Ab169252

antibody from Aladdin Scientific

Targeting: CCR5 CC-CKR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22

No application information provided.

Antibody Data

Product number

Ab169252

Provider

Aladdin Scientific

Product name

Leronlimab (anti-CCR5)

Antibody type

Recombinant

Description

Leronlimab (anti-CCR5) is a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy. It is being investigated as a potential therapy in the treatment of HIV infection.In vitroLeronlimab binds CCR5 in multiple breast cancer cell lines, reducing ligand-induced Ca2+ signaling, invasion of TNBC into Matrigel, and transwell migration, also enhances the breast cancer (BCa) cell killing of the BCa chemotherapy reagent, doxorubicin.In vivoIn xenografts conducted with Nu/Nu mice, leronlimab reduces lung metastasis of the TNBC cell line, MB-MDA-231, reducing the metastatic tumor burden of established TNBC lung metastasis. Purity>95% (SDS-PAGE&SEC)Endotoxin Level< 1.0EU/mg

Reactivity

Human

Conjugate

Unconjugated

Vial size

100_g,10mg,1mg,5mg

Concentration

Lot by Lot

Storage

Store at -80_ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.