14681-1-AP

antibody from Proteintech Group

Targeting: ASNS

Provider product page for 14681-1-AP

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ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [83]
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Validations
Western blot [1]

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Product number: 14681-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14681-1-AP, RRID:AB_2060119
Product name: ASNS antibody
Antibody type: Polyclonal
Description: KD/KO validated ASNS antibody (Cat. #14681-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ASNS protein structure - 14681-1-AP shown in red.

Submitted references ETV4 Promotes Colorectal Cancer Progression by Reprogramming Asparagine Metabolism to Remodel the Stromal Microenvironment.

Fu D, Zhang M, Cai M, Wang M, Huang Z, Lin Z, Liu Y, Qian W, Chen G, Liang Y, Wei D, Xie J, Yan P, Qu Y, Wei Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(26):e16557

Txnrd2 loss in skeletal muscle causes muscle atrophy and drives leanness and obesity resistance.

Kiermayer C, Erdelen R, Schriever SC, Böhm R, Prehn C, Artati A, Kleinert M, Miller M, Dyar KA, Schmid RM, Pfluger PT, Adamski J, Brielmeier M
Redox biology 2026 Jun;93:104165

Nutrient requirements of organ-specific metastasis in breast cancer.

Abbott KL, Subudhi S, Ferreira R, Gültekin Y, Steinbuch SC, Munim MB, Ramesh DL, Honeder SE, Kumar AS, Wu M, Hansen JA, Shevzov-Zebrun A, Rashan EH, Eghbalian KM, Sivanand S, Barbeau AM, Riedmayr LM, Duquette M, Ali A, Henning N, Trojan SE, Waite M, Kunchok T, Nakano MA, Gourgue F, Ferraro GB, Do BT, Spanoudaki V, Sánchez-Rivera FJ, Jin X, Church GM, Jain RK, Vander Heiden MG
Nature 2026 Jan;649(8099):1292-1301

Tumor metabolic adaptation induced by L-asparaginase reveals a vulnerability to PARP1/2 inhibitor in B-cell lymphomas.

Aussel A, Nemazanyy I, Vandenberghe A, Meola P, Dorat N, Paul R, Habbouche L, Exposito L, Nottet N, Petrilli V, Chiche E, Mounier N, Marchetti S, Chaveroux C, Ricci JE, Chiche J
Nature communications 2026 Feb 27;17(1)

Asparagine sensing by TBK1 controls its phase separation to drive antiviral innate immune responses.

Du J, Li C, Chai L, Zhao F, Lv L, Yang Z, Zhao Z, Gong R, Yang L, Wu M, Nie M, Jia J, Kang D, Gao C, Zhao W, Jia M
Molecular cell 2026 Feb 19;86(4):722-739.e8

The role of glutamine/Nrf2-enhanced PHGDH in Cadmium-induced lactate utilization.

Pang Y, Li S, Zhang Q, Liu Y, Kong Y, Cao J
Free radical biology & medicine 2026 Feb 16;244:296-311

Ageing promotes metastasis via activation of the integrated stress response.

Patel AAH, Dzanan JJ, Ali KX, Eklund EA, Alvarez SW, Raj D, Dankis M, Altinönder I, Schwarz M, Le Gal K, Bedel E, El Zowalaty AE, Jonasson E, Albatrok H, Gul N, Bossowski JP, Pillai R, Micke P, Botling J, Akyürek LM, Angeletti D, Sayin SI, Härtlova A, Papagiannakopoulos T, Olofsson Bagge R, Ståhlberg A, Hallqvist A, Wiel C, Sayin VI
Nature 2026 Apr;652(8112):1339-1348

Mitochondrial protein import stress causes lysosomal damage and progressive tissue atrophy.

Brennan NA, Wang X, Rana A, Bhagwagar SZ, Horton J, Kane PM, Chen XJ
EMBO reports 2026 Apr 27;

Lung Cancer Cell-intrinsic Asparagine Synthetase Potentiates Anti-Tumor Immunity via Modulating Immunogenicity and Facilitating Immune Remodeling in Metastatic Tumor-draining Lymph Nodes.

Zhang Z, Du N, He G, Zhang M, Zhang G, Gao J, Liu Y, Deng Y, Sun L, Li M
International journal of biological sciences 2025;21(14):6501-6521

Small molecule inhibition of ubiquitin C-terminal hydrolase L1 alters cell metabolism proteins and exerts anti- or pro-tumorigenic effects contingent upon chemosensitivity status in high grade serous ovarian cancer.

Jansen C, McAdams J, Kim C, De La Cruz P, Salaverria A, DaSilva NA, Grive K, James NE
Frontiers in pharmacology 2025;16:1547164

PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer.

Arora GK, Loughran RM, Ly K, Galapate CM, Llorente A, Anderson TR, Zhang CY, Grenier SF, Ling L, Crabtree S, Lambies G, Pauli C, Scott DA, Altman Y, Portillo B, Murad R, Commisso C, Emerling BM
Cell reports 2025 Sep 23;44(9):116199

Asparagine synthetase modulates glutaminase inhibitor sensitivity through metabolic reprogramming and serves as a prognostic biomarker in hepatocellular carcinoma.

Gao B, Zheng D, Liu H, Guo Y, Ye Y, Chen Z, Yang F, Liu J, Zhang G, Feng G, Liu Y, Wang Q, Su S, Yang X, Li B
Redox biology 2025 Oct;86:103813

Asparaginase and Autophagy Inhibitors Effectively Remove Senescent Cells by Synergistically Limiting Asparagine Supply.

Huang Z, Liu X, Zhou X, Chen K, Diao H, Wang M, Wei J, Li Z, Yang Y, Mao Z, Yu W
Aging cell 2025 Oct;24(10):e70203

ASNS Regulates H(2)O(2)-Induced Senescence, Oxidative Stress, and Glucose Metabolism in ARPE-19 Cells by Modulating USP13 Expression.

Xin X, Zhao X, Han X, Pu W
BioFactors (Oxford, England) 2025 Nov-Dec;51(6):e70057

Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma using Data-Independent Acquisition Mass Spectrometry.

Barny LA, Hermanson JN, Garcia SK, Stauffer PE, Plate L
bioRxiv : the preprint server for biology 2025 Mar 24;

Application of a Multiomics Imaging Workflow to Explore Asparlas Treatment in Solid Tumors.

van der Vloet L, Mohren R, Bouillod C, Heeren RMA, Vandenbosch M, Barbier Saint Hilaire P
Analytical chemistry 2025 Jun 24;97(24):12736-12745

FAM50A drives breast cancer brain metastasis through interaction with C9ORF78 to enhance ʟ-asparagine production.

Chen W, Qin Y, Qiao L, Liu X, Gao C, Li TR, Luo Y, Li D, Yan H, Han L, Hai L, Nie F, Wu HB, Chen C, Ping YF, Bian XW
Science advances 2025 Jun 20;11(25):eadt3075

Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma Using Data-Independent Acquisition Mass Spectrometry.

Barny LA, Hermanson JN, Garcia SK, Stauffer PE, Plate L
Molecular & cellular proteomics : MCP 2025 Aug;24(8):101036

The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury.

Novak JSS, Polak L, Baksh SC, Barrows DW, Schernthanner M, Jackson BT, Thompson EAN, Gola A, Abdusselamoglu MD, Bonny AR, Gonzales KAU, Brunner JS, Bridgeman AE, Stewart KS, Hidalgo L, Dela Cruz-Racelis J, Luo JD, Gur-Cohen S, Pasolli HA, Carroll TS, Finley LWS, Fuchs E
Cell metabolism 2025 Aug 5;37(8):1715-1731.e11

DKC1-mediated pseudouridylation of rRNA targets hnRNP A1 to sustain IRES-dependent translation and ATF4-driven metabolic adaptation.

Gupta A, Bansal M, Ding J, Karki S, Pandit M, Sudarshan S, Ding HF
Science advances 2025 Aug 29;11(35):eadv9401

Arginine depletion potentiates standard-of-care chemo-immunotherapy in preclinical models of high-risk neuroblastoma.

