12197-1-AP

antibody from Proteintech Group

Targeting: WWP2 AIP2

Provider product page for 12197-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [35]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 12197-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12197-1-AP, RRID:AB_10597536
Product name: WWP2 antibody
Antibody type: Polyclonal
Description: WWP2 antibody (Cat. #12197-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

WWP2 protein structure - 12197-1-AP shown in red.

Submitted references Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia.

Le BV, Vekariya U, Toma MM, Nieborowska-Skorska M, Caron MC, Gozdecka M, Haydar Z, Walsh M, Ghosh J, Vaughan-Williams E, Podszywalow-Bartnicka P, Kukuyan AM, Ziolkowska S, Atkins J, Hadzijusufovic E, Chandramouly G, Nejati R, Piwocka K, Pomerantz R, Vassiliou GS, Huntly BJP, Valent P, Wasik M, Bellacosa A, Masson JY, Gupta GP, Challen GA, Skorski T
Cell reports. Medicine 2026 Mar 17;7(3):102687

Inhibition of Setd7 protects against cardiomyocyte hypertrophy via inhibiting lipid oxidation.

Su HB, Wang JH, Zhang YY, Xu J, Liu JY, Li YH, Xiao CX, Wang CY, Chang J, Liu XH
Acta pharmacologica Sinica 2026 Feb;47(2):344-356

Neural stem cell-derived exosomal PA2G4 induces ANXA2 degradation to promote mitophagy and alleviate neuronal oxidative stress in cerebral ischemia/reperfusion.

Dai M, Lu T, Li J, Yu H
Apoptosis : an international journal on programmed cell death 2026 Feb 20;31(3)

Dietary fiber-derived butyrate ameliorates pulmonary fibrosis by inhibiting YBX1 ubiquitination.

Li M, Pan T, Ma X, Hu X, Jiang J, Zhang Y, Zhang L, Pan X, Wang Y
The Journal of nutritional biochemistry 2026 Apr;150:110210

K63-linked ubiquitylation of S2P-RNAPII regulates transcription in a DNAPK inter-dependent manner in response to double-strand breaks.

Pantazi V, Smith P, Pahi ZG, Katona M, Pap A, Darula Z, Fischer R, Vendrell I, Kessler BM, van Vugt MATM, D'Angiolella V, Pankotai T
Nucleic acids research 2026 Apr 23;54(8)

Evolutionary conserved regulation of TFEB stability by the E3 ubiquitin ligase WWP2 modulates response to stress in vivo.

Garcia-Sanchez JA, Bonnet E, Loubatier C, Doye A, Paillier G, Segui F, Larbret F, Chaintreuil P, Batistic L, Torre C, Deckert M, Polanowska J, Munro P, Boyer L, Visvikis O
iScience 2025 Feb 21;28(2):111838

WWP2 Overexpression Represses NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Injury Through the Degradation of MAVS.

Yu H, Li J, Lu T, Dai M, Wan X
Glia 2025 Dec;73(12):2445-2463

Endothelial cells-derived SEMA3G suppresses glioblastoma stem cells by inducing c-Myc degradation.

Min PX, Feng LL, Zhang YX, Jiang CC, Zhang HZ, Chen Y, Fukunaga K, Liu F, Zhang YJ, Sasaki T, Qian X, Horimoto K, Jiang JD, Lu YM, Han F
Cell death and differentiation 2025 Dec;32(12):2340-2354

FAM189A2 activates Hippo signaling pathway by abrogating WWP2-mediated LATS1 ubiquitination, to inhibit the glycolysis and proliferation processes of lung adenocarcinoma.

Chen B, Rong X, Feng Y, Hou Y, Fu L, Han Q, Song Y, Lin X
Journal of translational medicine 2025 Dec 5;24(1):48

WWP2-induced inhibition of hepatocellular carcinoma cellular senescence via the ubiquitination and degradation of p21.

