Antibody data
- Antibody Data
- Antigen structure
- References [30]
- Comments [0]
- Validations [0]
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- Product number
- 26422-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- EPAS1 antibody
- Antibody type
- Polyclonal
- Description
- EPAS1 antibody (Cat. #26422-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Transcriptional mechanisms of hearing acclimatization to high altitude in rats.
ZNF395 Is a Hypoxia-Responsive Regulator of Mitochondrial Glutaminolysis in Clear Cell Renal Cell Carcinoma.
Belzutifan Attenuates Choroidal Neovascularization by Suppressing the HIF-2α/PAI-1 Axis.
ACSS2 promotes proliferation and invasiveness of SKOV-3 and PA-1 ovarian cancer cell lines under hypoxia.
Mechanism of retinal angiogenesis induced by HIF-1α and HIF-2α under hyperoxic conditions.
Identified endoplasmic reticulum stress-related molecular cluster and immune characterization in endometriosis.
EPAS1 increases SDHA to inhibit proliferation of multiple myeloma cells by restoring TCA Cycle.
LRRK2 reduces the sensitivity to TKI and PD-1 blockade in ccRCC via activating LPCAT1.
Proteomic analysis reveals proteins and pathways associated with the effects of Hippophae rhamnoides L. total flavonoids on ameliorating excessive erythropoiesis in high-altitude polycythemia mice.
Hypoxia ameliorates high-fat-diet-induced hepatic lipid accumulation by modulating the HIF2α/PP4C signaling.
Identification and Validation of Epithelial Cell Centre Regulatory Transcription Factors in the Gastric Cancer Microenvironment.
Enhanced glioma cell death with ZnO nanorod flowers and temozolomide combination therapy through autophagy and mitophagy pathways.
HDAC8 Enhances the Function of HIF-2α by Deacetylating ETS1 to Decrease the Sensitivity of TKIs in ccRCC.
IHH-GLI-1-HIF-2α signalling influences hypertrophic chondrocytes to exacerbate osteoarthritis progression.
Hypoxia-inducible factor 3α1 increases epithelial-to-mesenchymal transition and iron uptake to drive colorectal cancer liver metastasis.
Deciphering ER stress-unfolded protein response relationship by visualizing unfolded proteins in the ER.
CGG repeats in the human FMR1 gene regulate mRNA localization and cellular stress in developing neurons.
Induction of the Mdm2 gene and protein by kinase signaling pathways is repressed by the pVHL tumor suppressor.
β-hydroxybutyrate restrains colitis-associated tumorigenesis by inhibiting HIF-1α-mediated angiogenesis.
The Interplay Between HIF-1α and EZH2 in Lung Cancer and Dual-Targeted Drug Therapy.
OTUB1 Catalytic-Independently Deubiquitinates TGFBI and Mediates the Angiogenesis in Infantile Hemangioma by Regulating Glycolysis.
Development of VHL-recruiting STING PROTACs that suppress innate immunity.
STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity.
14-3-3σ-NEDD4L axis promotes ubiquitination and degradation of HIF-1α in colorectal cancer.
Regulatory mechanisms and function of hypoxia-induced long noncoding RNA NDRG1-OT1 in breast cancer cells.
Organophosphate flame retardant TDCPP: A risk factor for renal cancer?
Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway.
Establishment of Patient-Derived Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor Models for Predicting Therapeutic Response.
MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2α-CYR61 axis.
Acidic Microenvironment Up-Regulates Exosomal miR-21 and miR-10b in Early-Stage Hepatocellular Carcinoma to Promote Cancer Cell Proliferation and Metastasis.
Awang D, Danzeng K, Ren H, Da Z, Gesang Q, Deji Q, Xie H, Liu X, Zhao B, Gongga L
Scientific reports 2026 Jan 5;16(1):4223
Scientific reports 2026 Jan 5;16(1):4223
ZNF395 Is a Hypoxia-Responsive Regulator of Mitochondrial Glutaminolysis in Clear Cell Renal Cell Carcinoma.
Koh J, Liao C, Ng MSW, Hong JH, Heng HL, Gui DY, Wang Z, Chua BY, Li Z, Sobota RM, Lee LS, Iqbal J, Lim KJ, Bezwada D, DeBerardinis RJ, Steger G, Ching J, Tan P, Teh BT, Zhang Q, Yao X
Cancer research 2026 Apr 2;86(7):1676-1689
Cancer research 2026 Apr 2;86(7):1676-1689
Belzutifan Attenuates Choroidal Neovascularization by Suppressing the HIF-2α/PAI-1 Axis.
Lin Y, Du Y, Shu Q, Su W, Peng H, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 15;40(7):e71740
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 15;40(7):e71740
ACSS2 promotes proliferation and invasiveness of SKOV-3 and PA-1 ovarian cancer cell lines under hypoxia.
