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- Antigen structure
- References [7]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- 21346-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21346-1-AP, RRID:AB_10733238
- Product name
- Sestrin 2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Sestrin 2 antibody (Cat. #21346-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Metastatic Melanoma Cells Rely on Sestrin2 to Acquire Anoikis Resistance via Detoxifying Intracellular ROS.
MiR-4756 promotes albumin-induced renal tubular epithelial cell epithelial-to-mesenchymal transition and endoplasmic reticulum stress via targeting Sestrin2.
p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.
Sestrin2, as a negative feedback regulator of mTOR, provides neuroprotection by activation AMPK phosphorylation in neonatal hypoxic-ischemic encephalopathy in rat pups.
Dynamics of mTORC1 activation in response to amino acids.
Sestrin2 induced by hypoxia inducible factor1 alpha protects the blood-brain barrier via inhibiting VEGF after severe hypoxic-ischemic injury in neonatal rats.
Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.
Zhu G, Xu P, Guo S, Yi X, Wang H, Yang Y, Liu L, Shi Q, Gao T, Li C
The Journal of investigative dermatology 2020 Mar;140(3):666-675.e2
The Journal of investigative dermatology 2020 Mar;140(3):666-675.e2
MiR-4756 promotes albumin-induced renal tubular epithelial cell epithelial-to-mesenchymal transition and endoplasmic reticulum stress via targeting Sestrin2.
Jia Y, Zheng Z, Yang Y, Zou M, Li J, Wang L, Guan M, Xue Y
Journal of cellular physiology 2019 Mar;234(3):2905-2915
Journal of cellular physiology 2019 Mar;234(3):2905-2915
p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.
Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson FS, Tepper J, Chen Z, Lovisa S, Svelto M, Amin S, Srinivasan S, Del Poggetto E, Loponte S, Puca F, Dey P, Malouf GG, Su X, Li L, Lopez-Terrada D, Rakheja D, Lazar AJ, Netto GJ, Rao P, Sgambato A, Maitra A, Tripathi DN, Walker CL, Karam JA, Heffernan TP, Viale A, Roberts CWM, Msaouel P, Tannir NM, Draetta GF, Genovese G
Cancer cell 2019 Feb 11;35(2):204-220.e9
Cancer cell 2019 Feb 11;35(2):204-220.e9
Sestrin2, as a negative feedback regulator of mTOR, provides neuroprotection by activation AMPK phosphorylation in neonatal hypoxic-ischemic encephalopathy in rat pups.
Shi X, Xu L, Doycheva DM, Tang J, Yan M, Zhang JH
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2017 Apr;37(4):1447-1460
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2017 Apr;37(4):1447-1460
Dynamics of mTORC1 activation in response to amino acids.
Manifava M, Smith M, Rotondo S, Walker S, Niewczas I, Zoncu R, Clark J, Ktistakis NT
eLife 2016 Oct 11;5
eLife 2016 Oct 11;5
Sestrin2 induced by hypoxia inducible factor1 alpha protects the blood-brain barrier via inhibiting VEGF after severe hypoxic-ischemic injury in neonatal rats.
Shi X, Doycheva DM, Xu L, Tang J, Yan M, Zhang JH
Neurobiology of disease 2016 Nov;95:111-21
Neurobiology of disease 2016 Nov;95:111-21
Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.
Hou YS, Guan JJ, Xu HD, Wu F, Sheng R, Qin ZH
Molecular and cellular biology 2015 Aug;35(16):2740-51
Molecular and cellular biology 2015 Aug;35(16):2740-51
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse thymus tissue were subjected to SDS PAGE followed by western blot with 21346-1-AP(SESN2 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using SESN2 antibody 21346-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