Chen X, Wang J, Yan Z, Du X, Zhang Z, Liu X, Hu L, He K, Zhang J, Han Y
Cell death & disease 2025 Dec 12;17(1):96

The BAG3-HSP70-CHIP axis controls the degradation of TGFBR2 in cardiac fibroblasts.

Morsink MAJ, Watkins JM, Zhu K, Zhang X, Luo LJ, Fine BM, Wang BZ, Vunjak-Novakovic G
Journal of molecular and cellular cardiology 2025 Aug;205:13-23

LAPTM5 confers cisplatin resistance in NSCLC by suppressing LAMP1 ubiquitination to stabilize lysosomal membranes and sustain autophagic flux.

Wu F, Li C, Song X, Xie L
Cellular signalling 2025 Aug;132:111834

UPF1 Alleviates Myocardial Ischemia-Reperfusion Injury by Regulating SMURF2-Mediated Ubiquitination Degradation of FOXA2.

Li A, Li P, Mu C, Li D, Chen K, Liang Z
Korean circulation journal 2025 Apr;55(4):305-321

µMap proximity labeling in living cells reveals stress granule disassembly mechanisms.

Pan CR, Knutson SD, Huth SW, MacMillan DWC
Nature chemical biology 2025 Apr;21(4):490-500

CYYR1 promotes the degradation of the E3 ubiquitin ligase WWP1 and is associated with favorable prognosis in breast cancer.

Perron T, Boissan M, Bièche I, Courtois L, Dingli F, Loew D, Chouchène M, Colasse S, Levy L, Prunier C
The Journal of biological chemistry 2024 Sep;300(9):107601

DNA polymerase theta-mediated DNA repair is a functional dependency and therapeutic vulnerability in DNMT3A deficient leukemia cells.

Le BV, Vekariya U, Toma MM, Nieborowska-Skorska M, Caron MC, Gozdecka M, Haydar Z, Walsh M, Ghosh J, Vaughan-Williams E, Podszywalow-Bartnicka P, Kukuyan AM, Ziolkowska S, Hadzijusufovic E, Chandramouly G, Piwocka K, Pomerantz R, Vassiliou GS, Huntly BJ, Valent P, Bellacosa A, Masson JY, Gupta GP, Challen GA, Skorski T
bioRxiv : the preprint server for biology 2024 Sep 19;

Ubiquitination of NS1 Confers Differential Adaptation of Zika Virus in Mammalian Hosts and Mosquito Vectors.

Huang C, Jiang T, Pan W, Feng T, Zhou X, Wu Q, Ma F, Dai J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(39):e2408024

RACK1 enhances STAT3 stability and promotes T follicular helper cell development and function during blood-stage Plasmodium infection in mice.

Cheng Q, Yang X, Zou T, Sun L, Zhang X, Deng L, Wu M, Gai W, Jiang H, Guo T, Lu Y, Dong J, Niu C, Pan W, Zhang J
PLoS pathogens 2024 Jul;20(7):e1012352

USP25 Elevates SHLD2-Mediated DNA Double-Strand Break Repair and Regulates Chemoresponse in Cancer.

Li Y, Li L, Wang X, Zhao F, Yang Y, Zhou Y, Zhang J, Wang L, Jiang Z, Zhang Y, Chen Y, Wu C, Li K, Zhang T, Wang P, Mao Z, Zhu W, Xu X, Liang S, Lou Z, Yuan J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(28):e2403485

Histone demethylase PHF8 protected against chondrocyte injury and alleviated posttraumatic osteoarthritis by epigenetically enhancing WWP2 expression.

Tang X, He J, Hao Y
Human & experimental toxicology 2024 Jan-Dec;43:9603271241292165

WWP2 protects against sepsis-induced cardiac injury through inhibiting cardiomyocyte ferroptosis.

Li Z, Wu B, Chen J, Ye N, Ma R, Song C, Sun Y, Zhang X, Sun G
Journal of translational internal medicine 2024 Feb;12(1):35-50

Atorvastatin rescues vascular endothelial injury in hypertension by WWP2-mediated ubiquitination and degradation of ATP5A.

