APG01236G

antibody from Leading Biology

Targeting: UBR2 bA49A4.1, C6orf133, dJ392M17.3, KIAA0349

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

APG01236G

Provider

Leading Biology

Product name

UBR2 Antibody (Internal)

Antibody type

Polyclonal

Description

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.

Reactivity

Human, Mouse, Rat, Bovine, Canine, Chicken/Avian, Hamster, Horse, Porcine, Rabbit, Simian

Host

Goat

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.