Antibody data
- Antibody Data
- Antigen structure
- References [15]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 11229-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11229-1-AP, RRID:AB_2140681
- Product name
- MAP4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MAP4 antibody (Cat. #11229-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Protein interaction networks in the vasculature prioritize genes and pathways underlying coronary artery disease.
MAP4 acts as an oncogene and prognostic marker and affects radioresistance by mediating epithelial-mesenchymal transition in lung adenocarcinoma.
Ste20-Like Kinase TAOK1 Positively Regulates Antiviral Responses by Controlling the TBK1-IRF3 Signaling Axis.
Microtubule-associated protein 4 promotes epithelial mesenchymal transition in hepatocellular cancer cells via regulating GSK3β/β-catenin pathway.
FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation.
Coiled-coil domain-containing 154 promotes colorectal cancer proliferation and metastasis via interacting with minichromosome maintenance complex component 2.
Comparative Proteomic Analysis Reveals the Effect of Selenoprotein W Deficiency on Oligodendrogenesis in Fear Memory.
Interactome screening of C9orf72 dipeptide repeats reveals VCP sequestration and functional impairment by polyGA.
Cadmium induces endosomal/lysosomal enlargement and blocks autophagy flux in rat hepatocytes by damaging microtubules.
The molecular chaperone Hsp90 maintains Golgi organization and vesicular trafficking by regulating microtubule stability.
Microtubule-Associated Protein 4 Is a Prognostic Factor and Promotes Tumor Progression in Lung Adenocarcinoma.
Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy.
Rabies Virus Infection Induces Microtubule Depolymerization to Facilitate Viral RNA Synthesis by Upregulating HDAC6.
Microtubule-associated protein 4 is an important regulator of cell invasion/migration and a potential therapeutic target in esophageal squamous cell carcinoma.
Activation of cyclic AMP/PKA pathway inhibits bladder cancer cell invasion by targeting MAP4-dependent microtubule dynamics.
Zhu QM, Hsu YH, Lassen FH, MacDonald BT, Stead S, Malolepsza E, Kim A, Li T, Mizoguchi T, Schenone M, Guzman G, Tanenbaum B, Fornelos N, Carr SA, Gupta RM, Ellinor PT, Lage K
Communications biology 2024 Jan 12;7(1):87
Communications biology 2024 Jan 12;7(1):87
MAP4 acts as an oncogene and prognostic marker and affects radioresistance by mediating epithelial-mesenchymal transition in lung adenocarcinoma.
Xia X, Ge Y, Ge F, Gu P, Liu Y, Li P, Xu P
Journal of cancer research and clinical oncology 2024 Feb 10;150(2):88
Journal of cancer research and clinical oncology 2024 Feb 10;150(2):88
Ste20-Like Kinase TAOK1 Positively Regulates Antiviral Responses by Controlling the TBK1-IRF3 Signaling Axis.
Luo X, Ji R, Liu Q, Xiao X, Song W, An H, Li Y, Zhou J
Journal of innate immunity 2023;15(1):380-396
Journal of innate immunity 2023;15(1):380-396
Microtubule-associated protein 4 promotes epithelial mesenchymal transition in hepatocellular cancer cells via regulating GSK3β/β-catenin pathway.
Hu P, Zong B, Chen Q, Shao R, Chen M, Yang Y, Shao G
Heliyon 2023 Mar;9(3):e14309
Heliyon 2023 Mar;9(3):e14309
FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation.
Pan Y, Liu J, Gao Y, Guo Y, Wang C, Liang Z, Wu M, Qian Y, Li Y, Shen J, Lu C, Ma S
Journal of experimental & clinical cancer research : CR 2023 Mar 29;42(1):75
Journal of experimental & clinical cancer research : CR 2023 Mar 29;42(1):75
Coiled-coil domain-containing 154 promotes colorectal cancer proliferation and metastasis via interacting with minichromosome maintenance complex component 2.
