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- Antigen structure
- References [20]
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- Product number
- 16370-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16370-1-AP, RRID:AB_2216716
- Product name
- WAPL; WAPAL antibody
- Antibody type
- Polyclonal
- Description
- WAPL; WAPAL antibody (Cat. #16370-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cohesin cofactor dosage sets the rate of loop extrusion, rendering genome folding tunable yet vulnerable to genetic disruption.
LncRNA FAM30A as a potential biomarker associated with periodontitis and its role in inflammatory responses and osteogenesis.
S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion.
Acute NIPBL depletion reveals in vivo dynamics of loop extrusion and its role in transcription activation.
MRE11 orchestrates porcine oocyte meiotic progression by modulating the spindle assembly checkpoint.
The mitotic STAG3-cohesin complex shapes male germline nucleome.
Mechanism for local attenuation of DNA replication at double-strand breaks.
Interplay between CTCF-binding and CTCF-lacking regulatory elements in generating an architectural stripe at the Igh locus.
CTCF/RAD21 organize the ground state of chromatin-nuclear speckle association.
Extrusion fountains are restricted by WAPL-dependent cohesin release and CTCF barriers.
BRWD1 orchestrates small pre-B cell chromatin topology by converting static to dynamic cohesin.
Context-dependent perturbations in chromatin folding and the transcriptome by cohesin and related factors.
Rearrangement of T Cell genome architecture regulates GVHD.
CTCF and cohesin promote focal detachment of DNA from the nuclear lamina.
RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis.
WAPL maintains a cohesin loading cycle to preserve cell-type-specific distal gene regulation.
WAPL orchestrates porcine oocyte meiotic progression via control of spindle assembly checkpoint activity.
Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse.
Esco1 Acetylates Cohesin via a Mechanism Different from That of Esco2.
Allogeneic T cell responses are regulated by a specific miRNA-mRNA network.
Shah R, Tortora MMC, Louafi N, Rahmaninejad H, Hansen KL, Anderson EC, Bonitto K, Wen D, Giorgetti L, Fudenberg G, Nora EP
Molecular cell 2026 May 7;86(9):1635-1652.e8
Molecular cell 2026 May 7;86(9):1635-1652.e8
LncRNA FAM30A as a potential biomarker associated with periodontitis and its role in inflammatory responses and osteogenesis.
Huo Y, Liu L, Fan C, Chen J, Gu H
BMC oral health 2026 Mar 13;26(1)
BMC oral health 2026 Mar 13;26(1)
S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion.
Jiang M, Zhang J, He J, Miao Y, Wang L, Zhong H, Gong Y, Li Z, Du LL, Xu X, Chen C, Ydyrys A, Xia Y, Cao Q, Lou H, Hou W
The EMBO journal 2026 Jan;45(1):278-309
The EMBO journal 2026 Jan;45(1):278-309
Acute NIPBL depletion reveals in vivo dynamics of loop extrusion and its role in transcription activation.
Popay TM, Pant A, Munting F, Tastemel M, Black ME, Haghani N, Dixon JR
Nature genetics 2026 Apr;58(4):869-880
Nature genetics 2026 Apr;58(4):869-880
MRE11 orchestrates porcine oocyte meiotic progression by modulating the spindle assembly checkpoint.
Zhang D, Yang Z, Zhang Y, Fang F, Cao H, Li Y, Cao Z, Xue Y, Zhang M
Frontiers in cell and developmental biology 2025;13:1635110
Frontiers in cell and developmental biology 2025;13:1635110
The mitotic STAG3-cohesin complex shapes male germline nucleome.
Nagano M, Hu B, Ogata K, Umemura F, Ishikura Y, Suzuki S, Katsifis CC, Yoshinaga M, Litos G, Nagasaka K, Tang W, Nosaka Y, Sasada H, Wang H, Kondo D, Katou Y, Mizuta K, Yabuta Y, Ohta H, de Luna Vitorino FN, Arima H, Ichikawa T, Gabriele M, Majewski J, Garcia BA, Takeuchi O, Yoshida S, Hansen AS, Peters JM, Ishihama Y, Saitou M
Nature structural & molecular biology 2025 Nov;32(11):2203-2218
Nature structural & molecular biology 2025 Nov;32(11):2203-2218
Mechanism for local attenuation of DNA replication at double-strand breaks.
Sebastian R, Sun EG, Fedkenheuer M, Fu H, Jung S, Thakur BL, Redon CE, Pegoraro G, Tran AD, Gross JM, Mosavarpour S, Kusi NA, Ray A, Dhall A, Pongor LS, Casellas R, Aladjem MI
Nature 2025 Mar;639(8056):1084-1092
Nature 2025 Mar;639(8056):1084-1092
Interplay between CTCF-binding and CTCF-lacking regulatory elements in generating an architectural stripe at the Igh locus.
