Antibody data
- Antibody Data
- Antigen structure
- References [16]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 11416-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11416-1-AP, RRID:AB_2245402
- Product name
- COX7A2L antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated COX7A2L antibody (Cat. #11416-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Optic atrophy 1 mediates muscle differentiation by promoting a metabolic switch via the supercomplex assembly factor SCAF1.
COX7A2L genetic variants determine cardiorespiratory fitness in mice and human.
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch.
SILAC-based complexome profiling dissects the structural organization of the human respiratory supercomplexes in SCAFI(KO) cells.
Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer.
Distinct Roles of Mitochondrial HIGD1A and HIGD2A in Respiratory Complex and Supercomplex Biogenesis.
Multiple pathways coordinate assembly of human mitochondrial complex IV and stabilization of respiratory supercomplexes.
Human COX7A2L Regulates Complex III Biogenesis and Promotes Supercomplex Organization Remodeling without Affecting Mitochondrial Bioenergetics.
Cardioprotective strategies preserve the stability of respiratory chain supercomplexes and reduce oxidative stress in reperfused ischemic hearts.
Deficiency of COX7RP, a mitochondrial supercomplex assembly promoting factor, lowers blood glucose level in mice.
COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation.
COX7AR is a Stress-inducible Mitochondrial COX Subunit that Promotes Breast Cancer Malignancy.
Supercomplex assembly determines electron flux in the mitochondrial electron transport chain.
Clinical response to chemotherapy in oesophageal adenocarcinoma patients is linked to defects in mitochondria.
MALDI imaging mass spectrometry reveals COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinoma.
Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain.
Triolo M, Baker N, Agarwal S, Larionov N, Podinić T, Khacho M
iScience 2024 Mar 15;27(3):109164
iScience 2024 Mar 15;27(3):109164
COX7A2L genetic variants determine cardiorespiratory fitness in mice and human.
Benegiamo G, Bou Sleiman M, Wohlwend M, Rodríguez-López S, Goeminne LJE, Laurila PP, Klevjer M, Salonen MK, Lahti J, Jha P, Cogliati S, Enriquez JA, Brumpton BM, Bye A, Eriksson JG, Auwerx J
Nature metabolism 2022 Oct;4(10):1336-1351
Nature metabolism 2022 Oct;4(10):1336-1351
Two independent respiratory chains adapt OXPHOS performance to glycolytic switch.
Fernández-Vizarra E, López-Calcerrada S, Sierra-Magro A, Pérez-Pérez R, Formosa LE, Hock DH, Illescas M, Peñas A, Brischigliaro M, Ding S, Fearnley IM, Tzoulis C, Pitceathly RDS, Arenas J, Martín MA, Stroud DA, Zeviani M, Ryan MT, Ugalde C
Cell metabolism 2022 Nov 1;34(11):1792-1808.e6
Cell metabolism 2022 Nov 1;34(11):1792-1808.e6
SILAC-based complexome profiling dissects the structural organization of the human respiratory supercomplexes in SCAFI(KO) cells.
Fernández-Vizarra E, López-Calcerrada S, Formosa LE, Pérez-Pérez R, Ding S, Fearnley IM, Arenas J, Martín MA, Zeviani M, Ryan MT, Ugalde C
Biochimica et biophysica acta. Bioenergetics 2021 Jul 1;1862(7):148414
Biochimica et biophysica acta. Bioenergetics 2021 Jul 1;1862(7):148414
Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer.
Hollinshead KER, Parker SJ, Eapen VV, Encarnacion-Rosado J, Sohn A, Oncu T, Cammer M, Mancias JD, Kimmelman AC
Cell reports 2020 Oct 6;33(1):108231
Cell reports 2020 Oct 6;33(1):108231
Distinct Roles of Mitochondrial HIGD1A and HIGD2A in Respiratory Complex and Supercomplex Biogenesis.
Timón-Gómez A, Garlich J, Stuart RA, Ugalde C, Barrientos A
Cell reports 2020 May 5;31(5):107607
Cell reports 2020 May 5;31(5):107607
Multiple pathways coordinate assembly of human mitochondrial complex IV and stabilization of respiratory supercomplexes.
Lobo-Jarne T, Pérez-Pérez R, Fontanesi F, Timón-Gómez A, Wittig I, Peñas A, Serrano-Lorenzo P, García-Consuegra I, Arenas J, Martín MA, Barrientos A, Ugalde C
The EMBO journal 2020 Jul 15;39(14):e103912
The EMBO journal 2020 Jul 15;39(14):e103912
Human COX7A2L Regulates Complex III Biogenesis and Promotes Supercomplex Organization Remodeling without Affecting Mitochondrial Bioenergetics.
