APR00515G

antibody from Leading Biology

Targeting: KCNMA1 KCa1.1, mSLO1, SLO

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Antibody Data

Product number

APR00515G

Provider

Leading Biology

Product name

KCa1.1 (1184-1200) Antibody

Antibody type

Polyclonal

Description

KCa1.1 (BKCa, Maxi K+ or slo) is part of a structurally diverse group of K+ channels that are activated by an increase in intracellular Ca2+. KCa1.1 shows a large single channel conductance when recordedelectrophysiologically and hence its name. It differs from the rest of the subfamily members in that it can be activated by both an increase in intracellular Ca2+ and by membrane depolarization. KCa1.1 is expressed in virtually all cell types where it causes hyperpolarization and helps to connectbetween intracellular Ca2+ signaling pathways and membrane excitability. Indeed, KCa1.1 channels have a crucial role in smooth muscle contractility, neuronal spike shaping andneurotransmitter release.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.