Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 351104 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#351104, RRID:AB_10722614
- Product name
- PE anti-human TLT-2
- Antibody type
- Monoclonal
- Antigen
- Human TLT-2
- Description
- Trem-like transcript 2 protein (TLT2), also known as TREML2, is a 33 kD (unglycosylated) type I transmembrane protein with a single IgV domain containing two potential N-glycosylation sites, a serine/threonine-rich region with numerous predicted O-linked glycosylation sites, a single membrane-spanning region, and a short cytoplasmic tail. TLT2 is expressed on B lineage cells, macrophages, and neutrophils in bone marrow and periphery, and the expression level can be upregulated in response to inflammation. As a receptor, TLT2 likely plays a role in innate immunity. Recent studies have demonstrated that ligation of TLT2 inhibits the oxidative burst in neutrophils upon fMLP stimulation, indicating that TLT2 may function as an inhibitory receptor that attenuates activation of neutrophils and possibly macrophages. Recently, TLT-2 protein has been found on CD8+ T cells and is induced on activated CD4+ T cells.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Yellow dye
- Isotype
- IgG
- Vial size
- 100 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood granulocytes were stained with TLT2 (clone MIH61) PE (filled histogram) or mouse IgG2b PE isotype control (open histogram).
- Conjugate
- Yellow dye