Mroweh O, Karam L, Hammoud R, Al Achcar J, Sobh R, Nasser SM, Garcia JA, Kobeissy PH
Journal of ovarian research 2025 Oct 31;18(1):232
Journal of ovarian research 2025 Oct 31;18(1):232
Mechanism of retinal angiogenesis induced by HIF-1α and HIF-2α under hyperoxic conditions.
Feng X, Li C, Zhang W, Jiao K, Zhang L, Xiao L
Scientific reports 2025 Oct 15;15(1):36049
Scientific reports 2025 Oct 15;15(1):36049
Identified endoplasmic reticulum stress-related molecular cluster and immune characterization in endometriosis.
Huang E, Zhang L, Lou J, Wang X, Chen L
Scientific reports 2025 Nov 4;15(1):38553
Scientific reports 2025 Nov 4;15(1):38553
EPAS1 increases SDHA to inhibit proliferation of multiple myeloma cells by restoring TCA Cycle.
Sun Y, Maihemaiti A, Xu Z, Tang L, Wang Y, Jiang J, Zhou H, Pan C, Pang Y, Liu P
NPJ precision oncology 2025 Nov 25;9(1):406
NPJ precision oncology 2025 Nov 25;9(1):406
LRRK2 reduces the sensitivity to TKI and PD-1 blockade in ccRCC via activating LPCAT1.
Hong Y, Li W, Xing Z, Lu M, Tang T, Zhu L, Xiong W, Zhang H, Liu W, Ren S
Oncogene 2025 Jun;44(22):1761-1776
Oncogene 2025 Jun;44(22):1761-1776
Proteomic analysis reveals proteins and pathways associated with the effects of Hippophae rhamnoides L. total flavonoids on ameliorating excessive erythropoiesis in high-altitude polycythemia mice.
Liu F, Li T, Shao Y, Dong Z, Kong F, Liu Z, Tian H
Journal of ethnopharmacology 2025 Jun 26;350:119996
Journal of ethnopharmacology 2025 Jun 26;350:119996
Hypoxia ameliorates high-fat-diet-induced hepatic lipid accumulation by modulating the HIF2α/PP4C signaling.
Liu Z, Hou J, Tian M, Zhang Y, Huang D, Zhao N, Ma Y, Cui S
Cellular signalling 2025 Jul;131:111751
Cellular signalling 2025 Jul;131:111751
Identification and Validation of Epithelial Cell Centre Regulatory Transcription Factors in the Gastric Cancer Microenvironment.
Su G, Wang J, Liu S, Fu X, Li Y, Pan G
International journal of general medicine 2024;17:6567-6584
International journal of general medicine 2024;17:6567-6584
Enhanced glioma cell death with ZnO nanorod flowers and temozolomide combination therapy through autophagy and mitophagy pathways.
Li Y, Ma Y, Li J, Lu Y, Liu H, Gao M, Cao J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117149
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117149
HDAC8 Enhances the Function of HIF-2α by Deacetylating ETS1 to Decrease the Sensitivity of TKIs in ccRCC.
Qian K, Li W, Ren S, Peng W, Qing B, Liu X, Wei X, Zhu L, Wang Y, Jin X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(36):e2401142
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(36):e2401142
IHH-GLI-1-HIF-2α signalling influences hypertrophic chondrocytes to exacerbate osteoarthritis progression.
Zhang C, Zhao R, Dong Z, Liu Y, Liu M, Li H, Yin Y, Che X, Wu G, Li Guo, Li P, Wei X, Yang Z
Journal of orthopaedic translation 2024 Nov;49:207-217
Journal of orthopaedic translation 2024 Nov;49:207-217
Hypoxia-inducible factor 3α1 increases epithelial-to-mesenchymal transition and iron uptake to drive colorectal cancer liver metastasis.
Villareal LB, Falcon DM, Xie L, Xue X
British journal of cancer 2024 Jun;130(12):1904-1915
British journal of cancer 2024 Jun;130(12):1904-1915
Deciphering ER stress-unfolded protein response relationship by visualizing unfolded proteins in the ER.
Xu F, Wang L
Cell reports 2024 Jun 25;43(6):114358
Cell reports 2024 Jun 25;43(6):114358
CGG repeats in the human FMR1 gene regulate mRNA localization and cellular stress in developing neurons.
Sirois CL, Guo Y, Li M, Wolkoff NE, Korabelnikov T, Sandoval S, Lee J, Shen M, Contractor A, Sousa AMM, Bhattacharyya A, Zhao X
Cell reports 2024 Jun 25;43(6):114330
Cell reports 2024 Jun 25;43(6):114330
Induction of the Mdm2 gene and protein by kinase signaling pathways is repressed by the pVHL tumor suppressor.