Hong WF, Zhu DX, Chen YJ, Shen XZ, Cui YH, Du SS, Liu TS, Liang L
Cancer letters 2023 Dec 1;578:216460
Cancer letters 2023 Dec 1;578:216460
Comparative Proteomic Analysis Reveals the Effect of Selenoprotein W Deficiency on Oligodendrogenesis in Fear Memory.
Situ J, Huang X, Zuo M, Huang Y, Ren B, Liu Q
Antioxidants (Basel, Switzerland) 2022 May 19;11(5)
Antioxidants (Basel, Switzerland) 2022 May 19;11(5)
Interactome screening of C9orf72 dipeptide repeats reveals VCP sequestration and functional impairment by polyGA.
Božič J, Motaln H, Janež AP, Markič L, Tripathi P, Yamoah A, Aronica E, Lee YB, Heilig R, Fischer R, Thompson AJ, Goswami A, Rogelj B
Brain : a journal of neurology 2022 Apr 18;145(2):684-699
Brain : a journal of neurology 2022 Apr 18;145(2):684-699
Cadmium induces endosomal/lysosomal enlargement and blocks autophagy flux in rat hepatocytes by damaging microtubules.
Yuan J, Zhao Y, Bai Y, Gu J, Yuan Y, Liu X, Liu Z, Zou H, Bian J
Ecotoxicology and environmental safety 2021 Nov 19;228:112993
Ecotoxicology and environmental safety 2021 Nov 19;228:112993
The molecular chaperone Hsp90 maintains Golgi organization and vesicular trafficking by regulating microtubule stability.
Wu Y, Ding Y, Zheng X, Liao K
Journal of molecular cell biology 2020 Jul 3;12(6):448-461
Journal of molecular cell biology 2020 Jul 3;12(6):448-461
Microtubule-Associated Protein 4 Is a Prognostic Factor and Promotes Tumor Progression in Lung Adenocarcinoma.
Xia X, He C, Wu A, Zhou J, Wu J
Disease markers 2018;2018:8956072
Disease markers 2018;2018:8956072
Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy.
Allen M, Wang X, Serie DJ, Strickland SL, Burgess JD, Koga S, Younkin CS, Nguyen TT, Malphrus KG, Lincoln SJ, Alamprese M, Zhu K, Chang R, Carrasquillo MM, Kouri N, Murray ME, Reddy JS, Funk C, Price ND, Golde TE, Younkin SG, Asmann YW, Crook JE, Dickson DW, Ertekin-Taner N
Acta neuropathologica 2018 Nov;136(5):709-727
Acta neuropathologica 2018 Nov;136(5):709-727
Rabies Virus Infection Induces Microtubule Depolymerization to Facilitate Viral RNA Synthesis by Upregulating HDAC6.
Zan J, Liu S, Sun DN, Mo KK, Yan Y, Liu J, Hu BL, Gu JY, Liao M, Zhou JY
Frontiers in cellular and infection microbiology 2017;7:146
Frontiers in cellular and infection microbiology 2017;7:146
Microtubule-associated protein 4 is an important regulator of cell invasion/migration and a potential therapeutic target in esophageal squamous cell carcinoma.
Jiang YY, Shang L, Shi ZZ, Zhang TT, Ma S, Lu CC, Zhang Y, Hao JJ, Shi C, Shi F, Xu X, Cai Y, Jia XM, Zhan QM, Wang MR
Oncogene 2016 Sep 15;35(37):4846-56
Oncogene 2016 Sep 15;35(37):4846-56
Activation of cyclic AMP/PKA pathway inhibits bladder cancer cell invasion by targeting MAP4-dependent microtubule dynamics.
Ou Y, Zheng X, Gao Y, Shu M, Leng T, Li Y, Yin W, Zhu W, Huang Y, Zhou Y, Tang J, Qiu P, Yan G, Hu J, Ruan H, Hu H
Urologic oncology 2014 Jan;32(1):47.e21-8
Urologic oncology 2014 Jan;32(1):47.e21-8
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 11229-1-AP( MAP4 Antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MAP4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MAP4. This antibody recognizes human,mouse,rat antigen. The MAP4 antibody has been validated for the following applications: ELISA, IHC, WB analysis.