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- Antigen structure
- References [16]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- 25244-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- PHLPPL antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PHLPPL antibody (Cat. #25244-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Hyperoxia-Induced miR-195 Causes Bronchopulmonary Dysplasia in Neonatal Mice.
Trim46 knockout impaired neuronal architecture and caused hypoactive behavior in rats.
The lack of homology domain and leucine rich repeat protein phosphatase 2 ameliorates visual impairment in rats with diabetic retinopathy through regulation of the AKT-GSK-3β-Nrf2 signal cascade.
CXADR promote epithelial-mesenchymal transition in endometriosis by modulating AKT/GSK-3β signaling.
Loss of pleckstrin homology domain and leucine-rich repeat protein phosphatase 2 has protective effects on high glucose-injured retinal ganglion cells via the effect on the Akt-GSK-3β-Nrf2 pathway.
Circular RNA circRASSF5 Functions as an Anti-Oncogenic Factor in Hepatocellular Carcinoma by Acting as a Competitive Endogenous RNA Through Sponging miR-331-3p.
Colonic Epithelial PHLPP2 Deficiency Promotes Colonic Epithelial Pyroptosis by Activating the NF-κB Signaling Pathway.
Reduced PHLPP Expression Leads to EGFR-TKI Resistance in Lung Cancer by Activating PI3K-AKT and MAPK-ERK Dual Signaling.
Role of epigenetic m(6) A RNA methylation in vascular development: mettl3 regulates vascular development through PHLPP2/mTOR-AKT signaling.
Tumor-Derived EV-Encapsulated miR-181b-5p Induces Angiogenesis to Foster Tumorigenesis and Metastasis of ESCC.
LncRNA MBNL1-AS1 represses cell proliferation and enhances cell apoptosis via targeting miR-135a-5p/PHLPP2/FOXO1 axis in bladder cancer.
miR-762 Promotes Malignant Development of Head and Neck Squamous Cell Carcinoma by Targeting PHLPP2 and FOXO4.
PHLPP2 as a novel metastatic and prognostic biomarker in non-small cell lung cancer patients.
PHLPP regulates hexokinase 2-dependent glucose metabolism in colon cancer cells.
High PHLPP1 expression levels predicts longer time of acquired resistance to EGFR tyrosine kinase inhibitors in patients with lung adenocarcinoma.
PHLPP negatively regulates cell motility through inhibition of Akt activity and integrin expression in pancreatic cancer cells.
Philpot P, Graumuller F, Melchiorre N, Prahaladan V, Takada X, Chandran S, Guillermo M, Dickler D, Aghai ZH, Das P, Bhandari V
Biomedicines 2024 May 29;12(6)
Biomedicines 2024 May 29;12(6)
Trim46 knockout impaired neuronal architecture and caused hypoactive behavior in rats.
Guan F, Gao S, Sheng H, Ma Y, Chen W, Qi X, Zhang X, Gao X, Pang S, Zhang L, Zhang L
Developmental dynamics : an official publication of the American Association of Anatomists 2024 Jul;253(7):659-676
Developmental dynamics : an official publication of the American Association of Anatomists 2024 Jul;253(7):659-676
The lack of homology domain and leucine rich repeat protein phosphatase 2 ameliorates visual impairment in rats with diabetic retinopathy through regulation of the AKT-GSK-3β-Nrf2 signal cascade.
Chen L, Qi E, Liu X, Cui L, Fan X, Wei T, Hu Y
Toxicology and applied pharmacology 2024 Jan;482:116766
Toxicology and applied pharmacology 2024 Jan;482:116766
CXADR promote epithelial-mesenchymal transition in endometriosis by modulating AKT/GSK-3β signaling.
Tan HJ, Deng ZH, Zhang C, Deng HW, Xiao HM
Cell cycle (Georgetown, Tex.) 2023 Nov;22(21-22):2436-2448
Cell cycle (Georgetown, Tex.) 2023 Nov;22(21-22):2436-2448
Loss of pleckstrin homology domain and leucine-rich repeat protein phosphatase 2 has protective effects on high glucose-injured retinal ganglion cells via the effect on the Akt-GSK-3β-Nrf2 pathway.
