67221-1-Ig

antibody from Proteintech Group

Targeting: SLC31A1 COPT1, CTR1, hCTR1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

67221-1-Ig

Provider

Proteintech Group

Product name

SLC31A1 antibody

Antibody type

Monoclonal

Description

SLC31A1 antibody (Cat. #67221-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

1A4H5

Vial size

20ul, 150ul

References

Submitted references

Tannic Acid Achieves Rapid Scar-Free Corneal Healing by Chelating Excess Copper to Suppress Aberrant LOX-Mediated Fibrosis.

Cai M, Wang X, Sun S, Yuan Z, Wang Y, Hua X, Yuan X
Investigative ophthalmology & visual science 2026 Mar 2;67(3):13

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Decoding microglial metabolic cell death and PANoptosis hub genes in subacute phase of traumatic brain injury: a multi-omics and experimental validation study.

Wu Z, Yang BY, Lai JQ, Lin SH, Lin L, Chen JL, Pan JX, Ruan YX, Chen XR
Apoptosis : an international journal on programmed cell death 2026 Mar 19;31(3)

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COA6 deficiency inhibits hepatocellular carcinoma progression by regulating cuproptosis through the JAK/STAT signaling pathway.

Tian K, Yang Y, Niu X, Wei X, Zhang M, Zhou Y, Yang M, Sun H, Zhu L, Liu F
Biochimica et biophysica acta. Molecular cell research 2026 Jan;1873(1):120065

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Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia.

Lewis AC, Gruber E, Franich R, Armstrong J, Kelly MJ, Opazo CM, Low YC, Flippe L, Wijanarko K, Rowe CL, Mawal CH, Birrell A, So J, Vaidyanathan S, Ting K, Semcesen LN, Last K, Ang CS, Pomilio G, Brown FC, Wei AH, Powell JA, Ng ES, Frazier AE, McArthur K, Lalaoui N, Stroud DA, Brown KK, Johnstone RW, Kats LM
Cell 2026 Jan 8;189(1):215-232.e24

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Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasis.

Lane AR, Gonzalez N, Gokhale A, Zlatic SA, Allen BM, Scher NE, Roberts AM, Duong DM, Roberts BR, Vrailas-Mortimer AD, Werner E, Faundez V
bioRxiv : the preprint server for biology 2026 Jan 14;

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Plasma IgG and IgM autoantibodies to COPT1 as potential biomarkers for detection of non-small cell lung cancer.

Cao X, Li J, Liu S, Liu A, Zhang L, Chen F, Li Y, Ma H, Sun W, Ouyang S, Dai L, Liu J
Frontiers in immunology 2025;16:1455095

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RAD23B acquires a copper metalloadaptor function in amphibian-to-reptile evolution to increase metabolism and regulate genomic integrity.

Xiao T, He D, Liu D, Jia S, Chen Q, Silverman D, Maitra N, Huang AY, Pezacki A, Nguyen TT, Rao G, Tillage R, Deng K, Weinshenker D, Britt RD, Kelly MJS, Dan Y, Chang CJ
Molecular cell 2025 Sep 18;85(18):3443-3459.e11

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Copper's new role in cancer: how cuproptosis-related genes could revolutionize glioma treatment.

Wang Y, Qiao S, Wang P, Li M, Ma X, Wang H, Dong J
BMC cancer 2025 May 12;25(1):859

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SLC31A1 promotes chemoresistance through inducing CPT1A-mediated fatty acid oxidation in ER-positive breast cancer.

Li X, Ge J, Wan M, Feng T, Li X, Zhang H, Wang Z, Gao Y, Chen M, Pan F
Neoplasia (New York, N.Y.) 2025 Mar;61:101125

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Edaravone dextranol alleviates ferroptosis, Cuproptosis, and blood-brain barrier damage after acute cerebral infarction.

Jin G, Han W, Duan T, Xue Z, Song C, Xu Y, Yu M
Metabolic brain disease 2025 Mar 3;40(3):134

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Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.

Lane AR, Scher NE, Bhattacharjee S, Zlatic SA, Roberts AM, Gokhale A, Singleton KS, Duong DM, McKenna M, Liu WL, Baiju A, Moctezuma FGR, Tran T, Patel AA, Clayton LB, Petris MJ, Wood LB, Patgiri A, Vrailas-Mortimer AD, Cox DN, Roberts BR, Werner E, Faundez V
Molecular biology of the cell 2025 Mar 1;36(3):ar33

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Copper oxide nanoparticles induce pulmonary inflammation via triggering cellular cuproptosis.

