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LearnNB100-122
antibody from Novus Biologicals
Targeting: EPAS1
bHLHe73, HIF2A, HLF, MOP2, PASD2
Western blot
ELISA Immunocytochemistry Immunoprecipitation Immunohistochemistry Flow cytometry Gel shift Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [642]
- Comments [0]
- Validations
- Western blot [11]
- Immunohistochemistry [3]
- Chromatin Immunoprecipitation [2]
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- Product number
- NB100-122 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-122, RRID:AB_10002593
- Product name
- Rabbit Polyclonal HIF-2 alpha/EPAS1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. This HIF-2 alpha/EPAS1 Antibody is specific for HIF-2 alpha/EPAS, and does not cross-react with HIF-1 alpha.
- Reactivity
- Human, Mouse, Rat, Hamster, Rabbit, Sheep, Simian
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Concentration
- 1.0 mg/ml
- Storage
- Store at -20 degreesC.
Submitted references The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma.
Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients.
Mitochondrial Dysfunction Inhibits Hypoxia-Induced HIF-1α Stabilization and Expression of Its Downstream Targets.
Hypoxia compensates cell cycle arrest with progenitor differentiation during angiogenesis.
Hypoxia-Inducible Factor 1α (HIF-1α) Counteracts the Acute Death of Cells Transplanted into the Injured Spinal Cord.
A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism.
Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models.
Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease.
Mucosal inflammation downregulates PHD1 expression promoting a barrier-protective HIF-1α response in ulcerative colitis patients.
Co-culture of human fibroblasts, smooth muscle and endothelial cells promotes osteopontin induction in hypoxia.
Hypoxia-Inducible Factor-2α Reprograms Liver Macrophages to Protect Against Acute Liver Injury Through the Production of Interleukin-6.
Deregulated hypoxic response in myeloid cells: A model for high-altitude pulmonary oedema (HAPE).
Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α.
Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness.
Hypoxia and transforming growth factor β1 regulation of long non-coding RNA transcriptomes in human pulmonary fibroblasts.
YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells.
Ex-Vivo Treatment of Tumor Tissue Slices as a Predictive Preclinical Method to Evaluate Targeted Therapies for Patients with Renal Carcinoma.
A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells.
Gamma-Aminobutyric Acid Increases Erythropoietin by Activation of Citrate Cycle and Stimulation of Hypoxia-Inducible Factors Expression in Rats.
Hypoxia-Inducible Factor Inhibitors Derived from Marine Products Suppress a Murine Model of Neovascular Retinopathy.
VEGFC acts as a double-edged sword in renal cell carcinoma aggressiveness.
Expression and role of HIF-1α and HIF-2α in tissue regeneration: a study of hypoxia in house gecko tail regeneration.
TRIB3 Promotes the Proliferation and Invasion of Renal Cell Carcinoma Cells via Activating MAPK Signaling Pathway.
Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma.
Hypoxia inhibits TNF-α-induced TSLP expression in keratinocytes.
The prognostic value of hypoxia-inducible factor-1α in advanced cancer survivors: a meta-analysis with trial sequential analysis.
Involvement of A3 Adenosine Receptor in Neuroblastoma Progression via Modulation of the Hypoxic/Angiogenic Pathway.
Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis.
A genetic mouse model of severe iron deficiency anemia reveals tissue-specific transcriptional stress responses and cardiac remodeling.
Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism.
The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension.
Tumor infiltrating mast cells determine oncogenic HIF-2α-conferred immune evasion in clear cell renal cell carcinoma.
Astrocytic cystine/glutamate antiporter is a key regulator of erythropoietin expression in the ischemic retina.
Sox17 is required for endothelial regeneration following inflammation-induced vascular injury.
A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension.
Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer.
Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis.
Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway.
SMAD family member 3 (SMAD3) and SMAD4 repress HIF2α-dependent iron-regulatory genes.
A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma.
Hypoxia-induced Changes in SUMO Conjugation Affect Transcriptional Regulation Under Low Oxygen.
Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.
Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis.
Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation.
NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms.
Putative Role of Nuclear Factor-Kappa B But Not Hypoxia-Inducible Factor-1α in Hypoxia-Dependent Regulation of Oxidative Stress in Hematopoietic Stem and Progenitor Cells.
Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment.
Hypoxic Environment Promotes Barrier Formation in Human Intestinal Epithelial Cells through Regulation of MicroRNA 320a Expression.
Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity.
HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer.
Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload.
ONECUT2 is a driver of neuroendocrine prostate cancer.
HIF-1α-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia.
Hypoxia-inducible factor: role in cell survival in superoxide dismutase overexpressing mice after neonatal hypoxia-ischemia.
Platelet HIF-2α promotes thrombogenicity through PAI-1 synthesis and extracellular vesicle release.
SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors -1α and -2α in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets.
Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk.
Differential regulation of estrogen in iron metabolism in astrocytes and neurons.
Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease.
Histone H3K9 demethylase JMJD1A is a co-activator of erythropoietin expression under hypoxia.
Glycolysis Regulates Human Embryonic Stem Cell Self-Renewal under Hypoxia through HIF-2α and the Glycolytic Sensors CTBPs.
ERK1/2 phosphorylates HIF-2α and regulates its activity by controlling its CRM1-dependent nuclear shuttling.
Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or Presence of Hif2α in Pheochromocytoma Cells.
Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm.
Glucocorticoid Impaired the Wound Healing Ability of Endothelial Progenitor Cells by Reducing the Expression of CXCR4 in the PGE2 Pathway.
Hypoxic stabilization of mRNA is HIF-independent but requires mtROS.
Immunohistochemistry of the circadian clock in mouse and human vascular tissues.
Chromatin Immunoprecipitation of HIF-α in Breast Tumor Cells Using Wild Type and Loss of Function Models.
Analysis of Hypoxia and the Hypoxic Response in Tumor Xenografts.
The hypoxia inducible factor/erythropoietin (EPO)/EPO receptor pathway is disturbed in a rat model of chronic kidney disease related anemia.
Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1α activation.
The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma.
The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma.
Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen.
Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer.
BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion.
Intra-tumoral treatment with oxygen-ozone in glioblastoma: A systematic literature search and results of a case series.
Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis.
Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis.
HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia.
The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells.
PACAP and VIP regulate hypoxia-inducible factors in neuroblastoma cells exposed to hypoxia.
Transient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration.
Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner.
PEGylated IL-11 (BBT-059): A Novel Radiation Countermeasure for Hematopoietic Acute Radiation Syndrome.
Enhancement of glycolysis by inhibition of oxygen-sensing prolyl hydroxylases protects alveolar epithelial cells from acute lung injury.
Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation.
Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B.
Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents.
Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling.
SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α.
Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells.
Consequences of VHL Loss on Global DNA Methylome.
Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition.
Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer.
Targeting the Mevalonate Pathway Suppresses VHL-Deficient CC-RCC through an HIF-Dependent Mechanism.
Endogenous HIF2A reporter systems for high-throughput functional screening.
Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Protein (TIP30).
PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα.
Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: a "U-shaped" relationship.
A Crucial Role of CXCL14 for Promoting Regulatory T Cells Activation in Stroke.
Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis.
Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis.
Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway.
Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice.
The pVHL172 isoform is not a tumor suppressor and up-regulates a subset of pro-tumorigenic genes including TGFB1 and MMP13.
Histone methylase MLL1 coordinates with HIF and regulate lncRNA HOTAIR expression under hypoxia.
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis.
Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1α.
Selective tubular activation of hypoxia-inducible factor-2α has dual effects on renal fibrosis.
KDM4A regulates HIF-1 levels through H3K9me3.
The prognosis outcome of oral squamous cell carcinoma using HIF-2α.
Trophoblast survival signaling during human placentation requires HSP70 activation of MMP2-mediated HBEGF shedding.
Hypoxia favors myosin heavy chain beta gene expression in an Hif-1alpha-dependent manner.
Pharmacological HIF-inhibition attenuates postoperative adhesion formation.
Hypoxia-inducible factor 2α (HIF-2α) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity.
VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.
Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis.
Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction.
Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress.
HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism.
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice.
HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium.
Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells.
HIF-2α dictates the susceptibility of pancreatic cancer cells to TRAIL by regulating survivin expression.
Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma.
HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death.
Decreased expression of acetyl-CoA synthase 2 promotes metastasis and predicts poor prognosis in hepatocellular carcinoma.
Deregulated expression of miR-29a-3p, miR-494-3p and miR-660-5p affects sensitivity to tyrosine kinase inhibitors in CML leukemic stem cells.
Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations.
The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.
Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye.
Stable knockdown of CREB, HIF-1 and HIF-2 by replication-competent retroviruses abrogates the responses to hypoxia in hepatocellular carcinoma.
Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer.
Induction of dormancy in hypoxic human papillomavirus-positive cancer cells.
EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α.
Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma.
Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment.
Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia.
Hypoxia-activated prodrug enhances therapeutic effect of sunitinib in melanoma.
Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression.
Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts.
Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer.
PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression.
Hydroxyl-HIF2-alpha is potential therapeutic target for renal cell carcinomas.
HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells.
Cellular Profiles and Molecular Mediators of Lesion Cascades in the Placode in Human Open Spinal Neural Tube Defects.
Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function.
Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling.
Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells.
Lack of P4H-TM in mice results in age-related retinal and renal alterations.
Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel-Lindau Gene Mutation Status.
MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer.
FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model.
Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells.
Activation of islet 5-HT4 receptor regulates glycemic control through promoting insulin secretion.
Chondromodulin-1 ameliorates osteoarthritis progression by inhibiting HIF-2α activity.
Analysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells.
Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy.
HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia.
HIF-2α in Resting Macrophages Tempers Mitochondrial Reactive Oxygen Species To Selectively Repress MARCO-Dependent Phagocytosis.
Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia.
Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation.
Erratum to: Rectocutaneous fistula with transmigration of the suture: a rare delayed complication of vault fixation with the sacrospinous ligament.
A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity.
Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models.
Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer.
Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver.
A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT.
Notch-independent RBPJ controls angiogenesis in the adult heart.
Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner.
HIFI-α activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer.
Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2α.
Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity.
PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species.
Thrombopoietin induces hematopoiesis from mouse ES cells via HIF-1α-dependent activation of a BMP4 autoregulatory loop.
Genome-wide analysis of HIF-2α chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions.
EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance.
Hypoxia upregulates HIG2 expression and contributes to bevacizumab resistance in glioblastoma.
jSplice: a high-performance method for accurate prediction of alternative splicing events and its application to large-scale renal cancer transcriptome data.
Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution.
Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia.
Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation.
The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells.
Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis.
Histone modification profiling reveals differential signatures associated with human embryonic stem cell self-renewal and differentiation.
PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia.
Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth.
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.
Regulation of glucose metabolism by p62/SQSTM1 through HIF1α.
LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways.
Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion.
Differential hypoxic response of human choroidal and retinal endothelial cells proposes tissue heterogeneity of ocular angiogenesis.
Hypoxia-Dependent HIF-1 Activation Impacts on Tissue Remodeling in Graves' Ophthalmopathy-Implications for Smoking.
Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration.
pVHL-mediated degradation of HIF-2α regulates estrogen receptor α expression in normoxic breast cancer cells.
Bidirectional signalling between EphA2 and ephrinA1 increases tubular cell attachment, laminin secretion and modulates erythropoietin expression after renal hypoxic injury.
Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model.
CD14/TLR4 priming potentially recalibrates and exerts anti-tumor efficacy in tumor associated macrophages in a mouse model of pancreatic carcinoma.
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA.
Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling.
Cross regulation between hypoxia-inducible transcription factor-1α (HIF-1α) and transforming growth factor (TGF)-ß1 mediates nickel oxide nanoparticles (NiONPs)-induced pulmonary fibrosis.
Prolyl-4-Hydroxylase 2 Potentially Contributes to Hepatocellular Carcinoma-Associated Erythrocytosis by Maintaining Hepatocyte Nuclear Factor-4α Expression.
Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes.
Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes.
Differential effects of HIF-α isoforms on apoptosis in renal carcinoma cell lines.
Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.
Pharmacological inhibition of FTO.
The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment.
HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression.
Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis.
The In Vitro and In Vivo Activity of the Microtubule Disruptor STX140 Is Mediated by Hif-1 Alpha and CAIX Expression.
Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML.
HIF-2α-induced chemokines stimulate motility of fibroblast-like synoviocytes and chondrocytes into the cartilage-pannus interface in experimental rheumatoid arthritis mouse models.
The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment.
PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation.
Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat.
Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis.
FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation.
Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition.
HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma.
Increased expression of HIF2α during iron deficiency-associated megakaryocytic differentiation.
Impaired expression of HIF-2α induces compensatory expression of HIF-1α for the recovery from anemia.
STAT3 and HIF1α Signaling Drives Oncogenic Cellular Phenotypes in Malignant Peripheral Nerve Sheath Tumors.
Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27.
Maternal intestinal HIF-2α is necessary for sensing iron demands of lactation in mice.
Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD.
Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT).
Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma.
Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function.
Hypoxia promotes dissemination and colonization in new bone marrow niches in Waldenström macroglobulinemia.
HIF2α signaling inhibits adherens junctional disruption in acute lung injury.
The inhibitory effect of hypoxic cytotoxin on the expansion of cancer stem cells in ovarian cancer.
Hypoxia up-regulates SERPINB3 through HIF-2α in human liver cancer cells.
Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion.
Oxygen Sensitivity of Placental Trophoblast Connexins 43 and 46: A Role in Preeclampsia?
REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia.
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance.
High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss.
Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype.
Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system.
Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection.
Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer.
Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis.
Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation.
HIF1α and HIF2α exert distinct nutrient preferences in renal cells.
Deletion of hypoxia-inducible factor-1α in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation.
Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2.
HIF-2α regulates NANOG expression in human embryonic stem cells following hypoxia and reoxygenation through the interaction with an Oct-Sox cis regulatory element.
Lenticular cytoprotection, part 2: link between glycogen synthase kinase-3β, epithelial to mesenchymal transition, and mitochondrial depolarization.
Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model.
Hypoxia-inducible factor-1α restricts the anabolic actions of parathyroid hormone.
Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2α and ETS1.
miR455 is linked to hypoxia signaling and is deregulated in preeclampsia.
Fructose-1,6-bisphosphatase opposes renal carcinoma progression.
Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development.
Submersion and hypoxia inhibit ciliated cell differentiation in a notch-dependent manner.
Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1α pathway.
Decreased expression of cystathionine β-synthase promotes glioma tumorigenesis.
Hypoxia-inducible factors enhance glutamate signaling in cancer cells.
Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst.
Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy.
Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion.
Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR.
Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X.
Protein profiling of Helicobacter pylori-associated gastric cancer.
CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen - changes with oxygen dosage.
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment.
FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter.
Calpains promote neutrophil recruitment and bacterial clearance in an acute bacterial peritonitis model.
EAF2 suppresses hypoxia-induced factor 1α transcriptional activity by disrupting its interaction with coactivator CBP/p300.
Epidermal deletion of HIF-2α stimulates wound closure.
STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells.
Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression.
Hypoxia inducible factor 2α/insulin-like growth factor receptor signal loop supports the proliferation and Oct-4 maintenance of mouse germline stem cells.
Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation.
Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein.
Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor.
Modulation of Dcytb (Cybrd 1) expression and function by iron, dehydroascorbate and Hif-2α in cultured cells.
Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway.
Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells.
Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer.
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Regulation of the HIF-system in human macrophages--differential regulation of HIF-α subunits under sustained hypoxia.
The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells.
Expression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness.
Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury.
Dysregulated D-dopachrome tautomerase, a hypoxia-inducible factor-dependent gene, cooperates with macrophage migration inhibitory factor in renal tumorigenesis.
CTGF is a therapeutic target for metastatic melanoma.
Interaction between PARP-1 and HIF-2α in the hypoxic response.
Inflammatory cytokine tumor necrosis factor α suppresses neuroprotective endogenous erythropoietin from astrocytes mediated by hypoxia-inducible factor-2α.
Hypoxia-inducible factor-2α (HIF-2α), but not HIF-1α, is essential for hypoxic induction of class III β-tubulin expression in human glioblastoma cells.
LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia.
Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype.
A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α.
Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells.
The role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways.
Role of magnesium ions on osteogenic response in bone marrow stromal cells.
Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells.
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression.
Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A.
Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver.
Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling.
Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.
STAT3 or USF2 contributes to HIF target gene specificity.
Environmental oxygen tension regulates the energy metabolism and self-renewal of human embryonic stem cells.
Copper deficiency leads to anemia, duodenal hypoxia, upregulation of HIF-2α and altered expression of iron absorption genes in mice.
Downregulation of carbonic anhydrase IX promotes Col10a1 expression in chondrocytes.
ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement.
Prolyl-4-hydroxylase 3 (PHD3) expression is downregulated during epithelial-to-mesenchymal transition.
Prognostic value and clinicopathological differences of HIFs in colorectal cancer: evidence from meta-analysis.
MicroRNA-17, 20a regulates the proangiogenic function of tumor-associated macrophages via targeting hypoxia-inducible factor 2α.
Xanthine oxidase mediates hypoxia-inducible factor-2α degradation by intermittent hypoxia.
Lenticular cytoprotection. Part 1: the role of hypoxia inducible factors-1α and -2α and vascular endothelial growth factor in lens epithelial cell survival in hypoxia.
VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy.
MYC degradation under low O2 tension promotes survival by evading hypoxia-induced cell death.
Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels.
HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium.
Activin A regulation under global hypoxia in developing mouse brain.
Role of hepatic resident and infiltrating macrophages in liver repair after acute injury.
Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.
A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.
HIF isoforms in the skin differentially regulate systemic arterial pressure.
Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways.
Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells.
Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen.
Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.
Hypoxia-inducible factor-2α and TGF-β signaling interact to promote normoxic glomerular fibrogenesis.
Silencing of GLUT-1 inhibits sensitization of oral cancer cells to cisplatin during hypoxia.
Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis.
Activation of HIF2α in kidney proximal tubule cells causes abnormal glycogen deposition but not tumorigenesis.
The protein tyrosine phosphatase receptor type J is regulated by the pVHL-HIF axis in clear cell renal cell carcinoma.
HIF2A and IGF2 expression correlates in human neuroblastoma cells and normal immature sympathetic neuroblasts.
HIF2A and IGF2 expression correlates in human neuroblastoma cells and normal immature sympathetic neuroblasts.
Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation.
Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling.
Collagen prolyl hydroxylases are essential for breast cancer metastasis.
CDH5 is specifically activated in glioblastoma stemlike cells and contributes to vasculogenic mimicry induced by hypoxia.
Sirtuin-7 inhibits the activity of hypoxia-inducible factors.
Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice.
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer.
The accumulations of HIF-1α and HIF-2α by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells.
Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients.
Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers.
Regulation of the Hif-system by micro-RNA 17 and 20a - role during monocyte-to-macrophage differentiation.
Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis.
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.
Integrated molecular analysis of clear-cell renal cell carcinoma.
Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection.
Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction.
Erythropoietin is a hypoxia inducible factor-induced protective molecule in experimental autoimmune neuritis.
NF-κB inhibition by bortezomib permits IFN-γ-activated RIP1 kinase-dependent necrosis in renal cell carcinoma.
IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation.
Transcription factors Sp1 and Hif2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epithelial cells during hypoxia.
Expression of VHL Causes Three-Dimensional Morphological Changes in Renal Cells Indicative of Proximal Tubule Differentiation.
Positive feedback loop and synergistic effects between hypoxia-inducible factor-2α and stearoyl-CoA desaturase-1 promote tumorigenesis in clear cell renal cell carcinoma.
Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts.
The inhibition of HIF-2α on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation.
Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential.
Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer.
Suppression of glioma progression by Egln3.
EMT and stem cell-like properties associated with HIF-2α are involved in arsenite-induced transformation of human bronchial epithelial cells.
L-2-Oxothiazolidine-4-carboxylic acid or α-lipoic acid attenuates airway remodeling: involvement of nuclear factor-κB (NF-κB), nuclear factor erythroid 2p45-related factor-2 (Nrf2), and hypoxia-inducible factor (HIF).
Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF.
Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release.
Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C.
Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells.
AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma.
The hypoxia-inducible factor-C/EBPα axis controls ethanol-mediated hepcidin repression.
Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma.
Upstream stimulatory factor 2 and hypoxia-inducible factor 2α (HIF2α) cooperatively activate HIF2 target genes during hypoxia.
Tumor microvasculature with endothelial fenestrations in VHL null clear cell renal cell carcinomas as a potent target of anti-angiogenic therapy.
Co-expression of XIAP and cyclin D1 complex correlates with a poor prognosis in patients with hepatocellular carcinoma.
Effects of oxygen on zonal marker expression in human articular chondrocytes.
An oxygen-regulated switch in the protein synthesis machinery.
Knockdown of von Hippel-Lindau protein decreases lung cancer cell proliferation and colonization.
Chronic nicotine induces hypoxia inducible factor-2α in perinatal rat adrenal chromaffin cells: role in transcriptional upregulation of KATP channel subunit Kir6.2.
Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR.
Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction.
Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential.
The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO.
Blockade of p53 by HIF-2α, but not HIF-1α, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells.
Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1α-mediated mRNA transcription and continuous protein synthesis.
Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis.
Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma.
Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma.
JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma.
Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis.
Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2α.
Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition.
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors.
Hypoxia-inducible factor-1 (HIF-1) promotes LDL and VLDL uptake through inducing VLDLR under hypoxia.
Hypoxia modulates the undifferentiated phenotype of human renal inner medullary CD133+ progenitors through Oct4/miR-145 balance.
Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1.
Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element.
Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia.
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
Ultraviolet A regulates the stemness of human adipose tissue-derived mesenchymal stem cells through downregulation of the HIF-1α via activation of PGE(2)-cAMP signaling.
Pseudolaric acid B-driven phosphorylation of c-Jun impairs its role in stabilizing HIF-1alpha: a novel function-converter model.
Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism.
The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling.
Functional importance of Dicer protein in the adaptive cellular response to hypoxia.
Hypoxia-mediated impairment of the mitochondrial respiratory chain inhibits the bactericidal activity of macrophages.
HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs.
Prostate cancer cell lines under hypoxia exhibit greater stem-like properties.
Assessment of hypoxia inducible factor levels in cancer cell lines upon hypoxic induction using a novel reporter construct.
Multidimensional poverty and child survival in India.
OxLDL and macrophage survival: essential and oxygen-independent involvement of the Hif-pathway.
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation.
Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2α through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms.
Chronic hypoxia upregulates adenosine 2a receptor expression in chromaffin cells via hypoxia inducible factor-2α: role in modulating secretion.
MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia.
Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia.
Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis.
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia.
Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice.
Normoxic expression of hypoxia-inducible factor 1 in rat Leydig cells in vivo and in vitro.
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.
A novel specific application of pyruvate protects the mouse retina against white light damage: differential stabilization of HIF-1α and HIF-2α.
Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells.
NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning.
Captopril modulates hypoxia-inducible factors and erythropoietin responses in a murine model of total body irradiation.
Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2{alpha}) in intestinal epithelial cells.
Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia.
Lack of iron-related phenotype in Sp6 intestinal knockout mice.
MCM proteins are negative regulators of hypoxia-inducible factor 1.
The hypoxia-associated factor switches cells from HIF-1α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion.
Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation.
Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration.
Retina-specific activation of a sustained hypoxia-like response leads to severe retinal degeneration and loss of vision.
Immunohistochemical basis for adjuvant anti-angiogenic targeted therapy for renal carcinoid: initial case report.
Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells.
Evolutionary conserved regulation of HIF-1β by NF-κB.
Hypoxia-inducible factor-1α regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis.
Oxygen regulation of the epithelial Na channel in the collecting duct.
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension.
VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration.
Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice.
Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation.
Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis.
Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis.
Association of elevated HIF-2α levels with low Beclin 1 expression and poor prognosis in patients with chondrosarcoma.
Crocidolite asbestos-induced signal pathway dysregulation in mesothelial cells.
New role for granulocyte colony-stimulating factor-induced extracellular signal-regulated kinase 1/2 in histone modification and retinoic acid receptor α recruitment to gene promoters: relevance to acute promyelocytic leukemia cell differentiation.
Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice.
Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma.
HIF-2 directly activates CD82 gene expression in endothelial cells.
Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy.
Hypoxia induces PTHrP gene transcription in human cancer cells through the HIF-2α.
Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion.
Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis.
The VHL-dependent regulation of microRNAs in renal cancer.
Cross-species comparison of genomewide gene expression profiles reveals induction of hypoxia-inducible factor-responsive genes in iron-deprived intestinal epithelial cells.
Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1.
Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells.
Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms.
COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion.
Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia.
The efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 compared with rapamycin in renal cell carcinoma.
Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth.
Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis.
Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors.
Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.
Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha.
PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types.
Fumarase tumor suppressor gene and MET oncogene cooperate in upholding transformation and tumorigenesis.
RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha.
The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2.
Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling.
Disseminated pyoderma gangrenosum: role for vascular endothelial growth factor and hypoxia inducible factor-2.
The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction.
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization.
A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo.
Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability.
Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons.
Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy.
Red wine polyphenols prevent acceleration of neovascularization by angiotensin II in the ischemic rat hindlimb.
HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury.
HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice.
Loss of VHL and hypoxia provokes PAX2 up-regulation in clear cell renal cell carcinoma.
PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma.
PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma.
Signaling by hypoxia-inducible factors is critical for ovulation in mice.
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia.
Hypoxia decreases insulin signaling pathways in adipocytes.
Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells.
Human cancers converge at the HIF-2alpha oncogenic axis.
Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia.
Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic hepatocytes.
Iron transporters are differentially regulated by dietary iron, and modifications are associated with changes in manganese metabolism in young pigs.
Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor.
Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis.
VHL Type 2B gene mutation moderates HIF dosage in vitro and in vivo.
Myocardial hypertrophy overrides the angiogenic response to hypoxia.
A Key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells.
Hypoxia-inducible factor-2alpha regulates the expression of TRAIL receptor DR5 in renal cancer cells.
Activation of the VEGFR1 chromatin domain: an angiogenic signal-ETS1/HIF-2alpha regulatory axis.
Constitutive expression of HIF-1alpha and HIF-2alpha in bone marrow stromal cells differentially promotes their proangiogenic properties.
Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance.
The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential.
Oxygenated perfluorochemicals improve cell survival during reoxygenation by pacifying mitochondrial activity.
Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein.
HIV-1 upregulates VEGF in podocytes.
Enhancement of Angiogenesis Through Stabilization of Hypoxia-inducible Factor-1 by Silencing Prolyl Hydroxylase Domain-2 Gene
Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family.
Proteasomal activity in placentas from women with preeclampsia and intrauterine growth restriction: implications for expression of HIF-alpha proteins.
PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis.
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure.
Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins.
Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line.
Regulation of hypoxia-inducible factor-1alpha by NF-kappaB.
Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha.
Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene.
Placental HIFs as markers of cerebral hypoxic distress in fetal mice.
Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation.
Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.
Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy.
Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth.
The microenvironment for erythropoiesis is regulated by HIF-2alpha through VCAM-1 in endothelial cells.
HIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle.
Involvement of chloride channels in TGF-beta1-induced apoptosis of human bronchial epithelial cells.
The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha.
Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells.
Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency.
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity.
Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha.
NAD(P)H oxidases regulate HIF-2alpha protein expression.
Hypoxia-inducible factors HIF-1alpha and HIF-2alpha are decreased in an experimental model of severe respiratory distress syndrome in preterm lambs.
The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.
HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation.
Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood.
VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail.
Prolyl-hydroxylase inhibition and HIF activation in osteoblasts promotes an adipocytic phenotype.
Acute postnatal ablation of Hif-2alpha results in anemia.
von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis.
Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation.
Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.
Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.
Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands.
Hypoxia-inducible factors in the first trimester human lung.
Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney.
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo.
The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes.
Regulation of the chemokine receptor CXCR4 and metastasis by hypoxia-inducible factor in non small cell lung cancer cell lines.
Regulation of the chemokine receptor CXCR4 and metastasis by hypoxia-inducible factor in non small cell lung cancer cell lines.
Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo.
Differentiation arrest by hypoxia.
Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII.
Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors.
Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2.
Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells.
Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc.
Calcium signaling stimulates translation of HIF-alpha during hypoxia.
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.
Hypoxia and hypoxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells.
Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1.
Dynamic HIF1A regulation during human placental development.
Primary cilium formation requires von hippel-lindau gene function in renal-derived cells.
Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis.
Priming-dependent phosphorylation and regulation of the tumor suppressor pVHL by glycogen synthase kinase 3.
Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17.
Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment.
Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells.
Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells.
Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex.
Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase.
Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer.
Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung.
Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor.
Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma.
Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.
Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta.
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes.
Divergent expression patterns for hypoxia-inducible factor-1beta and aryl hydrocarbon receptor nuclear transporter-2 in developing kidney.
Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.
Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae.
Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha.
Role of iron (II)-2-oxoglutarate-dependent dioxygenases in the generation of hypoxia-induced phosphatidic acid through HIF-1/2 and von Hippel-Lindau-independent mechanisms.
Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer.
Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer.
p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment.
HIF activation by pH-dependent nucleolar sequestration of VHL.
Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1.
Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma.
Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.
In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations.
The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells.
Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha.
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.
Specific oncolytic effect of a new hypoxia-inducible factor-dependent replicative adenovirus on von Hippel-Lindau-defective renal cell carcinomas.
Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein.
Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor.
Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha.
Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene.
Induction of T-type calcium channel gene expression by chronic hypoxia.
Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3'-kinase/protein kinase B in prostate cancer cells.
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha.
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha.
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth.
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth.
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.
Peritubular capillary loss after mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia-inducible factor-1 alpha.
Peritubular capillary loss after mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia-inducible factor-1 alpha.
The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen.
Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation.
von Hippel-Lindau protein complex is regulated by cell density.
Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells.
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.
Overexpression of the EGFR/FKBP12/HIF-2alpha pathway identified in childhood astrocytomas by angiogenesis gene profiling.
HIF-2alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells.
HIF-2alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells.
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha.
Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance.
Positive expression of HIF-2alpha/EPAS1 in invasive bladder cancer.
Positive expression of HIF-2alpha/EPAS1 in invasive bladder cancer.
Activation of vascular endothelial growth factor A transcription in tumorigenic glioblastoma cell lines by an enhancer with cell type-specific DNase I accessibility.
Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy.
Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect.
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma.
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma.
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension.
Histologic atrial myolysis is associated with atrial fibrillation after cardiac operation.
Histologic atrial myolysis is associated with atrial fibrillation after cardiac operation.
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression.
A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha).
Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis.
Role of exon 2-encoded beta -domain of the von Hippel-Lindau tumor suppressor protein.
Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.
Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis.
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein.
Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta.
Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta.
EPAS1 trans-activation during hypoxia requires p42/p44 MAPK.
EPAS1 trans-activation during hypoxia requires p42/p44 MAPK.
[Fibroxanthoma retroperitonei].
Chen L, Wang Z, Xu Q, Liu Y, Chen L, Guo S, Wang H, Zeng K, Liu J, Zeng S, Yu L
Theranostics 2020;10(8):3562-3578
Theranostics 2020;10(8):3562-3578
Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell Renal Cell Carcinoma patients.
Fabbri L, Dufies M, Lacas-Gervais S, Gardie B, Gad-Lapiteau S, Parola J, Nottet N, Meyenberg Cunha de Padua M, Contenti J, Borchiellini D, Ferrero JM, Leclercq NR, Ambrosetti D, Mograbi B, Richard S, Viotti J, Chamorey E, Sadaghianloo N, Rouleau M, Craigen WJ, Mari B, Clavel S, Pagès G, Pouysségur J, Bost F, Mazure NM
Theranostics 2020;10(6):2696-2713
Theranostics 2020;10(6):2696-2713
Mitochondrial Dysfunction Inhibits Hypoxia-Induced HIF-1α Stabilization and Expression of Its Downstream Targets.
van Gisbergen MW, Offermans K, Voets AM, Lieuwes NG, Biemans R, Hoffmann RF, Dubois LJ, Lambin P
Frontiers in oncology 2020;10:770
Frontiers in oncology 2020;10:770
Hypoxia compensates cell cycle arrest with progenitor differentiation during angiogenesis.
Acosta-Iborra B, Tiana M, Maeso-Alonso L, Hernández-Sierra R, Herranz G, Santamaria A, Rey C, Luna R, Puente-Santamaria L, Marques MM, Marin MC, Del Peso L, Jiménez B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 May;34(5):6654-6674
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 May;34(5):6654-6674
Hypoxia-Inducible Factor 1α (HIF-1α) Counteracts the Acute Death of Cells Transplanted into the Injured Spinal Cord.
David BT, Curtin JJ, Goldberg DC, Scorpio K, Kandaswamy V, Hill CE
eNeuro 2020 May Jun;7(3)
eNeuro 2020 May Jun;7(3)
A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism.
Ho JJD, Balukoff NC, Theodoridis PR, Wang M, Krieger JR, Schatz JH, Lee S
Nature communications 2020 May 29;11(1):2677
Nature communications 2020 May 29;11(1):2677
Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models.
Park JH, Kim MJ, Kim WJ, Kwon KD, Ha KT, Choi BT, Lee SY, Shin HK
Cancer letters 2020 May 28;478:71-81
Cancer letters 2020 May 28;478:71-81
Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease.
Varghese J, Varghese James J, Karthikeyan M, Rasalkar K, Raghavan R, Sukumaran A, Premkumar PS, Eapen CE, Jacob M
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2020 Mar;58:126442
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2020 Mar;58:126442
Mucosal inflammation downregulates PHD1 expression promoting a barrier-protective HIF-1α response in ulcerative colitis patients.
Brown E, Rowan C, Strowitzki MJ, Fagundes RR, Faber KN, Güntsch A, Halligan DN, Kugler J, Jones F, Lee CT, Doherty G, Taylor CT
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):3732-3742
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):3732-3742
Co-culture of human fibroblasts, smooth muscle and endothelial cells promotes osteopontin induction in hypoxia.
Sadaghianloo N, Contenti J, Dufies M, Parola J, Rouleau M, Lee S, Peyron JF, Fabbri L, Hassen-Khodja R, Pouysségur J, Bost F, Jean-Baptiste E, Dardik A, Mazure NM
Journal of cellular and molecular medicine 2020 Mar;24(5):2931-2941
Journal of cellular and molecular medicine 2020 Mar;24(5):2931-2941
Hypoxia-Inducible Factor-2α Reprograms Liver Macrophages to Protect Against Acute Liver Injury Through the Production of Interleukin-6.
Gao RY, Wang M, Liu Q, Feng D, Wen Y, Xia Y, Colgan SP, Eltzschig HK, Ju C
Hepatology (Baltimore, Md.) 2020 Jun;71(6):2105-2117
Hepatology (Baltimore, Md.) 2020 Jun;71(6):2105-2117
Deregulated hypoxic response in myeloid cells: A model for high-altitude pulmonary oedema (HAPE).
Gojkovic M, Darmasaputra GS, Veliça P, Rundqvist H, Johnson RS
Acta physiologica (Oxford, England) 2020 Jun;229(2):e13461
Acta physiologica (Oxford, England) 2020 Jun;229(2):e13461
Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α.
Sun X, Sun BL, Babicheva A, Vanderpool R, Oita RC, Casanova N, Tang H, Gupta A, Lynn H, Gupta G, Rischard F, Sammani S, Kempf CL, Moreno-Vinasco L, Ahmed M, Camp SM, Wang J, Desai AA, Yuan JX, Garcia JGN
American journal of respiratory cell and molecular biology 2020 Jul;63(1):92-103
American journal of respiratory cell and molecular biology 2020 Jul;63(1):92-103
Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness.
Lu H, Xie Y, Tran L, Lan J, Yang Y, Murugan NL, Wang R, Wang YJ, Semenza GL
The Journal of clinical investigation 2020 Jul 27;
The Journal of clinical investigation 2020 Jul 27;
Hypoxia and transforming growth factor β1 regulation of long non-coding RNA transcriptomes in human pulmonary fibroblasts.
Senavirathna LK, Huang C, Pushparaj S, Xu D, Liu L
Physiological reports 2020 Jan;8(1):e14343
Physiological reports 2020 Jan;8(1):e14343
YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells.
Sivaraj KK, Dharmalingam B, Mohanakrishnan V, Jeong HW, Kato K, Schröder S, Adams S, Koh GY, Adams RH
eLife 2020 Jan 20;9
eLife 2020 Jan 20;9
Ex-Vivo Treatment of Tumor Tissue Slices as a Predictive Preclinical Method to Evaluate Targeted Therapies for Patients with Renal Carcinoma.
Roelants C, Pillet C, Franquet Q, Sarrazin C, Peilleron N, Giacosa S, Guyon L, Fontanell A, Fiard G, Long JA, Descotes JL, Cochet C, Filhol O
Cancers 2020 Jan 17;12(1)
Cancers 2020 Jan 17;12(1)
A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells.
Yoo HC, Park SJ, Nam M, Kang J, Kim K, Yeo JH, Kim JK, Heo Y, Lee HS, Lee MY, Lee CW, Kang JS, Kim YH, Lee J, Choi J, Hwang GS, Bang S, Han JM
Cell metabolism 2020 Feb 4;31(2):267-283.e12
Cell metabolism 2020 Feb 4;31(2):267-283.e12
Gamma-Aminobutyric Acid Increases Erythropoietin by Activation of Citrate Cycle and Stimulation of Hypoxia-Inducible Factors Expression in Rats.
Park KT, Han JK, Kim SJ, Lim YH
Biomolecules 2020 Apr 12;10(4)
Biomolecules 2020 Apr 12;10(4)
Hypoxia-Inducible Factor Inhibitors Derived from Marine Products Suppress a Murine Model of Neovascular Retinopathy.
Shoda C, Miwa Y, Nimura K, Okamoto K, Yamagami S, Tsubota K, Kurihara T
Nutrients 2020 Apr 10;12(4)
Nutrients 2020 Apr 10;12(4)
VEGFC acts as a double-edged sword in renal cell carcinoma aggressiveness.
Ndiaye PD, Dufies M, Giuliano S, Douguet L, Grépin R, Durivault J, Lenormand P, Glisse N, Mintcheva J, Vouret-Craviari V, Mograbi B, Wurmser M, Ambrosetti D, Rioux-Leclercq N, Maire P, Pagès G
Theranostics 2019;9(3):661-675
Theranostics 2019;9(3):661-675
Expression and role of HIF-1α and HIF-2α in tissue regeneration: a study of hypoxia in house gecko tail regeneration.
Novianti T, Juniantito V, Jusuf AA, Arida EA, Jusman SWA, Sadikin M
Organogenesis 2019;15(3):69-84
Organogenesis 2019;15(3):69-84
TRIB3 Promotes the Proliferation and Invasion of Renal Cell Carcinoma Cells via Activating MAPK Signaling Pathway.
Hong B, Zhou J, Ma K, Zhang J, Xie H, Zhang K, Li L, Cai L, Zhang N, Zhang Z, Gong K
International journal of biological sciences 2019;15(3):587-597
International journal of biological sciences 2019;15(3):587-597
Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma.
Sumi C, Matsuo Y, Kusunoki M, Shoji T, Uba T, Iwai T, Bono H, Hirota K
PloS one 2019;14(4):e0215072
PloS one 2019;14(4):e0215072
Hypoxia inhibits TNF-α-induced TSLP expression in keratinocytes.
Tashiro N, Segawa R, Tobita R, Asakawa S, Mizuno N, Hiratsuka M, Hirasawa N
PloS one 2019;14(11):e0224705
PloS one 2019;14(11):e0224705
The prognostic value of hypoxia-inducible factor-1α in advanced cancer survivors: a meta-analysis with trial sequential analysis.
Han S, Huang T, Hou F, Yao L, Wang X, Wu X
Therapeutic advances in medical oncology 2019;11:1758835919875851
Therapeutic advances in medical oncology 2019;11:1758835919875851
Involvement of A3 Adenosine Receptor in Neuroblastoma Progression via Modulation of the Hypoxic/Angiogenic Pathway.
Maugeri G, D'Amico AG, Federico C, Saccone S, Giunta S, Cavallaro S, D'Agata V
Journal of molecular neuroscience : MN 2019 Sep;69(1):166-176
Journal of molecular neuroscience : MN 2019 Sep;69(1):166-176
Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis.
Choi SA, Kim YH, Park YH, Yang HJ, Jeong PS, Cha JJ, Yoon SB, Kim JS, Song BS, Lee JH, Sim BW, Huh JW, Song IS, Lee SR, Kim MK, Kim JM, Bae YS, Imakawa K, Kim SU, Chang KT
Cell death and differentiation 2019 Sep;26(9):1582-1599
Cell death and differentiation 2019 Sep;26(9):1582-1599
A genetic mouse model of severe iron deficiency anemia reveals tissue-specific transcriptional stress responses and cardiac remodeling.
Schwartz AJ, Converso-Baran K, Michele DE, Shah YM
The Journal of biological chemistry 2019 Oct 11;294(41):14991-15002
The Journal of biological chemistry 2019 Oct 11;294(41):14991-15002
Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism.
Zhang X, Zhang Y, Wang P, Zhang SY, Dong Y, Zeng G, Yan Y, Sun L, Wu Q, Liu H, Liu B, Kong W, Wang X, Jiang C
Cell metabolism 2019 Nov 5;30(5):937-951.e5
Cell metabolism 2019 Nov 5;30(5):937-951.e5
The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension.
Morikawa M, Mitani Y, Holmborn K, Kato T, Koinuma D, Maruyama J, Vasilaki E, Sawada H, Kobayashi M, Ozawa T, Morishita Y, Bessho Y, Maeda S, Ledin J, Aburatani H, Kageyama R, Maruyama K, Heldin CH, Miyazono K
Science signaling 2019 Nov 12;12(607)
Science signaling 2019 Nov 12;12(607)
Tumor infiltrating mast cells determine oncogenic HIF-2α-conferred immune evasion in clear cell renal cell carcinoma.
Xiong Y, Liu L, Xia Y, Qi Y, Chen Y, Chen L, Zhang P, Kong Y, Qu Y, Wang Z, Lin Z, Chen X, Xiang Z, Wang J, Bai Q, Zhang W, Yang Y, Guo J, Xu J
Cancer immunology, immunotherapy : CII 2019 May;68(5):731-741
Cancer immunology, immunotherapy : CII 2019 May;68(5):731-741
Astrocytic cystine/glutamate antiporter is a key regulator of erythropoietin expression in the ischemic retina.
Lee BJ, Jun HO, Kim JH, Kim JH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):6045-6054
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):6045-6054
Sox17 is required for endothelial regeneration following inflammation-induced vascular injury.
Liu M, Zhang L, Marsboom G, Jambusaria A, Xiong S, Toth PT, Benevolenskaya EV, Rehman J, Malik AB
Nature communications 2019 May 9;10(1):2126
Nature communications 2019 May 9;10(1):2126
A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension.
Dabral S, Muecke C, Valasarajan C, Schmoranzer M, Wietelmann A, Semenza GL, Meister M, Muley T, Seeger-Nukpezah T, Samakovlis C, Weissmann N, Grimminger F, Seeger W, Savai R, Pullamsetti SS
Nature communications 2019 May 13;10(1):2130
Nature communications 2019 May 13;10(1):2130
Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer.
Fujimoto TN, Colbert LE, Huang Y, Molkentine JM, Deorukhkar A, Baseler L, de la Cruz Bonilla M, Yu M, Lin D, Gupta S, Cabeceiras PK, Kingsley CV, Tailor RC, Sawakuchi GO, Koay EJ, Piwnica-Worms H, Maitra A, Taniguchi CM
Cancer research 2019 May 1;79(9):2327-2338
Cancer research 2019 May 1;79(9):2327-2338
Collagen Remodeling in the Hypoxic Tumor-Mesothelial Niche Promotes Ovarian Cancer Metastasis.
Natarajan S, Foreman KM, Soriano MI, Rossen NS, Shehade H, Fregoso DR, Eggold JT, Krishnan V, Dorigo O, Krieg AJ, Heilshorn SC, Sinha S, Fuh KC, Rankin EB
Cancer research 2019 May 1;79(9):2271-2284
Cancer research 2019 May 1;79(9):2271-2284
Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway.
Chang SH, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, Taniguchi Y, Sugita S, Yano F, Chung UI, Kim-Kaneyama JR, Yanagita M, Economides A, Canalis E, Chen D, Tanaka S, Saito T
Nature communications 2019 Mar 29;10(1):1442
Nature communications 2019 Mar 29;10(1):1442
SMAD family member 3 (SMAD3) and SMAD4 repress HIF2α-dependent iron-regulatory genes.
Ma X, Das NK, Castillo C, Gourani A, Perekatt AO, Verzi MP, Shah YM
The Journal of biological chemistry 2019 Mar 15;294(11):3974-3986
The Journal of biological chemistry 2019 Mar 15;294(11):3974-3986
A KLF6-driven transcriptional network links lipid homeostasis and tumour growth in renal carcinoma.
Syafruddin SE, Rodrigues P, Vojtasova E, Patel SA, Zaini MN, Burge J, Warren AY, Stewart GD, Eisen T, Bihary D, Samarajiwa SA, Vanharanta S
Nature communications 2019 Mar 11;10(1):1152
Nature communications 2019 Mar 11;10(1):1152
Hypoxia-induced Changes in SUMO Conjugation Affect Transcriptional Regulation Under Low Oxygen.
Chachami G, Stankovic-Valentin N, Karagiota A, Basagianni A, Plessmann U, Urlaub H, Melchior F, Simos G
Molecular & cellular proteomics : MCP 2019 Jun;18(6):1197-1209
Molecular & cellular proteomics : MCP 2019 Jun;18(6):1197-1209
Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.
Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K, Cheng X, Cawthorne E, Coleman ML, Crockford TL, Davies B, Dow LE, Goldin R, Kranc K, Kudo H, Lawson H, McAuliffe J, Milward K, Scudamore CL, Soilleux E, Issa F, Ratcliffe PJ, Pugh CW
The Journal of clinical investigation 2019 Jun 4;129(9):3640-3656
The Journal of clinical investigation 2019 Jun 4;129(9):3640-3656
Dysregulated expression of hypoxia-inducible factors augments myofibroblasts differentiation in idiopathic pulmonary fibrosis.
Aquino-Gálvez A, González-Ávila G, Jiménez-Sánchez LL, Maldonado-Martínez HA, Cisneros J, Toscano-Marquez F, Castillejos-López M, Torres-Espíndola LM, Velázquez-Cruz R, Rodríguez VHO, Flores-Soto E, Solís-Chagoyán H, Cabello C, Zúñiga J, Romero Y
Respiratory research 2019 Jun 24;20(1):130
Respiratory research 2019 Jun 24;20(1):130
Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation.
Lee YS, Riopel M, Cabrales P, Bandyopadhyay GK
Science advances 2019 Jul;5(7):eaaw4176
Science advances 2019 Jul;5(7):eaaw4176
NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms.
Santana-Codina N, Gableske S, Quiles del Rey M, Małachowska B, Jedrychowski MP, Biancur DE, Schmidt PJ, Fleming MD, Fendler W, Harper JW, Kimmelman AC, Mancias JD
Haematologica 2019 Jul;104(7):1342-1354
Haematologica 2019 Jul;104(7):1342-1354
Putative Role of Nuclear Factor-Kappa B But Not Hypoxia-Inducible Factor-1α in Hypoxia-Dependent Regulation of Oxidative Stress in Hematopoietic Stem and Progenitor Cells.
Halvarsson C, Rörby E, Eliasson P, Lang S, Soneji S, Jönsson JI
Antioxidants & redox signaling 2019 Jul 20;31(3):211-226
Antioxidants & redox signaling 2019 Jul 20;31(3):211-226
Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment.
Qi D, Wei M, Jiao S, Song Y, Wang X, Xie G, Taranto J, Liu Y, Duan Y, Yu B, Li H, Shah YM, Xu Q, Du J, Gonzalez FJ, Qu A
Cell death & disease 2019 Jul 18;10(8):544
Cell death & disease 2019 Jul 18;10(8):544
Hypoxic Environment Promotes Barrier Formation in Human Intestinal Epithelial Cells through Regulation of MicroRNA 320a Expression.
Muenchau S, Deutsch R, de Castro IJ, Hielscher T, Heber N, Niesler B, Lusic M, Stanifer ML, Boulant S
Molecular and cellular biology 2019 Jul 15;39(14)
Molecular and cellular biology 2019 Jul 15;39(14)
Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity.
Seo JB, Riopel M, Cabrales P, Huh JY, Bandyopadhyay GK, Andreyev AY, Murphy AN, Beeman SC, Smith GI, Klein S, Lee YS, Olefsky JM
Nature metabolism 2019 Jan;1(1):86-97
Nature metabolism 2019 Jan;1(1):86-97
HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer.
Jarman EJ, Ward C, Turnbull AK, Martinez-Perez C, Meehan J, Xintaropoulou C, Sims AH, Langdon SP
Breast cancer research : BCR 2019 Jan 22;21(1):10
Breast cancer research : BCR 2019 Jan 22;21(1):10
Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload.
Schwartz AJ, Das NK, Ramakrishnan SK, Jain C, Jurkovic MT, Wu J, Nemeth E, Lakhal-Littleton S, Colacino JA, Shah YM
The Journal of clinical investigation 2019 Jan 2;129(1):336-348
The Journal of clinical investigation 2019 Jan 2;129(1):336-348
ONECUT2 is a driver of neuroendocrine prostate cancer.
Guo H, Ci X, Ahmed M, Hua JT, Soares F, Lin D, Puca L, Vosoughi A, Xue H, Li E, Su P, Chen S, Nguyen T, Liang Y, Zhang Y, Xu X, Xu J, Sheahan AV, Ba-Alawi W, Zhang S, Mahamud O, Vellanki RN, Gleave M, Bristow RG, Haibe-Kains B, Poirier JT, Rudin CM, Tsao MS, Wouters BG, Fazli L, Feng FY, Ellis L, van der Kwast T, Berlin A, Koritzinsky M, Boutros PC, Zoubeidi A, Beltran H, Wang Y, He HH
Nature communications 2019 Jan 17;10(1):278
Nature communications 2019 Jan 17;10(1):278
HIF-1α-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia.
Karagiota A, Kourti M, Simos G, Mylonis I
Cellular and molecular life sciences : CMLS 2019 Feb;76(4):809-825
Cellular and molecular life sciences : CMLS 2019 Feb;76(4):809-825
Hypoxia-inducible factor: role in cell survival in superoxide dismutase overexpressing mice after neonatal hypoxia-ischemia.
Jeon GW, Sheldon RA, Ferriero DM
Korean journal of pediatrics 2019 Dec;62(12):444-449
Korean journal of pediatrics 2019 Dec;62(12):444-449
Platelet HIF-2α promotes thrombogenicity through PAI-1 synthesis and extracellular vesicle release.
Chaurasia SN, Kushwaha G, Kulkarni PP, Mallick RL, Latheef NA, Mishra JK, Dash D
Haematologica 2019 Dec;104(12):2482-2492
Haematologica 2019 Dec;104(12):2482-2492
SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors -1α and -2α in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets.
Cannito S, Foglia B, Villano G, Turato C, Delgado TC, Morello E, Pin F, Novo E, Napione L, Quarta S, Ruvoletto M, Fasolato S, Zanus G, Colombatto S, Lopitz-Otsoa F, Fernández-Ramos D, Bussolino F, Sutti S, Albano E, Martínez-Chantar ML, Pontisso P, Parola M
Cancers 2019 Dec 4;11(12)
Cancers 2019 Dec 4;11(12)
Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk.
Hart PC, Kenny HA, Grassl N, Watters KM, Litchfield LM, Coscia F, Blaženović I, Ploetzky L, Fiehn O, Mann M, Lengyel E, Romero IL
Cell reports 2019 Dec 17;29(12):4086-4098.e6
Cell reports 2019 Dec 17;29(12):4086-4098.e6
Differential regulation of estrogen in iron metabolism in astrocytes and neurons.
Xu M, Tan X, Li N, Wu H, Wang Y, Xie J, Wang J
Journal of cellular physiology 2019 Apr;234(4):4232-4242
Journal of cellular physiology 2019 Apr;234(4):4232-4242
Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease.
Laitakari A, Ollonen T, Kietzmann T, Walkinshaw G, Mennerich D, Izzi V, Haapasaari KM, Myllyharju J, Serpi R, Dimova EY, Koivunen P
Redox biology 2019 Apr;22:101145
Redox biology 2019 Apr;22:101145
Histone H3K9 demethylase JMJD1A is a co-activator of erythropoietin expression under hypoxia.
Tian Z, Yao L, Shen Y, Guo X, Duan X
The international journal of biochemistry & cell biology 2019 Apr;109:33-39
The international journal of biochemistry & cell biology 2019 Apr;109:33-39
Glycolysis Regulates Human Embryonic Stem Cell Self-Renewal under Hypoxia through HIF-2α and the Glycolytic Sensors CTBPs.
Arthur SA, Blaydes JP, Houghton FD
Stem cell reports 2019 Apr 9;12(4):728-742
Stem cell reports 2019 Apr 9;12(4):728-742
ERK1/2 phosphorylates HIF-2α and regulates its activity by controlling its CRM1-dependent nuclear shuttling.
Gkotinakou IM, Befani C, Simos G, Liakos P
Journal of cell science 2019 Apr 8;132(7)
Journal of cell science 2019 Apr 8;132(7)
Impact of Extrinsic and Intrinsic Hypoxia on Catecholamine Biosynthesis in Absence or Presence of Hif2α in Pheochromocytoma Cells.
Bechmann N, Poser I, Seifert V, Greunke C, Ullrich M, Qin N, Walch A, Peitzsch M, Robledo M, Pacak K, Pietzsch J, Richter S, Eisenhofer G
Cancers 2019 Apr 28;11(5)
Cancers 2019 Apr 28;11(5)
Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm.
Schofield HK, Tandon M, Park MJ, Halbrook CJ, Ramakrishnan SK, Kim EC, Shi J, Omary MB, Shah YM, Esni F, Pasca di Magliano M
Cellular and molecular gastroenterology and hepatology 2018;5(2):169-185.e2
Cellular and molecular gastroenterology and hepatology 2018;5(2):169-185.e2
Glucocorticoid Impaired the Wound Healing Ability of Endothelial Progenitor Cells by Reducing the Expression of CXCR4 in the PGE2 Pathway.
Carolina E, Kato T, Khanh VC, Moriguchi K, Yamashita T, Takeuchi K, Hamada H, Ohneda O
Frontiers in medicine 2018;5:276
Frontiers in medicine 2018;5:276
Hypoxic stabilization of mRNA is HIF-independent but requires mtROS.
Fortenbery GW, Sarathy B, Carraway KR, Mansfield KD
Cellular & molecular biology letters 2018;23:48
Cellular & molecular biology letters 2018;23:48
Immunohistochemistry of the circadian clock in mouse and human vascular tissues.
Anea CB, Merloiu AM, Fulton DJR, Patel V, Rudic RD
Vessel plus 2018;2
Vessel plus 2018;2
Chromatin Immunoprecipitation of HIF-α in Breast Tumor Cells Using Wild Type and Loss of Function Models.
Brooks DL, Seagroves TN
Methods in molecular biology (Clifton, N.J.) 2018;1742:67-79
Methods in molecular biology (Clifton, N.J.) 2018;1742:67-79
Analysis of Hypoxia and the Hypoxic Response in Tumor Xenografts.
Böğürcü N, Seidel S, Garvalov BK, Acker T
Methods in molecular biology (Clifton, N.J.) 2018;1742:283-300
Methods in molecular biology (Clifton, N.J.) 2018;1742:283-300
The hypoxia inducible factor/erythropoietin (EPO)/EPO receptor pathway is disturbed in a rat model of chronic kidney disease related anemia.
Landau D, London L, Bandach I, Segev Y
PloS one 2018;13(5):e0196684
PloS one 2018;13(5):e0196684
Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1α activation.
Ferecatu I, Canal F, Fabbri L, Mazure NM, Bouton C, Golinelli-Cohen MP
PloS one 2018;13(3):e0194782
PloS one 2018;13(3):e0194782
The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma.
Ambrosetti D, Dufies M, Dadone B, Durand M, Borchiellini D, Amiel J, Pouyssegur J, Rioux-Leclercq N, Pages G, Burel-Vandenbos F, Mazure NM
PloS one 2018;13(2):e0193477
PloS one 2018;13(2):e0193477
The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma.
Miess H, Dankworth B, Gouw AM, Rosenfeldt M, Schmitz W, Jiang M, Saunders B, Howell M, Downward J, Felsher DW, Peck B, Schulze A
Oncogene 2018 Oct;37(40):5435-5450
Oncogene 2018 Oct;37(40):5435-5450
Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen.
Deygas M, Gadet R, Gillet G, Rimokh R, Gonzalo P, Mikaelian I
Nature communications 2018 Oct 31;9(1):4545
Nature communications 2018 Oct 31;9(1):4545
Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer.
Liao L, Liu ZZ, Langbein L, Cai W, Cho EA, Na J, Niu X, Jiang W, Zhong Z, Cai WL, Jagannathan G, Dulaimi E, Testa JR, Uzzo RG, Wang Y, Stark GR, Sun J, Peiper S, Xu Y, Yan Q, Yang H
eLife 2018 Oct 25;7
eLife 2018 Oct 25;7
BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion.
Sethuraman A, Brown M, Krutilina R, Wu ZH, Seagroves TN, Pfeffer LM, Fan M
Breast cancer research : BCR 2018 Oct 1;20(1):117
Breast cancer research : BCR 2018 Oct 1;20(1):117
Intra-tumoral treatment with oxygen-ozone in glioblastoma: A systematic literature search and results of a case series.
Megele R, Riemenschneider MJ, Dodoo-Schittko F, Feyrer M, Kleindienst A
Oncology letters 2018 Nov;16(5):5813-5822
Oncology letters 2018 Nov;16(5):5813-5822
Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis.
Regan Anderson TM, Ma S, Perez Kerkvliet C, Peng Y, Helle TM, Krutilina RI, Raj GV, Cidlowski JA, Ostrander JH, Schwertfeger KL, Seagroves TN, Lange CA
Molecular cancer research : MCR 2018 Nov;16(11):1761-1772
Molecular cancer research : MCR 2018 Nov;16(11):1761-1772
Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis.
Murahashi Y, Yano F, Kobayashi H, Makii Y, Iba K, Yamashita T, Tanaka S, Saito T
Scientific reports 2018 Nov 7;8(1):16475
Scientific reports 2018 Nov 7;8(1):16475
HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia.
Abdul-Aziz AM, Shafat MS, Sun Y, Marlein CR, Piddock RE, Robinson SD, Edwards DR, Zhou Z, Collins A, Bowles KM, Rushworth SA
Oncogene 2018 May;37(20):2676-2686
Oncogene 2018 May;37(20):2676-2686
The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells.
Kim H, Lin Q, Glazer PM, Yun Z
Breast cancer research : BCR 2018 Mar 6;20(1):16
Breast cancer research : BCR 2018 Mar 6;20(1):16
PACAP and VIP regulate hypoxia-inducible factors in neuroblastoma cells exposed to hypoxia.
Maugeri G, D'Amico AG, Rasà DM, Saccone S, Federico C, Cavallaro S, D'Agata V
Neuropeptides 2018 Jun;69:84-91
Neuropeptides 2018 Jun;69:84-91
Transient HIF2A inhibition promotes satellite cell proliferation and muscle regeneration.
