14412-1-AP

antibody from Proteintech Group

Targeting: PEG10 HB-1, KIAA1051, Mar2, Mart2, MEF3L, RGAG3, RTL2, SIRH1

Provider product page for 14412-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [14]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 14412-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14412-1-AP, RRID:AB_10694427
Product name: PEG10 antibody
Antibody type: Polyclonal
Description: PEG10 antibody (Cat. #14412-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PEG10 protein structure - 14412-1-AP shown in red.

Submitted references Interactome screening implicates BAG6 as a suppressor of UBQLN2 misfolding in ALS/FTD.

Kim SH, Boos CE, Scalf M, Wilkemeyer AK, Smith LM, Tibbetts RS
Frontiers in molecular neuroscience 2025;18:1720347

Interactome screening implicates BAG6 as a suppressor of UBQLN2 misfolding in ALS-dementia.

Kim SH, Boos CE, Scalf M, Wilkemeyer AK, Smith LM, Tibbetts RS
bioRxiv : the preprint server for biology 2025 Oct 15;

Evolutionary dynamics of PEG10 and its interacting proteins during early and late-stage placental development in ruminants.

Liu Y, Yu W, Tang J, Zhang Y, Yang J, Wu Q, Li H, Zhu Z, Li A, Han J, Zhang X, Luo Y, Zhang Y, Liu J
International journal of biological macromolecules 2025 May;309(Pt 2):142761

Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and shape their functional biology.

Mohan HM, Fernandez MG, Huang C, Lin R, Ryou JH, Seyfried D, Grotewold N, Barget AJ, Whiteley AM, Basrur V, Mosalaganti S, Paulson HL, Sharkey LM
Science advances 2025 Jul 18;11(29):eadu6354

NAP1L5 promotes epithelial-mesenchymal transition by regulating PEG10 expression in acute myeloid leukaemia.

Wu H, Luo H, Wang M, Du Y, Li J
Leukemia research 2025 Jan;148:107623

UBQLN2 is necessary for UBE3A-mediated proteasomal degradation of the domesticated retroelement PEG10.

Roberts JE, Huynh PT, Carale LO, Whiteley AM
Journal of cell science 2025 Dec 15;138(24)

The gag-like gene RTL8 antagonizes PEG10-mediated virus like particles.

Campodonico W, Mohan HM, Huynh PT, Black HH, Lau CI, Paulson HL, Sharkey LM, Whiteley AM
PloS one 2024;19(12):e0310946

Endogenous retrovirus-like proteins recruit UBQLN2 to stress granules and alter their functional properties.

Mohan HM, Fernandez MG, Huang C, Lin R, Ryou JH, Seyfried D, Grotewold N, Whiteley AM, Barmada SJ, Basrur V, Mosalaganti S, Paulson HL, Sharkey LM
bioRxiv : the preprint server for biology 2024 Oct 25;

Disruption of maternal vascular remodeling by a fetal endoretrovirus-derived gene in preeclampsia.

Gong X, He W, Jin W, Ma H, Wang G, Li J, Xiao Y, Zhao Y, Chen Q, Guo H, Yang J, Qi Y, Dong W, Fu M, Li X, Liu J, Liu X, Yin A, Zhang Y, Wei Y
Genome biology 2024 May 7;25(1):117

A 12-gene panel in estimating hormone-treatment responses of castration-resistant prostate cancer patients generated using a combined analysis of bulk and single-cell sequencing data.

Huang J, Liu D, Li J, Xu J, Dong S, Zhang H
Annals of medicine 2023;55(2):2260387

Targeting PEG10 as a novel therapeutic approach to overcome CDK4/6 inhibitor resistance in breast cancer.

Katuwal NB, Kang MS, Ghosh M, Hong SD, Jeong YG, Park SM, Kim SG, Sohn J, Kim TH, Moon YW
Journal of experimental & clinical cancer research : CR 2023 Nov 28;42(1):325

UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS.

Black HH, Hanson JL, Roberts JE, Leslie SN, Campodonico W, Ebmeier CC, Holling GA, Tay JW, Matthews AM, Ung E, Lau CI, Whiteley AM
eLife 2023 Mar 23;12

Cellular architecture of human brain metastases.

Gonzalez H, Mei W, Robles I, Hagerling C, Allen BM, Hauge Okholm TL, Nanjaraj A, Verbeek T, Kalavacherla S, van Gogh M, Georgiou S, Daras M, Phillips JJ, Spitzer MH, Roose JP, Werb Z
Cell 2022 Feb 17;185(4):729-745.e20

Transcriptional regulator CTR9 promotes hepatocellular carcinoma progression and metastasis via increasing PEG10 transcriptional activity.

Zhang B, Liu ZY, Wu R, Zhang CM, Cao K, Shan WG, Liu Z, Ji M, Tian ZL, Sethi G, Shi HL, Wang RH
Acta pharmacologica Sinica 2022 Aug;43(8):2109-2118

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: MCF7 cells were subjected to SDS PAGE followed by western blot with 14412-1-AP(PEG10 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using PEG10 antibody 14412-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 14412-1-AP(PEG10 antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 14412-1-AP(PEG10 antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue