NTN4

This gene encodes a member of the netrin family of proteins, which function in various biological processes including axon guidance, tumorogenesis, and angiogenesis. Netrins are laminin-related proteins that have an N-terminal laminin-type domain, epidermal growth factor-like repeat domain, and a positively charged heparin-binding domain at the C-terminus. The protein encoded by this gene is involved in processes including neurite growth and migration, angiogenesis and mural cell adhesion to endothelial cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]

Description

Netrin 4

Tissue specificity

Tissue enhanced (lymphoid tissue)

Predicted location

Intracellular, Secreted to extracellular matrix

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (95657807 - 95791189)

Ensembl ID

ENSG00000074527  (ver. 103.38)

Orthologs

Mouse Ntn4: ENSMUSG00000020019

UniProt

Q9HB63

neXtProt

NX_Q9HB63

Human splice variants
Mouse splice variants

Protein structure