HPA029318

antibody from Atlas Antibodies

Targeting: ASNS

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

HPA029318

Provider

Atlas Antibodies

Proper citation

Atlas Antibodies Cat#HPA029318, RRID:AB_10602389

Product name

Anti-ASNS

Antibody type

Polyclonal

Description

Polyclonal Antibody against Human ASNS, Gene description: asparagine synthetase (glutamine-hydrolyzing), Validated applications: WB, IHC, Uniprot ID: P08243, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

0.2 mg/ml

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling

The antibody solution should be gently mixed before use.

References

Submitted references

Targeting Asparagine Metabolism in Well-Differentiated/Dedifferentiated Liposarcoma

Klingbeil K, Wilde B, Graham D, Lofftus S, McCaw T, Matulionis N, Dry S, Crompton J, Eilber F, Graeber T, Shackelford D, Christofk H, Kadera B
Cancers 2024;16(17):3031

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Loss of attachment promotes proline accumulation and excretion in cancer cells.

Pilley SE, Hennequart M, Vandekeere A, Blagih J, Legrave NM, Fendt SM, Vousden KH, Labuschagne CF
Science advances 2023 Sep 8;9(36):eadh2023

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Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL.

Akahane K, Kimura S, Miyake K, Watanabe A, Kagami K, Yoshimura K, Shinohara T, Harama D, Kasai S, Goi K, Kawai T, Hata K, Kiyokawa N, Koh K, Imamura T, Horibe K, Look AT, Minegishi M, Sugita K, Takita J, Inukai T
Blood advances 2022 Jan 11;6(1):212-224

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Asparagine Synthetase-Mediated l-Asparagine Metabolism Disorder Promotes the Perineural Invasion of Oral Squamous Cell Carcinoma

Fu Y, Ding L, Yang X, Ding Z, Huang X, Zhang L, Chen S, Hu Q, Ni Y
Frontiers in Oncology 2021;11

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Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation.

Hope HC, Brownlie RJ, Fife CM, Steele L, Lorger M, Salmond RJ
JCI insight 2021 May 10;6(9)

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Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy.

Tajan M, Hennequart M, Cheung EC, Zani F, Hock AK, Legrave N, Maddocks ODK, Ridgway RA, Athineos D, Suárez-Bonnet A, Ludwig RL, Novellasdemunt L, Angelis N, Li VSW, Vlachogiannis G, Valeri N, Mainolfi N, Suri V, Friedman A, Manfredi M, Blyth K, Sansom OJ, Vousden KH
Nature communications 2021 Jan 14;12(1):366

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Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL.

Watanabe A, Miyake K, Nordlund J, Syvänen AC, van der Weyden L, Honda H, Yamasaki N, Nagamachi A, Inaba T, Ikawa T, Urayama KY, Kiyokawa N, Ohara A, Kimura S, Kubota Y, Takita J, Goto H, Sakaguchi K, Minegishi M, Iwamoto S, Shinohara T, Kagami K, Abe M, Akahane K, Goi K, Sugita K, Inukai T
Blood 2020 Nov 12;136(20):2319-2333

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Aspartate is an endogenous metabolic limitation for tumour growth

Sullivan L, Luengo A, Danai L, Bush L, Diehl F, Hosios A, Lau A, Elmiligy S, Malstrom S, Lewis C, Vander Heiden M
Nature Cell Biology 2018;20(7):782-788

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The Beta-adrenergic agonist, Ractopamine, increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program.

Brown D, Ryan K, Daniel Z, Mareko M, Talbot R, Moreton J, Giles TCB, Emes R, Hodgman C, Parr T, Brameld JM
Scientific reports 2018 Oct 29;8(1):15915

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Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma

Hettmer S, Schinzel A, Tchessalova D, Schneider M, Parker C, Bronson R, Richards N, Hahn W, Wagers A
eLife 2015;4