LRRC2

This gene encodes a member of the leucine-rich repeat-containing family of proteins, which function in diverse biological pathways. This family member may possibly be a nuclear protein. Similarity to the RAS suppressor protein, as well as expression down-regulation observed in tumor cells, suggests that it may function as a tumor suppressor. The gene is located in the chromosome 3 common eliminated region 1 (C3CER1), a 1.4 Mb region that is commonly deleted in diverse tumors. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Sep 2011]

Description

Leucine rich repeat containing 2

Tissue specificity

Group enriched (heart muscle, skeletal muscle, tongue)

Subcell location

Nucleoplasm, Nuclear bodies, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

3 (46515385 - 46580099)

Ensembl ID

ENSG00000163827  (ver. 103.38)

Orthologs

Mouse Lrrc2: ENSMUSG00000032495

UniProt

Q9BYS8

neXtProt

NX_Q9BYS8

Human splice variants
Mouse splice variants

Protein structure