Yin Z, You S, Zhang S, Zhang L, Wu B, Huang X, Lu S, Cao L, Zhang Y, Li D, Zhang X, Liu J, Sun Y, Zhang N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115228

Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X.

You S, Xu J, Yin Z, Wu B, Wang P, Hao M, Cheng C, Liu M, Zhao Y, Jia P, Jiang H, Li D, Cao L, Zhang X, Zhang Y, Sun Y, Zhang N
Cardiovascular diabetology 2023 May 6;22(1):107

High dose isoleucine stabilizes nuclear PTEN to suppress the proliferation of lung cancer.

Wang H, Chen S, Kang W, Ding B, Cui S, Zhou L, Zhang N, Luo H, Wang M, Zhang F, Zhao Z, Guo Z, Wang C, Li L, Wang Z, Chen X, Wang Y
Discover oncology 2023 Feb 23;14(1):25

WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein.

Zou J, Zhou L, Le Y, Fang Z, Zhong M, Nie F, Wei X, Zhang X, Chen Z, Cai L, Wang H, Xiong J, Fang Z, Xiang X
Cell communication and signaling : CCS 2023 Feb 17;21(1):38

14-3-3σ-NEDD4L axis promotes ubiquitination and degradation of HIF-1α in colorectal cancer.

Liu S, Guo R, Xu H, Yang J, Luo H, Yeung SJ, Li K, Lee MH, Yang R
Cell reports 2023 Aug 29;42(8):112870

miR-328-5p Induces Human Intervertebral Disc Degeneration by Targeting WWP2.

Yan J, Wu LG, Zhang M, Fang T, Pan W, Zhao JL, Zhou Q
Oxidative medicine and cellular longevity 2022;2022:3511967

The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia.

Lu X, Huang X, Xu H, Lu S, You S, Xu J, Zhan Q, Dong C, Zhang N, Zhang Y, Cao L, Zhang X, Zhang N, Zhang L
Cell death discovery 2022 Oct 18;8(1):421

A WWP2-PTEN-KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice.

Fu J, Zhang X, Zheng H, Yang G, Chen Z, Yuan G
The Journal of biological chemistry 2022 Aug;298(8):102220

WWP2 Promotes Odontoblastic Differentiation by Monoubiquitinating KLF5.

Fu J, Zheng H, Xue Y, Jin R, Yang G, Chen Z, Yuan G
Journal of dental research 2021 Apr;100(4):432-439

Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling.

Zhang N, Zhang Y, Qian H, Wu S, Cao L, Sun Y
Cell death and differentiation 2020 Sep;27(9):2605-2619

Costunolide represses hepatic fibrosis through WW domain-containing protein 2-mediated Notch3 degradation.

Ge MX, Liu HT, Zhang N, Niu WX, Lu ZN, Bao YY, Huang R, Yu DK, Shao RG, He HW
British journal of pharmacology 2020 Jan;177(2):372-387

Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury.

Zhang N, Zhang Y, Wu B, You S, Sun Y
Redox biology 2020 Feb;30:101419

WWP2 ameliorates acute kidney injury by mediating p53 ubiquitylation and degradation.

Che H, He W, Feng J, Dong W, Liu S, Chen T, Ge S, Zhou J, Liang C
Cell biochemistry and function 2020 Aug;38(6):695-701

WWP2 regulates SIRT1-STAT3 acetylation and phosphorylation involved in hypertensive angiopathy.

Zhang Y, You S, Tian Y, Lu S, Cao L, Sun Y, Zhang N
Journal of cellular and molecular medicine 2020 Aug;24(16):9041-9054

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse liver tissue were subjected to SDS PAGE followed by western blot with 12197-1-AP(WWP2 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The WWP2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human WWP2. This antibody recognizes human, mouse antigen. The WWP2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 12197-1-AP.pdf

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