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- Antigen structure
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- Western blot [1]
- Immunoprecipitation [1]
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- Product number
- 14395-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14395-1-AP, RRID:AB_2223009
- Product name
- smooth muscle actin antibody
- Antibody type
- Polyclonal
- Description
- smooth muscle actin antibody (Cat. #14395-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Metabolomics Reveals the Anti-hepatic Fibrosis Mechanisms of Pueraria lobata (Willd.) Ohwi Extract and Potential Metabolites Alterations.
Engineering exosomes with iRGD for targeted RNAi therapy against pancreatic cancer mediated by long non-coding RNA PLBD1-AS1.
Huanggan decoction ameliorates cholestatic hepatic fibrosis in rats via TGF-β1/Smad3 signaling pathway.
Arachidonic Acid-Induced Contraction of Smooth Muscle Is Mediated by MLC Phosphorylation in Preterm Birth.
PAPPA2 c.392G>C Heterozygous Mutation Associates Primary Open-Angle Glaucoma in a Chinese Family.
Adipose Mesenchymal Stem Cells Promote Wound Healing by Modulating Expression of SERPINE1 in Dermal Fibroblasts and Keratinocytes.
Targeting Pulmonary Hypertension: Elucidating Sophocarpine's Protective Role via Preclinical Models.
Integrated Mendelian Randomization and Single-Cell RNA Sequencing Analyses Reveal Lactate Metabolism as a Key Pathway in COVID-19-Induced Pulmonary Fibrosis.
Imperatorin Alleviates Intestinal Fibrosis by Suppressing AIM2-mediated GSDMD Pyroptosis in Macrophages.
Platelet-Rich Plasma Attenuates Knee Osteoarthritis in Rats via Modulation of Gut Microbiota.
Berberine Ameliorates Diabetic Kidney Disease by Modulating Macrophage Polarization via Inhibiting IL-17A Signaling.
FGF7-FGFR2 Signaling Enhances Contractile Activation of CAFs in Ovarian Cancer: Integrative Single-Cell and Spatial Transcriptomics.
The mTOR Inhibitor Rapamycin Attenuates Ozone-Induced Airway Inflammation and Emphysema In Mice.
PLA-THF-PEG nanoparticles Co-encapsulating AV3 and KH3 for synergistic pancreatic cancer therapy via stromal remodeling and metabolic inhibition.
Luteolin mitigates proliferative vitreoretinopathy through inhibition of ERK1/2 signaling and epithelial-mesenchymal transition.
Stem cell therapy targets THBS1 to reverse endometrial fibrosis.
An astragalus polysaccharide-loaded hydrogel dressing enhances diabetic wound healing via dual-mode electrical stimulation.
Elevated lactate production exacerbates PM2.5-induced pulmonary fibrosis by stabilizing TGF-β1.
Ginsenoside Rg1 Improves Cardiac Function and Ventricular Remodelling by Down-Regulating SH2B Adaptor Protein 1 Expression in Rats With Myocardial Infarction.
RNF220 mediates K63-linked polyubiquitination of STAT3 and aggravates pathological cardiac hypertrophy.
Long non‑coding RNA NKILA regulates the JAK2/STAT3 pathway to exacerbate TGF‑β1‑mediated renal fibrosis.
Acox1 induces lipid peroxidation and metabolic shifting to promote PASMCs proliferation in hypoxia-induced pulmonary hypertension.
BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer-Associated Fibroblasts Crosstalk.
Effect of TGFβ-ITGB6 feedback loop on liver metastasis in SMAD4 wild-type pancreatic cancer.
Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition.
Study on the anti-pulmonary fibrosis mechanism of Renshen Pingfei formula by inhibiting M2 macrophage polarization and regulating TGF - β/SMAD signaling pathway.
Sodium hyaluronate based multifunctional hydrogels delivering SiRNA for sustained silencing of SMAD3: A novel strategy to treat intrauterine adhesions.
Decoding the DKK1/CKAP4 signaling Axis: A novel mechanism driving Neointimal hyperplasia in arteriovenous fistulas.
N-acetylglucosamine ameliorates the transition from acute kidney injury to chronic kidney disease by reducing the accumulation of lipid droplets.
Danlong oral liquid alleviates airway remodeling in asthma by targeting the S1PR2/ROCK1/YAP signaling pathway in airway smooth muscle cells.
Xuefu Zhuyu decoction attenuates thoracic aortic dissection by regulating VSMC phenotypic switching and oxidative stress via the JAK2/STAT3/HIF-1α pathway.
Early CD201-high cancer-associated fibroblasts shape immunosuppression and suggest a therapeutic opportunity in triple-negative breast cancer.
Puerarin suppress adipogenesis and inflammation on orbital fibroblasts from patients with thyroid eye disease.
RNA-seq and ChIP-seq reveal microplastics induce endothelial-mesenchymal transition via HK2-mediated histone lactylation in pulmonary hypertension.
Coenzyme Q10 Mitigates Myocardial Infarction by Modulating HDAC4 O-GlcNAcylation.
Identification and Validation of MTFP1 as a Mitochondrial Target Restoring Dynamics and ECM Remodeling in Acute Myocardial Infarction.
The m(5)C demethylase TET1 is identified as a key regulator of scleral remodeling in myopia.
Tubular Epithelia-Specific Deletion of MCP-1 Does Not Afford Protection Against Adriamycin-Induced Kidney Injury.
Plasma-activated hydrogel promotes postoperative colonic anastomotic leak healing.
Inhalable lipid nanoparticles for macrophage-specific STING gene editing to ameliorate pulmonary fibrosis.
Network medicine modeling of the m⁶A regulatory landscape identifies a KLF6-WTAP axis as a therapeutic target in pulmonary fibrosis.
TWIST1-Mediated Induction of AEBP1 in Fibroblast-Like Synoviocytes Activates Transforming Growth Factor β Signaling to Drive Angiogenesis and Promote Rheumatoid Arthritis.
Shikonin alleviates high-fat diet-induced vascular aging and dysfunction by inhibiting oxidative stress and mitochondrial damage.
Multifunctional NIR-Responsive Composite Hydrogel with Combinatorial Antibacterial and Regenerative Properties for Diabetic Wound Healing.
Tailored Porous Bimetallic Nanozyme Platform for Full-Cycle Therapeutics of Intestinal Ischemia/Reperfusion.
Ginsenoside Rb1 alleviates endothelial dysfunction and vascular remodeling in preeclampsia via activation of the PI3K-Akt-eNOS pathway.
Sexual dimorphism in keratoconus: transcriptomic and hormonal mechanisms underlying stromal remodelling.
Platelet-rich plasma ameliorates knee osteoarthritis in rats by modulating the abundance of gut Lactobacillus murinus.
Piezo-herbal microneedle patches enable wireless endometrial regeneration and fertility recovery.
The potential impact of exosomal miR-484 on post-myocardial infarction angiogenesis using bioinformatics and experimental verification.
YBX1 promotes angiogenesis after myocardial infarction by stabilizing HIF1α mRNA via m(6)A signaling.
Tannic Acid Achieves Rapid Scar-Free Corneal Healing by Chelating Excess Copper to Suppress Aberrant LOX-Mediated Fibrosis.
Engineering NIR-II carbon dots through aniline extension with graphene and nitrogen enrichment for hepatobiliary theranostics.
Omics insights into MYBL2-promoted cancer stem-like cells driving ferroptosis resistance in hepatocellular carcinoma.
AG1295 Attenuates High-Glucose-Induced Proliferation, Migration, Phenotype Transition, and Interleukin-6 Expression in Human Corneal Stromal Fibroblasts.
A core-shell microneedle platform for the spatiotemporal codelivery of dual-agent therapeutics precisely orchestrates diabetic wound healing.
GDF15-Treated iPSC-MSC-Derived Exosomes Alleviate Fibrosis Post-Myocardial Infarction via Repression of the MFAP4/ERK/Drp1 Axis.
Renal Tubule-Specific Deletion of Nephrocystin 3 (Nphp3) Causes Infantile Nephronophthisis-like Phenotypes in Mice.
A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation-Dependent Cell Adhesion.
Integrative study reveals NR1D1 mediates Hedyotis diffusa's antifibrosis via hypoxia inducible factor-1/ammonia axis.
A β-Glycine-Enhanced Poly(l-lactic acid) Biopiezoelectric Patch for Self-Powered Myocardial Infarction Therapy.
Dynamically responsive hydrogel with mechanical stimulation enhances diabetic wound healing via activation of Piezo1-mediated efferocytosis.
Extracellular vesicle-mediated transcellular mitophagy as a modulatory target for moderate hyperoxia-induced alveolar developmental arrest in bronchopulmonary dysplasia.
Atractylenolide I ameliorates acute-on-chronic liver failure (ACLF) by promoting autophagy and preserving mitochondrial function through mTOR inhibition.
Xueshuantong injection alleviates ischemic heart failure via targeting PFKP-mediated endothelial-to-mesenchymal transition.
Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney fibrosis via the L-carnitine-SIRT3 axis.
SiO(2) dust induces the transformation of lung fibroblasts to myofibroblasts by activating the S1P-RhoA-YAP signaling pathway.
Xiaoyaosan ameliorates stress-induced MASH via modulating IL-1R1/RXRα-mediated liver-brain crosstalk.
Hyaluronic acid-based reactive oxygen species responsive nanocomposite hydrogel for sequential drug delivery and effective prevention of postoperative abdominal adhesions.
The immunomodulatory metabolite butyrate ameliorates renal fibrosis by restoring gut barrier integrity and suppressing the TGF-β1/Smad3 pathway.
Silk fibroin nanofibers-GelMA hydrogel composite loaded with embryonic fibroblasts: A strategy for enhanced wound healing.
DECR1 deficiency activates a lipid peroxidation-mitocytosis-mitochondrial dysfunction axis in trophoblasts to promote preeclampsia.
Endothelial Foxp1 overexpression inhibits endothelial-to-mesenchymal transition via suppressing Notch pathway activation to attenuate valvular calcification in chronic kidney disease.
SSD: Targeting inflammasome and oxidative stress as a therapeutic strategy in inflammatory diseases.
Curdione alleviates renal fibrosis through Fblim1-dependent inhibition of the TGF-β1/Smad3 signaling pathway.
FOXC2 regulates CYP1B1 transcription and activates the TGF-β/Smad pathway to promote pulmonary fibrosis.
The role of the IL-33/ST2/MAPK signalling pathway in macrophage polarisation and endometrial fibrosis.
From inhalation to systemic damage: Decoding the mechanistic cascade of silica nanoparticle-induced multi-organ toxicity.
ND-630, an acetyl-CoA carboxylase inhibitor, prevents renal fibrosis in adenine-induced CKD mice.
Microenvironment-activatable nanoagent for real-time NIR-II monitoring and targeted therapy of arterial restenosis.
Metabolic and epigenetic abnormalities cause hepatic fibrogenesis in metabolic dysfunction-associated steatohepatitis model mice.
ACLP promotes hypertrophic scar pathogenesis by enhancing myofibroblast activation and cholesterol synthesis-related gene expression.
Fe-Mn-IGF-AMD nanoparticles in accurate detection and treatment of liver cirrhosis via regulating relaxation coefficients and attenuating hepatocyte senescence.
QiShenYiQi dripping pills ameliorate post-myocardial infarction cardiac fibrosis via modulation of the cAMP/Rap1 and PI3K/Akt signaling pathways.
Yujie recipe attenuates bleomycin-induced pulmonary fibrosis via suppressing NF-κB/NLRP3 signaling in a Nrf2-dependent manner.
Chronic PET-Microplastic Exposure: Disruption of Gut-Liver Homeostasis and Risk of Hepatic Steatosis.
SLC22A17 affects the development of urethral stricture by promoting ferroptosis and inhibiting the activation of fibroblasts.
Mesenchymal stromal cells ameliorate systemic sclerosis-interstitial lung disease via PD-1/PD-L1 signalling axis.
Mechanistic insights into miR-4775-mediated regulation of pancreatic cancer cell invasion and migration through BRMS1L.
Integrative multiomics analysis reveals the ameliorative effects of Xiasangju on metabolic dysfunction-associated steatohepatitis.
Ganoderma leucocontextum ethanol extract alleviates silica-induced pulmonary injury via TGF-β1/RUNX3/SMADs pathway.
Artemisinin-hydroxychloroquine combination from traditional antimalarial medicine attenuates pulmonary fibrosis via PI3K/AKT/GSK3β-mediated inhibition of epithelial-mesenchymal transition.
Design of RGD-functionalized GSH-responsive pegylated polymeric protacs for selective BRD4 degradation and EndMT-driven cardiac fibrosis inhibition.
Activation of PBK by Gal-3 contributes to pulmonary artery hypertension by promoting PRC1 activation.
Tanshinone IIA accelerates diabetic wound healing via suppression of macrophage NLRP3 inflammasome activity.
Mechanistic Evaluation of Roxadustat for Pulmonary Fibrosis: Integrating Network Pharmacology, Transcriptomics, and Experimental Validation.
PARP1 stabilizes FOXN3 to suppress pulmonary fibrosis through p38-related feedback regulation.
IL-36 participated in airway remodeling in chronic asthma model by inducing epithelial-mesenchymal transition process.
Targeting sorting nexin 3 to treat pulmonary fibrosis by dual modulating Wnt/β-catenin signaling.
Ecliptasaponin A alleviates inflammation and fibrosis in experimental MASH mice via targeting the NLRP3 inflammasome and YAP signaling pathway.
Cuproptosis of bronchial epithelial cells triggers airway remodeling in chronic asthma.
Interorganelle competition for linoleic acid underlies steatotic liver pathology.
Huashi Baidu granules alleviates LPS-induced acute lung injury by targeting TACE-mediated inflammatory signaling and stress granules disassembly.
Guiqi Yishen granule alleviates obstructive nephropathy-induced renal fibrosis by targeting PI3K/AKT signaling pathway.
Potential regulators and metabolic networks of muscle fatty infiltration: genomic and radiomics investigation based on 33 300 participants.
Melatonin alleviates cholestatic liver injury through modulating gut microbiota and activating the NRF2/HO-1 antioxidant pathway.
Mechanism of Curcumin in the Treatment of Intrauterine Adhesions Based on Network Pharmacology, Molecular docking, and Experimental Validation.
Shionone ameliorates pulmonary fibrosis by activating mitophagy via PINK1-Parkin pathway.
BMP1 inhibitor UK383367 improves MI-induced cardiac remodeling and fibrosis in mice via ameliorating macrophage polarization and mitochondrial dysfunction.
Genistein Ameliorates the Ischemic State of Random Skin Flap by Regulating Macrophage Polarization Through AMPK/SIRT1 Signaling Pathway.
Targeting single-cell multiomics-identified vascular impairment: Panax notoginseng extracellular vesicles-loaded adhesive QBK-2/EVs promotes angiogenesis in diabetic wound healing.
Modulation of endothelial-to-mesenchymal transition via NRP-1 targeting with melittin attenuates pulmonary fibrosis.
Depletion of FOXO4 promotes the development of nonalcoholic fatty liver disease by aggravating high-fat diet-induced liver injury by increasing SPP1 expression.
Engineered probiotics for the in vivo mitigation of waterborne uranium toxicity and bioaccumulation.
L-tetrahydropalmatine attenuates methamphetamine-induced pulmonary vascular remodeling via CaSR-BMP2/mTOR signaling.
Engineered Gadolinium-Decorated Magnetic Resonance Nanoprobes for Enhanced Liver Fibrosis Theranostics.
Bioresponsive Nar-Zn@GelMA Hydrogel Reprograms the Diabetic Wound Microenvironment via Antioxidant and Immunoregulatory Synergy.
siRASA1 in vascular endothelial cells alleviates subretinal fibrosis through inhibiting macrophage-myofibroblast transdifferentiation via SHH signaling pathway.
DOT1L promotes phenotypic transition of vascular smooth muscle cells following vascular injury in diabetes through activation of the FGFR4/PI3K/AKT/Jag/Notch signaling pathway.
Autocrine Netrin-1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet-Induced Metabolic Dysfunction-Associated Steatohepatitis in Mice.
Activating the Osteoblastic USP26 Pathway Alleviates Multi-Organ Fibrosis by Decreasing Insulin Resistance.
Construction of a Novel Mucin/Tannic Acid Hydrogel for Diabetic Wound Repair.
Discovery of novel small molecule inhibitor targeting the tumor promoting effect of transcription factor PLAGL2.
Treadmill running modulates infrapatellar fat pad remodeling in osteoarthritic rats in an intensity-dependent manner.
Integrated metabolomics and 16S rRNA sequencing reveal the mechanism of total flavones of Abelmoschus manihot (L.) Medic against liver fibrosis.
Uncovering a Glaucoma-Linked Lysophosphatidic Acid-MAPK/AP-1 Fibrosis Axis in Human Trabecular Meshwork Cells and Its Modulation by Diospyros kaki Leaf Extract.
Exosomal microRNAs of tuberculous pleural effusion orchestrating TGF-β signaling mediate pleural fibrosis.
Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease.
Fibroblast Growth Factor 11 Improves Fertility by Alleviating Intrauterine Adhesionss in Rats Through Inhibition of the Transforming Growth Factor-β1/Smad Pathway.
Targeted inhibition of RGS19 alleviates renal fibrosis by restoring autophagy and modulating immune cell infiltration.
Role of CTGF-LRP1 in impaired healing of cesarean section incisions.
Hydroxytyrosol Prevents Metabolic-Associated Steatohepatitis by Inhibiting SOCS2-Mediated Ferroptosis in High-Fat Diet Mice.
Cancer-Associated fibroblasts regulate the development of cholangiocarcinoma through IL-6/STAT3/AKR1C3 signaling axis.
Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome.
Exosomes derived from bone marrow mesenchymal stem cells facilitate repair of radiation-Induced skin injury by attenuating inflammation and apoptosis.
STING deficiency alleviates scar formation after glaucoma filtration surgery by suppressing p38 MAPK-induced inflammation in mice.
LAPTM5 potentiates airway remodeling by regulating MAPKs-mediated airway smooth muscle cells' dysfunction.
Ultraviolet-induced Glycyrrhiza polysaccharide hydrogels with different mechanical strength for wound management.
Formononetin inhibits p53 signaling pathway activation to delay cellular senescence and ameliorates diabetic kidney disease.
FKBP10 as a prognostic biomarker and therapeutic target in hepatocellular carcinoma.
The Ets2 super-enhancer modulates endothelial-mesenchymal transition during cardiac ageing.
An immunomodulatory hydrogel featuring antibacterial and ROS-scavenging functions for enhanced burn wound healing.
Metamorphosing macrophages promote placental fibrosis by upregulating the transcription factor STAT5A.
Cadmium exposure induces renal fibrosis by inhibiting hsa_circ_0075684/miR-363-3p/KLF4 signaling pathway.
Gingerenone A ameliorates airway inflammation and remodeling in asthma by modulating the TLR4/MyD88/NF-κB pathway.
Identification and validation of the protective gene BCAT2 related to amino acid metabolism in idiopathic pulmonary fibrosis.
Integration of Multi-Omics and Machine Learning Identifies TGFB1 and SERPINE1 as Biomarkers of Vascular Smooth Muscle Cell Senescence in Intracranial Aneurysms.
Structural characterization and anti-hepatic fibrosis effects of a novel polysaccharide from Astragalus complanatus seeds.
Melittin-loaded solid lipid nanoparticles inhibit pulmonary fibrosis via the NOVA2-TGF-β/Smads signaling pathway.
Phosphoglucose isomerase directs the inflammatory response, calcium influx and fibroblast migration in keloids.
Targeting VEGFR2 inhibition within a spatially-confined conduit promotes nerve self-resolution and alleviates mechanical allodynia.
Fosb promotes ferroptosis in vascular smooth muscle cells via the NF-κB pathway to exacerbate abdominal aortic aneurysm progression.
The pro-cancer and immunosuppressive activity of macrophage-transformed cancer-associated fibroblasts in oral squamous cell carcinoma.
Mechanism of Cancer-Associated Fibroblasts-Derived NEAT1 Promoting Pancreatic Cancer Cell Stemness via the miR-101-3p/KDM3A Axis.
Hypoxia Imaging in Hepatic Fibrosis: A Preliminary Application of CAIX-Targeted MRI Probe in Rats.
Spatiotemporal piezoelectric microspheres for wireless endometrial repair with improved pregnancy outcomes.
Injectable Zn(2+)-Driven carrier-free hydrogel via self-assembly of natural small molecules for liver fibrosis therapy through concurrent autophagy activation and ferroptosis inhibition.
An inducible and podocyte-specific diphtheria toxin receptor knock-in mouse model for studying glomerular injury and chronic kidney disease progression.
Biomimetic 3D-printed bilayered scaffold with stem cell delivery for rabbit vaginal regeneration.
Targeting PFKFB3-dependent endothelial-mesenchymal transition by luteolin attenuates doxorubicin-induced cardiotoxicity.
Inhibitory effect of Anwulignan on the IL-36R/TLR9 signaling pathway: potential therapeutic role in hepatic fibrosis.
Flexible Bioactive Glass-Fiber-Reinforced Recombinant Collagen Sponge for Versatile Hemostasis, Antibacterial Protection, and Functional Skin Regeneration.
Protective Effects of Agrimonia pilosa Ledeb. In Myocardial Fibrosis: Inhibition of Mitophagy Mediated by the FOXO Signaling Pathway.
The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis.
SIRT1-regulated mitophagy mitigates lipotoxicity-induced ferroptosis in diabetic kidney disease.
UCHL3 Promotes Triple-Negative Breast Cancer Metastatic Potential Through Enhancing Cell Migration and Invasion.
Mechanisms of Mechanical Stress-Induced Vascular Remodeling via the Lactate-PKM2 Axis and Implications for Microgravity Adaptation.
Therapeutic effects of IL-33/ST-2 pathway inhibition combined with albendazole on hepatic fibrosis and immune regulation in alveolar echinococcosis: in vivo and in vitro evidence.
Emerging Alternaria Toxins Drive LX-2 Cells Transdifferentiation into Myofibroblasts for Liver Fibrosis and CotA Detoxification.
USP10 from Human Umbilical Cord Mesenchymal Stem Cells-Derived Extracellular Vesicles Mediates SCL7A11 Deubiquitination in Epithelial Cells: A Key to Anti-ferroptosis and Anti-fibrosis in Pulmonary Fibrosis.
Subamnex Ameliorates Hypoxia-Induced Pulmonary Arterial Hypertension through Modulation of the STAT3/p-STAT3 Pathway.
DECR1 degradation by ursolic acid alleviates vascular calcification through inhibition of NF-κB/NLRP3 signaling pathway.
Knockdown of METTL3 ameliorated myofibroblast activities in oral submucous fibrosis through upregulating DKK3.
TKT inhibition attenuates cardiac fibrosis in myocardial infarction through deactivating AKT signaling pathway.
Triggering Receptor Expressed on Myeloid Cells-2 Regulates Innate Lymphoid Cell Levels in Bleomycin-Induced Pulmonary Fibrosis.
Targeting keratin 6 A overcomes gemcitabine resistance by restoring equilibrative nucleoside transporter 1 and TAM-mediated metabolic compensation in pancreatic cancer.
Mammary organoid-based depot for post-surgical chemotherapy and gland regeneration.
Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates diabetic nephropathy via suppressing SLC7A11-mediated ferroptosis.
IL-5 promotes airway remodeling in asthma by mediating epithelial-mesenchymal transition via the AKT/NLRP3 pathway.
Vericiguat improves CKD-related vascular calcification through the NO/cGMP/PKG pathway.
Cardiac reprogramming via transient overexpression of P-glycoprotein alleviates doxorubicin-induced cardiotoxicity in mice and pigs.
Dissolvable Microneedle Arrays Loaded with SCH772984 Targeting the MAPK/ERK Pathway to Inhibit Abnormal Vascular Proliferation in Hypertrophic Scars.
Beryllium Sulfate-Induced Cellular Senescence via the IL-6/STAT3 Pathway to Promote Pulmonary Fibrosis.
VHL-recruiting PROTAC attenuates AKI-CKD transition via simultaneous degradation of Smad3 and stabilization of HIF-2α.
Integrative metabolomics and lipidomics reveal Jian-Pi-Yi-Shen formula improves adenine-induced CKD rats by regulating intrarenal glycolipid metabolism.
Increased PRSS56 expression is a causal factor and therapeutic target for human axial high myopia.
Store-operated Ca(2+) entry contributes to the ASM phenotype transition in asthma.
HE4 Might Participate in Extracellular Matrix Remodeling in Ovarian Cancer via Activation of Fibroblasts.
Targeting Smad3 Phosphorylation Attenuates Anastomotic Intimal Hyperplasia and Perigraft Fibrosis in Decellularized Tissue-Engineered Vascular Grafts.
Perfluorocarbon Nanoparticles Loaded with Oxygen Alleviate Acute Kidney Injury via Ameliorating Renal Oxygenation Level.
Integrated transcriptome and proteome analysis identifies keratins as key regulators of corneal scarring in a murine model.
