Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [247]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 11562-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11562-1-AP, RRID:AB_2189084
- Product name
- SIX2 antibody
- Antibody type
- Polyclonal
- Description
- SIX2 antibody (Cat. #11562-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease.
Nephron progenitors rhythmically alternate between renewal and differentiation phases that synchronize with kidney branching morphogenesis.
Human Nephrogenesis can Persist Beyond 40 Postnatal Days in Preterm Infants.
Measurement of adhesion and traction of cells at high yield (MATCHY) reveals an energetic ratchet driving nephron condensation.
The Impact of Low Protein Diet on the Molecular and Cellular Development of the Fetal Kidney.
Characterizing expression pattern of Six2Cre during mouse craniofacial development.
Reduced nephron endowment in the common Six2-TGC (tg) mouse line is due to Six3 misexpression by aberrant enhancer-promoter interactions in the transgene.
Thyroid hormone treatment counteracts cellular phenotypical remodeling in diabetic organs.
Characterizing post-branching nephrogenesis in the neonatal rabbit.
Acetyl-CoA is a key molecule for nephron progenitor cell pool maintenance.
RBFOX2 regulated EYA3 isoforms partner with SIX4 or ZBTB1 to control transcription during myogenesis.
Rho/ROCK activity tunes cell compartment segregation and differentiation in nephron-forming niches.
Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids.
Growth and differentiation of human induced pluripotent stem cell (hiPSC)-derived kidney organoids using fully synthetic peptide hydrogels.
Fgf8 promotes survival of nephron progenitors by regulating BAX/BAK-mediated apoptosis.
Cryopreservation of Fetal Porcine Kidneys for Xenogeneic Regenerative Medicine.
Functional maturation of kidney organoid tubules: PIEZO1-mediated Ca(2+) signaling.
ASH2L Controls Ureteric Bud Morphogenesis through the Regulation of RET/GFRA1 Signaling Activity in a Mouse Model.
Identification and Characterization of the Wilms Tumor Cancer Stem Cell.
The developing murine kidney actively negotiates geometric packing conflicts to avoid defects.
ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis.
Geometric effects position renal vesicles during kidney development.
Aberrant centrosome biogenesis disrupts nephron progenitor cell renewal and fate resulting in fibrocystic kidney disease.
Isthmin-1 (Ism1) modulates renal branching morphogenesis and mesenchyme condensation during early kidney development.
Beneficial Impact of Interspecies Chimeric Renal Organoids Against a Xenogeneic Immune Response.
Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery.
Merkel Cell Carcinoma Sensitivity to EZH2 Inhibition Is Mediated by SIX1 Derepression.
Omics profiling identifies the regulatory functions of the MAPK/ERK pathway in nephron progenitor metabolism.
Foxc1 and Foxc2 are indispensable for the maintenance of nephron and stromal progenitors in the developing kidney.
Determining epigenetic memory in kidney proximal tubule cell derived induced pluripotent stem cells using a quadruple transgenic reprogrammable mouse.
Adult Mouse Kidney Stem Cells Orchestrate the De Novo Assembly of a Nephron via Sirt2-Modulated Canonical Wnt/β-Catenin Signaling.
Deciphering the minimal quantity of mouse primary cells to undergo nephrogenesis ex vivo.
Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair.
Generation of functional chimeric kidney containing exogenous progenitor-derived stroma and nephron via a conditional empty niche.
Podocytes derived from human induced pluripotent stem cells: characterization, comparison, and modeling of diabetic kidney disease.
Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis.
Inhibition of O-GlcNAcylation protects from Shiga toxin-mediated cell injury and lethality in host.
An organ-derived extracellular matrix triggers in situ kidney regeneration in a preclinical model.
Multispectral confocal 3D imaging of intact healthy and tumor tissue using mLSR-3D.
Development of a Cryopreservation Technique for Xenogeneic Kidney Grafts: Evaluation Using a Mouse Model.
Directed Differentiation of Human Pluripotent Stem Cells for the Generation of High-Order Kidney Organoids.
Impact of gestational low-protein intake on embryonic kidney microRNA expression and in nephron progenitor cells of the male fetus.
Gestational Low Protein Diet Modulation on miRNA Transcriptome and Its Target During Fetal and Breastfeeding Nephrogenesis.
Revealing the spatio-phenotypic patterning of cells in healthy and tumor tissues with mLSR-3D and STAPL-3D.
Generation of Urine-Derived Induced Pluripotent Stem Cell Line from Patients with Acute Kidney Injury.
Chromatin Remodelers Interact with Eya1 and Six2 to Target Enhancers to Control Nephron Progenitor Cell Maintenance.
Targeted disruption of the histone lysine 79 methyltransferase Dot1L in nephron progenitors causes congenital renal dysplasia.
Premature differentiation of nephron progenitor cell and dysregulation of gene pathways critical to kidney development in a model of preterm birth.
Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis.
A tissue-bioengineering strategy for modeling rare human kidney diseases in vivo.
The embryonic ontogeny of the gonadal somatic cells in mice and monkeys.
The Rhesus Macaque Serves As a Model for Human Lateral Branch Nephrogenesis.
Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF.
Kidney epithelial targeted mitochondrial transcription factor A deficiency results in progressive mitochondrial depletion associated with severe cystic disease.
In vivo regeneration of neo-nephrons in rodents by renal progenitor cell transplantation.
Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors.
A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells.
Post-translational modifications by SIRT3 de-2-hydroxyisobutyrylase activity regulate glycolysis and enable nephrogenesis.
Loss of Planar Cell Polarity Effector Fuzzy Causes Renal Hypoplasia by Disrupting Several Signaling Pathways.
Accelerated protocol for the differentiation of podocytes from human pluripotent stem cells.
BET Proteins Regulate Expression of Osr1 in Early Kidney Development.
Increasing mTORC1 Pathway Activity or Methionine Supplementation during Pregnancy Reverses the Negative Effect of Maternal Malnutrition on the Developing Kidney.
Spatial transcriptional mapping of the human nephrogenic program.
Promoting Maturation of Human Pluripotent Stem Cell-Derived Renal Microtissue by Incorporation of Endothelial and Mesenchymal Cells.
Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development.
Recapitulating kidney development in vitro by priming and differentiating mouse embryonic stem cells in monolayers.
Gen1 mutation caused kidney hypoplasia and defective ureter-bladder connections in mice.
Folic acid supplementation alleviates reduced ureteric branching, nephrogenesis, and global DNA methylation induced by maternal nutrient restriction in rat embryonic kidney.
Prenatal hypoxia increases susceptibility to kidney injury.
CexE Is a Coat Protein and Virulence Factor of Diarrheagenic Pathogens.
Mdm4 controls ureteric bud branching via regulation of p53 activity.
Generation of Human Renal Vesicles in Mouse Organ Niche Using Nephron Progenitor Cell Replacement System.
Nephron Progenitor Maintenance Is Controlled through Fibroblast Growth Factors and Sprouty1 Interaction.
ADAM10 mediates ectopic proximal tubule development and renal fibrosis through Notch signalling.
SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro.
Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids.
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.
Mutational analysis of genes with ureteric progenitor cell-specific expression in branching morphogenesis of the mouse kidney.
Generation and characterization of Six2 conditional mice.
Stromal β-catenin activation impacts nephron progenitor differentiation in the developing kidney and may contribute to Wilms tumor.
Deletion in the Cobalamin Synthetase W Domain-Containing Protein 1 Gene Is associated with Congenital Anomalies of the Kidney and Urinary Tract.
Six2 regulates Pax9 expression, palatogenesis and craniofacial bone formation.
Genetic manipulation of ureteric bud tip progenitors in the mammalian kidney through an Adamts18 enhancer driven tet-on inducible system.
The polycomb proteins EZH1 and EZH2 co-regulate chromatin accessibility and nephron progenitor cell lifespan in mice.
Identification and characterization of cellular heterogeneity within the developing renal interstitium.
Deletion of hypoxia-responsive microRNA-210 results in a sex-specific decrease in nephron number.
A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells.
Three Optimized Methods for In Situ Quantification of Progenitor Cell Proliferation in Embryonic Kidneys Using BrdU, EdU, and PCNA.
Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells.
Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network.
Molecular characterization of nephron progenitors and their early epithelial derivative structures in the nephrogenic zone of the canine fetal kidney.
Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes.
Transcription factor Six2 induces a stem cell-like phenotype in renal cell carcinoma cells.
A Toolbox to Characterize Human Induced Pluripotent Stem Cell-Derived Kidney Cell Types and Organoids.
Morphogenesis of the kidney and lung requires branch-tip directed activity of the Adamts18 metalloprotease.
Tumor-suppressive activity of Hnf1β in Wilms' tumor.
In utero exposure to maternal diabetes impairs nephron progenitor differentiation.
Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development.
Disabling of nephrogenesis in porcine embryos via CRISPR/Cas9-mediated SIX1 and SIX4 gene targeting.
In vivo regeneration of interspecies chimeric kidneys using a nephron progenitor cell replacement system.
Anephrogenic phenotype induced by SALL1 gene knockout in pigs.
Stromal prorenin receptor is critical for normal kidney development.
Loss of miR-17~92 results in dysregulation of Cftr in nephron progenitors.
Tubuloids derived from human adult kidney and urine for personalized disease modeling.
Platforms of in vivo genome editing with inducible Cas9 for advanced cancer modeling.
FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling.
Loss-of-function mutations in KIF14 cause severe microcephaly and kidney development defects in humans and zebrafish.
Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk.
PPARG Negatively Modulates Six2 in Tumor Formation of Clear Cell Renal Cell Carcinoma.
Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation.
DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.
Nephron progenitor commitment is a stochastic process influenced by cell migration.
Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis.
Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development.
Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats.
Reconstitution of the embryonic kidney identifies a donor cell contribution to the renal vasculature upon transplantation.
Six2 is negatively correlated with prognosis and facilitates epithelial-mesenchymal transition via TGF-β/Smad signal pathway in hepatocellular carcinoma.
Forty-five patient-derived xenografts capture the clinical and biological heterogeneity of Wilms tumor.
Molecular determinants of nephron vascular specialization in the kidney.
A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB.
DNMT1 in Six2 Progenitor Cells Is Essential for Transposable Element Silencing and Kidney Development.
Reporter-based fate mapping in human kidney organoids confirms nephron lineage relationships and reveals synchronous nephron formation.
Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells.
Ex vivo live cell tracking in kidney organoids using light sheet fluorescence microscopy.
Gulo regulates the proliferation, apoptosis and mesenchymal-to-epithelial transformation of metanephric mesenchyme cells via inhibiting Six2.
Maternal malnourishment induced upregulation of fetuin-B blunts nephrogenesis in the low birth weight neonate.
Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT).
Histone deacetylases 1 and 2 regulate the transcriptional programs of nephron progenitors and renal vesicles.
Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number.
Reduced Abd-B Hox function during kidney development results in lineage infidelity.
Hedgehog-GLI signaling in Foxd1-positive stromal cells promotes murine nephrogenesis via TGFβ signaling.
Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration.
An optimal serum-free defined condition for in vitro culture of kidney organoids.
Centrosome amplification disrupts renal development and causes cystogenesis.
EED, a member of the polycomb group, is required for nephron differentiation and the maintenance of nephron progenitor cells.
Ectopic Phosphorylated Creb Marks Dedifferentiated Proximal Tubules in Cystic Kidney Disease.
Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies.
Optimal route of diphtheria toxin administration to eliminate native nephron progenitor cells in vivo for kidney regeneration.
Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment.
Six2 is negatively correlated with good prognosis and decreases 5-FU sensitivity via suppressing E-cadherin expression in hepatocellular carcinoma cells.
Six2 Plays an Intrinsic Role in Regulating Proliferation of Mesenchymal Cells in the Developing Palate.
Effect of Hypoxia on the Differentiation and the Self-Renewal of Metanephrogenic Mesenchymal Stem Cells.
The developmental programme for genesis of the entire kidney is recapitulated in Wilms tumour.
Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium.
A Novel Method for Isolation of Pluripotent Stem Cells from Human Umbilical Cord Blood.
LIM kinase function and renal growth: Potential role for LIM kinases in fetal programming of kidney development.
Regulation of Nephron Progenitor Cell Self-Renewal by Intermediary Metabolism.
Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system.
Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice.
Myc cooperates with β-catenin to drive gene expression in nephron progenitor cells.
Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Lats1/2 Regulate Yap/Taz to Control Nephron Progenitor Epithelialization and Inhibit Myofibroblast Formation.
Tridimensional Visualization and Analysis of Early Human Development.
Novel fixed z-direction (FiZD) kidney primordia and an organoid culture system for time-lapse confocal imaging.
Self-organisation after embryonic kidney dissociation is driven via selective adhesion of ureteric epithelial cells.
Cycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney.
Evidence of In Vitro Preservation of Human Nephrogenesis at the Single-Cell Level.
Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells.
Repair after nephron ablation reveals limitations of neonatal neonephrogenesis.
Temporally Distinct Six2-Positive Second Heart Field Progenitors Regulate Mammalian Heart Development and Disease.
In Vitro Propagation and Branching Morphogenesis from Single Ureteric Bud Cells.
Derivation and characterization of integration-free iPSC line ISRM-UM51 derived from SIX2-positive renal cells isolated from urine of an African male expressing the CYP2D6 *4/*17 variant which confers intermediate drug metabolizing activity.