Hanssen KM, Murray J, Pandher R, Alfred S, Gamble LD, Brand J, Mosmann E, Kusuma FK, Mak C, Kearns A, Kamili A, Atkinson C, Minchaca AZ, Bertoldo J, Ziegler DS, Mussai F, Cheng PNM, Norris MD, Fletcher JI, Haber M
Journal of experimental & clinical cancer research : CR 2025 Aug 14;44(1):239

Proteostasis and Unfolded Protein Response Dynamics in Human Neuron and Mouse Glia Co-culture Reveal Cell-Specific Aging Responses.

Barny LA, Garcia SK, Houcek AJ, Uzay B, Kim M, Kavalali ET, Plate L
bioRxiv : the preprint server for biology 2025 Aug 13;

The mevalonate pathway couples lipid metabolism to amino acid synthesis via ubiquinone-dependent redox control.

Nguyen TT, Bansal M, Ding J, Sudarshan S, Ding HF
bioRxiv : the preprint server for biology 2025 Aug 12;

GPS2 confers l-asparaginase resistance in acute lymphoblastic leukemia cells through ATF4/ASNS axis.

Chen J, Luo J, Liu Y, Zhou J, Cui H, Deng L
Carcinogenesis 2025 Apr 3;46(2)

Asparagine drives immune evasion in bladder cancer via RIG-I stability and type I IFN signaling.

Wei W, Li H, Tian S, Zhang C, Liu J, Tao W, Cai T, Dong Y, Wang C, Lu D, Ai Y, Zhang W, Wang H, Liu K, Fan Y, Gao Y, Huang Q, Ma X, Wang B, Zhang X, Huang Y
The Journal of clinical investigation 2025 Apr 15;135(8)

METTL3 Inhibition Suppresses Cell Growth and Survival in Colorectal Cancer via ASNS Downregulation.

Yu Y, Hai Y, Zhou H, Bao W, Hu X, Gao Y, Wu J
Journal of Cancer 2024;15(15):4853-4865

HMGA2-mediated glutamine metabolism is required for Cd-induced cell growth and cell migration.

Yang Y, Gao C, Li Q, Liu Y, Cao J
Toxicology 2024 Sep;507:153899

Asparagine Availability Is a Critical Limiting Factor for Infectious Spleen and Kidney Necrosis Virus Replication.

Ma B, Li F, Fu X, Luo X, Lin Q, Liang H, Niu Y, Li N
Viruses 2024 Sep 29;16(10)

Targeting NAT10 inhibits osteosarcoma progression via ATF4/ASNS-mediated asparagine biosynthesis.

Zou Y, Guo S, Wen L, Lv D, Tu J, Liao Y, Chen W, Chen Z, Li H, Chen J, Shen J, Xie X
Cell reports. Medicine 2024 Sep 17;5(9):101728

Asparagine Dependency Is a Targetable Metabolic Vulnerability in TP53-Altered Castration-Resistant Prostate Cancer.

Yoo YA, Quan S, Yang W, Guo Q, Rodríguez Y, Chalmers ZR, Dufficy MF, Lackie B, Sagar V, Unno K, Truica MI, Chandel NS, Abdulkadir SA
Cancer research 2024 Sep 16;84(18):3004-3022

Site of breast cancer metastasis is independent of single nutrient levels.

Abbott KL, Subudhi S, Ferreira R, Gültekin Y, Steinbuch SC, Munim MB, Honeder SE, Kumar AS, Ramesh DL, Wu M, Hansen JA, Sivanand S, Riedmayr LM, Duquette M, Ali A, Henning N, Shevzov-Zebrun A, Gourgue F, Barbeau AM, Waite M, Kunchok T, Ferraro GB, Do BT, Spanoudaki V, Sánchez-Rivera FJ, Jin X, Church GM, Jain RK, Vander Heiden MG
bioRxiv : the preprint server for biology 2024 Oct 25;

l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models.

Kundu A, Brinkley GJ, Nam H, Karki S, Kirkman R, Pandit M, Shim E, Widden H, Liu J, Heidarian Y, Mahmoudzadeh NH, Fitt AJ, Absher D, Ding HF, Crossman DK, Placzek WJ, Locasale JW, Rakheja D, McConathy JE, Ramachandran R, Bae S, Tennessen JM, Sudarshan S
The Journal of clinical investigation 2024 May 14;134(13)

AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis.