Mechanisms of AGE-induced VSMC phenotypic switching and macrophage modulation in human abdominal aortic aneurysms.
GDF10 attenuates MASH progression by restoring quiescent hepatic stellate cells via competitive inhibition of TGF-β/SMAD2 signaling.
Mechanical stretch-induced IGF2 overexpression in epidermal keratinocytes promotes hypertrophic scar formation through the IGF1R/p-c-Jun axis.
Expression Profile of Urinary Exosomal miRNAs in Patients With Diabetic Kidney Disease and Their Association With Kidney Damage.
Targeting interferon-stimulated gene of 20 kDa protein (Isg20) inhibits ribosome biogenesis to ameliorate the progression of renal fibrosis.
Inhibition of PHB1/PHB2 suppresses atherosclerotic plaque formation by interrupting PI3K/AKT/mTOR signaling.
Plasma-activated media inhibits epithelial-mesenchymal transition and ameliorates intestinal fibrosis through the PPARγ/TGF-β1/SMAD3 pathway.
NIR-II Imaging Guided Accurate Identification of Paraspinal Muscle Degeneration Through Targeting the Lysosomal Membrane Protein Sidt2.
TFR1 as a Biomarker of Pulmonary Fibrosis Development in COPD Patients.
Enhanced Antitumor Efficacy and Reduced Toxicity in Colorectal Cancer Using a Novel Multifunctional Rg3- Targeting Nanosystem Encapsulated with Oxaliplatin and Calcium Peroxide.
Liu Wei Di Huang Decoction Alleviates Renal Fibrosis by Inhibiting Endothelial Mesenchymal Transitions via Upregulating Sirt1 Expression and Inhibiting the Wnt/β-Catenin Signaling Pathway.
ShenQi ShenKang Granule Alleviates Chronic Kidney Disease by Inhibiting the PI3K/AKT/mTOR Pathway and Restoring Autophagy Flux and Mitochondrial Integrity.
Mechanism of the Traditional Chinese Medicine Simiao Biejia Decoction Improves the Diabetes Mellitus-Induced Erectile Dysfunction in Rats.
PLK1 Mediates the Proliferation and Contraction of Airway Smooth Muscle Cells and Has a Role in T2-High Asthma with Neutrophilic Inflammation Model.
Rapamycin and Chloroquine Modulate Insulin Resistance and Hepatic Steatosis in a High-Fat/High-Cholesterol Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Mouse Model.
SIRT1 Enhancement is Required for the Induction of Anti-Inflammatory Effect of Micheliolide in Carbon Tetrachloride Induced Liver Fibrosis in Mice.
Cannabidiol Alleviates Intestinal Fibrosis in Mice with Ulcerative Colitis by Regulating Transforming Growth Factor Signaling Pathway.
Aldose Reductase Mediated Mitophagy Promotes Epithelial-Mesenchymal Transition of Hepatocytes.
Multi-Omics Analysis Reveals the transforming growth factor-β Signaling-Driven Multicellular Interactions with Prognostic Relevance in Cervical Cancer Progression.
Quercetin ameliorates renal injury in hyperuricemic rats via modulating ER stress pathways.
Targeted ferroptosis of myofibroblasts by tubeimoside I attenuates hypertrophic scar formation.
Targeting macrophage-myofibroblast transition with Caulis spatholobi to attenuate renal interstitial fibrosis: integrated UHPLC-Q-Exactive Orbitrap-MS, network pharmacology, and experimental validation.
Identify GDPD3 as a key regulator of epithelial-mesenchymal transition and prostate adenocarcinoma progression via the LPA/LPAR1/AKT axis: transcriptomic and experimental study.
Identifying potential drugs for treating Cardiovascular-kidney metabolic syndrome via reverse network pharmacology.
Loss of p21 does not protect against premature ovarian insufficiency caused by alkylating agents.
Quercetin ameliorates epithelial-mesenchymal transition and inflammation by targeting FSTL1 and modulating the NF-κB pathway in pulmonary fibrosis.
Lactobacillus rhamnosus GG attenuates MASLD/MASH progression by modulating gut microbiota and metabolic pathways.
Programmed cell death-related prognostic genes mediate dysregulation of the immune microenvironment in triple-negative breast cancer.
Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation.
Serum chemokines combined with multi-modal imaging to evaluate atherosclerotic plaque stability in patients undergoing carotid endarterectomy.
Role of integrin α4 in the inhibition of fibrosis in activated hepatic stellate cells by Periplaneta americana extract.
MgSO(4) as a novel hypothermia infusion solution promotes ischemic stroke recovery through Ca(2+) regulation of neurovascular units.
A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY.
Ivermectin attenuates Schistosoma japonicum-induced liver fibrosis and is associated with downregulation of YAP signaling.
The Effects of M2 Macrophages-Derived Exosomes on Urethral Fibrosis and Stricture in Scar Formation.
IGF1R promotes radiation-induced HSCs activation by regulating DNA-PKcs-mediated DNA damage repair.
Deciphering the tumor ecosystem dynamics undergoing immunochemotherapy therapy across multiple cancer types unveils the immunosuppressive role of S100A4 in fibroblasts by promoting PD-L1 expression in tumor cells.
Saliva-derived exosomes regulate fibroblast metabolic reprogramming in skin wound healing.
Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice.
Injury and cyclic stretch induce vein graft failure: effective treatment with zinc oxide-loaded electrospun polycaprolactone external stent.
Rhodiola rosea-derived exosome-like nanovesicles inhibit vascular endothelial pyroptosis in the treatment of limb skeletal muscle ischemic injury through the TXNIP/NLNP3 pathway.
Glutamate enhances the production of inflammatory cytokines IL-6 and IL-11, as well as chemokines CXCL2, CXCL3, and CXCL8 in keloid fibroblasts.
The endogenous glutamatergic transmitter system promotes collagen synthesis in cardiac fibroblasts under hypoxia.
Ascorbic acid deficiency promotes metabolic remodeling and pulmonary fibrosis that leads to respiratory failure in Sod1 and Akr1a double-knockout mice.
The Paeonol of Total Glucosides of White Peony Regulates the Differentiation of CD4+Treg Cells through the EP300/Foxp3 Axis to Relieve Pulmonary Fibrosis in Mice.
Suyin Detoxification Prescription Regulates the Klotho and ERK/NF-κB Signaling Pathways to Alleviate Renal Injury.
Diosmetin alleviates osteoarthritis through modulating the polarization of macrophages by inhibiting the PI3K/Akt signaling pathway.
Sustained oxygen-releasing hydrogel implants enhance flap regeneration by promoting mitochondrial biogenesis under mild hypoxia.
Dl-3-n-butylphthalide attenuates acute myocardial infarction by inhibiting the binding of Nrf2/Keap1.
miR-210-3p Ameliorates Metabolic Dysfunction-Associated Steatohepatitis-Related Fibrosis by Targeting ISCU and Induces Ferroptosis.
METTL3 Mediates Wnt/β-Catenin Pathway in Epithelial-Mesenchymal Transition of 16HBE Cells Induced by Beryllium Sulphate.
Leukemia Inhibitory Factor via JAK-STAT Signaling Drives Beryllium Sulfate-Induced Epithelial-Mesenchymal Transition in 16HBE Cells.
Recombinant chromosome 6 open reading frame 120 protein promotes angiogenesis and endothelial‑to‑mesenchymal transition in human umbilical vein endothelial cells via the PI3K/Akt signaling pathway.
Novel partial common bile duct ligation procedure in rats with reduced mortality and delayed onset of cirrhosis.
METTL3 Silencing Suppresses Cardiac Fibrosis Post Myocardial Infarction via m6A Modification of SMOC2.
KLF3 aggravates renal fibrosis in chronic kidney disease through transcriptional activation of DDAH2.
IFITM1 promotes proliferation, migration and macrophage-like transdifferentiation of vascular smooth muscle cells via c-Src/MAPK/GATA2/E2F2 pathway in atherosclerosis.
Mito-tempo ameliorates tubular injury of diabetic nephropathy via inhibiting mt-dsRNA release and PKR/eIF2α pathway activation.
Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients and Mice with Wilson Disease.
The chemokine CCL20 promotes hepatocyte cholesterol deposition during metabolic dysfunction-associated steatohepatitis by regulating OLR1 expression.
Shenling Tongqiao powder targets TGF-β1/Smad-Wnt/β-catenin axis to suppress epithelial-mesenchymal transition in chronic rhinosinusitis.
Multi-omics analysis of the active components and mechanisms of Baojin Chenfei formula in silica-induced murine silicosis.
Cancer Cell-Secreted miR-33a Reduces Stress Granule Formation by Targeting Polyamine Metabolism in Stroma to Promote Tumourigenesis.
PINK1 deficiency alleviates bleomycin-induced pulmonary fibrosis in mice.
The role of APOBEC mutagenesis in the progression and therapeutic guidance of pancreatic cancer.
5-Aminolevulinic acid-mediated photodynamic therapy improves scar healing of laryngeal wounds in rats.
Comparative analysis of commercial human primary mesangial cell, implications for experimental design.
MiR-7683-3p from M2-exosomes attenuated atherosclerosis by activating the PPARγ-LXRα-ABCG1 pathway mediated cholesterol efflux of vascular smooth muscle cell derived foam cells.
Morphological and histopathological study of edible bird's nest on wound healing in mice.
Mechanism of Bao Gan Ning decoction in attenuating hepatic fibrosis via modulation of the gut microbiome and PPAR/CYP7A1-mediated bile acid metabolism.
Danggui Buxue Decoction inhibits pulmonary fibrosis by alleviating TGF-β1-induced proliferation and apoptosis in EBL cells via PI3K/AKT/FOXO1 pathway.
Yishen Qufeng formula mediates ferroptosis to improve renal fibrosis in unilateral ureteral obstruction rats.
Kaempferol improves mitochondrial homeostasis via mitochondrial dynamics and mitophagy in diabetic kidney disease.
Caffeic acid mitigates restenosis post-angioplasty via oxidative stress and inflammation reduction and mitochondrial protection in vascular smooth muscle cells.
Unraveling the therapeutic mechanisms of Bufei Yiqi decoction in pulmonary fibrosis: Modulation of autophagy and glycolysis pathways.
Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.
Therapeutic potential of Desmodium styracifolium polysaccharide in attenuating nano-calcium oxalate induced renal injury and fibrosis.
LINC02099 Promotes Retinal Extracellular Matrix Deposition in Diabetic Mice Via the miRNA-214-3p/CTSS Axis.
A novel chronic hepatitis B mouse model with immune activation and liver fibrosis.
Role of NLRP3 in the metabolism of bile acids and gut microbiota in CCl4-induced liver fibrosis.
Pancreatic stellate cells promote pancreatic regeneration in chronic pancreatitis via exosomal lncRNA MALAT1-Induced acinar-ductal metaplasia.
Single-Cell Transcriptomics of Human Pericarotid Lymph Nodes Indicating Stability of Carotid Atherosclerotic Plaques.
Bruceine D inhibits CAF-promoted angiogenesis of breast cancer via suppressing IL-6-mediated activation of the STAT3/Notch1/VEGFR2 axis.
Menaquinone-4 inhibits the formation and vulnerability of atherosclerotic plaques in apolipoprotein E knockout mice by decreasing the uptake of the oxidized low-density lipoprotein in macrophages.
Lithospermic acid improves diabetic kidney fibrosis by regulating Piezo1/TGF-β1/Smad signaling pathway.
Inhibition of GRK2 mitigates renal fibrosis via oxidative stress pathway.
Adipose-derived stem cell therapy restores erectile function and promotes endogenous stem cell recruitment in a rat model of cavernous nerve injury.
Rosmarinic acid confers beneficial effects by specifically activating PRDX1 peroxidase activity.
Apigenin inhibits endothelial-to-mesenchymal transition of coronary artery endothelial cells and myocardial fibrosis by regulating ribosome biogenesis through GTPBP4 modulation.
Urolithin C Ameliorates Hyperuricemia by Mitigating Renal Dysfunction through ROS-p38/ERK MAPK Axis Suppression.
Cancer-associated fibroblast-derived extracellular vesicles loaded with GLUT1 inhibitor synergize anti-PD-L1 to suppress tumor growth via degrading matrix stiffness and remodeling tumor microenvironment.
Targeting Ferroptosis Alleviates Pulmonary Arterial Hypertension, Insights from Transcriptomic and Experimental Analyses.
RNF213 Knockdown and Inflammation Promote Angiogenesis and Phenotype Switching by JAK2/STAT3 Pathway in Moyamoya Disease.
Disruption of Bile Acid Metabolism in the Gut-Liver Axis Predisposes Mice to Inflammatory Bowel Disease.
Ellagic Acid-Loaded sEVs Encapsulated in GelMA Hydrogel Accelerate Diabetic Wound Healing by Activating EGFR on Skin Repair Cells.
Single-cell multi-omic and spatial profiling of esophageal squamous cell carcinoma reveals the immunosuppressive role of GPR116(+) pericytes in cancer metastasis.
S100A8/9-NLRP3-mediated chronic unresolved inflammation drives cardiac pathologies following invasive pneumococcal disease.
Magnesium ions attenuate tendon graft fibrosis during its ligamentization after ACL reconstruction through modulation of fibroblast to myofibroblast trans-differentiation by promoting PGE2 secretion.
Dapagliflozin ameliorates high glucose-induced epithelial-mesenchymal transition via up-regulating ACE2 mediated by EZH2 in diabetic nephropathy.
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis.
Downregulation of the core circadian gene Nr1d2 in the lacrimal gland contributes to postoperative dry eye disease by impairing lipid metabolism.
FAPI-engineered nanoprobe induces dual-cell ferroptosis therapy and enables light-up magnetic resonance imaging for gastric cancer peritoneal metastasis.
Stepwise targeting hyaluronic acid-based polymeric prodrug for acute kidney injury and prevents its progression to chronic kidney disease.
Oxymatrine attenuates pulmonary fibrosis via APE1‑mediated regulation of the PINK1/Parkin pathway.
Resveratrol glycoside inhibits NLRP3/IL-1β/NF-κB to alleviate peritoneal fibrosis in peritoneal dialysis.
miR-29a-3p participates in the pathogenesis of spontaneous abortion by inhibiting trophoblast function targeting COL4A2/COL5A1.
Peroxisome Proliferator-Activated Receptor Agonist IVA337 Alleviates Inflammation and Fibrosis in MASH by Restoring Lipid Homeostasis.
Histone deacetylase 11 regulates stress granule formation to promote endothelial-to-mesenchymal transition in atherosclerosis.
YY1/INSIG1 enhances atherosclerosis progression by regulating AMPK-mTOR signaling.
Small proline-rich protein 2A drives epithelial remodeling in eosinophilic chronic rhinosinusitis with nasal polyps via SAA2 upregulation.
Rottlerin inhibits PKCδ to attenuate pulmonary fibrosis by suppressing NLRC4/ASC-mediated pyroptosis.
Capsaicin ameliorates cholestasis through modulation of the FXR-SHP and FXR-FGF15 gut-liver axis in mice.
Mori fructus-derived extracellular vesicle-like nanoparticles regulate dyslipidemia and prevent atherosclerosis progression via miRNAs.
Alpha-tocopheryl quinone attenuates liver fibrosis through enriching Christensenella minuta and modulating bile acids metabolism via gut-liver axis.
Identification of lactylation-related hub genes as novel therapeutic and diagnostic targets for thoracic aortic dissection.
TNALP promotes epithelial oxidative stress and fibrosis via SIRT3-dependent mechanisms in tracheal injury.
Aerobic exercise alleviates chronic allergic airway inflammation by regulating the circMETTL9/EIF4A3/IGFBP3 axis.
Triamcinolone Acetonide (TCA)-Loaded Biodegradable Microspheres Improve Therapeutic Outcomes in Thyroid-Associated Ophthalmopathy (TAO) by Reducing Fibrosis and Adipogenesis.
De Novo Discovery of a Macrocyclic Peptide Antagonist of Interleukin-11 with Antirenal Fibrotic Efficacy.
Geniposide alleviates kidney fibrosis by targeting STAT3-HK2-mediated glycolysis.
Liver-Targeted Scutellarin Nanoemulsion Alleviates Fibrosis with Ancillary Modulation of the Gut-Liver Microbiota.
Injectable Immune-Regulating Mesenchymal Stem Cells Hydrogel for Localized Scleroderma Treatment.
Development of a potent BET inhibitor for the treatment of renal fibrosis.
Wuhu decoction regulates ROS/AMPK/mTOR pathway-mediated dendritic cells autophagy and pyroptosis for the treatment of respiratory syncytial virus-induced asthma.
FAM3B activates hepatic stellate cells to accelerate hepatic fibrosis by promoting glucose metabolism.
Anemoside B4 improves cardiac function after myocardial infarction by regulating HTR2A/ERK pathway.
PGRN mediates the crosstalk between ovarian cancer cells and CAFs and reshapes tumor immune microenvironment.
Senkyunolide I targets CXCR4 to attenuate liver fibrosis via suppression of the NLRP3/GSDMD pathway.
Canagliflozin inhibits hepatic stellate cells activation and proliferation by inhibiting PP2A-mediated β-catenin dephosphorylation to attenuate hepatic fibrosis.
MBD2 deficiency attenuates CCl(4)-induced hepatic fibrosis by inhibiting M2 macrophage polarization.
EphrinB2 in dental pulp stem cells promotes endothelial cells forming capillary-like cords in a 3D bioprinted hydrogel construct.
Fusobacterium nucleatum increases CTGF expression through TLR2-YAP signaling axis in cancer-associated fibroblasts, thereby promoting colorectal cancer progression.
Mesenchymal stem cells inhibit mitochondrial fission by upregulating armadillo repeat containing 1, ameliorating oxidative stress in renal fibrosis.
Design and Synthesis of Senescence-Targeted Prodrugs with Senomorphic and Senolytic Properties To Mitigate Chemotherapy-Induced Kidney Injury.
Long-Term Maternal Exposure to Triclosan Provokes Pulmonary Fibrosis in Mouse Offspring.
MIF Promotes Phenotypic Switching of VSMCs via AKT/mTOR-Mediated Autophagy Regulation in Aortic Dissection.
Nephroprotective mechanism of Kunkui Baoshen decoction in diabetic kidney disease: Targeting the HERC2/NCOA4-mediated autophagy-dependent ferroptosis pathway.
Transcription factor MEOX1 accelerates pulmonary fibrosis by regulating mitophagy and senescence.
Albiflorin attenuates post-myocardial infarction cardiac fibrosis through inhibiting the RAS-ERK/MAPK signaling pathway.
Mechanism of silica nanoparticles induced pulmonary epithelial-mesenchymal transition mediated by exosomal HNRNPAB.
Bioinspired Multifunctional Hydrogel Loaded with Netrin-1 for Diabetic Wound Healing.
Faecalibacterium prausnitzii alleviates Graves' orbitopathy by modulating short-chain fatty acid (SCFA) metabolism and inhibiting orbital fibrosis and adipogenesis.
m(6)A deficiency impairs uterine spiral artery remodeling to induce preeclampsia-like symptoms via FGF2.
A contractility-competent immortalized human sweat gland myoepithelial line with dual epithelial-mesenchymal characteristics.
Interleukin 33 Promotes Liver Sinusoidal Endothelial Cell Dysfunction and Hepatic Fibrosis in Diabetic Mice.
Porous chitin nanofibers combined with adipose-derived stem cells promote diabetic wound healing via PPAR-γ activation.
LncRNA LINC01605 Regulates Smooth Muscle Cell Functions and Participates in the Development of Aortic Dissection Through Regulating SGK1.
Asiaticoside and asiatic acid improve diabetic nephropathy by restoring podocyte autophagy and improving gut microbiota dysbiosis.
Aristolochic acid I promotes renal tubulointerstitial fibrosis by activating the mannan-binding lectin serine protease 1-complement system.
An Ile to Met polymorphism in ADCY9 promotes airway obstruction and remodeling in asthma.
Quercetin ameliorates renal injury by promoting UCP1-mediated alleviation of lipid accumulation in diabetic kidney disease.
The total xanthones from Gentianella acuta alleviate acute myocardial infarction by targeting BRD4-mediated cardiomyocyte pyroptosis and inflammation.
Fucoxanthin ameliorates vascular remodeling via attenuating oxidative stress in hypoxic pulmonary hypertension rats.
Self-Assembled Tetrahedral Framework Nucleic Acids Alleviate Pulmonary Hypertension by Regulating Calcium Homeostasis.
Resident Macrophage-Orchestrated Immune and Fibroblast Interactions in Immune Checkpoint Inhibitor-Associated Nephrotoxicity.
A mitochondria-targeted nanomedicine for myocardial ischemia/reperfusion injury with synergistic antioxidant and anti-inflammatory properties.
TGF-β1 mediates epithelial-mesenchymal transition in interstitial cystitis through the regulation of ROCK.
From Gene to Scar: Proteome-Wide Causal Insights into Keloid Pathogenesis and Prevention.
Mfn2 Regulates Scleral Remodeling in Myopia by Maintaining Endoplasmic Reticulum Homeostasis in Scleral Fibroblasts.
Dapagliflozin ameliorates high glucose-induced peritoneal fibrosis through downregulation of ENKUR/PI3K/AKT signaling pathway.
Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway.
CAFs-derived SPI1 in tumor fibroblasts promotes malignant behaviors of liver cancer cells and immune escape by regulating HRAS and PD-L1 transcription.
Extracellular matrix anchored neutrophils drive pulmonary fibrosis in mice.
An integrated study on the role and underlying mechanism of QingFei Oral solution in pulmonary hypertension.
Dynamic remodelling of epithelial plasticity in colorectal cancer from single-cell and spatially resolved perspectives.
The TRPV4-YAP axis mediates cytoskeletal and extracellular matrix remodeling in trabecular meshwork cells as a novel glaucoma mechanism.
HMGA1 drives EMT in obliterative bronchiolitis through epigenetic regulation of chromatin accessibility in pulmonary epithelial cells.
Synergistic promotion of bone regeneration through co-culture of endothelial cells with mesenchymal stem cells in endochondral ossification organoids.
SHP1 overexpression ameliorates renal fibrosis via inhibition of STAT3 signaling and glycolysis reprogramming.
Epigenetic silencing of MSTN via m6A modification underlies the renoprotective effects of engineered MSC exosomes with RBM15 depletion in diabetic nephropathy.
Berberine ameliorates atherosclerosis by inhibiting the phenotypic transition of vascular smooth muscle cells via suppression of the JAK2/STAT3 signaling pathway.
Therapeutic potential of the LUCAT1/miR- 2278/STAT5A axis in pulmonary fibrosis.
Curcumenol exerts anti-pulmonary fibrosis effects through modulation of the immune signature target SPP1: based on comprehensive bioinformatics and experiments validation.
Sotagliflozin attenuates atrial oxidative stress and the susceptibility to atrial fibrillation by activating the NRF2/HO-1 pathway.
AARS1 promotes endometriosis progression by promoting the lactylation of Snail1†.
Comprehensive pan-cancer analysis of USP35 and validation of its role in gastric cancer.
Context-dependent contribution of peptidyl arginine deiminase 4 (PAD4) to neutrophil extracellular trap formation and liver injury in acute and chronic hepatotoxicant challenge.
Targeting PIM1 by Bruceine D attenuates skin fibrosis via myofibroblast ferroptosis.
Tryptanthrin alleviate lung fibrosis via suppression of MAPK/NF-κB and TGF-β1/SMAD signaling pathways in vitro and in vivo.
Ras Guanine Nucleotide-Releasing Protein-4 Inhibits Erythropoietin Production in Diabetic Mice with Kidney Disease by Degrading HIF2A.
Identification of potential mechanisms of Schisandrin B in the treatment of idiopathic pulmonary fibrosis by integrating network pharmacology and experimental validation.
Dihydroartemisinin requires NR1D1 mediated Rab7 ubiquitination to regulate hepatic stellate cells lipophagy in liver fibrosis.
Thrombospondin-1 binds to integrin β3 to inhibit vascular calcification through suppression of NF-κB pathway.
Adipose stem cells ameliorate erectile dysfunction in diabetes mellitus rats by attenuating ferroptosis through NRP1 with SLC7A11 interaction.
A Keap1-recruiting BRD4 degrader offers a single-molecular polypharmacology approach for the treatment of metabolic dysfunction-associated steatohepatitis.
Breaking the synergism of iron overload and miR-122 to rescue lipid accumulation and peroxidation in MASLD.
Porcine plasma protein cold-set hydrogel crosslinked by genipin and the immunomodulatory, proliferation promoting and scar-remodeling in wound healing.
Epithelial-Mesenchymal Plasticity in the D-Meso-Sonobe Mesothelioma Cell Line: A Putative Model of Epithelial-Mesenchymal Transition in Mesothelioma.
GRB2 Promotes Malignant Behaviors of Breast Cancer by Modulating the Global Expression and Alternative Splicing Profiles in SK-BR-3 Cells Through Binding mRNA.
Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia-Induced Vascular Injury.
CILP1 interacting with YBX1 promotes hypertrophic scar formation by suppressing PPARs transcription.
Bladder patch repair using mesothelial Cell-Seeded autologous granulation tissue: an experimental study in male rabbits.
