APR03408G

antibody from Leading Biology

Targeting: EEF1A2 EEF1AL, HS1, STN, STNL

Western blot (Recommended by provider)

Antibody Data

Product number

APR03408G

Provider

Leading Biology

Product name

Phospho-Ser358 Eukaryotic Elongation Factor 1 alpha 2 (eEF1A2) Antibody

Antibody type

Polyclonal

Description

Eukaryotic Elongation Factor eEF1A exists in two variant forms, eEF1A1 and eEF1A2. While eEF1A1 is almost ubiquitously expressed in humans, eEF1A2 is predominantly found in heart, brain, and skeletal muscle (Knudsen et al., 1993). Expression of eEF1A2 may have a role in ovarian cancer, as its expression is drastically increased in human ovarian tumors (Anand et al., 2002). Due to differences in structural models between the two isoforms, eEF1A1 and eEF1A2 likely have variant-specific phosphorylation sites (Soares et al., 2009). Ribosome-associated JNK phosphorylates Ser358 on eEF1A2 to promote degradation of newly synthesized polypeptides by the proteasome (Gandin et al., 2013).

Reactivity

Mouse

Host

Rabbit

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.