RA0066

antibody from Oursmab

Targeting: CCR5 CC-CKR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22

Western blot (Data presented on provider website)

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0066

Provider

Oursmab

Product name

Leronlimab (Biosimilar Reference Antibody) (CCR5)

Antibody type

Monoclonal

Description

Leronlimab (also known as PRO 140) is a humanized IgG4 monoclonal antibody that functions as a CCR5 antagonist. It selectively binds to the CCR5 chemokine receptor on the surface of CD4+ T cells and other immune cells, blocking its interaction with natural ligands and, most critically, with the human immunodeficiency virus (HIV-1) envelope glycoprotein gp120. This blockade prevents the viral entry step that is dependent on the CCR5 co-receptor. It has been developed as a long-acting (weekly subcutaneous) antiretroviral therapy for CCR5-tropic HIV-1 infection, showing efficacy in treatment-experienced patients. It has also been investigated for other conditions where CCR5 plays a role, such as metastatic cancer and COVID-19, though clinical benefit in these areas remains unconfirmed.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.