Refuting the hypothesis that semaphorin-3f/neuropilin-2 exclude blood vessels from the cap mesenchyme in the developing kidney.
Higher-Order Kidney Organogenesis from Pluripotent Stem Cells.
In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation.
Low birth weight is associated with impaired murine kidney development and function.
BMP7 dose-dependently stimulates proliferation and cadherin-11 expression via ERK and p38 in a murine metanephric mesenchymal cell line.
Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development.
Acellular Mouse Kidney ECM can be Used as a Three-Dimensional Substrate to Test the Differentiation Potential of Embryonic Stem Cell Derived Renal Progenitors.
TβRII Regulates the Proliferation of Metanephric Mesenchyme Cells through Six2 In Vitro.
Osr1 Interacts Synergistically with Wt1 to Regulate Kidney Organogenesis.
Characterisation of Cultured Mesothelial Cells Derived from the Murine Adult Omentum.
Postembryonic Nephrogenesis and Persistence of Six2-Expressing Nephron Progenitor Cells in the Reptilian Kidney.
Six2 Is a Coordinator of LiCl-Induced Cell Proliferation and Apoptosis.
Cap mesenchyme cell swarming during kidney development is influenced by attraction, repulsion, and adhesion to the ureteric tip.
Notch signaling promotes nephrogenesis by downregulating Six2.
Preserved Nephrogenesis Following Partial Nephrectomy in Early Neonates.
Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.
Prorenin receptor is critical for nephron progenitors.
Nephron Progenitor But Not Stromal Progenitor Cells Give Rise to Wilms Tumors in Mouse Models with β-Catenin Activation or Wt1 Ablation and Igf2 Upregulation.
Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor.
Zeb1 Is a Potential Regulator of Six2 in the Proliferation, Apoptosis and Migration of Metanephric Mesenchyme Cells.
A critical role for NF2 and the Hippo pathway in branching morphogenesis.
Selective In Vitro Propagation of Nephron Progenitors Derived from Embryos and Pluripotent Stem Cells.
Maintenance of Mouse Nephron Progenitor Cells in Aggregates with Gamma-Secretase Inhibitor.
Stromally expressed β-catenin modulates Wnt9b signaling in the ureteric epithelium.
Natural Scaffolds for Renal Differentiation of Human Embryonic Stem Cells for Kidney Tissue Engineering.
Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival.
Sall1 in renal stromal progenitors non-cell autonomously restricts the excessive expansion of nephron progenitors.
Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis.
Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan.
Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons.
Single adult kidney stem/progenitor cells reconstitute three-dimensional nephron structures in vitro.
A Cre-inducible fluorescent reporter for observing apical membrane dynamics.
Renal progenitors derived from human iPSCs engraft and restore function in a mouse model of acute kidney injury.
A synthetic niche for nephron progenitor cells.
Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development.
Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells.
Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development.
A developmentally plastic adult mouse kidney cell line spontaneously generates multiple adult kidney structures.
Fat4/Dchs1 signaling between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching.
Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool.
Fibroblast growth factor receptor-Frs2α signaling is critical for nephron progenitors.
WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals.
Ablation of the renal stroma defines its critical role in nephron progenitor and vasculature patterning.
miR181c promotes apoptosis and suppresses proliferation of metanephric mesenchyme cells by targeting Six2 in vitro.
The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor-like cells.
Sall1 maintains nephron progenitors and nascent nephrons by acting as both an activator and a repressor.
Down-regulated Six2 by knockdown of neurofibromin results in apoptosis of metanephric mesenchyme cells in vitro.
β-Catenin overexpression in the metanephric mesenchyme leads to renal dysplasia genesis via cell-autonomous and non-cell-autonomous mechanisms.
Lin28 sustains early renal progenitors and induces Wilms tumor.
Mdm2 is required for maintenance of the nephrogenic niche.
Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers.
Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney.
Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells.
In situ histone landscape of nephrogenesis.
Aberrant activation, nuclear localization, and phosphorylation of Yes-associated protein-1 in the embryonic kidney and Wilms tumor.
An integrated pipeline for the multidimensional analysis of branching morphogenesis.
Identification and characterization of retinoic acid-responsive genes in mouse kidney development.
Single cell dissection of early kidney development: multilineage priming.
Renal blood flow and oxygenation drive nephron progenitor differentiation.
Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis.
Global quantification of tissue dynamics in the developing mouse kidney.
The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment.
Dicer function is required in the metanephric mesenchyme for early kidney development.
Sall4 Is Transiently Expressed in the Caudal Wolffian Duct and the Ureteric Bud, but Dispensable for Kidney Development.
Endothelial Progenitors Exist within the Kidney and Lung Mesenchyme.
Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation.
Stage specific requirement of Gfrα1 in the ureteric epithelium during kidney development.
MiR-181b targets Six2 and inhibits the proliferation of metanephric mesenchymal cells in vitro.
Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development.
Scaffolding proteins DLG1 and CASK cooperate to maintain the nephron progenitor population during kidney development.
Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells.
Six homeoproteins directly activate Myod expression in the gene regulatory networks that control early myogenesis.
Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks.
Development of embryonic stem cells in recombinant kidneys.
Integration potential of mouse and human bone marrow-derived mesenchymal stem cells.
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.
COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival.
Ureteric morphogenesis requires Fgfr1 and Fgfr2/Frs2α signaling in the metanephric mesenchyme.
Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice.
The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification.
Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching.
Alk3 controls nephron number and androgen production via lineage-specific effects in intermediate mesoderm.
Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development.
Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network.
Misexpression of Six2 is associated with heritable frontonasal dysplasia and renal hypoplasia in 3H1 Br mice.
Huang B, Zeng Z, Kim S, Fausto CC, Koppitch K, Li H, Li Z, Chen X, Guo J, Zhang CC, Ma T, Medina P, Schreiber ME, Xia MW, Vonk AC, Xiang T, Patel T, Li Y, Parvez RK, Der B, Chen JH, Liu Z, Thornton ME, Grubbs BH, Diao Y, Dou Y, Gnedeva K, Ying Q, Pastor-Soler NM, Fei T, Hallows KR, Lindström NO, McMahon AP, Li Z
Cell stem cell 2024 Jun 6;31(6):921-939.e17
Cell stem cell 2024 Jun 6;31(6):921-939.e17
Nephron progenitors rhythmically alternate between renewal and differentiation phases that synchronize with kidney branching morphogenesis.
Davis SN, Grindel SH, Viola JM, Liu GY, Liu J, Qian G, Porter CM, Hughes AJ
bioRxiv : the preprint server for biology 2024 Jan 13;
bioRxiv : the preprint server for biology 2024 Jan 13;
Human Nephrogenesis can Persist Beyond 40 Postnatal Days in Preterm Infants.
Carpenter J, Yarlagadda S, VandenHeuvel KA, Ding L, Schuh MP
Kidney international reports 2024 Feb;9(2):436-450
Kidney international reports 2024 Feb;9(2):436-450
Measurement of adhesion and traction of cells at high yield (MATCHY) reveals an energetic ratchet driving nephron condensation.
Liu J, Prahl LS, Huang A, Hughes AJ
bioRxiv : the preprint server for biology 2024 Feb 8;
bioRxiv : the preprint server for biology 2024 Feb 8;
The Impact of Low Protein Diet on the Molecular and Cellular Development of the Fetal Kidney.
Short KM, Tortelote GG, Jones LK, Diniz F, Edgington-Giordano F, Cullen-McEwen LA, Schröder J, Spencer A, Keniry A, Polo JM, Bertram JF, Blewitt ME, Smyth IM, El-Dahr SS
bioRxiv : the preprint server for biology 2024 Aug 19;
bioRxiv : the preprint server for biology 2024 Aug 19;
Characterizing expression pattern of Six2Cre during mouse craniofacial development.
Umar M, Dong C, He F
Genesis (New York, N.Y. : 2000) 2023 Sep;61(5):e23516
Genesis (New York, N.Y. : 2000) 2023 Sep;61(5):e23516
Reduced nephron endowment in the common Six2-TGC (tg) mouse line is due to Six3 misexpression by aberrant enhancer-promoter interactions in the transgene.
Perl AJ, Liu H, Hass M, Adhikari N, Chaturvedi P, Hu YC, Jiang R, Liu Y, Kopan R
bioRxiv : the preprint server for biology 2023 Oct 9;
bioRxiv : the preprint server for biology 2023 Oct 9;
Thyroid hormone treatment counteracts cellular phenotypical remodeling in diabetic organs.
Lavecchia AM, Mantzouratou P, Cerullo D, Locatelli M, Conti S, Tironi M, Sangalli F, Corna D, Zoja C, Remuzzi G, Xinaris C
iScience 2023 Oct 20;26(10):107826
iScience 2023 Oct 20;26(10):107826
Characterizing post-branching nephrogenesis in the neonatal rabbit.
Schuh MP, Yarlagadda S, Alkhudairy L, Preusse K, Kopan R
Scientific reports 2023 Nov 6;13(1):19234
Scientific reports 2023 Nov 6;13(1):19234
Acetyl-CoA is a key molecule for nephron progenitor cell pool maintenance.
Diniz F, Ngo NYN, Colon-Leyva M, Edgington-Giordano F, Hilliard S, Zwezdaryk K, Liu J, El-Dahr SS, Tortelote GG
Nature communications 2023 Nov 25;14(1):7733
Nature communications 2023 Nov 25;14(1):7733
RBFOX2 regulated EYA3 isoforms partner with SIX4 or ZBTB1 to control transcription during myogenesis.
Wiedner HJ, Blue RE, Sadovsky M, Mills CA, Wehrens XHT, Herring LE, Giudice J
iScience 2023 Nov 17;26(11):108258
iScience 2023 Nov 17;26(11):108258
Rho/ROCK activity tunes cell compartment segregation and differentiation in nephron-forming niches.
Viola JM, Liu J, Huang A, Grindel SH, Prahl LS, Hughes AJ
bioRxiv : the preprint server for biology 2023 Nov 10;
bioRxiv : the preprint server for biology 2023 Nov 10;
Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids.
Huang B, Zeng Z, Li H, Li Z, Chen X, Guo J, Zhang CC, Schreiber ME, Vonk AC, Xiang T, Patel T, Li Y, Parvez RK, Der B, Chen JH, Liu Z, Thornton ME, Grubbs BH, Diao Y, Dou Y, Gnedeva K, Lindström NO, Ying Q, Pastor-Soler NM, Fei T, Hallows KR, McMahon AP, Li Z
bioRxiv : the preprint server for biology 2023 May 25;
bioRxiv : the preprint server for biology 2023 May 25;
Growth and differentiation of human induced pluripotent stem cell (hiPSC)-derived kidney organoids using fully synthetic peptide hydrogels.
Treacy NJ, Clerkin S, Davis JL, Kennedy C, Miller AF, Saiani A, Wychowaniec JK, Brougham DF, Crean J
Bioactive materials 2023 Mar;21:142-156
Bioactive materials 2023 Mar;21:142-156
Fgf8 promotes survival of nephron progenitors by regulating BAX/BAK-mediated apoptosis.
Anderson MJ, Misaghian S, Sharma N, Perantoni AO, Lewandoski M
Differentiation; research in biological diversity 2023 Mar-Apr;130:7-15
Differentiation; research in biological diversity 2023 Mar-Apr;130:7-15
Cryopreservation of Fetal Porcine Kidneys for Xenogeneic Regenerative Medicine.
Matsui K, Kinoshita Y, Inage Y, Matsumoto N, Morimoto K, Saito Y, Takamura T, Matsunari H, Yamanaka S, Nagashima H, Kobayashi E, Yokoo T
Journal of clinical medicine 2023 Mar 15;12(6)
Journal of clinical medicine 2023 Mar 15;12(6)
Functional maturation of kidney organoid tubules: PIEZO1-mediated Ca(2+) signaling.
Carrisoza-Gaytan R, Kroll KT, Hiratsuka K, Gupta NR, Morizane R, Lewis JA, Satlin LM
American journal of physiology. Cell physiology 2023 Mar 1;324(3):C757-C768
American journal of physiology. Cell physiology 2023 Mar 1;324(3):C757-C768
ASH2L Controls Ureteric Bud Morphogenesis through the Regulation of RET/GFRA1 Signaling Activity in a Mouse Model.
Zhao Z, Dai X, Jiang G, Lin F
Journal of the American Society of Nephrology : JASN 2023 Jun 1;34(6):988-1002
Journal of the American Society of Nephrology : JASN 2023 Jun 1;34(6):988-1002
Identification and Characterization of the Wilms Tumor Cancer Stem Cell.
Petrosyan A, Villani V, Aguiari P, Thornton ME, Wang Y, Rajewski A, Zhou S, Cravedi P, Grubbs BH, De Filippo RE, Sedrakyan S, Lemley KV, Csete M, Da Sacco S, Perin L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jul;10(20):e2206787
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jul;10(20):e2206787
The developing murine kidney actively negotiates geometric packing conflicts to avoid defects.
Prahl LS, Viola JM, Liu J, Hughes AJ
Developmental cell 2023 Jan 23;58(2):110-120.e5
Developmental cell 2023 Jan 23;58(2):110-120.e5
ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis.
