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- References [20]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 15543-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15543-1-AP, RRID:AB_2297856
- Product name
- MRPL11 antibody
- Antibody type
- Polyclonal
- Description
- MRPL11 antibody (Cat. #15543-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Suppressive Genetic Interactions Between Haploinsufficient Mitochondrial Genes Encoded in the 22q11.2 Microdeletion Locus Define Brain and Cardiac Phenotypes.
Intrinsic errors in mitochondrial translation trigger a decline in cell fitness.
Evaluating the feasibility of gene replacement strategies to treat MTRFR deficiency.
UBASH3B-mediated MRPL12 Y60 dephosphorylation inhibits LUAD development by driving mitochondrial metabolism reprogramming.
A roadmap for ribosome assembly in human mitochondria.
Sucrose Gradient Analysis of Human Mitochondrial Ribosomes and RNA.
Autoregulatory control of mitochondrial glutathione homeostasis.
GTPBP8 is required for mitoribosomal biogenesis and mitochondrial translation.
MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells.
Mitochondrial RNA methyltransferase TRMT61B is a new, potential biomarker and therapeutic target for highly aneuploid cancers.
Cultured lymphocytes' mitochondrial genome integrity is not altered by cladribine.
Nonstop mRNAs generate a ground state of mitochondrial gene expression noise.
Translation of MT-ATP6 pathogenic variants reveals distinct regulatory consequences from the co-translational quality control of mitochondrial protein synthesis.
Mitochondrial stress response triggered by defects in protein synthesis quality control.
A variant in MRPS14 (uS14m) causes perinatal hypertrophic cardiomyopathy with neonatal lactic acidosis, growth retardation, dysmorphic features and neurological involvement.
RNA modification landscape of the human mitochondrial tRNA(Lys) regulates protein synthesis.
Adult-onset obesity is triggered by impaired mitochondrial gene expression.
Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome.
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness.
Wynne M, Zlatic SA, Park AS, Crocker A, Mendez-Vazquez H, Liporace E, Gokhale A, Tower-Gilchrist C, Robinette M, Purcell RH, Bassell GJ, Werner E, Kwong JQ, Faundez V
bioRxiv : the preprint server for biology 2026 Jan 9;
bioRxiv : the preprint server for biology 2026 Jan 9;
Intrinsic errors in mitochondrial translation trigger a decline in cell fitness.
Bal GL, Ng KY, Berzell E, Akpinar A, Ekvik AE, Koludarova L, Naddafi S, Raths C, Vane-Tempest T, VanPortfliet JJ, O'Keefe S, Najumudeen AK, Nyman TA, Stewart JB, West AP, Battersby BJ
bioRxiv : the preprint server for biology 2025 Oct 15;
bioRxiv : the preprint server for biology 2025 Oct 15;
Evaluating the feasibility of gene replacement strategies to treat MTRFR deficiency.
Pratt SL, Zarate-Mendez M, Koludarova L, Jansson S, Airavaara M, Hlushchuk I, Coleman D, Heffner C, Horvath R, Battersby BJ, Burgess RW
Disease models & mechanisms 2025 May 1;18(5)
Disease models & mechanisms 2025 May 1;18(5)
UBASH3B-mediated MRPL12 Y60 dephosphorylation inhibits LUAD development by driving mitochondrial metabolism reprogramming.
Ji X, Zhang T, Sun J, Song X, Ma G, Xu L, Cao X, Jing Y, Xue F, Zhang W, Sun S, Wan Q, Liu Y
Journal of experimental & clinical cancer research : CR 2024 Sep 30;43(1):268
Journal of experimental & clinical cancer research : CR 2024 Sep 30;43(1):268
A roadmap for ribosome assembly in human mitochondria.
Lavdovskaia E, Hanitsch E, Linden A, Pašen M, Challa V, Horokhovskyi Y, Roetschke HP, Nadler F, Welp L, Steube E, Heinrichs M, Mai MM, Urlaub H, Liepe J, Richter-Dennerlein R
Nature structural & molecular biology 2024 Dec;31(12):1898-1908
Nature structural & molecular biology 2024 Dec;31(12):1898-1908
Sucrose Gradient Analysis of Human Mitochondrial Ribosomes and RNA.
Ng KY, Battersby BJ
Methods in molecular biology (Clifton, N.J.) 2023;2661:101-117
Methods in molecular biology (Clifton, N.J.) 2023;2661:101-117
Autoregulatory control of mitochondrial glutathione homeostasis.
Liu Y, Liu S, Tomar A, Yen FS, Unlu G, Ropek N, Weber RA, Wang Y, Khan A, Gad M, Peng J, Terzi E, Alwaseem H, Pagano AE, Heissel S, Molina H, Allwein B, Kenny TC, Possemato RL, Zhao L, Hite RK, Vinogradova EV, Mansy SS, Birsoy K
Science (New York, N.Y.) 2023 Nov 17;382(6672):820-828
Science (New York, N.Y.) 2023 Nov 17;382(6672):820-828
GTPBP8 is required for mitoribosomal biogenesis and mitochondrial translation.
Wang L, Hilander T, Liu X, Tsang HY, Eriksson O, Jackson CB, Varjosalo M, Zhao H
Cellular and molecular life sciences : CMLS 2023 Nov 16;80(12):361
Cellular and molecular life sciences : CMLS 2023 Nov 16;80(12):361
MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells.
