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- References [22]
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- Product number
- 18109-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18109-1-AP, RRID:AB_10665364
- Product name
- PRPH2 antibody
- Antibody type
- Polyclonal
- Description
- PRPH2 antibody (Cat. #18109-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Aggregation of the Constitutively Active K296E Rhodopsin Mutant Contributes to Retinal Degeneration.
Lack of retinal degeneration in a Dram2 knockout mouse model.
Prime editing for the investigation of aberrant splicing defect associated with a pathogenic PRPH2 variant.
Proteomics identifies multiple retinitis pigmentosa associated proteins involved in retinal degeneration in a mouse model bearing a Pde6b mutation.
Emc1 is essential for vision and zebrafish photoreceptor outer segment morphogenesis.
'Iterative Bleaching Extends Multiplexity' facilitates simultaneous identification of all major retinal cell types.
HBS1L deficiency causes retinal dystrophy in a child and in a mouse model associated with defective development of photoreceptor cells.
Complex N-glycosylation of mGluR6 is required for trans-synaptic interaction with ELFN adhesion proteins.
Deletion of Emc1 in photoreceptor cells causes retinal degeneration in mice.
Prph2 knock-in mice recapitulate human central areolar choroidal dystrophy retinal degeneration and exhibit aberrant synaptic remodeling and microglial activation.
Subretinal gene therapy delays vision loss in a Bardet-Biedl Syndrome type 10 mouse model.
A Genetic modification that reduces ON-bipolar cells in hESC-derived retinas enhances functional integration after transplantation.
Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance.
Hydrogel-mediated co-transplantation of retinal pigmented epithelium and photoreceptors restores vision in an animal model of advanced retinal degeneration.
Multimeric conformation of type III intermediate filaments but not the filamentous conformation exhibits high affinity to lipid bilayers.
The Late Endosomal Pathway Regulates the Ciliary Targeting of Tetraspanin Protein Peripherin 2.
The myosin-tail homology domain of centrosomal protein 290 is essential for protein confinement between the inner and outer segments in photoreceptors.
Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration.
Evaluation of micro Electroretinograms Recorded with Multiple Electrode Array to Assess Focal Retinal Function.
Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome.
BBS mutations modify phenotypic expression of CEP290-related ciliopathies.
Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation.
Vasudevan S, Prakash V, Park PS
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 31;39(14):e70848
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 31;39(14):e70848
Lack of retinal degeneration in a Dram2 knockout mouse model.
Sun K, Chen J, Fan Y, Cai J, Jiang X, Liu W, Zhu X
Vision research 2025 Jan;226:108509
Vision research 2025 Jan;226:108509
Prime editing for the investigation of aberrant splicing defect associated with a pathogenic PRPH2 variant.
Lopes da Costa B, Helms KM, Theodore K, Tsai YT, Caruso SM, Liu S, Lima de Carvalho JR, Nolan ND, Tahir S, Makinson CD, Tsang SH, Quinn PMJ
Molecular therapy. Nucleic acids 2025 Dec 9;36(4):102740
Molecular therapy. Nucleic acids 2025 Dec 9;36(4):102740
Proteomics identifies multiple retinitis pigmentosa associated proteins involved in retinal degeneration in a mouse model bearing a Pde6b mutation.
Yang M, Qiu R, Jin X, Yao S, Wang W, Liu J, Liu G, Han J, Lei B
Scientific reports 2024 Sep 27;14(1):22090
Scientific reports 2024 Sep 27;14(1):22090
Emc1 is essential for vision and zebrafish photoreceptor outer segment morphogenesis.
McCann T, Sundaramurthi H, Walsh C, Virdi S, Alvarez Y, Sapetto-Rebow B, Collery RF, Carter SP, Moran A, Mulholland R, O'Connor JJ, Taylor MR, Rauch N, Starostik MR, English MA, Swaroop A, Geisler R, Reynolds AL, Kennedy BN
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct 15;38(19):e70086
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct 15;38(19):e70086
'Iterative Bleaching Extends Multiplexity' facilitates simultaneous identification of all major retinal cell types.
Kothurkar AA, Patient GS, Noel NCL, Krzywańska AM, Carr BJ, Chu CJ, MacDonald RB
Journal of cell science 2024 Dec 1;137(23)
Journal of cell science 2024 Dec 1;137(23)
HBS1L deficiency causes retinal dystrophy in a child and in a mouse model associated with defective development of photoreceptor cells.
Luo S, Alwattar B, Li Q, Bora K, Blomfield AK, Lin J, Fulton A, Chen J, Agrawal PB
Disease models & mechanisms 2024 Aug 1;17(8)
Disease models & mechanisms 2024 Aug 1;17(8)
Complex N-glycosylation of mGluR6 is required for trans-synaptic interaction with ELFN adhesion proteins.
Miller ML, Pindwarawala M, Agosto MA
The Journal of biological chemistry 2024 Apr;300(4):107119
The Journal of biological chemistry 2024 Apr;300(4):107119
Deletion of Emc1 in photoreceptor cells causes retinal degeneration in mice.
