APR02328G
antibody from Leading Biology
Targeting: SEM1
C7orf76, DSS1, ECD, FLJ42280, SHFD1, Shfdg1, SHFM1, SHSF1
Antibody data
- Antibody Data
- Antigen structure
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- Validations [0]
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- Product number
- APR02328G - Provider product page
- Provider
- Leading Biology
- Product name
- SHSF1 / SHFM1 Antibody (aa57-70)
- Antibody type
- Polyclonal
- Description
- Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription- associated genomic instability. R-loop accumulation increases in DSS1-depleted cells.
- Reactivity
- Human
- Host
- Rabbit
- Storage
- Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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