Deng B, Liu F, Chen N, Li X, Lei J, Chen N, Wu J, Wang X, Lu J, Fang M, Chen A, Zhang Z, He B, Yan M, Zhang Y, Wang Z, Liu Q
Cell death & disease 2024 Mar 23;15(3):233

Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma.

Recouvreux MV, Grenier SF, Zhang Y, Esparza E, Lambies G, Galapate CM, Maganti S, Duong-Polk K, Bhullar D, Naeem R, Scott DA, Lowy AM, Tiriac H, Commisso C
Nature cancer 2024 Jan;5(1):100-113

MYC Drives mRNA Pseudouridylation to Mitigate Proliferation-Induced Cellular Stress during Cancer Development.

Ding J, Bansal M, Cao Y, Ye B, Mao R, Gupta A, Sudarshan S, Ding HF
Cancer research 2024 Dec 2;84(23):4031-4048

DKC1-mediated pseudouridylation of rRNA targets hnRNP A1 to sustain IRES-dependent translation and ATF4-driven metabolic adaptation.

Gupta A, Bansal M, Ding J, Pandit M, Sudarshan S, Ding HF
bioRxiv : the preprint server for biology 2024 Dec 17;

Pyruvate metabolism dictates fibroblast sensitivity to GLS1 inhibition during fibrogenesis.

Contento G, Wilson JA, Selvarajah B, Platé M, Guillotin D, Morales V, Trevisani M, Pitozzi V, Bianchi K, Chambers RC
JCI insight 2024 Aug 13;9(18)

Role of asparagine biosynthesis pathway in Siniperca chuatsi rhabdovirus proliferation.

Li F, Fu X, Luo X, Lin Q, Liang H, Niu Y, Liu L, Li N
Frontiers in microbiology 2023;14:1165491

Lipoylation is dependent on the ferredoxin FDX1 and dispensable under hypoxia in human cells.

Joshi PR, Sadre S, Guo XA, McCoy JG, Mootha VK
The Journal of biological chemistry 2023 Sep;299(9):105075

Methylseleninic acid overcomes gefitinib resistance through asparagine-MET-TOPK signaling axis in non-small cell lung cancer cells.

Cui J, Zhao S, Chen H, Fu Y, Han K, Yin S, Zhao C, Fan L, Hu H
Biochemical pharmacology 2023 Sep;215:115690

A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.

Southwell N, Primiano G, Nadkarni V, Attarwala N, Beattie E, Miller D, Alam S, Liparulo I, Shurubor YI, Valentino ML, Carelli V, Servidei S, Gross SS, Manfredi G, Chen Q, D'Aurelio M
EMBO molecular medicine 2023 Jul 10;15(7):e16951

Arginine limitation drives a directed codon-dependent DNA sequence evolution response in colorectal cancer cells.

Hsu DJ, Gao J, Yamaguchi N, Pinzaru A, Wu Q, Mandayam N, Liberti M, Heissel S, Alwaseem H, Tavazoie S, Tavazoie SF
Science advances 2023 Jan 6;9(1):eade9120

Arginine limitation causes a directed DNA sequence evolution response in colorectal cancer cells.

Hsu DJ, Gao J, Yamaguchi N, Pinzaru A, Mandayam N, Liberti M, Heissel S, Alwaseem H, Tavazoie S, Tavazoie SF
bioRxiv : the preprint server for biology 2023 Jan 2;

Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells.

Linder SJ, Bernasocchi T, Martínez-Pastor B, Sullivan KD, Galbraith MD, Lewis CA, Ferrer CM, Boon R, Silveira GG, Cho HM, Vidoudez C, Shroff S, Oliveira-Costa JP, Ross KN, Massri R, Matoba Y, Kim E, Rueda BR, Stott SL, Gottlieb E, Espinosa JM, Mostoslavsky R
Nature metabolism 2023 Dec;5(12):2131-2147

PERK Inhibition by HC-5404 Sensitizes Renal Cell Carcinoma Tumor Models to Antiangiogenic Tyrosine Kinase Inhibitors.

Stokes ME, Calvo V, Fujisawa S, Dudgeon C, Huang S, Ballal N, Shen L, Gasparek J, Betzenhauser M, Taylor SJ, Staschke KA, Rigby AC, Mulvihill MJ, Bose N, Lightcap ES, Surguladze D
Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Dec 1;29(23):4870-4882

NUCKS1, a LINC00629-upregulated gene, facilitated osteosarcoma progression and metastasis by elevating asparagine synthesis.

