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- Antibody Data
- Antigen structure
- References [4]
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- Western blot [1]
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- Product number
- ABIN1449986 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2) (C-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- PHLPP2 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human PHLPP2.
- Description
- Affinity chromatography purified via peptide column
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- C-Term
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 1.0 mg/mL
- Storage
- Store the antibody (in aliquots) at -20°C.
- Handling
- Avoid repeated freezing and thawing.
Submitted references Activation of PH-domain leucine-rich protein phosphatase 2 (PHLPP2) by agonist stimulation in cardiac myocytes expressing adenylyl cyclase type 6.
PHLiPPing the switch on Akt and protein kinase C signaling.
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.
Gao MH, Miyanohara A, Feramisco JR, Tang T
Biochemical and biophysical research communications 2009 Jun 26;384(2):193-8
Biochemical and biophysical research communications 2009 Jun 26;384(2):193-8
PHLiPPing the switch on Akt and protein kinase C signaling.
Brognard J, Newton AC
Trends in endocrinology and metabolism: TEM 2008 Aug;19(6):223-30
Trends in endocrinology and metabolism: TEM 2008 Aug;19(6):223-30
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.
Brognard J, Sierecki E, Gao T, Newton AC
Molecular cell 2007 Mar 23;25(6):917-31
Molecular cell 2007 Mar 23;25(6):917-31
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.
Gao T, Furnari F, Newton AC
Molecular cell 2005 Apr 1;18(1):13-24
Molecular cell 2005 Apr 1;18(1):13-24
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Supportive validation
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- antibodies-online (provider)
- Main image
- Experimental details
- Western blot analysis of PHLPP2 in SW480 cell lysate with PHLPP2 antibody Cat.-No AP55482PU-N at 1 ?g/ml in (A) the presence and (B) the absence of blocking peptide.
