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- References [15]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 12197-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12197-1-AP, RRID:AB_10597536
- Product name
- WWP2 antibody
- Antibody type
- Polyclonal
- Description
- WWP2 antibody (Cat. #12197-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references WWP2 protects against sepsis-induced cardiac injury through inhibiting cardiomyocyte ferroptosis.
Atorvastatin rescues vascular endothelial injury in hypertension by WWP2-mediated ubiquitination and degradation of ATP5A.
Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X.
High dose isoleucine stabilizes nuclear PTEN to suppress the proliferation of lung cancer.
WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein.
14-3-3σ-NEDD4L axis promotes ubiquitination and degradation of HIF-1α in colorectal cancer.
miR-328-5p Induces Human Intervertebral Disc Degeneration by Targeting WWP2.
The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia.
A WWP2-PTEN-KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice.
WWP2 Promotes Odontoblastic Differentiation by Monoubiquitinating KLF5.
Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling.
Costunolide represses hepatic fibrosis through WW domain-containing protein 2-mediated Notch3 degradation.
Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury.
WWP2 ameliorates acute kidney injury by mediating p53 ubiquitylation and degradation.
WWP2 regulates SIRT1-STAT3 acetylation and phosphorylation involved in hypertensive angiopathy.
Li Z, Wu B, Chen J, Ye N, Ma R, Song C, Sun Y, Zhang X, Sun G
Journal of translational internal medicine 2024 Feb;12(1):35-50
Journal of translational internal medicine 2024 Feb;12(1):35-50
Atorvastatin rescues vascular endothelial injury in hypertension by WWP2-mediated ubiquitination and degradation of ATP5A.
Yin Z, You S, Zhang S, Zhang L, Wu B, Huang X, Lu S, Cao L, Zhang Y, Li D, Zhang X, Liu J, Sun Y, Zhang N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115228
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115228
Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X.
You S, Xu J, Yin Z, Wu B, Wang P, Hao M, Cheng C, Liu M, Zhao Y, Jia P, Jiang H, Li D, Cao L, Zhang X, Zhang Y, Sun Y, Zhang N
Cardiovascular diabetology 2023 May 6;22(1):107
Cardiovascular diabetology 2023 May 6;22(1):107
High dose isoleucine stabilizes nuclear PTEN to suppress the proliferation of lung cancer.
Wang H, Chen S, Kang W, Ding B, Cui S, Zhou L, Zhang N, Luo H, Wang M, Zhang F, Zhao Z, Guo Z, Wang C, Li L, Wang Z, Chen X, Wang Y
Discover oncology 2023 Feb 23;14(1):25
Discover oncology 2023 Feb 23;14(1):25
WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein.
Zou J, Zhou L, Le Y, Fang Z, Zhong M, Nie F, Wei X, Zhang X, Chen Z, Cai L, Wang H, Xiong J, Fang Z, Xiang X
Cell communication and signaling : CCS 2023 Feb 17;21(1):38
Cell communication and signaling : CCS 2023 Feb 17;21(1):38
14-3-3σ-NEDD4L axis promotes ubiquitination and degradation of HIF-1α in colorectal cancer.
Liu S, Guo R, Xu H, Yang J, Luo H, Yeung SJ, Li K, Lee MH, Yang R
Cell reports 2023 Aug 29;42(8):112870
Cell reports 2023 Aug 29;42(8):112870
miR-328-5p Induces Human Intervertebral Disc Degeneration by Targeting WWP2.
Yan J, Wu LG, Zhang M, Fang T, Pan W, Zhao JL, Zhou Q
Oxidative medicine and cellular longevity 2022;2022:3511967
Oxidative medicine and cellular longevity 2022;2022:3511967
The role of E3 ubiquitin ligase WWP2 and the regulation of PARP1 by ubiquitinated degradation in acute lymphoblastic leukemia.
Lu X, Huang X, Xu H, Lu S, You S, Xu J, Zhan Q, Dong C, Zhang N, Zhang Y, Cao L, Zhang X, Zhang N, Zhang L
Cell death discovery 2022 Oct 18;8(1):421
Cell death discovery 2022 Oct 18;8(1):421
A WWP2-PTEN-KLF5 signaling axis regulates odontoblast differentiation and dentinogenesis in mice.
Fu J, Zhang X, Zheng H, Yang G, Chen Z, Yuan G
The Journal of biological chemistry 2022 Aug;298(8):102220
The Journal of biological chemistry 2022 Aug;298(8):102220
WWP2 Promotes Odontoblastic Differentiation by Monoubiquitinating KLF5.
Fu J, Zheng H, Xue Y, Jin R, Yang G, Chen Z, Yuan G
Journal of dental research 2021 Apr;100(4):432-439
Journal of dental research 2021 Apr;100(4):432-439
Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling.
Zhang N, Zhang Y, Qian H, Wu S, Cao L, Sun Y
Cell death and differentiation 2020 Sep;27(9):2605-2619
Cell death and differentiation 2020 Sep;27(9):2605-2619
Costunolide represses hepatic fibrosis through WW domain-containing protein 2-mediated Notch3 degradation.
Ge MX, Liu HT, Zhang N, Niu WX, Lu ZN, Bao YY, Huang R, Yu DK, Shao RG, He HW
British journal of pharmacology 2020 Jan;177(2):372-387
British journal of pharmacology 2020 Jan;177(2):372-387
Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury.
Zhang N, Zhang Y, Wu B, You S, Sun Y
Redox biology 2020 Feb;30:101419
Redox biology 2020 Feb;30:101419
WWP2 ameliorates acute kidney injury by mediating p53 ubiquitylation and degradation.
Che H, He W, Feng J, Dong W, Liu S, Chen T, Ge S, Zhou J, Liang C
Cell biochemistry and function 2020 Aug;38(6):695-701
Cell biochemistry and function 2020 Aug;38(6):695-701
WWP2 regulates SIRT1-STAT3 acetylation and phosphorylation involved in hypertensive angiopathy.
Zhang Y, You S, Tian Y, Lu S, Cao L, Sun Y, Zhang N
Journal of cellular and molecular medicine 2020 Aug;24(16):9041-9054
Journal of cellular and molecular medicine 2020 Aug;24(16):9041-9054
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 12197-1-AP(WWP2 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The WWP2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human WWP2. This antibody recognizes human, mouse antigen. The WWP2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