Xie L, Yin A, Nichenko AS, Beedle AM, Call JA, Yin H
The Journal of clinical investigation 2018 Jun 1;128(6):2339-2355
The Journal of clinical investigation 2018 Jun 1;128(6):2339-2355
Hypoxia Upregulates Estrogen Receptor β in Pulmonary Artery Endothelial Cells in a HIF-1α-Dependent Manner.
Frump AL, Selej M, Wood JA, Albrecht M, Yakubov B, Petrache I, Lahm T
American journal of respiratory cell and molecular biology 2018 Jul;59(1):114-126
American journal of respiratory cell and molecular biology 2018 Jul;59(1):114-126
PEGylated IL-11 (BBT-059): A Novel Radiation Countermeasure for Hematopoietic Acute Radiation Syndrome.
Kumar VP, Biswas S, Sharma NK, Stone S, Fam CM, Cox GN, Ghosh SP
Health physics 2018 Jul;115(1):65-76
Health physics 2018 Jul;115(1):65-76
Enhancement of glycolysis by inhibition of oxygen-sensing prolyl hydroxylases protects alveolar epithelial cells from acute lung injury.
Tojo K, Tamada N, Nagamine Y, Yazawa T, Ota S, Goto T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jan 5;:fj201700888R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jan 5;:fj201700888R
Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation.
Maybin JA, Murray AA, Saunders PTK, Hirani N, Carmeliet P, Critchley HOD
Nature communications 2018 Jan 23;9(1):295
Nature communications 2018 Jan 23;9(1):295
Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B.
Ho JJD, Balukoff NC, Cervantes G, Malcolm PD, Krieger JR, Lee S
Cell reports 2018 Jan 2;22(1):17-26
Cell reports 2018 Jan 2;22(1):17-26
Hypoxia-Inducible PIM Kinase Expression Promotes Resistance to Antiangiogenic Agents.
Casillas AL, Toth RK, Sainz AG, Singh N, Desai AA, Kraft AS, Warfel NA
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Jan 1;24(1):169-180
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Jan 1;24(1):169-180
Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling.
Senavirathna LK, Huang C, Yang X, Munteanu MC, Sathiaseelan R, Xu D, Henke CA, Liu L
Scientific reports 2018 Feb 9;8(1):2709
Scientific reports 2018 Feb 9;8(1):2709
SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α.
Mira E, Carmona-Rodríguez L, Pérez-Villamil B, Casas J, Fernández-Aceñero MJ, Martínez-Rey D, Martín-González P, Heras-Murillo I, Paz-Cabezas M, Tardáguila M, Oury TD, Martín-Puig S, Lacalle RA, Fabriás G, Díaz-Rubio E, Mañes S
Nature communications 2018 Feb 8;9(1):575
Nature communications 2018 Feb 8;9(1):575
Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells.
Samanta D, Park Y, Ni X, Li H, Zahnow CA, Gabrielson E, Pan F, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2018 Feb 6;115(6):E1239-E1248
Proceedings of the National Academy of Sciences of the United States of America 2018 Feb 6;115(6):E1239-E1248
Consequences of VHL Loss on Global DNA Methylome.
Robinson CM, Lefebvre F, Poon BP, Bousard A, Fan X, Lathrop M, Tost J, Kim WY, Riazalhosseini Y, Ohh M
Scientific reports 2018 Feb 20;8(1):3313
Scientific reports 2018 Feb 20;8(1):3313
Endothelial HIF-2α contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition.
Tang H, Babicheva A, McDermott KM, Gu Y, Ayon RJ, Song S, Wang Z, Gupta A, Zhou T, Sun X, Dash S, Wang Z, Balistrieri A, Zheng Q, Cordery AG, Desai AA, Rischard F, Khalpey Z, Wang J, Black SM, Garcia JGN, Makino A, Yuan JX
American journal of physiology. Lung cellular and molecular physiology 2018 Feb 1;314(2):L256-L275
American journal of physiology. Lung cellular and molecular physiology 2018 Feb 1;314(2):L256-L275
Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer.
Olcina MM, Balanis NG, Kim RK, Aksoy BA, Kodysh J, Thompson MJ, Hammerbacher J, Graeber TG, Giaccia AJ
Cell reports 2018 Dec 26;25(13):3721-3732.e6
Cell reports 2018 Dec 26;25(13):3721-3732.e6
Targeting the Mevalonate Pathway Suppresses VHL-Deficient CC-RCC through an HIF-Dependent Mechanism.
Thompson JM, Alvarez A, Singha MK, Pavesic MW, Nguyen QH, Nelson LJ, Fruman DA, Razorenova OV
Molecular cancer therapeutics 2018 Aug;17(8):1781-1792
Molecular cancer therapeutics 2018 Aug;17(8):1781-1792
Endogenous HIF2A reporter systems for high-throughput functional screening.
Zaini MN, Patel SA, Syafruddin SE, Rodrigues P, Vanharanta S
Scientific reports 2018 Aug 13;8(1):12063
Scientific reports 2018 Aug 13;8(1):12063
Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Protein (TIP30).
Yang Q, Guo X, Yang L
Medical science monitor : international medical journal of experimental and clinical research 2018 Apr 14;24:2225-2234
Medical science monitor : international medical journal of experimental and clinical research 2018 Apr 14;24:2225-2234
PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα.
Dopeso H, Jiao HK, Cuesta AM, Henze AT, Jurida L, Kracht M, Acker-Palmer A, Garvalov BK, Acker T
Cancer research 2018 Apr 1;78(7):1805-1819
Cancer research 2018 Apr 1;78(7):1805-1819
Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: a "U-shaped" relationship.
Shi M, Flores B, Li P, Gillings N, McMillan KL, Ye J, Huang LJ, Sidhu SS, Zhong YP, Grompe MT, Streeter PR, Moe OW, Hu MC
American journal of physiology. Renal physiology 2018 Apr 1;314(4):F501-F516
American journal of physiology. Renal physiology 2018 Apr 1;314(4):F501-F516
A Crucial Role of CXCL14 for Promoting Regulatory T Cells Activation in Stroke.
Lee HT, Liu SP, Lin CH, Lee SW, Hsu CY, Sytwu HK, Hsieh CH, Shyu WC
Theranostics 2017;7(4):855-875
Theranostics 2017;7(4):855-875
Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis.
Bäcker V, Cheung FY, Siveke JT, Fandrey J, Winning S
PloS one 2017;12(12):e0190074
PloS one 2017;12(12):e0190074
Restoration of the prolyl-hydroxylase domain protein-3 oxygen-sensing mechanism is responsible for regulation of HIF2α expression and induction of sensitivity of myeloma cells to hypoxia-mediated apoptosis.
Gastelum G, Poteshkina A, Veena M, Artiga E, Weckstein G, Frost P
PloS one 2017;12(12):e0188438
PloS one 2017;12(12):e0188438
Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway.
Ho JC, Abdullah LN, Pang QY, Jha S, Chow EK, Yang H, Kato H, Poellinger L, Ueda J, Lee KL
PloS one 2017;12(11):e0188051
PloS one 2017;12(11):e0188051
Ablation of endothelial prolyl hydroxylase domain protein-2 promotes renal vascular remodelling and fibrosis in mice.
Wang S, Zeng H, Chen ST, Zhou L, Xie XJ, He X, Tao YK, Tuo QH, Deng C, Liao DF, Chen JX
Journal of cellular and molecular medicine 2017 Sep;21(9):1967-1978
Journal of cellular and molecular medicine 2017 Sep;21(9):1967-1978
The pVHL172 isoform is not a tumor suppressor and up-regulates a subset of pro-tumorigenic genes including TGFB1 and MMP13.
Hascoet P, Chesnel F, Jouan F, Le Goff C, Couturier A, Darrigrand E, Mahe F, Rioux-Leclercq N, Le Goff X, Arlot-Bonnemains Y
Oncotarget 2017 Sep 29;8(44):75989-76002
Oncotarget 2017 Sep 29;8(44):75989-76002
Histone methylase MLL1 coordinates with HIF and regulate lncRNA HOTAIR expression under hypoxia.
Bhan A, Deb P, Shihabeddin N, Ansari KI, Brotto M, Mandal SS
Gene 2017 Sep 20;629:16-28
Gene 2017 Sep 20;629:16-28
Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis.
Liu Z, Yan S, Wang J, Xu Y, Wang Y, Zhang S, Xu X, Yang Q, Zeng X, Zhou Y, Gu X, Lu S, Fu Z, Fulton DJ, Weintraub NL, Caldwell RB, Zhang W, Wu C, Liu XL, Chen JF, Ahmad A, Kaddour-Djebbar I, Al-Shabrawey M, Li Q, Jiang X, Sun Y, Sodhi A, Smith L, Hong M, Huo Y
Nature communications 2017 Sep 19;8(1):584
Nature communications 2017 Sep 19;8(1):584
Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1α.
Tsang KM, Hyun JS, Cheng KT, Vargas M, Mehta D, Ushio-Fukai M, Zou L, Pajcini KV, Rehman J, Malik AB
Stem cell reports 2017 Sep 12;9(3):796-806
Stem cell reports 2017 Sep 12;9(3):796-806
Selective tubular activation of hypoxia-inducible factor-2α has dual effects on renal fibrosis.
Kong KH, Oh HJ, Lim BJ, Kim M, Han KH, Choi YH, Kwon K, Nam BY, Park KS, Park JT, Han SH, Yoo TH, Lee S, Kim SJ, Kang DH, Choi KB, Eremina V, Quaggin SE, Ryu DR, Kang SW
Scientific reports 2017 Sep 12;7(1):11351
Scientific reports 2017 Sep 12;7(1):11351
KDM4A regulates HIF-1 levels through H3K9me3.
Dobrynin G, McAllister TE, Leszczynska KB, Ramachandran S, Krieg AJ, Kawamura A, Hammond EM
Scientific reports 2017 Sep 11;7(1):11094
Scientific reports 2017 Sep 11;7(1):11094
The prognosis outcome of oral squamous cell carcinoma using HIF-2α.
Lim E, Kuo CC, Tu HF, Yang CC
Journal of the Chinese Medical Association : JCMA 2017 Oct;80(10):651-656
Journal of the Chinese Medical Association : JCMA 2017 Oct;80(10):651-656
Trophoblast survival signaling during human placentation requires HSP70 activation of MMP2-mediated HBEGF shedding.
Jain CV, Jessmon P, Barrak CT, Bolnick AD, Kilburn BA, Hertz M, Armant DR
Cell death and differentiation 2017 Oct;24(10):1772-1783
Cell death and differentiation 2017 Oct;24(10):1772-1783
Hypoxia favors myosin heavy chain beta gene expression in an Hif-1alpha-dependent manner.
Binó L, Procházková J, Radaszkiewicz KA, Kučera J, Kudová J, Pacherník J, Kubala L
Oncotarget 2017 Oct 13;8(48):83684-83697
Oncotarget 2017 Oct 13;8(48):83684-83697
Pharmacological HIF-inhibition attenuates postoperative adhesion formation.
Strowitzki MJ, Ritter AS, Radhakrishnan P, Harnoss JM, Opitz VM, Biller M, Wehrmann J, Keppler U, Scheer J, Wallwiener M, Schmidt T, Ulrich A, Schneider M
Scientific reports 2017 Oct 13;7(1):13151
Scientific reports 2017 Oct 13;7(1):13151
Hypoxia-inducible factor 2α (HIF-2α) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity.
Ma X, Zhang H, Xue X, Shah YM
The Journal of biological chemistry 2017 Oct 13;292(41):17046-17056
The Journal of biological chemistry 2017 Oct 13;292(41):17046-17056
VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.
Yao X, Tan J, Lim KJ, Koh J, Ooi WF, Li Z, Huang D, Xing M, Chan YS, Qu JZ, Tay ST, Wijaya G, Lam YN, Hong JH, Lee-Lim AP, Guan P, Ng MSW, He CZ, Lin JS, Nandi T, Qamra A, Xu C, Myint SS, Davies JOJ, Goh JY, Loh G, Tan BC, Rozen SG, Yu Q, Tan IBH, Cheng CWS, Li S, Chang KTE, Tan PH, Silver DL, Lezhava A, Steger G, Hughes JR, Teh BT, Tan P
Cancer discovery 2017 Nov;7(11):1284-1305
Cancer discovery 2017 Nov;7(11):1284-1305
Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis.
Xie C, Yagai T, Luo Y, Liang X, Chen T, Wang Q, Sun D, Zhao J, Ramakrishnan SK, Sun L, Jiang C, Xue X, Tian Y, Krausz KW, Patterson AD, Shah YM, Wu Y, Jiang C, Gonzalez FJ
Nature medicine 2017 Nov;23(11):1298-1308
Nature medicine 2017 Nov;23(11):1298-1308
Endothelial specific SIRT3 deletion impairs glycolysis and angiogenesis and causes diastolic dysfunction.
He X, Zeng H, Chen ST, Roman RJ, Aschner JL, Didion S, Chen JX
Journal of molecular and cellular cardiology 2017 Nov;112:104-113
Journal of molecular and cellular cardiology 2017 Nov;112:104-113
Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress.
Fanelli G, Gonzalez-Cordero A, Gardner PJ, Peng Q, Fernando M, Kloc M, Farrar CA, Naeem A, Garred P, Ali RR, Sacks SH
Scientific reports 2017 Nov 7;7(1):14625
Scientific reports 2017 Nov 7;7(1):14625
HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism.
Du W, Zhang L, Brett-Morris A, Aguila B, Kerner J, Hoppel CL, Puchowicz M, Serra D, Herrero L, Rini BI, Campbell S, Welford SM
Nature communications 2017 Nov 24;8(1):1769
Nature communications 2017 Nov 24;8(1):1769
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
Palazon A, Tyrakis PA, Macias D, Veliça P, Rundqvist H, Fitzpatrick S, Vojnovic N, Phan AT, Loman N, Hedenfalk I, Hatschek T, Lövrot J, Foukakis T, Goldrath AW, Bergh J, Johnson RS
Cancer cell 2017 Nov 13;32(5):669-683.e5
Cancer cell 2017 Nov 13;32(5):669-683.e5
Activation of the hypoxia-inducible factor pathway induced by prolyl hydroxylase domain 2 deficiency enhances the effect of running training in mice.
Nunomiya A, Shin J, Kitajima Y, Dan T, Miyata T, Nagatomi R
Acta physiologica (Oxford, England) 2017 May;220(1):99-112
Acta physiologica (Oxford, England) 2017 May;220(1):99-112
HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium.
Wu D, Huang RT, Hamanaka RB, Krause M, Oh MJ, Kuo CH, Nigdelioglu R, Meliton AY, Witt L, Dai G, Civelek M, Prabhakar NR, Fang Y, Mutlu GM
eLife 2017 May 30;6
eLife 2017 May 30;6
Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells.
Yasui T, Uezono N, Nakashima H, Noguchi H, Matsuda T, Noda-Andoh T, Okano H, Nakashima K
Stem cell reports 2017 Jun 6;8(6):1743-1756
Stem cell reports 2017 Jun 6;8(6):1743-1756
HIF-2α dictates the susceptibility of pancreatic cancer cells to TRAIL by regulating survivin expression.
Harashima N, Takenaga K, Akimoto M, Harada M
Oncotarget 2017 Jun 27;8(26):42887-42900
Oncotarget 2017 Jun 27;8(26):42887-42900
Downregulation of PCK2 remodels tricarboxylic acid cycle in tumor-repopulating cells of melanoma.
Luo S, Li Y, Ma R, Liu J, Xu P, Zhang H, Tang K, Ma J, Liu N, Zhang Y, Sun Y, Ji T, Liang X, Yin X, Liu Y, Tong W, Niu Y, Wang N, Wang X, Huang B
Oncogene 2017 Jun 22;36(25):3609-3617
Oncogene 2017 Jun 22;36(25):3609-3617
HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death.
Okamoto A, Sumi C, Tanaka H, Kusunoki M, Iwai T, Nishi K, Matsuo Y, Harada H, Takenaga K, Bono H, Hirota K
Scientific reports 2017 Jun 19;7(1):3816
Scientific reports 2017 Jun 19;7(1):3816
Decreased expression of acetyl-CoA synthase 2 promotes metastasis and predicts poor prognosis in hepatocellular carcinoma.
Sun L, Kong Y, Cao M, Zhou H, Li H, Cui Y, Fang F, Zhang W, Li J, Zhu X, Li Q, Song T, Zhang T
Cancer science 2017 Jul;108(7):1338-1346
Cancer science 2017 Jul;108(7):1338-1346
Deregulated expression of miR-29a-3p, miR-494-3p and miR-660-5p affects sensitivity to tyrosine kinase inhibitors in CML leukemic stem cells.
Salati S, Salvestrini V, Carretta C, Genovese E, Rontauroli S, Zini R, Rossi C, Ruberti S, Bianchi E, Barbieri G, Curti A, Castagnetti F, Gugliotta G, Rosti G, Bergamaschi M, Tafuri A, Tagliafico E, Lemoli R, Manfredini R
Oncotarget 2017 Jul 25;8(30):49451-49469
Oncotarget 2017 Jul 25;8(30):49451-49469
Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations.
Ke S, Chen S, Dong Z, Hong CS, Zhang Q, Tang L, Yang P, Zhai J, Yan H, Shen F, Zhuang Z, Wen W, Wang H
Hepatology (Baltimore, Md.) 2017 Jan;65(1):134-151
Hepatology (Baltimore, Md.) 2017 Jan;65(1):134-151
The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction.
Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M, Fukui Y
Nature communications 2017 Jan 9;8:13946
Nature communications 2017 Jan 9;8:13946
Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye.
Gardner PJ, Liyanage SE, Cristante E, Sampson RD, Dick AD, Ali RR, Bainbridge JW
Scientific reports 2017 Jan 23;7:40830
Scientific reports 2017 Jan 23;7:40830
Stable knockdown of CREB, HIF-1 and HIF-2 by replication-competent retroviruses abrogates the responses to hypoxia in hepatocellular carcinoma.
Shneor D, Folberg R, Pe'er J, Honigman A, Frenkel S
Cancer gene therapy 2017 Feb;24(2):64-74
Cancer gene therapy 2017 Feb;24(2):64-74
Hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) is a direct regulator of epidermal growth factor receptor (EGFR) signaling in breast cancer.
Kozlova N, Wottawa M, Katschinski DM, Kristiansen G, Kietzmann T
Oncotarget 2017 Feb 7;8(6):9885-9898
Oncotarget 2017 Feb 7;8(6):9885-9898
Induction of dormancy in hypoxic human papillomavirus-positive cancer cells.
Hoppe-Seyler K, Bossler F, Lohrey C, Bulkescher J, Rösl F, Jansen L, Mayer A, Vaupel P, Dürst M, Hoppe-Seyler F
Proceedings of the National Academy of Sciences of the United States of America 2017 Feb 7;114(6):E990-E998
Proceedings of the National Academy of Sciences of the United States of America 2017 Feb 7;114(6):E990-E998
EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α.
Kuan II, Liang KH, Wang YP, Kuo TW, Meir YJ, Wu SC, Yang SC, Lu J, Wu HC
Scientific reports 2017 Feb 3;7:41852
Scientific reports 2017 Feb 3;7:41852
Rho-associated kinase 1 inhibition is synthetically lethal with von Hippel-Lindau deficiency in clear cell renal cell carcinoma.
Thompson JM, Nguyen QH, Singh M, Pavesic MW, Nesterenko I, Nelson LJ, Liao AC, Razorenova OV
Oncogene 2017 Feb 23;36(8):1080-1089
Oncogene 2017 Feb 23;36(8):1080-1089
Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment.
Lu H, Chen I, Shimoda LA, Park Y, Zhang C, Tran L, Zhang H, Semenza GL
Cell reports 2017 Feb 21;18(8):1946-1957
Cell reports 2017 Feb 21;18(8):1946-1957
Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia.
Ariazi JL, Duffy KJ, Adams DF, Fitch DM, Luo L, Pappalardi M, Biju M, DiFilippo EH, Shaw T, Wiggall K, Erickson-Miller C
The Journal of pharmacology and experimental therapeutics 2017 Dec;363(3):336-347
The Journal of pharmacology and experimental therapeutics 2017 Dec;363(3):336-347
Hypoxia-activated prodrug enhances therapeutic effect of sunitinib in melanoma.
Liu S, Tetzlaff MT, Wang T, Chen X, Yang R, Kumar SM, Vultur A, Li P, Martin JS, Herlyn M, Amaravadi R, Li B, Xu X
Oncotarget 2017 Dec 29;8(70):115140-115152
Oncotarget 2017 Dec 29;8(70):115140-115152
Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression.
Sun W, Kato H, Kitajima S, Lee KL, Gradin K, Okamoto T, Poellinger L
Scientific reports 2017 Aug 3;7(1):7190
Scientific reports 2017 Aug 3;7(1):7190
Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts.
Shved N, Warsow G, Eichinger F, Hoogewijs D, Brandt S, Wild P, Kretzler M, Cohen CD, Lindenmeyer MT
Scientific reports 2017 Aug 17;7(1):8576
Scientific reports 2017 Aug 17;7(1):8576
Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer.
McGinn O, Gupta VK, Dauer P, Arora N, Sharma N, Nomura A, Dudeja V, Saluja A, Banerjee S
Scientific reports 2017 Aug 11;7(1):7872
Scientific reports 2017 Aug 11;7(1):7872
PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression.
Maugeri G, D'Amico AG, Reitano R, Magro G, Cavallaro S, Salomone S, D'Agata V
Frontiers in pharmacology 2016;7:139
Frontiers in pharmacology 2016;7:139
Hydroxyl-HIF2-alpha is potential therapeutic target for renal cell carcinomas.
Isono T, Chano T, Yoshida T, Kageyama S, Kawauchi A, Suzaki M, Yuasa T
American journal of cancer research 2016;6(10):2263-2276
American journal of cancer research 2016;6(10):2263-2276
HIF-2α Expression Regulates Sprout Formation into 3D Fibrin Matrices in Prolonged Hypoxia in Human Microvascular Endothelial Cells.
Nauta TD, Duyndam MC, Weijers EM, van Hinsbergh VM, Koolwijk P
PloS one 2016;11(8):e0160700
PloS one 2016;11(8):e0160700
Cellular Profiles and Molecular Mediators of Lesion Cascades in the Placode in Human Open Spinal Neural Tube Defects.
Kowitzke B, Cohrs G, Leuschner I, Koch A, Synowitz M, Mehdorn HM, Held-Feindt J, Knerlich-Lukoschus F
Journal of neuropathology and experimental neurology 2016 Sep;75(9):827-42
Journal of neuropathology and experimental neurology 2016 Sep;75(9):827-42
Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function.
German P, Bai S, Liu XD, Sun M, Zhou L, Kalra S, Zhang X, Minelli R, Scott KL, Mills GB, Jonasch E, Ding Z
Oncogene 2016 Sep 22;35(38):4973-80
Oncogene 2016 Sep 22;35(38):4973-80
Loss of prolyl hydroxylase domain protein 2 in vascular endothelium increases pericyte coverage and promotes pulmonary arterial remodeling.
Wang S, Zeng H, Xie XJ, Tao YK, He X, Roman RJ, Aschner JL, Chen JX
Oncotarget 2016 Sep 13;7(37):58848-58861
Oncotarget 2016 Sep 13;7(37):58848-58861
Knockdown of copper-transporting ATPase 1 (Atp7a) impairs iron flux in fully-differentiated rat (IEC-6) and human (Caco-2) intestinal epithelial cells.
Ha JH, Doguer C, Collins JF
Metallomics : integrated biometal science 2016 Sep 1;8(9):963-972
Metallomics : integrated biometal science 2016 Sep 1;8(9):963-972
Lack of P4H-TM in mice results in age-related retinal and renal alterations.
Leinonen H, Rossi M, Salo AM, Tiainen P, Hyvärinen J, Pitkänen M, Sormunen R, Miinalainen I, Zhang C, Soininen R, Kivirikko KI, Koskelainen A, Tanila H, Myllyharju J, Koivunen P
Human molecular genetics 2016 Sep 1;25(17):3810-3823
Human molecular genetics 2016 Sep 1;25(17):3810-3823
Renal Cell Carcinoma Programmed Death-ligand 1, a New Direct Target of Hypoxia-inducible Factor-2 Alpha, is Regulated by von Hippel-Lindau Gene Mutation Status.
Messai Y, Gad S, Noman MZ, Le Teuff G, Couve S, Janji B, Kammerer SF, Rioux-Leclerc N, Hasmim M, Ferlicot S, Baud V, Mejean A, Mole DR, Richard S, Eggermont AM, Albiges L, Mami-Chouaib F, Escudier B, Chouaib S
European urology 2016 Oct;70(4):623-632
European urology 2016 Oct;70(4):623-632
MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer.
Cui J, Duan B, Zhao X, Chen Y, Sun S, Deng W, Zhang Y, Du J, Chen Y, Gu L
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct;37(10):13455-13467
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct;37(10):13455-13467
FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model.
Gstalder C, Ader I, Cuvillier O
Molecular cancer therapeutics 2016 Oct;15(10):2465-2474
Molecular cancer therapeutics 2016 Oct;15(10):2465-2474
Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells.
Zhang C, Zhi WI, Lu H, Samanta D, Chen I, Gabrielson E, Semenza GL
Oncotarget 2016 Oct 4;7(40):64527-64542
Oncotarget 2016 Oct 4;7(40):64527-64542
Activation of islet 5-HT4 receptor regulates glycemic control through promoting insulin secretion.
Chen H, Hong F, Chen Y, Li J, Yao YS, Zhang Y, Zheng LF, Zhu JX
European journal of pharmacology 2016 Oct 15;789:354-361
European journal of pharmacology 2016 Oct 15;789:354-361
Chondromodulin-1 ameliorates osteoarthritis progression by inhibiting HIF-2α activity.
Zhang X, Prasadam I, Fang W, Crawford R, Xiao Y
Osteoarthritis and cartilage 2016 Nov;24(11):1970-1980
Osteoarthritis and cartilage 2016 Nov;24(11):1970-1980
Analysis of angiogenesis related factors in glioblastoma, peritumoral tissue and their derived cancer stem cells.
D'Alessio A, Proietti G, Lama G, Biamonte F, Lauriola L, Moscato U, Vescovi A, Mangiola A, Angelucci C, Sica G
Oncotarget 2016 Nov 29;7(48):78541-78556
Oncotarget 2016 Nov 29;7(48):78541-78556
Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy.
Nakayama T, Otsuka S, Kobayashi T, Okajima H, Matsumoto K, Hagiya Y, Inoue K, Shuin T, Nakajima M, Tanaka T, Ogura SI
Scientific reports 2016 Nov 18;6:36478
Scientific reports 2016 Nov 18;6:36478
HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia.
Pangou E, Befani C, Mylonis I, Samiotaki M, Panayotou G, Simos G, Liakos P
Journal of cell science 2016 Nov 15;129(22):4213-4226
Journal of cell science 2016 Nov 15;129(22):4213-4226
HIF-2α in Resting Macrophages Tempers Mitochondrial Reactive Oxygen Species To Selectively Repress MARCO-Dependent Phagocytosis.
Dehn S, DeBerge M, Yeap XY, Yvan-Charvet L, Fang D, Eltzschig HK, Miller SD, Thorp EB
Journal of immunology (Baltimore, Md. : 1950) 2016 Nov 1;197(9):3639-3649
Journal of immunology (Baltimore, Md. : 1950) 2016 Nov 1;197(9):3639-3649
Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia.
Selfridge AC, Cavadas MA, Scholz CC, Campbell EL, Welch LC, Lecuona E, Colgan SP, Barrett KE, Sporn PH, Sznajder JI, Cummins EP, Taylor CT
The Journal of biological chemistry 2016 May 27;291(22):11800-8
The Journal of biological chemistry 2016 May 27;291(22):11800-8
Human Cells Cultured under Physiological Oxygen Utilize Two Cap-binding Proteins to recruit Distinct mRNAs for Translation.
Timpano S, Uniacke J
The Journal of biological chemistry 2016 May 13;291(20):10772-82
The Journal of biological chemistry 2016 May 13;291(20):10772-82
Erratum to: Rectocutaneous fistula with transmigration of the suture: a rare delayed complication of vault fixation with the sacrospinous ligament.
Kadam PD, Chuan HH
International urogynecology journal 2016 Mar;27(3):505
International urogynecology journal 2016 Mar;27(3):505
A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity.
Mysore VS, Szablowski J, Dervan PB, Frost PJ
Molecular cancer research : MCR 2016 Mar;14(3):253-66
Molecular cancer research : MCR 2016 Mar;14(3):253-66
Metformin sensitizes sorafenib to inhibit postoperative recurrence and metastasis of hepatocellular carcinoma in orthotopic mouse models.
You A, Cao M, Guo Z, Zuo B, Gao J, Zhou H, Li H, Cui Y, Fang F, Zhang W, Song T, Li Q, Zhu X, Yin H, Sun H, Zhang T
Journal of hematology & oncology 2016 Mar 8;9:20
Journal of hematology & oncology 2016 Mar 8;9:20
Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer.
Regan Anderson TM, Ma SH, Raj GV, Cidlowski JA, Helle TM, Knutson TP, Krutilina RI, Seagroves TN, Lange CA
Cancer research 2016 Mar 15;76(6):1653-63
Cancer research 2016 Mar 15;76(6):1653-63
Synergistic Inhibitory Effects of Hypoxia and Iron Deficiency on Hepatic Glucose Response in Mouse Liver.
Nam H, Jones D, Cooksey RC, Gao Y, Sink S, Cox J, McClain DA
Diabetes 2016 Jun;65(6):1521-33
Diabetes 2016 Jun;65(6):1521-33
A HIF-1α-driven feed-forward loop augments HIF signalling in Hep3B cells by upregulation of ARNT.