Immunodynamic axis of fibroblast-driven neutrophil infiltration in acute pancreatitis: NF-κB-HIF-1α-CXCL1.
Methyltransferase-like 3-catalysed N6-methyladenosine methylation facilitates the contribution of vascular smooth muscle cells to atherosclerosis.
Pulmonary Injury Induced via Metal-Organic Frameworks (MOFs): ROS Generation and Inflammatory Responses Mediated by HKUST-1.
SMYD2 Promotes Renal Tubular Cell Apoptosis and Chronic Kidney Disease Following Cisplatin Nephrotoxicity.
Gestational Exposure to Phenanthrene Induces Superfluous Fibrosis and Calcification and Metabolic Imbalance of the Placenta in Mice.
Serum-free endothelial cell culture medium for vascular smooth muscle cells sheet formation.
Saliva-derived extracellular vesicles: a promising therapeutic approach for salivary gland fibrosis.
The oncogenic role of TIMM8A in cancer and the mechanistic insights into the function in breast cancer cells.
Hypoxia-inducible factor-1 alpha (HIF-1α) inhibitor AMSP-30 m attenuates CCl(4)-induced liver fibrosis in mice by inhibiting the sonic hedgehog pathway.
Hepatocyte-specific CLSTN3B ablation impairs lipid droplet maturation and alleviates diet-induced steatohepatitis in mice.
Delivery of bone marrow mesenchymal stem cell-derived exosomes into fibroblasts attenuates intestinal fibrosis by weakening its transdifferentiation via the CCN2-TGF-β axis.
Porphyromonas gingivalis aggravates atherosclerotic plaque instability by promoting lipid-laden macrophage necroptosis.
Asb10 accelerates pathological cardiac remodeling by stabilizing HSP70.
LONP1 facilitates pulmonary artery smooth muscle cell glycolytic reprogramming by degrading MPC1 in pulmonary hypertension.
Tetrathiomolybdate alleviates bleomycin-induced pulmonary fibrosis by reducing copper concentration and suppressing EMT.
The integrated single-cell analysis interpret the lactate metabolism-driven immune suppression in triple-negative breast cancer.
Urolithin A enhances diabetic wound healing: Insights from parkin-mediated mitophagy in endothelial progenitor cells.
Astragaloside IV prevents liver fibrosis by blocking glycolysis-mediated macrophage M1 polarization.
Orai1 Participates in Coronary Artery Dysfunction Caused by Hypertension via Regulating Smooth Muscle Cell Phenotype Transformation.
Exploring the wound-healing mechanism of Cayratia japonica extract: A combined experimental and network pharmacology study.
Urolithin B suppresses phenotypic switch in vascular smooth muscle cells induced by PDGF-BB via inhibiting the PI3K-AKT pathway.
Ergothioneine Ameliorates Liver Fibrosis by Inhibiting Glycerophospholipids Metabolism and TGF-β/Smads Signaling Pathway: Based on Metabonomics and Network Pharmacology.
Dihydrotanshinone I Attenuates Diet-Induced Nonalcoholic Fatty Liver Disease via Up-Regulation of IRG1.
Bergapten Ameliorates Renal Fibrosis by Inhibiting Ferroptosis.
Conductive hyaluronic acid/phytanic acid hydrogel to deliver recombinant human amelogenin for diabetic wound repair.
ROS scavenging and corneal epithelial wound healing by a self-crosslinked tissue-adhesive hydrogel based-on dual-functionalized hyaluronic acid.
Kindlin-3 Promotes Angiogenesis via Notch Signalling and Is Crucial for Functional Recovery Postmyocardial Infarction.
Identification of the Hub Gene LDB3 in Stanford Type A Aortic Dissection Based on Comprehensive Bioinformatics Analysis.
p16INK4a Deletion Alleviated Obesity-Associated Kidney Fibrosis by Regulating Metabolic Reprogramming and the Inflammasome Pathway.
Phenylethanol Glycosides from Cistanche tubulosa Modulate the Gut Microbiota and Cecal Metabolites to Ameliorate Diabetic Nephropathy Induced by Streptozotocin Combined with High-Fat Diet in Rats.
Protective Effects of Lactoferrin Treatment Against Sodium Arsenite Exposure-Induced Nephrotoxicity.
Anti-fibrosis effect and its mechanism of atractylenolide III on post-traumatic extending knee joint contracture in rats.
Renal tubular S100A7a impairs fatty acid oxidation and exacerbates renal fibrosis via both intracellular and extracellular pathway.
Exosomes derived from fibroblasts in DFUs delay wound healing by delivering miR-93-5p to target macrophage ATG16L1.
1-benzyl-6-nitro-4-phenyl-4-(methoxycarbonyl)-2(1H)-pyridinone, a novel pirfenidone derivative, alleviate hepatic fibrosis through T cells.
The role of fibromodulin in myocardial fibrosis in a diabetic cardiomyopathy rat model.
Enhanced Vascular Smooth Muscle Cell and Extracellular Matrix Repair Using a Metal-Organic Framework-Based Co-Delivery System for Abdominal Aortic Aneurysm Therapy.
Puerarin mitigates cognitive decline and white matter injury via CD36-Mediated microglial phagocytosis in chronic cerebral hypoperfusion.
Lgals3 Promotes Calcium Oxalate Crystal Formation and Kidney Injury Through Histone Lactylation-Mediated FGFR4 Activation.
4-Octyl Itaconate Alleviates Myocardial Ischemia-Reperfusion Injury Through Promoting Angiogenesis via ERK Signaling Activation.
Mechanism of β-Catenin in Pulmonary Fibrosis Following SARS-CoV-2 Infection.
An annular corneal microneedle patch for minimally invasive ophthalmic drug delivery.
Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution.
Network pharmacology and molecular docking technology-based predictive study and potential targets analysis of icariin for the treatment of diabetic nephropathy.
Reticulophagy promotes EMT-induced fibrosis in offspring's lung tissue after maternal exposure to carbon black nanoparticles during gestation by a m(5)C-dependent manner.
Inhibition of NLRP3 alleviates calcium oxalate crystal-induced renal fibrosis and crystal adhesion.
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex.
KLF5 enhances CXCL12 transcription in adipose-derived stem cells to promote endothelial progenitor cells neovascularization and accelerate diabetic wound healing.
VHL ameliorates arecoline-induced oral submucosal fibrosis by promoting HDAC6 ubiquitination and blocking NF-κB pathway.
Inhibition of HSC proliferation and hepatic fibrogenesis with Erythrocyte membrane coated Doxorubicin/Black phosphorus nanosheets.
Butyrate Ameliorates Graves' Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota.
Cyanidin-3-glucoside upregulated NDRG2 through the PI3K/AKT pathway to alleviate EMT and ECM in renal fibrosis.
Medium from human iPSC-derived primitive macrophages promotes adult cardiomyocyte proliferation and cardiac regeneration.
Electroacupuncture Attenuates Intestinal Barrier Disruption via the α7nAChR-Mediated HO-1/p38 MAPK/NF-κB Pathway in a Mouse Model of Metabolic Dysfunction-Associated Fatty Liver Disease: A Randomized, Single-Blind, Controlled Trial.
Colorectal cancer cells-derived exosomal miR-188-3p promotes liver metastasis by creating a pre-metastatic niche via activation of hepatic stellate cells.
Rare and common genetic variants underlying the risk of Hirschsprung's disease.
Low intensity pulsed ultrasound alleviates synovial fibrosis in osteoarthritis via the PI3K/AKT pathway.
Vitamin A-Integrated Cinnamaldehyde Nanoemulsion: A Nanotherapeutic Approach To Counteract Liver Fibrosis via Gut-Liver Axis Modulation.
Polo-like kinase2 regulates renal tubulointerstitial fibrosis via notch signaling pathway in diabetic kidney disease.
TRPML1 ion channel promotes HepaRG cell differentiation under simulated microgravity conditions.
Silencing hepatic PCSK9 via novel chimeric AAV8 mitigates the progression of atherosclerosis by inhibiting inflammation in ApoE(-/-) mice.
Aerosolized nicotine-free e-liquid base constituents exacerbates mitochondrial dysfunction and endothelial glycocalyx shedding via the AKT/GSK3β-mPTP pathway in lung injury models.
Baicalin reduced vandetanib induced myocardial injury by regulating redox balance and NLRP3 inflammasome pathway.
Beneficial effects of Akkermansia muciniphila on benign prostatic hyperplasia and metabolic syndrome.
Application of (68)Ga- and (177)Lu-Labeled FAP Inhibitor in Evaluation and Treatment of Cardiac Fibrosis After Myocardial Infarction.
H3K18 lactylation-mediated SIX1 upregulation contributes to silica-induced epithelial-mesenchymal transition in airway epithelial cells.
MTMR7 attenuates the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary hypertension by suppressing ERK/STAT3 signaling.
Metformin Attenuates Partial Epithelial-Mesenchymal Transition in Salivary Gland Inflammation via PI3K/Akt/GSK3β/Snail Signaling Axis.
Neddylation of RhoA impairs its protein degradation and promotes renal interstitial fibrosis progression in diabetic nephropathy.
A thermosensitive hydrogel with synergistic stromal targeting and antitumor immunity modulation for pancreatic cancer immunotherapy.
Shuangshi Tonglin Capsule Improves Prostate Fibrosis through Nrf2/TGF-β1 Signaling Pathways.
miR-145-enriched BMSCs-derived exosomes ameliorate neurogenic erectile dysfunction in aged rats via TGFBR2 inhibition.
Antitumour and anti-angiogenesis efficacy of a multifunctional self-oxygenated active-targeting drug delivery system by encapsulating biological and chemotherapeutic drugs.
A Novel Nude Mice Model for Studying the Pathogenesis of Keloid.
Ultrasound-responsive taurine lipid nanoparticles attenuate oxidative stress and promote macrophage polarization for diabetic wound healing.
Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways.
A telescopic microscope equipped with a quanta image sensor for live-cell bioluminescence imaging.
MBD2 promotes epithelial-to-mesenchymal transition (EMT) and ARDS-related pulmonary fibrosis by modulating FZD2.
PPAR-gamma agonist pioglitazone improves endometrial receptivity, reverses endometrial barrier disruption and promotes ovarian function in thin endometrium rats via modulation PPAR-γ/Wnt5/β-catenin pathway.
Phenotypic screening uncovered anti-myocardial fibrosis candidates using a novel 3D myocardial tissue under hypoxia.
Diabetic wound healing breakthrough: theaflavin-3, 3'-digallate nanoparticles@hydrogel activates the TGF-β1/SMAD3 pathway.
Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury.
GRK2-facilitated TLR4 signaling promotes cardiac fibrosis in rheumatic mice.
TIMP1 regulation of cardiac fibroblast proliferation via the TGF-β/Smad pathway in an in vitro model of atrial fibrillation.
Rebastinib attenuates acute lung injury by promoting NLRP3 ubiquitination and blocking NLRP3/GSDMD signaling pathway in macrophages and protecting alveolar epithelial cells.
Therapeutic potential of targeting the NEDD4L-eEF1A1 axis in cancer therapy.
Macrophage extracellular traps as key mediators of scleral remodeling in myopia induced by hypoxia and activated platelets.
Daidzein alleviates CCl(4)- and BDL-induced liver fibrosis via suppressing the integrin alphaVbeta1/YAP signaling.
Carbon monoxide gas molecules: Therapeutic mechanisms in radiation-induced lung injury.
Activation of mechanosensitive ion channel Piezo1 linking metabolic reprogramming and pro-inflammatory responses in hepatocellular carcinoma.
Nobiletin from Citrus reticulata Blanco alleviates pulmonary fibrosis through inhibiting the PI3K/AKT pathway and epithelial-mesenchymal transition.
Chemical compounds from Allii Tuberosi Semen exhibiting anti-fibrotic effects on hepatic stellate cells.
FOXO1 contributes to cigarette smoke condensate-induced cellular senescence and fibrosis in lung fibroblasts through activating the TGF-β1/Smad2/3 signaling pathway.
RGD peptide hydrogel downregulates mechanosignal YAP to inhibit postoperative scarring.
Discovery of novel selective HDAC6 inhibitors via a scaffold hopping approach for the treatment of idiopathic pulmonary fibrosis (IPF) in vitro and in vivo.
Integrated transcriptomics and metabolomics unravel the key metabolic pathways involved in the therapeutic mechanism of Salvianic acid A against hepatic fibrosis.
Sinomenine Ameliorates Liver Fibrosis by Blocking TGF-β/SMAD and c-JUN Signaling.
Methacrylated sericin/methacrylated hyaluronic acid composite microneedles with exosomes for diabetic wound healing.
UCP1 prevents the formation of thoracic aortic aneurysms and dissection by inhibiting the TLR4/NLRP3/IL-1β signaling pathway and VSMC phenotype switching in mice.
A-485 alleviates fibrosis and apoptosis in kidney by disrupting tandem activation of acetylation and phosphorylation on STAT3.
The KSR1/MEK/ERK signaling pathway promotes the progression of intrauterine adhesions.
Fucoxanthin Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Mice via Nrf2/HO-1/GPX4-Mediated Ferroptosis Pathway.
Inhibition of RACK1-Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome.
Tβ4-Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing.
Calpain-2-Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection.
Ubiquitin Specific Protease 9X Regulates the Activation of ARK5 and Promotes Progression of Fibrotic Remodeling.
Dermal papilla cells-conditioned medium attenuates oxidative stress-induced senescence via ferroptosis inhibition.
Xiaoyu Xiezhuo Decoction Ameliorates Tubulointerstitial Fibrosis by Modulating Gut-Kidney Axis and Aldosterone Signaling Pathway in UUO Rats.
Disintegrin Rhodostomin Mutant Ameliorates the Severity of Experimental Proliferative Vitreoretinopathy by Suppressing Both Integrin αvβ3 and α5β1.
Hypoxia Induces HIF-1α Activation in Tendon Stem Cells to Enhance Extracellular Vesicle-Mediated Tendon Repair.
Pantothenic acid ameliorates hepatic fibrosis by targeting IGFBP6 to regulate the TGF-β/SMADs pathway.
Salvianolic Acid B Attenuates Liver Fibrosis via Suppression of Glycolysis-Dependent m1 Macrophage Polarization.
FBP1 as a key regulator of focal adhesion kinase-mediated hepatic stellate cell activation: Multi-omics and experimental validation.
Wikstdaphnoids A-I, Daphnane Diterpenoid Orthoesters from Wikstroemia chamaedaphne with Anti-Liver Fibrosis Activity.
Identifying fibroblast-derived sFRP2 as a therapeutic target and engineering siRNA therapy for uterine scarring.
Gluconic acid alleviates hypertrophic scar formation through binding PLOD1, reducing p-AKT signaling and activating autophagy.
Mechanistic exploration of Dahuang Zhechong Pill against hepatic fibrosis via integrated serum pharmacochemistry, UHPLC-ESI-QTOF-MS/MS, network pharmacology, and molecular docking with cellular and zebrafish validation.
Bioactive fraction of processed Curcumae Rhizoma-Sparganii Rhizoma anti-liver fibrosis by regulate taurine metabolism through PI3K/AKT pathway.
ATG7-deficient fibroblast promotes breast cancer progression via exosome-mediated downregulation of SCARB1.
Ameliorating Myocardial Infarction by Concurrent Pyroptosis Suppression and On-Demand Oxygen Production via Functionalized Nanocarrier.
Astragalin promotes HSCs ferroptosis through NCOA4 mediated ferritinophagy to alleviate liver fibrosis in zebrafish and mice.
High-Fat Diet-Induced Diabetic Cardiomyopathy in Female Zebrafish: Cardiac Pathology and Functional Decline Mediated by Type 2 Diabetes.
Integrated analyses to explore the mechanism of Gancao Renshen Zhixue Decoction in treating liver cirrhosis.
Single-cell RNA sequencing in human atherosclerotic plaques reveals a novel smooth muscle cell subtype that possesses multi differentiation potential and shapes the microenvironment.
CXCL12-targeting siRNA nanoparticles alleviate immunosuppression and inhibit tumor progression in esophageal squamous cell carcinoma.
Exploring PU.1 as a Therapeutic Target to Mitigate Oxidative Stress and Inflammation in Peritoneal Dialysis-Induced Peritoneal Fibrosis.
Mitochondrial Calcium Uniporter-Mediated Regulation of the SIRT3/GSK3β/β-Catenin Signaling Pathway in Vascular Remodeling.
Pan-cancer human brain metastases atlas at single-cell resolution.
Characterizing the Impact of Fabrication Methods on Mechanically Tunable Gelatin Hydrogels for Cardiac Fibrosis Studies.
Alleviation of fibrosis and oxidative stress in pressure overload-induced cardiac remodeling and heart failure via SIRT3 activation by colchicine.
Kaempferol Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice by Regulating Intestinal Short-Chain Fatty Acids.
Nonylphenol exposure induces myocardial fibrosis via the RhoA/ROCK1/MLC-signaling pathway.
Autoimmune regulator deficiency causes sterile epididymitis and impacts male fertility through disruption of inorganic physiology.
Sintilimab and anlotinib with gemcitabine plus cisplatin in advanced biliary tract cancer: SAGC a randomized phase 2 trial.
Comparison of the effects of Liraglutide, Tirzepatide, and Retatrutide on diabetic kidney disease in db/db mice.
Network pharmacology, molecular docking, and experimental verification to reveal the mechanism of colquhounia root tablet in the treatment of diabetic nephropathy.
Slit2 Promotes H(2)O(2)-Induced Lens Epithelial Cells Oxidative Damage and Age-Related Cataract.
Shionone Inhibits Glomerular Fibirosis by Suppressing NLRP3 Related Inflammasome though SESN2-NRF2/ HO-1 Pathway.
USP11 promotes renal tubular cell pyroptosis and fibrosis in UUO mice via inhibiting KLF4 ubiquitin degradation.
NOTCH3 Mutation Causes Glymphatic Impairment and Promotes Brain Senescence in CADASIL.
Identification the Cellular Senescence Associated lncRNA LINC01579 in Gastric Cancer.
Renal Tubular Epithelial Cell-Derived hsa_circ_0008925 From Urine Is Related to Chronic Renal Fibrosis.
A polysaccharide from Glycyrrhiza uralensis attenuates myocardial fibrosis via modulating the MAPK/PI3K/AKT signaling pathway.
Enhancing epithelial regeneration with gelatin methacryloyl hydrogel loaded with extracellular vesicles derived from adipose mesenchymal stem cells for decellularized tracheal patching.
A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2.
Increased NPM1 inhibit ferroptosis and aggravate renal fibrosis via Nrf2 pathway in chronic kidney disease.
Research on the anti-hepatic fibrosis effects and active components of the medicinal plant Tithonia diversifolia.
Design, synthesis, and biological evaluation of novel 3-naphthylthiophene derivatives as potent SIRT2 inhibitors for the treatment of myocardial fibrosis.
Multi-omics analysis reveals the protective effects of Chinese yam polysaccharide against cisplatin-induced renal interstitial fibrosis.
Circ-ECH1 May Compete With miR-708-5p to Regulate Ntrk2 in Bronchopulmonary Dysplasia.
Macrophages overexpressing interleukin-10 target and prevent atherosclerosis: Regression of plaque formation and reduction in necrotic core.
Knockdown of AMFR Alleviates Atrial Fibrosis in Atrial Fibrillation by Stabilizing SOD1 Protein Expression.
Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection: A natural ingredient strategy.
Estrogen Receptor β Activation Mitigates Colitis-associated Intestinal Fibrosis via Inhibition of TGF-β/Smad and TLR4/MyD88/NF-κB Signaling Pathways.
Cromolyn sodium reduces LPS-induced pulmonary fibrosis by inhibiting the EMT process enhanced by MC-derived IL-13.
Senolytic procyanidin C1 alleviates renal fibrosis by promoting apoptosis of senescent renal tubular epithelial cells.
Pharmacological effects and mechanisms of danlong oral liquid in asthma airway remodeling: Insights from serum medicinal chemistry, network pharmacology, and experimental validation.
Baricitinib represses the myocardial fibrosis via blocking JAK/STAT and TGF-β1 pathways in vivo and in vitro.
Lemon-derived nanoparticle-functionalized hydrogels regulate macrophage reprogramming to promote diabetic wound healing.
Qianyang Yuyin granules alleviate hypertension-induced vascular remodeling by inhibiting the phenotypic switch of vascular smooth muscle cells.
Comparison of chemical composition between imitation wild and transplanted Astragali Radix and their therapeutic effects on heart failure.
Atractylenolide-III restrains cardiac fibrosis after myocardial infarction via suppression of the RhoA/ROCK1 and ERK1/2 pathway.
Ginsenoside Rd protects against acute liver injury by regulating the autophagy NLRP3 inflammasome pathway.
UHRF1 promotes epithelial-mesenchymal transition mediating renal fibrosis by activating the TGF-β/SMAD signaling pathway.
Immunopathological characteristics and therapeutic effects of UC-MSCs in a pigeon breeder's lung mouse model.
Polystyrene microplastics induce liver fibrosis and lipid deposition in mice through three hub genes revealed by the RNA-seq.
Engineering spatially-confined conduits to tune nerve self-organization and allodynic responses via YAP-mediated mechanotransduction.
Prolonged tamoxifen treatment induces iron deposition and ferroptosis in the liver.
Protective effects of Notoginsenoside R2 on reducing lipid accumulation and mitochondrial dysfunction in diabetic nephropathy through regulation of c-Src.
Autoimmune regulator deficiency causes sterile epididymitis and impacts male fertility through disruption of inorganic physiology.
Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice.
Wenshen Xiaozheng Tang alleviates fibrosis in endometriosis by regulating differentiation and paracrine signaling of endometrium-derived mesenchymal stem cells.
Cancer-associated fibroblasts induce almonertinib resistance in non-small cell lung cancer.
Exosomes derived from TREM-2 knocked-out macrophages alleviated renal fibrosis via HSPa1b/AKT pathway.
Anisodamine ameliorates crystalline silica-exposed pulmonary inflammation and fibrosis via the α7nAChR/JAK2/STAT3 signaling pathway.
Bleomycin pollution and lung health: The therapeutic potential of peimine in bleomycin-induced pulmonary fibrosis by inhibiting glycolysis.
Integrating Network Pharmacology and In Vitro Experimental Verification Revealing Bushenhuoxue Recipe Against Intrauterine Adhesions via PI3K-AKT Signaling Pathway.
Nicotinamide N-methyltransferase negatively regulates metastasis-promoting property of cancer-associated fibroblasts in lung adenocarcinoma.
The effect of tocilizumab treatment for skin fibrosis by inhibiting CD38(+) macrophages in systemic sclerosis.
Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis.
Pharmacokinetics Integrated With Network Pharmacology to Investigate the Potential Mechanism of Lu-Jiao Fang Inhibited Endothelial-to-Mesenchymal Transition in Pressure Overload-Induced Cardiac Fibrosis.
Novel full-thickness biomimetic corneal model for studying pathogenesis and treatment of diabetic keratopathy.
Negative air ions alleviate nicotine-induced renal damage of spontaneously hypertensive rats via inhibiting oxidative stress and TGF-β/Smad pathway.
Integrated UHPLC-Q-exactive orbitrap HRMS and serum pharmacochemistry for the investigation of anti-hepatic fibrosis effect of Baoganning Decoction.
Curcumol ameliorates alcohol and high-fat diet-induced fatty liver disease via modulation of the Ceruloplasmin/iron overload/mtDNA signaling pathway.
CB-MNCs@ CS/HEC/GP promote wound healing in aged murine pressure ulcer model.
Metal-organic framework-based nanoplatforms for synergistic anti-atherosclerosis therapy by regulating the PI3K/AKT/MSR1 pathway in macrophages.
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis.
MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy.
Cloned airway basal progenitor cells to repair fibrotic lung through re-epithelialization.
Dedifferentiated fat cells-derived exosomes (DFATs-Exos) loaded in GelMA accelerated diabetic wound healing through Wnt/β-catenin pathway.
Danggui niantong decoction attenuates synovial fibrosis through regulating PI3k/AKT signaling pathway.
MTHFD2 stabilizes LOX expression through RNA methylation modification to promote sepsis-induced acute kidney injury progression.
Visualizing spatiotemporal pattern of vascularization by SWIR fluorescence imaging in a mouse model of perforator flap transplantation.
Nucleolin in the cell membrane promotes Ang II-mediated VSMC phenotypic switching by regulating the AT1R internalization function : Nucleolin promotes Ang II-mediated VSMC phenotypic switching.
Ether bond-modified lipid nanoparticles for enhancing the treatment effect of hepatic fibrosis.
ITIH5-mediated fibroblast/macrophage crosstalk exacerbates cardiac remodelling after myocardial infarction.
Drop-shaped microgrooves guide unidirectional cell migration for enhanced endothelialization.
The natural product-derived JM-9 alleviates high-fat diet-induced fatty liver in mice by targeting MD2.
Interferon regulatory factor 5 attenuates kidney fibrosis through transcriptional suppression of Tgfbr1.
