RA0309

antibody from Oursmab

Targeting: IFNAR1 IFNAR, IFRC

Western blot (Supportive data in Antibodypedia)

ELISA (Supportive data in Antibodypedia)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0309

Provider

Oursmab

Product name

Anifrolumab (Biosimilar Reference Antibody) (IFNAR1)

Antibody type

Monoclonal

Description

Anifrolumab is a fully human monoclonal antibody (IgG1¦Ê) approved for the treatment of moderate-to-severe systemic lupus erythematosus (SLE). It functions as a type I interferon (IFN) receptor antagonist, specifically binding to subunit 1 of the type I IFN receptor (IFNAR1). By blocking the receptor, it inhibits the signaling of all type I IFNs (including IFN-¦Á, IFN-¦Â, and IFN-¦Ø), which are central mediators of the autoimmune inflammation in SLE. Anifrolumab is administered via intravenous infusion and represents a targeted biologic therapy for patients with active, autoantibody-positive SLE who are receiving standard care.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.

Western blot

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

Anifrolumab (Biosimilar Reference Antibody) (IFNAR1)-RA0309-Oursmab determined by SDS-PAGE. The purity of the protein is greater than 98%.

ELISA

Supportive validation

Submitted by

Oursmab (provider)

Main image

Experimental details

ELISA plate pre-coated Antigen protein, can bind Anifrolumab (Biosimilar Reference Antibody) (IFNAR1)-RA0309 in a linear range of 3.91-125 ng/mL.