Zheng S, Ji R, He H, Li N, Han C, Han J, Li X, Zhang L, Wang Y, Zhao W
Cell death & disease 2023 Aug 1;14(8):489

Asparagine starvation suppresses histone demethylation through iron depletion.

Jiang J, Srivastava S, Liu S, Seim G, Claude R, Zhong M, Cao S, Davé U, Kapur R, Mosley AL, Zhang C, Wan J, Fan J, Zhang J
iScience 2023 Apr 21;26(4):106425

UCP2 silencing restrains leukemia cell proliferation through glutamine metabolic remodeling.

Sancerni T, Renoult O, Luby A, Caradeuc C, Lenoir V, Croyal M, Ransy C, Aguilar E, Postic C, Bertho G, Dentin R, Prip-Buus C, Pecqueur C, Alves-Guerra MC
Frontiers in immunology 2022;13:960226

Transcriptome and Proteome Analysis in LUHMES Cells Overexpressing Alpha-Synuclein.

Höllerhage M, Stepath M, Kohl M, Pfeiffer K, Chua OWH, Duan L, Hopfner F, Eisenacher M, Marcus K, Höglinger GU
Frontiers in neurology 2022;13:787059

Transcriptional and metabolic remodeling in clear cell renal cell carcinoma caused by ATF4 activation and the integrated stress response (ISR).

van der Mijn JC, Chen Q, Laursen KB, Khani F, Wang X, Dorsaint P, Sboner A, Gross SS, Nanus DM, Gudas LJ
Molecular carcinogenesis 2022 Sep;61(9):851-864

Cellular and molecular characterization of two novel asparagine synthetase gene mutations linked to asparagine synthetase deficiency.

Staklinski SJ, Chang MC, Yu F, Collins Ruff K, Franz DN, Qian Z, Bloom LB, Merritt ME, McKenna R, Kilberg MS
The Journal of biological chemistry 2022 Sep;298(9):102385

Asparagine bioavailability regulates the translation of MYC oncogene.

Srivastava S, Jiang J, Misra J, Seim G, Staschke KA, Zhong M, Zhou L, Liu Y, Chen C, Davé U, Kapur R, Batra S, Zhang C, Zhou J, Fan J, Wek RC, Zhang J
Oncogene 2022 Oct;41(44):4855-4865

Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.

Jiang B, Zhang J, Zhao G, Liu M, Hu J, Lin F, Wang J, Zhao W, Ma H, Zhang C, Wu C, Yao L, Liu Q, Chen X, Cao Y, Zheng Y, Zhang C, Han A, Lin D, Li Q
Molecular cell 2022 May 19;82(10):1821-1835.e6

Tumoral microenvironment prevents de novo asparagine biosynthesis in B cell lymphoma, regardless of ASNS expression.

Grima-Reyes M, Vandenberghe A, Nemazanyy I, Meola P, Paul R, Reverso-Meinietti J, Martinez-Turtos A, Nottet N, Chan WK, Lorenzi PL, Marchetti S, Ricci JE, Chiche J
Science advances 2022 Jul 8;8(27):eabn6491

CHCHD2 and CHCHD10 regulate mitochondrial dynamics and integrated stress response.

Ruan Y, Hu J, Che Y, Liu Y, Luo Z, Cheng J, Han Q, He H, Zhou Q
Cell death & disease 2022 Feb 16;13(2):156

A Novel Ferroptosis-Based Molecular Signature Associated with Biochemical Recurrence-Free Survival and Tumor Immune Microenvironment of Prostate Cancer.

Ke ZB, You Q, Sun JB, Zhu JM, Li XD, Chen DN, Su L, Zheng QS, Wei Y, Xue XY, Xu N
Frontiers in cell and developmental biology 2021;9:774625

Enhanced Antitumor Effect in Liver Cancer by Amino Acid Depletion-Induced Oxidative Stress.

