Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations [0]
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- Product number
- 335303 - Provider product page
- Provider
- BioLegend
- Product name
- PerCP/Cy5.5 anti-human CD192 (CCR2)
- Antibody type
- Monoclonal
- Antigen
- CCR2 transfectants
- Description
- CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, 2, 3 and 4). Two spliced variants were initially described for CCR2 (CCR2A and CCR2B). These variants differ in their terminal carboxyl tails (1). Monocyte adhesion to the arterial endothelium and subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. CCR2 and MCP-1 has been associated to atheroscletotic plaques (2, 3). MCP-1 is induced by modified-LDL in endothelial cells, and may trigger firm adhesion of monocytes to vascular endothelium under flow. Local overexpression of MCP-1 at vessel wall induces infiltration of macrophages and formation of atherosclerotic lesion (4). Absence of MCP-1 reduces the lesion size in MCP-1−/− apoE−/− mice in the apoE gene deleted mouse atherosclerosis model (5, 6). Obesity induces an inflammation state that is implicated in many clinically important complications, including insulin resistance, diabetes, atherosclerosis and non-alcoholic fatty liver disease. CCR2 influences the development of obesity and associated adipose tissue inflammation (7).
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Far-Red dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The CD192 antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Nutrient modification of the innate immune response: a novel mechanism by which saturated fatty acids greatly amplify monocyte inflammation.
Schwartz EA, Zhang WY, Karnik SK, Borwege S, Anand VR, Laine PS, Su Y, Reaven PD
Arteriosclerosis, thrombosis, and vascular biology 2010 Apr;30(4):802-8
Arteriosclerosis, thrombosis, and vascular biology 2010 Apr;30(4):802-8
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