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- Antigen structure
- References [18]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 17394-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17394-1-AP, RRID:AB_2219748
- Product name
- AlaRS antibody
- Antibody type
- Polyclonal
- Description
- AlaRS antibody (Cat. #17394-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathy.
PDK4-driven lactate accumulation facilitates LPCAT2 lactylation to exacerbate sepsis-induced acute lung injury.
NPM3 functions as a lactyltransferase to promote necroptosis in male diabetic cardiomyopathy mice models via FASN transcription modulation.
Variant-specific interaction of kinectin 1 with the multi-tRNA synthetase complex regulates ER sheet organization.
lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation.
Targeting AARS1-dependent lactylation improves neuronal process plasticity and mitigates cognitive deficits in sepsis-associated encephalopathy.
Comprehensive pan-cancer analysis of AARS1, a newly identified lactyltransferase in human cancers.
KAT8-mediated MDH2 lactylation promotes renal cancer progression by enhancing mitochondrial function and stress resistance.
AARS1-mediated Osterix lactylation promotes its transcriptional activity during osteoblast differentiation.
ASH2L-K312-Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular Carcinoma.
AARS1 Implicates Malignancy and Immune Infiltration in Head and Neck Squamous Cell Carcinoma, Serving as a Prognostic Predictor.
Hexokinase 2-mediated histone H3K18la promotes PAI-1-dependent thrombosis in acute myeloid leukemia via tumor-endothelial crosstalk.
AARS1 promotes endometriosis progression by promoting the lactylation of Snail1†.
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance.
Infection-induced lysine lactylation enables herpesvirus immune evasion.
High-glucose-associated YTHDC1 lactylation reduces the sensitivity of bladder cancer to enfortumab vedotin therapy.
K90 lactylation orchestrates YAP nuclear sequestration by impairing binding with exportin CRM1 and enhances HCC malignancy.
Comprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes.
Hong J, Xu H, Yu L, Yu Z, Chen X, Meng Z, Zhu J, Li J, Zhu M
Cell death and differentiation 2026 Mar;33(3):589-604
Cell death and differentiation 2026 Mar;33(3):589-604
PDK4-driven lactate accumulation facilitates LPCAT2 lactylation to exacerbate sepsis-induced acute lung injury.
Deng Y, Qiu Y, Li X, Gong T, Guo J, Liang H, Yuan Z, Hei Z, Zhang X, Liu Y
Cell death and differentiation 2026 Mar;33(3):557-573
Cell death and differentiation 2026 Mar;33(3):557-573
NPM3 functions as a lactyltransferase to promote necroptosis in male diabetic cardiomyopathy mice models via FASN transcription modulation.
Xu H, Jiang X, Wang F, Meng F, Liu Y, Huang J, Li J, Zhu M
Nature communications 2026 Mar 9;17(1)
Nature communications 2026 Mar 9;17(1)
Variant-specific interaction of kinectin 1 with the multi-tRNA synthetase complex regulates ER sheet organization.
Hosogane M, Siao SY, Hatano A, Huang X, Shichino Y, Watanabe Y, Iwasaki S, Matsumoto M, Nakayama K
iScience 2026 Jan 16;29(1):114303
iScience 2026 Jan 16;29(1):114303
lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation.
Yu L, Zhou N, Zhang XL, Pang XJ, Xing L, Pu YJ, Zhang L, Wu JN, Shu H
Molecular medicine reports 2026 Feb;33(2)
Molecular medicine reports 2026 Feb;33(2)
Targeting AARS1-dependent lactylation improves neuronal process plasticity and mitigates cognitive deficits in sepsis-associated encephalopathy.
Luo S, Lyu Z, Huang H, Zhao J, Li Y, Luo Y
Brain, behavior, and immunity 2026 Feb 17;135:106493
Brain, behavior, and immunity 2026 Feb 17;135:106493
Comprehensive pan-cancer analysis of AARS1, a newly identified lactyltransferase in human cancers.
Fu T, Ni K, Wang Z, Sun S, Liu Y, Wan Q
Cancer cell international 2026 Apr 8;
Cancer cell international 2026 Apr 8;
KAT8-mediated MDH2 lactylation promotes renal cancer progression by enhancing mitochondrial function and stress resistance.