Mandl M, Lieberum MK, Depping R
Cell death & disease 2016 Jun 30;7(6):e2284
Cell death & disease 2016 Jun 30;7(6):e2284
Notch-independent RBPJ controls angiogenesis in the adult heart.
Díaz-Trelles R, Scimia MC, Bushway P, Tran D, Monosov A, Monosov E, Peterson K, Rentschler S, Cabrales P, Ruiz-Lozano P, Mercola M
Nature communications 2016 Jun 30;7:12088
Nature communications 2016 Jun 30;7:12088
Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner.
Fitzpatrick SF, Fábián Z, Schaible B, Lenihan CR, Schwarzl T, Rodriguez J, Zheng X, Li Z, Tambuwala MM, Higgins DG, O'Meara Y, Slattery C, Manresa MC, Fraisl P, Bruning U, Baes M, Carmeliet P, Doherty G, von Kriegsheim A, Cummins EP, Taylor CT
Biochemical and biophysical research communications 2016 Jun 3;474(3):579-586
Biochemical and biophysical research communications 2016 Jun 3;474(3):579-586
HIFI-α activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer.
Mahara S, Lee PL, Feng M, Tergaonkar V, Chng WJ, Yu Q
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 28;113(26):E3735-44
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 28;113(26):E3735-44
Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2α.
Dai Z, Li M, Wharton J, Zhu MM, Zhao YY
Circulation 2016 Jun 14;133(24):2447-58
Circulation 2016 Jun 14;133(24):2447-58
Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity.
Hoefflin R, Lahrmann B, Warsow G, Hübschmann D, Spath C, Walter B, Chen X, Hofer L, Macher-Goeppinger S, Tolstov Y, Korzeniewski N, Duensing A, Grüllich C, Jäger D, Perner S, Schönberg G, Nyarangi-Dix J, Isaac S, Hatiboglu G, Teber D, Hadaschik B, Pahernik S, Roth W, Eils R, Schlesner M, Sültmann H, Hohenfellner M, Grabe N, Duensing S
Nature communications 2016 Jun 13;7:ncomms11845
Nature communications 2016 Jun 13;7:ncomms11845
PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species.
Warfel NA, Sainz AG, Song JH, Kraft AS
Molecular cancer therapeutics 2016 Jul;15(7):1637-47
Molecular cancer therapeutics 2016 Jul;15(7):1637-47
Thrombopoietin induces hematopoiesis from mouse ES cells via HIF-1α-dependent activation of a BMP4 autoregulatory loop.
Pramono A, Zahabi A, Morishima T, Lan D, Welte K, Skokowa J
Annals of the New York Academy of Sciences 2016 Jul;1375(1):38-51
Annals of the New York Academy of Sciences 2016 Jul;1375(1):38-51
Genome-wide analysis of HIF-2α chromatin binding sites under normoxia in human bronchial epithelial cells (BEAS-2B) suggests its diverse functions.
Lee MC, Huang HJ, Chang TH, Huang HC, Hsieh SY, Chen YS, Chou WY, Chiang CH, Lai CH, Shiau CY
Scientific reports 2016 Jul 4;6:29311
Scientific reports 2016 Jul 4;6:29311
EphrinB2 repression through ZEB2 mediates tumour invasion and anti-angiogenic resistance.
Depner C, Zum Buttel H, Böğürcü N, Cuesta AM, Aburto MR, Seidel S, Finkelmeier F, Foss F, Hofmann J, Kaulich K, Barbus S, Segarra M, Reifenberger G, Garvalov BK, Acker T, Acker-Palmer A
Nature communications 2016 Jul 29;7:12329
Nature communications 2016 Jul 29;7:12329
Hypoxia upregulates HIG2 expression and contributes to bevacizumab resistance in glioblastoma.
Mao XG, Wang C, Liu DY, Zhang X, Wang L, Yan M, Zhang W, Zhu J, Li ZC, Mi C, Tian JY, Hou GD, Miao SY, Song ZX, Li JC, Xue XY
Oncotarget 2016 Jul 26;7(30):47808-47820
Oncotarget 2016 Jul 26;7(30):47808-47820
jSplice: a high-performance method for accurate prediction of alternative splicing events and its application to large-scale renal cancer transcriptome data.
Christinat Y, Pawłowski R, Krek W
Bioinformatics (Oxford, England) 2016 Jul 15;32(14):2111-9
Bioinformatics (Oxford, England) 2016 Jul 15;32(14):2111-9
Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution.
Luo B, Wang J, Liu Z, Shen Z, Shi R, Liu YQ, Liu Y, Jiang M, Wu Y, Zhang Z
Nature communications 2016 Jul 11;7:12177
Nature communications 2016 Jul 11;7:12177
Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF-2α expression in lung cancer cells under normoxia and hypoxia.
Aquino-Gálvez A, González-Ávila G, Delgado-Tello J, Castillejos-López M, Mendoza-Milla C, Zúñiga J, Checa M, Maldonado-Martínez HA, Trinidad-López A, Cisneros J, Torres-Espíndola LM, Hernández-Jiménez C, Sommer B, Cabello-Gutiérrez C, Gutiérrez-González LH
Oncology reports 2016 Jan;35(1):577-83
Oncology reports 2016 Jan;35(1):577-83
Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation.
Cheng S, Xing W, Pourteymoor S, Schulte J, Mohan S
Endocrinology 2016 Jan;157(1):127-40
Endocrinology 2016 Jan;157(1):127-40
The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells.
Binó L, Kučera J, Štefková K, Švihálková Šindlerová L, Lánová M, Kudová J, Kubala L, Pacherník J
Chemico-biological interactions 2016 Jan 25;244:204-14
Chemico-biological interactions 2016 Jan 25;244:204-14
Methylation-dependent regulation of HIF-1α stability restricts retinal and tumour angiogenesis.
Kim Y, Nam HJ, Lee J, Park DY, Kim C, Yu YS, Kim D, Park SW, Bhin J, Hwang D, Lee H, Koh GY, Baek SH
Nature communications 2016 Jan 13;7:10347
Nature communications 2016 Jan 13;7:10347
Histone modification profiling reveals differential signatures associated with human embryonic stem cell self-renewal and differentiation.
Bhanu NV, Sidoli S, Garcia BA
Proteomics 2016 Feb;16(3):448-58
Proteomics 2016 Feb;16(3):448-58
PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia.
Luo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza GL
Oncotarget 2016 Feb 9;7(6):6379-97
Oncotarget 2016 Feb 9;7(6):6379-97
Epigenetic re-expression of HIF-2α suppresses soft tissue sarcoma growth.
Nakazawa MS, Eisinger-Mathason TS, Sadri N, Ochocki JD, Gade TP, Amin RK, Simon MC
Nature communications 2016 Feb 3;7:10539
Nature communications 2016 Feb 3;7:10539
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.
Laukka T, Mariani CJ, Ihantola T, Cao JZ, Hokkanen J, Kaelin WG Jr, Godley LA, Koivunen P
The Journal of biological chemistry 2016 Feb 19;291(8):4256-65
The Journal of biological chemistry 2016 Feb 19;291(8):4256-65
Regulation of glucose metabolism by p62/SQSTM1 through HIF1α.
Chen K, Zeng J, Xiao H, Huang C, Hu J, Yao W, Yu G, Xiao W, Xu H, Ye Z
Journal of cell science 2016 Feb 15;129(4):817-30
Journal of cell science 2016 Feb 15;129(4):817-30
LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways.
Zeng H, He X, Tuo QH, Liao DF, Zhang GQ, Chen JX
Scientific reports 2016 Feb 12;6:20931
Scientific reports 2016 Feb 12;6:20931
Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion.
Mori H, Yao Y, Learman BS, Kurozumi K, Ishida J, Ramakrishnan SK, Overmyer KA, Xue X, Cawthorn WP, Reid MA, Taylor M, Ning X, Shah YM, MacDougald OA
Scientific reports 2016 Feb 10;6:21520
Scientific reports 2016 Feb 10;6:21520
Differential hypoxic response of human choroidal and retinal endothelial cells proposes tissue heterogeneity of ocular angiogenesis.
Mammadzada P, Gudmundsson J, Kvanta A, André H
Acta ophthalmologica 2016 Dec;94(8):805-814
Acta ophthalmologica 2016 Dec;94(8):805-814
Hypoxia-Dependent HIF-1 Activation Impacts on Tissue Remodeling in Graves' Ophthalmopathy-Implications for Smoking.
Görtz GE, Horstmann M, Aniol B, Reyes BD, Fandrey J, Eckstein A, Berchner-Pfannschmidt U
The Journal of clinical endocrinology and metabolism 2016 Dec;101(12):4834-4842
The Journal of clinical endocrinology and metabolism 2016 Dec;101(12):4834-4842
Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration.
Zhang L, Du J, Justus S, Hsu CW, Bonet-Ponce L, Wu WH, Tsai YT, Wu WP, Jia Y, Duong JK, Mahajan VB, Lin CS, Wang S, Hurley JB, Tsang SH
The Journal of clinical investigation 2016 Dec 1;126(12):4659-4673
The Journal of clinical investigation 2016 Dec 1;126(12):4659-4673
pVHL-mediated degradation of HIF-2α regulates estrogen receptor α expression in normoxic breast cancer cells.
Higashimura Y, Kitakaze T, Harada N, Inui H, Nakano Y, Yamaji R
FEBS letters 2016 Aug;590(16):2690-9
FEBS letters 2016 Aug;590(16):2690-9
Bidirectional signalling between EphA2 and ephrinA1 increases tubular cell attachment, laminin secretion and modulates erythropoietin expression after renal hypoxic injury.
Rodriguez S, Rudloff S, Koenig KF, Karthik S, Hoogewijs D, Huynh-Do U
Pflugers Archiv : European journal of physiology 2016 Aug;468(8):1433-48
Pflugers Archiv : European journal of physiology 2016 Aug;468(8):1433-48
Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model.
Hoang NT, Kadonosono T, Kuchimaru T, Kizaka-Kondoh S
Cancer science 2016 Aug;107(8):1151-8
Cancer science 2016 Aug;107(8):1151-8
CD14/TLR4 priming potentially recalibrates and exerts anti-tumor efficacy in tumor associated macrophages in a mouse model of pancreatic carcinoma.
Prakash H, Nadella V, Singh S, Schmitz-Winnenthal H
Scientific reports 2016 Aug 11;6:31490
Scientific reports 2016 Aug 11;6:31490
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA.
Zhang C, Samanta D, Lu H, Bullen JW, Zhang H, Chen I, He X, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2016 Apr 5;113(14):E2047-56
Proceedings of the National Academy of Sciences of the United States of America 2016 Apr 5;113(14):E2047-56
Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling.
Heir P, Srikumar T, Bikopoulos G, Bunda S, Poon BP, Lee JE, Raught B, Ohh M
The Journal of biological chemistry 2016 Apr 1;291(14):7357-72
The Journal of biological chemistry 2016 Apr 1;291(14):7357-72
Cross regulation between hypoxia-inducible transcription factor-1α (HIF-1α) and transforming growth factor (TGF)-ß1 mediates nickel oxide nanoparticles (NiONPs)-induced pulmonary fibrosis.
Qian F, He M, Duan W, Mao L, Li Q, Yu Z, Zhou Z, Zhang Y
American journal of translational research 2015;7(11):2364-78
American journal of translational research 2015;7(11):2364-78
Prolyl-4-Hydroxylase 2 Potentially Contributes to Hepatocellular Carcinoma-Associated Erythrocytosis by Maintaining Hepatocyte Nuclear Factor-4α Expression.
Sun W, Kosyna FK, Jelkmann W, Depping R
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015;37(6):2257-64
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015;37(6):2257-64
Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes.
Wu S, Zhang J, Huang C, Jia H, Wang Y, Xu Z, Yang L, Miyagishi M, Kasim V
Current gene therapy 2015;15(3):313-25
Current gene therapy 2015;15(3):313-25
Prolyl hydroxylase domain-2 silencing induced by hydrodynamic limb vein injection enhances vascular regeneration in critical limb ischemia mice through activation of multiple genes.
Wu S, Zhang J, Huang C, Jia H, Wang Y, Xu Z, Yang L, Miyagishi M, Kasim V
Current gene therapy 2015;15(3):313-25
Current gene therapy 2015;15(3):313-25
Differential effects of HIF-α isoforms on apoptosis in renal carcinoma cell lines.
Doonachar A, Gallo MD, Doukas D, Pasricha R, Lantsberg I, Schoenfeld AR
Cancer cell international 2015;15:23
Cancer cell international 2015;15:23
Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.
Saini Y, Proper SP, Dornbos P, Greenwood KK, Kopec AK, Lynn SG, Grier E, Burgoon LD, Zacharewski TR, Thomas RS, Harkema JR, LaPres JJ
PloS one 2015;10(9):e0139270
PloS one 2015;10(9):e0139270
Pharmacological inhibition of FTO.
McMurray F, Demetriades M, Aik W, Merkestein M, Kramer H, Andrew DS, Scudamore CL, Hough TA, Wells S, Ashcroft FM, McDonough MA, Schofield CJ, Cox RD
PloS one 2015;10(4):e0121829
PloS one 2015;10(4):e0121829
The acetate/ACSS2 switch regulates HIF-2 stress signaling in the tumor cell microenvironment.
Chen R, Xu M, Nagati JS, Hogg RT, Das A, Gerard RD, Garcia JA
PloS one 2015;10(2):e0116515
PloS one 2015;10(2):e0116515
HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression.
Shao J, Zhang Y, Yang T, Qi J, Zhang L, Deng L
In vitro cellular & developmental biology. Animal 2015 Sep;51(8):808-14
In vitro cellular & developmental biology. Animal 2015 Sep;51(8):808-14
Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis.
Singleton DC, Rouhi P, Zois CE, Haider S, Li JL, Kessler BM, Cao Y, Harris AL
Oncogene 2015 Sep 3;34(36):4713-22
Oncogene 2015 Sep 3;34(36):4713-22
The In Vitro and In Vivo Activity of the Microtubule Disruptor STX140 Is Mediated by Hif-1 Alpha and CAIX Expression.
Stengel C, Newman SP, Leese MP, Thomas MP, Potter BV, Reed MJ, Purohit A, Foster PA
Anticancer research 2015 Oct;35(10):5249-61
Anticancer research 2015 Oct;35(10):5249-61
Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML.
Forristal CE, Brown AL, Helwani FM, Winkler IG, Nowlan B, Barbier V, Powell RJ, Engler GA, Diakiw SM, Zannettino AC, Martin S, Pattabiraman D, D'Andrea RJ, Lewis ID, Levesque JP
Leukemia 2015 Oct;29(10):2075-85
Leukemia 2015 Oct;29(10):2075-85
HIF-2α-induced chemokines stimulate motility of fibroblast-like synoviocytes and chondrocytes into the cartilage-pannus interface in experimental rheumatoid arthritis mouse models.
Huh YH, Lee G, Lee KB, Koh JT, Chun JS, Ryu JH
Arthritis research & therapy 2015 Oct 29;17:302
Arthritis research & therapy 2015 Oct 29;17:302
The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines cellular survival after radiation treatment.
Mandl M, Lieberum M, Dunst J, Depping R
Radiation oncology (London, England) 2015 Nov 16;10:229
Radiation oncology (London, England) 2015 Nov 16;10:229
PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation.
Qi Y, Liu J, Saadat S, Tian X, Han Y, Fong GH, Pandolfi PP, Lee LY, Li S
Cell death and differentiation 2015 May;22(5):875-84
Cell death and differentiation 2015 May;22(5):875-84
Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat.
Cotroneo E, Ashek A, Wang L, Wharton J, Dubois O, Bozorgi S, Busbridge M, Alavian KN, Wilkins MR, Zhao L
Circulation research 2015 May 8;116(10):1680-90
Circulation research 2015 May 8;116(10):1680-90
Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis.
Liu XD, Yao J, Tripathi DN, Ding Z, Xu Y, Sun M, Zhang J, Bai S, German P, Hoang A, Zhou L, Jonasch D, Zhang X, Conti CJ, Efstathiou E, Tannir NM, Eissa NT, Mills GB, Walker CL, Jonasch E
Oncogene 2015 May 7;34(19):2450-60
Oncogene 2015 May 7;34(19):2450-60
FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation.
El Assar M, Sánchez-Puelles JM, Royo I, López-Hernández E, Sánchez-Ferrer A, Aceña JL, Rodríguez-Mañas L, Angulo J
British journal of pharmacology 2015 Mar;172(5):1277-91
British journal of pharmacology 2015 Mar;172(5):1277-91
Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition.
Bonora M, Wieckowsk MR, Chinopoulos C, Kepp O, Kroemer G, Galluzzi L, Pinton P
Oncogene 2015 Mar 19;34(12):1608
Oncogene 2015 Mar 19;34(12):1608
HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma.
Qiu B, Ackerman D, Sanchez DJ, Li B, Ochocki JD, Grazioli A, Bobrovnikova-Marjon E, Diehl JA, Keith B, Simon MC
Cancer discovery 2015 Jun;5(6):652-67
Cancer discovery 2015 Jun;5(6):652-67
Increased expression of HIF2α during iron deficiency-associated megakaryocytic differentiation.
Jimenez K, Khare V, Evstatiev R, Kulnigg-Dabsch S, Jambrich M, Strobl H, Gasche C
Journal of thrombosis and haemostasis : JTH 2015 Jun;13(6):1113-27
Journal of thrombosis and haemostasis : JTH 2015 Jun;13(6):1113-27
Impaired expression of HIF-2α induces compensatory expression of HIF-1α for the recovery from anemia.
Tsuboi I, Yamashita T, Nagano M, Kimura K, To'a Salazar G, Ohneda O
Journal of cellular physiology 2015 Jul;230(7):1534-48
Journal of cellular physiology 2015 Jul;230(7):1534-48
STAT3 and HIF1α Signaling Drives Oncogenic Cellular Phenotypes in Malignant Peripheral Nerve Sheath Tumors.
Rad E, Dodd K, Thomas L, Upadhyaya M, Tee A
Molecular cancer research : MCR 2015 Jul;13(7):1149-60
Molecular cancer research : MCR 2015 Jul;13(7):1149-60
Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27.
Högel H, Miikkulainen P, Bino L, Jaakkola PM
Molecular cancer 2015 Jul 30;14:143
Molecular cancer 2015 Jul 30;14:143
Maternal intestinal HIF-2α is necessary for sensing iron demands of lactation in mice.
Ramakrishnan SK, Anderson ER, Martin A, Centofanti B, Shah YM
Proceedings of the National Academy of Sciences of the United States of America 2015 Jul 14;112(28):E3738-47
Proceedings of the National Academy of Sciences of the United States of America 2015 Jul 14;112(28):E3738-47
Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD.
Yoo S, Takikawa S, Geraghty P, Argmann C, Campbell J, Lin L, Huang T, Tu Z, Foronjy RF, Spira A, Schadt EE, Powell CA, Zhu J
PLoS genetics 2015 Jan;11(1):e1004898
PLoS genetics 2015 Jan;11(1):e1004898
Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT).
Su EJ, Xin H, Yin P, Dyson M, Coon J, Farrow KN, Mestan KK, Ernst LM
The Journal of clinical endocrinology and metabolism 2015 Jan;100(1):E30-40
The Journal of clinical endocrinology and metabolism 2015 Jan;100(1):E30-40
Hypoxia-induced SUMOylation of E3 ligase HAF determines specific activation of HIF2 in clear-cell renal cell carcinoma.
Koh MY, Nguyen V, Lemos R Jr, Darnay BG, Kiriakova G, Abdelmelek M, Ho TH, Karam J, Monzon FA, Jonasch E, Powis G
Cancer research 2015 Jan 15;75(2):316-29
Cancer research 2015 Jan 15;75(2):316-29
Hypoxia-inducible factors regulate filaggrin expression and epidermal barrier function.
Wong WJ, Richardson T, Seykora JT, Cotsarelis G, Simon MC
The Journal of investigative dermatology 2015 Feb;135(2):454-461
The Journal of investigative dermatology 2015 Feb;135(2):454-461
Hypoxia promotes dissemination and colonization in new bone marrow niches in Waldenström macroglobulinemia.
Muz B, de la Puente P, Azab F, Ghobrial IM, Azab AK
Molecular cancer research : MCR 2015 Feb;13(2):263-72
Molecular cancer research : MCR 2015 Feb;13(2):263-72
HIF2α signaling inhibits adherens junctional disruption in acute lung injury.
Gong H, Rehman J, Tang H, Wary K, Mittal M, Chaturvedi P, Zhao YY, Komarova YA, Vogel SM, Malik AB
The Journal of clinical investigation 2015 Feb;125(2):652-64
The Journal of clinical investigation 2015 Feb;125(2):652-64
The inhibitory effect of hypoxic cytotoxin on the expansion of cancer stem cells in ovarian cancer.
Nozawa-Suzuki N, Nagasawa H, Ohnishi K, Morishige K
Biochemical and biophysical research communications 2015 Feb 20;457(4):706-11
Biochemical and biophysical research communications 2015 Feb 20;457(4):706-11
Hypoxia up-regulates SERPINB3 through HIF-2α in human liver cancer cells.
Cannito S, Turato C, Paternostro C, Biasiolo A, Colombatto S, Cambieri I, Quarta S, Novo E, Morello E, Villano G, Fasolato S, Musso T, David E, Tusa I, Rovida E, Autelli R, Smedile A, Cillo U, Pontisso P, Parola M
Oncotarget 2015 Feb 10;6(4):2206-21
Oncotarget 2015 Feb 10;6(4):2206-21
Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion.
Highet AR, Khoda SM, Buckberry S, Leemaqz S, Bianco-Miotto T, Harrington E, Ricciardelli C, Roberts CT
European journal of cell biology 2015 Dec;94(12):589-602
European journal of cell biology 2015 Dec;94(12):589-602
Oxygen Sensitivity of Placental Trophoblast Connexins 43 and 46: A Role in Preeclampsia?
Otto T, Gellhaus A, Lüschen N, Scheidler J, Bendix I, Dunk C, Wolf N, Lennartz K, Köninger A, Schmidt M, Kimmig R, Fandrey J, Winterhager E
Journal of cellular biochemistry 2015 Dec;116(12):2924-37
Journal of cellular biochemistry 2015 Dec;116(12):2924-37
REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia.
Cavadas MA, Mesnieres M, Crifo B, Manresa MC, Selfridge AC, Scholz CC, Cummins EP, Cheong A, Taylor CT
Scientific reports 2015 Dec 9;5:17851
Scientific reports 2015 Dec 9;5:17851
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
Zhang J, Wang C, Chen X, Takada M, Fan C, Zheng X, Wen H, Liu Y, Wang C, Pestell RG, Aird KM, Kaelin WG Jr, Liu XS, Zhang Q
The EMBO journal 2015 Dec 2;34(23):2953-70
The EMBO journal 2015 Dec 2;34(23):2953-70
Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance.
Vukovic M, Guitart AV, Sepulveda C, Villacreces A, O'Duibhir E, Panagopoulou TI, Ivens A, Menendez-Gonzalez J, Iglesias JM, Allen L, Glykofrydis F, Subramani C, Armesilla-Diaz A, Post AE, Schaak K, Gezer D, So CW, Holyoake TL, Wood A, O'Carroll D, Ratcliffe PJ, Kranc KR
The Journal of experimental medicine 2015 Dec 14;212(13):2223-34
The Journal of experimental medicine 2015 Dec 14;212(13):2223-34
High-fat diet induces cardiac remodelling and dysfunction: assessment of the role played by SIRT3 loss.
Zeng H, Vaka VR, He X, Booz GW, Chen JX
Journal of cellular and molecular medicine 2015 Aug;19(8):1847-56
Journal of cellular and molecular medicine 2015 Aug;19(8):1847-56
Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype.
Lu H, Samanta D, Xiang L, Zhang H, Hu H, Chen I, Bullen JW, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2015 Aug 18;112(33):E4600-9
Proceedings of the National Academy of Sciences of the United States of America 2015 Aug 18;112(33):E4600-9
Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system.
Matsuyama T, Tanaka T, Tatsumi K, Daijo H, Kai S, Harada H, Fukuda K
European journal of pharmacology 2015 Aug 15;761:189-98
European journal of pharmacology 2015 Aug 15;761:189-98
Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection.
Lin AE, Beasley FC, Olson J, Keller N, Shalwitz RA, Hannan TJ, Hultgren SJ, Nizet V
PLoS pathogens 2015 Apr;11(4):e1004818
PLoS pathogens 2015 Apr;11(4):e1004818
Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer.
Koizume S, Ito S, Nakamura Y, Yoshihara M, Furuya M, Yamada R, Miyagi E, Hirahara F, Takano Y, Miyagi Y
Molecular cancer 2015 Apr 8;14:77
Molecular cancer 2015 Apr 8;14:77
Myeloid HIF-1 is protective in Helicobacter pylori-mediated gastritis.
Matak P, Heinis M, Mathieu JR, Corriden R, Cuvellier S, Delga S, Mounier R, Rouquette A, Raymond J, Lamarque D, Emile JF, Nizet V, Touati E, Peyssonnaux C
Journal of immunology (Baltimore, Md. : 1950) 2015 Apr 1;194(7):3259-66
Journal of immunology (Baltimore, Md. : 1950) 2015 Apr 1;194(7):3259-66
Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation.
Asnaghi L, Lin MH, Lim KS, Lim KJ, Tripathy A, Wendeborn M, Merbs SL, Handa JT, Sodhi A, Bar EE, Eberhart CG
PloS one 2014;9(8):e105372
PloS one 2014;9(8):e105372
HIF1α and HIF2α exert distinct nutrient preferences in renal cells.
Arreola A, Cowey CL, Coloff JL, Rathmell JC, Rathmell WK
PloS one 2014;9(5):e98705
PloS one 2014;9(5):e98705
Deletion of hypoxia-inducible factor-1α in adipocytes enhances glucagon-like peptide-1 secretion and reduces adipose tissue inflammation.
Kihira Y, Miyake M, Hirata M, Hoshina Y, Kato K, Shirakawa H, Sakaue H, Yamano N, Izawa-Ishizawa Y, Ishizawa K, Ikeda Y, Tsuchiya K, Tamaki T, Tomita S
PloS one 2014;9(4):e93856
PloS one 2014;9(4):e93856
Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2.
Hou P, Kuo CY, Cheng CT, Liou JP, Ann DK, Chen Q
PloS one 2014;9(11):e113865
PloS one 2014;9(11):e113865
HIF-2α regulates NANOG expression in human embryonic stem cells following hypoxia and reoxygenation through the interaction with an Oct-Sox cis regulatory element.
Petruzzelli R, Christensen DR, Parry KL, Sanchez-Elsner T, Houghton FD
PloS one 2014;9(10):e108309
PloS one 2014;9(10):e108309
Lenticular cytoprotection, part 2: link between glycogen synthase kinase-3β, epithelial to mesenchymal transition, and mitochondrial depolarization.
Neelam S, Brooks MM, Cammarata PR
Molecular vision 2014;20:1758-75
Molecular vision 2014;20:1758-75
Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model.
Zhang X, Zhu J, Liu F, Li Y, Chandra A, Levin LS, Beier F, Enomoto-Iwamoto M, Qin L
Bone research 2014;2:14015
Bone research 2014;2:14015
Hypoxia-inducible factor-1α restricts the anabolic actions of parathyroid hormone.
Frey JL, Stonko DP, Faugere MC, Riddle RC
Bone research 2014;2:14005
Bone research 2014;2:14005
Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2α and ETS1.
Fiorito V, Neri F, Pala V, Silengo L, Oliviero S, Altruda F, Tolosano E
Biochimica et biophysica acta 2014;1839(4):259-64
Biochimica et biophysica acta 2014;1839(4):259-64
miR455 is linked to hypoxia signaling and is deregulated in preeclampsia.
Lalevée S, Lapaire O, Bühler M
Cell death & disease 2014 Sep 4;5:e1408
Cell death & disease 2014 Sep 4;5:e1408
Fructose-1,6-bisphosphatase opposes renal carcinoma progression.
Li B, Qiu B, Lee DS, Walton ZE, Ochocki JD, Mathew LK, Mancuso A, Gade TP, Keith B, Nissim I, Simon MC
Nature 2014 Sep 11;513(7517):251-5
Nature 2014 Sep 11;513(7517):251-5
Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development.
Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Rankin EB, Giaccia AJ, Schipani E
Developmental biology 2014 Sep 1;393(1):124-36
Developmental biology 2014 Sep 1;393(1):124-36
Submersion and hypoxia inhibit ciliated cell differentiation in a notch-dependent manner.
Gerovac BJ, Valencia M, Baumlin N, Salathe M, Conner GE, Fregien NL
American journal of respiratory cell and molecular biology 2014 Oct;51(4):516-25
American journal of respiratory cell and molecular biology 2014 Oct;51(4):516-25
Ouabain inhibits placental sFlt1 production by repressing HSP27-dependent HIF-1α pathway.
Rana S, Rajakumar A, Geahchan C, Salahuddin S, Cerdeira AS, Burke SD, George EM, Granger JP, Karumanchi SA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Oct;28(10):4324-34
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Oct;28(10):4324-34
Decreased expression of cystathionine β-synthase promotes glioma tumorigenesis.
Takano N, Sarfraz Y, Gilkes DM, Chaturvedi P, Xiang L, Suematsu M, Zagzag D, Semenza GL
Molecular cancer research : MCR 2014 Oct;12(10):1398-406
Molecular cancer research : MCR 2014 Oct;12(10):1398-406
Hypoxia-inducible factors enhance glutamate signaling in cancer cells.
Hu H, Takano N, Xiang L, Gilkes DM, Luo W, Semenza GL
Oncotarget 2014 Oct 15;5(19):8853-68
Oncotarget 2014 Oct 15;5(19):8853-68
Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst.
Kono K, Tamashiro DA, Alarcon VB
Developmental biology 2014 Oct 1;394(1):142-55
Developmental biology 2014 Oct 1;394(1):142-55
Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy.
