Yu J, Yi P
Molecular therapy. Nucleic acids 2021 Dec 3;26:388-400
Molecular therapy. Nucleic acids 2021 Dec 3;26:388-400
Gemin5 plays a role in unassembled-U1 snRNA disposal in SMN-deficient cells.
Jiang D, Zou X, Zhang C, Chen J, Li Z, Wang Y, Deng Z, Wang L, Chen S
FEBS letters 2018 Apr;592(8):1400-1411
FEBS letters 2018 Apr;592(8):1400-1411
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 17737-1-AP(EDC4 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver cancer using 17737-1-AP(EDC4 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The EDC4 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human EDC4. This antibody recognizes human,mouse,rat antigen. The EDC4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