The loss of Spinster homolog 2 drives endothelial mesenchymal transition via SMS2-mediated disruption of sphingomyelin metabolism.
Growth Differentiation Factor 15 Inhibits Cardiac Fibrosis, Oxidative Stress, Inflammation, and Apoptosis in a Rat Model of Heart Failure with Preserved Ejection Fraction.
IFN-γ-mediated inhibition of JAK/STAT signaling via nano-scutellarin treatment is an efficient strategy for ameliorating liver fibrosis.
miR-629-3p inhibits fine particulate matter exposure-induced lung function decline: Results from the two-stage population study and in vitro study.
Modulation of almonertinib resistance in non-small cell lung cancer by cancer-associated fibroblasts through HK2-mediated glycolysis and SKP2 signaling.
SCGB1D4 downregulation links to fibrosis in intrauterine adhesion patients and rat models†.
Aqueous extract of Cornus officinalis alleviate NAFLD via protecting hepatocytes proliferation through regulation of the tricarboxylic acid cycle.
Intelligent sequential degradation hydrogels by releasing bimetal-phenolic for enhanced diabetic wound healing.
Runx2-NLRP3 axis orchestrates matrix stiffness-evoked vascular smooth muscle cell inflammation.
Plasma-activated solutions prevent peritoneal adhesion formation by regulating eNOS expression in mesothelial cells.
SPP1-mediated crosstalk between macrophage and fibroblasts promotes benign airway stenosis.
Uncovering the mechanistic basis of Rheum palmatum L. (rhubarb) in the treatment of chronic kidney disease: an integrative approach using network pharmacology, molecular docking, and experimental validation.
Cancer-associated fibroblast-derived extracellular vesicles regulate lipophagy through PLIN2 to modulate dormancy in salivary gland adenoid cystic carcinoma cells.
Qing-Re-Xiao-Zheng-yi-qi formula protects renal function by stabilizing lysosomal membranes and inhibiting NLRP3-inflammasome-mediated pyroptosis in diabetic kidney disease.
PAI-1 deficiency inhibits endometrial fibrosis via modulation of the FAK/Src/ERK and AKT signalling pathways.
Concentrated Micronized Fat Ameliorates Skin Fibrosis in Bleomycin-Induced Murine Model and Enhances Fat Graft Survival.
LARS1 Promotes Tubular Epithelial Cells Epithelial Mesenchymal Transition in Chronic Kidney Disease by Inhibiting Lipophagy.
Irisin targets the HK1-glycolysis-NLRP3 pyroptosis axis to prevent chronic kidney disease-associated vascular calcification.
Aucubin ameliorates diabetic kidney disease by restoring hGENCs autophagy through promoting phosphorylation of ATG4B protein.
Gut microbiota-derived butyrate prevents aortic dissection via GPR41.
Mulberry-derived carbon dots attenuate kidney fibrosis through direct inhibition of PI3K.
Deoxycholic Acid and Lipoteichoic Acid cooperatively drive macrophage M2/M1 polarization via TGR5/STAT3 and TLR2/NF-κB to fuel HCC progression in obesity.
Hypericin-mediated photodynamic therapy promotes apoptosis and inhibits fibrosis by inducing HMOX1-mediated ferroptosis in hypertrophic scar fibroblasts.
Myofibroblast specific knockdown of NSUN2 suppresses cardiac fibrosis post-myocardial infarction.
Injectable, antifouling granular zwitterionic hydrogels for preventing postoperative intrauterine adhesion and restoring fertility.
Unveiling the role of Jagged2 in hypoxic pulmonary arterial hypertension: A NOX2-mediated pathway.
Targeting the ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3Gal1) as a potential therapeutic strategy to overcome anti-VEGF resistance in endometrial cancer.
Viscoelastic Hydrogel with Mechanomodulatory Tension Shielding and Time-Dependent Immunomodulatory Effects for Scarless Healing.
Hispolon reduces mitochondrial dysfunction and improves fibrosis of diabetes nephropathy by activating AMPK signal and inhibiting mPTP opening.
Formononetin, a Key Component of Danggui Buxue Decoction, Inhibits Metastasis of Triple-Negative Breast Cancer by Modulating SNAI2-Driven EMT.
Defective vascular smooth muscle cell tafazzin impairs mitochondrial function and promotes atherosclerosis in preclinical models.
Lathyrol Exerts Anti-Pulmonary Fibrosis Effects by Activating PPARγ to Inhibit the TGF-β/Smad Pathway.
HMGB1-enhanced autophagic degradation of E-cadherin facilitates mesothelial trans-differentiation and postoperative peritoneal adhesion.
He-He-Shu-Yang formula alleviates liver fibrosis by inhibiting hepatic stellate cell activation in vivo and in vitro.
SREBP1-mediated lipogenesis promotes dedifferentiation and senescence of vascular smooth muscle cells through epigenetic remodeling.
Single-cell RNA sequencing identifies ZBP1-dependent mechanisms in OSCC progression.
Saffron and Calculus bovis combination exerts anti-hepatic fibrotic effect in liver fibrosis rats via the mitogen-activated protein kinases pathway.
CD146(+) CAFs mediate immunosuppression in gastric cancer via COL4A1: potential therapeutic targets.
Vitisin A inhibits liver fibrosis by promoting Nrf2/HO-1 pathway and inhibiting Cuproptosis.
Lupiwighteone Ameliorates Diabetic Nephropathy-Induced Renal Fibrosis via SIRT1/NF-κB Signaling Pathway-Mediated Inflammatory Response.
Multi-omics factor analysis identifies the Tensin 1-Fermitin family homologue 2-Fibronectin 1-Integrin signaling axis as a prognostic determinant in colorectal cancer.
In vitro and in vivo hemocompatibility study of fish swim bladder-derived biomaterials for the application of chronic venous disease.
Alkaline Phosphatase-Triggered Spatiotemporal Repair of Corneal Injury with TB500 Peptide Hydrogel.
HPDA-based tubule-targeting nanoplatform alleviates oxidative stress and ferroptosis for the reversal of renal interstitial fibrosis.
Human umbilical cord-derived mesenchymal stem cells ameliorate non-alcoholic fatty liver disease via activating TFEB-mediated autophagy in male mice.
Heterogeneity of common carotid artery and abdominal aorta: an angle of sphingolipid metabolism in vascular smooth muscle cells.
Renal insulin-like growth factor binding-protein 7 is a critical promoter of progressive diabetic kidney disease.
Activation/inactivation of Tregs mediated by Kv1.3 potassium channels synergistically with exosome secretion to regulate myocardial fibrosis.
Comparative study of bladder augmentation using different biomimetic scaffolds: electrospun nanofiber vs. extracellular matrix scaffold with adipose-derived stem cells.
RalGAP complexes control secretion and primary cilia in pancreatic disease.
Pathology-inspired collagen-binding thermosensitive micelle drops enable prolonged and efficient treatment of fungal keratitis.
Aerobic exercise activates let-7e-5p through TP73-AS1 to inhibit the HMGB1/RAGE axis and alleviate asthma airway inflammation and remodeling.
Adhesive hydrogel based on Konjac Glucomannan (KGM) loaded with siACTC1-exosomes for enhanced post-surgical keloid treatment.
Influence of Huaiqihuang granule on peritoneal fibrosis induced by peritoneal dialysis: A study based on rat model.
The role of FAK in renal collecting duct in the progression from acute kidney injury to chronic kidney disease.
p66shc exacerbates the progression of obstructive nephropathy through apoptosis, mitochondrial damage, and EMT.
m6A-mediated regulation of ECA39 promotes renal fibrosis in chronic kidney disease by enhancing glycolysis and epithelial-mesenchymal transition.
Inhibition of VSMC Ferroptosis Mitigates Pathological Vascular Remodeling: A Novel Therapeutic Strategy for Abdominal Aortic Aneurysm.
Revealing a new target: Celastrol alleviates pulmonary fibrosis by inhibiting PCAF.
Engineered MSC Aggregates with E/N-Cadherin and IL-6 Preconditioning for the Treatment of Systemic Sclerosis.
Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Combined with PEG Hydrogel Alleviate Maternal Simulated Birth Injury in a Rat Model.
F-box only protein 10 protects against kidney tubulointerstitial fibrosis by inhibiting ACSL4-mediated lipid peroxidation and ferroptosis.
Oxidized-LDL aggravates renal injury via tubular cuproptosis.
Vascular Smooth Muscle-Secreted Exosomal X26nt Impedes Atherosclerosis Progression via the c-FOS/XBP1/SOD1 Axis.
Paracrine Orchestration of Tumor Microenvironment Remodeling Induced by GLO1 Potentiates Lymph Node Metastasis in Breast Cancer.
PGC1α regulates the mitochondrial metabolism response to cyclic stretch, which inhibits neointimal hyperplasia.
SETD2 drives METTL14-mediated m(6)A to suppress Piezo1 Attenuation and activate TGM2 to promote pulmonary hypertension.
Neurotensin receptor1 signaling promotes progression of epithelial-mesenchymal transition in mice with chronic rhinosinusitis through Wnt3a/β-catenin pathway.
Renal tubular epithelial IGFBP7 interacts with PKM2 to drive renal lipid accumulation and fibrosis.
SRPK1 is a significant factor in driving the progression of diabetic kidney fibrosis.
Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation.
A Bifunctional Anti-PD-1/TGF-β Fusion Antibody Restores Antitumour Immunity and Remodels the Tumour Microenvironment.
Therapeutic and prophylactic effects of Qipian on COPD in mice: the role of lung and gut microbiota.
Kurarinone protects against renal injury and fibrosis after unilateral ureteral obstruction through enhancement of the Nrf-2 signaling pathway.
Activated Schwann cells promote tumor growth in colon cancer.
Silybin Mitigates Post-Myocardial Infarction Heart Failure in Mice via Modulation of HIF-1α-Driven Glycolysis and Energy Metabolism.
S100a8 inhibitor Paquinimod attenuates coal dust-induced pulmonary fibrosis via blocking neutrophils-S100a8-Tlr4-macrophages signaling axis.
Induction and characterization of oral submucous fibrosis model with different pathological stages in rats and mice.
Ultrasound-triggered targeted delivery of engineered ADSCs-derived exosomes with high SDF-1α levels to promote cardiac repair following myocardial infarction.
Hypoxia-induced exosomal circNRIP1 activates cancer-associated fibroblasts to promote esophageal squamous cell carcinoma migration and invasion.
Eupatorium lindleyanum DC Ameliorates Carbon Tetrachloride-Induced Hepatic Inflammation and Fibrotic Response in Mice.
Phosphoglycerate kinase 1 contributes to diabetic kidney disease through enzyme-dependent and independent manners.
The protective role of ureteral stents in reducing fibrosis and preventing stricture in ureteral injuries of different severities.
Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury.
Cancer cell SPOCD1 promotes colorectal cancer liver metastasis by activating the CXCL12/CXCR4 signaling pathway in cancer-associated fibroblasts.
Sorafenib inhibits ovarian inflammation and fibrosis in polycystic ovary syndrome by targeting the PDGFA/PDGFRα/NF-κB pathway in granulosa cells†.
NAT10 Mediates Cardiac Fibrosis Induced by Myocardial Infarction Through ac4C Modification of TGFBR1 mRNA.
Targeted Delivery of CD34 Aptamer-Coupled Tocilizumab Microspheres for Effective Treatment of Thyroid-Associated Ophthalmopathy.
Integrated Proteomics Reveals Spliceosome Dysregulation and Highlights DHX9 as a TGF-β Signaling-Driven Fibrosis Hub in Endometriosis.
Anti-Radiofibrosis Effect of Dicliptera chinensis Polysaccharide on Rat Dermal Fibroblasts Via The TGF-β1/Smads/CTGF Signaling Pathway.
Spatially resolved transcriptomic analysis of the adult human prostate.
Agathis dammara Extract and its Monomer Araucarone Attenuate Abdominal Aortic Aneurysm in Mice.
Engineered MSCs Break Endothelial-Myofibroblast Crosstalk in Pulmonary Fibrosis: Reconstructing the Vascular Niche.
CIP2A promotes bronchiolitis obliterans by activating the NF‑κB pathway.
Role of the integrin‑β1/TGF‑β1 signaling pathway in the pathogenesis of pelvic organ prolapse: A study on vaginal wall tissue alterations and molecular dysfunction.
Uniform and controllable surface nano-structure on polyetheretherketone implants can regulate mechanical property to enhance soft tissue integration through Piezo1/TGF-β1 signaling axis.
Exosome-loaded tannic acid-thioctic acid hydrogel enhances wound healing in coagulation disorders.
circSIRT2/miR-542-3p/VASH1 axis regulates endothelial-to-mesenchymal transition (EndMT) in subretinal fibrosis in age-related macular degeneration models.
Targeting PDK1: A novel approach to combat hypoxia-induced epithelial-mesenchymal transition in chronic rhinosinusitis with nasal polyps.
CircHOMER1 promotes silica-induced pulmonary fibrosis by binding to HuR and stabilizing NOX4 mRNA.
Deficiency of HSF4 Increases the Secretion of Small Extracellular Vesicles via Upregulation of Chaperone-Mediated Autophagy.
Construction of a Biomimetic Tubular Scaffold Inspired by Sea Sponge Structure: Sponge-Like Framework and Cell Guidance.
Electret-Inspired Charge-Injected Hydrogel for Scar-Free Healing of Bacterially Infected Burns Through Bioelectrical Stimulation and Immune Modulation.
Metformin Alleviates Fibrosis of Trabecular Meshwork Cells Induced by TGFβ2 Through the Activation of Autophagy.
Microenvironment-adaptive nanomedicine MXene promotes flap survival by inhibiting ROS cascade and endothelial pyroptosis.
Suppression of Liver Fibrogenesis with Photothermal Sorafenib Nanovesicles via Selectively Inhibiting Glycolysis and Amplification of Active HSCs.
Intranasal delivery of R8-modified circNFXL1 liposomes ameliorates Su5416-induced pulmonary arterial hypertension in C57BL/6 mice.
LncRNA-5829: a novel inhibitor of cardiac fibrosis.
OTUD1 inhibits endometriosis fibrosis by deubiquitinating MADH7.
Cathepsin D inhibits AGEs-induced phenotypic transformation in vascular smooth muscle cells.
KIF2C promotes oral squamous cell carcinoma progression via PLK1 upregulation: implications for biomarker development and therapeutic targeting.
PYK2 promotes cell proliferation and epithelial-mesenchymal transition in endometriosis by phosphorylating Snail1.
Development of a Long-Acting Interleukin-11 Antagonist for the Treatment of Renal Fibrosis.
USP22/BRD4 mediated hedgehog pathway activation contributes to airway remodeling in asthma.
Mechanism of Astragalus Polysaccharide in Alleviating Bovine Mammary Fibrosis Through ROS/NLRP3 Inhibition and EMT Regulation.
Estrogen Inhibits the Phenotypic Switching of Vascular Smooth Muscle Cells through ER-α/CREB in Aortic Dissection.
Autophagy inhibition enhances antifibrotic potential of placental mesenchymal stem cells of fetal origin via regulating TGF-β1 mediated protein degradation of HGF.
Deficiency of IL-7R attenuates abdominal aortic aneurysms in mice by inhibiting macrophage polarization towards M1 phenotype through the NF-κB pathway.
Epithelial FETUB-mediated the inhibition of NEP activity aggravates asthma.
miR-29 inhibits endothelial-to-mesenchymal transition in pulmonary hypertension of the newborn by regulating LRP6.
Galectin-1 regulates scar hyperplasia by modulating NASP variable splicing to generate ROS.
NLRP3 inflammasome-mediated premature immunosenescence drives diabetic vascular aging dependent on the induction of perivascular adipose tissue dysfunction.
Molecular network strategies combined with MCnebula2 identify potential active compounds from steamed Polygonatum cyrtonema Hua.
The sonic hedgehog signaling inhibitor cyclopamine improves pulmonary arterial hypertension via regulating the bone morphogenetic protein receptor 2 pathway.
The CD163 + tissue-infiltrating macrophages regulate ferroptosis in thyroid-associated ophthalmopathy orbital fibroblasts via the TGF-β/Smad2/3 signaling pathway.
Lack of ALCAT1 enhances the protective effects of aerobic exercise on kidney in HFpEF mice.
Triclosan exposure induces liver fibrosis in mice: The heterogeneous nuclear ribonucleoprotein A1/pyruvate kinase M2 axis drives hepatic stellate cell activation.
Effect of Engineered Cyanobacterial Capsules on a Neurogenic Bladder after Spinal Cord Injury.
Identification and validation of CDC20 and ITCH as ubiquitination related biomarker in idiopathic pulmonary fibrosis.
An Integrated Dual-Layer Heterogeneous Polycaprolactone Scaffold Promotes Oral Mucosal Wound Healing through Inhibiting Bacterial Adhesion and Mediating HGF-1 Behavior.
Fabrication of 3D Biomimetic Smooth Muscle Using Magnetic Induction and Bioprinting for Tissue Regeneration.
PR/SET domain 1 targeting glutathione peroxidase 4 regulates chronic hepatitis B liver fibrosis through ferroptosis.
Comparative Analysis of the Therapeutic Effects of MSCs From Umbilical Cord, Bone Marrow, and Adipose Tissue and Investigating the Impact of Oxidized RNA on Radiation-Induced Lung Injury.
Combination of Pirfenidone and Andrographolide Ameliorates Hepatic Stellate Cell Activation and Liver Fibrosis by Mediating TGF-β/Smad Signaling Pathway.
Hepatobiliary organoids differentiated from hiPSCs relieve cholestasis-induced liver fibrosis in nonhuman primates.
Irisin ameliorates UUO-induced renal interstitial fibrosis through TGF-β1/periostin/MMP-2 signaling pathway.
Astragaloside IV alleviates renal fibrosis by inhibiting renal tubular epithelial cell pyroptosis induced by urotensin II through regulating the cAMP/PKA signaling pathway.
TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway.
Combined Placental Mesenchymal Stem Cells with Guided Nanoparticles Effective Against Diabetic Nephropathy in Mouse Model.
Antioxidant Carbon Dots and Ursolic Acid Co-Encapsulated Liposomes Composite Hydrogel for Alleviating Adhesion Formation and Enhancing Tendon Healing in Tendon Injury.
Liposomes Loaded with 5-Fluorouracil Can Improve the Efficacy in Pathological Scars.
Nanofabrications of Erythrocyte Membrane-Coated Telmisartan Delivery System Effective for Radiosensitivity of Tumor Cells in Mice Model.
Reduced Proliferative Capacity and Defense against Staphylococcus aureus in Human Nasal Mucosal Epithelium Lacking ZNF365.
RASSF4 Attenuates Metabolic Dysfunction-Associated Steatotic Liver Disease Progression via Hippo Signaling and Suppresses Hepatocarcinogenesis.
The Mechanism of Catalpol to Improve Oxidative Damage of Dermal Fibroblasts Based on Nrf2/HO-1 Signaling Pathway.
miR-34b-5p suppresses the epithelial-mesenchymal transition and metastasis in endometrial cancer AN3CA cells by targeting ZEB1.
Claudin-2 Mediates the Proximal Tubular Epithelial Cell-Fibroblast Crosstalk via Paracrine CTGF.
Seed and Soil: Consensus Molecular Subgroups (CMS) and Tumor Microenvironment Features Between Primary Lesions and Metastases of Different Organ Sites in Colorectal Cancer.
Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activating the Nrf2/HO-1 pathway.
Qizhu Rougan Granules suppress liver fibrosis by inhibiting the expression of the P2Y14 receptor on hepatic stellate cells.
Yishen paidu pills attenuates 5/6 nephrectomy induced kidney disease via inhibiting the PI3K/AKT/mTOR signaling pathway.
Hypoxia reconstructed colorectal tumor microenvironment weakening anti-tumor immunity: construction of a new prognosis predicting model through transcriptome analysis.
Identification and verification of the optimal feature genes of ferroptosis in thyroid-associated orbitopathy.
Thonningianin A ameliorated renal interstitial fibrosis in diabetic nephropathy mice by modulating gut microbiota dysbiosis and repressing inflammation.
Inhibition of ACOX1 enhances the therapeutic efficacy of obeticholic acid in treating non-alcoholic fatty liver disease and mitigates its lipotoxicity.
LINC00982-encoded protein PRDM16-DT regulates CHEK2 splicing to suppress colorectal cancer metastasis and chemoresistance.
HIF2A mediates lineage transition to aggressive phenotype of cancer-associated fibroblasts in lung cancer brain metastasis.
Twist-related protein 1 promotes transforming growth factor β receptor 1 in keloid fibroblasts via regulating the stability of myocyte enhancer factor 2A.
Hypoxia macrophage-derived exosomal miR-26b-5p targeting PTEN promotes the development of keloids.
Hsa_circ_0009096/miR-370-3p modulates hepatic stellate cell proliferation and fibrosis during biliary atresia pathogenesis.
Ultra-small curcumin-ruthenium coordination polymer nanodots prevent renal ischemia-reperfusion injury and the progression to chronic kidney disease.
The clinical impact of macrophage polarity after Kasai portoenterostomy in biliary atresia.
Assessment of hypoxia status in a rat chronic liver disease model using IVIM and T1 mapping.
GSDMB involvement in the pathogenesis of abdominal aortic aneurysm through regulation of macrophage non-canonical pyroptosis.
Enhancing Fat Transplantation Efficiency in a Mouse Model through Pretreatment of Adipose-Derived Stem Cells with RIP3 Inhibitors.
Intervention of Asprosin Attenuates Oxidative Stress and Neointima Formation in Vascular Injury.
Morroniside improves AngII-induced cardiac fibroblast proliferation, migration, and extracellular matrix deposition by blocking p38/JNK signaling pathway through the downregulation of KLF5.
N6-methyladenosine triggers renal fibrosis via enhancing translation and stability of ZEB2 mRNA.
Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis.
Polystyrene microplastics facilitate renal fibrosis through accelerating tubular epithelial cell senescence.
Identification of miRNA signature in cancer-associated fibroblast to predict recurrent prostate cancer.
Mechanism of Zhenwu Decoction modulating TLR4/NF-κB/HIF-1α loop through miR-451 to delay renal fibrosis in type 2 CRS.
The role of α7nAchR and PD-L1 in neuroimmune regulation of keloid treatment.
Knockdown of programmed cell death factor 4 restores erectile function by attenuating apoptosis in rats with bilateral cavernous nerve crush injury.
Obstructive Sleep Apnea Syndrome Exacerbates NASH Progression via Selective Autophagy-Mediated Eepd1 Degradation.
Uremic Toxin Receptor AhR Facilitates Renal Senescence and Fibrosis via Suppressing Mitochondrial Biogenesis.
Acteoside delays the fibrosis process of diabetic nephropathy by anti-oxidation and regulating the autophagy-lysosome pathway.
3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration.
Identification of common biomarkers in diabetic kidney disease and cognitive dysfunction using machine learning algorithms.
GQ262 Attenuates Pathological Cardiac Remodeling by Downregulating the Akt/mTOR Signaling Pathway.
Cancer-associated fibroblast-derived exosome Leptin promotes malignant biological lineage in pancreatic ductal adenocarcinoma by regulating ABL2 via miR-224-3p.
Deficiency of geranylgeranyl biphosphate synthase in kidney tubules causes cystic kidney disease.
Exosome miRNA profile and mitigating effect of miR-23a-3p/Cul3 axis on apoptosis in the pathogenesis of SiO(2) dust-induced lung fibrosis.
Early inhibition of BRD4 facilitates iPSC reprogramming via accelerating rDNA dynamic expression.
Endosialin-positive CAFs promote hepatocellular carcinoma progression by suppressing CD8(+) T cell infiltration.
Insulin-transferrin-selenium promote formation of tissue-engineered vascular grafts in early stage of culture.
Toll-Like Receptor 9 Aggravates Pulmonary Fibrosis by Promoting NLRP3-Mediated Pyroptosis of Alveolar Epithelial Cells.
Target NF-κB p65 for preventing posttraumatic joint contracture in rats.
Novel glucomannan-like polysaccharide from Lycium barbarum L. ameliorates renal fibrosis via blocking macrophage-to-myofibroblasts transition.
Urine-Derived Stem Cells Reverse Bleomycin‑Induced Experimental Pulmonary Fibrosis by Inhibition of the TGF-β1-Smad2/3 Pathway.
Regulation of Fuzheng Huayu capsule on inhibiting the fibrosis-associated hepatocellular carcinogenesis.
Gentiana decoction inhibits liver fibrosis and the activation of hepatic stellate cells via upregulating the expression of Parkin.
Cinnamaldehyde activates AMPK/PGC-1α pathway via targeting GRK2 to ameliorate heart failure.
Neutrophil-Mediated Nanozyme Delivery System for Acute Kidney Injury Therapy.
LncRNA CCAT2 Knockdown Alleviates Pressure Overload or Ang II-Induced Cardiac Hypertrophy Via Disruption of the Wnt/β-Catenin Signaling.
Targeting Bacteria-Induced Ferroptosis of Bone Marrow Mesenchymal Stem Cells to Promote the Repair of Infected Bone Defects.