Okuda K, Umemura A, Kataoka S, Yano K, Takahashi A, Okishio S, Taketani H, Seko Y, Nishikawa T, Yamaguchi K, Moriguchi M, Nakagawa H, Liu Y, Mitsumoto Y, Kanbara Y, Shima T, Okanoue T, Itoh Y
Frontiers in oncology 2021;11:758549

Asparagine Synthetase-Mediated l-Asparagine Metabolism Disorder Promotes the Perineural Invasion of Oral Squamous Cell Carcinoma.

Fu Y, Ding L, Yang X, Ding Z, Huang X, Zhang L, Chen S, Hu Q, Ni Y
Frontiers in oncology 2021;11:637226

Canagliflozin Improves Liver Function in Rats by Upregulating Asparagine Synthetase.

Wang S, Ding Y, Dong R, Wang H, Yin L, Meng S
Pharmacology 2021;106(11-12):606-615

Adaptation of the heart to Frataxin depletion: Evidence that integrated stress response can predominate over mTORC1 activation.

Vásquez-Trincado C, Patel M, Sivaramakrishnan A, Bekeová C, Anderson-Pullinger L, Wang N, Tang HY, Seifert EL
Human molecular genetics 2021 Sep 22;33(8):637-54

Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.

Krall AS, Mullen PJ, Surjono F, Momcilovic M, Schmid EW, Halbrook CJ, Thambundit A, Mittelman SD, Lyssiotis CA, Shackelford DB, Knott SRV, Christofk HR
Cell metabolism 2021 May 4;33(5):1013-1026.e6

Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms.

Apfel V, Begue D, Cordo' V, Holzer L, Martinuzzi L, Buhles A, Kerr G, Barbosa I, Naumann U, Piquet M, Ruddy D, Weiss A, Ferretti S, Almeida R, Bonenfant D, Tordella L, Galli GG
ACS pharmacology & translational science 2021 Feb 12;4(1):327-337

JMJD2B-induced amino acid alterations enhance the survival of colorectal cancer cells under glucose-deprivation via autophagy.

Tan J, Wang HL, Yang J, Liu QQ, Li CM, Wang YQ, Fu LN, Gao QY, Chen YX, Fang JY
Theranostics 2020;10(13):5763-5777

Glutamine depletion regulates Slug to promote EMT and metastasis in pancreatic cancer.

Recouvreux MV, Moldenhauer MR, Galenkamp KMO, Jung M, James B, Zhang Y, Lowy A, Bagchi A, Commisso C
The Journal of experimental medicine 2020 Sep 7;217(9)

Glutamine and asparagine activate mTORC1 independently of Rag GTPases.

Meng D, Yang Q, Wang H, Melick CH, Navlani R, Frank AR, Jewell JL
The Journal of biological chemistry 2020 Mar 6;295(10):2890-2899

p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival.

Deng L, Yao P, Li L, Ji F, Zhao S, Xu C, Lan X, Jiang P
Nature communications 2020 Apr 9;11(1):1755

ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase.

Williams RT, Guarecuco R, Gates LA, Barrows D, Passarelli MC, Carey B, Baudrier L, Jeewajee S, La K, Prizer B, Malik S, Garcia-Bermudez J, Zhu XG, Cantor J, Molina H, Carroll T, Roeder RG, Abdel-Wahab O, Allis CD, Birsoy K
Cell metabolism 2020 Apr 7;31(4):852-861.e6

Suppression of asparagine synthetase enhances the antitumor potency of ART and artemalogue SOMCL-14-221 in non-small cell lung cancer.

Xiao R, Ding C, Zhu H, Liu X, Gao J, Liu Q, Lu D, Zhang N, Zhang A, Zhou H
Cancer letters 2020 Apr 10;475:22-33

Amino acids signatures of distance-related surgical margins of oral squamous cell carcinoma.

Yang XH, Zhang XX, Jing Y, Ding L, Fu Y, Wang S, Hu SQ, Zhang L, Huang XF, Ni YH, Hu QG
EBioMedicine 2019 Oct;48:81-91

Asparagine Deprivation Causes a Reversible Inhibition of Human Cytomegalovirus Acute Virus Replication.

Lee CH, Griffiths S, Digard P, Pham N, Auer M, Haas J, Grey F
mBio 2019 Oct 8;10(5)

Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer.

