ADAM11

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Description

ADAM metallopeptidase domain 11

Tissue specificity

Group enriched (brain, heart muscle)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

17 (44758988 - 44781846)

Ensembl ID

ENSG00000073670  (ver. 103.38)

Orthologs

Mouse Adam11: ENSMUSG00000020926

UniProt

O75078

neXtProt

NX_O75078

Human splice variants
Mouse splice variants

Protein structure