Polymeric immunoglobulin receptor promotes Th2 immune response in the liver by increasing cholangiocytes derived IL-33: a diagnostic and therapeutic biomarker of biliary atresia.
SMYD2 Promotes Calcium Oxalate-Induced Glycolysis in Renal Tubular Epithelial Cells via PTEN Methylation.
Vitamin D receptor attenuates carbon tetrachloride-induced liver fibrosis via downregulation of YAP.
Transcriptomic analysis reveals the critical role of chemokine signaling in the anti-atherosclerosis effect of Xuefu Zhuyu decoction.
The senolytic drug ABT-263 accelerates ovarian aging in older female mice.
LncRNA FEZF1-AS1 promotes pulmonary fibrosis via up-regulating EZH2 and targeting miR-200c-3p to regulate the ZEB1 pathway.
Quantitative proteomics reveals the mechanism of endoplasmic reticulum stress-mediated pulmonary fibrosis in mice.
The Toll-like receptor 4 antagonist TAK-242 in combination with sodium hyaluronate alleviates postoperative abdominal adhesion in a mouse model.
Autophagy activation ameliorates the fibrosis of trabecular meshwork cells induced by TGFβ2 through the promotion of fibrotic proteins degradation.
GLP-1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome/PFKFB3-driven glycolysis interaction and histone lactylation.
Nasal instillation of polystyrene nanoplastics induce lung injury via mitochondrial DNA release and activation of the cyclic GMP-AMP synthase-stimulator of interferon genes-signaling cascade.
Nr-CWS regulates METTL3-mediated m(6)A modification of CDS2 mRNA in vascular endothelial cells and has prognostic significance.
MiR-1307-5p enhances fibroblast transdifferentiation to exacerbate chronic obstructive pulmonary disease through regulating FBXL16/HIF1α axis.
NLRP3 inflammasome inhibition decreases Schistosomiasis japonica-induced granulomatous inflammation and fibrosis in BALB/c mice.
Novel Insight into the mechanism of di (2-ethylhexyl) phthalate (DEHP) impairing early follicle development.
NIR-II light based combinatorial management of hypertrophic scar by inducing autophagy in fibroblasts.
A proteomics-based study of the mechanism of oxymatrine to ameliorate hepatic fibrosis in mice.
Nesfatin-1 enhances vascular smooth muscle calcification through facilitating BMP-2 osteogenic signaling.
Deubiquitinase USP18 inhibits hepatic stellate cells activation and alleviates liver fibrosis via regulation of TAK1 activity.
Triclosan exposure causes abnormal bile acid metabolism through IL-1β-NF-κB-Fxr signaling pathway.
FOXO1-mTOR pathway in vascular pericyte regulates the formation of type H vessels to control bone metabolism.
TRIM65 deficiency alleviates renal fibrosis through NUDT21-mediated alternative polyadenylation.
The pH-sensitive chondroitin sulphate-based nanoparticles for co-delivery of doxorubicin and berberine enhance the treatment of breast cancer.
Three-dimensional bioprinted cell-adaptive hydrogel with anisotropic micropores for enhancing skin wound healing.
Early growth response 1 exacerbates thoracic aortic aneurysm and dissection of mice by inducing the phenotypic switching of vascular smooth muscle cell through the activation of Krüppel-like factor 5.
Hepatotoxic assessment in a microphysiological system: Simulation of the drug absorption and toxic process after an overdosed acetaminophen on intestinal-liver-on-chip.
Luteolin detoxifies DEHP and prevents liver injury by degrading Uroc1 protein in mice.
Fusion protein of FGF21 and elastin-like peptide improves wound healing in diabetic mice via inflammation modulation, collagen synthesis, and vascular network formation.
Targeting GPR39 in structure-based drug discovery reduces Ang II-induced hypertension.
Harnessing the regenerative effects of human amniotic stem cells (hAFSCs) on restoring erectile function in a bilateral cavernous nerve crush (BCNC) injury rat model.
Involvement of Melatonin, Oxidative Stress, and Inflammation in the Protective Mechanism of the Carotid Artery over the Torpor-Arousal Cycle of Ground Squirrels.
Impact of mesenchymal stem cell size and adhesion modulation on in vivo distribution: insights from quantitative PET imaging.
Excessive Supplement of l-Arginine Induces Myopia via Orchestrating the MEK-ERK-NO Signaling Pathway.
Target-Engineered Liposomes Decorated with Nanozymes Alleviate Liver Fibrosis by Remodeling the Liver Microenvironment.
ANGPTL4 promotes choroidal neovascularization and subretinal fibrosis through the endothelial‒mesenchymal transition.
DsbA-L activates TGF-β1/SMAD3 signaling and M2 macrophage polarization by stimulating AKT1 and NLRP3 to promote pulmonary fibrosis.
Gastrodin attenuates diabetic cardiomyopathy characterized by myocardial fibrosis by inhibiting the KLK8-PAR1 signaling axis.
Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis.
NOTCH1 mitochondria localization during heart development promotes mitochondrial metabolism and the endothelial-to-mesenchymal transition in mice.
Ulinastatin attenuates renal fibrosis by regulating AMPK/HIF-1α signaling pathway-mediated glycolysis.
Mechanics-activated fibroblasts promote pulmonary group 2 innate lymphoid cell plasticity propelling silicosis progression.
Extracellular matrix protein 1 binds to connective tissue growth factor against liver fibrosis and ductular reaction.
Gaudichaudione H ameliorates liver fibrosis and inflammation by targeting NRF2 signaling pathway.
Synergistic anticancer effects of ginsenoside CK and gefitinib against gefitinib-resistant NSCLC by regulating the balance of angiogenic factors through HIF-1α/VEGF.
Mangiferin alleviates diabetic pulmonary fibrosis in mice via inhibiting endothelial-mesenchymal transition through AMPK/FoxO3/SIRT3 axis.
Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis.
Dihydrocapsaicin suppresses the STING-mediated accumulation of ROS and NLRP3 inflammasome and alleviates apoptosis after ischemia-reperfusion injury of perforator skin flap.
Lacosamide alleviates bilateral cavernous nerve injury-induced erectile dysfunction in the rat model by ameliorating pathological changes in the corpus cavernosum.
The Jagged-1/Notch1 Signaling Pathway Promotes the Construction of Tissue-Engineered Heart Valves.
Sirt7/HIC1 complex participates in hyperglycaemia-mediated EndMT via modulation of SDC1 expression in diabetic kidney disease and metabolic memory.
Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid-derived suppressor cells.
Analysis of the effects of M2 macrophage-derived PDE4C on the prognosis, metastasis and immunotherapy benefit of osteosarcoma.
Inhibition of STAT3 by S3I-201 suppress peritoneal fibroblast phenotype conversion and alleviate peritoneal fibrosis.
CNPY2 governs PDGF‑BB‑treated vascular smooth muscle cell proliferation, migration and phenotypic transformation via the Akt/mTOR/GSK‑3β signaling pathway.
Riboflavin protects against pancreatic cancer metastasis by targeting TGF-β receptor 1.
Paris polyphylla ethanol extract and polyphyllin I ameliorate adenomyosis by inhibiting epithelial-mesenchymal transition.
Loss of PBX1 function in Leydig cells causes testicular dysgenesis and male sterility.
Midkine promotes renal fibrosis by stabilizing C/EBPβ to facilitate endothelial-mesenchymal transition.
Effects of Nanoparticle-Mediated Dihydromyricetin to Diabetic Wounds: An In Vivo Study.
Naringenin reduces oxidative stress and necroptosis, apoptosis, and pyroptosis in random-pattern skin flaps by enhancing autophagy.
Inhibition of OGG1 ameliorates pulmonary fibrosis via preventing M2 macrophage polarization and activating PINK1-mediated mitophagy.
Lipotoxic hepatocyte derived LIMA1 enriched small extracellular vesicles promote hepatic stellate cells activation via inhibiting mitophagy.
Senegenin Attenuates Pulmonary Fibrosis by Inhibiting Oxidative-Stress-Induced Epithelial Cell Senescence through Activation of the Sirt1/Pgc-1α Signaling Pathway.
Inducible Fgf13 ablation alleviates cardiac fibrosis via regulation of microtubule stability.
CXCL4:NLRP3-mediated pyroptosis product that regulates cardiac fibrosis.
CD47, a novel YAP target gene, contributes to hepatic stellate cell activation and liver fibrosis induced by high-fat diet.
Podocyte-Specific Deletion of MCP-1 Fails to Protect against Angiotensin II- or Adriamycin-Induced Glomerular Disease.
Exosomes derived from adipose tissue-derived stem cells alleviated H(2)O(2)-induced oxidative stress and endothelial-to-mesenchymal transition in human umbilical vein endothelial cells by inhibition of the mir-486-3p/Sirt6/Smad signaling pathway.
Astragalus polysaccharides augment BMSC homing via SDF-1/CXCR4 modulation: a novel approach to counteract peritoneal mesenchymal transformation and fibrosis.
Design, Synthesis, and Evaluation of Dihydropyrimidine Derivatives as Selective PDE1 Inhibitors for the Treatment of Liver Fibrosis.
Modeling alcohol-associated liver disease in humans using adipose stromal or stem cell-derived organoids.
MicroRNA-142-3p alleviated high salt-induced cardiac fibrosis via downregulating optineurin-mediated mitophagy.
MiRNA-145-5p inhibits gastric cancer progression via the serpin family E member 1- extracellular signal-regulated kinase-1/2 axis.
Enhanced Vascular-like Network Formation of Encapsulated HUVECs and ADSCs Coculture in Growth Factors Conjugated GelMA Hydrogels.
Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.
The SP1/SIRT1/ACLY signaling axis mediates fatty acid oxidation in renal ischemia-reperfusion-induced renal fibrosis.
SIRT1 activation ameliorates rhesus monkey liver fibrosis by inhibiting the TGF-β/smad signaling pathway.
Echinacoside Exerts Antihepatic Fibrosis Effects in High-Fat Mice Model by Modulating the ACVR2A-Smad Pathway.
Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression.
MitoQ Alleviated PM(2.5) Induced Pulmonary Epithelial Cells Injury by Inhibiting Mitochondrial-Mediated Apoptosis.
Crocin Inhibits Orbital Fibroblasts Fibrosis in Thyroid-Associated Ophthalmopathy.
TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis.
Knockdown of ARHGAP24 reduces intimal hyperplasia through inhibiting the proliferation and phenotypic switching of smooth muscle cells possibly by inactivating both AKT and ERK1/2 signaling pathways.
Integrin β8 prevents pericyte-myofibroblast transition and renal fibrosis through inhibiting the TGF-β1/TGFBR1/Smad3 pathway in diabetic kidney disease.
Arctium lappa L. polysaccharides enhanced the therapeutic effects of nasal ectomesenchymal stem cells against liver fibrosis by inhibiting the Wnt/β-catenin pathway.
Primary cilia are critical for tracheoesophageal septation.
Machine learning and single-cell transcriptome profiling reveal regulation of fibroblast activation through THBS2/TGFβ1/P-Smad2/3 signalling pathway in hypertrophic scar.
Natural intestinal metabolite xylitol reduces BRD4 levels to mitigate renal fibrosis.
Structure-based design and synthesis of anti-fibrotic compounds derived from para-positioned 3,4,5-trisubstituted benzene.
Bacterial Cellulose-Based Bandages with Integrated Antibacteria and Electrical Stimulation for Advanced Wound Management.
LATS2 degradation promoted fibrosis damage and rescued by vitamin K3 in lupus nephritis.
Network pharmacology and transcriptomic profiling elucidate the therapeutic effects of Ranunculus ternatus Thunb on liver fibrosis via MK3-NF-κB inhibition.
Macrophage-derived exosomal HMGB3 regulates silica-induced pulmonary inflammation by promoting M1 macrophage polarization and recruitment.
Spinosin inhibits activated hepatic stellate cell to attenuate liver fibrosis by targeting Nur77/ASK1/p38 MAPK signaling pathway.
Augmentation of scleral glycolysis promotes myopia through histone lactylation.
Early-life ruminal microbiome-derived indole-3-carboxaldehyde and prostaglandin D2 are effective promoters of rumen development.
Tryptanthrin promotes pressure ulcers healing in mice by inhibiting macrophage-mediated inflammation via cGAS/STING pathways.
Curculigoside Attenuates Endoplasmic Reticulum Stress-Induced Epithelial Cell and Fibroblast Senescence by Regulating the SIRT1-P300 Signaling Pathway.
Increased extracellular matrix stiffness regulates myofibroblast transformation through induction of autophagy-mediated Kindlin-2 cytoplasmic translocation.
The mechanisms and therapeutic potential of clopidogrel in mitigating diabetic cardiomyopathy in db/db mice.
Cancer-associated fibroblast-secreted FGF7 as an ovarian cancer progression promoter.
Nitric oxide nano-reactor DNMF/PLGA enables tumor vascular microenvironment and chemo-hyperthermia synergetic therapy.
Bicyclol alleviates obesity-induced renal injury by inhibiting JNK and NF-κB-mediated inflammation.
Fibroblast-Specific Depletion of Human Antigen R Alleviates Myocardial Fibrosis Induced by Cardiac Stress.
Generation of a human induced pluripotent stem cell line harboring heteroplasmic m.3243A > G mutation in MT-TL1 gene.
Bioresponsive nanocomplex integrating cancer-associated fibroblast deactivation and immunogenic chemotherapy for rebuilding immune-excluded tumors.
A 3D spheroid model of quadruple cell co-culture with improved liver functions for hepatotoxicity prediction.
Stiffened tumor microenvironment enhances perineural invasion in breast cancer via integrin signaling.
TRPC6 Knockout Alleviates Renal Fibrosis through PI3K/AKT/GSK3B Pathway.
Cancer associated fibroblast secreted miR-432-5p targets CHAC1 to inhibit ferroptosis and promote acquired chemoresistance in prostate cancer.
Dihydromyricetin alleviates inflammatory bowel disease associated intestinal fibrosis by inducing autophagy through the PI3K/AKT/mTOR signaling pathway.
Eosinophil peroxidase promotes bronchial epithelial cells to secrete asthma-related factors and induces the early stage of airway remodeling.
CILP2 promotes hypertrophic scar through Snail acetylation by interaction with ACLY.
Bile acids induce liver fibrosis through the NLRP3 inflammasome pathway and the mechanism of FXR inhibition of NLRP3 activation.
Hsa_circ_0004214 involved in the epithelial-mesenchymal transition induced by beryllium sulfate through modulating JAK-STAT signaling pathway.
microRNA-125b-1-3p mediates autophagy via the RRAGD/mTOR/ULK1 signaling pathway and mitigates atherosclerosis progression.
Fraxinellone alleviates colitis-related intestinal fibrosis by blocking the circuit between PD-1(+) Th17 cells and fibroblasts.
Extracellular vesicles activated cancer-associated fibroblasts promote lung cancer metastasis through mitophagy and mtDNA transfer.
Deciphering the molecular nexus of BTG2 in periodontitis and diabetic kidney disease.
Bioactive compound schaftoside from Clinacanthus nutans attenuates acute liver injury by inhibiting ferroptosis through activation the Nrf2/GPX4 pathway.
Multiomic analysis of monocyte-derived alveolar macrophages in idiopathic pulmonary fibrosis.
PGC1-Alpha/Sirt3 Signaling Pathway Mediates the Anti-Pulmonary Fibrosis Effect of Hirudin by Inhibiting Fibroblast Senescence.
Mesenchymal stem cells-extracellular vesicles alleviate pulmonary fibrosis by regulating immunomodulators.
Single-cell transcriptome profiling highlights the importance of telocyte, kallikrein genes, and alternative splicing in mouse testes aging.
Improved Cell Adhesion on Self-Assembled Chiral Nematic Cellulose Nanocrystal Films.
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis.
Nrf2 mediates the effects of shionone on silica-induced pulmonary fibrosis.
Graphene Far-Infrared Irradiation Can Effectively Relieve the Blood Pressure Level of Rat Untr-HT in Primary Hypertension.
Processing of angiocrine alarmin IL-1α in endothelial cells promotes lung and liver fibrosis.
EHHADH deficiency regulates pexophagy and accelerates tubulointerstitial injury in diabetic kidney disease.
Xinbao Pill ameliorates heart failure via regulating the SGLT1/AMPK/PPARα axis to improve myocardial fatty acid energy metabolism.
Alantolactone attenuates high-fat diet-induced inflammation and oxidative stress in non-alcoholic fatty liver disease.
Amelioration of NAFLD by sleeve gastrectomy-triggered hepatocyte regeneration in mice - experimental research.
Carnosol prevents cardiac remodeling and ventricular arrhythmias in pressure overload-induced heart failure mice.
Silibinin attenuates TGF-β2-induced fibrogenic changes in human trabecular meshwork cells by targeting JAK2/STAT3 and PI3K/AKT signaling pathways.
Resistance exercise upregulates Irisin expression and suppresses myocardial fibrosis following myocardial infarction via activating AMPK-Sirt1 and inactivating TGFβ1-Smad2/3.
The dual role of 20(S)-protopanaxadiol in alleviating pulmonary fibrosis through the gut-lung axis.
Repair potential of self-assembling peptide hydrogel in a mouse model of anterior cruciate ligament reconstruction.
Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos.
Arctigenin induces activated HSCs quiescence via AMPK-PPARγ pathway to ameliorate liver fibrosis in mice.
Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps.
Sestrin2 Restricts Endothelial-to-Mesenchymal Transition Induced by Lipolysaccharide via Autophagy.
The miR-15b-5p/miR-379-3p-FOXO axis regulates cell cycle and apoptosis in scleral remodeling during experimental myopia.
Inhibition of N-acetylglucosaminyltransferase V alleviates diabetic cardiomyopathy in mice by attenuating cardiac hypertrophy and fibrosis.
DKK1 loss promotes endometrial fibrosis via autophagy and exosome-mediated macrophage-to-myofibroblast transition.
Fabrication of heterocellular spheroids with controllable core-shell structure using inertial focusing effect for scaffold-free 3D cell culture models.
Zhen-wu-tang protects against myocardial fibrosis by inhibiting M1 macrophage polarization via the TLR4/NF-κB pathway.
Endothelial progenitor cells control remodeling of uterine spiral arteries for the establishment of utero-placental circulation.
CXCL3/TGF-β-mediated crosstalk between CAFs and tumor cells augments RCC progression and sunitinib resistance.
Polystyrene nanoplastics exposure causes erectile dysfunction in rats.
Isorhamnetin inhibits hypertrophic scar formation through TGF-β1/Smad and TGF-β1/CREB3L1 signaling pathways.
The ANGPTL4-HIF-1α loop: a critical regulator of renal interstitial fibrosis.
PEX3 promotes regenerative repair after myocardial injury in mice through facilitating plasma membrane localization of ITGB3.
Targeting of G protein-coupled receptor 39 alleviates angiotensin II-induced renal damage by reducing ribonucleotide reductase M2.
Loss of STARD13 contributes to aggressive phenotype transformation and poor prognosis in papillary thyroid carcinoma.
YTHDC1 delays cellular senescence and pulmonary fibrosis by activating ATR in an m6A-independent manner.
Uric acid promotes interleukin-17 expression to cause kidney injury.
A responsive hydrogel modulates innate immune cascade fibrosis to promote ocular surface reconstruction after chemical injury.
Chitosan-based oral nanoparticles as an efficient platform for kidney-targeted drug delivery in the treatment of renal fibrosis.
A hyaluronic acid / chitosan composite functionalized hydrogel based on enzyme-catalyzed and Schiff base reaction for promoting wound healing.
AT1R autoantibody promotes phenotypic transition of smooth muscle cells by activating AT1R-OAS2.
Overexpression of Corin Ameliorates Kidney Fibrosis through Inhibition of Wnt/β-Catenin Signaling in Mice.
Melatonin inhibits fibroblast cell functions and hypertrophic scar formation by enhancing autophagy through the MT2 receptor-inhibited PI3K/Akt /mTOR signaling.
Inhibition of TGFβ1 activation prevents radiation-induced lung fibrosis.
Quantitative Analysis of the Concentration of Trifluridine in Tumor Hypoxic Regions Using a Novel Platform Combining Functional Endoscopy and Mass Spectrometry.
Metabolomics reveals that chronic restraint stress alleviates carbon tetrachloride-induced hepatic fibrosis through the INSR/PI3K/AKT/AMPK pathway.
Diosmin ameliorates renal fibrosis through inhibition of inflammation by regulating SIRT3-mediated NF-κB p65 nuclear translocation.
Combination of mangiferin and T0901317 targeting autophagy promotes cholesterol efflux from macrophage foam cell in atherosclerosis.
Menstrual blood-derived stem cells exosomal miR-let-7 to ameliorate pulmonary fibrosis through inhibiting ferroptosis by Sp3/HDAC2/Nrf2 signaling pathway.
Lactate accumulation induced by Akt2-PDK1 signaling promotes pulmonary fibrosis.
MicroRNA miR-181d-5p regulates the MAPK signaling pathway by targeting mitogen-activated protein kinase 8 (MAPK8) to improve lupus nephritis.
The anti-liver fibrosis effect of Tibetan medicine (Qiwei Tiexie capsule) is related to the inhibition of NLRP3 inflammasome activation in vivo and in vitro.
Phthalides from the rhizome of Ligusticum chuanxiong Hort. attenuate diabetic nephropathy in mice.
Quercetin inhibits mesothelial-mesenchymal transition and alleviates postoperative peritoneal adhesions by blocking the TGF-β1/PI3K/AKT pathway.
S100A8/A9 promotes endometrial fibrosis via regulating RAGE/JAK2/STAT3 signaling pathway.
Cancer-associated fibroblast-derived extracellular vesicles promote lymph node metastases in oral cavity squamous cell carcinoma by encapsulating ITGB1 and BMI1.
Self-assembled coating with a metal-polyphenolic network for intraocular lens modification to prevent posterior capsule opacification.
The SIRT1/Nrf2 signaling pathway mediates the anti-pulmonary fibrosis effect of liquiritigenin.
Phomopsterone B Alleviates Liver Fibrosis through mTOR-Mediated Autophagy and Apoptosis Pathway.
Rehmannia glutinosa Libosch and Cornus officinalis Sieb herb couple ameliorates renal interstitial fibrosis in CKD rats by inhibiting the TGF-β1/MAPK signaling pathway.
Network pharmacology, molecular docking and experimental verification of the mechanism of huangqi-jixuecao herb pair in treatment of peritoneal fibrosis.
PRMT3 methylates HIF-1α to enhance the vascular calcification induced by chronic kidney disease.
Claudin-18.2 mediated interaction of gastric Cancer cells and Cancer-associated fibroblasts drives tumor progression.
Hydrogen sulfide attenuates atherosclerosis induced by low shear stress by sulfhydrylating endothelium NFIL3 to restrain MEST mediated endothelial mesenchymal transformation.
Oncostatin M/Oncostatin M Receptor Signal Induces Radiation-Induced Heart Fibrosis by Regulating SMAD4 in Fibroblast.
Establishment of an immortalized cell line derived from human adenomyosis ectopic lesions.
Costunolide attenuates high-fat diet-induced inflammation and oxidative stress in non-alcoholic fatty liver disease.
IRF4 Participates in Pulmonary Fibrosis Induced by Silica Particles through Regulating Macrophage Polarization and Fibroblast Activation.
hPMSCs Regulate the Level of TNF-α and IL-10 in Th1 Cells and Improve Hepatic Injury in a GVHD Mouse Model via CD73/ADO/Fyn/Nrf2 Axis.
Microplastics cause hepatotoxicity in diabetic mice by disrupting glucolipid metabolism via PP2A/AMPK/HNF4A and promoting fibrosis via the Wnt/β-catenin pathway.
An Injectable Composite Hydrogel of Verteporfin-Bonded Carboxymethyl Chitosan and Oxidized Sodium Alginate Facilitates Scarless Full-Thickness Skin Regeneration.
The transformation of multifunctional bio-patch to hydrogel on skin wounds for efficient scarless wound healing.
Transcription factor c-Maf drives macrophages to promote hypertrophic scar formation.
BRG1 enhances porcine iPSC pluripotency through WNT/β-catenin and autophagy pathways.
Alleviative Effect of Lactoferrin Interventions Against the Hepatotoxicity Induced by Titanium Dioxide Nanoparticles.
Downregulation of TET2 Contributes to Nasal Polypogenesis Through Hypoxia-Inducible Factor 1α-Mediated Epithelial-to-Mesenchymal Transition.
Identification of (E)-1-((1H-indol-3-yl)methylene)-4-substitute-thiosemicarbazones as potential anti-hepatic fibrosis agents.
Discovery of PRDM16-Mediated TRPA1 Induction as the Mechanism for Low Tubulo-Interstitial Fibrosis in Diabetic Kidney Disease.
Wearable bioadhesive ultrasound shear wave elastography.
The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3.
Endothelial Robo4 suppresses endothelial-to-mesenchymal transition induced by irradiation and improves hematopoietic reconstitution.
Galectin-3 is involved in inflammation and fibrosis in arteriogenic erectile dysfunction via the TLR4/MyD88/NF-κB pathway.
Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence.