Lobo-Jarne T, Nývltová E, Pérez-Pérez R, Timón-Gómez A, Molinié T, Choi A, Mourier A, Fontanesi F, Ugalde C, Barrientos A
Cell reports 2018 Nov 13;25(7):1786-1799.e4
Cell reports 2018 Nov 13;25(7):1786-1799.e4
Cardioprotective strategies preserve the stability of respiratory chain supercomplexes and reduce oxidative stress in reperfused ischemic hearts.
Ramírez-Camacho I, Correa F, El Hafidi M, Silva-Palacios A, Ostolga-Chavarría M, Esparza-Perusquía M, Olvera-Sánchez S, Flores-Herrera O, Zazueta C
Free radical biology & medicine 2018 Dec;129:407-417
Free radical biology & medicine 2018 Dec;129:407-417
Deficiency of COX7RP, a mitochondrial supercomplex assembly promoting factor, lowers blood glucose level in mice.
Shiba S, Ikeda K, Horie-Inoue K, Nakayama A, Tanaka T, Inoue S
Scientific reports 2017 Aug 8;7(1):7606
Scientific reports 2017 Aug 8;7(1):7606
COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation.
Pérez-Pérez R, Lobo-Jarne T, Milenkovic D, Mourier A, Bratic A, García-Bartolomé A, Fernández-Vizarra E, Cadenas S, Delmiro A, García-Consuegra I, Arenas J, Martín MA, Larsson NG, Ugalde C
Cell reports 2016 Aug 30;16(9):2387-98
Cell reports 2016 Aug 30;16(9):2387-98
COX7AR is a Stress-inducible Mitochondrial COX Subunit that Promotes Breast Cancer Malignancy.
Zhang K, Wang G, Zhang X, Hüttemann PP, Qiu Y, Liu J, Mitchell A, Lee I, Zhang C, Lee JS, Pecina P, Wu G, Yang ZQ, Hüttemann M, Grossman LI
Scientific reports 2016 Aug 23;6:31742
Scientific reports 2016 Aug 23;6:31742
Supercomplex assembly determines electron flux in the mitochondrial electron transport chain.
Lapuente-Brun E, Moreno-Loshuertos R, Acín-Pérez R, Latorre-Pellicer A, Colás C, Balsa E, Perales-Clemente E, Quirós PM, Calvo E, Rodríguez-Hernández MA, Navas P, Cruz R, Carracedo Á, López-Otín C, Pérez-Martos A, Fernández-Silva P, Fernández-Vizarra E, Enríquez JA
Science (New York, N.Y.) 2013 Jun 28;340(6140):1567-70
Science (New York, N.Y.) 2013 Jun 28;340(6140):1567-70
Clinical response to chemotherapy in oesophageal adenocarcinoma patients is linked to defects in mitochondria.
Aichler M, Elsner M, Ludyga N, Feuchtinger A, Zangen V, Maier SK, Balluff B, Schöne C, Hierber L, Braselmann H, Meding S, Rauser S, Zischka H, Aubele M, Schmitt M, Feith M, Hauck SM, Ueffing M, Langer R, Kuster B, Zitzelsberger H, Höfler H, Walch AK
The Journal of pathology 2013 Aug;230(4):410-9
The Journal of pathology 2013 Aug;230(4):410-9
MALDI imaging mass spectrometry reveals COX7A2, TAGLN2 and S100-A10 as novel prognostic markers in Barrett's adenocarcinoma.
Elsner M, Rauser S, Maier S, Schöne C, Balluff B, Meding S, Jung G, Nipp M, Sarioglu H, Maccarrone G, Aichler M, Feuchtinger A, Langer R, Jütting U, Feith M, Küster B, Ueffing M, Zitzelsberger H, Höfler H, Walch A
Journal of proteomics 2012 Aug 3;75(15):4693-704
Journal of proteomics 2012 Aug 3;75(15):4693-704
Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain.
Li N, Bates DJ, An J, Terry DA, Wang E
Neurobiology of aging 2011 May;32(5):944-55
Neurobiology of aging 2011 May;32(5):944-55
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 11416-1-AP( COX7A2L Antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The COX7A2L antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human COX7A2L. This antibody recognizes human,mouse,rat antigen. The COX7A2L antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human ovary tumor using 11416-1-AP(COX7A2L antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue