RA0057

antibody from Oursmab

Targeting: C5AR1 C5A, C5AR, C5R1, CD88

Western blot (Supportive data in Antibodypedia)

ELISA (Supportive data in Antibodypedia)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0057

Provider

Oursmab

Product name

Izastobart (Biosimilar Reference Antibody) (C5AR1)

Antibody type

Monoclonal

Description

Izastobart is a humanized IgG1¦Ë2 monoclonal antibody that specifically targets the C5a receptor 1 (C5aR1 or CD88). As an IgG1 isotype, it is engineered to potentially engage effector functions such as antibody-dependent cellular cytotoxicity (ADCC). Its primary mechanism is to block the interaction between the complement anaphylatoxin C5a and its receptor C5aR1. By inhibiting this potent pro-inflammatory signaling axis, Izastobart aims to dampen the dysregulated complement activity and neutrophil-driven inflammation that are central to the pathology of autoimmune and inflammatory diseases. It is currently under clinical investigation for conditions such as hidradenitis suppurativa.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

Western blot

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

Izastobart (Biosimilar Reference Antibody) (C5AR1)-RA0057-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.

ELISA

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

ELISA plate pre-coated Antigen protein, can bind Izastobart (Biosimilar Reference Antibody) (C5AR1)-RA0057 in a linear range of 0.18¨C15 ng/mL.