Kumar S, Fan X, Rasouly HM, Sharma R, Salant DJ, Lu W
JCI insight 2023 Jan 10;8(1)
JCI insight 2023 Jan 10;8(1)
Geometric effects position renal vesicles during kidney development.
Mederacke M, Conrad L, Doumpas N, Vetter R, Iber D
Cell reports 2023 Dec 26;42(12):113526
Cell reports 2023 Dec 26;42(12):113526
Aberrant centrosome biogenesis disrupts nephron progenitor cell renewal and fate resulting in fibrocystic kidney disease.
Cheng T, Agwu C, Shim K, Wang B, Jain S, Mahjoub MR
bioRxiv : the preprint server for biology 2023 Apr 5;
bioRxiv : the preprint server for biology 2023 Apr 5;
Isthmin-1 (Ism1) modulates renal branching morphogenesis and mesenchyme condensation during early kidney development.
Gao G, Li X, Jiang Z, Osorio L, Tang YL, Yu X, Jin G, Zhou Z
Nature communications 2023 Apr 25;14(1):2378
Nature communications 2023 Apr 25;14(1):2378
Beneficial Impact of Interspecies Chimeric Renal Organoids Against a Xenogeneic Immune Response.
Saito Y, Matsumoto N, Yamanaka S, Yokoo T, Kobayashi E
Frontiers in immunology 2022;13:848433
Frontiers in immunology 2022;13:848433
Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery.
Hiratsuka K, Miyoshi T, Kroll KT, Gupta NR, Valerius MT, Ferrante T, Yamashita M, Lewis JA, Morizane R
Science advances 2022 Sep 23;8(38):eabq0866
Science advances 2022 Sep 23;8(38):eabq0866
Merkel Cell Carcinoma Sensitivity to EZH2 Inhibition Is Mediated by SIX1 Derepression.
Gartin AK, Frost TC, Cushman CH, Leeper BA, Gokhale PC, DeCaprio JA
The Journal of investigative dermatology 2022 Oct;142(10):2783-2792.e15
The Journal of investigative dermatology 2022 Oct;142(10):2783-2792.e15
Omics profiling identifies the regulatory functions of the MAPK/ERK pathway in nephron progenitor metabolism.
Kwon HN, Kurtzeborn K, Iaroshenko V, Jin X, Loh A, Escande-Beillard N, Reversade B, Park S, Kuure S
Development (Cambridge, England) 2022 Oct 1;149(19)
Development (Cambridge, England) 2022 Oct 1;149(19)
Foxc1 and Foxc2 are indispensable for the maintenance of nephron and stromal progenitors in the developing kidney.
Motojima M, Tanaka M, Kume T
Journal of cell science 2022 Oct 1;135(19)
Journal of cell science 2022 Oct 1;135(19)
Determining epigenetic memory in kidney proximal tubule cell derived induced pluripotent stem cells using a quadruple transgenic reprogrammable mouse.
Khelifi G, Chow T, Whiteley J, Fort V, Humphreys BD, Hussein SMI, Rogers IM
Scientific reports 2022 Nov 25;12(1):20340
Scientific reports 2022 Nov 25;12(1):20340
Adult Mouse Kidney Stem Cells Orchestrate the De Novo Assembly of a Nephron via Sirt2-Modulated Canonical Wnt/β-Catenin Signaling.
Han X, Sun Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 May;9(15):e2104034
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 May;9(15):e2104034
Deciphering the minimal quantity of mouse primary cells to undergo nephrogenesis ex vivo.
Rak-Raszewska A, Reint G, Geiger F, Naillat F, Vainio SJ
Developmental dynamics : an official publication of the American Association of Anatomists 2022 Mar;251(3):536-550
Developmental dynamics : an official publication of the American Association of Anatomists 2022 Mar;251(3):536-550
Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair.
Gupta N, Matsumoto T, Hiratsuka K, Garcia Saiz E, Galichon P, Miyoshi T, Susa K, Tatsumoto N, Yamashita M, Morizane R
Science translational medicine 2022 Mar 2;14(634):eabj4772
Science translational medicine 2022 Mar 2;14(634):eabj4772
Generation of functional chimeric kidney containing exogenous progenitor-derived stroma and nephron via a conditional empty niche.
Saito Y, Yamanaka S, Matsumoto N, Takamura T, Fujimoto T, Matsui K, Tajiri S, Matsumoto K, Kobayashi E, Yokoo T
Cell reports 2022 Jun 14;39(11):110933
Cell reports 2022 Jun 14;39(11):110933
Podocytes derived from human induced pluripotent stem cells: characterization, comparison, and modeling of diabetic kidney disease.
Bejoy J, Farry JM, Peek JL, Cabatu MC, Williams FM, Welch RC, Qian ES, Woodard LE
Stem cell research & therapy 2022 Jul 26;13(1):355
Stem cell research & therapy 2022 Jul 26;13(1):355
Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis.
Ungricht R, Guibbal L, Lasbennes MC, Orsini V, Beibel M, Waldt A, Cuttat R, Carbone W, Basler A, Roma G, Nigsch F, Tchorz JS, Hoepfner D, Hoppe PS
Cell stem cell 2022 Jan 6;29(1):160-175.e7
Cell stem cell 2022 Jan 6;29(1):160-175.e7
Inhibition of O-GlcNAcylation protects from Shiga toxin-mediated cell injury and lethality in host.
Lee KS, Lee J, Lee P, Jeon BC, Song MY, Kwak S, Lee J, Kim JS, Kim DJ, Kim JH, Tesh VL, Lee MS, Park SK
EMBO molecular medicine 2022 Jan 11;14(1):e14678
EMBO molecular medicine 2022 Jan 11;14(1):e14678
An organ-derived extracellular matrix triggers in situ kidney regeneration in a preclinical model.
Tajima K, Yagi H, Morisaku T, Nishi K, Kushige H, Kojima H, Higashi H, Kuroda K, Kitago M, Adachi S, Natsume T, Nishimura K, Oya M, Kitagawa Y
NPJ Regenerative medicine 2022 Feb 28;7(1):18
NPJ Regenerative medicine 2022 Feb 28;7(1):18
Multispectral confocal 3D imaging of intact healthy and tumor tissue using mLSR-3D.
van Ineveld RL, Collot R, Román MB, Pagliaro A, Bessler N, Ariese HCR, Kleinnijenhuis M, Kool M, Alieva M, Chuva de Sousa Lopes SM, Wehrens EJ, Rios AC
Nature protocols 2022 Dec;17(12):3028-3055
Nature protocols 2022 Dec;17(12):3028-3055
Development of a Cryopreservation Technique for Xenogeneic Kidney Grafts: Evaluation Using a Mouse Model.
Takamura T, Nagashima H, Matsunari H, Yamanaka S, Saito Y, Kinoshita Y, Fujimoto T, Matsumoto K, Nakano K, Okano HJ, Kobayashi E, Yokoo T
Journal of clinical medicine 2022 Dec 6;11(23)
Journal of clinical medicine 2022 Dec 6;11(23)
Directed Differentiation of Human Pluripotent Stem Cells for the Generation of High-Order Kidney Organoids.
Selfa IL, Gallo M, Montserrat N, Garreta E
Methods in molecular biology (Clifton, N.J.) 2021;2258:171-192
Methods in molecular biology (Clifton, N.J.) 2021;2258:171-192
Impact of gestational low-protein intake on embryonic kidney microRNA expression and in nephron progenitor cells of the male fetus.
Sene LB, Scarano WR, Zapparoli A, Gontijo JAR, Boer PA
PloS one 2021;16(2):e0246289
PloS one 2021;16(2):e0246289
Gestational Low Protein Diet Modulation on miRNA Transcriptome and Its Target During Fetal and Breastfeeding Nephrogenesis.
de Barros Sene L, Lamana GL, Schwambach Vieira A, Scarano WR, Gontijo JAR, Boer PA
Frontiers in physiology 2021;12:648056
Frontiers in physiology 2021;12:648056
Revealing the spatio-phenotypic patterning of cells in healthy and tumor tissues with mLSR-3D and STAPL-3D.
van Ineveld RL, Kleinnijenhuis M, Alieva M, de Blank S, Barrera Roman M, van Vliet EJ, Martínez Mir C, Johnson HR, Bos FL, Heukers R, Chuva de Sousa Lopes SM, Drost J, Dekkers JF, Wehrens EJ, Rios AC
Nature biotechnology 2021 Oct;39(10):1239-1245
Nature biotechnology 2021 Oct;39(10):1239-1245
Generation of Urine-Derived Induced Pluripotent Stem Cell Line from Patients with Acute Kidney Injury.
Jin Y, Zhang M, Li M, Zhang H, Zhang F, Zhang H, Yin Z, Zhou M, Wan X, Li R, Cao C
Cellular reprogramming 2021 Oct;23(5):290-303
Cellular reprogramming 2021 Oct;23(5):290-303
Chromatin Remodelers Interact with Eya1 and Six2 to Target Enhancers to Control Nephron Progenitor Cell Maintenance.
Li J, Xu J, Jiang H, Zhang T, Ramakrishnan A, Shen L, Xu PX
Journal of the American Society of Nephrology : JASN 2021 Nov;32(11):2815-2833
Journal of the American Society of Nephrology : JASN 2021 Nov;32(11):2815-2833
Targeted disruption of the histone lysine 79 methyltransferase Dot1L in nephron progenitors causes congenital renal dysplasia.
Wang F, Ngo J, Li Y, Liu H, Chen CH, Saifudeen Z, Sequeira-Lopez MLS, El-Dahr SS
Epigenetics 2021 Nov;16(11):1235-1250
Epigenetics 2021 Nov;16(11):1235-1250
Premature differentiation of nephron progenitor cell and dysregulation of gene pathways critical to kidney development in a model of preterm birth.
Cwiek A, Suzuki M, deRonde K, Conaway M, Bennett KM, El Dahr S, Reidy KJ, Charlton JR
Scientific reports 2021 Nov 4;11(1):21667
Scientific reports 2021 Nov 4;11(1):21667
Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis.
Jarmas AE, Brunskill EW, Chaturvedi P, Salomonis N, Kopan R
Nature communications 2021 Nov 3;12(1):6332
Nature communications 2021 Nov 3;12(1):6332
A tissue-bioengineering strategy for modeling rare human kidney diseases in vivo.
Hernandez JOR, Wang X, Vazquez-Segoviano M, Lopez-Marfil M, Sobral-Reyes MF, Moran-Horowich A, Sundberg M, Lopez-Cantu DO, Probst CK, Ruiz-Esparza GU, Giannikou K, Abdi R, Henske EP, Kwiatkowski DJ, Sahin M, Lemos DR
Nature communications 2021 Nov 11;12(1):6496
Nature communications 2021 Nov 11;12(1):6496
The embryonic ontogeny of the gonadal somatic cells in mice and monkeys.
Sasaki K, Oguchi A, Cheng K, Murakawa Y, Okamoto I, Ohta H, Yabuta Y, Iwatani C, Tsuchiya H, Yamamoto T, Seita Y, Saitou M
Cell reports 2021 May 4;35(5):109075
Cell reports 2021 May 4;35(5):109075
The Rhesus Macaque Serves As a Model for Human Lateral Branch Nephrogenesis.
Schuh MP, Alkhudairy L, Potter A, Potter SS, Chetal K, Thakkar K, Salomonis N, Kopan R
Journal of the American Society of Nephrology : JASN 2021 May 3;32(5):1097-1112
Journal of the American Society of Nephrology : JASN 2021 May 3;32(5):1097-1112
Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF.
Li H, Kurtzeborn K, Kupari J, Gui Y, Siefker E, Lu B, Mätlik K, Olfat S, Montaño-Rodríguez AR, Huh SH, Costantini F, Andressoo JO, Kuure S
Development (Cambridge, England) 2021 May 15;148(10)
Development (Cambridge, England) 2021 May 15;148(10)
Kidney epithelial targeted mitochondrial transcription factor A deficiency results in progressive mitochondrial depletion associated with severe cystic disease.
Ishii K, Kobayashi H, Taguchi K, Guan N, Li A, Tong C, Davidoff O, Tran PV, Sharma M, Chandel NS, Kapp ME, Fogo AB, Brooks CR, Haase VH
Kidney international 2021 Mar;99(3):657-670
Kidney international 2021 Mar;99(3):657-670
In vivo regeneration of neo-nephrons in rodents by renal progenitor cell transplantation.
Yamanaka S, Matsui K, Fujimoto T, Takamura T, Saito Y, Matsumoto N, Tajiri S, Matsumoto K, Yokoo T
STAR protocols 2021 Mar 19;2(1):100314
STAR protocols 2021 Mar 19;2(1):100314
Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors.
Zeng Z, Huang B, Parvez RK, Li Y, Chen J, Vonk AC, Thornton ME, Patel T, Rutledge EA, Kim AD, Yu J, Grubbs BH, McMahon JA, Pastor-Soler NM, Hallows KR, McMahon AP, Li Z
Nature communications 2021 Jun 15;12(1):3641
Nature communications 2021 Jun 15;12(1):3641
A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells.
Guo Q, Kim A, Li B, Ransick A, Bugacov H, Chen X, Lindström N, Brown A, Oxburgh L, Ren B, McMahon AP
eLife 2021 Feb 15;10
eLife 2021 Feb 15;10
Post-translational modifications by SIRT3 de-2-hydroxyisobutyrylase activity regulate glycolysis and enable nephrogenesis.
