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Learn22490-1-AP
antibody from Proteintech Group
Targeting: CEP290
3H11Ag, BBS14, CT87, FLJ13615, JBTS5, KIAA0373, LCA10, MKS4, NPHP6, POC3, rd16, SLSN6
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [14]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 22490-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#22490-1-AP, RRID:AB_10973679
- Product name
- CEP290 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CEP290 antibody (Cat. #22490-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Fine-tuning FAM161A gene augmentation therapy to restore retinal function.
iU-ExM: nanoscopy of organelles and tissues with iterative ultrastructure expansion microscopy.
TTBK2 controls cilium stability by regulating distinct modules of centrosomal proteins.
The mechanism of acentrosomal spindle assembly in human oocytes.
Centrosomal protein 290 is a novel prognostic indicator that modulates liver cancer cell ferroptosis via the Nrf2 pathway.
The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic.
Phylogenetic profiling and cellular analyses of ARL16 reveal roles in traffic of IFT140 and INPP5E.
Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy.
Centrosomal and ciliary targeting of CCDC66 requires cooperative action of centriolar satellites, microtubules and molecular motors.
Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation.
The myosin-tail homology domain of centrosomal protein 290 is essential for protein confinement between the inner and outer segments in photoreceptors.
A CEP290 C-Terminal Domain Complements the Mutant CEP290 of Rd16 Mice In Trans and Rescues Retinal Degeneration.
The small GTPase RSG1 controls a final step in primary cilia initiation.
DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle.
Arsenijevic Y, Chang N, Mercey O, El Fersioui Y, Koskiniemi-Kuendig H, Joubert C, Bemelmans AP, Rivolta C, Banin E, Sharon D, Guichard P, Hamel V, Kostic C
EMBO molecular medicine 2024 Apr;16(4):805-822
EMBO molecular medicine 2024 Apr;16(4):805-822
iU-ExM: nanoscopy of organelles and tissues with iterative ultrastructure expansion microscopy.
Louvel V, Haase R, Mercey O, Laporte MH, Eloy T, Baudrier É, Fortun D, Soldati-Favre D, Hamel V, Guichard P
Nature communications 2023 Nov 30;14(1):7893
Nature communications 2023 Nov 30;14(1):7893
TTBK2 controls cilium stability by regulating distinct modules of centrosomal proteins.
Nguyen A, Goetz SC
Molecular biology of the cell 2023 Jan 1;34(1):ar8
Molecular biology of the cell 2023 Jan 1;34(1):ar8
The mechanism of acentrosomal spindle assembly in human oocytes.
Wu T, Dong J, Fu J, Kuang Y, Chen B, Gu H, Luo Y, Gu R, Zhang M, Li W, Dong X, Sun X, Sang Q, Wang L
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361
Centrosomal protein 290 is a novel prognostic indicator that modulates liver cancer cell ferroptosis via the Nrf2 pathway.
Shan Y, Yang G, Lu Q, Hu X, Qi D, Zhou Y, Xiao Y, Cao L, Tian F, Pan Q
Aging 2022 Mar 10;14(5):2367-2382
Aging 2022 Mar 10;14(5):2367-2382
The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic.
Turn RE, Hu Y, Dewees SI, Devi N, East MP, Hardin KR, Khatib T, Linnert J, Wolfrum U, Lim MJ, Casanova JE, Caspary T, Kahn RA
Molecular biology of the cell 2022 Feb 1;33(2):ar13
Molecular biology of the cell 2022 Feb 1;33(2):ar13
Phylogenetic profiling and cellular analyses of ARL16 reveal roles in traffic of IFT140 and INPP5E.
Dewees SI, Vargová R, Hardin KR, Turn RE, Devi S, Linnert J, Wolfrum U, Caspary T, Eliáš M, Kahn RA
Molecular biology of the cell 2022 Apr 1;33(4):ar33
Molecular biology of the cell 2022 Apr 1;33(4):ar33
Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy.
Martello A, Lauriola A, Mellis D, Parish E, Dawson JC, Imrie L, Vidmar M, Gammoh N, Mitić T, Brittan M, Mills NL, Carragher NO, D'Arca D, Caporali A
EMBO reports 2020 Jul 3;21(7):e48192
EMBO reports 2020 Jul 3;21(7):e48192
Centrosomal and ciliary targeting of CCDC66 requires cooperative action of centriolar satellites, microtubules and molecular motors.
Conkar D, Bayraktar H, Firat-Karalar EN
Scientific reports 2019 Oct 3;9(1):14250
Scientific reports 2019 Oct 3;9(1):14250
Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation.
Odabasi E, Gul S, Kavakli IH, Firat-Karalar EN
EMBO reports 2019 Jun;20(6)
EMBO reports 2019 Jun;20(6)
The myosin-tail homology domain of centrosomal protein 290 is essential for protein confinement between the inner and outer segments in photoreceptors.
Datta P, Hendrickson B, Brendalen S, Ruffcorn A, Seo S
The Journal of biological chemistry 2019 Dec 13;294(50):19119-19136
The Journal of biological chemistry 2019 Dec 13;294(50):19119-19136
A CEP290 C-Terminal Domain Complements the Mutant CEP290 of Rd16 Mice In Trans and Rescues Retinal Degeneration.
Mookherjee S, Chen HY, Isgrig K, Yu W, Hiriyanna S, Levron R, Li T, Colosi P, Chien W, Swaroop A, Wu Z
Cell reports 2018 Oct 16;25(3):611-623.e6
Cell reports 2018 Oct 16;25(3):611-623.e6
The small GTPase RSG1 controls a final step in primary cilia initiation.
Agbu SO, Liang Y, Liu A, Anderson KV
The Journal of cell biology 2018 Jan 2;217(1):413-427
The Journal of cell biology 2018 Jan 2;217(1):413-427
DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle.
Zhang B, Wang G, Xu X, Yang S, Zhuang T, Wang G, Ren H, Cheng SY, Jiang Q, Zhang C
The Journal of biological chemistry 2017 Jan 27;292(4):1351-1360
The Journal of biological chemistry 2017 Jan 27;292(4):1351-1360
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 22490-1-AP(CEP290 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP result of anti-CEP290(22490-1-AP for IP and Detection).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human placenta using 22490-1-AP(CEP290 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
