FGD2

The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocytes, macrophages, and dendritic cells. The encoded protein may play a role in leukocyte signaling and vesicle trafficking in antigen-presenting cells in the immune system. [provided by RefSeq, Oct 2016]

Description

FYVE, RhoGEF and PH domain containing 2

Tissue specificity

Tissue enhanced (lymphoid tissue)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (37005646 - 37029069)

Ensembl ID

ENSG00000146192  (ver. 103.38)

Orthologs

Mouse Fgd2: ENSMUSG00000024013

UniProt

Q7Z6J4

neXtProt

NX_Q7Z6J4

Human splice variants
Mouse splice variants

Protein structure