Zhang X, Peng Z, Wang Q, Zhang W, Bu Q, Sun D
Toxicology 2025 Jun;514:154131

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Modulation of copper homeostasis and cuproptosis by PDHA1 in acute myeloid leukemia.

Chen T, Wei N, Lv W, Qu L, Qu Q, Wu C, Ling Y, Liu H, Liu H
Discover oncology 2025 Jun 10;16(1):1044

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Exploiting mitochondrial dysfunction to overcome BRAF inhibitor resistance in advanced melanoma: the role of disulfiram as a copper ionophore.

Zhao B, Ban F, Li Y, Shi Q, Guo S, Yi X, Wang H, Gao T, Li C, Zhu G
Cell death & disease 2025 Jul 1;16(1):482

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An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière's disease.

Harhai M, Foged MM, Zarges C, Landoni JC, Chollet S, Simonelli M, Recazens E, Lisci M, Laban N, Manley S, Riemer J, Lopez-Escamez JA, Lysakowski A, Jourdain AA
Cell reports 2025 Aug 26;44(8):116069

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Copper-overload promotes ferroptosis in cervical cancer cells by upregulating HMOX1 expression.

Zhao C, Wang T, Lu Y, Zhou Y, Chen J, Ju R
Discover oncology 2025 Aug 14;16(1):1549

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Identification of Cuproptosis-Related Genes for Molecular Subtyping: Predicting Prognostic and Therapeutic Response in Glioma.

Xia X, Huang X, Wu L, Xu P, Li P
OncoTargets and therapy 2024;17:1069-1088

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Zinc transporter 1 functions in copper uptake and cuproptosis.

Li Y, Ma J, Wang R, Luo Y, Zheng S, Wang X
Cell metabolism 2024 Sep 3;36(9):2118-2129.e6

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Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.

Lane AR, Scher NE, Bhattacharjee S, Zlatic SA, Roberts AM, Gokhale A, Singleton KS, Duong DM, McKenna M, Liu WL, Baiju A, Moctezuma FGR, Tran T, Patel AA, Clayton LB, Petris MJ, Wood LB, Patgiri A, Vrailas-Mortimer AD, Cox DN, Roberts BR, Werner E, Faundez V
bioRxiv : the preprint server for biology 2024 Nov 18;

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Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma.

Yang F, Jia L, Zhou HC, Huang JN, Hou MY, Liu FT, Prabhu N, Li ZJ, Yang CB, Zou C, Nordlund P, Wang JG, Dai LY
Acta pharmacologica Sinica 2024 Feb;45(2):391-404

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Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers.

Liu C, Chen L, Cong Y, Cheng L, Shuai Y, Lv F, Chen K, Song Y, Xing Y
Cell death & disease 2024 Feb 16;15(2):149

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Changes in cuproptosis-related gene expression in periodontitis: An integrated bioinformatic analysis.

Liu N, He Y, Chen X, Qiu G, Wu Y, Shen Y
Life sciences 2024 Feb 1;338:122388

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Analysis of cuproptosis-related genes in prognosis and immune infiltration in grade 4 diffuse gliomas.

Liu H, Bao X, Zeng Z, Liu W, Li M
Heliyon 2024 Apr 15;10(7):e29212

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Identification of hub cuproptosis related genes and immune cell infiltration characteristics in periodontitis.

Liu S, Ge J, Chu Y, Cai S, Wu J, Gong A, Zhang J
Frontiers in immunology 2023;14:1164667

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Significance of cuproptosis- related genes in the diagnosis and classification of psoriasis.

Lin Q, Zhu J, Chen J, Jia S, Nie S
Frontiers in molecular biosciences 2023;10:1115091

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A co-opted endogenous retroviral envelope promotes cell survival by controlling CTR1-mediated copper transport and homeostasis.

Tury S, Chauveau L, Lecante A, Courgnaud V, Battini JL
Cell reports 2023 Sep 26;42(9):113065

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Integrated bioinformatics and experiment revealed that cuproptosis is the potential common pathogenesis of three kinds of primary cardiomyopathy.

Wang M, Xu X, Li J, Gao Z, Ding Y, Chen X, Xiang Q, Shen L
Aging 2023 Dec 11;15(23):14210-14241

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Identification of Copper Transporter 1 as a Receptor for Feline Endogenous Retrovirus ERV-DC14.

Tury S, Giovannini D, Ivanova S, Touhami J, Courgnaud V, Battini JL
Journal of virology 2022 Jun 22;96(12):e0022922