Perico L, Morigi M, Pezzotta A, Corna D, Brizi V, Conti S, Zanchi C, Sangalli F, Trionfini P, Buttò S, Xinaris C, Tomasoni S, Zoja C, Remuzzi G, Benigni A, Imberti B
Scientific reports 2021 Dec 8;11(1):23580
Scientific reports 2021 Dec 8;11(1):23580
Loss of Planar Cell Polarity Effector Fuzzy Causes Renal Hypoplasia by Disrupting Several Signaling Pathways.
Wang IY, Chung CF, Babayeva S, Sogomonian T, Torban E
Journal of developmental biology 2021 Dec 23;10(1)
Journal of developmental biology 2021 Dec 23;10(1)
Accelerated protocol for the differentiation of podocytes from human pluripotent stem cells.
Bejoy J, Qian ES, Woodard LE
STAR protocols 2021 Dec 17;2(4):100898
STAR protocols 2021 Dec 17;2(4):100898
BET Proteins Regulate Expression of Osr1 in Early Kidney Development.
Schreiber J, Liaukouskaya N, Fuhrmann L, Hauser AT, Jung M, Huber TB, Wanner N
Biomedicines 2021 Dec 10;9(12)
Biomedicines 2021 Dec 10;9(12)
Increasing mTORC1 Pathway Activity or Methionine Supplementation during Pregnancy Reverses the Negative Effect of Maternal Malnutrition on the Developing Kidney.
Makayes Y, Resnick E, Hinden L, Aizenshtein E, Shlomi T, Kopan R, Nechama M, Volovelsky O
Journal of the American Society of Nephrology : JASN 2021 Aug;32(8):1898-1912
Journal of the American Society of Nephrology : JASN 2021 Aug;32(8):1898-1912
Spatial transcriptional mapping of the human nephrogenic program.
Lindström NO, Sealfon R, Chen X, Parvez RK, Ransick A, De Sena Brandine G, Guo J, Hill B, Tran T, Kim AD, Zhou J, Tadych A, Watters A, Wong A, Lovero E, Grubbs BH, Thornton ME, McMahon JA, Smith AD, Ruffins SW, Armit C, Troyanskaya OG, McMahon AP
Developmental cell 2021 Aug 23;56(16):2381-2398.e6
Developmental cell 2021 Aug 23;56(16):2381-2398.e6
Promoting Maturation of Human Pluripotent Stem Cell-Derived Renal Microtissue by Incorporation of Endothelial and Mesenchymal Cells.
Khoshdel-Rad N, Zahmatkesh E, Moeinvaziri F, Haghparast N, Baharvand H, Aghdami N, Moghadasali R
Stem cells and development 2021 Apr;30(8):428-440
Stem cells and development 2021 Apr;30(8):428-440
Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development.
Fuhrmann L, Lindner S, Hauser AT, Höse C, Kretz O, Cohen CD, Lindenmeyer MT, Sippl W, Jung M, Huber TB, Wanner N
International journal of molecular sciences 2021 Apr 16;22(8)
International journal of molecular sciences 2021 Apr 16;22(8)
Recapitulating kidney development in vitro by priming and differentiating mouse embryonic stem cells in monolayers.
Chow T, Wong FTM, Monetti C, Nagy A, Cox B, Rogers IM
NPJ Regenerative medicine 2020;5:7
NPJ Regenerative medicine 2020;5:7
Gen1 mutation caused kidney hypoplasia and defective ureter-bladder connections in mice.
Wang X, Wang H, Liu J, Gong Y, Zhang C, Fang F, Li A, Wu X, Shen Q, Xu H
International journal of biological sciences 2020;16(9):1640-1647
International journal of biological sciences 2020;16(9):1640-1647
Folic acid supplementation alleviates reduced ureteric branching, nephrogenesis, and global DNA methylation induced by maternal nutrient restriction in rat embryonic kidney.
Awazu M, Hida M
PloS one 2020;15(4):e0230289
PloS one 2020;15(4):e0230289
Prenatal hypoxia increases susceptibility to kidney injury.
Cargill KR, Chiba T, Murali A, Mukherjee E, Crinzi E, Sims-Lucas S
PloS one 2020;15(2):e0229618
PloS one 2020;15(2):e0229618
CexE Is a Coat Protein and Virulence Factor of Diarrheagenic Pathogens.
Rivas ZP, Talbot KM, Merselis LC, McCormack RM, Adkins B, Munson GP
Frontiers in microbiology 2020;11:1374
Frontiers in microbiology 2020;11:1374
Mdm4 controls ureteric bud branching via regulation of p53 activity.
Hilliard SA, Li Y, Dixon A, El-Dahr SS
Mechanisms of development 2020 Sep;163:103616
Mechanisms of development 2020 Sep;163:103616
Generation of Human Renal Vesicles in Mouse Organ Niche Using Nephron Progenitor Cell Replacement System.
Fujimoto T, Yamanaka S, Tajiri S, Takamura T, Saito Y, Matsumoto N, Matsumoto K, Tachibana T, Okano HJ, Yokoo T
Cell reports 2020 Sep 15;32(11):108130
Cell reports 2020 Sep 15;32(11):108130
Nephron Progenitor Maintenance Is Controlled through Fibroblast Growth Factors and Sprouty1 Interaction.
Huh SH, Ha L, Jang HS
Journal of the American Society of Nephrology : JASN 2020 Nov;31(11):2559-2572
Journal of the American Society of Nephrology : JASN 2020 Nov;31(11):2559-2572
ADAM10 mediates ectopic proximal tubule development and renal fibrosis through Notch signalling.
Li B, Zhu C, Dong L, Qin J, Xiang W, Davidson AJ, Feng S, Wang Y, Shen X, Weng C, Wang C, Zhu T, Teng L, Wang J, Englert C, Chen J, Jiang H
The Journal of pathology 2020 Nov;252(3):274-289
The Journal of pathology 2020 Nov;252(3):274-289
SIX2 Regulates Human β Cell Differentiation from Stem Cells and Functional Maturation In Vitro.
Velazco-Cruz L, Goedegebuure MM, Maxwell KG, Augsornworawat P, Hogrebe NJ, Millman JR
Cell reports 2020 May 26;31(8):107687
Cell reports 2020 May 26;31(8):107687
Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids.
Kumar Gupta A, Sarkar P, Wertheim JA, Pan X, Carroll TJ, Oxburgh L
Communications biology 2020 May 11;3(1):231
Communications biology 2020 May 11;3(1):231
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.
Calandrini C, Schutgens F, Oka R, Margaritis T, Candelli T, Mathijsen L, Ammerlaan C, van Ineveld RL, Derakhshan S, de Haan S, Dolman E, Lijnzaad P, Custers L, Begthel H, Kerstens HHD, Visser LL, Rookmaaker M, Verhaar M, Tytgat GAM, Kemmeren P, de Krijger RR, Al-Saadi R, Pritchard-Jones K, Kool M, Rios AC, van den Heuvel-Eibrink MM, Molenaar JJ, van Boxtel R, Holstege FCP, Clevers H, Drost J
Nature communications 2020 Mar 11;11(1):1310
Nature communications 2020 Mar 11;11(1):1310
Mutational analysis of genes with ureteric progenitor cell-specific expression in branching morphogenesis of the mouse kidney.
Rutledge EA, McMahon AP
Developmental dynamics : an official publication of the American Association of Anatomists 2020 Jun;249(6):765-774
Developmental dynamics : an official publication of the American Association of Anatomists 2020 Jun;249(6):765-774
Generation and characterization of Six2 conditional mice.
Li C, Liu H, Hu YC, Lan Y, Jiang R
Genesis (New York, N.Y. : 2000) 2020 Jul;58(7):e23365
Genesis (New York, N.Y. : 2000) 2020 Jul;58(7):e23365
Stromal β-catenin activation impacts nephron progenitor differentiation in the developing kidney and may contribute to Wilms tumor.
Drake KA, Chaney CP, Das A, Roy P, Kwartler CS, Rakheja D, Carroll TJ
Development (Cambridge, England) 2020 Jul 31;147(21)
Development (Cambridge, England) 2020 Jul 31;147(21)
Deletion in the Cobalamin Synthetase W Domain-Containing Protein 1 Gene Is associated with Congenital Anomalies of the Kidney and Urinary Tract.
Kanda S, Ohmuraya M, Akagawa H, Horita S, Yoshida Y, Kaneko N, Sugawara N, Ishizuka K, Miura K, Harita Y, Yamamoto T, Oka A, Araki K, Furukawa T, Hattori M
Journal of the American Society of Nephrology : JASN 2020 Jan;31(1):139-147
Journal of the American Society of Nephrology : JASN 2020 Jan;31(1):139-147
Six2 regulates Pax9 expression, palatogenesis and craniofacial bone formation.
Sweat YY, Sweat M, Mansaray M, Cao H, Eliason S, Adeyemo WL, Gowans LJJ, Eshete MA, Anand D, Chalkley C, Saadi I, Lachke SA, Butali A, Amendt BA
Developmental biology 2020 Feb 15;458(2):246-256
Developmental biology 2020 Feb 15;458(2):246-256
Genetic manipulation of ureteric bud tip progenitors in the mammalian kidney through an Adamts18 enhancer driven tet-on inducible system.
Rutledge EA, Lindström NO, Michos O, McMahon AP
Developmental biology 2020 Feb 15;458(2):164-176
Developmental biology 2020 Feb 15;458(2):164-176
The polycomb proteins EZH1 and EZH2 co-regulate chromatin accessibility and nephron progenitor cell lifespan in mice.
Liu H, Hilliard S, Kelly E, Chen CH, Saifudeen Z, El-Dahr SS
The Journal of biological chemistry 2020 Aug 14;295(33):11542-11558
The Journal of biological chemistry 2020 Aug 14;295(33):11542-11558
Identification and characterization of cellular heterogeneity within the developing renal interstitium.
England AR, Chaney CP, Das A, Patel M, Malewska A, Armendariz D, Hon GC, Strand DW, Drake KA, Carroll TJ
Development (Cambridge, England) 2020 Aug 14;147(15)
Development (Cambridge, England) 2020 Aug 14;147(15)
Deletion of hypoxia-responsive microRNA-210 results in a sex-specific decrease in nephron number.
Hemker SL, Cerqueira DM, Bodnar AJ, Cargill KR, Clugston A, Anslow MJ, Sims-Lucas S, Kostka D, Ho J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5782-5799
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5782-5799
A Modular Differentiation System Maps Multiple Human Kidney Lineages from Pluripotent Stem Cells.
Tsujimoto H, Kasahara T, Sueta SI, Araoka T, Sakamoto S, Okada C, Mae SI, Nakajima T, Okamoto N, Taura D, Nasu M, Shimizu T, Ryosaka M, Li Z, Sone M, Ikeya M, Watanabe A, Osafune K
Cell reports 2020 Apr 7;31(1):107476
Cell reports 2020 Apr 7;31(1):107476
Three Optimized Methods for In Situ Quantification of Progenitor Cell Proliferation in Embryonic Kidneys Using BrdU, EdU, and PCNA.
O'Hara RE, Arsenault MG, Esparza Gonzalez BP, Patriquen A, Hartwig S
Canadian journal of kidney health and disease 2019;6:2054358119871936
Canadian journal of kidney health and disease 2019;6:2054358119871936
Constructing an Isogenic 3D Human Nephrogenic Progenitor Cell Model Composed of Endothelial, Mesenchymal, and SIX2-Positive Renal Progenitor Cells.
Nguyen L, Spitzhorn LS, Adjaye J
Stem cells international 2019;2019:3298432
Stem cells international 2019;2019:3298432
Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network.
Low JH, Li P, Chew EGY, Zhou B, Suzuki K, Zhang T, Lian MM, Liu M, Aizawa E, Rodriguez Esteban C, Yong KSM, Chen Q, Campistol JM, Fang M, Khor CC, Foo JN, Izpisua Belmonte JC, Xia Y
Cell stem cell 2019 Sep 5;25(3):373-387.e9
Cell stem cell 2019 Sep 5;25(3):373-387.e9
Molecular characterization of nephron progenitors and their early epithelial derivative structures in the nephrogenic zone of the canine fetal kidney.
Faraj R, Irizarry-Alfonzo A, Puri P
European journal of histochemistry : EJH 2019 Sep 23;63(3)
European journal of histochemistry : EJH 2019 Sep 23;63(3)
Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes.
Benedetti V, Lavecchia AM, Locatelli M, Brizi V, Corna D, Todeschini M, Novelli R, Benigni A, Zoja C, Remuzzi G, Xinaris C
JCI insight 2019 Sep 19;4(18)
JCI insight 2019 Sep 19;4(18)
Transcription factor Six2 induces a stem cell-like phenotype in renal cell carcinoma cells.
Cheng N, Li H, Han Y, Sun S
FEBS open bio 2019 Oct;9(10):1808-1816
FEBS open bio 2019 Oct;9(10):1808-1816
A Toolbox to Characterize Human Induced Pluripotent Stem Cell-Derived Kidney Cell Types and Organoids.
