351104

antibody from BioLegend

Targeting: TREML2 C6orf76, dJ238O23.1, FLJ13693, TLT2

Antibody data

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Validation data

Product number: 351104 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#351104, RRID:AB_10722614
Product name: PE anti-human TLT-2
Antibody type: Monoclonal
Antigen: Human TLT-2
Description: Trem-like transcript 2 protein (TLT2), also known as TREML2, is a 33 kD (unglycosylated) type I transmembrane protein with a single IgV domain containing two potential N-glycosylation sites, a serine/threonine-rich region with numerous predicted O-linked glycosylation sites, a single membrane-spanning region, and a short cytoplasmic tail. TLT2 is expressed on B lineage cells, macrophages, and neutrophils in bone marrow and periphery, and the expression level can be upregulated in response to inflammation. As a receptor, TLT2 likely plays a role in innate immunity. Recent studies have demonstrated that ligation of TLT2 inhibits the oxidative burst in neutrophils upon fMLP stimulation, indicating that TLT2 may function as an inhibitory receptor that attenuates activation of neutrophils and possibly macrophages. Recently, TLT-2 protein has been found on CD8+ T cells and is induced on activated CD4+ T cells.
Reactivity: Human
Host: Mouse
Conjugate: Yellow dye
Isotype: IgG
Vial size: 100 tests
Storage: The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

TREML2 protein structure - 351104 shown in red.