Ma F, Ollikainen N, Du H, Braikia FZ, Cui N, Bianchi AH, Dunn C, Nguyen C, Fan J, De S, Sen R, Qiu X
Nature communications 2025 Mar 3;16(1):2148
Nature communications 2025 Mar 3;16(1):2148
CTCF/RAD21 organize the ground state of chromatin-nuclear speckle association.
Yu R, Roseman S, Siegenfeld AP, Gardner Z, Nguyen SC, Tran KA, Joyce EF, Jain R, Liau BB, Krantz ID, Alexander KA, Berger SL
Nature structural & molecular biology 2025 Jun;32(6):1069-1080
Nature structural & molecular biology 2025 Jun;32(6):1069-1080
Extrusion fountains are restricted by WAPL-dependent cohesin release and CTCF barriers.
Liu NQ, Magnitov M, Schijns MMGA, van Schaik T, Teunissen H, van Steensel B, de Wit E
Nucleic acids research 2025 Jun 20;53(12)
Nucleic acids research 2025 Jun 20;53(12)
BRWD1 orchestrates small pre-B cell chromatin topology by converting static to dynamic cohesin.
Mandal M, Maienschein-Cline M, Hu Y, Mohsin A, Veselits ML, Wright NE, Okoreeh MK, Yoon YM, Veselits J, Georgopoulos K, Clark MR
Nature immunology 2024 Jan;25(1):129-141
Nature immunology 2024 Jan;25(1):129-141
Context-dependent perturbations in chromatin folding and the transcriptome by cohesin and related factors.
Nakato R, Sakata T, Wang J, Nagai LAE, Nagaoka Y, Oba GM, Bando M, Shirahige K
Nature communications 2023 Sep 19;14(1):5647
Nature communications 2023 Sep 19;14(1):5647
Rearrangement of T Cell genome architecture regulates GVHD.
Sun Y, Dotson GA, Muir LA, Ronquist S, Oravecz-Wilson K, Peltier D, Seike K, Li L, Meixner W, Rajapakse I, Reddy P
iScience 2022 Sep 16;25(9):104846
iScience 2022 Sep 16;25(9):104846
CTCF and cohesin promote focal detachment of DNA from the nuclear lamina.
van Schaik T, Liu NQ, Manzo SG, Peric-Hupkes D, de Wit E, van Steensel B
Genome biology 2022 Sep 1;23(1):185
Genome biology 2022 Sep 1;23(1):185
RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis.
Zhang S, Übelmesser N, Josipovic N, Forte G, Slotman JA, Chiang M, Gothe HJ, Gusmao EG, Becker C, Altmüller J, Houtsmuller AB, Roukos V, Wendt KS, Marenduzzo D, Papantonis A
Science advances 2021 Oct 22;7(43):eabg8205
Science advances 2021 Oct 22;7(43):eabg8205
WAPL maintains a cohesin loading cycle to preserve cell-type-specific distal gene regulation.
Liu NQ, Maresca M, van den Brand T, Braccioli L, Schijns MMGA, Teunissen H, Bruneau BG, Nora EP, de Wit E
Nature genetics 2021 Jan;53(1):100-109
Nature genetics 2021 Jan;53(1):100-109
WAPL orchestrates porcine oocyte meiotic progression via control of spindle assembly checkpoint activity.
Zhou C, Miao Y, Zhang X, Xiong B
Reproductive biology and endocrinology : RB&E 2021 Apr 19;19(1):57
Reproductive biology and endocrinology : RB&E 2021 Apr 19;19(1):57
Cohesin Removal along the Chromosome Arms during the First Meiotic Division Depends on a NEK1-PP1γ-WAPL Axis in the Mouse.
Brieño-Enríquez MA, Moak SL, Toledo M, Filter JJ, Gray S, Barbero JL, Cohen PE, Holloway JK
Cell reports 2016 Oct 18;17(4):977-986
Cell reports 2016 Oct 18;17(4):977-986
Esco1 Acetylates Cohesin via a Mechanism Different from That of Esco2.
Minamino M, Ishibashi M, Nakato R, Akiyama K, Tanaka H, Kato Y, Negishi L, Hirota T, Sutani T, Bando M, Shirahige K
Current biology : CB 2015 Jun 29;25(13):1694-706
Current biology : CB 2015 Jun 29;25(13):1694-706
Allogeneic T cell responses are regulated by a specific miRNA-mRNA network.
Sun Y, Tawara I, Zhao M, Qin ZS, Toubai T, Mathewson N, Tamaki H, Nieves E, Chinnaiyan AM, Reddy P
The Journal of clinical investigation 2013 Nov;123(11):4739-54
The Journal of clinical investigation 2013 Nov;123(11):4739-54
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The WAPL; WAPAL antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human WAPL; WAPAL. This antibody recognizes human, mouse, rat antigen. The WAPL; WAPAL antibody has been validated for the following applications: ELISA, WB analysis.
