11229-1-AP

antibody from Proteintech Group

Targeting: MAP4

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

11229-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#11229-1-AP, RRID:AB_2140681

Product name

MAP4 antibody

Antibody type

Polyclonal

Description

KD/KO validated MAP4 antibody (Cat. #11229-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Reversibly unlocking the blood-brain barrier: A study on microtubule dynamics modulation using gold nanoparticle-modified reduced graphene oxide.

Wu J, Cui G, Lin Z, Lin W, Zhang Y, Zhou T, He P, Zhang Y, Yao G
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1676-1695

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Integrative bioinformatics and machine learning identify iron metabolism genes MAP4, GPT, and HIRIP3 as diagnostic biomarkers and therapeutic targets in Alzheimer's disease.

An X, Zeng X, Yi Z, Cao M, Wang Y, Yu W, Ren Z
Frontiers in cellular neuroscience 2025;19:1610682

---

Rhein Mitigates Lung Injury in Severe Acute Pancreatitis Through the Inhibition of MARK4-Mediated Microtubule Destabilization.

Sun Z, Liu J, Ge P, Cao Y, Liu J, Wen H, Luo X, Pei B, Jin Z, Li H, Xun L, Luo Y, Yang Q, Chen H
Journal of inflammation research 2025;18:1395-1412

---

Hyperosmotic stimuli activate polycystin proteins to aid in urine concentration.

Márquez-Nogueras KM, Knutila RM, Vuchkovska V, Yang C, Outeda P, Wallace DP, Kuo IY
JCI insight 2025 Sep 23;10(18)

---

Rufy3 Knockdown Induces PANoptosis Through MAP4/CDK1 Axis to Inhibit Colorectal Cancer Growth: Evidence From In Vitro and In Vivo Models.

Xie R, Yuan W, Chen X, Hao A, Wu Y, Zhang B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 15;39(17):e70988

---

Divergent proteome tolerance against gain and loss of chromosome arms.

Di Y, Li W, Castellano JJ, Jin W, Modi JN, Salovska B, Khosroabadi D, Hu W, Taylor AM, Liu Y
Molecular cell 2025 Nov 20;85(22):4268-4278.e6

---

FGF13 regulates cardiomyocyte impulse propagation via Cx43 trafficking independent of voltage-gated sodium channels.

Das LT, Malvezzi M, Gade A, Matsui M, McKay M, Wei EQ, Zelich MJ, Mazdisnian K, Kushner J, Chen BX, DiStefano I, Roybal D, Yang L, Stoll L, Lo JC, Kalocsay M, Akar FG, Marx SO, Pitt GS
bioRxiv : the preprint server for biology 2025 Jul 27;

---

ARIH1 Inhibition Promotes Microtubule Stability and Sensitizes Breast Cancer Cells to Microtubule-Stabilizing Agents.

Elshaer M, Howley BV, Howe PH
Cancers 2025 Feb 25;17(5)

---

Tks5 interactome reveals endoplasmic-reticulum-associated translation machinery in invadosomes.

Normand L, Bonnard B, Sala M, Di Tommaso S, Dourthe C, Raymond AA, Dupuy JW, Mercier L, Goetz JG, Moreau V, Henriet E, Saltel F
The FEBS journal 2025 Dec;292(23):6400-6419

---

MAP4 phosphorylation induced by ARID1A loss sensitizes colorectal cancer cells to EMP.

Pan L, Wu D, He Y, Wang K, Zeng Y, Xiang C, Huang L, Qin W, Zhang X, Wang Z, Yu Y, Wang Z, Xiang L, Wu C, Li A
Cell death & disease 2025 Dec 8;17(1):83

---

FGF13 Regulates VGSC-Independent Cardiomyocyte Impulse Propagation via Cx43 Trafficking.

Das LT, Malvezzi M, Gade AR, Matsui M, McKay M, Wei EQ, Zelich MJ, Mazdisnian K, Kushner J, Chen BX, DiStefano I, Roybal D, Yang L, Stoll L, Lo JC, Kalocsay M, Akar FG, Marx SO, Pitt GS
Circulation research 2025 Dec 5;137(12):1522-1539

---

Protein arginine methyltransferase 1 stimulates basal cell proliferation and migration to maintain corneal epithelial homeostasis.

Yang J, Hu M, Yang M, Ni H, Zhou J, Li D, Ran J, Liu M
Cell death discovery 2025 Aug 15;11(1):385

---

Protein interaction networks in the vasculature prioritize genes and pathways underlying coronary artery disease.

Zhu QM, Hsu YH, Lassen FH, MacDonald BT, Stead S, Malolepsza E, Kim A, Li T, Mizoguchi T, Schenone M, Guzman G, Tanenbaum B, Fornelos N, Carr SA, Gupta RM, Ellinor PT, Lage K
Communications biology 2024 Jan 12;7(1):87

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MAP4 acts as an oncogene and prognostic marker and affects radioresistance by mediating epithelial-mesenchymal transition in lung adenocarcinoma.