Prostacyclin Mitigates Renal Fibrosis by Activating Fibroblast Prostaglandin I 2 Receptor.
C1q/tumor necrosis factor-related protein-6 suppresses the angiotensin II-induced differentiation of cardiac fibroblasts to myofibroblasts via activation of the AMPK pathway.
Up-regulation of long non-coding RNA H19 ameliorates renal tubulointerstitial fibrosis by reducing lipid deposition and inflammatory response through regulation of the microRNA-130a-3p/long-chain acyl-CoA synthetase 1 axis.
Bleomycin induces endothelial cell pyroptosis and regulates fibrosis by activating the NLRP3/caspase-1/GSDMD pathway: a possible mechanism contributing to the sclerotherapy of venous malformations.
[(18)F]AlF-CBP imaging of type I collagen for non-invasive monitoring of pulmonary fibrosis in preclinical models.
Chronic exposure to polystyrene microplastics induces renal fibrosis via ferroptosis.
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease.
Krüppel-like factor 4 modulates the miR-101/COL10A1 axis to inhibit renal fibrosis after AKI by regulating epithelial-mesenchymal transition.
Aristolochic acid I promotes renal tubulointerstitial fibrosis by up-regulating expression of indoleamine 2,3-dioxygenase-1 (IDO1).
Pachymic acid ameliorates bleomycin-induced pulmonary fibrosis through inhibiting endoplasmic reticulum stress in rats.
Engineering of phosphatidylserine-targeting ROS-responsive polymeric prodrug for the repair of ischemia-reperfusion-induced acute kidney injury.
Aryl Hydrocarbon Receptor Alleviates Hepatic Fibrosis by Inducing Hepatic Stellate Cell Ferroptosis.
Spatial dimension cues derived from fibrous scaffolds trigger mechanical activation to potentiate the paracrine and regenerative functions of MSCs via the FAK-PI3K/AKT axis.
Sec13 promotes glycolysis by inhibiting Ubqln1 mediated Pgm1 ubiquitination in ALI.
The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination.
The role and mechanism of P2X7R in cirrhotic cardiomyopathy.
Sodium cromoglycate exerts anti-pulmonary fibrosis effects by targeting the Keap1 protein to activate Nrf2 signaling.
The mechanism of α2-macroglobulin against oxidative stress and promoting cell proliferation in intervertebral disc degeneration.
Green tea polyphenol alleviates silica particle-induced lung injury by suppressing IL-17/NF-κB p65 signaling-driven inflammation.
Suyin Detoxification Granule alleviates trimethylamine N-oxide-induced tubular ferroptosis and renal fibrosis to prevent chronic kidney disease progression.
Jia Wei Qingxin Lotus Seed Drink ameliorates epithelial mesenchymal transition injury in diabetic kidney disease via inhibition of JMJD1C/SP1/ZEB1 signaling pathway.
Myricetin ameliorates airway inflammation and remodeling in asthma by activating Sirt1 to regulate the JNK/Smad3 pathway.
β-sitosterol alleviates pulmonary arterial hypertension by altering smooth muscle cell phenotype and DNA damage/cGAS/STING signaling.
Chlorogenic acid alleviate kidney fibrosis through regulating TLR4/NF-қB mediated oxidative stress and inflammation.
Skeletal muscle-derived musclin attenuates glycolysis, oxidative stress, and pulmonary hypertension through the NPR3/AKT/mTORC1 pathway.
Transcriptional landscape and predictive potential of long noncoding RNAs in peritoneal recurrence of gastric cancer.
Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM.
Dual rectification of metabolism abnormality in pancreatic cancer by a programmed nanomedicine.
Intervention effect of regulating GABA-A receptor activity on the formation of experimental abdominal aortic aneurysm in rats.
Hypoxia-induced TPC2 transcription and glycosylation aggravates pulmonary arterial hypertension by blocking autophagy flux.
Notoginsenoside R1-Protocatechuic aldehyde reduces vascular inflammation and calcification through increasing the release of nitric oxide to inhibit TGFβR1-YAP/TAZ pathway in vascular smooth muscle cells.
The bach1/G9a/Slc7a11 axis epigenetically promotes renal fibrosis by mediated ferroptosis.
Human umbilical cord mesenchymal stem cells enhance liver regeneration and decrease collagen content in fibrosis mice after partial hepatectomy by activating Wnt/β-catenin signaling.
Identification of key mitochondria-related genes and their potential crosstalk role with immune pattern in Idiopathic pulmonary fibrosis.
CD146⁺ Endothelial Cells Facilitate Renal Interstitial Fibrosis Through Endothelial-to-Mesenchymal Transition.
Pharmacodynamic insights into maresin 1: Enhancing flap viability via the keap1/Nrf2 axis to control ROS-driven apoptosis and ferroptosis.
TGFβ2 mediates oxidative stress-induced epithelial-to-mesenchymal transition of bladder smooth muscle.
Lycorine relieves the CCl(4)-induced liver fibrosis mainly via the JAK2/STAT3 and PI3K/AKT signaling pathways.
Serum deprivation protein response intervenes in the proliferation, motility, and extracellular matrix production in keloid fibroblasts by blocking the amplification of TGF-β1/SMAD signal cascade via ERK1/2.
A novel protein encoded by circLARP1B promotes the proliferation and migration of vascular smooth muscle cells by suppressing cAMP signaling.
Macroscopic and histological examination of human bridging veins.
Polydatin attenuates diabetic renal inflammatory fibrosis via the inhibition of STING pathway.
Aldehyde Dehydrogenase 2 Deficiency Aggravates Lung Fibrosis through Mitochondrial Dysfunction and Aging in Fibroblasts.
Changes in PI3K/AKT and NRF2/HO-1 signaling expression and intestinal microbiota in bleomycin-induced pulmonary fibrosis.
Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin damage repair after burn injury.
Tea polyphenol nanoparticles enable targeted siRNA delivery and multi-bioactive therapy for abdominal aortic aneurysms.
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis.
Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer.
Titanium nanoparticles released from orthopedic implants induce muscle fibrosis via activation of SNAI2.
Deficiency of flavin-containing monooxygenase 3 protects kidney function after ischemia-reperfusion in mice.
Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta.
Cryptotanshinone alleviates liver fibrosis via inhibiting STAT3/CPT1A-dependent fatty acid oxidation in hepatic stellate cells.
Role of gut microbiota in Crohn's disease pathogenesis: Insights from fecal microbiota transplantation in mouse model.
The SGLT2 inhibitor dapagliflozin ameliorates renal fibrosis in hyperuricemic nephropathy.
miR-450a-2-3p targets ERK(1/2) to ameliorate ISO-induced cardiac fibrosis in mice.
The role and mechanism of thrombospondin-4 in pulmonary arterial hypertension associated with congenital heart disease.
Catalpol inhibits HHcy-induced EndMT in endothelial cells by modulating ROS/NF-κB signaling.
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
Dexamethasone induces trabecular meshwork cell myofibroblast transdifferentiation through ARHGEF26.
The antihypertensive effect of Alizarin is achieved by activating VEGFR2/eNOS pathway, attenuating oxidative stress-induced mitochondrial damage and premature senescence.
A novel PDGFR inhibitor WQ-C-401 prevents pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension.
Asprosin contributes to vascular remodeling in hypertensive rats via superoxide signaling.
Generation of human induced pluripotent stem cell line from a patient with restrictive cardiomyopathy.
Endothelial H(2)S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis.
Exosomes derived from bone marrow mesenchymal stem cells alleviate biliary ischemia reperfusion injury in fatty liver transplantation by inhibiting ferroptosis.
DsbA-L ameliorates renal aging and renal fibrosis by maintaining mitochondrial homeostasis.
BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway.
Bone morphogenetic protein 6 (BMP6) antagonises experimental proliferative vitreoretinopathy established by TGF-β2 stimulation in retinal pigment epithelial cells through modulation of the p38 and JNK MAPK pathways.
M2 macrophage-derived paracrine factor TNFSF13 affects the fibrogenic alterations in endothelial cells and cardiac fibroblasts by mediating the NF-κB and Akt pathway.
Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease.
Antler thymosin β10 reduces liver fibrosis via inhibiting TGF-β1/SMAD pathway.
Polyvinyl alcohol/carboxymethyl chitosan-based hydrogels loaded with taxifolin liposomes promote diabetic wound healing by inhibiting inflammation and regulating autophagy.
Antibiotic bone cement accelerates diabetic foot wound healing: Elucidating the role of ROCK1 protein expression.
Cellular nucleic acid binding protein facilitates cardiac repair after myocardial infarction by activating β-catenin signaling.
Icariin alleviates diabetic renal interstitial fibrosis aggravation by inhibiting miR-320a-3p targeting BMP6.
CXCL4/CXCR3 axis regulates cardiac fibrosis by activating TGF-β1/Smad2/3 signaling in mouse viral myocarditis.
Low-Frequency Ultrasound Sensitive Piezo1 Channels Regulate Keloid-Related Characteristics of Fibroblasts.
PI3Kδ Mediates Fibrosis by Patient-Derived Vitreous.
NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin.
Global proteomic analysis reveals lysine succinylation is involved in the pathogenesis of hypertrophic scar.
DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis.
ACAT2 suppresses the ubiquitination of YAP1 to enhance the proliferation and metastasis ability of gastric cancer via the upregulation of SETD7.
SirT7-mediated transcription of fascin in hyperglycemic glomerular endothelial cells contributes to EndMT in diabetic nephropathy.
Jin-Gui-Shen-Qi Wan alleviates fibrosis in mouse diabetic nephropathy via MHC class II.
Leech extract alleviates idiopathic pulmonary fibrosis by TGF-β1/Smad3 signaling pathway.
Baicalein alleviates intrahepatic cholestasis by regulating bile acid metabolism via an FXR-dependent manner.
AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis.
Human Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Alleviate Hypoxia-Induced Pulmonary Arterial Hypertension in Mice Via Macrophages.
Improving impact of heparan sulfate on the endothelial glycocalyx abnormalities in atherosclerosis as revealed by glycan-protein interactome.
Incorporating machine learning and PPI networks to identify mitochondrial fission-related immune markers in abdominal aortic aneurysms.
FBXL8 inhibits post-myocardial infarction cardiac fibrosis by targeting Snail1 for ubiquitin-proteasome degradation.
Patient-Derived Exosomes as siRNA Carriers in Ovarian Cancer Treatment.
Liquiritigenin Attenuated Collagen-Induced Arthritis and Cardiac Complication via Inflammation and Fibrosis Inhibition in Mice.
Trimethylamine N-oxide Promotes Atherosclerosis by Regulating Low-Density Lipoprotein-Induced Autophagy in Vascular Smooth Muscle Cells Through PI3K/AKT/mTOR Pathway.
Isolation and Cultivation of Vascular Smooth Muscle Cells from the Mouse Circle of Willis.
Echinacoside alleviates airway remodeling and inflammation in an ovalbumin-induced neonatal mouse model of asthma by modulating the SIRT1-NF-κB pathway.
Propofol improves ischemia reperfusion-induced liver fibrosis by regulating lncRNA HOXA11-AS.
Chlorogenic Acid Inhibited Epithelial-Mesenchymal Transition to Treat Pulmonary Fibrosis through Modulating Autophagy.
Indirubin alleviates CCl(4)-induced liver fibrosis by regulation of TGF-β-mediated signaling pathways.
Up-regulated SPP1 increases the risk from IPF to lung cancer via activating the pro-tumor macrophages.
miR-145 Alleviates Smooth Muscle Cell Phenotype Transition via ADAM17-Mediated ACE2 Shedding.
hucMSC-Ex Alleviates IBD-Associated Intestinal Fibrosis by Inhibiting ERK Phosphorylation in Intestinal Fibroblasts.
Renalase Prevents Renal Fibrosis by Inhibiting Endoplasmic Reticulum Stress and Down-Regulating GSK-3β/Snail Signaling.
FAT10 Silencing Prevents Liver Fibrosis through Regulating SIRT1 Expression in Hepatic Stellate Cells.
Sarcoma protein kinase inhibition alleviates liver fibrosis by promoting hepatic stellate cells ferroptosis.
Adiponectin inhibits TGF-β1-induced skin fibroblast proliferation and phenotype transformation via the p38 MAPK signaling pathway.
Exosome Derived from Mesenchymal Stem Cells Alleviates Hypertrophic Scar by Inhibiting the Fibroblasts via TNFSF-13/HSPG2 Signaling Pathway.
Identification and Characterization of a Novel Nanobody Against Human CTGF to Reveal Its Antifibrotic Effect in an in vitro Model of Liver Fibrosis.
Glycosylation-Engineered Platelet Membrane-Coated Interleukin 10 Nanoparticles for Targeted Inhibition of Vascular Restenosis.
Co-Delivery Nanomicelles for Potentiating TNBC Immunotherapy by Synergetically Reshaping CAFs-Mediated Tumor Stroma and Reprogramming Immunosuppressive Microenvironment.
Irisin Ameliorates Renal Tubulointerstitial Fibrosis by Regulating the Smad4/β-Catenin Pathway in Diabetic Mice.
GLIS2 Prevents Hepatic Fibrosis by Competitively Binding HDAC3 to Inhibit Hepatic Stellate Cell Activation.
Mannan-Binding Lectin Reduces Epithelial-Mesenchymal Transition in Pulmonary Fibrosis via Inactivating the Store-Operated Calcium Entry Machinery.
A comprehensive cuproptosis score and associated gene signatures reveal prognostic and immunological features of idiopathic pulmonary fibrosis.
Four novel mutations identification in 17 beta-hydroxysteroid dehydrogenase-3 deficiency and our clinical experience: possible benefits of early treatment.
Tangeretin attenuates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition via the PI3K/Akt pathway.
The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy.
APOC1 exacerbates renal fibrosis through the activation of the NF-κB signaling pathway in IgAN.
The role of the SGK3/TOPK signaling pathway in the transition from acute kidney injury to chronic kidney disease.
Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish.
Apolipoprotein A-I attenuates peritoneal fibrosis associated with peritoneal dialysis by inhibiting oxidative stress and inflammation.
IL-12α deficiency attenuates pressure overload-induced cardiac inflammation, hypertrophy, dysfunction, and heart failure progression.
Aqueous extract of Amydrium sinense (Engl.) H. Li alleviates hepatic fibrosis by suppressing hepatic stellate cell activation through inhibiting Stat3 signaling.
A strategy of local hydrogen capture and catalytic hydrogenation for enhanced therapy of chronic liver diseases.
Primary extra-gastrointestinal stromal tumor of retroperitoneum: Clinicopathologic characteristics and prognosis of six cases.
S-propargyl-cysteine promotes the stability of atherosclerotic plaque via maintaining vascular muscle contractile phenotype.
Effect of stem cell conditional medium-loading adhesive hydrogel on TGF-β1-induced endometrial stromal cell fibrosis.
Engineered exosomes derived from miR-132-overexpresssing adipose stem cells promoted diabetic wound healing and skin reconstruction.
Ketogenic diet alleviates renal fibrosis in mice by enhancing fatty acid oxidation through the free fatty acid receptor 3 pathway.
Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model.
Integrative analysis of cancer-associated fibroblast signature in gastric cancer.
Knockdown of AK142426 suppresses M2 macrophage polarization and inflammation in peritoneal fibrosis via binding to c-Jun.
SIRT3 regulates mitophagy in liver fibrosis through deacetylation of PINK1/NIPSNAP1.
Mining host candidate regulators of schistosomiasis-induced liver fibrosis in response to artesunate therapy through transcriptomics approach.
AP39 inhibits ferroptosis by inhibiting mitochondrial autophagy through the PINK1/parkin pathway to improve myocardial fibrosis with myocardial infarction.
A novel onco-cardiological mouse model of lung cancer-induced cardiac dysfunction and its application in identifying potential roles of tRNA-derived small RNAs.
miR-32-5p induces hepatic steatosis and hyperlipidemia by triggering de novo lipogenesis.
SGLT2 inhibitor empagliflozin downregulates miRNA-34a-5p and targets GREM2 to inactivate hepatic stellate cells and ameliorate non-alcoholic fatty liver disease-associated fibrosis.
Milk-derived exosomes carrying siRNA-KEAP1 promote diabetic wound healing by improving oxidative stress.
Celastrol attenuates diabetic nephropathy by upregulating SIRT1-mediated inhibition of EZH2related wnt/β-catenin signaling.
Axitinib attenuates the progression of liver fibrosis by restoring mitochondrial function.
Geniposide alleviated bile acid-associated NLRP3 inflammasome activation by regulating SIRT1/FXR signaling in bile duct ligation-induced liver fibrosis.
Mammalian cleavage factor 25 targets KLF14 to inhibit hepatic stellate cell activation and liver fibrosis.
HMGA2 knockdown alleviates the progression of nonalcoholic fatty liver disease (NAFLD) by downregulating SNAI2 expression.
TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5.
FNDC5 inhibits autophagy of bone marrow mesenchymal stem cells and promotes their survival after transplantation by downregulating Sp1.
NDUFC2 deficiency exacerbates endothelial mesenchymal transformation during ischemia-reperfusion via NLRP3.
Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation.
Exosomal miR-17-5p from human embryonic stem cells prevents pulmonary fibrosis by targeting thrombospondin-2.
The effects of Shikonin on the hypertrophic scar of rabbit ears via the TLR4/NF-κB signaling pathway.
Curcumin ameliorates focal segmental glomerulosclerosis by inhibiting apoptosis and oxidative stress in podocytes.
Dendrobium officinale Kimura & Migo polysaccharide inhibits hyperglycaemia-induced kidney fibrosis via the miRNA-34a-5p/SIRT1 signalling pathway.
The alcohol extracts of Sceptridium ternatum (Thunb.) Lyon exert anti-pulmonary fibrosis effect through targeting SETDB1/STAT3/p-STAT3 signaling.
The effect of GelDex-S58 hydrogel on anti-conjunctival scarring after glaucoma filtration surgery.
Selective inhibition of glycolysis in hepatic stellate cells and suppression of liver fibrogenesis with vitamin A-derivative decorated camptothecin micelles.
PRDX1 Cys52Ser variant alleviates nonalcoholic steatohepatitis by reducing inflammation in mice.
Chronic β-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis.
PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF-1α protein stability and gene expression.
Human-Induced Hepatocytes-Derived Extracellular Vesicles Ameliorated Liver Fibrosis in Mice Via Suppression of TGF-β1/Smad Signaling and Activation of Nrf2/HO-1 Signaling.
Niclosamide inhibits TGF-β1-induced fibrosis of human Tenon's fibroblasts by regulating the MAPK-ERK1/2 pathway.
Myeloid-specific deletion of Capns1 attenuates myocardial infarction injury via restoring mitochondrial function and inhibiting inflammasome activation.
M2 macrophages mediate fibrotic scar formation in the early stages after cerebral ischemia in rats.
Nintedanib inhibits normal human vitreous-induced epithelial-mesenchymal transition in human retinal pigment epithelial cells.
Molecular insights of a CBP/β-catenin-signaling inhibitor on nonalcoholic steatohepatitis-induced liver fibrosis and disorder.
Farnesoid X receptor activation is required for the anti-inflammatory and anti-oxidative stress effects of Alisol B 23-acetate in carbon tetrachloride-induced liver fibrosis in mice.
Hierarchically Released Liquid Metal Nanoparticles for Mild Photothermal Therapy/Chemotherapy of Breast Cancer Bone Metastases via Remodeling Tumor Stromal Microenvironment.
Sox7-positive endothelial progenitors establish coronary arteries and govern ventricular compaction.
Theaflavine inhibits hepatic stellate cell activation by modulating the PKA/LKB1/AMPK/GSK3β cascade and subsequently enhancing Nrf2 signaling.
Fu-Zheng-Tong-Luo formula promotes autophagy and alleviates idiopathic pulmonary fibrosis by controlling the Janus kinase 2/signal transducer and activator of transcription 3 pathway.
NLRP3 Inflammasome Activates Endothelial-to-Mesenchymal Transition via Focal Adhesion Kinase Pathway in Bleomycin-Induced Pulmonary Fibrosis.
CRTC2 activates the epithelial-mesenchymal transition of diabetic kidney disease through the CREB-Smad2/3 pathway.
Sodium-glucose cotransporter 2 inhibitor canagliflozin alleviates vascular calcification through suppression of nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 inflammasome.
Activation of acetyl-CoA synthetase 2 mediates kidney injury in diabetic nephropathy.
The Dual-Mode Transition of Myofibroblasts Derived from Hepatic Stellate Cells in Liver Fibrosis.
Targeting ferroptosis attenuates podocytes injury and delays tubulointerstitial fibrosis in focal segmental glomerulosclerosis.
Single-cell transcriptome profiling reveals immune and stromal cell heterogeneity in primary Sjögren's syndrome.
Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling.
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
High glucose promotes benign prostatic hyperplasia by downregulating PDK4 expression.
Vitamin D(3) analogue calcipotriol inhibits the profibrotic effects of transforming growth factor- β1 on pancreatic stellate cells.
Colchicine protects against the development of experimental abdominal aortic aneurysm.
20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings improved burn wound healing potentials.
Structural analysis and attenuates hyperuricemic nephropathy of dextran from the Imperata cylindrica Beauv. var. major (Nees) C. E. Hubb.
Mannan-binding lectin ameliorates renal fibrosis by suppressing macrophage-to-myofibroblast transition.
Pacenta polypeptide injection alleviates the fibrosis and inflammation in cigarette smoke extracts-induced BEAS-2B cells by modulating MMP-9/TIMP-1 signaling.
Single-cell analysis reveals immune cellular components in odontogenic keratocysts.
Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice.
Unleashing the healing potential: Exploring next-generation regenerative protein nanoscaffolds for burn wound recovery.
Butyrate alleviates renal fibrosis in CKD by regulating NLRP3-mediated pyroptosis via the STING/NF-κB/p65 pathway.
3D Prestress Bioprinting of Directed Tissues.
Silk Acid as an Implantable Biomaterial for Tissue Regeneration.
Caveolin-1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease.
Schisandrin B Alleviates Renal Tubular Cell Epithelial-Mesenchymal Transition and Mitochondrial Dysfunction by Kielin/Chordin-like Protein Upregulation via Akt Pathway Inactivation and Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase Pathway Activation in Diabetic Kidney Disease.
Extracellular vesicle-derived silk fibroin nanoparticles loaded with MFGE8 accelerate skin ulcer healing by targeting the vascular endothelial cells.
A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis in mice via binding and relocating acetyl-coA carboxylase.
Netrin-1 feedforward mechanism promotes pancreatic cancer liver metastasis via hepatic stellate cell activation, retinoid, and ELF3 signaling.
Precisely Regulating M2 Subtype Macrophages for Renal Fibrosis Resolution.
Four-dimensional hydrogel dressing adaptable to the urethral microenvironment for scarless urethral reconstruction.
RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment.
FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression.
Exosomes derived from cardiac fibroblasts with angiotensin II stimulation provoke hypertrophy and autophagy inhibition in cardiomyocytes.
MircroRNA-92b as a negative regulator of the TGF-β signaling by targeting the type I receptor.
A role of TRIM59 in pulmonary hypertension: modulating the protein ubiquitylation modification.
Gracillin relieves pulmonary fibrosis by suppressing the STAT3 axis.
Circ_16601 facilitates Hippo pathway signaling via the miR-5580-5p/FGB axis to promote my-CAF recruitment in the TME and LUAD progression.
Electroacupuncture alleviates intrauterine adhesion through regulating autophagy in rats.
cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis.
Folic acid supplementation rescues bladder injury in fetal rats with myelomeningocele.
Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction.
Dihydroartemisinin inhibits the activation and proliferation of hepatic stellate cells by regulating miR‑29b‑3p.
Prolonged exposure to the herbicide atrazine promotes kidney fibrosis by activating Wnt/β-catenin signaling in rats.
Liver sinusoidal endothelial S1pr2 regulates experimental liver fibrosis through YAP/TGF-β signaling pathway.
CircRNA_0017076 acts as a sponge for miR-185-5p in the control of epithelial-to-mesenchymal transition of tubular epithelial cells during renal interstitial fibrosis.
Lycopene inhibits endothelial-to-mesenchymal transition of choroidal vascular endothelial cells in laser-induced mouse choroidal neovascularization.
Ambient particulate matter exposure plus chronic ethanol ingestion exacerbates hepatic fibrosis by triggering the mitochondrial ROS-ferroptosis signaling pathway in mice.
A multifunctional neuromodulation platform utilizing Schwann cell-derived exosomes orchestrates bone microenvironment via immunomodulation, angiogenesis and osteogenesis.
Inhibitory effect of miR-138-5p on choroidal fibrosis in lens-induced myopia guinea pigs via suppressing the HIF-1α signaling pathway.
Nintedanib prevents TGF-β2-induced epithelial-mesenchymal transition in retinal pigment epithelial cells.
Nr4a1 promotes renal interstitial fibrosis by regulating the p38 MAPK phosphorylation.
Cryptotanshinone induces apoptosis of activated hepatic stellate cells via modulating endoplasmic reticulum stress.
EPAS1 prevents telomeric damage-induced senescence by enhancing transcription of TRF1, TRF2, and RAD50.
Ginsenoside Rb1 promotes the activation of PPARα pathway via inhibiting FADD to ameliorate heart failure.
Aristolocholic acid I promotes renal tubular epithelial fibrosis by upregulating matrix metalloproteinase-9 expression via activating the C3a/C3aR axis of macrophages.
Development and validation of a radiomics model of magnetic resonance for predicting liver metastasis in resectable pancreatic ductal adenocarcinoma patients.
The p53/miR-29a-3p axis mediates the antifibrotic effect of leonurine on angiotensin II-stimulated rat cardiac fibroblasts.
Noncanonical atherosclerosis as the driving force in tricuspid aortic valve associated aneurysms - A trace collection.
Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-β receptor II.
ZD6474 Attenuates Fibrosis and Inhibits Neovascularization in Human Pterygium by Suppressing AKT-mTOR Signaling Pathway.
m(6)A methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic fibrosis.
CCN2/CTGF promotes liver fibrosis through crosstalk with the Slit2/Robo signaling.
Deletion of LCMR1 in alveolar type II cells induces lethal impairment of lung structure and function in adult mice.
Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis.
Curcumol suppresses endothelial-to-mesenchymal transition via inhibiting the AKT/GSK3β signaling pathway and alleviates pulmonary arterial hypertension in rats.
Benzylisoquinoline alkaloids inhibit lung fibroblast activation mainly via inhibiting TGF-β1/Smads and ERK1/2 pathway proteins.
FAM3A mediates the phenotypic switch of human aortic smooth muscle cells stimulated with oxidised low-density lipoprotein by influencing the PI3K-AKT pathway.
Collagen Triple Helix Repeat Containing 1 Deficiency Protects Against Airway Remodeling and Inflammation in Asthma Models In Vivo and In Vitro.
Efficacy of Danggui Buxue decoction on diabetic nephropathy-induced renal fibrosis in rats and possible mechanism.
A novel tetra-PEG based hydrogel for prevention of esophageal stricture after ESD in a porcine model.
Protective effects of methylprednisolone-cyclophosphamide treatment on bleomycin-induced pulmonary fibrosis.
Oroxylin A activates ferritinophagy to induce hepatic stellate cell senescence against hepatic fibrosis by regulating cGAS-STING pathway.
Inflachromene inhibits intimal hyperplasia through the HMGB1/2- regulated TLR4-NF-κB pathway.
Differences in p38-STAT3-S100A11 signaling after the administration of aristolochic acid I and IVa may account for the disparity in their nephrotoxicity.
Aloe-emodin ameliorated MI-induced cardiac remodeling in mice via inhibiting TGF-β/SMAD signaling via up-regulating SMAD7.
Silencing of NOTCH3 Signaling in Meniscus Smooth Muscle Cells Inhibits Fibrosis and Exacerbates Degeneration in a HEYL-Dependent Manner.
Time-dependent effect of REV-ERBα agonist SR9009 on nonalcoholic steatohepatitis and gut microbiota in mice.
MgIG Attenuates Oxaliplatin-induced Hepatotoxicity through Suppression of Connexin 43 in Hepatic Stellate Cells.
Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration.
Identification of potential biomarkers for idiopathic pulmonary fibrosis and validation of TDO2 as a potential therapeutic target.
Autophagy-Interfering Nanoboat Drifting along CD44-Golgi-ER Flow as RNAi Therapeutics for Hepatic Fibrosis.
Macrophage Dectin-1 mediates Ang II renal injury through neutrophil migration and TGF-β1 secretion.
ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis.
HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo.
Genetic lineage tracing reveals stellate cells as contributors to myofibroblasts in pancreas and islet fibrosis.
Scarless wound healing programmed by core-shell microneedles.
Ferroptosis in the Lacrimal Gland Is Involved in Dry Eye Syndrome Induced by Corneal Nerve Severing.
Venoarterial extracorporeal membrane oxygenation improves survival in a rat model of acute myocardial infarction.
Ginseng saponin metabolite 20(S)-protopanaxadiol relieves pulmonary fibrosis by multiple-targets signaling pathways.
Total flavonoid extract from Dracocephalum moldavica L. improves pulmonary fibrosis by reducing inflammation and inhibiting the hedgehog signaling pathway.
Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity.
Step-wise CAG@PLys@PDA-Cu(2+) modification on micropatterned nanofibers for programmed endothelial healing.
Inhibiting Heat Shock Protein 90 Attenuates Nucleus Pulposus Fibrosis and Pathologic Angiogenesis Induced by Macrophages via Down-Regulating Cell Migration-Inducing Protein.
Inhaled Lipid Nanoparticles Alleviate Established Pulmonary Fibrosis.
Fibroblast growth factor 10 delays the progression of osteoarthritis by attenuating synovial fibrosis via inhibition of IL-6/JAK2/STAT3 signaling in vivo and in vitro.
Ginkgo biloba extract attenuates cisplatin-induced renal interstitial fibrosis by inhibiting the activation of renal fibroblasts through down-regulating the HIF-1α/STAT3/IL-6 pathway in renal tubular epithelial cells.
CAFs targeted ultrasound-responsive nanodroplets loaded V9302 and GLULsiRNA to inhibit melanoma growth via glutamine metabolic reprogramming and tumor microenvironment remodeling.
Anticoagulants Enhance Molecular and Cellular Immunotherapy of Cancer by Improving Tumor Microcirculation Structure and Function and Redistributing Tumor Infiltrates.
Metformin attenuates chronic lung allograft dysfunction: evidence in rat models.
Disruption of RCAN1.4 expression mediated by YY1/HDAC2 modulates chronic renal allograft interstitial fibrosis.
Identification of TGF-β-related genes in cardiac hypertrophy and heart failure based on single cell RNA sequencing.
Achieving tissue-level softness on stretchable electronics through a generalizable soft interlayer design.
CXCL17 Attenuates Diesel Exhaust Emissions Exposure-Induced Lung Damage by Regulating Macrophage Function.
Metformin suppressed tendon injury-induced adhesion via hydrogel-nanoparticle sustained-release system.
Wen-Shen-Jian-Pi-Hua-Tan decoction protects against early obesity-related glomerulopathy by improving renal bile acid composition and suppressing lipogenesis, inflammation, and fibrosis.
Nanoengineered mesenchymal stem cell therapy for pulmonary fibrosis in young and aged mice.
Atractylenolide III Ameliorates Bile Duct Ligation-Induced Liver Fibrosis by Inhibiting the PI3K/AKT Pathway and Regulating Glutamine Metabolism.
Single-cell transcriptome sequencing-based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis.
Elevated retinal fibrosis in experimental myopia is involved in the activation of the PI3K/AKT/ERK signaling pathway.
Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer.
Ginsenoside Rg3 liposomes regulate tumor microenvironment for the treatment of triple negative breast cancer.
Imbalance in ALR ubiquitination accelerates the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma.
Quercetin inhibits the amphiregulin/EGFR signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in obstructive nephropathy.
Single-cell RNA sequencing analysis revealed cellular and molecular immune profiles in lung squamous cell carcinoma.
Spinal Cord Stimulation Attenuates Neural Remodeling, Inflammation, and Fibrosis After Myocardial Infarction.
Qing Fei Hua Xian Decoction ameliorates bleomycin-induced pulmonary fibrosis by suppressing oxidative stress through balancing ACE-AngII-AT1R/ACE2-Ang-(1-7)-Mas axis.
PD-L1 upregulation promotes drug-induced pulmonary fibrosis by inhibiting vimentin degradation.
Oroxylin A regulates cGAS DNA hypermethylation induced by methionine metabolism to promote HSC senescence.
The effects of taraxasterol on liver fibrosis revealed by RNA sequencing.
Effective-compounds of Jinshui Huanxian formula ameliorates fibroblast activation in pulmonary fibrosis by inhibiting the activation of mTOR signaling.
Yishen-Qingli-Huoxue formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling.
Elevated Angiotensin-II Levels Contribute to the Pathogenesis of Open-Angle Glaucoma Via Inducing the Expression of Fibrosis-Related Genes in Trabecular Meshwork Cells Through a ROS/NOX4/SMAD3 Axis.
N-acetylglucosamine-bearing polymers mimicking O-GlcNAc-modified proteins elicit anti-fibrotic activities in myofibroblasts and activated stellate cells.
Neuron-Glial Antigen 2 Participates in Liver Fibrosis via Regulating the Differentiation of Bone Marrow Mesenchymal Stem Cell to Myofibroblast.
Cryptotanshinone modulates proliferation, apoptosis, and fibrosis through inhibiting AR and EGFR/STAT3 axis to ameliorate benign prostatic hyperplasia progression.
Baicalin prevents fibrosis of human trabecular meshwork cells via inhibiting the MyD88/NF-κB pathway.
Facile preparation of a novel nanoemulsion based hyaluronic acid hydrogel loading with Poria cocos triterpenoids extract for wound dressing.
Increased β1-adrenergic receptor antibody confers a vulnerable substrate for atrial fibrillation via mediating Ca2+ mishandling and atrial fibrosis in active immunization rabbit models.
Biejiajian pill inhibits progression of hepatocellular carcinoma by downregulating PDGFRβ signaling in cancer-associated fibroblasts.
Exosomes derived from human adipose mesenchymal stem cells ameliorate hepatic fibrosis by inhibiting PI3K/Akt/mTOR pathway and remodeling choline metabolism.
PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation.
Orally administration of cerium oxide nanozyme for computed tomography imaging and anti-inflammatory/anti-fibrotic therapy of inflammatory bowel disease.
HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells.
Endosulfan induced kidney cell injury by modulating ACE2 through up-regulating miR-429 in HK-2 cells.
20-Hydroxytetraenoic acid induces hepatic fibrosis via the TGF-β1/Smad3 signaling pathway.
The m6A demethylase FTO promotes keloid formation by up-regulating COL1A1.
Cell-Permeable PROTAC Degraders against KEAP1 Efficiently Suppress Hepatic Stellate Cell Activation through the Antioxidant and Anti-Inflammatory Pathway.
Endoscopy Deliverable and Mushroom-Cap-Inspired Hyperboloid-Shaped Drug-Laden Bioadhesive Hydrogel for Stomach Perforation Repair.
Macrophage-derived exosomal lncRNA MSTRG.91634.7 inhibits fibroblasts activation by targeting PINK1 in silica-induced lung fibrosis.
VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice.
Type 1 diabetes mellitus leads to gingivitis and an early compensatory increase in bone remodeling.
Generation of an induced pluripotent stem cell line (IPCASi001-A) from an autism spectrum disorder individual without intellectual disability.
Deposition of platelet-derived microparticles in podocytes contributes to diabetic nephropathy.
Glycyrrhizic acid improves tacrolimus-induced renal injury by regulating autophagy.
In Situ Endothelialization of Free-Form 3D Network of Interconnected Tubular Channels via Interfacial Coacervation by Aqueous-in-Aqueous Embedded Bioprinting.
miRNA‑92a inhibits vascular smooth muscle cell phenotypic modulation and may help prevent in‑stent restenosis.
Effects of substrate topography on the regulation of human fibroblasts and capsule formation via modulating macrophage polarization.
Fc Fragment of IgE Receptor Ig (FCER1G) acts as a key gene involved in cancer immune infiltration and tumour microenvironment.
A small-molecule JNK inhibitor JM-2 attenuates high-fat diet-induced non-alcoholic fatty liver disease in mice.
Hepatic stellate cell-released CXCL1 aggravates HCC malignant behaviors through the MIR4435-2HG/miR-506-3p/TGFB1 axis.
Loss of Protein Kinase D2 Activity Protects Against Bleomycin-Induced Dermal Fibrosis in Mice.
LIM and Cysteine-Rich Domains 1 Promotes Transforming Growth Factor β1-Induced Epithelial-Mesenchymal Transition in Human Kidney 2 Cells.
Prognostic Value of CXCL12 in Non-Small Cell Lung Cancer Patients Undergoing Tumor Resection.
Secretome of hESC-Derived MSC-like Immune and Matrix Regulatory Cells Mitigate Pulmonary Fibrosis through Antioxidant and Anti-Inflammatory Effects.
BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma.
Macrophage-derived GPNMB trapped by fibrotic extracellular matrix promotes pulmonary fibrosis.
Aerobic exercise inhibits renal EMT by promoting irisin expression in SHR.
Nanodrug rescues liver fibrosis via synergistic therapy with H(2)O(2) depletion and Saikosaponin b1 sustained release.
Intermedin 1-53 Ameliorates Atrial Fibrosis and Reduces Inducibility of Atrial Fibrillation via TGF-β1/pSmad3 and Nox4 Pathway in a Rat Model of Heart Failure.
Gut microbiota and bile acids partially mediate the improvement of fibroblast growth factor 21 on methionine-choline-deficient diet-induced non-alcoholic fatty liver disease mice.
Baicalin attenuates pulmonary vascular remodeling by inhibiting calpain-1 mediated endothelial-to-mesenchymal transition.
Estrogen inhibits the differentiation of fibroblasts induced by high stiffness matrix by enhancing DNMT1 expression.
RGS1 mediates renal interstitial fibrosis through activation of the inflammatory response.
STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation.
Evaluation of topical methylene blue nanoemulsion for wound healing in diabetic mice.
Loke zupa decoction attenuates bronchial EMT-mediated airway remodelling in chronic asthma through the PI3K-Akt/HIF-1α signaling pathway.
Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription modified Shen-Yan-Fang-Shuai formula in treating diabetic nephropathy.
Increased m6A-RNA methylation and demethylase FTO suppression is associated with silica-induced pulmonary inflammation and fibrosis.
KPNA2 Silencing, Regulated by E3 Ubiquitin Ligase FBXW7, Alleviates Endothelial Dysfunction and Inflammation Through Inhibiting the Nuclear Translocation of p65 and IRF3: A Possible Therapeutic Approach for Atherosclerosis.
Human umbilical cord mesenchymal stem cell exosomes alleviate acute kidney injury by inhibiting pyroptosis in rats and NRK-52E cells.
Exoskeleton Partial-Coated Stem Cells for Infarcted Myocardium Restoring.
Vitamin D3 alleviates lung fibrosis of type 2 diabetic rats via SIRT3 mediated suppression of pyroptosis.
Polydatin alleviates bleomycin-induced pulmonary fibrosis and alters the gut microbiota in a mouse model.
Engineered muscle from micro-channeled PEG scaffold with magnetic Fe(3)O(4) fixation towards accelerating esophageal muscle repair.
Polyethylene glycol crosslinked decellularized single liver lobe scaffolds with vascular endothelial growth factor promotes angiogenesis in vivo.
Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15.
Triptolide attenuates CCL(4)-induced liver fibrosis by regulating the differentiation of CD(4)(+) T cells in mice.
BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK-1/Egr-1 axis.
Sodium alginate combined with oxymatrine ameliorates CCl(4)-induced chemical hepatic fibrosis in mice.
Tamoxifen induced cardiac damage via the IL-6/p-STAT3/PGC-1α pathway.
Isovitexin alleviates hepatic fibrosis by regulating miR-21-mediated PI3K/Akt signaling and glutathione metabolic pathway: based on transcriptomics and metabolomics.
Oleanolic acid derivative alleviates cardiac fibrosis through inhibiting PTP1B activity and regulating AMPK/TGF-β/Smads pathway.
Suppressive effect of nitric oxide synthase (NOS) inhibitor L-NMMA acetate on choroidal fibrosis in experimental myopic guinea pigs through the nitric oxide signaling pathway.
The Long non-coding RNA MALAT1 functions as a competing endogenous RNA to regulate vascular remodeling by sponging miR-145-5p/HK2 in hypertension.
Canagliflozin ameliorates hypobaric hypoxia-induced pulmonary arterial hypertension by inhibiting pulmonary arterial smooth muscle cell proliferation.
CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells.
Muscone inhibits angiotensin II-induced cardiac hypertrophy through the STAT3, MAPK and TGF-β/SMAD signaling pathways.
Exosomal ITGB6 from dormant lung adenocarcinoma cells activates cancer-associated fibroblasts by KLF10 positive feedback loop and the TGF-β pathway.
Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz (Wwtr1) Activation in Male LDLR-/- Mice.
Biodegradable nano black phosphorus based SDF1-α delivery system ameliorates Erectile Dysfunction in a cavernous nerve injury rat model by recruiting endogenous stem/progenitor cells.
A multi-functional double cross-linked chitosan hydrogel with tunable mechanical and antibacterial properties for skin wound dressing.
Anti-VEGFR2 F(ab')(2) drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy.
Hepatic Stellate Cell- and Liver Microbiome-Specific Delivery System for Dihydrotanshinone I to Ameliorate Liver Fibrosis.
The application of a novel platform of multiparametric magnetic resonance imaging in a bioenvironmental toxic carbon tetrachloride-induced mouse model of liver fibrosis.
Cell and rat serum, urine and tissue metabolomics analysis elucidates the key pathway changes associated with chronic nephropathy and reveals the mechanism of action of rhein.
Ginsenoside Rg1 Alleviates Lipopolysaccharide-Induced Fibrosis of Endometrial Epithelial Cells in Dairy Cows by Inhibiting Reactive Oxygen Species-Activated NLRP3.
＜Editors' Choice＞ Supernatant from activated omentum accelerates wound healing in diabetic mice wound model.
Dipeptidase‑2 is a prognostic marker in lung adenocarcinoma that is correlated with its sensitivity to cisplatin.
Testosterone attenuates senile cavernous fibrosis by regulating TGFβR1 and galectin-1 signaling pathways through miR-22-3p.
Salvianolic Acid B Attenuates Hypertrophic Scar Formation In Vivo and In Vitro.
sST2: A Bridge Between Sirt1/p53/p21 Signal-Induced Senescence and TGF-β1/Smad2/3 Regulation of Cardiac Fibrosis in Mouse Viral Myocarditis.
Transcription factor 21 accelerates vascular calcification in mice by activating the IL-6/STAT3 signaling pathway and the interplay between VSMCs and ECs.
Kangfuxin Accelerates Extraction Socket Healing by Promoting Angiogenesis Via Upregulation of CCL2 in Stem Cells.
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
Sustained release of magnesium and zinc ions synergistically accelerates wound healing.
Crosstalk between Interleukin-1 Receptor-Like 1 and Transforming Growth Factor-β Receptor Signaling Promotes Renal Fibrosis.
p53 deacetylation alleviates calcium oxalate deposition-induced renal fibrosis by inhibiting ferroptosis.
Ginsenoside Rg1 ameliorates hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and inflammation by regulating CCN1.
Genetic and pharmacological inhibition of METTL3 alleviates renal fibrosis by reducing EVL m6A modification through an IGF2BP2-dependent mechanism.
Amelioratory effects of astragaloside IV on hepatocarcinogenesis via Nrf2-mediated pSmad3C/3L transformation.
Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancer.
NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.
N-acetyltransferase 10 promotes cutaneous wound repair via the NF-κB-IL-6 axis.
Baricitinib improves pulmonary fibrosis in mice with rheumatoid arthritis-associated interstitial lung disease by inhibiting the Jak2/Stat3 signaling pathway.
CXCL8 Promotes Endothelial-to-Mesenchymal Transition of Endothelial Cells and Protects Cells from Erastin-Induced Ferroptosis via CXCR2-Mediated Activation of the NF-κB Signaling Pathway.
Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis.
Exosomal miR-103a-3p from Crohn's Creeping Fat-Derived Adipose-Derived Stem Cells Contributes to Intestinal Fibrosis by Targeting TGFBR3 and Activating Fibroblasts.
UCP1 alleviates renal interstitial fibrosis progression through oxidative stress pathway mediated by SIRT3 protein stability.
Carcinoma-associated fibroblast-derived lysyl oxidase-rich extracellular vesicles mediate collagen crosslinking and promote epithelial-mesenchymal transition via p-FAK/p-paxillin/YAP signaling.
Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing.
TNFSF14/LIGHT promotes cardiac fibrosis and atrial fibrillation vulnerability via PI3Kγ/SGK1 pathway-dependent M2 macrophage polarisation.
METTL14 reverses liver fibrosis by inhibiting NOVA2 through an m6A-YTHDF2-dependent mechanism.
Effect of roflumilast on airway remodeling in asthmatic mice exposed to or not exposed to cigarette smoke: Comparison with the effect of dexamethasone.
MicroRNA-146a Promotes Embryonic Stem Cell Differentiation towards Vascular Smooth Muscle Cells through Regulation of Kruppel-like Factor 4.
Myocardin Reverses Hypoxia-Inducible Factor-1α Mediated Phenotypic Modulation of Corpus Cavernosum Smooth Muscle Cells in Hypoxia Induced by Cobalt Chloride.
Restoration of Sinusoid Fenestrae Followed by Targeted Nanoassembly Delivery of an Anti-Fibrotic Agent Improves Treatment Efficacy in Liver Fibrosis.
Biomimetic nanoparticles drive the mechanism understanding of shear-wave elasticity stiffness in triple negative breast cancers to predict clinical treatment.
Breach of tolerance versus burden of bile acids: Resolving the conundrum in the immunopathogenesis and natural history of primary biliary cholangitis.
A novel co-culture assay to evaluate the effects of sympathetic innervation on vascular smooth muscle differentiation.
Fate mapping RNA-sequencing reveal Malat1 regulates Sca1(+) progenitor cells to vascular smooth muscle cells transition in vascular remodeling.
Active ingredients screening and pharmacological mechanism research of curcumae rhizoma-sparganii rhizoma herb pair ameliorates liver fibrosis based on network pharmacology.
SCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice.
Fasudil alleviates the vascular endothelial dysfunction and several phenotypes of Fabry disease.
Continuous Monochromatic Blue Light Exacerbates High-Fat Diet-Induced Kidney Injury via Corticosterone-Mediated Oxidative Stress.
Activation of NRF2 Signaling Pathway Delays the Progression of Hyperuricemic Nephropathy by Reducing Oxidative Stress.
Establishment of a Rat Model of Liver Venous Deprivation: Simultaneous Portal and Hepatic Vein Ligation.
Two-Pore-Domain Potassium Channel TREK-1 Mediates Pulmonary Fibrosis through Macrophage M2 Polarization and by Direct Promotion of Fibroblast Differentiation.
Jia-Wei-Si-Miao-Yong-An Fang stimulates the healing of acute radiation-induced cutaneous wounds through MAPK/ERK pathway.
Synergistic effect of constituent drugs of Baibutang on improving Yin-deficiency pulmonary fibrosis in rats.
Progerinin, an Inhibitor of Progerin, Alleviates Cardiac Abnormalities in a Model Mouse of Hutchinson-Gilford Progeria Syndrome.
Histone lactylation driven by mROS-mediated glycolytic shift promotes hypoxic pulmonary hypertension.
Brevilin A is a potent anti-metastatic CRC agent that targets the VEGF-IL6-STAT3 axis in the HSCs-CRC interplay.
GL-V9 ameliorates liver fibrosis by inhibiting TGF-β/smad pathway.
Selective Inhibition of Histone Deacetylase Class IIa With MC1568 Ameliorates Podocyte Injury.
Deciphering Key Foreign Body Reaction-Related Transcription Factors and Genes Through Transcriptome Analysis.
Establishment of a New Abdominal Aortic Aneurysm Model in Rats by a Retroperitoneal Approach.
Anti-fibrotic effect of extracellular vesicles derived from tea leaves in hepatic stellate cells and liver fibrosis mice.
Hepatoblastoma: Derived Exosomal LncRNA NEAT1 Induces BMSCs Differentiation into Tumor-Supporting Myofibroblasts via Modulating the miR-132/MMP9 Axis.
C/EBPα-Mediated Transcriptional Activation of PIK3C2A Regulates Autophagy, Matrix Metalloproteinase Expression, and Phenotypic of Vascular Smooth Muscle Cells in Aortic Dissection.
Targeting Ferroptosis Attenuates Inflammation, Fibrosis, and Mast Cell Activation in Chronic Prostatitis.
Blocking REDD1/TXNIP Complex Ameliorates HG-Induced Renal Tubular Epithelial Cell Apoptosis and EMT through Repressing Oxidative Stress.
The Traditional Chinese Medicine Formula FTZ Protects against Cardiac Fibrosis by Suppressing the TGFβ1-Smad2/3 Pathway.
Hsa_circRNA_0008028 Deficiency Ameliorates High Glucose-Induced Proliferation, Calcification, and Autophagy of Vascular Smooth Muscle Cells via miR-182-5p/TRIB3 Axis.
p16(INK4a) Plays Critical Role in Exacerbating Inflammaging in High Fat Diet Induced Skin.
HBO1 as an Important Target for the Treatment of CCL4-Induced Liver Fibrosis and Aged-Related Liver Aging and Fibrosis.
Qufeng Xuanbi Formula Ameliorates Airway Remodeling in Asthmatic Mice by Suppressing Airway Smooth Muscle Cell Proliferation through MEK/ERK Signaling Pathway.
Tissue Kallikrein Protects Rat Prostate against the Inflammatory Damage in a Chronic Autoimmune Prostatitis Model via Restoring Endothelial Function in a Bradykinin Receptor B2-Dependent Way.
