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- Antibody Data
- Antigen structure
- References [16]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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- Product number
- 18160-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18160-1-AP, RRID:AB_2073200
- Product name
- TEM1 antibody
- Antibody type
- Polyclonal
- Description
- TEM1 antibody (Cat. #18160-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Deciphering the Dysregulating IGF-1-SP1-CD248 Pathway in Fibroblast Functionality during Diabetic Wound Healing.
Expression of tumor endothelial marker 1 in cardiac fibroblast contributes to atrial fibrosis in atrial fibrillation.
Regulation of matrix reloading by tumor endothelial marker 1 protects against abdominal aortic aneurysm.
Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer.
TEM1/endosialin/CD248 promotes pathologic scarring and TGF-β activity through its receptor stability in dermal fibroblasts.
Fibroblast expression of CD248 may contribute to exacerbation of microvascular damage during systemic sclerosis.
Defective Human SRP Induces Protein Quality Control and Triggers Stress Response.
Interference in melanoma CD248 function reduces vascular mimicry and metastasis.
Antibody-drug conjugates targeting CD248 inhibits liver fibrosis through specific killing on myofibroblasts.
CD248 as a novel therapeutic target in pulmonary arterial hypertension.
Interaction with CD68 and Regulation of GAS6 Expression by Endosialin in Fibroblasts Drives Recruitment and Polarization of Macrophages in Hepatocellular Carcinoma.
Tumor Endothelial Marker 1 (TEM1/Endosialin/CD248) Enhances Wound Healing by Interacting with Platelet-Derived Growth Factor Receptors.
Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation.
Generation of a novel Antibody-Drug Conjugate targeting endosialin: potent and durable antitumor response in sarcoma.
TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
Identification of a candidate proteomic signature to discriminate multipotent and non-multipotent stromal cells.
Ku YC, Lee YC, Hong YK, Lo YL, Kuo CH, Wang KC, Hsu CK, Yu CH, Lin SW, Wu HL
The Journal of investigative dermatology 2025 May;145(5):1180-1195
The Journal of investigative dermatology 2025 May;145(5):1180-1195
Expression of tumor endothelial marker 1 in cardiac fibroblast contributes to atrial fibrosis in atrial fibrillation.
Li YH, Hu YN, Huang TC, Huang MS, Chung HC
Scientific reports 2025 Mar 13;15(1):8685
Scientific reports 2025 Mar 13;15(1):8685
Regulation of matrix reloading by tumor endothelial marker 1 protects against abdominal aortic aneurysm.
Hong YK, Cheng TL, Hsu CK, Lee FT, Chang BI, Wang KC, Chang LY, Wu HL, Lai CH
International journal of biological sciences 2024;20(10):3691-3709
International journal of biological sciences 2024;20(10):3691-3709
Cancer-associated fibroblast phenotypes are associated with patient outcome in non-small cell lung cancer.
Cords L, Engler S, Haberecker M, Rüschoff JH, Moch H, de Souza N, Bodenmiller B
Cancer cell 2024 Mar 11;42(3):396-412.e5
Cancer cell 2024 Mar 11;42(3):396-412.e5
TEM1/endosialin/CD248 promotes pathologic scarring and TGF-β activity through its receptor stability in dermal fibroblasts.
Hong YK, Lin YC, Cheng TL, Lai CH, Chang YH, Huang YL, Hung CY, Wu CH, Hung KS, Ku YC, Ho YT, Tang MJ, Lin SW, Shi GY, McGrath JA, Wu HL, Hsu CK
Journal of biomedical science 2024 Jan 23;31(1):12
Journal of biomedical science 2024 Jan 23;31(1):12
Fibroblast expression of CD248 may contribute to exacerbation of microvascular damage during systemic sclerosis.
Cipriani P, Ruscitti P, Di Cola I, Vomero M, Abbruzzese F, Di Nino E, Ross R, Del Galdo F, Giacomelli R
Rheumatology (Oxford, England) 2023 Mar 1;62(3):1317-1325
Rheumatology (Oxford, England) 2023 Mar 1;62(3):1317-1325
Defective Human SRP Induces Protein Quality Control and Triggers Stress Response.
