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- References [21]
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- Immunohistochemistry [1]
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- Product number
- 16091-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16091-1-AP, RRID:AB_2096979
- Product name
- EEF1A2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated EEF1A2 antibody (Cat. #16091-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Face-valid phenotypes in a mouse model of the most common mutation in EEF1A2-related neurodevelopmental disorder.
Loss of NSUN6 inhibits osteosarcoma progression by downregulating EEF1A2 expression and activation of Akt/mTOR signaling pathway via m(5)C methylation.
Endogenous epitope tagging of eEF1A2 in mice reveals early embryonic expression of eEF1A2 and subcellular compartmentalisation of neuronal eEF1A1 and eEF1A2.
Autism- and epilepsy-associated EEF1A2 mutations lead to translational dysfunction and altered actin bundling.
Autism- and epilepsy-associated EEF1A2 mutations lead to translational dysfunction and altered actin bundling.
Anisomycin inhibits Coxsackievirus B replication by promoting the lysosomal degradation of eEF1A1.
EEF1A2 accelerates the protein translation of chemokine in rat myocardial cells induced by ischemia-reperfusion.
Immune Microenvironment and Lineage Tracing Help to Decipher Rosette-Forming Glioneuronal Tumors: A Multi-Omics Analysis.
KLF4-PFKFB3-driven glycolysis is essential for phenotypic switching of vascular smooth muscle cells.
Nannocystin ax, an eEF1A inhibitor, induces G1 cell cycle arrest and caspase-independent apoptosis through cyclin D1 downregulation in colon cancer in vivo.
Comparison of the sensitivity of Western blotting between PVDF and NC membranes.
Recapitulation of the EEF1A2 D252H neurodevelopmental disorder-causing missense mutation in mice reveals a toxic gain of function.
EEF1A1 deacetylation enables transcriptional activation of remyelination.
Translation elongation factor 1A2 is encoded by one of four closely related eef1a genes and is dispensable for survival in zebrafish.
SNX16 activates c-Myc signaling by inhibiting ubiquitin-mediated proteasomal degradation of eEF1A2 in colorectal cancer development.
Peptidome characterization of ovarian cancer serum and the identification of tumor suppressive peptide ZYX(36-58).
A rapid and specific method to simultaneously quantify eukaryotic elongation factor 1A1 and A2 protein levels in cancer cells.
A comparative proteomic analysis reveals important proteins for the fertilization and early embryonic development of the oyster Crassostrea gigas.
Biallelic mutations in the gene encoding eEF1A2 cause seizures and sudden death in F0 mice.
Molecular markers associated with nonepithelial ovarian cancer in formalin-fixed, paraffin-embedded specimens by genome wide expression profiling.
Dissecting the expression of EEF1A1/2 genes in human prostate cancer cells: the potential of EEF1A2 as a hallmark for prostate transformation and progression.
Marshall GF, Fasol M, Davies FCJ, Le Seelleur M, Fernandez Alvarez A, Bennett-Ness C, Gonzalez-Sulser A, Abbott CM
Disease models & mechanisms 2024 Jun 1;17(6)
Disease models & mechanisms 2024 Jun 1;17(6)
Loss of NSUN6 inhibits osteosarcoma progression by downregulating EEF1A2 expression and activation of Akt/mTOR signaling pathway via m(5)C methylation.
Hu S, Yang M, Xiao K, Yang Z, Cai L, Xie Y, Wang L, Wei R
Experimental and therapeutic medicine 2023 Sep;26(3):457
Experimental and therapeutic medicine 2023 Sep;26(3):457
Endogenous epitope tagging of eEF1A2 in mice reveals early embryonic expression of eEF1A2 and subcellular compartmentalisation of neuronal eEF1A1 and eEF1A2.
Davies FCJ, Marshall GF, Pegram E, Gadd D, Abbott CM
Molecular and cellular neurosciences 2023 Sep;126:103879
Molecular and cellular neurosciences 2023 Sep;126:103879
Autism- and epilepsy-associated EEF1A2 mutations lead to translational dysfunction and altered actin bundling.
Mohamed MS, Klann E
Proceedings of the National Academy of Sciences of the United States of America 2023 Sep 19;120(38):e2307704120
Proceedings of the National Academy of Sciences of the United States of America 2023 Sep 19;120(38):e2307704120
Autism- and epilepsy-associated EEF1A2 mutations lead to translational dysfunction and altered actin bundling.
Mohamed MS, Klann E
bioRxiv : the preprint server for biology 2023 Jun 7;
bioRxiv : the preprint server for biology 2023 Jun 7;
Anisomycin inhibits Coxsackievirus B replication by promoting the lysosomal degradation of eEF1A1.
Shao E, Zhao S, Dong Y, Wang Y, Fei Y, Li S, Wang L, Bashir T, Luan T, Lin L, Wang Y, Zhao W, Zhong Z
Antiviral research 2023 Jul;215:105621
Antiviral research 2023 Jul;215:105621
EEF1A2 accelerates the protein translation of chemokine in rat myocardial cells induced by ischemia-reperfusion.
Zhang ZJ, Sun ZX, Liu HJ
Heliyon 2023 Apr;9(4):e15305
Heliyon 2023 Apr;9(4):e15305
Immune Microenvironment and Lineage Tracing Help to Decipher Rosette-Forming Glioneuronal Tumors: A Multi-Omics Analysis.
Lerond J, Morisse MC, Letourneur Q, Gimonnet C, Navarro S, Gaspar C, Idbaih A, Bielle F
Journal of neuropathology and experimental neurology 2022 Oct 18;81(11):873-884
Journal of neuropathology and experimental neurology 2022 Oct 18;81(11):873-884
KLF4-PFKFB3-driven glycolysis is essential for phenotypic switching of vascular smooth muscle cells.
Zhang X, Zheng B, Zhao L, Shen J, Yang Z, Zhang Y, Fan R, Zhang M, Ma D, Zheng L, Zhao M, Liu H, Wen J
Communications biology 2022 Dec 5;5(1):1332
Communications biology 2022 Dec 5;5(1):1332
Nannocystin ax, an eEF1A inhibitor, induces G1 cell cycle arrest and caspase-independent apoptosis through cyclin D1 downregulation in colon cancer in vivo.
Hou Y, Liu R, Xia M, Sun C, Zhong B, Yu J, Ai N, Lu JJ, Ge W, Liu B, Chen X
Pharmacological research 2021 Nov;173:105870
Pharmacological research 2021 Nov;173:105870
Comparison of the sensitivity of Western blotting between PVDF and NC membranes.
Xiang Y, Zheng Y, Liu S, Liu G, Li Z, Dong W
Scientific reports 2021 Jun 8;11(1):12022
Scientific reports 2021 Jun 8;11(1):12022
Recapitulation of the EEF1A2 D252H neurodevelopmental disorder-causing missense mutation in mice reveals a toxic gain of function.
Davies FCJ, Hope JE, McLachlan F, Marshall GF, Kaminioti-Dumont L, Qarkaxhija V, Nunez F, Dando O, Smith C, Wood E, MacDonald J, Hardt O, Abbott CM
Human molecular genetics 2020 Jun 27;29(10):1592-1606
Human molecular genetics 2020 Jun 27;29(10):1592-1606
EEF1A1 deacetylation enables transcriptional activation of remyelination.
Duman M, Vaquié A, Nocera G, Heller M, Stumpe M, Siva Sankar D, Dengjel J, Meijer D, Yamaguchi T, Matthias P, Zeis T, Schaeren-Wiemers N, Hayoz A, Ruff S, Jacob C
Nature communications 2020 Jul 9;11(1):3420
Nature communications 2020 Jul 9;11(1):3420
Translation elongation factor 1A2 is encoded by one of four closely related eef1a genes and is dispensable for survival in zebrafish.
Idigo NJ, Soares DC, Abbott CM
Bioscience reports 2020 Jan 31;40(1)
Bioscience reports 2020 Jan 31;40(1)
SNX16 activates c-Myc signaling by inhibiting ubiquitin-mediated proteasomal degradation of eEF1A2 in colorectal cancer development.
Shen Z, Li Y, Fang Y, Lin M, Feng X, Li Z, Zhan Y, Liu Y, Mou T, Lan X, Wang Y, Li G, Wang J, Deng H
Molecular oncology 2020 Feb;14(2):387-406
Molecular oncology 2020 Feb;14(2):387-406
Peptidome characterization of ovarian cancer serum and the identification of tumor suppressive peptide ZYX(36-58).
Wang X, Liu G, Sheng N, Zhang M, Pan X, Liu S, Huang K, Cong Y, Xu Q, Jia X, Xu J
Annals of translational medicine 2020 Aug;8(15):925
Annals of translational medicine 2020 Aug;8(15):925
A rapid and specific method to simultaneously quantify eukaryotic elongation factor 1A1 and A2 protein levels in cancer cells.
Bosutti A, Kalaja O, Zanconati F, Dapas B, Grassi G, Passamonti S, Scaggiante B
Journal of pharmaceutical and biomedical analysis 2019 Nov 30;176:112814
Journal of pharmaceutical and biomedical analysis 2019 Nov 30;176:112814
A comparative proteomic analysis reveals important proteins for the fertilization and early embryonic development of the oyster Crassostrea gigas.
Huang X, Huan P, Liu B
Proteomics 2017 Jan;17(1-2)
Proteomics 2017 Jan;17(1-2)
Biallelic mutations in the gene encoding eEF1A2 cause seizures and sudden death in F0 mice.
Davies FC, Hope JE, McLachlan F, Nunez F, Doig J, Bengani H, Smith C, Abbott CM
Scientific reports 2017 Apr 5;7:46019
Scientific reports 2017 Apr 5;7:46019
Molecular markers associated with nonepithelial ovarian cancer in formalin-fixed, paraffin-embedded specimens by genome wide expression profiling.
Vui-Kee K, Mohd Dali AZ, Mohamed Rose I, Ghazali R, Jamal R, Mokhtar NM
The Kaohsiung journal of medical sciences 2012 May;28(5):243-50
The Kaohsiung journal of medical sciences 2012 May;28(5):243-50
Dissecting the expression of EEF1A1/2 genes in human prostate cancer cells: the potential of EEF1A2 as a hallmark for prostate transformation and progression.
Scaggiante B, Dapas B, Bonin S, Grassi M, Zennaro C, Farra R, Cristiano L, Siracusano S, Zanconati F, Giansante C, Grassi G
British journal of cancer 2012 Jan 3;106(1):166-73
British journal of cancer 2012 Jan 3;106(1):166-73
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 16091-1-AP(EEF1A2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The EEF1A2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human EEF1A2. This antibody recognizes human,mouse,rat antigen. The EEF1A2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
