BS7781

antibody from Bioworld Technology, Inc
Targeting: PSMB10 beta2i, LMP10, MECL1, MGC1665
Provider product page for BS7781
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS7781 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PSMB10 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human PSMB10.
Description
The 20S proteasome is a protease complex that is responsible for cytosolic protein degradation and generation of peptide ligands for major histocompatabilty complex (MHC) class I molecules, either in their final form or in the form of amino-terminally extended precursors. Upon IFN-gamma stimulation of cells, three constitutively expressed subunits of the 20S proteasome are replaced by inducible subunits LMP2 (low-molecular mass polypeptide 2), LMP7, and MECL-1 (multicatalytic endopeptidase complex-like-1, LMP10). LMP2, LMP7, and MECL-1 subunits form immunoproteasomes, which are associated with more efficient class I antigen processing and presentation. Independent assortment of LMP-2, LMP-7, and MECL-1 into different proteasome complexes can lead to 36 unique proteasome subsets, which may mediate differences in the cleavage specificities/cleavage motifs of proteins subject to constitutive- and immuno-proteasomes.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PSMB10 protein structure - BS7781 shown in red.