Wu R, Chang HC, Khechaduri A, Chawla K, Tran M, Chai X, Wagg C, Ghanefar M, Jiang X, Bayeva M, Gonzalez F, Lopaschuk G, Ardehali H
The Journal of clinical investigation 2014 Nov;124(11):4795-806
The Journal of clinical investigation 2014 Nov;124(11):4795-806
Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion.
Fujikuni N, Yamamoto H, Tanabe K, Naito Y, Sakamoto N, Tanaka Y, Yanagihara K, Oue N, Yasui W, Ohdan H
Cancer science 2014 Nov;105(11):1411-20
Cancer science 2014 Nov;105(11):1411-20
Loss of PHD3 allows tumours to overcome hypoxic growth inhibition and sustain proliferation through EGFR.
Henze AT, Garvalov BK, Seidel S, Cuesta AM, Ritter M, Filatova A, Foss F, Dopeso H, Essmann CL, Maxwell PH, Reifenberger G, Carmeliet P, Acker-Palmer A, Acker T
Nature communications 2014 Nov 25;5:5582
Nature communications 2014 Nov 25;5:5582
Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC-associated factor X.
Qin N, de Cubas AA, Garcia-Martin R, Richter S, Peitzsch M, Menschikowski M, Lenders JW, Timmers HJ, Mannelli M, Opocher G, Economopoulou M, Siegert G, Chavakis T, Pacak K, Robledo M, Eisenhofer G
International journal of cancer 2014 Nov 1;135(9):2054-64
International journal of cancer 2014 Nov 1;135(9):2054-64
Protein profiling of Helicobacter pylori-associated gastric cancer.
Lian G, Wei C, Wang D, Cui M, Wang Z, Liu X, Li W, Wang L, Wang Q, Zhang DY, Suo J, Ye F
The American journal of pathology 2014 May;184(5):1343-54
The American journal of pathology 2014 May;184(5):1343-54
CD34+/CD45-dim stem cell mobilization by hyperbaric oxygen - changes with oxygen dosage.
Heyboer M 3rd, Milovanova TN, Wojcik S, Grant W, Chin M, Hardy KR, Lambert DS, Logue C, Thom SR
Stem cell research 2014 May;12(3):638-45
Stem cell research 2014 May;12(3):638-45
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment.
Chaturvedi P, Gilkes DM, Takano N, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2014 May 20;111(20):E2120-9
Proceedings of the National Academy of Sciences of the United States of America 2014 May 20;111(20):E2120-9
FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter.
Zhu J, Jiang X, Chehab FF
Journal of lipid research 2014 Mar;55(3):431-42
Journal of lipid research 2014 Mar;55(3):431-42
Calpains promote neutrophil recruitment and bacterial clearance in an acute bacterial peritonitis model.
Kumar V, Everingham S, Hall C, Greer PA, Craig AW
European journal of immunology 2014 Mar;44(3):831-41
European journal of immunology 2014 Mar;44(3):831-41
EAF2 suppresses hypoxia-induced factor 1α transcriptional activity by disrupting its interaction with coactivator CBP/p300.
Chen Z, Liu X, Mei Z, Wang Z, Xiao W
Molecular and cellular biology 2014 Mar;34(6):1085-99
Molecular and cellular biology 2014 Mar;34(6):1085-99
Epidermal deletion of HIF-2α stimulates wound closure.
Cowburn AS, Alexander LEC, Southwood M, Nizet V, Chilvers ER, Johnson RS
The Journal of investigative dermatology 2014 Mar;134(3):801-808
The Journal of investigative dermatology 2014 Mar;134(3):801-808
STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells.
Pawlus MR, Wang L, Hu CJ
Oncogene 2014 Mar 27;33(13):1670-9
Oncogene 2014 Mar 27;33(13):1670-9
Hypoxia-inducible factors regulate human and rat cystathionine β-synthase gene expression.
Takano N, Peng YJ, Kumar GK, Luo W, Hu H, Shimoda LA, Suematsu M, Prabhakar NR, Semenza GL
The Biochemical journal 2014 Mar 1;458(2):203-11
The Biochemical journal 2014 Mar 1;458(2):203-11
Hypoxia inducible factor 2α/insulin-like growth factor receptor signal loop supports the proliferation and Oct-4 maintenance of mouse germline stem cells.
Huang YH, Lin MH, Wang PC, Wu YC, Chiang HL, Wang YL, Chang JH, Huang YK, Gu SY, Ho HN, Ling TY
Molecular human reproduction 2014 Jun;20(6):526-37
Molecular human reproduction 2014 Jun;20(6):526-37
Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation.
Yoshizawa S, Brown A, Barchowsky A, Sfeir C
Acta biomaterialia 2014 Jun;10(6):2834-42
Acta biomaterialia 2014 Jun;10(6):2834-42
Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein.
Ding Z, German P, Bai S, Reddy AS, Liu XD, Sun M, Zhou L, Chen X, Zhao X, Wu C, Zhang S, Mills GB, Jonasch E
Cancer research 2014 Jun 1;74(11):3127-36
Cancer research 2014 Jun 1;74(11):3127-36
Intrinsic bevacizumab resistance is associated with prolonged activation of autocrine VEGF signaling and hypoxia tolerance in colorectal cancer cells and can be overcome by nintedanib, a small molecule angiokinase inhibitor.
Mésange P, Poindessous V, Sabbah M, Escargueil AE, de Gramont A, Larsen AK
Oncotarget 2014 Jul 15;5(13):4709-21
Oncotarget 2014 Jul 15;5(13):4709-21
Modulation of Dcytb (Cybrd 1) expression and function by iron, dehydroascorbate and Hif-2α in cultured cells.
Luo X, Hill M, Johnson A, Latunde-Dada GO
Biochimica et biophysica acta 2014 Jan;1840(1):106-12
Biochimica et biophysica acta 2014 Jan;1840(1):106-12
Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway.
Zhang J, Ma WY
Genetics and molecular research : GMR 2014 Jan 24;13(4):9324-35
Genetics and molecular research : GMR 2014 Jan 24;13(4):9324-35
Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells.
Gilkes DM, Xiang L, Lee SJ, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2014 Jan 21;111(3):E384-93
Proceedings of the National Academy of Sciences of the United States of America 2014 Jan 21;111(3):E384-93
Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer.
Xiang L, Gilkes DM, Chaturvedi P, Luo W, Hu H, Takano N, Liang H, Semenza GL
Journal of molecular medicine (Berlin, Germany) 2014 Feb;92(2):151-64
Journal of molecular medicine (Berlin, Germany) 2014 Feb;92(2):151-64
[Recommendation for vaccination against polio].
Glasmacher S
Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) 2014 Feb;76(2):71
Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) 2014 Feb;76(2):71
[Recommendation for vaccination against polio].
Glasmacher S
Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) 2014 Feb;76(2):71
Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) 2014 Feb;76(2):71
Regulation of the HIF-system in human macrophages--differential regulation of HIF-α subunits under sustained hypoxia.
Poitz DM, Augstein A, Hesse K, Christoph M, Ibrahim K, Braun-Dullaeus RC, Strasser RH, Schmeißer A
Molecular immunology 2014 Feb;57(2):226-35
Molecular immunology 2014 Feb;57(2):226-35
The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells.
Razorenova OV, Castellini L, Colavitti R, Edgington LE, Nicolau M, Huang X, Bedogni B, Mills EM, Bogyo M, Giaccia AJ
Molecular and cellular biology 2014 Feb;34(4):739-51
Molecular and cellular biology 2014 Feb;34(4):739-51
Expression of Cox-2 in human breast cancer cells as a critical determinant of epithelial-to-mesenchymal transition and invasiveness.
Bocca C, Ievolella M, Autelli R, Motta M, Mosso L, Torchio B, Bozzo F, Cannito S, Paternostro C, Colombatto S, Parola M, Miglietta A
Expert opinion on therapeutic targets 2014 Feb;18(2):121-35
Expert opinion on therapeutic targets 2014 Feb;18(2):121-35
Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury.
Proper SP, Saini Y, Greenwood KK, Bramble LA, Downing NJ, Harkema JR, Lapres JJ
Toxicological sciences : an official journal of the Society of Toxicology 2014 Feb;137(2):447-57
Toxicological sciences : an official journal of the Society of Toxicology 2014 Feb;137(2):447-57
Dysregulated D-dopachrome tautomerase, a hypoxia-inducible factor-dependent gene, cooperates with macrophage migration inhibitory factor in renal tumorigenesis.
Pasupuleti V, Du W, Gupta Y, Yeh IJ, Montano M, Magi-Galuzzi C, Welford SM
The Journal of biological chemistry 2014 Feb 7;289(6):3713-23
The Journal of biological chemistry 2014 Feb 7;289(6):3713-23
CTGF is a therapeutic target for metastatic melanoma.
Finger EC, Cheng CF, Williams TR, Rankin EB, Bedogni B, Tachiki L, Spong S, Giaccia AJ, Powell MB
Oncogene 2014 Feb 27;33(9):1093-100
Oncogene 2014 Feb 27;33(9):1093-100
Interaction between PARP-1 and HIF-2α in the hypoxic response.
Gonzalez-Flores A, Aguilar-Quesada R, Siles E, Pozo S, Rodríguez-Lara MI, López-Jiménez L, López-Rodríguez M, Peralta-Leal A, Villar D, Martín-Oliva D, del Peso L, Berra E, Oliver FJ
Oncogene 2014 Feb 13;33(7):891-8
Oncogene 2014 Feb 13;33(7):891-8
Inflammatory cytokine tumor necrosis factor α suppresses neuroprotective endogenous erythropoietin from astrocytes mediated by hypoxia-inducible factor-2α.
Nagaya Y, Aoyama M, Tamura T, Kakita H, Kato S, Hida H, Saitoh S, Asai K
The European journal of neuroscience 2014 Dec;40(11):3620-6
The European journal of neuroscience 2014 Dec;40(11):3620-6
Hypoxia-inducible factor-2α (HIF-2α), but not HIF-1α, is essential for hypoxic induction of class III β-tubulin expression in human glioblastoma cells.
Bordji K, Grandval A, Cuhna-Alves L, Lechapt-Zalcman E, Bernaudin M
The FEBS journal 2014 Dec;281(23):5220-36
The FEBS journal 2014 Dec;281(23):5220-36
LIMK1 regulates human trophoblast invasion/differentiation and is down-regulated in preeclampsia.
Zhou Y, Yuge A, Rajah AM, Unek G, Rinaudo PF, Maltepe E
The American journal of pathology 2014 Dec;184(12):3321-31
The American journal of pathology 2014 Dec;184(12):3321-31
Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype.
Xiang L, Gilkes DM, Hu H, Takano N, Luo W, Lu H, Bullen JW, Samanta D, Liang H, Semenza GL
Oncotarget 2014 Dec 30;5(24):12509-27
Oncotarget 2014 Dec 30;5(24):12509-27
A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α.
Chen SJ, Hoffman NE, Shanmughapriya S, Bao L, Keefer K, Conrad K, Merali S, Takahashi Y, Abraham T, Hirschler-Laszkiewicz I, Wang J, Zhang XQ, Song J, Barrero C, Shi Y, Kawasawa YI, Bayerl M, Sun T, Barbour M, Wang HG, Madesh M, Cheung JY, Miller BA
The Journal of biological chemistry 2014 Dec 26;289(52):36284-302
The Journal of biological chemistry 2014 Dec 26;289(52):36284-302
Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells.
Samanta D, Gilkes DM, Chaturvedi P, Xiang L, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2014 Dec 16;111(50):E5429-38
Proceedings of the National Academy of Sciences of the United States of America 2014 Dec 16;111(50):E5429-38
The role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways.
Slominski A, Kim TK, Brożyna AA, Janjetovic Z, Brooks DL, Schwab LP, Skobowiat C, Jóźwicki W, Seagroves TN
Archives of biochemistry and biophysics 2014 Dec 1;563:79-93
Archives of biochemistry and biophysics 2014 Dec 1;563:79-93
Role of magnesium ions on osteogenic response in bone marrow stromal cells.
Yoshizawa S, Brown A, Barchowsky A, Sfeir C
Connective tissue research 2014 Aug;55 Suppl 1:155-9
Connective tissue research 2014 Aug;55 Suppl 1:155-9
Multivariate signaling regulation by SHP2 differentially controls proliferation and therapeutic response in glioma cells.
Furcht CM, Buonato JM, Skuli N, Mathew LK, Muñoz Rojas AR, Simon MC, Lazzara MJ
Journal of cell science 2014 Aug 15;127(Pt 16):3555-67
Journal of cell science 2014 Aug 15;127(Pt 16):3555-67
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression.
Hubbi ME, Gilkes DM, Hu H, Kshitiz, Ahmed I, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2014 Aug 12;111(32):E3325-34
Proceedings of the National Academy of Sciences of the United States of America 2014 Aug 12;111(32):E3325-34
Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2α and protein kinase A.
Salman S, Holloway AC, Nurse CA
American journal of physiology. Cell physiology 2014 Aug 1;307(3):C266-77
American journal of physiology. Cell physiology 2014 Aug 1;307(3):C266-77
Hematological, hepatic, and retinal phenotypes in mice deficient for prolyl hydroxylase domain proteins in the liver.
Duan LJ, Takeda K, Fong GH
The American journal of pathology 2014 Apr;184(4):1240-1250
The American journal of pathology 2014 Apr;184(4):1240-1250
Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling.
Weisel FC, Kloepping C, Pichl A, Sydykov A, Kojonazarov B, Wilhelm J, Roth M, Ridge KM, Igarashi K, Nishimura K, Maison W, Wackendorff C, Klepetko W, Jaksch P, Ghofrani HA, Grimminger F, Seeger W, Schermuly RT, Weissmann N, Kwapiszewska G
Circulation 2014 Apr 8;129(14):1510-23
Circulation 2014 Apr 8;129(14):1510-23
Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.
Wojciak-Stothard B, Abdul-Salam VB, Lao KH, Tsang H, Irwin DC, Lisk C, Loomis Z, Stenmark KR, Edwards JC, Yuspa SH, Howard LS, Edwards RJ, Rhodes CJ, Gibbs JS, Wharton J, Zhao L, Wilkins MR
Circulation 2014 Apr 29;129(17):1770-80
Circulation 2014 Apr 29;129(17):1770-80
STAT3 or USF2 contributes to HIF target gene specificity.
Pawlus MR, Wang L, Murakami A, Dai G, Hu CJ
PloS one 2013;8(8):e72358
PloS one 2013;8(8):e72358
Environmental oxygen tension regulates the energy metabolism and self-renewal of human embryonic stem cells.
Forristal CE, Christensen DR, Chinnery FE, Petruzzelli R, Parry KL, Sanchez-Elsner T, Houghton FD
PloS one 2013;8(5):e62507
PloS one 2013;8(5):e62507
Copper deficiency leads to anemia, duodenal hypoxia, upregulation of HIF-2α and altered expression of iron absorption genes in mice.
Matak P, Zumerle S, Mastrogiannaki M, El Balkhi S, Delga S, Mathieu JR, Canonne-Hergaux F, Poupon J, Sharp PA, Vaulont S, Peyssonnaux C
PloS one 2013;8(3):e59538
PloS one 2013;8(3):e59538
Downregulation of carbonic anhydrase IX promotes Col10a1 expression in chondrocytes.
Maruyama T, Miyamoto Y, Yamamoto G, Yamada A, Yoshimura K, Suzawa T, Takami M, Akiyama T, Hoshino M, Iwasa F, Ikumi N, Tachikawa T, Mishima K, Baba K, Kamijo R
PloS one 2013;8(2):e56984
PloS one 2013;8(2):e56984
ECM-dependent HIF induction directs trophoblast stem cell fate via LIMK1-mediated cytoskeletal rearrangement.
Choi HJ, Sanders TA, Tormos KV, Ameri K, Tsai JD, Park AM, Gonzalez J, Rajah AM, Liu X, Quinonez DM, Rinaudo PF, Maltepe E
PloS one 2013;8(2):e56949
PloS one 2013;8(2):e56949
Prolyl-4-hydroxylase 3 (PHD3) expression is downregulated during epithelial-to-mesenchymal transition.
Place TL, Nauseef JT, Peterson MK, Henry MD, Mezhir JJ, Domann FE
PloS one 2013;8(12):e83021
PloS one 2013;8(12):e83021
Prognostic value and clinicopathological differences of HIFs in colorectal cancer: evidence from meta-analysis.
Chen Z, He X, Xia W, Huang Q, Zhang Z, Ye J, Ni C, Wu P, Wu D, Xu J, Qiu F, Huang J
PloS one 2013;8(12):e80337
PloS one 2013;8(12):e80337
MicroRNA-17, 20a regulates the proangiogenic function of tumor-associated macrophages via targeting hypoxia-inducible factor 2α.
Xu Z, Zhao L, Zhu LY, He M, Zheng L, Wu Y
PloS one 2013;8(10):e77890
PloS one 2013;8(10):e77890
Xanthine oxidase mediates hypoxia-inducible factor-2α degradation by intermittent hypoxia.
Nanduri J, Vaddi DR, Khan SA, Wang N, Makerenko V, Prabhakar NR
PloS one 2013;8(10):e75838
PloS one 2013;8(10):e75838
Lenticular cytoprotection. Part 1: the role of hypoxia inducible factors-1α and -2α and vascular endothelial growth factor in lens epithelial cell survival in hypoxia.
Neelam S, Brooks MM, Cammarata PR
Molecular vision 2013;19:1-15
Molecular vision 2013;19:1-15
VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy.
Kim M, Park HJ, Seol JW, Jang JY, Cho YS, Kim KR, Choi Y, Lydon JP, Demayo FJ, Shibuya M, Ferrara N, Sung HK, Nagy A, Alitalo K, Koh GY
EMBO molecular medicine 2013 Sep;5(9):1415-30
EMBO molecular medicine 2013 Sep;5(9):1415-30
MYC degradation under low O2 tension promotes survival by evading hypoxia-induced cell death.
Wong WJ, Qiu B, Nakazawa MS, Qing G, Simon MC
Molecular and cellular biology 2013 Sep;33(17):3494-504
Molecular and cellular biology 2013 Sep;33(17):3494-504
Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels.
Parks SK, Mazure NM, Counillon L, Pouysségur J
Journal of cellular physiology 2013 Sep;228(9):1854-62
Journal of cellular physiology 2013 Sep;228(9):1854-62
HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium.
Eckle T, Brodsky K, Bonney M, Packard T, Han J, Borchers CH, Mariani TJ, Kominsky DJ, Mittelbronn M, Eltzschig HK
PLoS biology 2013 Sep;11(9):e1001665
PLoS biology 2013 Sep;11(9):e1001665
Activin A regulation under global hypoxia in developing mouse brain.
Brackmann FA, Link AS, Jung S, Richter M, Zoglauer D, Walkinshaw G, Alzheimer C, Trollmann R
Brain research 2013 Sep 19;1531:65-74
Brain research 2013 Sep 19;1531:65-74
Role of hepatic resident and infiltrating macrophages in liver repair after acute injury.
You Q, Holt M, Yin H, Li G, Hu CJ, Ju C
Biochemical pharmacology 2013 Sep 15;86(6):836-43
Biochemical pharmacology 2013 Sep 15;86(6):836-43
Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.
Regan Anderson TM, Peacock DL, Daniel AR, Hubbard GK, Lofgren KA, Girard BJ, Schörg A, Hoogewijs D, Wenger RH, Seagroves TN, Lange CA
Cancer research 2013 Sep 15;73(18):5810-20
Cancer research 2013 Sep 15;73(18):5810-20
A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition.
Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton L, Lefai E, Simon MC, Maher JJ, Mithieux G, Rajas F, Annes J, McGuinness OP, Thurston G, Giaccia AJ, Kuo CJ
Nature medicine 2013 Oct;19(10):1331-1337
Nature medicine 2013 Oct;19(10):1331-1337
HIF isoforms in the skin differentially regulate systemic arterial pressure.
Cowburn AS, Takeda N, Boutin AT, Kim JW, Sterling JC, Nakasaki M, Southwood M, Goldrath AW, Jamora C, Nizet V, Chilvers ER, Johnson RS
Proceedings of the National Academy of Sciences of the United States of America 2013 Oct 22;110(43):17570-5
Proceedings of the National Academy of Sciences of the United States of America 2013 Oct 22;110(43):17570-5
Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways.
Selvarajah J, Nathawat K, Moumen A, Ashcroft M, Carroll VA
Cell death & disease 2013 Oct 17;4:e865
Cell death & disease 2013 Oct 17;4:e865
Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells.
Befani C, Mylonis I, Gkotinakou IM, Georgoulias P, Hu CJ, Simos G, Liakos P
The international journal of biochemistry & cell biology 2013 Nov;45(11):2359-68
The international journal of biochemistry & cell biology 2013 Nov;45(11):2359-68
Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen.
Doedens AL, Phan AT, Stradner MH, Fujimoto JK, Nguyen JV, Yang E, Johnson RS, Goldrath AW
Nature immunology 2013 Nov;14(11):1173-82
Nature immunology 2013 Nov;14(11):1173-82
Regulation of IL-1β-induced NF-κB by hydroxylases links key hypoxic and inflammatory signaling pathways.
Scholz CC, Cavadas MA, Tambuwala MM, Hams E, Rodríguez J, von Kriegsheim A, Cotter P, Bruning U, Fallon PG, Cheong A, Cummins EP, Taylor CT
Proceedings of the National Academy of Sciences of the United States of America 2013 Nov 12;110(46):18490-5
Proceedings of the National Academy of Sciences of the United States of America 2013 Nov 12;110(46):18490-5
Hypoxia-inducible factor-2α and TGF-β signaling interact to promote normoxic glomerular fibrogenesis.
Hanna C, Hubchak SC, Liang X, Rozen-Zvi B, Schumacker PT, Hayashida T, Schnaper HW
American journal of physiology. Renal physiology 2013 Nov 1;305(9):F1323-31
American journal of physiology. Renal physiology 2013 Nov 1;305(9):F1323-31
Silencing of GLUT-1 inhibits sensitization of oral cancer cells to cisplatin during hypoxia.
Shimanishi M, Ogi K, Sogabe Y, Kaneko T, Dehari H, Miyazaki A, Hiratsuka H
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2013 May;42(5):382-8
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2013 May;42(5):382-8
Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis.
Gilkes DM, Bajpai S, Wong CC, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL
Molecular cancer research : MCR 2013 May;11(5):456-66
Molecular cancer research : MCR 2013 May;11(5):456-66
Activation of HIF2α in kidney proximal tubule cells causes abnormal glycogen deposition but not tumorigenesis.
Fu L, Wang G, Shevchuk MM, Nanus DM, Gudas LJ
Cancer research 2013 May 1;73(9):2916-25
Cancer research 2013 May 1;73(9):2916-25
The protein tyrosine phosphatase receptor type J is regulated by the pVHL-HIF axis in clear cell renal cell carcinoma.
Casagrande S, Ruf M, Rechsteiner M, Morra L, Brun-Schmid S, von Teichman A, Krek W, Schraml P, Moch H
The Journal of pathology 2013 Mar;229(4):525-34
The Journal of pathology 2013 Mar;229(4):525-34
HIF2A and IGF2 expression correlates in human neuroblastoma cells and normal immature sympathetic neuroblasts.
Mohlin S, Hamidian A, Påhlman S
Neoplasia (New York, N.Y.) 2013 Mar;15(3):328-34
Neoplasia (New York, N.Y.) 2013 Mar;15(3):328-34
HIF2A and IGF2 expression correlates in human neuroblastoma cells and normal immature sympathetic neuroblasts.
Mohlin S, Hamidian A, Påhlman S
Neoplasia (New York, N.Y.) 2013 Mar;15(3):328-34
Neoplasia (New York, N.Y.) 2013 Mar;15(3):328-34
Stabilization of HIF-2α through redox regulation of mTORC2 activation and initiation of mRNA translation.
Nayak BK, Feliers D, Sudarshan S, Friedrichs WE, Day RT, New DD, Fitzgerald JP, Eid A, Denapoli T, Parekh DJ, Gorin Y, Block K
Oncogene 2013 Jun 27;32(26):3147-55
Oncogene 2013 Jun 27;32(26):3147-55
Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling.
Ikeda J, Ichiki T, Matsuura H, Inoue E, Kishimoto J, Watanabe A, Sankoda C, Kitamoto S, Tokunou T, Takeda K, Fong GH, Sunagawa K
Journal of the American Heart Association 2013 Jun 18;2(3):e000178
Journal of the American Heart Association 2013 Jun 18;2(3):e000178
Collagen prolyl hydroxylases are essential for breast cancer metastasis.
Gilkes DM, Chaturvedi P, Bajpai S, Wong CC, Wei H, Pitcairn S, Hubbi ME, Wirtz D, Semenza GL
Cancer research 2013 Jun 1;73(11):3285-96
Cancer research 2013 Jun 1;73(11):3285-96
CDH5 is specifically activated in glioblastoma stemlike cells and contributes to vasculogenic mimicry induced by hypoxia.
Mao XG, Xue XY, Wang L, Zhang X, Yan M, Tu YY, Lin W, Jiang XF, Ren HG, Zhang W, Song SJ
Neuro-oncology 2013 Jul;15(7):865-79
Neuro-oncology 2013 Jul;15(7):865-79
Sirtuin-7 inhibits the activity of hypoxia-inducible factors.
Hubbi ME, Hu H, Kshitiz, Gilkes DM, Semenza GL
The Journal of biological chemistry 2013 Jul 19;288(29):20768-75
The Journal of biological chemistry 2013 Jul 19;288(29):20768-75
Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice.
Chiabrando D, Fiorito V, Marro S, Silengo L, Altruda F, Tolosano E
Blood cells, molecules & diseases 2013 Jan;50(1):25-30
Blood cells, molecules & diseases 2013 Jan;50(1):25-30
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer.
Vanharanta S, Shu W, Brenet F, Hakimi AA, Heguy A, Viale A, Reuter VE, Hsieh JJ, Scandura JM, Massagué J
Nature medicine 2013 Jan;19(1):50-6
Nature medicine 2013 Jan;19(1):50-6
The accumulations of HIF-1α and HIF-2α by JNK and ERK are involved in biphasic effects induced by different levels of arsenite in human bronchial epithelial cells.
Xu Y, Li Y, Li H, Pang Y, Zhao Y, Jiang R, Shen L, Zhou J, Wang X, Liu Q
Toxicology and applied pharmacology 2013 Jan 15;266(2):187-97
Toxicology and applied pharmacology 2013 Jan 15;266(2):187-97
Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients.
Emerling BM, Benes CH, Poulogiannis G, Bell EL, Courtney K, Liu H, Choo-Wing R, Bellinger G, Tsukazawa KS, Brown V, Signoretti S, Soltoff SP, Cantley LC
Proceedings of the National Academy of Sciences of the United States of America 2013 Feb 26;110(9):3483-8
Proceedings of the National Academy of Sciences of the United States of America 2013 Feb 26;110(9):3483-8
Adaptation of iron transport and metabolism to acute high-altitude hypoxia in mountaineers.
Goetze O, Schmitt J, Spliethoff K, Theurl I, Weiss G, Swinkels DW, Tjalsma H, Maggiorini M, Krayenbühl P, Rau M, Fruehauf H, Wojtal KA, Müllhaupt B, Fried M, Gassmann M, Lutz T, Geier A
Hepatology (Baltimore, Md.) 2013 Dec;58(6):2153-62
Hepatology (Baltimore, Md.) 2013 Dec;58(6):2153-62
Regulation of the Hif-system by micro-RNA 17 and 20a - role during monocyte-to-macrophage differentiation.
Poitz DM, Augstein A, Gradehand C, Ende G, Schmeisser A, Strasser RH
Molecular immunology 2013 Dec;56(4):442-51
Molecular immunology 2013 Dec;56(4):442-51
Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis.
Glover LE, Bowers BE, Saeedi B, Ehrentraut SF, Campbell EL, Bayless AJ, Dobrinskikh E, Kendrick AA, Kelly CJ, Burgess A, Miller L, Kominsky DJ, Jedlicka P, Colgan SP
Proceedings of the National Academy of Sciences of the United States of America 2013 Dec 3;110(49):19820-5
Proceedings of the National Academy of Sciences of the United States of America 2013 Dec 3;110(49):19820-5
Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.
Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA
Cell 2013 Dec 19;155(7):1624-38
Cell 2013 Dec 19;155(7):1624-38
Integrated molecular analysis of clear-cell renal cell carcinoma.
Sato Y, Yoshizato T, Shiraishi Y, Maekawa S, Okuno Y, Kamura T, Shimamura T, Sato-Otsubo A, Nagae G, Suzuki H, Nagata Y, Yoshida K, Kon A, Suzuki Y, Chiba K, Tanaka H, Niida A, Fujimoto A, Tsunoda T, Morikawa T, Maeda D, Kume H, Sugano S, Fukayama M, Aburatani H, Sanada M, Miyano S, Homma Y, Ogawa S
Nature genetics 2013 Aug;45(8):860-7
Nature genetics 2013 Aug;45(8):860-7
Activation of hypoxia response in endothelial cells contributes to ischemic cardioprotection.
Kerkelä R, Karsikas S, Szabo Z, Serpi R, Magga J, Gao E, Alitalo K, Anisimov A, Sormunen R, Pietilä I, Vainio L, Koch WJ, Kivirikko KI, Myllyharju J, Koivunen P
Molecular and cellular biology 2013 Aug;33(16):3321-9
Molecular and cellular biology 2013 Aug;33(16):3321-9
Hypoxia-inducible factor (HIF)-1α suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction.
Storti P, Bolzoni M, Donofrio G, Airoldi I, Guasco D, Toscani D, Martella E, Lazzaretti M, Mancini C, Agnelli L, Patrene K, Maïga S, Franceschi V, Colla S, Anderson J, Neri A, Amiot M, Aversa F, Roodman GD, Giuliani N
Leukemia 2013 Aug;27(8):1697-706
Leukemia 2013 Aug;27(8):1697-706
Erythropoietin is a hypoxia inducible factor-induced protective molecule in experimental autoimmune neuritis.
Luo B, Jiang M, Yang X, Zhang Z, Xiong J, Schluesener HJ, Zhang Z, Wu Y
Biochimica et biophysica acta 2013 Aug;1832(8):1260-70
Biochimica et biophysica acta 2013 Aug;1832(8):1260-70
NF-κB inhibition by bortezomib permits IFN-γ-activated RIP1 kinase-dependent necrosis in renal cell carcinoma.
Thapa RJ, Chen P, Cheung M, Nogusa S, Pei J, Peri S, Testa JR, Balachandran S
Molecular cancer therapeutics 2013 Aug;12(8):1568-78
Molecular cancer therapeutics 2013 Aug;12(8):1568-78
IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation.
Wilkinson N, Pantopoulos K
Blood 2013 Aug 29;122(9):1658-68
Blood 2013 Aug 29;122(9):1658-68
Transcription factors Sp1 and Hif2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epithelial cells during hypoxia.
Xie L, Collins JF
The Journal of biological chemistry 2013 Aug 16;288(33):23943-52
The Journal of biological chemistry 2013 Aug 16;288(33):23943-52
Expression of VHL Causes Three-Dimensional Morphological Changes in Renal Cells Indicative of Proximal Tubule Differentiation.
Chiatar SS, Eze OP, Schoenfeld AR
Cell & developmental biology 2013 Aug 12;2
Cell & developmental biology 2013 Aug 12;2
Positive feedback loop and synergistic effects between hypoxia-inducible factor-2α and stearoyl-CoA desaturase-1 promote tumorigenesis in clear cell renal cell carcinoma.
Zhang Y, Wang H, Zhang J, Lv J, Huang Y
Cancer science 2013 Apr;104(4):416-22
Cancer science 2013 Apr;104(4):416-22
Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts.
Gilkes DM, Bajpai S, Chaturvedi P, Wirtz D, Semenza GL
The Journal of biological chemistry 2013 Apr 12;288(15):10819-29
The Journal of biological chemistry 2013 Apr 12;288(15):10819-29
The inhibition of HIF-2α on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation.
Pang Y, Xu Y, Li H, Li Y, Zhao Y, Jiang R, Shen L, Zhou J, Wang X, Liu Q
Toxicology letters 2013 Apr 12;218(2):105-17
Toxicology letters 2013 Apr 12;218(2):105-17
Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential.
Salnikov AV, Liu L, Platen M, Gladkich J, Salnikova O, Ryschich E, Mattern J, Moldenhauer G, Werner J, Schemmer P, Büchler MW, Herr I
PloS one 2012;7(9):e46391
PloS one 2012;7(9):e46391
Hypoxia regulates CD44 and its variant isoforms through HIF-1α in triple negative breast cancer.
Krishnamachary B, Penet MF, Nimmagadda S, Mironchik Y, Raman V, Solaiyappan M, Semenza GL, Pomper MG, Bhujwalla ZM
PloS one 2012;7(8):e44078
PloS one 2012;7(8):e44078
Suppression of glioma progression by Egln3.
Sciorra VA, Sanchez MA, Kunibe A, Wurmser AE
PloS one 2012;7(8):e40053
PloS one 2012;7(8):e40053
EMT and stem cell-like properties associated with HIF-2α are involved in arsenite-induced transformation of human bronchial epithelial cells.
Xu Y, Li Y, Pang Y, Ling M, Shen L, Yang X, Zhang J, Zhou J, Wang X, Liu Q
PloS one 2012;7(5):e37765
PloS one 2012;7(5):e37765
L-2-Oxothiazolidine-4-carboxylic acid or α-lipoic acid attenuates airway remodeling: involvement of nuclear factor-κB (NF-κB), nuclear factor erythroid 2p45-related factor-2 (Nrf2), and hypoxia-inducible factor (HIF).
Park SJ, Lee KS, Lee SJ, Kim SR, Park SY, Jeon MS, Lee HB, Lee YC
International journal of molecular sciences 2012;13(7):7915-37
International journal of molecular sciences 2012;13(7):7915-37
Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF.
Lee SW, Jeong HK, Lee JY, Yang J, Lee EJ, Kim SY, Youn SW, Lee J, Kim WJ, Kim KW, Lim JM, Park JW, Park YB, Kim HS
EMBO molecular medicine 2012 Sep;4(9):924-38
EMBO molecular medicine 2012 Sep;4(9):924-38
Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release.
Hatano N, Itoh Y, Suzuki H, Muraki Y, Hayashi H, Onozaki K, Wood IC, Beech DJ, Muraki K
The Journal of biological chemistry 2012 Sep 14;287(38):31962-72
The Journal of biological chemistry 2012 Sep 14;287(38):31962-72
Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C.
Kuzmanov A, Wielockx B, Rezaei M, Kettelhake A, Breier G
International journal of cancer 2012 Sep 1;131(5):E603-13
International journal of cancer 2012 Sep 1;131(5):E603-13
Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells.
Chiavarina B, Martinez-Outschoorn UE, Whitaker-Menezes D, Howell A, Tanowitz HB, Pestell RG, Sotgia F, Lisanti MP
Cell cycle (Georgetown, Tex.) 2012 Sep 1;11(17):3280-9
Cell cycle (Georgetown, Tex.) 2012 Sep 1;11(17):3280-9
AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma.
Park SJ, Lee KS, Kim SR, Chae HJ, Yoo WH, Kim DI, Jeon MS, Lee YC
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2012 Oct;61(10):1069-83
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2012 Oct;61(10):1069-83
The hypoxia-inducible factor-C/EBPα axis controls ethanol-mediated hepcidin repression.
Anderson ER, Taylor M, Xue X, Martin A, Moons DS, Omary MB, Shah YM
Molecular and cellular biology 2012 Oct;32(19):4068-77
Molecular and cellular biology 2012 Oct;32(19):4068-77
Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma.
Croci DO, Salatino M, Rubinstein N, Cerliani JP, Cavallin LE, Leung HJ, Ouyang J, Ilarregui JM, Toscano MA, Domaica CI, Croci MC, Shipp MA, Mesri EA, Albini A, Rabinovich GA
The Journal of experimental medicine 2012 Oct 22;209(11):1985-2000
The Journal of experimental medicine 2012 Oct 22;209(11):1985-2000
Upstream stimulatory factor 2 and hypoxia-inducible factor 2α (HIF2α) cooperatively activate HIF2 target genes during hypoxia.
Pawlus MR, Wang L, Ware K, Hu CJ
Molecular and cellular biology 2012 Nov;32(22):4595-610
Molecular and cellular biology 2012 Nov;32(22):4595-610
Tumor microvasculature with endothelial fenestrations in VHL null clear cell renal cell carcinomas as a potent target of anti-angiogenic therapy.
Yamasaki T, Kamba T, Kanno T, Inoue T, Shibasaki N, Arakaki R, Yamada T, Kondo K, Kamoto T, Nishiyama H, Ogawa O, Nakamura E
Cancer science 2012 Nov;103(11):2027-37
Cancer science 2012 Nov;103(11):2027-37
Co-expression of XIAP and cyclin D1 complex correlates with a poor prognosis in patients with hepatocellular carcinoma.
Che Y, Ye F, Xu R, Qing H, Wang X, Yin F, Cui M, Burstein D, Jiang B, Zhang DY
The American journal of pathology 2012 May;180(5):1798-807
The American journal of pathology 2012 May;180(5):1798-807
Effects of oxygen on zonal marker expression in human articular chondrocytes.
Schrobback K, Malda J, Crawford RW, Upton Z, Leavesley DI, Klein TJ
Tissue engineering. Part A 2012 May;18(9-10):920-33
Tissue engineering. Part A 2012 May;18(9-10):920-33
An oxygen-regulated switch in the protein synthesis machinery.
Uniacke J, Holterman CE, Lachance G, Franovic A, Jacob MD, Fabian MR, Payette J, Holcik M, Pause A, Lee S
Nature 2012 May 6;486(7401):126-9
Nature 2012 May 6;486(7401):126-9
Knockdown of von Hippel-Lindau protein decreases lung cancer cell proliferation and colonization.
Zhou Q, Chen T, Ibe JC, Raj JU, Zhou G
FEBS letters 2012 May 21;586(10):1510-5
FEBS letters 2012 May 21;586(10):1510-5
Chronic nicotine induces hypoxia inducible factor-2α in perinatal rat adrenal chromaffin cells: role in transcriptional upregulation of KATP channel subunit Kir6.2.
Salman S, Brown ST, Nurse CA
American journal of physiology. Cell physiology 2012 May 15;302(10):C1531-8
American journal of physiology. Cell physiology 2012 May 15;302(10):C1531-8
Heat shock transcription factor Hsf1 is involved in tumor progression via regulation of hypoxia-inducible factor 1 and RNA-binding protein HuR.
Gabai VL, Meng L, Kim G, Mills TA, Benjamin IJ, Sherman MY
Molecular and cellular biology 2012 Mar;32(5):929-40
Molecular and cellular biology 2012 Mar;32(5):929-40
Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction.
Ryu JH, Shin Y, Huh YH, Yang S, Chun CH, Chun JS
Cell death and differentiation 2012 Mar;19(3):440-50
Cell death and differentiation 2012 Mar;19(3):440-50
Hypoxia-induced mixed-lineage leukemia 1 regulates glioma stem cell tumorigenic potential.
Heddleston JM, Wu Q, Rivera M, Minhas S, Lathia JD, Sloan AE, Iliopoulos O, Hjelmeland AB, Rich JN
Cell death and differentiation 2012 Mar;19(3):428-39
Cell death and differentiation 2012 Mar;19(3):428-39
The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO.
Rankin EB, Wu C, Khatri R, Wilson TL, Andersen R, Araldi E, Rankin AL, Yuan J, Kuo CJ, Schipani E, Giaccia AJ
Cell 2012 Mar 30;149(1):63-74
Cell 2012 Mar 30;149(1):63-74
Blockade of p53 by HIF-2α, but not HIF-1α, is involved in arsenite-induced malignant transformation of human bronchial epithelial cells.
Xu Y, Li Y, Pang Y, Ling M, Shen L, Jiang R, Zhao Y, Zhou J, Wang X, Liu Q
Archives of toxicology 2012 Jun;86(6):947-59
Archives of toxicology 2012 Jun;86(6):947-59
Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1α-mediated mRNA transcription and continuous protein synthesis.
Natsuizaka M, Naganuma S, Kagawa S, Ohashi S, Ahmadi A, Subramanian H, Chang S, Nakagawa KJ, Ji X, Liebhaber SA, Klein-Szanto AJ, Nakagawa H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Jun;26(6):2620-30
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012 Jun;26(6):2620-30
Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis.
Ding Z, German P, Bai S, Feng Z, Gao M, Si W, Sobieski MM, Stephan CC, Mills GB, Jonasch E
Journal of biomolecular screening 2012 Jun;17(5):572-80
Journal of biomolecular screening 2012 Jun;17(5):572-80
Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma.
Boysen G, Bausch-Fluck D, Thoma CR, Nowicka AM, Stiehl DP, Cima I, Luu VD, von Teichman A, Hermanns T, Sulser T, Ingold-Heppner B, Fankhauser N, Wenger RH, Krek W, Schraml P, Wollscheid B, Moch H
Neoplasia (New York, N.Y.) 2012 Jun;14(6):535-46
Neoplasia (New York, N.Y.) 2012 Jun;14(6):535-46
Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma.
Boysen G, Bausch-Fluck D, Thoma CR, Nowicka AM, Stiehl DP, Cima I, Luu VD, von Teichman A, Hermanns T, Sulser T, Ingold-Heppner B, Fankhauser N, Wenger RH, Krek W, Schraml P, Wollscheid B, Moch H
Neoplasia (New York, N.Y.) 2012 Jun;14(6):535-46
Neoplasia (New York, N.Y.) 2012 Jun;14(6):535-46
JunB promotes cell invasion and angiogenesis in VHL-defective renal cell carcinoma.
Kanno T, Kamba T, Yamasaki T, Shibasaki N, Saito R, Terada N, Toda Y, Mikami Y, Inoue T, Kanematsu A, Nishiyama H, Ogawa O, Nakamura E
Oncogene 2012 Jun 21;31(25):3098-110
Oncogene 2012 Jun 21;31(25):3098-110
Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis.
Qi Y, Tian X, Liu J, Han Y, Graham AM, Simon MC, Penninger JM, Carmeliet P, Li S
The Journal of cell biology 2012 Jul 9;198(1):103-14
The Journal of cell biology 2012 Jul 9;198(1):103-14
Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2α.
Pourvali K, Matak P, Latunde-Dada GO, Solomou S, Mastrogiannaki M, Peyssonnaux C, Sharp PA
FEBS letters 2012 Jul 30;586(16):2423-7
FEBS letters 2012 Jul 30;586(16):2423-7
Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition.
Chintala S, Najrana T, Toth K, Cao S, Durrani FA, Pili R, Rustum YM
BMC cancer 2012 Jul 17;12:293
BMC cancer 2012 Jul 17;12:293
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induction by hypoxia and hypoxia-inducible factors.
Veeranna RP, Haque M, Davis DA, Yang M, Yarchoan R
Journal of virology 2012 Jan;86(2):1097-108
Journal of virology 2012 Jan;86(2):1097-108
Hypoxia-inducible factor-1 (HIF-1) promotes LDL and VLDL uptake through inducing VLDLR under hypoxia.
Shen GM, Zhao YZ, Chen MT, Zhang FL, Liu XL, Wang Y, Liu CZ, Yu J, Zhang JW
The Biochemical journal 2012 Jan 15;441(2):675-83
The Biochemical journal 2012 Jan 15;441(2):675-83
Hypoxia modulates the undifferentiated phenotype of human renal inner medullary CD133+ progenitors through Oct4/miR-145 balance.
Bussolati B, Moggio A, Collino F, Aghemo G, D'Armento G, Grange C, Camussi G
American journal of physiology. Renal physiology 2012 Jan 1;302(1):F116-28
American journal of physiology. Renal physiology 2012 Jan 1;302(1):F116-28
Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1.
Hubbi ME, Gilkes DM, Baek JH, Semenza GL
The Journal of biological chemistry 2012 Feb 24;287(9):6139-49
The Journal of biological chemistry 2012 Feb 24;287(9):6139-49
Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element.
Xu J, Wang B, Xu Y, Sun L, Tian W, Shukla D, Barod R, Grillari J, Grillari-Voglauer R, Maxwell PH, Esteban MA
Oncogene 2012 Feb 23;31(8):1065-72
Oncogene 2012 Feb 23;31(8):1065-72
Antiangiogenic agents increase breast cancer stem cells via the generation of tumor hypoxia.
Conley SJ, Gheordunescu E, Kakarala P, Newman B, Korkaya H, Heath AN, Clouthier SG, Wicha MS
Proceedings of the National Academy of Sciences of the United States of America 2012 Feb 21;109(8):2784-9
Proceedings of the National Academy of Sciences of the United States of America 2012 Feb 21;109(8):2784-9
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
Koivunen P, Lee S, Duncan CG, Lopez G, Lu G, Ramkissoon S, Losman JA, Joensuu P, Bergmann U, Gross S, Travins J, Weiss S, Looper R, Ligon KL, Verhaak RG, Yan H, Kaelin WG Jr
Nature 2012 Feb 15;483(7390):484-8
Nature 2012 Feb 15;483(7390):484-8
Ultraviolet A regulates the stemness of human adipose tissue-derived mesenchymal stem cells through downregulation of the HIF-1α via activation of PGE(2)-cAMP signaling.
Lee J, Jung E, Hyun JW, Park D
Journal of cellular biochemistry 2012 Dec;113(12):3681-91
Journal of cellular biochemistry 2012 Dec;113(12):3681-91
Pseudolaric acid B-driven phosphorylation of c-Jun impairs its role in stabilizing HIF-1alpha: a novel function-converter model.
Yu B, Li MH, Wang W, Wang YQ, Jiang Y, Yang SP, Yue JM, Ding J, Miao ZH
Journal of molecular medicine (Berlin, Germany) 2012 Aug;90(8):971-81
Journal of molecular medicine (Berlin, Germany) 2012 Aug;90(8):971-81
Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism.
Bardella C, Olivero M, Lorenzato A, Geuna M, Adam J, O'Flaherty L, Rustin P, Tomlinson I, Pollard PJ, Di Renzo MF
Molecular and cellular biology 2012 Aug;32(15):3081-94
Molecular and cellular biology 2012 Aug;32(15):3081-94
The acetylase/deacetylase couple CREB-binding protein/Sirtuin 1 controls hypoxia-inducible factor 2 signaling.
Chen R, Xu M, Hogg RT, Li J, Little B, Gerard RD, Garcia JA
The Journal of biological chemistry 2012 Aug 31;287(36):30800-11
The Journal of biological chemistry 2012 Aug 31;287(36):30800-11
Functional importance of Dicer protein in the adaptive cellular response to hypoxia.
Ho JJ, Metcalf JL, Yan MS, Turgeon PJ, Wang JJ, Chalsev M, Petruzziello-Pellegrini TN, Tsui AK, He JZ, Dhamko H, Man HS, Robb GB, Teh BT, Ohh M, Marsden PA
The Journal of biological chemistry 2012 Aug 17;287(34):29003-20
The Journal of biological chemistry 2012 Aug 17;287(34):29003-20
Hypoxia-mediated impairment of the mitochondrial respiratory chain inhibits the bactericidal activity of macrophages.
Wiese M, Gerlach RG, Popp I, Matuszak J, Mahapatro M, Castiglione K, Chakravortty D, Willam C, Hensel M, Bogdan C, Jantsch J
Infection and immunity 2012 Apr;80(4):1455-66
Infection and immunity 2012 Apr;80(4):1455-66
HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs.
Zhang H, Wong CC, Wei H, Gilkes DM, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary B, Winnard PT Jr, Raman V, Zhen L, Mitzner WA, Sukumar S, Semenza GL
Oncogene 2012 Apr 5;31(14):1757-70
Oncogene 2012 Apr 5;31(14):1757-70
Prostate cancer cell lines under hypoxia exhibit greater stem-like properties.
Ma Y, Liang D, Liu J, Axcrona K, Kvalheim G, Stokke T, Nesland JM, Suo Z
PloS one 2011;6(12):e29170
PloS one 2011;6(12):e29170
Assessment of hypoxia inducible factor levels in cancer cell lines upon hypoxic induction using a novel reporter construct.
Zhou W, Dosey TL, Biechele T, Moon RT, Horwitz MS, Ruohola-Baker H
PloS one 2011;6(11):e27460
PloS one 2011;6(11):e27460
Multidimensional poverty and child survival in India.
Mohanty SK
PloS one 2011;6(10):e26857
PloS one 2011;6(10):e26857
OxLDL and macrophage survival: essential and oxygen-independent involvement of the Hif-pathway.
Poitz DM, Augstein A, Weinert S, Braun-Dullaeus RC, Strasser RH, Schmeisser A
Basic research in cardiology 2011 Sep;106(5):761-72
Basic research in cardiology 2011 Sep;106(5):761-72
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation.
Wong CC, Gilkes DM, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, Wirtz D, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2011 Sep 27;108(39):16369-74
Proceedings of the National Academy of Sciences of the United States of America 2011 Sep 27;108(39):16369-74
Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2α through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms.
Higashimura Y, Terai T, Yamaji R, Mitani T, Ogawa M, Harada N, Inui H, Nakano Y
Biochemical and biophysical research communications 2011 Sep 23;413(2):201-5
Biochemical and biophysical research communications 2011 Sep 23;413(2):201-5
Chronic hypoxia upregulates adenosine 2a receptor expression in chromaffin cells via hypoxia inducible factor-2α: role in modulating secretion.
Brown ST, Reyes EP, Nurse CA
Biochemical and biophysical research communications 2011 Sep 2;412(3):466-72
Biochemical and biophysical research communications 2011 Sep 2;412(3):466-72
MicroRNA-155 promotes resolution of hypoxia-inducible factor 1alpha activity during prolonged hypoxia.
Bruning U, Cerone L, Neufeld Z, Fitzpatrick SF, Cheong A, Scholz CC, Simpson DA, Leonard MO, Tambuwala MM, Cummins EP, Taylor CT
Molecular and cellular biology 2011 Oct;31(19):4087-96
Molecular and cellular biology 2011 Oct;31(19):4087-96
Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia.
Tsui AK, Marsden PA, Mazer CD, Adamson SL, Henkelman RM, Ho JJ, Wilson DF, Heximer SP, Connelly KA, Bolz SS, Lidington D, El-Beheiry MH, Dattani ND, Chen KM, Hare GM
Proceedings of the National Academy of Sciences of the United States of America 2011 Oct 18;108(42):17544-9
Proceedings of the National Academy of Sciences of the United States of America 2011 Oct 18;108(42):17544-9
Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis.
Monzon FA, Alvarez K, Peterson L, Truong L, Amato RJ, Hernandez-McClain J, Tannir N, Parwani AV, Jonasch E
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011 Nov;24(11):1470-9
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011 Nov;24(11):1470-9
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia.
Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G
Nature 2011 Nov 20;481(7381):380-4
Nature 2011 Nov 20;481(7381):380-4
Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice.
Farrow EG, Yu X, Summers LJ, Davis SI, Fleet JC, Allen MR, Robling AG, Stayrook KR, Jideonwo V, Magers MJ, Garringer HJ, Vidal R, Chan RJ, Goodwin CB, Hui SL, Peacock M, White KE
Proceedings of the National Academy of Sciences of the United States of America 2011 Nov 15;108(46):E1146-55
Proceedings of the National Academy of Sciences of the United States of America 2011 Nov 15;108(46):E1146-55
Normoxic expression of hypoxia-inducible factor 1 in rat Leydig cells in vivo and in vitro.
Palladino MA, Pirlamarla PR, McNamara J, Sottas CM, Korah N, Hardy MP, Hales DB, Hermo L
Journal of andrology 2011 May-Jun;32(3):307-23
Journal of andrology 2011 May-Jun;32(3):307-23
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.
Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL
Cell 2011 May 27;145(5):732-44
Cell 2011 May 27;145(5):732-44
A novel specific application of pyruvate protects the mouse retina against white light damage: differential stabilization of HIF-1α and HIF-2α.
Ren H, Liu NY, Song XF, Ma YS, Zhai XY
Investigative ophthalmology & visual science 2011 May 11;52(6):3112-8
Investigative ophthalmology & visual science 2011 May 11;52(6):3112-8
Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells.
Higashimura Y, Nakajima Y, Yamaji R, Harada N, Shibasaki F, Nakano Y, Inui H
Archives of biochemistry and biophysics 2011 May 1;509(1):1-8
Archives of biochemistry and biophysics 2011 May 1;509(1):1-8
NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning.
Valsecchi V, Pignataro G, Del Prete A, Sirabella R, Matrone C, Boscia F, Scorziello A, Sisalli MJ, Esposito E, Zambrano N, Di Renzo G, Annunziato L
Stroke 2011 Mar;42(3):754-63
Stroke 2011 Mar;42(3):754-63
Captopril modulates hypoxia-inducible factors and erythropoietin responses in a murine model of total body irradiation.
Barshishat-Kupper M, Mungunsukh O, Tipton AJ, McCart EA, Panganiban RA, Davis TA, Landauer MR, Day RM
Experimental hematology 2011 Mar;39(3):293-304
Experimental hematology 2011 Mar;39(3):293-304
Transcriptional regulation of the Menkes copper ATPase (Atp7a) gene by hypoxia-inducible factor (HIF2{alpha}) in intestinal epithelial cells.
Xie L, Collins JF
American journal of physiology. Cell physiology 2011 Jun;300(6):C1298-305
American journal of physiology. Cell physiology 2011 Jun;300(6):C1298-305
Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia.
Russell RC, Sufan RI, Zhou B, Heir P, Bunda S, Sybingco SS, Greer SN, Roche O, Heathcote SA, Chow VW, Boba LM, Richmond TD, Hickey MM, Barber DL, Cheresh DA, Simon MC, Irwin MS, Kim WY, Ohh M
Nature medicine 2011 Jun 19;17(7):845-53
Nature medicine 2011 Jun 19;17(7):845-53
Lack of iron-related phenotype in Sp6 intestinal knockout mice.
Matak P, Deschemin JC, Peyssonnaux C, Vaulont S
Blood cells, molecules & diseases 2011 Jun 15;47(1):46-9
Blood cells, molecules & diseases 2011 Jun 15;47(1):46-9
MCM proteins are negative regulators of hypoxia-inducible factor 1.
Hubbi ME, Luo W, Baek JH, Semenza GL
Molecular cell 2011 Jun 10;42(5):700-12
Molecular cell 2011 Jun 10;42(5):700-12
The hypoxia-associated factor switches cells from HIF-1α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion.
Koh MY, Lemos R Jr, Liu X, Powis G
Cancer research 2011 Jun 1;71(11):4015-27
Cancer research 2011 Jun 1;71(11):4015-27
Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation.
Zhang H, Zhang G, Gonzalez FJ, Park SM, Cai D
PLoS biology 2011 Jul;9(7):e1001112
PLoS biology 2011 Jul;9(7):e1001112
Normoxic activation of hypoxia-inducible factors in photoreceptors provides transient protection against light-induced retinal degeneration.
Lange C, Heynen SR, Tanimoto N, Thiersch M, Le YZ, Meneau I, Seeliger MW, Samardzija M, Caprara C, Grimm C
Investigative ophthalmology & visual science 2011 Jul 29;52(8):5872-80
Investigative ophthalmology & visual science 2011 Jul 29;52(8):5872-80
Retina-specific activation of a sustained hypoxia-like response leads to severe retinal degeneration and loss of vision.
Lange C, Caprara C, Tanimoto N, Beck S, Huber G, Samardzija M, Seeliger M, Grimm C
Neurobiology of disease 2011 Jan;41(1):119-30
Neurobiology of disease 2011 Jan;41(1):119-30
Immunohistochemical basis for adjuvant anti-angiogenic targeted therapy for renal carcinoid: initial case report.
Finley DS, Narula N, Valera VA, Merino MJ, Fruehauf J, Wu ML, Linehan WM, Clayman RV
Urologic oncology 2011 Jan-Feb;29(1):85-9
Urologic oncology 2011 Jan-Feb;29(1):85-9
Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells.
Place TL, Fitzgerald MP, Venkataraman S, Vorrink SU, Case AJ, Teoh ML, Domann FE
PloS one 2011 Jan 28;6(1):e14617
PloS one 2011 Jan 28;6(1):e14617
Evolutionary conserved regulation of HIF-1β by NF-κB.
van Uden P, Kenneth NS, Webster R, Müller HA, Mudie S, Rocha S
PLoS genetics 2011 Jan 27;7(1):e1001285
PLoS genetics 2011 Jan 27;7(1):e1001285
Hypoxia-inducible factor-1α regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis.
Copple BL, Bai S, Burgoon LD, Moon JO
Liver international : official journal of the International Association for the Study of the Liver 2011 Feb;31(2):230-44
Liver international : official journal of the International Association for the Study of the Liver 2011 Feb;31(2):230-44
Oxygen regulation of the epithelial Na channel in the collecting duct.
Husted RF, Lu H, Sigmund RD, Stokes JB
American journal of physiology. Renal physiology 2011 Feb;300(2):F412-24
American journal of physiology. Renal physiology 2011 Feb;300(2):F412-24
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension.
Peng YJ, Nanduri J, Khan SA, Yuan G, Wang N, Kinsman B, Vaddi DR, Kumar GK, Garcia JA, Semenza GL, Prabhakar NR
Proceedings of the National Academy of Sciences of the United States of America 2011 Feb 15;108(7):3065-70
Proceedings of the National Academy of Sciences of the United States of America 2011 Feb 15;108(7):3065-70
VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration.
Razorenova OV, Finger EC, Colavitti R, Chernikova SB, Boiko AD, Chan CK, Krieg A, Bedogni B, LaGory E, Weissman IL, Broome-Powell M, Giaccia AJ
Proceedings of the National Academy of Sciences of the United States of America 2011 Feb 1;108(5):1931-6
Proceedings of the National Academy of Sciences of the United States of America 2011 Feb 1;108(5):1931-6
Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice.
Sakoda Y, Anand S, Zhao Y, Park JJ, Liu Y, Kuramasu A, van Rooijen N, Chen L, Strome SE, Hancock WW, Chen L, Tamada K
The Journal of clinical investigation 2011 Dec;121(12):4810-9
The Journal of clinical investigation 2011 Dec;121(12):4810-9
Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation.
Bohonowych JE, Peng S, Gopal U, Hance MW, Wing SB, Argraves KM, Lundgren K, Isaacs JS
BMC cancer 2011 Dec 15;11:520
BMC cancer 2011 Dec 15;11:520
Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis.
Lee SJ, Kim HP, Jin Y, Choi AM, Ryter SW
Autophagy 2011 Aug;7(8):829-39
Autophagy 2011 Aug;7(8):829-39
Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis.
Lee SJ, Kim HP, Jin Y, Choi AM, Ryter SW
Autophagy 2011 Aug;7(8):829-39
Autophagy 2011 Aug;7(8):829-39
Association of elevated HIF-2α levels with low Beclin 1 expression and poor prognosis in patients with chondrosarcoma.
Chen C, Ma Q, Ma X, Liu Z, Liu X
Annals of surgical oncology 2011 Aug;18(8):2364-72
Annals of surgical oncology 2011 Aug;18(8):2364-72
Crocidolite asbestos-induced signal pathway dysregulation in mesothelial cells.
