15140-1-AP

antibody from Proteintech Group

Targeting: GLO1 GLOD1

Provider product page for 15140-1-AP

Western blot

ELISA

Immunoprecipitation

Antibody data

Antibody Data
Antigen structure
References [17]
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Validations
Western blot [1]

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Product number: 15140-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#15140-1-AP, RRID:AB_2109890
Product name: GLO1 antibody
Antibody type: Polyclonal
Description: KD/KO validated GLO1 antibody (Cat. #15140-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

GLO1 protein structure - 15140-1-AP shown in red.

Submitted references Lithocarpus litseifolius and trilobatin ameliorate diabetic nephropathy through alleviating carbonyl stress by inhibiting AGEs/RAGE/NF-κB pathway.

Chen XM, Chen JX, Chen XM, Gao YX, Zeng CY, Chen DY, Xiang XQ, Hao XT, Wang SM, Tang D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 15;156:158204

Methylglyoxal induces oxidative stress and ferroptosis of renal tubular epithelial cells in acute and chronic kidney injury mice.

Zhang Y, Zhang X, Ren J, Sun H, Yang Z, Wang J
Frontiers in cell and developmental biology 2025;13:1604575

Integrating metabolomics and network pharmacology to investigate Da-Chai-Hu Decoction prevents kidney injury in diabetic mice.

Wang X, Zhong ZJ, Chen PF, Deng CF, Chen XM, Xin GZ, Tang D
Journal of ethnopharmacology 2025 Jan 31;340:119158

Huang-Lian-Jie-Du Decoction alleviates diabetic encephalopathy by regulating inflammation and pyroptosis via suppression of AGEs/RAGE/NF-κB pathways.

Zhuang GD, Deng SM, Chen MD, Deng CF, Gu WT, Wang SM, Tang D
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118787

Paracrine Orchestration of Tumor Microenvironment Remodeling Induced by GLO1 Potentiates Lymph Node Metastasis in Breast Cancer.

Xie J, Liu W, Deng X, Wang H, Ou X, An X, Situ MY, Yang A, Peng C, He R, Xie Y, Tang H, Chen Y, Liang JY, Shao R, Xiao W, Zheng S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(32):e00722

Butyrate increases methylglyoxal production through regulation of the JAK2/Stat3/Nrf2/Glo1 pathway in castration‑resistant prostate cancer cells.

Hsia YJ, Lin ZM, Zhang T, Chou TC
Oncology reports 2024 May;51(5)

Methylglyoxal accumulation contributes to accelerated brain aging in spontaneously hypertensive rats.

Zhang WY, Zhao CM, Wang CS, Xie X, Li YQ, Chen BB, Feng L, Jiang P
Free radical biology & medicine 2024 Jan;210:108-119

Dang-Gui-Bu-Xue decoction against diabetic nephropathy via modulating the carbonyl compounds metabolic profile and AGEs/RAGE pathway.

Zhang ZT, Qi Y, Chen P, Chen L, Jiang Y, Fan Z, Guan H, Bai L, Liu J, Zhao D, Yan G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156104

Protective effects of Huang-Qi-Ge-Gen decoction against diabetic liver injury through regulating PI3K/AKT/Nrf2 pathway and metabolic profiling.

Zhang ZT, Liang QF, Wang X, Wang RS, Duan TT, Wang SM, Tang D
Journal of ethnopharmacology 2024 Apr 6;323:117647

Protective effect of heat-processed Gynostemma pentaphyllum on high fat diet-induced glucose metabolic disorders mice.

Xie JB, Xie P, Guo M, Li FF, Xiao MY, Qi YS, Pei WJ, Luo HT, Gu YL, Piao XL
Frontiers in pharmacology 2023;14:1215150

Glyoxalase 1 inhibitor BBGC suppresses the progression of chronic lymphocytic leukemia and promotes the efficacy of Palbociclib.

Tang J, Zhong J, Yang Z, Su Q, Mo W
Biochemical and biophysical research communications 2023 Apr 2;650:96-102

Inulin-type fructans change the gut microbiota and prevent the development of diabetic nephropathy.

Luo L, Luo J, Cai Y, Fu M, Li W, Shi L, Liu J, Dong R, Xu X, Tu L, Yang Y
Pharmacological research 2022 Sep;183:106367

Nordihydroguaiaretic acid inhibits glyoxalase I, and causes the accumulation of methylglyoxal followed by cell-growth inhibition.

Watanabe M, Toyomura T, Ikegami R, Suwaki Y, Sada M, Wake H, Nishinaka T, Hatipoglu OF, Takahashi H, Nishibori M, Mori S
Molecular biology reports 2022 Nov;49(11):10499-10507

Protective effects of Huang-Lian-Jie-Du Decoction on diabetic nephropathy through regulating AGEs/RAGE/Akt/Nrf2 pathway and metabolic profiling in db/db mice.

Tang D, He WJ, Zhang ZT, Shi JJ, Wang X, Gu WT, Chen ZQ, Xu YH, Chen YB, Wang SM
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153777

Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications.

Tian S, Feng J, Cao Y, Shen S, Cai Y, Yang D, Yan R, Wang L, Zhang H, Zhong X, Gao P
Life science alliance 2019 Oct;2(5)

C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis.

Allen SP, Hall B, Woof R, Francis L, Gatto N, Shaw AC, Myszczynska M, Hemingway J, Coldicott I, Willcock A, Job L, Hughes RM, Boschian C, Bayatti N, Heath PR, Bandmann O, Mortiboys H, Ferraiuolo L, Shaw PJ
Brain : a journal of neurology 2019 Dec 1;142(12):3771-3790

Glyoxalase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cells.

Tamori S, Nozaki Y, Motomura H, Nakane H, Katayama R, Onaga C, Kikuchi E, Shimada N, Suzuki Y, Noike M, Hara Y, Sato K, Sato T, Yamamoto K, Hanawa T, Imai M, Abe R, Yoshimori A, Takasawa R, Tanuma SI, Akimoto K
Oncotarget 2018 Nov 23;9(92):36515-36529

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The GLO1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GLO1. This antibody recognizes human, mouse, rat antigen. The GLO1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 15140-1-AP.pdf

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