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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [16]
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- Product number
- 66297-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- Sestrin 2 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated Sestrin 2 antibody (Cat. #66297-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, pig, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Rat, Porcine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1A1A4
- Vial size
- 20ul, 150ul
Submitted references FTO-mediated autophagy inhibition promotes non-small cell lung cancer progression by reducing the stability of SESN2 mRNA.
Lysine specific demethylase 1 inhibits sodium arsenite activation of HSCs by regulating SESN2/AMPK/ULK1 signaling pathway activity.
Melatonin Ameliorates Ovarian Hyperstimulation Syndrome (OHSS) through SESN2 Regulated Antiapoptosis.
Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration.
Dysregulated Amino Acid Sensing Drives Colorectal Cancer Growth and Metabolic Reprogramming Leading to Chemoresistance.
Induction of Sestrin2 by pterostilbene suppresses ethanol-triggered hepatocyte senescence by degrading CCN1 via p62-dependent selective autophagy.
Resveratrol Promotes Gluconeogenesis by Inhibiting SESN2-mTORC2-AKT Pathway in Calf Hepatocytes.
POU Domain Class 2 Transcription Factor 2 Inhibits Ferroptosis in Cerebral Ischemia Reperfusion Injury by Activating Sestrin2.
Tanshinone IIA Regulates Keap1/Nrf2 Signal Pathway by Activating Sestrin2 to Restrain Pulmonary Fibrosis.
Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy.
Sestrin2 induction contributes to anti-inflammatory responses and cell survival by globular adiponectin in macrophages.
Intermittent Bolus Compared With Continuous Feeding Enhances Insulin and Amino Acid Signaling to Translation Initiation in Skeletal Muscle of Neonatal Pigs.
Prematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs.
Effect of atorvastatin on Aβ(1-42) -induced alteration of SESN2, SIRT1, LC3II and TPP1 protein expressions in neuronal cell cultures.
Sestrin2 alleviates palmitate-induced endoplasmic reticulum stress, apoptosis, and defective invasion of human trophoblast cells.
Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism.
Wang K, Mei Z, Zheng M, Liu X, Li D, Wang H
Heliyon 2024 Mar 15;10(5):e27571
Heliyon 2024 Mar 15;10(5):e27571
Lysine specific demethylase 1 inhibits sodium arsenite activation of HSCs by regulating SESN2/AMPK/ULK1 signaling pathway activity.
Zhang Y, Tian T, Liang C, Wang J, Zhang J, Tian S, Xie R, Yang T, Han B
Environmental toxicology 2024 Jun;39(6):3563-3577
Environmental toxicology 2024 Jun;39(6):3563-3577
Melatonin Ameliorates Ovarian Hyperstimulation Syndrome (OHSS) through SESN2 Regulated Antiapoptosis.
Zheng M, Liu M, Zhang C
Obstetrics and gynecology international 2023;2023:1121227
Obstetrics and gynecology international 2023;2023:1121227
Sesn2 Serves as a Regulator between Mitochondrial Unfolded Protein Response and Mitophagy in Intervertebral Disc Degeneration.
Xu WN, Liu C, Zheng HL, Xu HX, Yang RZ, Jiang SD, Zhu LX
International journal of biological sciences 2023;19(2):571-592
International journal of biological sciences 2023;19(2):571-592
Dysregulated Amino Acid Sensing Drives Colorectal Cancer Growth and Metabolic Reprogramming Leading to Chemoresistance.
Solanki S, Sanchez K, Ponnusamy V, Kota V, Bell HN, Cho CS, Kowalsky AH, Green M, Lee JH, Shah YM
Gastroenterology 2023 Mar;164(3):376-391.e13
Gastroenterology 2023 Mar;164(3):376-391.e13
Induction of Sestrin2 by pterostilbene suppresses ethanol-triggered hepatocyte senescence by degrading CCN1 via p62-dependent selective autophagy.
Jiang Y, Zhou Y, Xu W, Wang X, Jin H, Bao X, Lu C
Cell biology and toxicology 2023 Jun;39(3):729-749
Cell biology and toxicology 2023 Jun;39(3):729-749
Resveratrol Promotes Gluconeogenesis by Inhibiting SESN2-mTORC2-AKT Pathway in Calf Hepatocytes.
Wang G, Qin S, Geng H, Zheng Y, Li R, Xia C, Chen L, Yao J, Deng L
The Journal of nutrition 2023 Jul;153(7):1930-1943
The Journal of nutrition 2023 Jul;153(7):1930-1943
POU Domain Class 2 Transcription Factor 2 Inhibits Ferroptosis in Cerebral Ischemia Reperfusion Injury by Activating Sestrin2.
Yang J, Guo Q, Wang L, Yu S
Neurochemical research 2023 Feb;48(2):658-670
Neurochemical research 2023 Feb;48(2):658-670
Tanshinone IIA Regulates Keap1/Nrf2 Signal Pathway by Activating Sestrin2 to Restrain Pulmonary Fibrosis.
Li H, Wu M, Guo C, Zhai R, Chen J
The American journal of Chinese medicine 2022;50(8):2125-2151
The American journal of Chinese medicine 2022;50(8):2125-2151
Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy.
Bian Y, Shi C, Song S, Mu L, Wu M, Qiu D, Dong J, Zhang W, Yuan C, Wang D, Zhou Z, Dong X, Shi Y
Cell and tissue research 2022 Oct;390(1):93-112
Cell and tissue research 2022 Oct;390(1):93-112
Sestrin2 induction contributes to anti-inflammatory responses and cell survival by globular adiponectin in macrophages.
Lee S, Pham DV, Park PH
Archives of pharmacal research 2022 Jan;45(1):38-50
Archives of pharmacal research 2022 Jan;45(1):38-50
Intermittent Bolus Compared With Continuous Feeding Enhances Insulin and Amino Acid Signaling to Translation Initiation in Skeletal Muscle of Neonatal Pigs.
Suryawan A, El-Kadi SW, Nguyen HV, Fiorotto ML, Davis TA
The Journal of nutrition 2021 Sep 4;151(9):2636-2645
The Journal of nutrition 2021 Sep 4;151(9):2636-2645
Prematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs.
Rudar M, Naberhuis JK, Suryawan A, Nguyen HV, Stoll B, Style CC, Verla MA, Olutoye OO, Burrin DG, Fiorotto ML, Davis TA
American journal of physiology. Endocrinology and metabolism 2021 Mar 1;320(3):E551-E565
American journal of physiology. Endocrinology and metabolism 2021 Mar 1;320(3):E551-E565
Effect of atorvastatin on Aβ(1-42) -induced alteration of SESN2, SIRT1, LC3II and TPP1 protein expressions in neuronal cell cultures.
Çelik H, Karahan H, Kelicen-Uğur P
The Journal of pharmacy and pharmacology 2020 Mar;72(3):424-436
The Journal of pharmacy and pharmacology 2020 Mar;72(3):424-436
Sestrin2 alleviates palmitate-induced endoplasmic reticulum stress, apoptosis, and defective invasion of human trophoblast cells.
Lee S, Shin J, Hong Y, Shin SM, Shin HW, Shin J, Lee SK, Park HW
American journal of reproductive immunology (New York, N.Y. : 1989) 2020 Apr;83(4):e13222
American journal of reproductive immunology (New York, N.Y. : 1989) 2020 Apr;83(4):e13222
Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism.
Shen T, Alvarez-Garcia O, Li Y, Olmer M, Lotz MK
Osteoarthritis and cartilage 2017 Feb;25(2):287-296
Osteoarthritis and cartilage 2017 Feb;25(2):287-296
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