Lukey MJ, Cluntun AA, Katt WP, Lin MJ, Druso JE, Ramachandran S, Erickson JW, Le HH, Wang ZE, Blank B, Greene KS, Cerione RA
Cell reports 2019 Oct 1;29(1):76-88.e7

The landscape of cancer cell line metabolism.

Li H, Ning S, Ghandi M, Kryukov GV, Gopal S, Deik A, Souza A, Pierce K, Keskula P, Hernandez D, Ann J, Shkoza D, Apfel V, Zou Y, Vazquez F, Barretina J, Pagliarini RA, Galli GG, Root DE, Hahn WC, Tsherniak A, Giannakis M, Schreiber SL, Clish CB, Garraway LA, Sellers WR
Nature medicine 2019 May;25(5):850-860

Asparagine Is a Critical Limiting Metabolite for Vaccinia Virus Protein Synthesis during Glutamine Deprivation.

Pant A, Cao S, Yang Z
Journal of virology 2019 Jul 1;93(13)

Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion.

Jiang J, Srivastava S, Seim G, Pavlova NN, King B, Zou L, Zhang C, Zhong M, Feng H, Kapur R, Wek RC, Fan J, Zhang J
The Journal of biological chemistry 2019 Dec 6;294(49):18674-18684

Autophagic reliance promotes metabolic reprogramming in oncogenic KRAS-driven tumorigenesis.

Lin HH, Chung Y, Cheng CT, Ouyang C, Fu Y, Kuo CY, Chi KK, Sadeghi M, Chu P, Kung HJ, Li CF, Limesand KH, Ann DK
Autophagy 2018;14(9):1481-1498

Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction.

Cheng CT, Qi Y, Wang YC, Chi KK, Chung Y, Ouyang C, Chen YR, Oh ME, Sheng X, Tang Y, Liu YR, Lin HH, Kuo CY, Schones D, Vidal CM, Chu JC, Wang HJ, Chen YH, Miller KM, Chu P, Yen Y, Jiang L, Kung HJ, Ann DK
Communications biology 2018;1:178

Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers.

Kremer JC, Prudner BC, Lange SES, Bean GR, Schultze MB, Brashears CB, Radyk MD, Redlich N, Tzeng SC, Kami K, Shelton L, Li A, Morgan Z, Bomalaski JS, Tsukamoto T, McConathy J, Michel LS, Held JM, Van Tine BA
Cell reports 2017 Jan 24;18(4):991-1004

Loss of asparagine synthetase suppresses the growth of human lung cancer cells by arresting cell cycle at G0/G1 phase.

Xu Y, Lv F, Zhu X, Wu Y, Shen X
Cancer gene therapy 2016 Sep;23(9):287-94

Knockdown of asparagine synthetase by RNAi suppresses cell growth in human melanoma cells and epidermoid carcinoma cells.

Li H, Zhou F, Du W, Dou J, Xu Y, Gao W, Chen G, Zuo X, Sun L, Zhang X, Yang S
Biotechnology and applied biochemistry 2016 May;63(3):328-33

Transcriptome Analysis of Piperlongumine-Treated Human Pancreatic Cancer Cells Reveals Involvement of Oxidative Stress and Endoplasmic Reticulum Stress Pathways.

Dhillon H, Mamidi S, McClean P, Reindl KM
Journal of medicinal food 2016 Jun;19(6):578-85

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor.

Krall AS, Xu S, Graeber TG, Braas D, Christofk HR
Nature communications 2016 Apr 29;7:11457

Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.

Zhang J, Fan J, Venneti S, Cross JR, Takagi T, Bhinder B, Djaballah H, Kanai M, Cheng EH, Judkins AR, Pawel B, Baggs J, Cherry S, Rabinowitz JD, Thompson CB
Molecular cell 2014 Oct 23;56(2):205-218

Down-regulation of asparagine synthetase induces cell cycle arrest and inhibits cell proliferation of breast cancer.

Yang H, He X, Zheng Y, Feng W, Xia X, Yu X, Lin Z
Chemical biology & drug design 2014 Nov;84(5):578-84

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The ASNS antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ASNS. This antibody recognizes human,mouse,rat antigen. The ASNS antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 14681-1-AP.pdf

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