Vanslambrouck JM, Wilson SB, Tan KS, Soo JY, Scurr M, Spijker HS, Starks LT, Neilson A, Cui X, Jain S, Little MH, Howden SE
Journal of the American Society of Nephrology : JASN 2019 Oct;30(10):1811-1823
Journal of the American Society of Nephrology : JASN 2019 Oct;30(10):1811-1823
Morphogenesis of the kidney and lung requires branch-tip directed activity of the Adamts18 metalloprotease.
Rutledge EA, Parvez RK, Short KM, Smyth IM, McMahon AP
Developmental biology 2019 Oct 15;454(2):156-169
Developmental biology 2019 Oct 15;454(2):156-169
Tumor-suppressive activity of Hnf1β in Wilms' tumor.
Liu Y, Kanyomse Q, Xie Y
Bioscience, biotechnology, and biochemistry 2019 Nov;83(11):2008-2015
Bioscience, biotechnology, and biochemistry 2019 Nov;83(11):2008-2015
In utero exposure to maternal diabetes impairs nephron progenitor differentiation.
Cerqueira DM, Hemker SL, Bodnar AJ, Ortiz DM, Oladipupo FO, Mukherjee E, Gong Z, Appolonia C, Muzumdar R, Sims-Lucas S, Ho J
American journal of physiology. Renal physiology 2019 Nov 1;317(5):F1318-F1330
American journal of physiology. Renal physiology 2019 Nov 1;317(5):F1318-F1330
Crucial and Overlapping Roles of Six1 and Six2 in Craniofacial Development.
Liu Z, Li C, Xu J, Lan Y, Liu H, Li X, Maire P, Wang X, Jiang R
Journal of dental research 2019 May;98(5):572-579
Journal of dental research 2019 May;98(5):572-579
Disabling of nephrogenesis in porcine embryos via CRISPR/Cas9-mediated SIX1 and SIX4 gene targeting.
Wang J, Liu M, Zhao L, Li Y, Zhang M, Jin Y, Xiong Q, Liu X, Zhang L, Jiang H, Chen Q, Wang C, You Z, Yang H, Cao C, Dai Y, Li R
Xenotransplantation 2019 May;26(3):e12484
Xenotransplantation 2019 May;26(3):e12484
In vivo regeneration of interspecies chimeric kidneys using a nephron progenitor cell replacement system.
Fujimoto T, Yamanaka S, Tajiri S, Takamura T, Saito Y, Matsumoto K, Takase K, Fukunaga S, Okano HJ, Yokoo T
Scientific reports 2019 May 6;9(1):6965
Scientific reports 2019 May 6;9(1):6965
Anephrogenic phenotype induced by SALL1 gene knockout in pigs.
Watanabe M, Nakano K, Uchikura A, Matsunari H, Yashima S, Umeyama K, Takayanagi S, Sakuma T, Yamamoto T, Morita S, Horii T, Hatada I, Nishinakamura R, Nakauchi H, Nagashima H
Scientific reports 2019 May 29;9(1):8016
Scientific reports 2019 May 29;9(1):8016
Stromal prorenin receptor is critical for normal kidney development.
Yosypiv IV, Sequeira-Lopez MLS, Song R, De Goes Martini A
American journal of physiology. Regulatory, integrative and comparative physiology 2019 May 1;316(5):R640-R650
American journal of physiology. Regulatory, integrative and comparative physiology 2019 May 1;316(5):R640-R650
Loss of miR-17~92 results in dysregulation of Cftr in nephron progenitors.
Phua YL, Chen KH, Hemker SL, Marrone AK, Bodnar AJ, Liu X, Clugston A, Kostka D, Butterworth MB, Ho J
American journal of physiology. Renal physiology 2019 May 1;316(5):F993-F1005
American journal of physiology. Renal physiology 2019 May 1;316(5):F993-F1005
Tubuloids derived from human adult kidney and urine for personalized disease modeling.
Schutgens F, Rookmaaker MB, Margaritis T, Rios A, Ammerlaan C, Jansen J, Gijzen L, Vormann M, Vonk A, Viveen M, Yengej FY, Derakhshan S, de Winter-de Groot KM, Artegiani B, van Boxtel R, Cuppen E, Hendrickx APA, van den Heuvel-Eibrink MM, Heitzer E, Lanz H, Beekman J, Murk JL, Masereeuw R, Holstege F, Drost J, Verhaar MC, Clevers H
Nature biotechnology 2019 Mar;37(3):303-313
Nature biotechnology 2019 Mar;37(3):303-313
Platforms of in vivo genome editing with inducible Cas9 for advanced cancer modeling.
Jo N, Sogabe Y, Yamada Y, Ukai T, Kagawa H, Mitsunaga K, Woltjen K, Yamada Y
Cancer science 2019 Mar;110(3):926-938
Cancer science 2019 Mar;110(3):926-938
FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling.
Zhang H, Bagherie-Lachidan M, Badouel C, Enderle L, Peidis P, Bremner R, Kuure S, Jain S, McNeill H
Developmental cell 2019 Mar 25;48(6):780-792.e4
Developmental cell 2019 Mar 25;48(6):780-792.e4
Loss-of-function mutations in KIF14 cause severe microcephaly and kidney development defects in humans and zebrafish.
Reilly ML, Stokman MF, Magry V, Jeanpierre C, Alves M, Paydar M, Hellinga J, Delous M, Pouly D, Failler M, Martinovic J, Loeuillet L, Leroy B, Tantau J, Roume J, Gregory-Evans CY, Shan X, Filges I, Allingham JS, Kwok BH, Saunier S, Giles RH, Benmerah A
Human molecular genetics 2019 Mar 1;28(5):778-795
Human molecular genetics 2019 Mar 1;28(5):778-795
Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk.
Combes AN, Phipson B, Lawlor KT, Dorison A, Patrick R, Zappia L, Harvey RP, Oshlack A, Little MH
Development (Cambridge, England) 2019 Jun 12;146(12)
Development (Cambridge, England) 2019 Jun 12;146(12)
PPARG Negatively Modulates Six2 in Tumor Formation of Clear Cell Renal Cell Carcinoma.
Wu Y, Song T, Liu M, He Q, Chen L, Liu Y, Ni D, Liu J, Hu Y, Gu Y, Li Q, Zhou Q, Xie Y
DNA and cell biology 2019 Jul;38(7):700-707
DNA and cell biology 2019 Jul;38(7):700-707
Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation.
Cargill K, Hemker SL, Clugston A, Murali A, Mukherjee E, Liu J, Bushnell D, Bodnar AJ, Saifudeen Z, Ho J, Bates CM, Kostka D, Goetzman ES, Sims-Lucas S
Journal of the American Society of Nephrology : JASN 2019 Jul;30(7):1192-1205
Journal of the American Society of Nephrology : JASN 2019 Jul;30(7):1192-1205
DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation.
Wanner N, Vornweg J, Combes A, Wilson S, Plappert J, Rafflenbeul G, Puelles VG, Rahman RU, Liwinski T, Lindner S, Grahammer F, Kretz O, Wlodek ME, Romano T, Moritz KM, Boerries M, Busch H, Bonn S, Little MH, Bechtel-Walz W, Huber TB
Journal of the American Society of Nephrology : JASN 2019 Jan;30(1):63-78
Journal of the American Society of Nephrology : JASN 2019 Jan;30(1):63-78
Nephron progenitor commitment is a stochastic process influenced by cell migration.
Lawlor KT, Zappia L, Lefevre J, Park JS, Hamilton NA, Oshlack A, Little MH, Combes AN
eLife 2019 Jan 24;8
eLife 2019 Jan 24;8
Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis.
Yermalovich AV, Osborne JK, Sousa P, Han A, Kinney MA, Chen MJ, Robinton DA, Montie H, Pearson DS, Wilson SB, Combes AN, Little MH, Daley GQ
Nature communications 2019 Jan 11;10(1):168
Nature communications 2019 Jan 11;10(1):168
Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development.
Hochane M, van den Berg PR, Fan X, Bérenger-Currias N, Adegeest E, Bialecka M, Nieveen M, Menschaart M, Chuva de Sousa Lopes SM, Semrau S
PLoS biology 2019 Feb;17(2):e3000152
PLoS biology 2019 Feb;17(2):e3000152
Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats.
Goto T, Hara H, Sanbo M, Masaki H, Sato H, Yamaguchi T, Hochi S, Kobayashi T, Nakauchi H, Hirabayashi M
Nature communications 2019 Feb 5;10(1):451
Nature communications 2019 Feb 5;10(1):451
Reconstitution of the embryonic kidney identifies a donor cell contribution to the renal vasculature upon transplantation.
Murakami Y, Naganuma H, Tanigawa S, Fujimori T, Eto M, Nishinakamura R
Scientific reports 2019 Feb 4;9(1):1172
Scientific reports 2019 Feb 4;9(1):1172
Six2 is negatively correlated with prognosis and facilitates epithelial-mesenchymal transition via TGF-β/Smad signal pathway in hepatocellular carcinoma.
Wan ZH, Ma YH, Jiang TY, Lin YK, Shi YY, Tan YX, Dong LW, Wang HY
Hepatobiliary & pancreatic diseases international : HBPD INT 2019 Dec;18(6):525-531
Hepatobiliary & pancreatic diseases international : HBPD INT 2019 Dec;18(6):525-531
Forty-five patient-derived xenografts capture the clinical and biological heterogeneity of Wilms tumor.
Murphy AJ, Chen X, Pinto EM, Williams JS, Clay MR, Pounds SB, Cao X, Shi L, Lin T, Neale G, Morton CL, Woolard MA, Mulder HL, Gil HJ, Rehg JE, Billups CA, Harlow ML, Dome JS, Houghton PJ, Easton J, Zhang J, George RE, Zambetti GP, Davidoff AM
Nature communications 2019 Dec 20;10(1):5806
Nature communications 2019 Dec 20;10(1):5806
Molecular determinants of nephron vascular specialization in the kidney.
Barry DM, McMillan EA, Kunar B, Lis R, Zhang T, Lu T, Daniel E, Yokoyama M, Gomez-Salinero JM, Sureshbabu A, Cleaver O, Di Lorenzo A, Choi ME, Xiang J, Redmond D, Rabbany SY, Muthukumar T, Rafii S
Nature communications 2019 Dec 13;10(1):5705
Nature communications 2019 Dec 13;10(1):5705
A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB.
Liu Z, Mar KB, Hanners NW, Perelman SS, Kanchwala M, Xing C, Schoggins JW, Alto NM
Nature 2019 Apr;568(7751):249-253
Nature 2019 Apr;568(7751):249-253
DNMT1 in Six2 Progenitor Cells Is Essential for Transposable Element Silencing and Kidney Development.
Li SY, Park J, Guan Y, Chung K, Shrestha R, Palmer MB, Susztak K
Journal of the American Society of Nephrology : JASN 2019 Apr;30(4):594-609
Journal of the American Society of Nephrology : JASN 2019 Apr;30(4):594-609
Reporter-based fate mapping in human kidney organoids confirms nephron lineage relationships and reveals synchronous nephron formation.
Howden SE, Vanslambrouck JM, Wilson SB, Tan KS, Little MH
EMBO reports 2019 Apr;20(4)
EMBO reports 2019 Apr;20(4)
Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells.
Garreta E, Prado P, Tarantino C, Oria R, Fanlo L, Martí E, Zalvidea D, Trepat X, Roca-Cusachs P, Gavaldà-Navarro A, Cozzuto L, Campistol JM, Izpisúa Belmonte JC, Hurtado Del Pozo C, Montserrat N
Nature materials 2019 Apr;18(4):397-405
Nature materials 2019 Apr;18(4):397-405
Ex vivo live cell tracking in kidney organoids using light sheet fluorescence microscopy.
Held M, Santeramo I, Wilm B, Murray P, Lévy R
PloS one 2018;13(7):e0199918
PloS one 2018;13(7):e0199918
Gulo regulates the proliferation, apoptosis and mesenchymal-to-epithelial transformation of metanephric mesenchyme cells via inhibiting Six2.
He Q, Chen L, Liu Y, Wu Y, Ni D, Liu J, Hu Y, Gu Y, Xie Y, Zhou Q, Li Q
Biochemical and biophysical research communications 2018 Oct 12;504(4):885-891
Biochemical and biophysical research communications 2018 Oct 12;504(4):885-891
Maternal malnourishment induced upregulation of fetuin-B blunts nephrogenesis in the low birth weight neonate.
Rabadi MM, Abdulmahdi W, Nesi L, Jules E, Marghani Y, Sheinin E, Tilzer J, Gupta S, Chen S, Cassimatis ND, Lipphardt M, Kozlowski PB, Ratliff BB
Developmental biology 2018 Nov 1;443(1):78-91
Developmental biology 2018 Nov 1;443(1):78-91
Sox11 gene disruption causes congenital anomalies of the kidney and urinary tract (CAKUT).
Neirijnck Y, Reginensi A, Renkema KY, Massa F, Kozlov VM, Dhib H, Bongers EMHF, Feitz WF, van Eerde AM, Lefebvre V, Knoers NVAM, Tabatabaei M, Schulz H, McNeill H, Schaefer F, Wegner M, Sock E, Schedl A
Kidney international 2018 May;93(5):1142-1153
Kidney international 2018 May;93(5):1142-1153
Histone deacetylases 1 and 2 regulate the transcriptional programs of nephron progenitors and renal vesicles.