Tikhonova EB, Gutierrez Guarnizo SA, Kellogg MK, Karamyshev A, Dozmorov IM, Karamysheva ZN, Karamyshev AL
Journal of molecular biology 2022 Nov 30;434(22):167832
Journal of molecular biology 2022 Nov 30;434(22):167832
Interference in melanoma CD248 function reduces vascular mimicry and metastasis.
Kuo CH, Wu YF, Chang BI, Hsu CK, Lai CH, Wu HL
Journal of biomedical science 2022 Nov 18;29(1):98
Journal of biomedical science 2022 Nov 18;29(1):98
Antibody-drug conjugates targeting CD248 inhibits liver fibrosis through specific killing on myofibroblasts.
Liu S, Han D, Xu C, Yang F, Li Y, Zhang K, Zhao X, Zhang J, Lu T, Lu S, Shi C, Zhang R, Yang AG, Zhao A, Qin W, Yang B, Wen W
Molecular medicine (Cambridge, Mass.) 2022 Mar 22;28(1):37
Molecular medicine (Cambridge, Mass.) 2022 Mar 22;28(1):37
CD248 as a novel therapeutic target in pulmonary arterial hypertension.
Xu T, Shao L, Wang A, Liang R, Lin Y, Wang G, Zhao Y, Hu J, Liu S
Clinical and translational medicine 2020 Sep;10(5):e175
Clinical and translational medicine 2020 Sep;10(5):e175
Interaction with CD68 and Regulation of GAS6 Expression by Endosialin in Fibroblasts Drives Recruitment and Polarization of Macrophages in Hepatocellular Carcinoma.
Yang F, Wei Y, Han D, Li Y, Shi S, Jiao D, Wu J, Zhang Q, Shi C, Yang L, Song W, Zhang J, Han Y, Zhang R, Yang AG, Dimitrov DS, Zhao A, Qin W, Wen W
Cancer research 2020 Sep 15;80(18):3892-3905
Cancer research 2020 Sep 15;80(18):3892-3905
Tumor Endothelial Marker 1 (TEM1/Endosialin/CD248) Enhances Wound Healing by Interacting with Platelet-Derived Growth Factor Receptors.
Hong YK, Lee YC, Cheng TL, Lai CH, Hsu CK, Kuo CH, Hsu YY, Li JT, Chang BI, Ma CY, Lin SW, Wang KC, Shi GY, Wu HL
The Journal of investigative dermatology 2019 Oct;139(10):2204-2214.e7
The Journal of investigative dermatology 2019 Oct;139(10):2204-2214.e7
Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation.
Petrus P, Fernandez TL, Kwon MM, Huang JL, Lei V, Safikhan NS, Karunakaran S, O'Shannessy DJ, Zheng X, Catrina SB, Albone E, Laine J, Virtanen K, Clee SM, Kieffer TJ, Noll C, Carpentier AC, Johnson JD, Rydén M, Conway EM
EBioMedicine 2019 Jun;44:489-501
EBioMedicine 2019 Jun;44:489-501
Generation of a novel Antibody-Drug Conjugate targeting endosialin: potent and durable antitumor response in sarcoma.
Capone E, Piccolo E, Fichera I, Ciufici P, Barcaroli D, Sala A, De Laurenzi V, Iacobelli V, Iacobelli S, Sala G
Oncotarget 2017 Sep 1;8(36):60368-60377
Oncotarget 2017 Sep 1;8(36):60368-60377
TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
Suresh Babu S, Valdez Y, Xu A, O'Byrne AM, Calvo F, Lei V, Conway EM
BMC cancer 2014 Feb 20;14:113
BMC cancer 2014 Feb 20;14:113
Identification of a candidate proteomic signature to discriminate multipotent and non-multipotent stromal cells.
Rosu-Myles M, She YM, Fair J, Muradia G, Mehic J, Menendez P, Prasad SS, Cyr TD
PloS one 2012;7(6):e38954
PloS one 2012;7(6):e38954
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 18160-1-AP(CD248 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 18160-1-AP(CD248 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung cancer using 18160-1-AP(CD248 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TEM1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TEM1. This antibody recognizes human,mouse,rat antigen. The TEM1 antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.