Mabry AR, Singh A, Mulrooney B, Gorman J, Thielbar AR, Wolf ER, Mayo LD
Proceedings of the National Academy of Sciences of the United States of America 2024 Jul 30;121(31):e2400935121
Proceedings of the National Academy of Sciences of the United States of America 2024 Jul 30;121(31):e2400935121
β-hydroxybutyrate restrains colitis-associated tumorigenesis by inhibiting HIF-1α-mediated angiogenesis.
Huang C, Tan H, Wang J, Huang L, Liu H, Shi Y, Zhong C, Weng S, Chen C, Zhao W, Lin Z, Li J, Zhi F, Zhang B
Cancer letters 2024 Jul 1;593:216940
Cancer letters 2024 Jul 1;593:216940
The Interplay Between HIF-1α and EZH2 in Lung Cancer and Dual-Targeted Drug Therapy.
Wang J, Yang C, Xu H, Fan X, Jia L, Du Y, Liu S, Wang W, Zhang J, Zhang Y, Wang X, Liu Z, Bao J, Li S, Yang J, Wu C, Tang J, Chen G, Wang L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2303904
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2303904
OTUB1 Catalytic-Independently Deubiquitinates TGFBI and Mediates the Angiogenesis in Infantile Hemangioma by Regulating Glycolysis.
Li M, Wang X, Yang E, Li Y, Geng Y, Chen Z, Huang S, Zhang D, Wu H
Arteriosclerosis, thrombosis, and vascular biology 2023 May;43(5):654-673
Arteriosclerosis, thrombosis, and vascular biology 2023 May;43(5):654-673
Development of VHL-recruiting STING PROTACs that suppress innate immunity.
Zhu Z, Johnson RL, Zhang Z, Herring LE, Jiang G, Damania B, James LI, Liu P
Cellular and molecular life sciences : CMLS 2023 May 14;80(6):149
Cellular and molecular life sciences : CMLS 2023 May 14;80(6):149
STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity.
Zhu Z, Zhou X, Du H, Cloer EW, Zhang J, Mei L, Wang Y, Tan X, Hepperla AJ, Simon JM, Cook JG, Major MB, Dotti G, Liu P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jan;10(3):e2203718
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jan;10(3):e2203718
14-3-3σ-NEDD4L axis promotes ubiquitination and degradation of HIF-1α in colorectal cancer.
Liu S, Guo R, Xu H, Yang J, Luo H, Yeung SJ, Li K, Lee MH, Yang R
Cell reports 2023 Aug 29;42(8):112870
Cell reports 2023 Aug 29;42(8):112870
Regulatory mechanisms and function of hypoxia-induced long noncoding RNA NDRG1-OT1 in breast cancer cells.
Chao HH, Luo JL, Hsu MH, Chen LH, Lu TP, Tsai MH, Chuang EY, Chuang LL, Lai LC
Cell death & disease 2022 Sep 20;13(9):807
Cell death & disease 2022 Sep 20;13(9):807
Organophosphate flame retardant TDCPP: A risk factor for renal cancer?
Zhou X, Zhou X, Yao L, Zhang X, Cong R, Luan J, Zhang T, Song N
Chemosphere 2022 Oct;305:135485
Chemosphere 2022 Oct;305:135485
Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway.
Song CC, Pantopoulos K, Chen GH, Zhong CC, Zhao T, Zhang DG, Luo Z
Cellular and molecular life sciences : CMLS 2022 Jul 4;79(7):394
Cellular and molecular life sciences : CMLS 2022 Jul 4;79(7):394
Establishment of Patient-Derived Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumor Models for Predicting Therapeutic Response.
Yebra M, Bhargava S, Kumar A, Burgoyne AM, Tang CM, Yoon H, Banerjee S, Aguilera J, Cordes T, Sheth V, Noh S, Ustoy R, Li S, Advani SJ, Corless CL, Heinrich MC, Kurzrock R, Lippman SM, Fanta PT, Harismendy O, Metallo C, Sicklick JK
Clinical cancer research : an official journal of the American Association for Cancer Research 2022 Jan 1;28(1):187-200
Clinical cancer research : an official journal of the American Association for Cancer Research 2022 Jan 1;28(1):187-200
MIIP inhibits clear cell renal cell carcinoma proliferation and angiogenesis via negative modulation of the HIF-2α-CYR61 axis.
Yan F, Wang Q, Xia M, Ru Y, Hu W, Yan G, Xiong X, Zhang M, Wang J, Li Q, Zhang B, Wang H, Lin W, Wu G, Li X
Cancer biology & medicine 2021 Dec 22;19(6):818-35
Cancer biology & medicine 2021 Dec 22;19(6):818-35
Acidic Microenvironment Up-Regulates Exosomal miR-21 and miR-10b in Early-Stage Hepatocellular Carcinoma to Promote Cancer Cell Proliferation and Metastasis.
Tian XP, Wang CY, Jin XH, Li M, Wang FW, Huang WJ, Yun JP, Xu RH, Cai QQ, Xie D
Theranostics 2019;9(7):1965-1979
Theranostics 2019;9(7):1965-1979
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