Liu H, Chen S, Yao X, Li Y, Chen CH, Liu J, Saifudeen Z, El-Dahr SS
Development (Cambridge, England) 2018 May 18;145(10)
Development (Cambridge, England) 2018 May 18;145(10)
Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number.
Combes AN, Wilson S, Phipson B, Binnie BB, Ju A, Lawlor KT, Cebrian C, Walton SL, Smyth IM, Moritz KM, Kopan R, Oshlack A, Little MH
Kidney international 2018 Mar;93(3):589-598
Kidney international 2018 Mar;93(3):589-598
Reduced Abd-B Hox function during kidney development results in lineage infidelity.
Magella B, Mahoney R, Adam M, Potter SS
Developmental biology 2018 Jun 15;438(2):84-93
Developmental biology 2018 Jun 15;438(2):84-93
Hedgehog-GLI signaling in Foxd1-positive stromal cells promotes murine nephrogenesis via TGFβ signaling.
Rowan CJ, Li W, Martirosyan H, Erwood S, Hu D, Kim YK, Sheybani-Deloui S, Mulder J, Blake J, Chen L, Rosenblum ND
Development (Cambridge, England) 2018 Jul 9;145(13)
Development (Cambridge, England) 2018 Jul 9;145(13)
Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration.
Short KM, Combes AN, Lisnyak V, Lefevre JG, Jones LK, Little MH, Hamilton NA, Smyth IM
eLife 2018 Jul 31;7
eLife 2018 Jul 31;7
An optimal serum-free defined condition for in vitro culture of kidney organoids.
Nishikawa M, Kimura H, Yanagawa N, Hamon M, Hauser P, Zhao L, Jo OD, Yanagawa N
Biochemical and biophysical research communications 2018 Jul 2;501(4):996-1002
Biochemical and biophysical research communications 2018 Jul 2;501(4):996-1002
Centrosome amplification disrupts renal development and causes cystogenesis.
Dionne LK, Shim K, Hoshi M, Cheng T, Wang J, Marthiens V, Knoten A, Basto R, Jain S, Mahjoub MR
The Journal of cell biology 2018 Jul 2;217(7):2485-2501
The Journal of cell biology 2018 Jul 2;217(7):2485-2501
EED, a member of the polycomb group, is required for nephron differentiation and the maintenance of nephron progenitor cells.
Zhang L, Ettou S, Khalid M, Taglienti M, Jain D, Jung YL, Seager C, Liu Y, Ng KH, Park PJ, Kreidberg JA
Development (Cambridge, England) 2018 Jul 18;145(14)
Development (Cambridge, England) 2018 Jul 18;145(14)
Ectopic Phosphorylated Creb Marks Dedifferentiated Proximal Tubules in Cystic Kidney Disease.
Puri P, Schaefer CM, Bushnell D, Taglienti ME, Kreidberg JA, Yoder BK, Bates CM
The American journal of pathology 2018 Jan;188(1):84-94
The American journal of pathology 2018 Jan;188(1):84-94
Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies.
O'Brien LL, Guo Q, Bahrami-Samani E, Park JS, Hasso SM, Lee YJ, Fang A, Kim AD, Guo J, Hong TM, Peterson KA, Lozanoff S, Raviram R, Ren B, Fogelgren B, Smith AD, Valouev A, McMahon AP
PLoS genetics 2018 Jan;14(1):e1007181
PLoS genetics 2018 Jan;14(1):e1007181
Optimal route of diphtheria toxin administration to eliminate native nephron progenitor cells in vivo for kidney regeneration.
Fukunaga S, Yamanaka S, Fujimoto T, Tajiri S, Uchiyama T, Matsumoto K, Ito T, Tanabe K, Yokoo T
Biochemical and biophysical research communications 2018 Feb 19;496(4):1176-1182
Biochemical and biophysical research communications 2018 Feb 19;496(4):1176-1182
Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment.
O'Brien LL, Combes AN, Short KM, Lindström NO, Whitney PH, Cullen-McEwen LA, Ju A, Abdelhalim A, Michos O, Bertram JF, Smyth IM, Little MH, McMahon AP
eLife 2018 Dec 5;7
eLife 2018 Dec 5;7
Six2 is negatively correlated with good prognosis and decreases 5-FU sensitivity via suppressing E-cadherin expression in hepatocellular carcinoma cells.
Li JW, Huang CZ, Li JH, Yuan JH, Chen QH, Zhang WF, Xu ZS, Liu YP, Li Y, Zhan MX, Lu LG
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Aug;104:204-210
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Aug;104:204-210
Six2 Plays an Intrinsic Role in Regulating Proliferation of Mesenchymal Cells in the Developing Palate.
Okello DO, Iyyanar PPR, Kulyk WM, Smith TM, Lozanoff S, Ji S, Nazarali AJ
Frontiers in physiology 2017;8:955
Frontiers in physiology 2017;8:955
Effect of Hypoxia on the Differentiation and the Self-Renewal of Metanephrogenic Mesenchymal Stem Cells.
Liu S, Song N, He J, Yu X, Guo J, Jiao X, Ding X, Teng J
Stem cells international 2017;2017:7168687
Stem cells international 2017;2017:7168687
The developmental programme for genesis of the entire kidney is recapitulated in Wilms tumour.
Fukuzawa R, Anaka MR, Morison IM, Reeve AE
PloS one 2017;12(10):e0186333
PloS one 2017;12(10):e0186333
Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium.
Yucer N, Holzapfel M, Jenkins Vogel T, Lenaeus L, Ornelas L, Laury A, Sareen D, Barrett R, Karlan BY, Svendsen CN
Scientific reports 2017 Sep 6;7(1):10741
Scientific reports 2017 Sep 6;7(1):10741
A Novel Method for Isolation of Pluripotent Stem Cells from Human Umbilical Cord Blood.
Monti M, Imberti B, Bianchi N, Pezzotta A, Morigi M, Del Fante C, Redi CA, Perotti C
Stem cells and development 2017 Sep 1;26(17):1258-1269
Stem cells and development 2017 Sep 1;26(17):1258-1269
LIM kinase function and renal growth: Potential role for LIM kinases in fetal programming of kidney development.
Sparrow AJ, Sweetman D, Welham SJM
Life sciences 2017 Oct 1;186:17-24
Life sciences 2017 Oct 1;186:17-24
Regulation of Nephron Progenitor Cell Self-Renewal by Intermediary Metabolism.
Liu J, Edgington-Giordano F, Dugas C, Abrams A, Katakam P, Satou R, Saifudeen Z
Journal of the American Society of Nephrology : JASN 2017 Nov;28(11):3323-3335
Journal of the American Society of Nephrology : JASN 2017 Nov;28(11):3323-3335
Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system.
Yamanaka S, Tajiri S, Fujimoto T, Matsumoto K, Fukunaga S, Kim BS, Okano HJ, Yokoo T
Nature communications 2017 Nov 23;8(1):1719
Nature communications 2017 Nov 23;8(1):1719
Mutations in GREB1L Cause Bilateral Kidney Agenesis in Humans and Mice.
De Tomasi L, David P, Humbert C, Silbermann F, Arrondel C, Tores F, Fouquet S, Desgrange A, Niel O, Bole-Feysot C, Nitschké P, Roume J, Cordier MP, Pietrement C, Isidor B, Khau Van Kien P, Gonzales M, Saint-Frison MH, Martinovic J, Novo R, Piard J, Cabrol C, Verma IC, Puri R, Journel H, Aziza J, Gavard L, Said-Menthon MH, Heidet L, Saunier S, Jeanpierre C
American journal of human genetics 2017 Nov 2;101(5):803-814
American journal of human genetics 2017 Nov 2;101(5):803-814
Myc cooperates with β-catenin to drive gene expression in nephron progenitor cells.
Pan X, Karner CM, Carroll TJ
Development (Cambridge, England) 2017 Nov 15;144(22):4173-4182
Development (Cambridge, England) 2017 Nov 15;144(22):4173-4182
Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.
Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A
Developmental cell 2017 May 22;41(4):349-365.e3
Developmental cell 2017 May 22;41(4):349-365.e3
Lats1/2 Regulate Yap/Taz to Control Nephron Progenitor Epithelialization and Inhibit Myofibroblast Formation.
McNeill H, Reginensi A
Journal of the American Society of Nephrology : JASN 2017 Mar;28(3):852-861
Journal of the American Society of Nephrology : JASN 2017 Mar;28(3):852-861
Tridimensional Visualization and Analysis of Early Human Development.
Belle M, Godefroy D, Couly G, Malone SA, Collier F, Giacobini P, Chédotal A
Cell 2017 Mar 23;169(1):161-173.e12
Cell 2017 Mar 23;169(1):161-173.e12
Novel fixed z-direction (FiZD) kidney primordia and an organoid culture system for time-lapse confocal imaging.
Saarela U, Akram SU, Desgrange A, Rak-Raszewska A, Shan J, Cereghini S, Ronkainen VP, Heikkilä J, Skovorodkin I, Vainio SJ
Development (Cambridge, England) 2017 Mar 15;144(6):1113-1117
Development (Cambridge, England) 2017 Mar 15;144(6):1113-1117
Self-organisation after embryonic kidney dissociation is driven via selective adhesion of ureteric epithelial cells.
Lefevre JG, Chiu HS, Combes AN, Vanslambrouck JM, Ju A, Hamilton NA, Little MH
Development (Cambridge, England) 2017 Mar 15;144(6):1087-1096
Development (Cambridge, England) 2017 Mar 15;144(6):1087-1096
Cycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney.
Munro DAD, Hohenstein P, Davies JA
Scientific reports 2017 Jun 12;7(1):3273
Scientific reports 2017 Jun 12;7(1):3273
Evidence of In Vitro Preservation of Human Nephrogenesis at the Single-Cell Level.
Pode-Shakked N, Gershon R, Tam G, Omer D, Gnatek Y, Kanter I, Oriel S, Katz G, Harari-Steinberg O, Kalisky T, Dekel B
Stem cell reports 2017 Jul 11;9(1):279-291
Stem cell reports 2017 Jul 11;9(1):279-291
Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells.
Morizane R, Bonventre JV
Nature protocols 2017 Jan;12(1):195-207
Nature protocols 2017 Jan;12(1):195-207
Repair after nephron ablation reveals limitations of neonatal neonephrogenesis.
Tögel F, Valerius MT, Freedman BS, Iatrino R, Grinstein M, Bonventre JV
JCI insight 2017 Jan 26;2(2):e88848
JCI insight 2017 Jan 26;2(2):e88848
Temporally Distinct Six2-Positive Second Heart Field Progenitors Regulate Mammalian Heart Development and Disease.
Zhou Z, Wang J, Guo C, Chang W, Zhuang J, Zhu P, Li X
Cell reports 2017 Jan 24;18(4):1019-1032
Cell reports 2017 Jan 24;18(4):1019-1032
In Vitro Propagation and Branching Morphogenesis from Single Ureteric Bud Cells.
Yuri S, Nishikawa M, Yanagawa N, Jo OD, Yanagawa N
Stem cell reports 2017 Feb 14;8(2):401-416
Stem cell reports 2017 Feb 14;8(2):401-416
Derivation and characterization of integration-free iPSC line ISRM-UM51 derived from SIX2-positive renal cells isolated from urine of an African male expressing the CYP2D6 *4/*17 variant which confers intermediate drug metabolizing activity.
Bohndorf M, Ncube A, Spitzhorn LS, Enczmann J, Wruck W, Adjaye J
Stem cell research 2017 Dec;25:18-21
Stem cell research 2017 Dec;25:18-21
Refuting the hypothesis that semaphorin-3f/neuropilin-2 exclude blood vessels from the cap mesenchyme in the developing kidney.
Munro DAD, Hohenstein P, Coate TM, Davies JA
Developmental dynamics : an official publication of the American Association of Anatomists 2017 Dec;246(12):1047-1056
Developmental dynamics : an official publication of the American Association of Anatomists 2017 Dec;246(12):1047-1056
Higher-Order Kidney Organogenesis from Pluripotent Stem Cells.
Taguchi A, Nishinakamura R
Cell stem cell 2017 Dec 7;21(6):730-746.e6
Cell stem cell 2017 Dec 7;21(6):730-746.e6
In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation.
Liao HK, Hatanaka F, Araoka T, Reddy P, Wu MZ, Sui Y, Yamauchi T, Sakurai M, O'Keefe DD, Núñez-Delicado E, Guillen P, Campistol JM, Wu CJ, Lu LF, Esteban CR, Izpisua Belmonte JC
Cell 2017 Dec 14;171(7):1495-1507.e15
Cell 2017 Dec 14;171(7):1495-1507.e15
Low birth weight is associated with impaired murine kidney development and function.
Barnett C, Nnoli O, Abdulmahdi W, Nesi L, Shen M, Zullo JA, Payne DL, Azar T, Dwivedi P, Syed K, Gromis J, Lipphardt M, Jules E, Maranda EL, Patel A, Rabadi MM, Ratliff BB
Pediatric research 2017 Aug;82(2):340-348
Pediatric research 2017 Aug;82(2):340-348
BMP7 dose-dependently stimulates proliferation and cadherin-11 expression via ERK and p38 in a murine metanephric mesenchymal cell line.
