BS5775

antibody from Bioworld Technology, Inc

Targeting: KCNJ5 CIR, GIRK4, KATP1, Kir3.4, LQT13

Immunocytochemistry

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Validation data

Product number: BS5775 - Provider product page
Provider: Bioworld Technology, Inc
Product name: KIR3.4 polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic peptide, corresponding to the 374-419 of Human KIR3.4.
Description: G protein-coupled inwardly rectifying potassium channels (Kir3.1 through Kir3.4) are coupled to numerous neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex and thalamus regions of the brain. Also known as GIRK, Kir3 potassium channels localize to the soma and dendrites as well as axons of neurons. Liberated Gbg subunits from G protein heterotrimers bind to and regulate Kir3 channel activity. Gb3- and Gb4-containing Gbg dimers bind directly to cytoplasmic domains of Kir3 proteins and increase the K+ current while Gb5-containing Gbg dimers inhibit Kir3 K+ current. Kir3 activity is also inhibited by tyrosine phosphorylation. Brain-derived neurotrophic factor activates receptor tyrosine kinase B, which then phosphorylates Kir3 tyrosine residues, effectively inactivating the Kir3 channels.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

KCNJ5 protein structure - BS5775 shown in red.