351203

antibody from BioLegend
Targeting: TREML2 C6orf76, dJ238O23.1, FLJ13693, TLT2
Provider product page for 351203

Antibody data

Product number
351203 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#351203, RRID:AB_10933423
Product name
PE anti-human TLT-2
Antibody type
Monoclonal
Antigen
Human TLT-2
Description
Trem-like transcript 2 protein (TLT2), also known as TREML2, is a 33 kD (unglycosylated) type I transmembrane protein with a single IgV domain contains two potential N-glycosylation sites, a serine/threonine-rich region with numerous predicted O-linked glycosylation sites, a single membrane-spanning region, and a short cytoplasmic tail. TLT2 is expressed on B lineage cells, macrophages, neutrophils in bone marrow and periphery, and the expression level can be upregulated in response to inflammation. As a receptor, TLT2 likely plays a role in innate immunity. Recent studies have demonstrated that ligation of TLT2 inhibits the oxidative burst in neutrophils upon fMLP stimulation, indicating that TLT2 may function as an inhibitory receptor that attenuates activation of neutrophils, and possibly macrophages. Recently TLT-2 protein has been found on CD8+ T cells and is induced on activated CD4+ T cells.
Reactivity
Human
Host
Mouse
Conjugate
Yellow dye
Isotype
IgG
Vial size
25 tests
Storage
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
TREML2 protein structure - 351203 shown in red.