Awazu M, Nagata M, Hida M
Physiological reports 2017 Aug;5(16)
Physiological reports 2017 Aug;5(16)
Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development.
Cerqueira DM, Bodnar AJ, Phua YL, Freer R, Hemker SL, Walensky LD, Hukriede NA, Ho J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Aug;31(8):3540-3554
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Aug;31(8):3540-3554
Acellular Mouse Kidney ECM can be Used as a Three-Dimensional Substrate to Test the Differentiation Potential of Embryonic Stem Cell Derived Renal Progenitors.
Sambi M, Chow T, Whiteley J, Li M, Chua S, Raileanu V, Rogers IM
Stem cell reviews and reports 2017 Aug;13(4):513-531
Stem cell reviews and reports 2017 Aug;13(4):513-531
TβRII Regulates the Proliferation of Metanephric Mesenchyme Cells through Six2 In Vitro.
Mao Z, Lyu Z, Huang L, Zhou Q, Weng Y
International journal of molecular sciences 2017 Apr 18;18(4)
International journal of molecular sciences 2017 Apr 18;18(4)
Osr1 Interacts Synergistically with Wt1 to Regulate Kidney Organogenesis.
Xu J, Liu H, Chai OH, Lan Y, Jiang R
PloS one 2016;11(7):e0159597
PloS one 2016;11(7):e0159597
Characterisation of Cultured Mesothelial Cells Derived from the Murine Adult Omentum.
Dauleh S, Santeramo I, Fielding C, Ward K, Herrmann A, Murray P, Wilm B
PloS one 2016;11(7):e0158997
PloS one 2016;11(7):e0158997
Postembryonic Nephrogenesis and Persistence of Six2-Expressing Nephron Progenitor Cells in the Reptilian Kidney.
Camarata T, Howard A, Elsey RM, Raza S, O'Connor A, Beatty B, Conrad J, Solounias N, Chow P, Mukta S, Vasilyev A
PloS one 2016;11(5):e0153422
PloS one 2016;11(5):e0153422
Six2 Is a Coordinator of LiCl-Induced Cell Proliferation and Apoptosis.
Liu J, Ju P, Zhou Y, Zhao Y, Xie Y, Long Y, Gu Y, Ni D, Lyv Z, Mao Z, Hao J, Li Y, Wan Q, Kanyomse Q, Liu Y, Xiang Y, Wang R, Chen X, Zhang J, Liu X, Zhao H, Zhou Q, Li G
International journal of molecular sciences 2016 Sep 8;17(9)
International journal of molecular sciences 2016 Sep 8;17(9)
Cap mesenchyme cell swarming during kidney development is influenced by attraction, repulsion, and adhesion to the ureteric tip.
Combes AN, Lefevre JG, Wilson S, Hamilton NA, Little MH
Developmental biology 2016 Oct 15;418(2):297-306
Developmental biology 2016 Oct 15;418(2):297-306
Notch signaling promotes nephrogenesis by downregulating Six2.
Chung E, Deacon P, Marable S, Shin J, Park JS
Development (Cambridge, England) 2016 Nov 1;143(21):3907-3913
Development (Cambridge, England) 2016 Nov 1;143(21):3907-3913
Preserved Nephrogenesis Following Partial Nephrectomy in Early Neonates.
Kirita Y, Kami D, Ishida R, Adachi T, Tamagaki K, Matoba S, Kusaba T, Gojo S
Scientific reports 2016 May 31;6:26792
Scientific reports 2016 May 31;6:26792
Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.
Arda HE, Li L, Tsai J, Torre EA, Rosli Y, Peiris H, Spitale RC, Dai C, Gu X, Qu K, Wang P, Wang J, Grompe M, Scharfmann R, Snyder MS, Bottino R, Powers AC, Chang HY, Kim SK
Cell metabolism 2016 May 10;23(5):909-20
Cell metabolism 2016 May 10;23(5):909-20
Prorenin receptor is critical for nephron progenitors.
Song R, Preston G, Kidd L, Bushnell D, Sims-Lucas S, Bates CM, Yosypiv IV
Developmental biology 2016 Jan 15;409(2):382-91
Developmental biology 2016 Jan 15;409(2):382-91
Nephron Progenitor But Not Stromal Progenitor Cells Give Rise to Wilms Tumors in Mouse Models with β-Catenin Activation or Wt1 Ablation and Igf2 Upregulation.
Huang L, Mokkapati S, Hu Q, Ruteshouser EC, Hicks MJ, Huff V
Neoplasia (New York, N.Y.) 2016 Feb;18(2):71-81
Neoplasia (New York, N.Y.) 2016 Feb;18(2):71-81
Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor.
Blake J, Hu D, Cain JE, Rosenblum ND
Human molecular genetics 2016 Feb 1;25(3):437-47
Human molecular genetics 2016 Feb 1;25(3):437-47
Zeb1 Is a Potential Regulator of Six2 in the Proliferation, Apoptosis and Migration of Metanephric Mesenchyme Cells.
Gu Y, Zhao Y, Zhou Y, Xie Y, Ju P, Long Y, Liu J, Ni D, Cao F, Lyu Z, Mao Z, Hao J, Li Y, Wan Q, Kanyomse Q, Liu Y, Ren D, Ning Y, Li X, Zhou Q, Li B
International journal of molecular sciences 2016 Aug 6;17(8)
International journal of molecular sciences 2016 Aug 6;17(8)
A critical role for NF2 and the Hippo pathway in branching morphogenesis.
Reginensi A, Enderle L, Gregorieff A, Johnson RL, Wrana JL, McNeill H
Nature communications 2016 Aug 2;7:12309
Nature communications 2016 Aug 2;7:12309
Selective In Vitro Propagation of Nephron Progenitors Derived from Embryos and Pluripotent Stem Cells.
Tanigawa S, Taguchi A, Sharma N, Perantoni AO, Nishinakamura R
Cell reports 2016 Apr 26;15(4):801-813
Cell reports 2016 Apr 26;15(4):801-813
Maintenance of Mouse Nephron Progenitor Cells in Aggregates with Gamma-Secretase Inhibitor.
Yuri S, Nishikawa M, Yanagawa N, Jo OD, Yanagawa N
PloS one 2015;10(6):e0129242
PloS one 2015;10(6):e0129242
Stromally expressed β-catenin modulates Wnt9b signaling in the ureteric epithelium.
Boivin FJ, Sarin S, Lim J, Javidan A, Svajger B, Khalili H, Bridgewater D
PloS one 2015;10(3):e0120347
PloS one 2015;10(3):e0120347
Natural Scaffolds for Renal Differentiation of Human Embryonic Stem Cells for Kidney Tissue Engineering.
Batchelder CA, Martinez ML, Tarantal AF
PloS one 2015;10(12):e0143849
PloS one 2015;10(12):e0143849
Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival.
Phua YL, Chu JY, Marrone AK, Bodnar AJ, Sims-Lucas S, Ho J
Physiological reports 2015 Oct;3(10)
Physiological reports 2015 Oct;3(10)
Sall1 in renal stromal progenitors non-cell autonomously restricts the excessive expansion of nephron progenitors.
Ohmori T, Tanigawa S, Kaku Y, Fujimura S, Nishinakamura R
Scientific reports 2015 Oct 29;5:15676
Scientific reports 2015 Oct 29;5:15676
Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis.
Takasato M, Er PX, Chiu HS, Maier B, Baillie GJ, Ferguson C, Parton RG, Wolvetang EJ, Roost MS, Chuva de Sousa Lopes SM, Little MH
Nature 2015 Oct 22;526(7574):564-8
Nature 2015 Oct 22;526(7574):564-8
Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan.
Chen S, Brunskill EW, Potter SS, Dexheimer PJ, Salomonis N, Aronow BJ, Hong CI, Zhang T, Kopan R
Developmental cell 2015 Oct 12;35(1):49-62
Developmental cell 2015 Oct 12;35(1):49-62
Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons.
Recuenco MC, Ohmori T, Tanigawa S, Taguchi A, Fujimura S, Conti MA, Wei Q, Kiyonari H, Abe T, Adelstein RS, Nishinakamura R
Journal of the American Society of Nephrology : JASN 2015 May;26(5):1081-91
Journal of the American Society of Nephrology : JASN 2015 May;26(5):1081-91
Single adult kidney stem/progenitor cells reconstitute three-dimensional nephron structures in vitro.
Kitamura S, Sakurai H, Makino H
Stem cells (Dayton, Ohio) 2015 Mar;33(3):774-84
Stem cells (Dayton, Ohio) 2015 Mar;33(3):774-84
A Cre-inducible fluorescent reporter for observing apical membrane dynamics.
Pan X, Schnell U, Karner CM, Small EV, Carroll TJ
Genesis (New York, N.Y. : 2000) 2015 Mar-Apr;53(3-4):285-93
Genesis (New York, N.Y. : 2000) 2015 Mar-Apr;53(3-4):285-93
Renal progenitors derived from human iPSCs engraft and restore function in a mouse model of acute kidney injury.
Imberti B, Tomasoni S, Ciampi O, Pezzotta A, Derosas M, Xinaris C, Rizzo P, Papadimou E, Novelli R, Benigni A, Remuzzi G, Morigi M
Scientific reports 2015 Mar 6;5:8826
Scientific reports 2015 Mar 6;5:8826
A synthetic niche for nephron progenitor cells.
Brown AC, Muthukrishnan SD, Oxburgh L
Developmental cell 2015 Jul 27;34(2):229-41
Developmental cell 2015 Jul 27;34(2):229-41
Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development.
Raines AM, Magella B, Adam M, Potter SS
BMC developmental biology 2015 Jul 19;15:28
BMC developmental biology 2015 Jul 19;15:28
Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells.
Muthukrishnan SD, Yang X, Friesel R, Oxburgh L
Nature communications 2015 Dec 4;6:10027
Nature communications 2015 Dec 4;6:10027
Cdc42 regulates epithelial cell polarity and cytoskeletal function during kidney tubule development.
Elias BC, Das A, Parekh DV, Mernaugh G, Adams R, Yang Z, Brakebusch C, Pozzi A, Marciano DK, Carroll TJ, Zent R
Journal of cell science 2015 Dec 1;128(23):4293-305
Journal of cell science 2015 Dec 1;128(23):4293-305
A developmentally plastic adult mouse kidney cell line spontaneously generates multiple adult kidney structures.
Webb CF, Ratliff ML, Powell R, Wirsig-Wiechmann CR, Lakiza O, Obara T
Biochemical and biophysical research communications 2015 Aug 7;463(4):1334-1340
Biochemical and biophysical research communications 2015 Aug 7;463(4):1334-1340
Fat4/Dchs1 signaling between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching.
Mao Y, Francis-West P, Irvine KD
Development (Cambridge, England) 2015 Aug 1;142(15):2574-85
Development (Cambridge, England) 2015 Aug 1;142(15):2574-85
Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool.
Bagherie-Lachidan M, Reginensi A, Pan Q, Zaveri HP, Scott DA, Blencowe BJ, Helmbacher F, McNeill H
Development (Cambridge, England) 2015 Aug 1;142(15):2564-73
Development (Cambridge, England) 2015 Aug 1;142(15):2564-73
Fibroblast growth factor receptor-Frs2α signaling is critical for nephron progenitors.
Di Giovanni V, Walker KA, Bushnell D, Schaefer C, Sims-Lucas S, Puri P, Bates CM
Developmental biology 2015 Apr 1;400(1):82-93
Developmental biology 2015 Apr 1;400(1):82-93
WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals.
Kann M, Bae E, Lenz MO, Li L, Trannguyen B, Schumacher VA, Taglienti ME, Bordeianou L, Hartwig S, Rinschen MM, Schermer B, Benzing T, Fan CM, Kreidberg JA
Development (Cambridge, England) 2015 Apr 1;142(7):1254-66
Development (Cambridge, England) 2015 Apr 1;142(7):1254-66
Ablation of the renal stroma defines its critical role in nephron progenitor and vasculature patterning.
Hum S, Rymer C, Schaefer C, Bushnell D, Sims-Lucas S
PloS one 2014;9(2):e88400
PloS one 2014;9(2):e88400
miR181c promotes apoptosis and suppresses proliferation of metanephric mesenchyme cells by targeting Six2 in vitro.
Lv X, Mao Z, Lyu Z, Zhang P, Zhan A, Wang J, Yang H, Li M, Wang H, Wan Q, Wei H, Wang M, Wang N, Li X, Liu Y, Zhao H, Zhou Q
Cell biochemistry and function 2014 Oct;32(7):571-9
Cell biochemistry and function 2014 Oct;32(7):571-9
The generation of kidney organoids by differentiation of human pluripotent cells to ureteric bud progenitor-like cells.
Xia Y, Sancho-Martinez I, Nivet E, Rodriguez Esteban C, Campistol JM, Izpisua Belmonte JC
Nature protocols 2014 Nov;9(11):2693-704
Nature protocols 2014 Nov;9(11):2693-704
Sall1 maintains nephron progenitors and nascent nephrons by acting as both an activator and a repressor.