Xia X, Ge Y, Ge F, Gu P, Liu Y, Li P, Xu P
Journal of cancer research and clinical oncology 2024 Feb 10;150(2):88

---

Ste20-Like Kinase TAOK1 Positively Regulates Antiviral Responses by Controlling the TBK1-IRF3 Signaling Axis.

Luo X, Ji R, Liu Q, Xiao X, Song W, An H, Li Y, Zhou J
Journal of innate immunity 2023;15(1):380-396

---

Microtubule-associated protein 4 promotes epithelial mesenchymal transition in hepatocellular cancer cells via regulating GSK3β/β-catenin pathway.

Hu P, Zong B, Chen Q, Shao R, Chen M, Yang Y, Shao G
Heliyon 2023 Mar;9(3):e14309

---

FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation.

Pan Y, Liu J, Gao Y, Guo Y, Wang C, Liang Z, Wu M, Qian Y, Li Y, Shen J, Lu C, Ma S
Journal of experimental & clinical cancer research : CR 2023 Mar 29;42(1):75

---

Coiled-coil domain-containing 154 promotes colorectal cancer proliferation and metastasis via interacting with minichromosome maintenance complex component 2.

Hong WF, Zhu DX, Chen YJ, Shen XZ, Cui YH, Du SS, Liu TS, Liang L
Cancer letters 2023 Dec 1;578:216460

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Comparative Proteomic Analysis Reveals the Effect of Selenoprotein W Deficiency on Oligodendrogenesis in Fear Memory.

Situ J, Huang X, Zuo M, Huang Y, Ren B, Liu Q
Antioxidants (Basel, Switzerland) 2022 May 19;11(5)

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Interactome screening of C9orf72 dipeptide repeats reveals VCP sequestration and functional impairment by polyGA.

Božič J, Motaln H, Janež AP, Markič L, Tripathi P, Yamoah A, Aronica E, Lee YB, Heilig R, Fischer R, Thompson AJ, Goswami A, Rogelj B
Brain : a journal of neurology 2022 Apr 18;145(2):684-699

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Cadmium induces endosomal/lysosomal enlargement and blocks autophagy flux in rat hepatocytes by damaging microtubules.

Yuan J, Zhao Y, Bai Y, Gu J, Yuan Y, Liu X, Liu Z, Zou H, Bian J
Ecotoxicology and environmental safety 2021 Nov 19;228:112993

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The molecular chaperone Hsp90 maintains Golgi organization and vesicular trafficking by regulating microtubule stability.

Wu Y, Ding Y, Zheng X, Liao K
Journal of molecular cell biology 2020 Jul 3;12(6):448-461

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Microtubule-Associated Protein 4 Is a Prognostic Factor and Promotes Tumor Progression in Lung Adenocarcinoma.

Xia X, He C, Wu A, Zhou J, Wu J
Disease markers 2018;2018:8956072

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Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy.

Allen M, Wang X, Serie DJ, Strickland SL, Burgess JD, Koga S, Younkin CS, Nguyen TT, Malphrus KG, Lincoln SJ, Alamprese M, Zhu K, Chang R, Carrasquillo MM, Kouri N, Murray ME, Reddy JS, Funk C, Price ND, Golde TE, Younkin SG, Asmann YW, Crook JE, Dickson DW, Ertekin-Taner N
Acta neuropathologica 2018 Nov;136(5):709-727

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Rabies Virus Infection Induces Microtubule Depolymerization to Facilitate Viral RNA Synthesis by Upregulating HDAC6.

Zan J, Liu S, Sun DN, Mo KK, Yan Y, Liu J, Hu BL, Gu JY, Liao M, Zhou JY
Frontiers in cellular and infection microbiology 2017;7:146

---

Microtubule-associated protein 4 is an important regulator of cell invasion/migration and a potential therapeutic target in esophageal squamous cell carcinoma.

Jiang YY, Shang L, Shi ZZ, Zhang TT, Ma S, Lu CC, Zhang Y, Hao JJ, Shi C, Shi F, Xu X, Cai Y, Jia XM, Zhan QM, Wang MR
Oncogene 2016 Sep 15;35(37):4846-56

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A panel of protein markers for the early detection of lung cancer with bronchial brushing specimens.

Liu YZ, Jiang YY, Wang BS, Hao JJ, Shang L, Zhang TT, Cao J, Xu X, Zhan QM, Wang MR
Cancer cytopathology 2014 Nov;122(11):833-41

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Activation of cyclic AMP/PKA pathway inhibits bladder cancer cell invasion by targeting MAP4-dependent microtubule dynamics.

Ou Y, Zheng X, Gao Y, Shu M, Leng T, Li Y, Yin W, Zhu W, Huang Y, Zhou Y, Tang J, Qiu P, Yan G, Hu J, Ruan H, Hu H
Urologic oncology 2014 Jan;32(1):47.e21-8

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

HEK-293 cells were subjected to SDS PAGE followed by western blot with 11229-1-AP( MAP4 Antibody) at dilution of 1:600

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The MAP4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MAP4. This antibody recognizes human,mouse,rat antigen. The MAP4 antibody has been validated for the following applications: ELISA, IHC, WB analysis.

Appendix

11229-1-AP.pdf

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