Liu X, Liu Y, Chen L, Zhang Z, Cui L, Wei T
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Mar;72(3):373-385
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Mar;72(3):373-385
Circular RNA circRASSF5 Functions as an Anti-Oncogenic Factor in Hepatocellular Carcinoma by Acting as a Competitive Endogenous RNA Through Sponging miR-331-3p.
Zhou Z, Cui X, Gao P, Zhang X, Zhu C, Sun B
Journal of hepatocellular carcinoma 2022;9:1041-1056
Journal of hepatocellular carcinoma 2022;9:1041-1056
Colonic Epithelial PHLPP2 Deficiency Promotes Colonic Epithelial Pyroptosis by Activating the NF-κB Signaling Pathway.
Li DF, Chang X, Zhao JL, Chen XM, Xu ZL, Zhang DG, Wu BH, Wang LS, Bai Y, Yao J
Oxidative medicine and cellular longevity 2021;2021:5570731
Oxidative medicine and cellular longevity 2021;2021:5570731
Reduced PHLPP Expression Leads to EGFR-TKI Resistance in Lung Cancer by Activating PI3K-AKT and MAPK-ERK Dual Signaling.
Wang W, Xia X, Chen K, Chen M, Meng Y, Lv D, Yang H
Frontiers in oncology 2021;11:665045
Frontiers in oncology 2021;11:665045
Role of epigenetic m(6) A RNA methylation in vascular development: mettl3 regulates vascular development through PHLPP2/mTOR-AKT signaling.
Parial R, Li H, Li J, Archacki S, Yang Z, Wang IZ, Chen Q, Xu C, Wang QK
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21465
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21465
Tumor-Derived EV-Encapsulated miR-181b-5p Induces Angiogenesis to Foster Tumorigenesis and Metastasis of ESCC.
Wang Y, Lu J, Chen L, Bian H, Hu J, Li D, Xia C, Xu H
Molecular therapy. Nucleic acids 2020 Jun 5;20:421-437
Molecular therapy. Nucleic acids 2020 Jun 5;20:421-437
LncRNA MBNL1-AS1 represses cell proliferation and enhances cell apoptosis via targeting miR-135a-5p/PHLPP2/FOXO1 axis in bladder cancer.
Wei X, Yang X, Wang B, Yang Y, Fang Z, Yi C, Shi L, Song D
Cancer medicine 2020 Jan;9(2):724-736
Cancer medicine 2020 Jan;9(2):724-736
miR-762 Promotes Malignant Development of Head and Neck Squamous Cell Carcinoma by Targeting PHLPP2 and FOXO4.
Chen S, Zhang JY, Sun LS, Li XF, Bai JY, Zhang HY, Li TJ
OncoTargets and therapy 2019;12:11425-11436
OncoTargets and therapy 2019;12:11425-11436
PHLPP2 as a novel metastatic and prognostic biomarker in non-small cell lung cancer patients.
Wang H, Gu R, Tian F, Liu Y, Fan W, Xue G, Cai L, Xing Y
Thoracic cancer 2019 Nov;10(11):2124-2132
Thoracic cancer 2019 Nov;10(11):2124-2132
PHLPP regulates hexokinase 2-dependent glucose metabolism in colon cancer cells.
Xiong X, Wen YA, Mitov MI, C Oaks M, Miyamoto S, Gao T
Cell death discovery 2017;3:16103
Cell death discovery 2017;3:16103
High PHLPP1 expression levels predicts longer time of acquired resistance to EGFR tyrosine kinase inhibitors in patients with lung adenocarcinoma.
Xie Y, Lv D, Wang W, Ye M, Chen X, Yang H
Oncotarget 2017 Aug 29;8(35):59000-59007
Oncotarget 2017 Aug 29;8(35):59000-59007
PHLPP negatively regulates cell motility through inhibition of Akt activity and integrin expression in pancreatic cancer cells.
Smith AJ, Wen YA, Stevens PD, Liu J, Wang C, Gao T
Oncotarget 2016 Feb 16;7(7):7801-15
Oncotarget 2016 Feb 16;7(7):7801-15
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 25244-1-AP( PHLPPL Antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PHLPPL antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human PHLPPL. This antibody recognizes human, mouse, rat antigen. The PHLPPL antibody has been validated for the following applications: ELISA, WB, IF, IHC analysis.