Ji X, Chu L, Su D, Sun J, Song P, Sun S, Wang Y, Mu Q, Liu Y, Wan Q
iScience 2023 May 19;26(5):106656
iScience 2023 May 19;26(5):106656
Mitochondrial RNA methyltransferase TRMT61B is a new, potential biomarker and therapeutic target for highly aneuploid cancers.
Martín A, Epifano C, Vilaplana-Marti B, Hernández I, Macías RIR, Martínez-Ramírez Á, Cerezo A, Cabezas-Sainz P, Garranzo-Asensio M, Amarilla-Quintana S, Gómez-Domínguez D, Caleiras E, Camps J, Gómez-López G, Gómez de Cedrón M, Ramírez de Molina A, Barderas R, Sánchez L, Velasco-Miguel S, Pérez de Castro I
Cell death and differentiation 2023 Jan;30(1):37-53
Cell death and differentiation 2023 Jan;30(1):37-53
Cultured lymphocytes' mitochondrial genome integrity is not altered by cladribine.
Järvinen E, Suomi F, Stewart JB, Guala D, Valori M, Jansson L, Nieminen J, McWilliams TG, Tienari PJ
Clinical and experimental immunology 2023 Dec 13;214(3):304-313
Clinical and experimental immunology 2023 Dec 13;214(3):304-313
Nonstop mRNAs generate a ground state of mitochondrial gene expression noise.
Ng KY, Lutfullahoglu Bal G, Richter U, Safronov O, Paulin L, Dunn CD, Paavilainen VO, Richer J, Newman WG, Taylor RW, Battersby BJ
Science advances 2022 Nov 16;8(46):eabq5234
Science advances 2022 Nov 16;8(46):eabq5234
Translation of MT-ATP6 pathogenic variants reveals distinct regulatory consequences from the co-translational quality control of mitochondrial protein synthesis.
Ng KY, Richter U, Jackson CB, Seneca S, Battersby BJ
Human molecular genetics 2022 Apr 22;31(8):1230-1241
Human molecular genetics 2022 Apr 22;31(8):1230-1241
Mitochondrial stress response triggered by defects in protein synthesis quality control.
Richter U, Ng KY, Suomi F, Marttinen P, Turunen T, Jackson C, Suomalainen A, Vihinen H, Jokitalo E, Nyman TA, Isokallio MA, Stewart JB, Mancini C, Brusco A, Seneca S, Lombès A, Taylor RW, Battersby BJ
Life science alliance 2019 Feb;2(1)
Life science alliance 2019 Feb;2(1)
A variant in MRPS14 (uS14m) causes perinatal hypertrophic cardiomyopathy with neonatal lactic acidosis, growth retardation, dysmorphic features and neurological involvement.
Jackson CB, Huemer M, Bolognini R, Martin F, Szinnai G, Donner BC, Richter U, Battersby BJ, Nuoffer JM, Suomalainen A, Schaller A
Human molecular genetics 2019 Feb 15;28(4):639-649
Human molecular genetics 2019 Feb 15;28(4):639-649
RNA modification landscape of the human mitochondrial tRNA(Lys) regulates protein synthesis.
Richter U, Evans ME, Clark WC, Marttinen P, Shoubridge EA, Suomalainen A, Wredenberg A, Wedell A, Pan T, Battersby BJ
Nature communications 2018 Sep 27;9(1):3966
Nature communications 2018 Sep 27;9(1):3966
Adult-onset obesity is triggered by impaired mitochondrial gene expression.
Perks KL, Ferreira N, Richman TR, Ermer JA, Kuznetsova I, Shearwood AJ, Lee RG, Viola HM, Johnstone VPA, Matthews V, Hool LC, Rackham O, Filipovska A
Science advances 2017 Aug;3(8):e1700677
Science advances 2017 Aug;3(8):e1700677
Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome.
Lake NJ, Webb BD, Stroud DA, Richman TR, Ruzzenente B, Compton AG, Mountford HS, Pulman J, Zangarelli C, Rio M, Boddaert N, Assouline Z, Sherpa MD, Schadt EE, Houten SM, Byrnes J, McCormick EM, Zolkipli-Cunningham Z, Haude K, Zhang Z, Retterer K, Bai R, Calvo SE, Mootha VK, Christodoulou J, Rötig A, Filipovska A, Cristian I, Falk MJ, Metodiev MD, Thorburn DR
American journal of human genetics 2017 Aug 3;101(2):239-254
American journal of human genetics 2017 Aug 3;101(2):239-254
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Wang W, Wang L, Lu J, Siedlak SL, Fujioka H, Liang J, Jiang S, Ma X, Jiang Z, da Rocha EL, Sheng M, Choi H, Lerou PH, Li H, Wang X
Nature medicine 2016 Aug;22(8):869-78
Nature medicine 2016 Aug;22(8):869-78
Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness.
Richter U, Lahtinen T, Marttinen P, Suomi F, Battersby BJ
The Journal of cell biology 2015 Oct 26;211(2):373-89
The Journal of cell biology 2015 Oct 26;211(2):373-89
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 15543-1-AP(MRPL11 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 15543-1-AP(MRPL11 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MRPL11 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MRPL11. This antibody recognizes human, mouse, rat antigen. The MRPL11 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
