16133-1-AP

antibody from Proteintech Group

Targeting: MUL1 C1orf166, FLJ12875, GIDE, MAPL, MULAN, RNF218

Provider product page for 16133-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [14]
Comments [0]
Validations
Immunohistochemistry [2]

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Product number: 16133-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#16133-1-AP, RRID:AB_2147111
Product name: MUL1 antibody
Antibody type: Polyclonal
Description: KD/KO validated MUL1 antibody (Cat. #16133-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

MUL1 protein structure - 16133-1-AP shown in red.

Submitted references Deficiency in the conserved ECHS1 gene causes Leigh syndrome by impairing mitochondrial respiration efficiency and suppressing ADRB2-PKA signaling.

Wang B, Qin Y, Bao Y, Chen S, Zheng J, Lin S, Zheng K, Duan S
Biochimica et biophysica acta. Molecular basis of disease 2025 Oct;1871(7):167930

SLC44A2 negatively regulates mitochondrial fatty acid oxidation to suppress colorectal progression by blocking the MUL1-CPT2 interaction.

Yang Y, Zheng L, He J, Wu T, Yang H, Zhang B, Zhou S, Lu Y, He X, Li J, Wang N
Cell death & disease 2025 Jul 1;16(1):468

The mitochondrial E3 ligase MAPL SUMOylates Drp1 to facilitate mitochondrial fission in intervertebral disc degeneration.

Lin Z, Lu X, Xu G, Song J, Wang H, Xia X, Lu F, Jiang J, Zhu W, Yu Z, Ma X, Zou F
Bone research 2025 Aug 12;13(1):72

SUMO E3 ligase MUL1 inhibits lymph node metastasis of bladder cancer by mediating mitochondrial HSPA9 translocation.

Wu J, Huang M, Dong W, Chen Y, Zhou Q, Zhang Q, Zheng J, Liu Y, Zhang Y, Liu S, Yang C, Chen S, Huang J, Lin T, Chen X
International journal of biological sciences 2024;20(10):3986-4006

Inactivation of mitochondrial MUL1 E3 ubiquitin ligase deregulates mitophagy and prevents diet-induced obesity in mice.

Cilenti L, Di Gregorio J, Mahar R, Liu F, Ambivero CT, Periasamy M, Merritt ME, Zervos AS
Frontiers in molecular biosciences 2024;11:1397565

PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer.

Xu L, Xiang W, Yang J, Gao J, Wang X, Meng L, Ye K, Zhao XH, Zhang XD, Jin L, Ye Y
Journal of experimental & clinical cancer research : CR 2024 Jan 11;43(1):17

MUL1 identified as mitochondria-linked biomarker promoting cisplatin resistance in OC cells.

Liu L, Zou C, Shen J, Huang R, Zhang F, Du Y, Luo X, Yang A, Zhang J, Guan Y, Yan X
Gene 2024 Dec 20;930:148841

Ginsenoside compound K protects against cerebral ischemia/reperfusion injury via Mul1/Mfn2-mediated mitochondrial dynamics and bioenergy.

Huang Q, Li J, Chen J, Zhang Z, Xu P, Qi H, Chen Z, Liu J, Lu J, Shi M, Zhang Y, Ma Y, Zhao D, Li X
Journal of ginseng research 2023 May;47(3):408-419

CRTAC1 enhances the chemosensitivity of non-small cell lung cancer to cisplatin by eliciting RyR-mediated calcium release and inhibiting Akt1 expression.

Jin Z, Zhao L, Chang Y, Jin R, Hu F, Wu S, Xue Z, Ma Y, Chen C, Zheng M, Chang Y, Jin H, Xie Q, Huang C, Huang H
Cell death & disease 2023 Aug 26;14(8):563

Inhibition of Prostaglandin E2 Receptor EP3 Attenuates Oxidative Stress and Neuronal Apoptosis Partially by Modulating p38MAPK/FOXO3/Mul1/Mfn2 Pathway after Subarachnoid Hemorrhage in Rats.

Liu Y, Liu R, Huang L, Zuo G, Dai J, Gao L, Shi H, Fang Y, Lu Q, Okada T, Wang Z, Hu X, Lenahan C, Tang J, Xiao J, Zhang JH
Oxidative medicine and cellular longevity 2022;2022:7727616

Upregulation of mitochondrial E3 ubiquitin ligase 1 in rat heart contributes to ischemia/reperfusion injury.

Wang SJ, Chen H, Tang LJ, Tu H, Liu B, Li NS, Luo XJ, Peng J
Canadian journal of physiology and pharmacology 2020 May;98(5):259-266

Mitochondrial E3 ubiquitin ligase 1 promotes brain injury by disturbing mitochondrial dynamics in a rat model of ischemic stroke.

Ren KD, Liu WN, Tian J, Zhang YY, Peng JJ, Zhang D, Li NS, Yang J, Peng J, Luo XJ
European journal of pharmacology 2019 Oct 15;861:172617

Trichostatin A inhibits skeletal muscle atrophy induced by cigarette smoke exposure in mice.

Ding J, Li F, Cong Y, Miao J, Wu D, Liu B, Wang L
Life sciences 2019 Oct 15;235:116800

Natural compound methyl protodioscin protects rat brain from ischemia/reperfusion injury through regulation of Mul1/SOD2 pathway.

Guo S, Zhang YY, Peng JJ, Li YQ, Liu WN, Tang MX, Zhang XJ, Yang J, Peng J, Luo XJ
European journal of pharmacology 2019 Apr 15;849:50-58

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human kidney using 16133-1-AP(MUL1 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The MUL1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MUL1. This antibody recognizes human, mouse, rat antigen. The MUL1 antibody has been validated for the following applications: ELISA, IHC analysis.
Appendix: 16133-1-AP.pdf

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