Li X, Jiang Z, Su Y, Wang K, Jiang X, Sun K, Yang Y, Zhou Y, Zhu X, Zhang L
The FEBS journal 2023 Sep;290(17):4356-4370
The FEBS journal 2023 Sep;290(17):4356-4370
Prph2 knock-in mice recapitulate human central areolar choroidal dystrophy retinal degeneration and exhibit aberrant synaptic remodeling and microglial activation.
Ruiz-Pastor MJ, Sánchez-Sáez X, Kutsyr O, Albertos-Arranz H, Sánchez-Castillo C, Ortuño-Lizarán I, Martínez-Gil N, Vidal-Gil L, Méndez L, Sánchez-Martín M, Maneu V, Lax P, Cuenca N
Cell death & disease 2023 Nov 1;14(11):711
Cell death & disease 2023 Nov 1;14(11):711
Subretinal gene therapy delays vision loss in a Bardet-Biedl Syndrome type 10 mouse model.
Hsu Y, Bhattarai S, Thompson JM, Mahoney A, Thomas J, Mayer SK, Datta P, Garrison J, Searby CC, Vandenberghe LH, Seo S, Sheffield VC, Drack AV
Molecular therapy. Nucleic acids 2023 Mar 14;31:164-181
Molecular therapy. Nucleic acids 2023 Mar 14;31:164-181
A Genetic modification that reduces ON-bipolar cells in hESC-derived retinas enhances functional integration after transplantation.
Yamasaki S, Tu HY, Matsuyama T, Horiuchi M, Hashiguchi T, Sho J, Kuwahara A, Kishino A, Kimura T, Takahashi M, Mandai M
iScience 2022 Jan 21;25(1):103657
iScience 2022 Jan 21;25(1):103657
Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance.
Datta P, Cribbs JT, Seo S
PloS one 2021;16(5):e0246358
PloS one 2021;16(5):e0246358
Hydrogel-mediated co-transplantation of retinal pigmented epithelium and photoreceptors restores vision in an animal model of advanced retinal degeneration.
Mitrousis N, Hacibekiroglu S, Ho MT, Sauvé Y, Nagy A, van der Kooy D, Shoichet MS
Biomaterials 2020 Oct;257:120233
Biomaterials 2020 Oct;257:120233
Multimeric conformation of type III intermediate filaments but not the filamentous conformation exhibits high affinity to lipid bilayers.
Hwang B, Ise H
Genes to cells : devoted to molecular & cellular mechanisms 2020 Jun;25(6):413-426
Genes to cells : devoted to molecular & cellular mechanisms 2020 Jun;25(6):413-426
The Late Endosomal Pathway Regulates the Ciliary Targeting of Tetraspanin Protein Peripherin 2.
Otsu W, Hsu YC, Chuang JZ, Sung CH
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 May 1;39(18):3376-3393
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 May 1;39(18):3376-3393
The myosin-tail homology domain of centrosomal protein 290 is essential for protein confinement between the inner and outer segments in photoreceptors.
Datta P, Hendrickson B, Brendalen S, Ruffcorn A, Seo S
The Journal of biological chemistry 2019 Dec 13;294(50):19119-19136
The Journal of biological chemistry 2019 Dec 13;294(50):19119-19136
Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration.
Shirai H, Mandai M, Matsushita K, Kuwahara A, Yonemura S, Nakano T, Assawachananont J, Kimura T, Saito K, Terasaki H, Eiraku M, Sasai Y, Takahashi M
Proceedings of the National Academy of Sciences of the United States of America 2016 Jan 5;113(1):E81-90
Proceedings of the National Academy of Sciences of the United States of America 2016 Jan 5;113(1):E81-90
Evaluation of micro Electroretinograms Recorded with Multiple Electrode Array to Assess Focal Retinal Function.
Fujii M, Sunagawa GA, Kondo M, Takahashi M, Mandai M
Scientific reports 2016 Aug 2;6:30719
Scientific reports 2016 Aug 2;6:30719
Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome.
Datta P, Allamargot C, Hudson JS, Andersen EK, Bhattarai S, Drack AV, Sheffield VC, Seo S
Proceedings of the National Academy of Sciences of the United States of America 2015 Aug 11;112(32):E4400-9
Proceedings of the National Academy of Sciences of the United States of America 2015 Aug 11;112(32):E4400-9
BBS mutations modify phenotypic expression of CEP290-related ciliopathies.
Zhang Y, Seo S, Bhattarai S, Bugge K, Searby CC, Zhang Q, Drack AV, Stone EM, Sheffield VC
Human molecular genetics 2014 Jan 1;23(1):40-51
Human molecular genetics 2014 Jan 1;23(1):40-51
Reversal of end-stage retinal degeneration and restoration of visual function by photoreceptor transplantation.
Singh MS, Charbel Issa P, Butler R, Martin C, Lipinski DM, Sekaran S, Barnard AR, MacLaren RE
Proceedings of the National Academy of Sciences of the United States of America 2013 Jan 15;110(3):1101-6
Proceedings of the National Academy of Sciences of the United States of America 2013 Jan 15;110(3):1101-6
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse eye tissue were subjected to SDS PAGE followed by western blot with 18109-1-AP(PRPH2 antibody) at dilution of 1:500
- Sample type
- tissue