Wang H, Gillis A, Zhao C, Lee E, Wu J, Zhang F, Ye F, Zhang DY
Mutation research 2011 Aug 16;723(2):171-6
Mutation research 2011 Aug 16;723(2):171-6
New role for granulocyte colony-stimulating factor-induced extracellular signal-regulated kinase 1/2 in histone modification and retinoic acid receptor α recruitment to gene promoters: relevance to acute promyelocytic leukemia cell differentiation.
Cassinat B, Zassadowski F, Ferry C, Llopis L, Bruck N, Lainey E, Duong V, Cras A, Despouy G, Chourbagi O, Beinse G, Fenaux P, Rochette Egly C, Chomienne C
Molecular and cellular biology 2011 Apr;31(7):1409-18
Molecular and cellular biology 2011 Apr;31(7):1409-18
Prolyl hydroxylase domain protein 2 (PHD2) mediates oxygen-induced retinopathy in neonatal mice.
Duan LJ, Takeda K, Fong GH
The American journal of pathology 2011 Apr;178(4):1881-90
The American journal of pathology 2011 Apr;178(4):1881-90
Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma.
Jham BC, Ma T, Hu J, Chaisuparat R, Friedman ER, Pandolfi PP, Schneider A, Sodhi A, Montaner S
PloS one 2011 Apr 29;6(4):e19103
PloS one 2011 Apr 29;6(4):e19103
HIF-2 directly activates CD82 gene expression in endothelial cells.
Nagao K, Oka K
Biochemical and biophysical research communications 2011 Apr 1;407(1):260-5
Biochemical and biophysical research communications 2011 Apr 1;407(1):260-5
Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy.
Moslehi J, Minamishima YA, Shi J, Neuberg D, Charytan DM, Padera RF, Signoretti S, Liao R, Kaelin WG Jr
Circulation 2010 Sep 7;122(10):1004-16
Circulation 2010 Sep 7;122(10):1004-16
Hypoxia induces PTHrP gene transcription in human cancer cells through the HIF-2α.
Manisterski M, Golan M, Amir S, Weisman Y, Mabjeesh NJ
Cell cycle (Georgetown, Tex.) 2010 Sep 15;9(18):3723-9
Cell cycle (Georgetown, Tex.) 2010 Sep 15;9(18):3723-9
Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion.
Terzuoli E, Puppo M, Rapisarda A, Uranchimeg B, Cao L, Burger AM, Ziche M, Melillo G
Cancer research 2010 Sep 1;70(17):6837-48
Cancer research 2010 Sep 1;70(17):6837-48
Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitis.
Pareek TK, Lam E, Zheng X, Askew D, Kulkarni AB, Chance MR, Huang AY, Cooke KR, Letterio JJ
The Journal of experimental medicine 2010 Oct 25;207(11):2507-19
The Journal of experimental medicine 2010 Oct 25;207(11):2507-19
The VHL-dependent regulation of microRNAs in renal cancer.
Neal CS, Michael MZ, Rawlings LH, Van der Hoek MB, Gleadle JM
BMC medicine 2010 Oct 21;8:64
BMC medicine 2010 Oct 21;8:64
Cross-species comparison of genomewide gene expression profiles reveals induction of hypoxia-inducible factor-responsive genes in iron-deprived intestinal epithelial cells.
Hu Z, Gulec S, Collins JF
American journal of physiology. Cell physiology 2010 Nov;299(5):C930-8
American journal of physiology. Cell physiology 2010 Nov;299(5):C930-8
Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1.
Gimm T, Wiese M, Teschemacher B, Deggerich A, Schödel J, Knaup KX, Hackenbeck T, Hellerbrand C, Amann K, Wiesener MS, Höning S, Eckardt KU, Warnecke C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Nov;24(11):4443-58
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Nov;24(11):4443-58
Hypoxia-inducible factor-2 is a novel regulator of aberrant CXCL12 expression in multiple myeloma plasma cells.
Martin SK, Diamond P, Williams SA, To LB, Peet DJ, Fujii N, Gronthos S, Harris AL, Zannettino AC
Haematologica 2010 May;95(5):776-84
Haematologica 2010 May;95(5):776-84
Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms.
Copple BL
Liver international : official journal of the International Association for the Study of the Liver 2010 May;30(5):669-82
Liver international : official journal of the International Association for the Study of the Liver 2010 May;30(5):669-82
COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion.
van de Sluis B, Mao X, Zhai Y, Groot AJ, Vermeulen JF, van der Wall E, van Diest PJ, Hofker MH, Wijmenga C, Klomp LW, Cho KR, Fearon ER, Vooijs M, Burstein E
The Journal of clinical investigation 2010 Jun;120(6):2119-30
The Journal of clinical investigation 2010 Jun;120(6):2119-30
Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia.
Wu DC, Paulson RF
PloS one 2010 Jun 24;5(6):e11303
PloS one 2010 Jun 24;5(6):e11303
The efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 compared with rapamycin in renal cell carcinoma.
Cho DC, Cohen MB, Panka DJ, Collins M, Ghebremichael M, Atkins MB, Signoretti S, Mier JW
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Jul 15;16(14):3628-38
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Jul 15;16(14):3628-38
Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth.
Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ
Molecular and cellular biology 2010 Jan;30(1):344-53
Molecular and cellular biology 2010 Jan;30(1):344-53
Molecular characterization of antibody epitopes of Ehrlichia chaffeensis ankyrin protein 200 and tandem repeat protein 47 and evaluation of synthetic immunodeterminants for serodiagnosis of human monocytotropic ehrlichiosis.
Luo T, Zhang X, Nicholson WL, Zhu B, McBride JW
Clinical and vaccine immunology : CVI 2010 Jan;17(1):87-97
Clinical and vaccine immunology : CVI 2010 Jan;17(1):87-97
Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors.
Henze AT, Riedel J, Diem T, Wenner J, Flamme I, Pouyseggur J, Plate KH, Acker T
Cancer research 2010 Jan 1;70(1):357-66
Cancer research 2010 Jan 1;70(1):357-66
Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.
Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza GL
The Journal of biological chemistry 2010 Feb 5;285(6):3651-63
The Journal of biological chemistry 2010 Feb 5;285(6):3651-63
Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1alpha.
Qing G, Skuli N, Mayes PA, Pawel B, Martinez D, Maris JM, Simon MC
Cancer research 2010 Dec 15;70(24):10351-61
Cancer research 2010 Dec 15;70(24):10351-61
PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types.
Rasbach KA, Gupta RK, Ruas JL, Wu J, Naseri E, Estall JL, Spiegelman BM
Proceedings of the National Academy of Sciences of the United States of America 2010 Dec 14;107(50):21866-71
Proceedings of the National Academy of Sciences of the United States of America 2010 Dec 14;107(50):21866-71
Fumarase tumor suppressor gene and MET oncogene cooperate in upholding transformation and tumorigenesis.
Costa B, Dettori D, Lorenzato A, Bardella C, Coltella N, Martino C, Cammarata C, Carmeliet P, Olivero M, Di Renzo MF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Aug;24(8):2680-8
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Aug;24(8):2680-8
RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha.
van Hagen M, Overmeer RM, Abolvardi SS, Vertegaal AC
Nucleic acids research 2010 Apr;38(6):1922-31
Nucleic acids research 2010 Apr;38(6):1922-31
The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2.
Zimmer M, Lamb J, Ebert BL, Lynch M, Neil C, Schmidt E, Golub TR, Iliopoulos O
Cancer research 2010 Apr 15;70(8):3071-9
Cancer research 2010 Apr 15;70(8):3071-9
Docosahexaenoic acid inhibits superoxide dismutase 1 gene transcription in human cancer cells: the involvement of peroxisome proliferator-activated receptor alpha and hypoxia-inducible factor-2alpha signaling.
Tuller ER, Beavers CT, Lou JR, Ihnat MA, Benbrook DM, Ding WQ
Molecular pharmacology 2009 Sep;76(3):588-95
Molecular pharmacology 2009 Sep;76(3):588-95
Disseminated pyoderma gangrenosum: role for vascular endothelial growth factor and hypoxia inducible factor-2.
Chua RA, Mackelfresh J, Cohen C, Varma V, Fried L, Arbiser JL
Journal of the American Academy of Dermatology 2009 Oct;61(4):730-2
Journal of the American Academy of Dermatology 2009 Oct;61(4):730-2
The human HIF (hypoxia-inducible factor)-3alpha gene is a HIF-1 target gene and may modulate hypoxic gene induction.
Tanaka T, Wiesener M, Bernhardt W, Eckardt KU, Warnecke C
The Biochemical journal 2009 Oct 23;424(1):143-51
The Biochemical journal 2009 Oct 23;424(1):143-51
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization.
Lee K, Zhang H, Qian DZ, Rey S, Liu JO, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2009 Oct 20;106(42):17910-5
Proceedings of the National Academy of Sciences of the United States of America 2009 Oct 20;106(42):17910-5
A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo.
Minamishima YA, Moslehi J, Padera RF, Bronson RT, Liao R, Kaelin WG Jr
Molecular and cellular biology 2009 Nov;29(21):5729-41
Molecular and cellular biology 2009 Nov;29(21):5729-41
Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability.
Przybytkowski E, Behrendt M, Dubois D, Maysinger D
The FEBS journal 2009 Nov;276(21):6204-17
The FEBS journal 2009 Nov;276(21):6204-17
Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons.
Lomb DJ, Desouza LA, Franklin JL, Freeman RS
Molecular pharmacology 2009 May;75(5):1198-209
Molecular pharmacology 2009 May;75(5):1198-209
Regulation of autophagy in human and murine cartilage: hypoxia-inducible factor 2 suppresses chondrocyte autophagy.
Bohensky J, Terkhorn SP, Freeman TA, Adams CS, Garcia JA, Shapiro IM, Srinivas V
Arthritis and rheumatism 2009 May;60(5):1406-15
Arthritis and rheumatism 2009 May;60(5):1406-15
Red wine polyphenols prevent acceleration of neovascularization by angiotensin II in the ischemic rat hindlimb.
Walter A, Etienne-Selloum N, Brasse D, Schleiffer R, Bekaert V, Vanhoutte PM, Beretz A, Schini-Kerth VB
The Journal of pharmacology and experimental therapeutics 2009 May;329(2):699-707
The Journal of pharmacology and experimental therapeutics 2009 May;329(2):699-707
HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury.
Schödel J, Klanke B, Weidemann A, Buchholz B, Bernhardt W, Bertog M, Amann K, Korbmacher C, Wiesener M, Warnecke C, Kurtz A, Eckardt KU, Willam C
The American journal of pathology 2009 May;174(5):1663-74
The American journal of pathology 2009 May;174(5):1663-74
HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice.
Mastrogiannaki M, Matak P, Keith B, Simon MC, Vaulont S, Peyssonnaux C
The Journal of clinical investigation 2009 May;119(5):1159-66
The Journal of clinical investigation 2009 May;119(5):1159-66
Loss of VHL and hypoxia provokes PAX2 up-regulation in clear cell renal cell carcinoma.
Luu VD, Boysen G, Struckmann K, Casagrande S, von Teichman A, Wild PJ, Sulser T, Schraml P, Moch H
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 May 15;15(10):3297-304
Clinical cancer research : an official journal of the American Association for Cancer Research 2009 May 15;15(10):3297-304
PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma.
Petrella BL, Brinckerhoff CE
Cancer biology & therapy 2009 Jul;8(14):1389-401
Cancer biology & therapy 2009 Jul;8(14):1389-401
PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma.
Petrella BL, Brinckerhoff CE
Cancer biology & therapy 2009 Jul;8(14):1389-401
Cancer biology & therapy 2009 Jul;8(14):1389-401
Signaling by hypoxia-inducible factors is critical for ovulation in mice.
Kim J, Bagchi IC, Bagchi MK
Endocrinology 2009 Jul;150(7):3392-400
Endocrinology 2009 Jul;150(7):3392-400
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia.
Fang HY, Hughes R, Murdoch C, Coffelt SB, Biswas SK, Harris AL, Johnson RS, Imityaz HZ, Simon MC, Fredlund E, Greten FR, Rius J, Lewis CE
Blood 2009 Jul 23;114(4):844-59
Blood 2009 Jul 23;114(4):844-59
Hypoxia decreases insulin signaling pathways in adipocytes.
Regazzetti C, Peraldi P, Grémeaux T, Najem-Lendom R, Ben-Sahra I, Cormont M, Bost F, Le Marchand-Brustel Y, Tanti JF, Giorgetti-Peraldi S
Diabetes 2009 Jan;58(1):95-103
Diabetes 2009 Jan;58(1):95-103
Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells.
Lee K, Qian DZ, Rey S, Wei H, Liu JO, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2009 Feb 17;106(7):2353-8
Proceedings of the National Academy of Sciences of the United States of America 2009 Feb 17;106(7):2353-8
Human cancers converge at the HIF-2alpha oncogenic axis.
Franovic A, Holterman CE, Payette J, Lee S
Proceedings of the National Academy of Sciences of the United States of America 2009 Dec 15;106(50):21306-11
Proceedings of the National Academy of Sciences of the United States of America 2009 Dec 15;106(50):21306-11
Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia.
Rey S, Lee K, Wang CJ, Gupta K, Chen S, McMillan A, Bhise N, Levchenko A, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2009 Dec 1;106(48):20399-404
Proceedings of the National Academy of Sciences of the United States of America 2009 Dec 1;106(48):20399-404
Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic hepatocytes.
Copple BL, Bustamante JJ, Welch TP, Kim ND, Moon JO
Liver international : official journal of the International Association for the Study of the Liver 2009 Aug;29(7):1010-21
Liver international : official journal of the International Association for the Study of the Liver 2009 Aug;29(7):1010-21
Iron transporters are differentially regulated by dietary iron, and modifications are associated with changes in manganese metabolism in young pigs.
Hansen SL, Trakooljul N, Liu HC, Moeser AJ, Spears JW
The Journal of nutrition 2009 Aug;139(8):1474-9
The Journal of nutrition 2009 Aug;139(8):1474-9
Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor.
Wacker I, Sachs M, Knaup K, Wiesener M, Weiske J, Huber O, Akçetin Z, Behrens J
Molecular and cellular biology 2009 Apr;29(7):1707-18
Molecular and cellular biology 2009 Apr;29(7):1707-18
Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis.
Woo JK, Choi DS, Tran HT, Gilbert BE, Hong WK, Lee HY
Cancer prevention research (Philadelphia, Pa.) 2009 Apr;2(4):361-9
Cancer prevention research (Philadelphia, Pa.) 2009 Apr;2(4):361-9
VHL Type 2B gene mutation moderates HIF dosage in vitro and in vivo.
Lee CM, Hickey MM, Sanford CA, McGuire CG, Cowey CL, Simon MC, Rathmell WK
Oncogene 2009 Apr 9;28(14):1694-705
Oncogene 2009 Apr 9;28(14):1694-705
Myocardial hypertrophy overrides the angiogenic response to hypoxia.
Choi YH, Cowan DB, Nathan M, Poutias D, Stamm C, del Nido PJ, McGowan FX Jr
PloS one 2008;3(12):e4042
PloS one 2008;3(12):e4042
A Key role for cyclic AMP-responsive element binding protein in hypoxia-mediated activation of the angiogenesis factor CCN1 (CYR61) in Tumor cells.
Meyuhas R, Pikarsky E, Tavor E, Klar A, Abramovitch R, Hochman J, Lago TG, Honigman A
Molecular cancer research : MCR 2008 Sep;6(9):1397-409
Molecular cancer research : MCR 2008 Sep;6(9):1397-409
Hypoxia-inducible factor-2alpha regulates the expression of TRAIL receptor DR5 in renal cancer cells.
Mahajan S, Dammai V, Hsu T, Kraft AS
Carcinogenesis 2008 Sep;29(9):1734-41
Carcinogenesis 2008 Sep;29(9):1734-41
Activation of the VEGFR1 chromatin domain: an angiogenic signal-ETS1/HIF-2alpha regulatory axis.
Dutta D, Ray S, Vivian JL, Paul S
The Journal of biological chemistry 2008 Sep 12;283(37):25404-13
The Journal of biological chemistry 2008 Sep 12;283(37):25404-13
Constitutive expression of HIF-1alpha and HIF-2alpha in bone marrow stromal cells differentially promotes their proangiogenic properties.
Ben-Shoshan J, Schwartz S, Luboshits G, Maysel-Auslender S, Barzelay A, Polak-Charcon S, Tzahor E, Barshack I, Barak A, Levkovitch-Verbin H, Keren G, George J
Stem cells (Dayton, Ohio) 2008 Oct;26(10):2634-43
Stem cells (Dayton, Ohio) 2008 Oct;26(10):2634-43
Induction of pyruvate dehydrogenase kinase-3 by hypoxia-inducible factor-1 promotes metabolic switch and drug resistance.
Lu CW, Lin SC, Chen KF, Lai YY, Tsai SJ
The Journal of biological chemistry 2008 Oct 17;283(42):28106-14
The Journal of biological chemistry 2008 Oct 17;283(42):28106-14
The biphasic role of the hypoxia-inducible factor prolyl-4-hydroxylase, PHD2, in modulating tumor-forming potential.
Lee K A, Lynd JD, O'Reilly S, Kiupel M, McCormick JJ, LaPres JJ
Molecular cancer research : MCR 2008 May;6(5):829-42
Molecular cancer research : MCR 2008 May;6(5):829-42
Oxygenated perfluorochemicals improve cell survival during reoxygenation by pacifying mitochondrial activity.
Arab A, Kuemmerer K, Wang J, Bode C, Hehrlein C
The Journal of pharmacology and experimental therapeutics 2008 May;325(2):417-24
The Journal of pharmacology and experimental therapeutics 2008 May;325(2):417-24
Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein.
Zhou G, Dada LA, Chandel NS, Iwai K, Lecuona E, Ciechanover A, Sznajder JI
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008 May;22(5):1335-42
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008 May;22(5):1335-42
HIV-1 upregulates VEGF in podocytes.
Korgaonkar SN, Feng X, Ross MD, Lu TC, D'Agati V, Iyengar R, Klotman PE, He JC
Journal of the American Society of Nephrology : JASN 2008 May;19(5):877-83
Journal of the American Society of Nephrology : JASN 2008 May;19(5):877-83
Enhancement of Angiogenesis Through Stabilization of Hypoxia-inducible Factor-1 by Silencing Prolyl Hydroxylase Domain-2 Gene
Shourong Wu, Nobuhiro Nishiyama, Mitsunobu R Kano, Yasuyuki Morishita, Kohei Miyazono, Keiji Itaka, Ung-il Chung, Kazunori Kataoka
Molecular Therapy 2008 May;16(7):1227-1234
Molecular Therapy 2008 May;16(7):1227-1234
Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family.
Evens AM, Schumacker PT, Helenowski IB, Singh AT, Dokic D, Keswani A, Kordeluk E, Raji A, Winter JN, Jovanovic BD, Holmgren A, Nelson BP, Gordon LI
British journal of haematology 2008 May;141(5):676-80
British journal of haematology 2008 May;141(5):676-80
Proteasomal activity in placentas from women with preeclampsia and intrauterine growth restriction: implications for expression of HIF-alpha proteins.
Rajakumar A, Michael HM, Daftary A, Jeyabalan A, Gilmour C, Conrad KP
Placenta 2008 Mar;29(3):290-9
Placenta 2008 Mar;29(3):290-9
PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis.
Ginouvès A, Ilc K, Macías N, Pouysségur J, Berra E
Proceedings of the National Academy of Sciences of the United States of America 2008 Mar 25;105(12):4745-50
Proceedings of the National Academy of Sciences of the United States of America 2008 Mar 25;105(12):4745-50
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure.
Minamishima YA, Moslehi J, Bardeesy N, Cullen D, Bronson RT, Kaelin WG Jr
Blood 2008 Mar 15;111(6):3236-44
Blood 2008 Mar 15;111(6):3236-44
Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins.
Takeda K, Aguila HL, Parikh NS, Li X, Lamothe K, Duan LJ, Takeda H, Lee FS, Fong GH
Blood 2008 Mar 15;111(6):3229-35
Blood 2008 Mar 15;111(6):3229-35
Induction of HIF-2alpha is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line.
Brown ST, Nurse CA
American journal of physiology. Cell physiology 2008 Jun;294(6):C1305-12
American journal of physiology. Cell physiology 2008 Jun;294(6):C1305-12
Regulation of hypoxia-inducible factor-1alpha by NF-kappaB.
van Uden P, Kenneth NS, Rocha S
The Biochemical journal 2008 Jun 15;412(3):477-84
The Biochemical journal 2008 Jun 15;412(3):477-84
Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha.
Puppo M, Battaglia F, Ottaviano C, Delfino S, Ribatti D, Varesio L, Bosco MC
Molecular cancer therapeutics 2008 Jul;7(7):1974-84
Molecular cancer therapeutics 2008 Jul;7(7):1974-84
Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene.
Wu S, Nishiyama N, Kano MR, Morishita Y, Miyazono K, Itaka K, Chung UI, Kataoka K
Molecular therapy : the journal of the American Society of Gene Therapy 2008 Jul;16(7):1227-34
Molecular therapy : the journal of the American Society of Gene Therapy 2008 Jul;16(7):1227-34
Placental HIFs as markers of cerebral hypoxic distress in fetal mice.
Trollmann R, Strasser K, Keller S, Antoniou X, Grenacher B, Ogunshola OO, Dötsch J, Rascher W, Gassmann M
American journal of physiology. Regulatory, integrative and comparative physiology 2008 Dec;295(6):R1973-81
American journal of physiology. Regulatory, integrative and comparative physiology 2008 Dec;295(6):R1973-81
Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation.
Koh MY, Darnay BG, Powis G
Molecular and cellular biology 2008 Dec;28(23):7081-95
Molecular and cellular biology 2008 Dec;28(23):7081-95
Small-molecule inhibitors of HIF-2a translation link its 5'UTR iron-responsive element to oxygen sensing.
Zimmer M, Ebert BL, Neil C, Brenner K, Papaioannou I, Melas A, Tolliday N, Lamb J, Pantopoulos K, Golub T, Iliopoulos O
Molecular cell 2008 Dec 26;32(6):838-48
Molecular cell 2008 Dec 26;32(6):838-48
Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy.
Sears JE, Hoppe G, Ebrahem Q, Anand-Apte B
Proceedings of the National Academy of Sciences of the United States of America 2008 Dec 16;105(50):19898-903
Proceedings of the National Academy of Sciences of the United States of America 2008 Dec 16;105(50):19898-903
Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth.
Zhang H, Qian DZ, Tan YS, Lee K, Gao P, Ren YR, Rey S, Hammers H, Chang D, Pili R, Dang CV, Liu JO, Semenza GL
Proceedings of the National Academy of Sciences of the United States of America 2008 Dec 16;105(50):19579-86
Proceedings of the National Academy of Sciences of the United States of America 2008 Dec 16;105(50):19579-86
The microenvironment for erythropoiesis is regulated by HIF-2alpha through VCAM-1 in endothelial cells.
Yamashita T, Ohneda O, Sakiyama A, Iwata F, Ohneda K, Fujii-Kuriyama Y
Blood 2008 Aug 15;112(4):1482-92
Blood 2008 Aug 15;112(4):1482-92
HIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle.
Milkiewicz M, Doyle JL, Fudalewski T, Ispanovic E, Aghasi M, Haas TL
The Journal of physiology 2007 Sep 1;583(Pt 2):753-66
The Journal of physiology 2007 Sep 1;583(Pt 2):753-66
Involvement of chloride channels in TGF-beta1-induced apoptosis of human bronchial epithelial cells.
Cheng G, Shao Z, Chaudhari B, Agrawal DK
American journal of physiology. Lung cellular and molecular physiology 2007 Nov;293(5):L1339-47
American journal of physiology. Lung cellular and molecular physiology 2007 Nov;293(5):L1339-47
The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha.
Hu CJ, Sataur A, Wang L, Chen H, Simon MC
Molecular biology of the cell 2007 Nov;18(11):4528-42
Molecular biology of the cell 2007 Nov;18(11):4528-42
Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells.
MacKenzie ED, Selak MA, Tennant DA, Payne LJ, Crosby S, Frederiksen CM, Watson DG, Gottlieb E
Molecular and cellular biology 2007 May;27(9):3282-9
Molecular and cellular biology 2007 May;27(9):3282-9
Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency.
Sanchez M, Galy B, Muckenthaler MU, Hentze MW
Nature structural & molecular biology 2007 May;14(5):420-6
Nature structural & molecular biology 2007 May;14(5):420-6
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity.
Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, Dang CV, Semenza GL
Cancer cell 2007 May;11(5):407-20
Cancer cell 2007 May;11(5):407-20
Renal cancer cells lacking hypoxia inducible factor (HIF)-1alpha expression maintain vascular endothelial growth factor expression through HIF-2alpha.
Shinojima T, Oya M, Takayanagi A, Mizuno R, Shimizu N, Murai M
Carcinogenesis 2007 Mar;28(3):529-36
Carcinogenesis 2007 Mar;28(3):529-36
NAD(P)H oxidases regulate HIF-2alpha protein expression.
Block K, Gorin Y, Hoover P, Williams P, Chelmicki T, Clark RA, Yoneda T, Abboud HE
The Journal of biological chemistry 2007 Mar 16;282(11):8019-26
The Journal of biological chemistry 2007 Mar 16;282(11):8019-26
Hypoxia-inducible factors HIF-1alpha and HIF-2alpha are decreased in an experimental model of severe respiratory distress syndrome in preterm lambs.
Grover TR, Asikainen TM, Kinsella JP, Abman SH, White CW
American journal of physiology. Lung cellular and molecular physiology 2007 Jun;292(6):L1345-51
American journal of physiology. Lung cellular and molecular physiology 2007 Jun;292(6):L1345-51
The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.
Wang Y, Wan C, Deng L, Liu X, Cao X, Gilbert SR, Bouxsein ML, Faugere MC, Guldberg RE, Gerstenfeld LC, Haase VH, Johnson RS, Schipani E, Clemens TL
The Journal of clinical investigation 2007 Jun;117(6):1616-26
The Journal of clinical investigation 2007 Jun;117(6):1616-26
HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation.
Hughes MD, Kapllani E, Alexander AE, Burk RD, Schoenfeld AR
Cancer cell international 2007 Jun 28;7:13
Cancer cell international 2007 Jun 28;7:13
Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood.
Nagano M, Yamashita T, Hamada H, Ohneda K, Kimura K, Nakagawa T, Shibuya M, Yoshikawa H, Ohneda O
Blood 2007 Jul 1;110(1):151-60
Blood 2007 Jul 1;110(1):151-60
VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail.
Evans AJ, Russell RC, Roche O, Burry TN, Fish JE, Chow VW, Kim WY, Saravanan A, Maynard MA, Gervais ML, Sufan RI, Roberts AM, Wilson LA, Betten M, Vandewalle C, Berx G, Marsden PA, Irwin MS, Teh BT, Jewett MA, Ohh M
Molecular and cellular biology 2007 Jan;27(1):157-69
Molecular and cellular biology 2007 Jan;27(1):157-69
Prolyl-hydroxylase inhibition and HIF activation in osteoblasts promotes an adipocytic phenotype.
Irwin R, LaPres JJ, Kinser S, McCabe LR
Journal of cellular biochemistry 2007 Feb 15;100(3):762-72
Journal of cellular biochemistry 2007 Feb 15;100(3):762-72
Acute postnatal ablation of Hif-2alpha results in anemia.
Gruber M, Hu CJ, Johnson RS, Brown EJ, Keith B, Simon MC
Proceedings of the National Academy of Sciences of the United States of America 2007 Feb 13;104(7):2301-6
Proceedings of the National Academy of Sciences of the United States of America 2007 Feb 13;104(7):2301-6
von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis.
Hickey MM, Lam JC, Bezman NA, Rathmell WK, Simon MC
The Journal of clinical investigation 2007 Dec;117(12):3879-89
The Journal of clinical investigation 2007 Dec;117(12):3879-89
Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation.
Lomb DJ, Straub JA, Freeman RS
Journal of neurochemistry 2007 Dec;103(5):1897-906
Journal of neurochemistry 2007 Dec;103(5):1897-906
Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.
Li L, Zhang L, Zhang X, Yan Q, Minamishima YA, Olumi AF, Mao M, Bartz S, Kaelin WG Jr
Molecular and cellular biology 2007 Aug;27(15):5381-92
Molecular and cellular biology 2007 Aug;27(15):5381-92
Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.
Takeda K, Cowan A, Fong GH
Circulation 2007 Aug 14;116(7):774-81
Circulation 2007 Aug 14;116(7):774-81
Localization of immunoreactive HIF-1alpha and HIF-2alpha in neuroendocrine cells of both benign and malignant prostate glands.
Monsef N, Helczynski L, Lundwall A, Påhlman S, Anders-Bjartell.
The Prostate 2007 Aug 1;67(11):1219-29
The Prostate 2007 Aug 1;67(11):1219-29
Hypoxia-inducible factors in the first trimester human lung.
Groenman F, Rutter M, Caniggia I, Tibboel D, Post M
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007 Apr;55(4):355-63
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007 Apr;55(4):355-63
Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney.
Kojima I, Tanaka T, Inagi R, Kato H, Yamashita T, Sakiyama A, Ohneda O, Takeda N, Sata M, Miyata T, Fujita T, Nangaku M
Journal of the American Society of Nephrology : JASN 2007 Apr;18(4):1218-26
Journal of the American Society of Nephrology : JASN 2007 Apr;18(4):1218-26
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo.
Rankin EB, Biju MP, Liu Q, Unger TL, Rha J, Johnson RS, Simon MC, Keith B, Haase VH
The Journal of clinical investigation 2007 Apr;117(4):1068-77
The Journal of clinical investigation 2007 Apr;117(4):1068-77
The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes.
Chavez JC, Baranova O, Lin J, Pichiule P
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Sep 13;26(37):9471-81
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 Sep 13;26(37):9471-81
Regulation of the chemokine receptor CXCR4 and metastasis by hypoxia-inducible factor in non small cell lung cancer cell lines.
