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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [8]
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- Product number
- ABIN492725 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Sestrin 2 (SESN2) (N-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide corresponding to unique epitope on SESN2 from N-terminal (aa 1-75)region. Remarks: The peptide was post-synthetically covalently modified to achieve desiredantigenicity.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Vial size
- 0.1 mg
- Concentration
- 0.64-0.72 mg/ml (lot specific)
- Storage
- Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Submitted references Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.
Stimulation of autophagy by the p53 target gene Sestrin2.
Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins.
Role of histone acetylation in the activity-dependent regulation of sulfiredoxin and sestrin 2.
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.
The peroxiredoxin repair proteins.
p53-dependent stimulation of redox-related genes in the lymphoid organs of gamma-irradiated--mice identification of Haeme-oxygenase 1 as a direct p53 target gene.
Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.
Wempe F, De-Zolt S, Koli K, Bangsow T, Parajuli N, Dumitrascu R, Sterner-Kock A, Weissmann N, Keski-Oja J, von Melchner H
Disease models & mechanisms 2010 Mar-Apr;3(3-4):246-53
Disease models & mechanisms 2010 Mar-Apr;3(3-4):246-53
Stimulation of autophagy by the p53 target gene Sestrin2.
Maiuri MC, Malik SA, Morselli E, Kepp O, Criollo A, Mouchel PL, Carnuccio R, Kroemer G
Cell cycle (Georgetown, Tex.) 2009 May 15;8(10):1571-6
Cell cycle (Georgetown, Tex.) 2009 May 15;8(10):1571-6
Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins.
Woo HA, Bae SH, Park S, Rhee SG
Antioxidants & redox signaling 2009 Apr;11(4):739-45
Antioxidants & redox signaling 2009 Apr;11(4):739-45
Role of histone acetylation in the activity-dependent regulation of sulfiredoxin and sestrin 2.
Soriano FX, Papadia S, Bell KF, Hardingham GE
Epigenetics : official journal of the DNA Methylation Society 2009 Apr 1;4(3):152-8
Epigenetics : official journal of the DNA Methylation Society 2009 Apr 1;4(3):152-8
p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.
Budanov AV, Karin M
Cell 2008 Aug 8;134(3):451-60
Cell 2008 Aug 8;134(3):451-60
The peroxiredoxin repair proteins.
Jönsson TJ, Lowther WT
Sub-cellular biochemistry 2007;44:115-41
Sub-cellular biochemistry 2007;44:115-41
p53-dependent stimulation of redox-related genes in the lymphoid organs of gamma-irradiated--mice identification of Haeme-oxygenase 1 as a direct p53 target gene.
Meiller A, Alvarez S, Drané P, Lallemand C, Blanchard B, Tovey M, May E
Nucleic acids research 2007;35(20):6924-34
Nucleic acids research 2007;35(20):6924-34
Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.
Budanov AV, Sablina AA, Feinstein E, Koonin EV, Chumakov PM
Science (New York, N.Y.) 2004 Apr 23;304(5670):596-600
Science (New York, N.Y.) 2004 Apr 23;304(5670):596-600
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