Tang Y, Dai C, Yang H, Yang X, Chen Z, Dou J, Zhang L, Bai T, Zheng J
International journal of biological macromolecules 2025 Sep;322(Pt 1):146571
International journal of biological macromolecules 2025 Sep;322(Pt 1):146571
AARS1-mediated Osterix lactylation promotes its transcriptional activity during osteoblast differentiation.
Nian F, Guo L, Fei Z, Yang M, Chen L, Zhang Y, Zhang B, Qian Y, Zhang Z
Acta histochemica 2025 Sep;127(3):152273
Acta histochemica 2025 Sep;127(3):152273
ASH2L-K312-Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular Carcinoma.
Han H, Wang S, Ma L, Yin H, Cheng X, Wang Y, Xia S, Zhang Y, Zhang Y, Zhu R, Liu C, Zhao D, Gu X, Zhu H, Yuan Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e09477
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e09477
AARS1 Implicates Malignancy and Immune Infiltration in Head and Neck Squamous Cell Carcinoma, Serving as a Prognostic Predictor.
Chen S, You Y, Zhu F, Zhang Z, Shi J, Tian Z
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2025 Nov;54(10):1037-1052
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2025 Nov;54(10):1037-1052
Hexokinase 2-mediated histone H3K18la promotes PAI-1-dependent thrombosis in acute myeloid leukemia via tumor-endothelial crosstalk.
Bai Q, Qiu YX, Zeng H, Yao LH, Zhong FM, Xu YM, Zhang J, Huang B, Liu J, Shi H, Hou X, Wang ZH, Deng KY, Wang XZ
Nature communications 2025 Nov 19;16(1):10168
Nature communications 2025 Nov 19;16(1):10168
AARS1 promotes endometriosis progression by promoting the lactylation of Snail1†.
Liu L, Du S, Liu J, Wang M, Ge X, Yue C, Lu C, Yu Z
Biology of reproduction 2025 Nov 14;113(5):1209-1218
Biology of reproduction 2025 Nov 14;113(5):1209-1218
NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance.
Lin J, Yin Y, Cao J, Zhang Y, Chen J, Chen R, Zou B, Huang C, Lv Y, Xu S, Yang H, Lin P, Xie D
Cell discovery 2025 May 28;11(1):52
Cell discovery 2025 May 28;11(1):52
Infection-induced lysine lactylation enables herpesvirus immune evasion.
Tyl MD, Merengwa VU, Cristea IM
Science advances 2025 Jan 10;11(2):eads6215
Science advances 2025 Jan 10;11(2):eads6215
High-glucose-associated YTHDC1 lactylation reduces the sensitivity of bladder cancer to enfortumab vedotin therapy.
Xing Z, Yang T, Li X, Xu H, Hong Y, Shao S, Li T, Ye L, Li Y, Jin X, Wei Y
Cell reports 2025 Apr 22;44(4):115545
Cell reports 2025 Apr 22;44(4):115545
K90 lactylation orchestrates YAP nuclear sequestration by impairing binding with exportin CRM1 and enhances HCC malignancy.
Wang L, Zeng T, Wang Y, Wang G, Yu W, Zhang J, Shi Y, Li J, Ding J
Cancer letters 2024 Dec 5;611:217386
Cancer letters 2024 Dec 5;611:217386
Comprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes.
Li L, Jiang D, Liu H, Guo C, Zhao R, Zhang Q, Xu C, Qin Z, Feng J, Liu Y, Wang H, Chen W, Zhang X, Li B, Bai L, Tian S, Tan S, Yu Z, Chen L, Huang J, Zhao JY, Hou Y, Ding C
Nature communications 2023 Mar 29;14(1):1751
Nature communications 2023 Mar 29;14(1):1751
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 17394-1-AP(AARS antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 17394-1-AP(AARS antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The AlaRS antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human AlaRS. This antibody recognizes human,mouse,rat antigen. The AlaRS antibody has been validated for the following applications: ELISA, WB, IHC analysis.