Liu YL, Yu JM, Song XR, Wang XW, Xing LG, Gao BB
Cancer biology & therapy 2006 Oct;5(10):1320-6
Cancer biology & therapy 2006 Oct;5(10):1320-6
Regulation of the chemokine receptor CXCR4 and metastasis by hypoxia-inducible factor in non small cell lung cancer cell lines.
Liu YL, Yu JM, Song XR, Wang XW, Xing LG, Gao BB
Cancer biology & therapy 2006 Oct;5(10):1320-6
Cancer biology & therapy 2006 Oct;5(10):1320-6
Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo.
Kim WY, Safran M, Buckley MR, Ebert BL, Glickman J, Bosenberg M, Regan M, Kaelin WG Jr
The EMBO journal 2006 Oct 4;25(19):4650-62
The EMBO journal 2006 Oct 4;25(19):4650-62
Differentiation arrest by hypoxia.
Lin Q, Lee YJ, Yun Z
The Journal of biological chemistry 2006 Oct 13;281(41):30678-83
The Journal of biological chemistry 2006 Oct 13;281(41):30678-83
Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII.
Koizume S, Jin MS, Miyagi E, Hirahara F, Nakamura Y, Piao JH, Asai A, Yoshida A, Tsuchiya E, Ruf W, Miyagi Y
Cancer research 2006 Oct 1;66(19):9453-60
Cancer research 2006 Oct 1;66(19):9453-60
Latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells activates hypoxia-induced factors.
Carroll PA, Kenerson HL, Yeung RS, Lagunoff M
Journal of virology 2006 Nov;80(21):10802-12
Journal of virology 2006 Nov;80(21):10802-12
Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2.
Takeda K, Ho VC, Takeda H, Duan LJ, Nagy A, Fong GH
Molecular and cellular biology 2006 Nov;26(22):8336-46
Molecular and cellular biology 2006 Nov;26(22):8336-46
Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells.
Hu CJ, Iyer S, Sataur A, Covello KL, Chodosh LA, Simon MC
Molecular and cellular biology 2006 May;26(9):3514-26
Molecular and cellular biology 2006 May;26(9):3514-26
Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc.
Mizukami Y, Fujiki K, Duerr EM, Gala M, Jo WS, Zhang X, Chung DC
The Journal of biological chemistry 2006 May 19;281(20):13957-63
The Journal of biological chemistry 2006 May 19;281(20):13957-63
Calcium signaling stimulates translation of HIF-alpha during hypoxia.
Hui AS, Bauer AL, Striet JB, Schnell PO, Czyzyk-Krzeska MF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Mar;20(3):466-75
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Mar;20(3):466-75
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.
Krishnamachary B, Zagzag D, Nagasawa H, Rainey K, Okuyama H, Baek JH, Semenza GL
Cancer research 2006 Mar 1;66(5):2725-31
Cancer research 2006 Mar 1;66(5):2725-31
Hypoxia and hypoxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells.
Schultz K, Fanburg BL, Beasley D
American journal of physiology. Heart and circulatory physiology 2006 Jun;290(6):H2528-34
American journal of physiology. Heart and circulatory physiology 2006 Jun;290(6):H2528-34
Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1.
Okuyama H, Krishnamachary B, Zhou YF, Nagasawa H, Bosch-Marce M, Semenza GL
The Journal of biological chemistry 2006 Jun 2;281(22):15554-63
The Journal of biological chemistry 2006 Jun 2;281(22):15554-63
Dynamic HIF1A regulation during human placental development.
Ietta F, Wu Y, Winter J, Xu J, Wang J, Post M, Caniggia I
Biology of reproduction 2006 Jul;75(1):112-21
Biology of reproduction 2006 Jul;75(1):112-21
Primary cilium formation requires von hippel-lindau gene function in renal-derived cells.
Lutz MS, Burk RD
Cancer research 2006 Jul 15;66(14):6903-7
Cancer research 2006 Jul 15;66(14):6903-7
Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis.
Kurban G, Hudon V, Duplan E, Ohh M, Pause A
Cancer research 2006 Feb 1;66(3):1313-9
Cancer research 2006 Feb 1;66(3):1313-9
Priming-dependent phosphorylation and regulation of the tumor suppressor pVHL by glycogen synthase kinase 3.
Hergovich A, Lisztwan J, Thoma CR, Wirbelauer C, Barry RE, Krek W
Molecular and cellular biology 2006 Aug;26(15):5784-96
Molecular and cellular biology 2006 Aug;26(15):5784-96
Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17.
Franovic A, Robert I, Smith K, Kurban G, Pause A, Gunaratnam L, Lee S
Cancer research 2006 Aug 15;66(16):8083-90
Cancer research 2006 Aug 15;66(16):8083-90
Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment.
Bracken CP, Fedele AO, Linke S, Balrak W, Lisy K, Whitelaw ML, Peet DJ
The Journal of biological chemistry 2006 Aug 11;281(32):22575-85
The Journal of biological chemistry 2006 Aug 11;281(32):22575-85
Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells.
Nakamura K, Martin KC, Jackson JK, Beppu K, Woo CW, Thiele CJ
Cancer research 2006 Apr 15;66(8):4249-55
Cancer research 2006 Apr 15;66(8):4249-55
Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells.
Calvani M, Rapisarda A, Uranchimeg B, Shoemaker RH, Melillo G
Blood 2006 Apr 1;107(7):2705-12
Blood 2006 Apr 1;107(7):2705-12
Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL.hypoxia-inducible transcription factor-1alpha complex.
Miller F, Kentsis A, Osman R, Pan ZQ
The Journal of biological chemistry 2005 Mar 4;280(9):7985-96
The Journal of biological chemistry 2005 Mar 4;280(9):7985-96
Activation of HIF-prolyl hydroxylases by R59949, an inhibitor of the diacylglycerol kinase.
Temes E, Martín-Puig S, Acosta-Iborra B, Castellanos MC, Feijoo-Cuaresma M, Olmos G, Aragonés J, Landazuri MO
The Journal of biological chemistry 2005 Jun 24;280(25):24238-44
The Journal of biological chemistry 2005 Jun 24;280(25):24238-44
Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer.
Smith K, Gunaratnam L, Morley M, Franovic A, Mekhail K, Lee S
Cancer research 2005 Jun 15;65(12):5221-30
Cancer research 2005 Jun 15;65(12):5221-30
Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung.
Asikainen TM, Schneider BK, Waleh NS, Clyman RI, Ho WB, Flippin LA, Günzler V, White CW
Proceedings of the National Academy of Sciences of the United States of America 2005 Jul 19;102(29):10212-7
Proceedings of the National Academy of Sciences of the United States of America 2005 Jul 19;102(29):10212-7
Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor.
Zagzag D, Krishnamachary B, Yee H, Okuyama H, Chiriboga L, Ali MA, Melamed J, Semenza GL
Cancer research 2005 Jul 15;65(14):6178-88
Cancer research 2005 Jul 15;65(14):6178-88
Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma.
Petrella BL, Lohi J, Brinckerhoff CE
Oncogene 2005 Feb 3;24(6):1043-52
Oncogene 2005 Feb 3;24(6):1043-52
Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.
Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG Jr, Schlisio S
Cancer cell 2005 Aug;8(2):155-67
Cancer cell 2005 Aug;8(2):155-67
Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta.
Maltepe E, Krampitz GW, Okazaki KM, Red-Horse K, Mak W, Simon MC, Fisher SJ
Development (Cambridge, England) 2005 Aug;132(15):3393-403
Development (Cambridge, England) 2005 Aug;132(15):3393-403
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes.
Biju MP, Neumann AK, Bensinger SJ, Johnson RS, Turka LA, Haase VH
Molecular and cellular biology 2004 Oct;24(20):9038-47
Molecular and cellular biology 2004 Oct;24(20):9038-47
Divergent expression patterns for hypoxia-inducible factor-1beta and aryl hydrocarbon receptor nuclear transporter-2 in developing kidney.
Freeburg PB, Abrahamson DR
Journal of the American Society of Nephrology : JASN 2004 Oct;15(10):2569-78
Journal of the American Society of Nephrology : JASN 2004 Oct;15(10):2569-78
Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.
Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, Ferrara N, Johnson RS
Cancer cell 2004 Nov;6(5):485-95
Cancer cell 2004 Nov;6(5):485-95
Evidence for the functional activity of hypoxia-inducible transcription factors overexpressed in preeclamptic placentae.
Rajakumar A, Brandon HM, Daftary A, Ness R, Conrad KP
Placenta 2004 Nov;25(10):763-9
Placenta 2004 Nov;25(10):763-9
Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha.
Welsh S, Williams R, Kirkpatrick L, Paine-Murrieta G, Powis G
Molecular cancer therapeutics 2004 Mar;3(3):233-44
Molecular cancer therapeutics 2004 Mar;3(3):233-44
Role of iron (II)-2-oxoglutarate-dependent dioxygenases in the generation of hypoxia-induced phosphatidic acid through HIF-1/2 and von Hippel-Lindau-independent mechanisms.
Martín-Puig S, Temes E, Olmos G, Jones DR, Aragonés J, Landázuri MO
The Journal of biological chemistry 2004 Mar 5;279(10):9504-11
The Journal of biological chemistry 2004 Mar 5;279(10):9504-11
Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer.
Mizukami Y, Li J, Zhang X, Zimmer MA, Iliopoulos O, Chung DC
Cancer research 2004 Mar 1;64(5):1765-72
Cancer research 2004 Mar 1;64(5):1765-72
Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer.
Mizukami Y, Li J, Zhang X, Zimmer MA, Iliopoulos O, Chung DC
Cancer research 2004 Mar 1;64(5):1765-72
Cancer research 2004 Mar 1;64(5):1765-72
p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment.
Pan Y, Oprysko PR, Asham AM, Koch CJ, Simon MC
Oncogene 2004 Jun 24;23(29):4975-83
Oncogene 2004 Jun 24;23(29):4975-83
HIF activation by pH-dependent nucleolar sequestration of VHL.
Mekhail K, Gunaratnam L, Bonicalzi ME, Lee S
Nature cell biology 2004 Jul;6(7):642-7
Nature cell biology 2004 Jul;6(7):642-7
Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1.
Takeda N, Maemura K, Imai Y, Harada T, Kawanami D, Nojiri T, Manabe I, Nagai R
Circulation research 2004 Jul 23;95(2):146-53
Circulation research 2004 Jul 23;95(2):146-53
Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma.
Grabmaier K, A de Weijert MC, Verhaegh GW, Schalken JA, Oosterwijk E
Oncogene 2004 Jul 22;23(33):5624-31
Oncogene 2004 Jul 22;23(33):5624-31
Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.
Zimmer M, Doucette D, Siddiqui N, Iliopoulos O
Molecular cancer research : MCR 2004 Feb;2(2):89-95
Molecular cancer research : MCR 2004 Feb;2(2):89-95
In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations.
Rathmell WK, Hickey MM, Bezman NA, Chmielecki CA, Carraway NC, Simon MC
Cancer research 2004 Dec 1;64(23):8595-603
Cancer research 2004 Dec 1;64(23):8595-603
The PAI-1 gene as a direct target of endothelial PAS domain protein-1 in adenocarcinoma A549 cells.
Sato M, Tanaka T, Maemura K, Uchiyama T, Sato H, Maeno T, Suga T, Iso T, Ohyama Y, Arai M, Tamura J, Sakamoto H, Nagai R, Kurabayashi M
American journal of respiratory cell and molecular biology 2004 Aug;31(2):209-15
American journal of respiratory cell and molecular biology 2004 Aug;31(2):209-15
Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha.
Uchida T, Rossignol F, Matthay MA, Mounier R, Couette S, Clottes E, Clerici C
The Journal of biological chemistry 2004 Apr 9;279(15):14871-8
The Journal of biological chemistry 2004 Apr 9;279(15):14871-8
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.
Staller P, Sulitkova J, Lisztwan J, Moch H, Oakeley EJ, Krek W
Nature 2003 Sep 18;425(6955):307-11
Nature 2003 Sep 18;425(6955):307-11
Specific oncolytic effect of a new hypoxia-inducible factor-dependent replicative adenovirus on von Hippel-Lindau-defective renal cell carcinomas.
Cuevas Y, Hernández-Alcoceba R, Aragones J, Naranjo-Suárez S, Castellanos MC, Esteban MA, Martín-Puig S, Landazuri MO, del Peso L
Cancer research 2003 Oct 15;63(20):6877-84
Cancer research 2003 Oct 15;63(20):6877-84
Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein.
Corn PG, McDonald ER 3rd, Herman JG, El-Deiry WS
Nature genetics 2003 Nov;35(3):229-37
Nature genetics 2003 Nov;35(3):229-37
Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor.
Baba M, Hirai S, Yamada-Okabe H, Hamada K, Tabuchi H, Kobayashi K, Kondo K, Yoshida M, Yamashita A, Kishida T, Nakaigawa N, Nagashima Y, Kubota Y, Yao M, Ohno S
Oncogene 2003 May 8;22(18):2728-38
Oncogene 2003 May 8;22(18):2728-38
Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha.
Yuan Y, Hilliard G, Ferguson T, Millhorn DE
The Journal of biological chemistry 2003 May 2;278(18):15911-6
The Journal of biological chemistry 2003 May 2;278(18):15911-6
Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene.
Liu MY, Poellinger L, Walker CL
Cancer research 2003 May 15;63(10):2675-80
Cancer research 2003 May 15;63(10):2675-80
Induction of T-type calcium channel gene expression by chronic hypoxia.
Del Toro R, Levitsky KL, López-Barneo J, Chiara MD
The Journal of biological chemistry 2003 Jun 20;278(25):22316-24
The Journal of biological chemistry 2003 Jun 20;278(25):22316-24
Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3'-kinase/protein kinase B in prostate cancer cells.
Mabjeesh NJ, Willard MT, Frederickson CE, Zhong H, Simons JW
Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Jul;9(7):2416-25
Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Jul;9(7):2416-25
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha.
Park SK, Dadak AM, Haase VH, Fontana L, Giaccia AJ, Johnson RS
Molecular and cellular biology 2003 Jul;23(14):4959-71
Molecular and cellular biology 2003 Jul;23(14):4959-71
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha.
Park SK, Dadak AM, Haase VH, Fontana L, Giaccia AJ, Johnson RS
Molecular and cellular biology 2003 Jul;23(14):4959-71
Molecular and cellular biology 2003 Jul;23(14):4959-71
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth.
Mack FA, Rathmell WK, Arsham AM, Gnarra J, Keith B, Simon MC
Cancer cell 2003 Jan;3(1):75-88
Cancer cell 2003 Jan;3(1):75-88
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth.
Mack FA, Rathmell WK, Arsham AM, Gnarra J, Keith B, Simon MC
Cancer cell 2003 Jan;3(1):75-88
Cancer cell 2003 Jan;3(1):75-88
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.
Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC
Molecular and cellular biology 2003 Dec;23(24):9361-74
Molecular and cellular biology 2003 Dec;23(24):9361-74
Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.
Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC
Molecular and cellular biology 2003 Dec;23(24):9361-74
Molecular and cellular biology 2003 Dec;23(24):9361-74
Peritubular capillary loss after mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia-inducible factor-1 alpha.
Yuan HT, Li XZ, Pitera JE, Long DA, Woolf AS
The American journal of pathology 2003 Dec;163(6):2289-301
The American journal of pathology 2003 Dec;163(6):2289-301
Peritubular capillary loss after mouse acute nephrotoxicity correlates with down-regulation of vascular endothelial growth factor-A and hypoxia-inducible factor-1 alpha.
Yuan HT, Li XZ, Pitera JE, Long DA, Woolf AS
The American journal of pathology 2003 Dec;163(6):2289-301
The American journal of pathology 2003 Dec;163(6):2289-301
The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen.
del Peso L, Castellanos MC, Temes E, Martin-Puig S, Cuevas Y, Olmos G, Landazuri MO
The Journal of biological chemistry 2003 Dec 5;278(49):48690-5
The Journal of biological chemistry 2003 Dec 5;278(49):48690-5
Down-regulation of hypoxia-inducible factor-2 in PC12 cells by nerve growth factor stimulation.
Naranjo-Suárez S, Castellanos MC, Alvarez-Tejado M, Vara A, Landázuri MO, del Peso L
The Journal of biological chemistry 2003 Aug 22;278(34):31895-901
The Journal of biological chemistry 2003 Aug 22;278(34):31895-901
von Hippel-Lindau protein complex is regulated by cell density.
Mohan S, Burk RD
Oncogene 2003 Aug 14;22(34):5270-80
Oncogene 2003 Aug 14;22(34):5270-80
Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells.
Palayoor ST, Tofilon PJ, Coleman CN
Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Aug 1;9(8):3150-7
Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Aug 1;9(8):3150-7
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.
Mabjeesh NJ, Escuin D, LaVallee TM, Pribluda VS, Swartz GM, Johnson MS, Willard MT, Zhong H, Simons JW, Giannakakou P
Cancer cell 2003 Apr;3(4):363-75
Cancer cell 2003 Apr;3(4):363-75
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.
Mabjeesh NJ, Escuin D, LaVallee TM, Pribluda VS, Swartz GM, Johnson MS, Willard MT, Zhong H, Simons JW, Giannakakou P
Cancer cell 2003 Apr;3(4):363-75
Cancer cell 2003 Apr;3(4):363-75
Overexpression of the EGFR/FKBP12/HIF-2alpha pathway identified in childhood astrocytomas by angiogenesis gene profiling.
Khatua S, Peterson KM, Brown KM, Lawlor C, Santi MR, LaFleur B, Dressman D, Stephan DA, MacDonald TJ
Cancer research 2003 Apr 15;63(8):1865-70
Cancer research 2003 Apr 15;63(8):1865-70
HIF-2alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells.
Graven KK, Bellur D, Klahn BD, Lowrey SL, Amberger E
Biochimica et biophysica acta 2003 Apr 15;1626(1-3):10-8
Biochimica et biophysica acta 2003 Apr 15;1626(1-3):10-8
HIF-2alpha regulates glyceraldehyde-3-phosphate dehydrogenase expression in endothelial cells.
Graven KK, Bellur D, Klahn BD, Lowrey SL, Amberger E
Biochimica et biophysica acta 2003 Apr 15;1626(1-3):10-8
Biochimica et biophysica acta 2003 Apr 15;1626(1-3):10-8
Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha.
Chan DA, Sutphin PD, Denko NC, Giaccia AJ
The Journal of biological chemistry 2002 Oct 18;277(42):40112-7
The Journal of biological chemistry 2002 Oct 18;277(42):40112-7
Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance.
Bernaudin M, Tang Y, Reilly M, Petit E, Sharp FR
The Journal of biological chemistry 2002 Oct 18;277(42):39728-38
The Journal of biological chemistry 2002 Oct 18;277(42):39728-38
Positive expression of HIF-2alpha/EPAS1 in invasive bladder cancer.
Xia G, Kageyama Y, Hayashi T, Hyochi N, Kawakami S, Kihara K
Urology 2002 May;59(5):774-8
Urology 2002 May;59(5):774-8
Positive expression of HIF-2alpha/EPAS1 in invasive bladder cancer.
Xia G, Kageyama Y, Hayashi T, Hyochi N, Kawakami S, Kihara K
Urology 2002 May;59(5):774-8
Urology 2002 May;59(5):774-8
Activation of vascular endothelial growth factor A transcription in tumorigenic glioblastoma cell lines by an enhancer with cell type-specific DNase I accessibility.
Liang Y, Li XY, Rebar EJ, Li P, Zhou Y, Chen B, Wolffe AP, Case CC
The Journal of biological chemistry 2002 May 31;277(22):20087-94
The Journal of biological chemistry 2002 May 31;277(22):20087-94
Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy.
Burke B, Tang N, Corke KP, Tazzyman D, Ameri K, Wells M, Lewis CE
The Journal of pathology 2002 Feb;196(2):204-12
The Journal of pathology 2002 Feb;196(2):204-12
Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect.
Minchenko A, Leshchinsky I, Opentanova I, Sang N, Srinivas V, Armstead V, Caro J
The Journal of biological chemistry 2002 Feb 22;277(8):6183-7
The Journal of biological chemistry 2002 Feb 22;277(8):6183-7
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma.
Maranchie JK, Vasselli JR, Riss J, Bonifacino JS, Linehan WM, Klausner RD
Cancer cell 2002 Apr;1(3):247-55
Cancer cell 2002 Apr;1(3):247-55
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma.
Maranchie JK, Vasselli JR, Riss J, Bonifacino JS, Linehan WM, Klausner RD
Cancer cell 2002 Apr;1(3):247-55
Cancer cell 2002 Apr;1(3):247-55
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG Jr
Cancer cell 2002 Apr;1(3):237-46
Cancer cell 2002 Apr;1(3):237-46
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein.
Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG Jr
Cancer cell 2002 Apr;1(3):237-46
Cancer cell 2002 Apr;1(3):237-46
Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension.
Alvarez-Tejado M, Alfranca A, Aragonés J, Vara A, Landázuri MO, del Peso L
The Journal of biological chemistry 2002 Apr 19;277(16):13508-17
The Journal of biological chemistry 2002 Apr 19;277(16):13508-17
Histologic atrial myolysis is associated with atrial fibrillation after cardiac operation.
Ad N, Snir E, Vidne BA, Golomb E
The Annals of thoracic surgery 2001 Sep;72(3):688-93
The Annals of thoracic surgery 2001 Sep;72(3):688-93
Histologic atrial myolysis is associated with atrial fibrillation after cardiac operation.
Ad N, Snir E, Vidne BA, Golomb E
The Annals of thoracic surgery 2001 Sep;72(3):688-93
The Annals of thoracic surgery 2001 Sep;72(3):688-93
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression.
Makino Y, Cao R, Svensson K, Bertilsson G, Asman M, Tanaka H, Cao Y, Berkenstam A, Poellinger L
Nature 2001 Nov 29;414(6863):550-4
Nature 2001 Nov 29;414(6863):550-4
A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1alpha, 2alpha and 3alpha).
Luo JC, Shibuya M
Oncogene 2001 Mar 22;20(12):1435-44
Oncogene 2001 Mar 22;20(12):1435-44
Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis.
Alvarez-Tejado M, Naranjo-Suarez S, Jiménez C, Carrera AC, Landázuri MO, del Peso L
The Journal of biological chemistry 2001 Jun 22;276(25):22368-74
The Journal of biological chemistry 2001 Jun 22;276(25):22368-74
Role of exon 2-encoded beta -domain of the von Hippel-Lindau tumor suppressor protein.
Bonicalzi ME, Groulx I, de Paulsen N, Lee S
The Journal of biological chemistry 2001 Jan 12;276(2):1407-16
The Journal of biological chemistry 2001 Jan 12;276(2):1407-16
Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.
Haase VH, Glickman JN, Socolovsky M, Jaenisch R
Proceedings of the National Academy of Sciences of the United States of America 2001 Feb 13;98(4):1583-8
Proceedings of the National Academy of Sciences of the United States of America 2001 Feb 13;98(4):1583-8
Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis.
de Paulsen N, Brychzy A, Fournier MC, Klausner RD, Gnarra JR, Pause A, Lee S
Proceedings of the National Academy of Sciences of the United States of America 2001 Feb 13;98(4):1387-92
Proceedings of the National Academy of Sciences of the United States of America 2001 Feb 13;98(4):1387-92
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein.
Ohh M, Park CW, Ivan M, Hoffman MA, Kim TY, Huang LE, Pavletich N, Chau V, Kaelin WG
Nature cell biology 2000 Jul;2(7):423-7
Nature cell biology 2000 Jul;2(7):423-7
Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta.
Rajakumar A, Conrad KP
Biology of reproduction 2000 Aug;63(2):559-69
Biology of reproduction 2000 Aug;63(2):559-69
Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta.
Rajakumar A, Conrad KP
Biology of reproduction 2000 Aug;63(2):559-69
Biology of reproduction 2000 Aug;63(2):559-69
EPAS1 trans-activation during hypoxia requires p42/p44 MAPK.
Conrad PW, Freeman TL, Beitner-Johnson D, Millhorn DE
The Journal of biological chemistry 1999 Nov 19;274(47):33709-13
The Journal of biological chemistry 1999 Nov 19;274(47):33709-13
EPAS1 trans-activation during hypoxia requires p42/p44 MAPK.
Conrad PW, Freeman TL, Beitner-Johnson D, Millhorn DE
The Journal of biological chemistry 1999 Nov 19;274(47):33709-13
The Journal of biological chemistry 1999 Nov 19;274(47):33709-13
[Fibroxanthoma retroperitonei].
Biernat S
Wiadomosci lekarskie (Warsaw, Poland : 1960) 1976 May 1;29(9):845-8
Wiadomosci lekarskie (Warsaw, Poland : 1960) 1976 May 1;29(9):845-8
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Supportive validation
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- Simple Western: HIF-2 alpha/EPAS1 Antibody [NB100-122] - Image shows a specific band for HIF-2 alpha in 0.5 mg/mL of hypoxic HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.
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- Western Blot: HIF-2 alpha/EPAS1 Antibody [NB100-122] - HIF-2 alpha in MDA-MB-231 cell lysate (overexpression and endogenous samples) using . did not react to HIF-1 alpha overexpression. Image from verified customer review.
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- Western Blot: HIF-2 alpha/EPAS1 Antibody [NB100-122] - Lane 1: Cobalt chloride treated COS7 nuclear extracts. Lane 2: Untreated COS7 nuclear extracts.
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- Western Blot: HIF-2 alpha/EPAS1 Antibody [NB100-122] - 786-O cells without or with VHL overexpression. Image from verified customer review.
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- Western Blot: HIF-2 alpha/EPAS1 Antibody [NB100-122] - Human Glioma whole cell lysates. Image from verified customer review.
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- Western Blot: HIF-2 alpha/EPAS1 Antibody [NB100-122] - Analysis on normoxic and hypoxic nuclear rat cell lysates.
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- Western Blot: HIF-2 alpha/EPAS1 Antibody [NB100-122] - HIF-2 alpha in human retinal and choroidal primary endothelia lysates using .. Image from verified customer review.
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- Western Blot: HIF-2 alpha/EPAS1 Antibody [NB100-122] - Analysis using the HRP conjugate of NB100-122. Detection of normoxic and hypoxic nuclear rat cell lysates.
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- Western Blot: HIF-2 alpha/EPAS1 Antibody [NB100-122] - HIF2 expression in HIF2 over-expressed HEK 293T cells. Image from verified customer review.
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- Western Blot: HIF-2 alpha/EPAS1 Antibody [NB100-122] - Induced WNT11 expression with tumor hypoxia and WNT11 regulates tumor growth. Bevacizumab increased expression of HIF-1alpha and HIF-2alpha and WNT11. First 10 lanes are control tumors, and the last 10 lanes are tumors from bevacizumab-treated animals. Lysates from whole tissue and nuclei are indicated. Alpha -Tubulin, actin and lamin A/C are loading controls. Image collected and cropped by CiteAb from the following publication (http://www.nature.com/articles/srep21520) licensed under a CC-BY licence.
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- Western Blot: HIF-2 alpha/EPAS1 Antibody [NB100-122] - WNT11 is induced by hypoxia or hypoxic mimetics in different cell types. Immunoblot analyses of HeLa cells under normal air or hypoxia for 24 hrs. Image collected and cropped by CiteAb from the following publication (http://www.nature.com/articles/srep21520) licensed under a CC-BY licence.
Supportive validation
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- Immunohistochemistry-Paraffin: HIF-2 alpha/EPAS1 Antibody [NB100-122] - HIF-2 alpha immunoreactivity in human cardiac myocytes stained with NB100-122.
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- Immunohistochemistry: HIF-2 alpha/EPAS1 Antibody [NB100-122] - Expression and correlation of 3 antibodies: HIF-1 alpha, HIF-2 alpha and HAF in ccRCC. (A, C & E) Positive nuclear staining to the 3 antibodies: HIF-1 alpha, HIF-2 alpha and HAF, in primary ccRCCs at high magnification (100X). (B, D & F) Heterogenous nuclear staining of 3 antibodies in a tumor at low magnification (20X). (G, H and I). Correlation of 3 antibodies with the Fuhrman grade. Citation: Ambrosetti D, Dufies M, Dadone B, Durand M, Borchiellini D, Amiel J, et al. (2018) The two glycolytic markers GLUT1 and MCT1 correlate with tumor grade and survival in clear-cell renal cell carcinoma. PLoS ONE 13(2): e0193477. https://doi.org/10.1371/journal.pone.0193477
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- Immunohistochemistry: HIF-2 alpha/EPAS1 Antibody [NB100-122] - Expression of hypoxia-inducible alpha subunits in normal and diseased lung tissue. HIF-2alpha expression are more evident in fibroblasts from idiopathic pulmonary fibrosis (d) than from lung tissue affected by other inflammatory conditions (i.e. chronic bronchitis, panel e) or normal lung tissue (f); as demonstrated by a higher proportion of positive fibroblasts (open arrows) than negative ones (solid black arrows). Image collected and cropped by CiteAb from the following publication (https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-019-1100-4) licensed under a CC-BY licence.
Supportive validation
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- Chromatin Immunoprecipitation: HIF-2 alpha/EPAS1 Antibody [NB100-122] - MCF7 cells were exposed to 20% or 1% O2 for 16h, and ChIP assays were performed using IgG or antibodies against HIF-1a, HIF-2a, HIF-1b. Image from verified customer review.
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- Chromatin Immunoprecipitation: HIF-2 alpha/EPAS1 Antibody [NB100-122] - MDA-MB-231 cells were exposed to 20% or 1% O2 for 16 hours, and chromatin immunoprecipitation (ChIP) was performed with the indicated antibody (Ab). Primers flanking the HIF binding site were used for qPCR. ChIP image submitted by a verified customer review.
