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- Antibody Data
- Antigen structure
- References [7]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11499-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11499-1-AP, RRID:AB_2102740
- Product name
- FBXW2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated FBXW2 antibody (Cat. #11499-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references FBXO43 promotes cell cycle progression in cancer cells through stabilizing SKP2.
FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis.
FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation.
TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes to Sorafenib Resistance.
USP2 is an SKP2 deubiquitylase that stabilizes both SKP2 and its substrates.
FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation.
The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor.
Zheng L, Shen J, Chen Y, Lin J, Li P, Zhao X, Ren H, Sun Y, Wang Z
Cancer letters 2024 Jun 1;591:216848
Cancer letters 2024 Jun 1;591:216848
FBXW2 suppresses breast tumorigenesis by targeting AKT-Moesin-SKP2 axis.
Barik GK, Sahay O, Mukhopadhyay A, Manne RK, Islam S, Roy A, Nath S, Santra MK
Cell death & disease 2023 Sep 22;14(9):623
Cell death & disease 2023 Sep 22;14(9):623
FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation.
Zhou T, Chen T, Lai B, Zhang W, Luo X, Xia D, Fu W, Xu J
Cellular and molecular life sciences : CMLS 2022 May 2;79(5):268
Cellular and molecular life sciences : CMLS 2022 May 2;79(5):268
TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes to Sorafenib Resistance.
Xia S, Ji L, Tao L, Pan Y, Lin Z, Wan Z, Pan H, Zhao J, Cai L, Xu J, Cai X
Cellular and molecular gastroenterology and hepatology 2021;12(3):1121-1143
Cellular and molecular gastroenterology and hepatology 2021;12(3):1121-1143
USP2 is an SKP2 deubiquitylase that stabilizes both SKP2 and its substrates.
Zhang F, Zhao Y, Sun Y
The Journal of biological chemistry 2021 Oct;297(4):101109
The Journal of biological chemistry 2021 Oct;297(4):101109
FBXW2 suppresses migration and invasion of lung cancer cells via promoting β-catenin ubiquitylation and degradation.
Yang F, Xu J, Li H, Tan M, Xiong X, Sun Y
Nature communications 2019 Mar 27;10(1):1382
Nature communications 2019 Mar 27;10(1):1382
The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor.
Xu J, Zhou W, Yang F, Chen G, Li H, Zhao Y, Liu P, Li H, Tan M, Xiong X, Sun Y
Nature communications 2017 Jan 16;8:14002
Nature communications 2017 Jan 16;8:14002
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse testis tissue were subjected to SDS PAGE followed by western blot with 11499-1-AP(FBXW2 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FBXW2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FBXW2. This antibody recognizes human, mouse, rat antigen. The FBXW2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