Kanda S, Tanigawa S, Ohmori T, Taguchi A, Kudo K, Suzuki Y, Sato Y, Hino S, Sander M, Perantoni AO, Sugano S, Nakao M, Nishinakamura R
Journal of the American Society of Nephrology : JASN 2014 Nov;25(11):2584-95
Journal of the American Society of Nephrology : JASN 2014 Nov;25(11):2584-95
Down-regulated Six2 by knockdown of neurofibromin results in apoptosis of metanephric mesenchyme cells in vitro.
Zhou P, Chen T, Fang Y, Wang H, Li M, Ma P, He L, Li Q, Liu T, Yang X, Nie F, Wang X, Yuan Y, Zhou L, Peng R, Liu Z, Zhou Q
Molecular and cellular biochemistry 2014 May;390(1-2):205-13
Molecular and cellular biochemistry 2014 May;390(1-2):205-13
β-Catenin overexpression in the metanephric mesenchyme leads to renal dysplasia genesis via cell-autonomous and non-cell-autonomous mechanisms.
Sarin S, Boivin F, Li A, Lim J, Svajger B, Rosenblum ND, Bridgewater D
The American journal of pathology 2014 May;184(5):1395-410
The American journal of pathology 2014 May;184(5):1395-410
Lin28 sustains early renal progenitors and induces Wilms tumor.
Urbach A, Yermalovich A, Zhang J, Spina CS, Zhu H, Perez-Atayde AR, Shukrun R, Charlton J, Sebire N, Mifsud W, Dekel B, Pritchard-Jones K, Daley GQ
Genes & development 2014 May 1;28(9):971-82
Genes & development 2014 May 1;28(9):971-82
Mdm2 is required for maintenance of the nephrogenic niche.
Hilliard SA, Yao X, El-Dahr SS
Developmental biology 2014 Mar 1;387(1):1-14
Developmental biology 2014 Mar 1;387(1):1-14
Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers.
Lam AQ, Freedman BS, Morizane R, Lerou PH, Valerius MT, Bonventre JV
Journal of the American Society of Nephrology : JASN 2014 Jun;25(6):1211-25
Journal of the American Society of Nephrology : JASN 2014 Jun;25(6):1211-25
Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney.
Takasato M, Er PX, Becroft M, Vanslambrouck JM, Stanley EG, Elefanty AG, Little MH
Nature cell biology 2014 Jan;16(1):118-26
Nature cell biology 2014 Jan;16(1):118-26
Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells.
Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, Sasaki H, Nishinakamura R
Cell stem cell 2014 Jan 2;14(1):53-67
Cell stem cell 2014 Jan 2;14(1):53-67
In situ histone landscape of nephrogenesis.
McLaughlin N, Wang F, Saifudeen Z, El-Dahr SS
Epigenetics 2014 Feb;9(2):222-35
Epigenetics 2014 Feb;9(2):222-35
Aberrant activation, nuclear localization, and phosphorylation of Yes-associated protein-1 in the embryonic kidney and Wilms tumor.
Murphy AJ, Pierce J, de Caestecker C, Libes J, Neblett D, de Caestecker M, Perantoni AO, Tanigawa S, Anderson JR, Dome JS, Das A, Carroll TJ, Lovvorn HN 3rd
Pediatric blood & cancer 2014 Feb;61(2):198-205
Pediatric blood & cancer 2014 Feb;61(2):198-205
An integrated pipeline for the multidimensional analysis of branching morphogenesis.
Combes AN, Short KM, Lefevre J, Hamilton NA, Little MH, Smyth IM
Nature protocols 2014 Dec;9(12):2859-79
Nature protocols 2014 Dec;9(12):2859-79
Identification and characterization of retinoic acid-responsive genes in mouse kidney development.
Takayama M, Miyatake K, Nishida E
Genes to cells : devoted to molecular & cellular mechanisms 2014 Aug;19(8):637-49
Genes to cells : devoted to molecular & cellular mechanisms 2014 Aug;19(8):637-49
Single cell dissection of early kidney development: multilineage priming.
Brunskill EW, Park JS, Chung E, Chen F, Magella B, Potter SS
Development (Cambridge, England) 2014 Aug;141(15):3093-101
Development (Cambridge, England) 2014 Aug;141(15):3093-101
Renal blood flow and oxygenation drive nephron progenitor differentiation.
Rymer C, Paredes J, Halt K, Schaefer C, Wiersch J, Zhang G, Potoka D, Vainio S, Gittes GK, Bates CM, Sims-Lucas S
American journal of physiology. Renal physiology 2014 Aug 1;307(3):F337-45
American journal of physiology. Renal physiology 2014 Aug 1;307(3):F337-45
Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis.
Xu J, Liu H, Park JS, Lan Y, Jiang R
Development (Cambridge, England) 2014 Apr;141(7):1442-52
Development (Cambridge, England) 2014 Apr;141(7):1442-52
Global quantification of tissue dynamics in the developing mouse kidney.
Short KM, Combes AN, Lefevre J, Ju AL, Georgas KM, Lamberton T, Cairncross O, Rumballe BA, McMahon AP, Hamilton NA, Smyth IM, Little MH
Developmental cell 2014 Apr 28;29(2):188-202
Developmental cell 2014 Apr 28;29(2):188-202
The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment.
Cebrian C, Asai N, D'Agati V, Costantini F
Cell reports 2014 Apr 10;7(1):127-37
Cell reports 2014 Apr 10;7(1):127-37
Dicer function is required in the metanephric mesenchyme for early kidney development.
Chu JY, Sims-Lucas S, Bushnell DS, Bodnar AJ, Kreidberg JA, Ho J
American journal of physiology. Renal physiology 2014 Apr 1;306(7):F764-72
American journal of physiology. Renal physiology 2014 Apr 1;306(7):F764-72
Sall4 Is Transiently Expressed in the Caudal Wolffian Duct and the Ureteric Bud, but Dispensable for Kidney Development.
Toyoda D, Taguchi A, Chiga M, Ohmori T, Nishinakamura R
PloS one 2013;8(6):e68508
PloS one 2013;8(6):e68508
Endothelial Progenitors Exist within the Kidney and Lung Mesenchyme.
Sims-Lucas S, Schaefer C, Bushnell D, Ho J, Logar A, Prochownik E, Gittes G, Bates CM
PloS one 2013;8(6):e65993
PloS one 2013;8(6):e65993
Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation.
Das A, Tanigawa S, Karner CM, Xin M, Lum L, Chen C, Olson EN, Perantoni AO, Carroll TJ
Nature cell biology 2013 Sep;15(9):1035-44
Nature cell biology 2013 Sep;15(9):1035-44
Stage specific requirement of Gfrα1 in the ureteric epithelium during kidney development.
Keefe Davis T, Hoshi M, Jain S
Mechanisms of development 2013 Sep-Oct;130(9-10):506-18
Mechanisms of development 2013 Sep-Oct;130(9-10):506-18
MiR-181b targets Six2 and inhibits the proliferation of metanephric mesenchymal cells in vitro.
lyu Z, Mao Z, Wang H, Fang Y, Chen T, Wan Q, Wang M, Wang N, Xiao J, Wei H, Li X, Liu Y, Zhou Q
Biochemical and biophysical research communications 2013 Nov 1;440(4):495-501
Biochemical and biophysical research communications 2013 Nov 1;440(4):495-501
Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development.
Reginensi A, Scott RP, Gregorieff A, Bagherie-Lachidan M, Chung C, Lim DS, Pawson T, Wrana J, McNeill H
PLoS genetics 2013 Mar;9(3):e1003380
PLoS genetics 2013 Mar;9(3):e1003380
Scaffolding proteins DLG1 and CASK cooperate to maintain the nephron progenitor population during kidney development.
Ahn SY, Kim Y, Kim ST, Swat W, Miner JH
Journal of the American Society of Nephrology : JASN 2013 Jun;24(7):1127-38
Journal of the American Society of Nephrology : JASN 2013 Jun;24(7):1127-38
Directed differentiation of human pluripotent cells to ureteric bud kidney progenitor-like cells.
Xia Y, Nivet E, Sancho-Martinez I, Gallegos T, Suzuki K, Okamura D, Wu MZ, Dubova I, Esteban CR, Montserrat N, Campistol JM, Izpisua Belmonte JC
Nature cell biology 2013 Dec;15(12):1507-15
Nature cell biology 2013 Dec;15(12):1507-15
Six homeoproteins directly activate Myod expression in the gene regulatory networks that control early myogenesis.
Relaix F, Demignon J, Laclef C, Pujol J, Santolini M, Niro C, Lagha M, Rocancourt D, Buckingham M, Maire P
PLoS genetics 2013 Apr;9(4):e1003425
PLoS genetics 2013 Apr;9(4):e1003425
Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks.
Park JS, Ma W, O'Brien LL, Chung E, Guo JJ, Cheng JG, Valerius MT, McMahon JA, Wong WH, McMahon AP
Developmental cell 2012 Sep 11;23(3):637-51
Developmental cell 2012 Sep 11;23(3):637-51
Development of embryonic stem cells in recombinant kidneys.
Rak-Raszewska A, Wilm B, Edgar D, Kenny S, Woolf AS, Murray P
Organogenesis 2012 Oct-Dec;8(4):125-36
Organogenesis 2012 Oct-Dec;8(4):125-36
Integration potential of mouse and human bone marrow-derived mesenchymal stem cells.
Kuzma-Kuzniarska M, Rak-Raszewska A, Kenny S, Edgar D, Wilm B, Fuente Mora C, Davies JA, Murray P
Differentiation; research in biological diversity 2012 Mar;83(3):128-37
Differentiation; research in biological diversity 2012 Mar;83(3):128-37
FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.
Barak H, Huh SH, Chen S, Jeanpierre C, Martinovic J, Parisot M, Bole-Feysot C, Nitschké P, Salomon R, Antignac C, Ornitz DM, Kopan R
Developmental cell 2012 Jun 12;22(6):1191-207
Developmental cell 2012 Jun 12;22(6):1191-207
COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival.
Yu CT, Tang K, Suh JM, Jiang R, Tsai SY, Tsai MJ
Development (Cambridge, England) 2012 Jul;139(13):2330-9
Development (Cambridge, England) 2012 Jul;139(13):2330-9
Ureteric morphogenesis requires Fgfr1 and Fgfr2/Frs2α signaling in the metanephric mesenchyme.
Sims-Lucas S, Di Giovanni V, Schaefer C, Cusack B, Eswarakumar VP, Bates CM
Journal of the American Society of Nephrology : JASN 2012 Apr;23(4):607-17
Journal of the American Society of Nephrology : JASN 2012 Apr;23(4):607-17
Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice.
Asada N, Takase M, Nakamura J, Oguchi A, Asada M, Suzuki N, Yamamura K, Nagoshi N, Shibata S, Rao TN, Fehling HJ, Fukatsu A, Minegishi N, Kita T, Kimura T, Okano H, Yamamoto M, Yanagita M
The Journal of clinical investigation 2011 Oct;121(10):3981-90
The Journal of clinical investigation 2011 Oct;121(10):3981-90
The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification.
Moisan A, Rivera MN, Lotinun S, Akhavanfard S, Coffman EJ, Cook EB, Stoykova S, Mukherjee S, Schoonmaker JA, Burger A, Kim WJ, Kronenberg HM, Baron R, Haber DA, Bardeesy N
Developmental cell 2011 May 17;20(5):583-596
Developmental cell 2011 May 17;20(5):583-596
Tight regulation of p53 activity by Mdm2 is required for ureteric bud growth and branching.
Hilliard S, Aboudehen K, Yao X, El-Dahr SS
Developmental biology 2011 May 15;353(2):354-66
Developmental biology 2011 May 15;353(2):354-66
Alk3 controls nephron number and androgen production via lineage-specific effects in intermediate mesoderm.
Di Giovanni V, Alday A, Chi L, Mishina Y, Rosenblum ND
Development (Cambridge, England) 2011 Jul;138(13):2717-27
Development (Cambridge, England) 2011 Jul;138(13):2717-27
Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development.
Karner CM, Das A, Ma Z, Self M, Chen C, Lum L, Oliver G, Carroll TJ
Development (Cambridge, England) 2011 Apr;138(7):1247-57
Development (Cambridge, England) 2011 Apr;138(7):1247-57
Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network.
Aiden AP, Rivera MN, Rheinbay E, Ku M, Coffman EJ, Truong TT, Vargas SO, Lander ES, Haber DA, Bernstein BE
Cell stem cell 2010 Jun 4;6(6):591-602
Cell stem cell 2010 Jun 4;6(6):591-602
Misexpression of Six2 is associated with heritable frontonasal dysplasia and renal hypoplasia in 3H1 Br mice.
Fogelgren B, Kuroyama MC, McBratney-Owen B, Spence AA, Malahn LE, Anawati MK, Cabatbat C, Alarcon VB, Marikawa Y, Lozanoff S
Developmental dynamics : an official publication of the American Association of Anatomists 2008 Jul;237(7):1767-79
Developmental dynamics : an official publication of the American Association of Anatomists 2008 Jul;237(7):1767-79
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 11562-1-AP( SIX2 Antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SIX2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SIX2. This antibody recognizes human,mouse,rat antigen. The SIX2 antibody has been validated for the following applications: ELISA, IHC, IF, IP, WB analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-SIX2 (IP:11562-1-AP, 3ug; Detection:11562-1-AP 1:500) with HEK-293 cells lysate 2700ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 11562-1-AP(SIX2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 11562-1-AP(SIX2 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