Blockade of SK4 channels suppresses atrial fibrillation by attenuating atrial fibrosis in canines with prolonged atrial pacing.
Commensal microbe-derived SCFA alleviates atrial fibrillation via GPR43/NLRP3 signaling.
Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/β-catenin pathway.
The conditioned medium from mesenchymal stromal cells pretreated with proinflammatory cytokines promote fibroblasts migration and activation.
Exosome Derived from Mesenchymal Stem Cells Alleviates Pathological Scars by Inhibiting the Proliferation, Migration and Protein Expression of Fibroblasts via Delivering miR-138-5p to Target SIRT1.
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
Regenerative Peripheral Nerve Interfaces Effectively Prevent Neuroma Formation After Sciatic Nerve Transection in Rats.
Metformin Ameliorates Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells in Diabetes by Increasing Vitamin D Receptor Expression.
Macrophage SCAP Contributes to Metaflammation and Lean NAFLD by Activating STING-NF-κB Signaling Pathway.
Heidihuangwan alleviates renal fibrosis in rats with 5/6 nephrectomy by inhibiting autophagy.
Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling.
Inhibition of calpain9 attenuates peritoneal dialysis-related peritoneal fibrosis.
TIM-4 in macrophages contributes to nasal polyp formation through the TGF-β1-mediated epithelial to mesenchymal transition in nasal epithelial cells.
Inhibition of HDAC6 With CAY10603 Ameliorates Diabetic Kidney Disease by Suppressing NLRP3 Inflammasome.
Ganfule capsule alleviates bile duct ligation-induced liver fibrosis in mice by inhibiting glutamine metabolism.
Akkermansia muciniphila Alters Gut Microbiota and Immune System to Improve Cardiovascular Diseases in Murine Model.
Beneficial Effect of Edoxaban on Preventing Atrial Fibrillation and Coagulation by Reducing Inflammation via HBG1/HBD Biomarkers.
Mechanism of Endoplasmic Reticulum Stress Pathway in the Osteogenic Phenotypic Transformation of Aortic Valve Interstitial Cells.
Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3/p-STAT3/GLUT1 Signaling Pathway.
Atorvastatin Restores PPARα Inhibition of Lipid Metabolism Disorders by Downregulating miR-21 Expression to Improve Mitochondrial Function and Alleviate Diabetic Nephropathy Progression.
Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps.
Tormentic Acid Ameliorates Hepatic Fibrosis in vivo by Inhibiting Glycerophospholipids Metabolism and PI3K/Akt/mTOR and NF-κB Pathways: Based on Transcriptomics and Metabolomics.
Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 in Extracellular Vesicles Promotes Hepatic Stellate Cell Activation, Liver Fibrosis and β-Catenin Signaling Pathway.
Loss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis.
Yao medicine Amydrium hainanense suppresses hepatic fibrosis by repressing hepatic stellate cell activation via STAT3 signaling.
Endothelial S1pr2 regulates post-ischemic angiogenesis via AKT/eNOS signaling pathway.
Norepinephrine acting on adventitial fibroblasts stimulates vascular smooth muscle cell proliferation via promoting small extracellular vesicle release.
Irradiation enhances the malignancy-promoting behaviors of cancer-associated fibroblasts.
Fibroblasts mediate the angiogenesis of pheochromocytoma by increasing COX4I2 expression.
Resveratrol ameliorates iron overload induced liver fibrosis in mice by regulating iron homeostasis.
Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway.
From hair to liver: emerging application of hair follicle mesenchymal stem cell transplantation reverses liver cirrhosis by blocking the TGF-β/Smad signaling pathway to inhibit pathological HSC activation.
Injectable selenium-containing polymeric hydrogel formulation for effective treatment of myocardial infarction.
Lycorine Inhibits Hypertrophic Scar Formation by Inducing ROS-Mediated Apoptosis.
Asiaticoside Combined With Carbon Ion Implantation to Improve the Biocompatibility of Silicone Rubber and to Reduce the Risk of Capsule Contracture.
Macrophage derived miR-7219-3p-containing exosomes mediate fibroblast trans-differentiation by targeting SPRY1 in silicosis.
Fatty acid-binding protein 5 aggravates pulmonary artery fibrosis in pulmonary hypertension secondary to left heart disease via activating wnt/β-catenin pathway.
Anti-angiogenic nano-delivery system promotes tumor vascular normalizing and micro-environment reprogramming in solid tumor.
Substitution of SERCA2 Cys(674) accelerates aortic aneurysm by inducing endoplasmic reticulum stress and promoting cell apoptosis.
Hydroxyurea protects against diabetic cardiomyopathy by inhibiting inflammation and apoptosis.
N-Acetyl-l-tryptophan inhibits CCl(4)-induced hepatic fibrogenesis via regulating TGF-β1/SMAD and Hippo/YAP1 signal.
Immunohistochemical analysis of PD-L1 and tumor-infiltrating immune cells expression in the tumor microenvironment of primary signet ring cell carcinoma of the prostate.
Metabonomics profile analysis in inflammation-induced preterm birth and the potential role of metabolites in regulating premature cervical ripening.
Alamandine alleviated heart failure and fibrosis in myocardial infarction mice.
A dual Keap1 and p47(phox) inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis.
miR-182-5p attenuates Schistosoma japonicum-induced hepatic fibrosis by targeting tristetraprolin.
Leucine Supplementation in Middle-Aged Male Mice Improved Aging-Induced Vascular Remodeling and Dysfunction via Activating the Sirt1-Foxo1 Axis.
Cyclodextrin boostered-high density lipoprotein for antiatherosclerosis by regulating cholesterol efflux and efferocytosis.
Studies of ultrastructure, gene expression, and marker analysis reveal that mouse bladder PDGFRA(+) interstitial cells are fibroblasts.
Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production.
Salt-inducible kinase 1 deficiency promotes vascular remodeling in pulmonary arterial hypertension via enhancement of yes-associated protein-mediated proliferation.
Anti-inflammatory potential of stevia residue extract against uric acid-associated renal injury in mice.
Activating α7nAChR ameliorates abdominal aortic aneurysm through inhibiting pyroptosis mediated by NLRP3 inflammasome.
UFMylation Is Activated in Atherosclerosis of ApoE Knockout Mice.
Substitution of the SERCA2 Cys(674) reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation.
Induction of GLI1 by miR-27b-3p/FBXW7/KLF5 pathway contributes to pulmonary arterial hypertension.
Established new compound IMB16-4 self-emulsifying drug delivery systems for increasing oral bioavailability and enhancing anti-hepatic fibrosis effect.
CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment.
A network pharmacology-based study on the mechanism of astragaloside IV alleviating renal fibrosis through the AKT1/GSK-3β pathway.
Vascular restenosis reduction with platelet membrane coated nanoparticle directed M2 macrophage polarization.
Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and ameliorates organ fibrosis.
Single-cell RNA-seq analysis of testicular somatic cell development in pigs.
Cancer-associated fibroblast-secreted miR-421 promotes pancreatic cancer by regulating the SIRT3/H3K9Ac/HIF-1α axis.
Biomimetic cell membrane-coated glucose/oxygen-exhausting nanoreactor for remodeling tumor microenvironment in targeted hypoxic tumor therapy.
Apigenin inhibits fibrous scar formation after acute spinal cord injury through TGFβ/SMADs signaling pathway.
Apatinib Through Activating the RhoA/ROCK Signaling Pathway to Cause Dysfunction of Vascular Smooth Muscle Cells.
Extracellular vesicles from human urine-derived stem cells merged in hyaluronic acid ameliorate erectile dysfunction in type 2 diabetic rats by glans administration.
Aligned nanofibrous collagen membranes from fish swim bladder as a tough and acid-resistant suture for pH-regulated stomach perforation and tendon rupture.
Pirfenidone-loaded exosomes derived from pancreatic ductal adenocarcinoma cells alleviate fibrosis of premetastatic niches to inhibit liver metastasis.
The Impact of Sleep Disturbance on Gut Microbiota, Atrial Substrate, and Atrial Fibrillation Inducibility in Mice: A Multi-Omics Analysis.
Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis.
A Shape-Adaptive Gallic Acid Driven Multifunctional Adhesive Hydrogel Loaded with Scolopin2 for Wound Repair.
Ultrastructural Characterization of Human Gingival Fibroblasts in 3D Culture.
LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis.
Targeting glutamine metabolism in hepatic stellate cells alleviates liver fibrosis.
S100A8-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Macrophages Facilitates Liver Fibrosis Progression.
Disulfiram ameliorates nonalcoholic steatohepatitis by modulating the gut microbiota and bile acid metabolism.
NLRC3 deficiency promotes cutaneous wound healing due to the inhibition of p53 signaling.
PEDF reduces malignant cells proliferation and inhibits the progression of myelofibrosis in myeloproliferative neoplasms.
Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells.
Cancer associated fibroblast-derived CCL5 promotes hepatocellular carcinoma metastasis through activating HIF1α/ZEB1 axis.
Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway.
Development and identification of a induced pluripotent stem cells line (SMBCi013-A) derived from urine cells of a patient with Wilson's disease.
Kinsenoside attenuates liver fibro-inflammation by suppressing dendritic cells via the PI3K-AKT-FoxO1 pathway.
MicroRNA-130a attenuates cardiac fibrosis after myocardial infarction through TGF-β/Smad signaling by directly targeting TGF-β receptor 1.
P16ink4a overexpression ameliorates cardiac remodeling of mouse following myocardial infarction via CDK4/pRb pathway.
The SETD8/ELK1/bach1 complex regulates hyperglycaemia-mediated EndMT in diabetic nephropathy.
Ferroptosis, a new target for treatment of renal injury and fibrosis in a 5/6 nephrectomy-induced CKD rat model.
Exosomal let-7i-5p from three-dimensional cultured human umbilical cord mesenchymal stem cells inhibits fibroblast activation in silicosis through targeting TGFBR1.
Knockdown of long noncoding RNA MIAT attenuates cigarette smoke-induced airway remodeling by downregulating miR-29c-3p-HIF3A axis.
Citri Reticulatae Pericarpium alleviates postmyocardial infarction heart failure by upregulating PPARγ expression.
Modification of lysine deacetylation regulates curcumol-induced necroptosis through autophagy in hepatic stellate cells.
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
Gli(ko) BMSC: A potential strategy of treatment for renal fibrosis.
Myelin-associated glycoprotein combined with chitin conduit inhibits painful neuroma formation after sciatic nerve transection.
Tracking the response to Pseudomonas aeruginosa infection in ozone-induced chronic obstructive pulmonary disease mouse models.
Molecular feature of arterial remodeling in the brain arteriovenous malformation revealed by arteriovenous shunt rat model and RNA sequencing.
Targeted inhibition of the immunoproteasome blocks endothelial MHC class II antigen presentation to CD4(+) T cells in chronic liver injury.
Capsaicin ameliorates renal fibrosis by inhibiting TGF-β1-Smad2/3 signaling.
Hydroxychloroquine alleviates renal interstitial fibrosis by inhibiting the PI3K/Akt signaling pathway.
Erectile dysfunction in hypospadiac male adult rats induced by maternal exposure to di-n-butyl phthalate.
CUX1 promotes epithelial-mesenchymal transition (EMT) in renal fibrosis of UUO model by targeting MMP7.
Spermidine Ameliorates Nonalcoholic Steatohepatitis through Thyroid Hormone-Responsive Protein Signaling and the Gut Microbiota-Mediated Metabolism of Bile Acids.
Generation of a non-integrated induced pluripotent stem cell line from urine cells of a Chinese osteogenesis imperfecta type I patient.
Generation of induced pluripotent stem cells named SMBCi019-A from a methylmalonic acidemia patient carrying the MMACHC mutations.
Establishment of a control induced pluripotent stem cell line SMBCi018-A from a patient with congenital talipes equinovarus.
LncRNA LINC00961 regulates endothelial‑mesenchymal transition via the PTEN‑PI3K‑AKT pathway.
Asperuloside inhibited epithelial-mesenchymal transition in colitis associated cancer via activation of vitamin D receptor.
Peptidome analysis of human intrauterine adhesion tissues and the identification of antifibrotic peptide.
Albumin-induced premature senescence in human renal proximal tubular cells and its relationship with intercellular fibrosis.
Nintedanib Inhibits Endothelial Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis via Focal Adhesion Kinase Activity Reduction.
Interplay of Helicobacter pylori, fibroblasts, and cancer cells induces fibroblast activation and serpin E1 expression by cancer cells to promote gastric tumorigenesis.
Identification of the active compounds and functional mechanisms of Jinshui Huanxian formula in pulmonary fibrosis by integrating serum pharmacochemistry with network pharmacology.
Bmp7 drives proximal tubule expansion and determines nephron number in the developing kidney.
BMSC-derived exosomes protect against kidney injury through regulating klotho in 5/6 nephrectomy rats.
Monochromatic blue light not green light exposure is associated with continuous light-induced hepatic steatosis in high fat diet fed-mice via oxidative stress.
The DR1‑CSE/H(2)S system inhibits renal fibrosis by downregulating the ERK1/2 signaling pathway in diabetic mice.
Histone methyltransferase DOT1L mediates the TGF-β1/Smad3 signaling pathway through epigenetic modification of SYK in myocardial infarction.
Jolkinolide B alleviates renal fibrosis via anti-inflammation and inhibition of epithelial-mesenchymal transition in unilateral ureteral obstruction mice.
Isolation and characterization of secondary metabolites from the leaves of Sauropus spatulifolius Beille and their potential biological assays.
Endothelial cell metabolic memory causes cardiovascular dysfunction in diabetes.
N6-Methyladenosine Modification of CDH1 mRNA Promotes PM2.5-Induced Pulmonary Fibrosis via Mediating Epithelial Mesenchymal Transition.
ZC3H4 promotes pulmonary fibrosis via an ER stress-related positive feedback loop.
New IMB16-4 Nanoparticles Improved Oral Bioavailability and Enhanced Anti-Hepatic Fibrosis on Rats.
Uncaria Rhynchophylla attenuates angiotensin Ⅱ-induced myocardial fibrosis via suppression of the RhoA/ROCK1 pathway.
One-Step Synthesis of Multifunctional Chitosan Hydrogel for Full-Thickness Wound Closure and Healing.
Remodeling Chondroitin-6-Sulfate-Mediated Immune Exclusion Enhances Anti-PD-1 Response in Colorectal Cancer with Microsatellite Stability.
TiO(2) nanosheets promote the transformation of vascular smooth muscle cells into foam cells in vitro and in vivo through the up-regulation of nuclear factor kappa B subunit 2.
Necroptosis in pulmonary macrophages promotes silica-induced inflammation and interstitial fibrosis in mice.
IL13 and periostin in active fibrogenic areas of the extrahepatic bile ducts in biliary atresia patients.
A comprehensive analysis on the relationship between BDE-209 exposure and erectile dysfunction.
Branched-chain amino acid transaminase 1 inhibition attenuates childhood asthma in mice by effecting airway remodeling and autophagy.
Poly I:C Exacerbates Airway Inflammation and Remodeling in Cigarette Smoke-Exposed Mice.
Multifunctional Silk Fibroin Methacryloyl Microneedle for Diabetic Wound Healing.
Deletion of SIRT6 in vascular smooth muscle cells facilitates vascular calcification via suppression of DNA damage repair.
IL-8 exacerbates CCl(4)-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway.
PVT1/miR-145-5p/HK2 modulates vascular smooth muscle cells phenotype switch via glycolysis: The new perspective on the spiral artery remodeling.
Inhibition of glutamine transporter ASCT2 mitigates bleomycin-induced pulmonary fibrosis in mice.
Bempedoic acid, an ATP citrate lyase inhibitor, reduces intimal hyperplasia via activation of AMPKα signaling pathway.
A multifunctional black phosphorus-based adhesive patch intrinsically induces partial EMT for effective burn wound healing.
The Influence of Novel, Biocompatible, and Bioresorbable Poly(3-hydroxyoctanoate) Dressings on Wound Healing in Mice.
Overexpressed DDX3x promotes abdominal aortic aneurysm formation and activates AKT in ApoE knockout mice.
Insights into the mechanism underlying crystalline silica-induced pulmonary fibrosis via transcriptome-wide m(6)A methylation profile.
Development of a human iPSC line (SMBCi017-A) from a healthy donor.
Use of wogonin as a cooperative drug with praziquantel to better combat schistosomiasis.
Long noncoding RNA GAS5 inhibits LX-2 cells activation by suppressing NF-κB signalling through regulation of the miR-433-3p/TLR10 axis.
Riboflavin deficiency leads to irreversible cellular changes in the RPE and disrupts retinal function through alterations in cellular metabolic homeostasis.
Corn oligopeptides inhibit Akt/NF-κB signaling pathway and inflammatory factors to ameliorate CCl(4) -induced hepatic fibrosis in mice.
Construction and identification of an immortalized rat intestinal smooth muscle cell line.
Curcumin attenuates vascular calcification via the exosomal miR-92b-3p/KLF4 axis.
FXR deficiency in hepatocytes disrupts the bile acid homeostasis and inhibits autophagy to promote liver injury in Schistosoma japonicum-infected mice.
LncRNA SNHG11 promotes the malignant transformation of human bronchial epithelial cells induced by beryllium sulfate.
Morroniside, a novel GATA3 binding molecule, inhibits hepatic stellate cells activation by enhancing lysosomal acid lipase expression.
Circ_0047339 promotes the activation of fibroblasts and affects the development of urethral stricture by targeting the miR-4691-5p/TSP-1 axis.
Integrated single-cell transcriptomics and proteomics reveal cellular-specific responses and microenvironment remodeling in aristolochic acid nephropathy.
Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy.
ZC3H4 regulates infiltrating monocytes, attenuating pulmonary fibrosis through IL-10.
Antifibrotic and anthelminthic effect of casticin on Schistosoma mansoni-infected BALB/c mice.
Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B.
Botox-A improve the thyroid-associated ophthalmopathy (TAO) orbital fibroblast activation through inhibiting the TGF-β/Smad signaling.
Pharmacological targeting macrophage phenotype via gut-kidney axis ameliorates renal fibrosis in mice.
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways.
HPV(+) HNSCC-derived exosomal miR-9-5p inhibits TGF-β signaling-mediated fibroblast phenotypic transformation through NOX4.
Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice.
Mechanosensitive Piezo1 channels mediate renal fibrosis.
PEDF is an antifibrosis factor that inhibits the activation of fibroblasts in a bleomycin-induced pulmonary fibrosis rat model.
TRPM2 Promotes Atherosclerotic Progression in a Mouse Model of Atherosclerosis.
MED12 Regulates Smooth Muscle Cell Functions and Participates in the Development of Aortic Dissection.
BRCC36 prevents vascular calcification in chronic kidney disease through the β-catenin signalling pathway.
Effect of Microgroove Structure in PDMS-Based Silicone Implants on Biocompatibility.
Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice.
Aberrantly Expressed Galectin-9 Is Involved in the Immunopathogenesis of Anti-MDA5-Positive Dermatomyositis-Associated Interstitial Lung Disease.
JMJD1A/NR4A1 Signaling Regulates the Procession of Renal Tubular Epithelial Interstitial Fibrosis Induced by AGEs in HK-2.
STAT3 and IL-6 Contribute to Corticosteroid Resistance in an OVA and Ozone-induced Asthma Model with Neutrophil Infiltration.
Circulating Soluble Suppression of Tumorigenicity 2 Predicts Recurrence After Radiofrequency Ablation of Persistent Atrial Fibrillation.
Exosomes Containing LINC00636 Inhibit MAPK1 through the miR-450a-2-3p Overexpression in Human Pericardial Fluid and Improve Cardiac Fibrosis in Patients with Atrial Fibrillation.
Nobiletin Attenuates Pathological Cardiac Remodeling after Myocardial Infarction via Activating PPARγ and PGC1α.
Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates.
Sodium Houttuyfonate Ameliorates β-amyloid(1-42)-Induced Memory Impairment and Neuroinflammation through Inhibiting the NLRP3/GSDMD Pathway in Alzheimer's Disease.
Network Pharmacology-Based Mechanistic Investigation of Jinshui Huanxian Formula Acting on Idiopathic Pulmonary Fibrosis.
PP2 Ameliorates Renal Fibrosis by Regulating the NF-κB/COX-2 and PPARγ/UCP2 Pathway in Diabetic Mice.
Ginkgo Biloba Extract EGB761 Ameliorates the Extracellular Matrix Accumulation and Mesenchymal Transformation of Renal Tubules in Diabetic Kidney Disease by Inhibiting Endoplasmic Reticulum Stress.
Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice.
Puerarin Alleviates UUO-Induced Inflammation and Fibrosis by Regulating the NF-κB P65/STAT3 and TGFβ1/Smads Signaling Pathways.
Wogonin Alleviates Kidney Tubular Epithelial Injury in Diabetic Nephropathy by Inhibiting PI3K/Akt/NF-κB Signaling Pathways.
Fasudil Dichloroacetate Alleviates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension by Ameliorating Dysfunction of Pulmonary Arterial Smooth Muscle Cells.
Overexpression of TC2N is associated with poor prognosis in gastric cancer.
Tongluo Yishen Decoction Ameliorates Renal Fibrosis via Regulating Mitochondrial Dysfunction Induced by Oxidative Stress in Unilateral Ureteral Obstruction Rats.
β2-Adrenergic Receptor Enhances the Alternatively Activated Macrophages and Promotes Biliary Injuries Caused by Helminth Infection.
Identification of a Novel Gene Correlated With Vascular Smooth Muscle Cells Proliferation and Migration in Chronic Thromboembolic Pulmonary Hypertension.
Transcriptome-Based Network Analysis Reveals Hirudin Potentiates Anti-Renal Fibrosis Efficacy in UUO Rats.
Icariin Ameliorates Diabetic Renal Tubulointerstitial Fibrosis by Restoring Autophagy via Regulation of the miR-192-5p/GLP-1R Pathway.
Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis Partly by Inhibiting the Expression of LOX and LOXL-2.
Comprehensive Bioinformatics Analysis Identifies POLR2I as a Key Gene in the Pathogenesis of Hypertensive Nephropathy.
Exploration of the Modulatory Property Mechanism of ELeng Capsule in the Treatment of Endometriosis Using Transcriptomics Combined With Systems Network Pharmacology.
ShenLian Extract Enhances TGF-β Functions in the Macrophage-SMC Unit and Stabilizes Atherosclerotic Plaques.
Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.
iTRAQ-Based Proteomics Reveals Gu-Ben-Fang-Xiao Decoction Alleviates Airway Remodeling via Reducing Extracellular Matrix Deposition in a Murine Model of Chronic Remission Asthma.
Exogenous H(2) S prevents the nuclear translocation of PDC-E1 and inhibits vascular smooth muscle cell proliferation in the diabetic state.
Interferon-induced protein 16 expression in colorectal cancer and its correlation with proliferation and immune signature markers.
Presegetane diterpenoids from Euphorbia sieboldiana as a new type of anti-liver fibrosis agents that inhibit TGF-β/Smad signaling pathway.
Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus.
MiR-200c-3p promotes ox-LDL-induced endothelial to mesenchymal transition in human umbilical vein endothelial cells through SMAD7/YAP pathway.
Effect of different exercise training intensities on age-related cardiac damage in male mice.
The promoting role of Cx43 on the proliferation and migration of arterial smooth muscle cells for angiotensin II-dependent hypertension.
Heat-killed Propionibacterium acnes augment the protective effect of 28-kDa glutathione S-transferases antigen against Schistosoma mansoni infection.
Potential Vasculoprotective Effects of Blackcurrant (Ribes nigrum) Extract in Diabetic KK-A(y) Mice.
Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer.
METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner.
Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway.
Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling.
Low-intensity pulsed ultrasound prevents prolonged hypoxia-induced cardiac fibrosis through HIF-1α/DNMT3a pathway via a TRAAK-dependent manner.
Inhibition of MAD2B alleviates venous neointimal formation by suppressing VSMCs proliferation and migration.
Dysregulations of miR-503-5p and Wnt/β-catenin pathway coordinate in mediating cadmium-induced kidney fibrosis.
Blood glucose control contributes to protein stability of Ski-related novel protein N in a rat model of diabetes.
Maiwei Yangfei decoction prevents bleomycin-induced pulmonary fibrosis in mice.
Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension.
MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.
SAA1 is transcriptionally activated by STAT3 and accelerates renal interstitial fibrosis by inducing endoplasmic reticulum stress.
ZC3H4 mediates silica-induced EndoMT via ER stress and autophagy.
Establishment of an iPSC line (CSUXHi004-A) from a patient with Waardenburg syndrome type I caused by a PAX3 splice mutation.
Macrophage-derived exosomes mediate silica-induced pulmonary fibrosis by activating fibroblast in an endoplasmic reticulum stress-dependent manner.
MiR-155 promotes colitis-associated intestinal fibrosis by targeting HBP1/Wnt/β-catenin signalling pathway.
Splicing factor SRSF6 mediates pleural fibrosis.
Controlled release of KGF-2 for regulation of wound healing by KGF-2 complexed with "lotus seedpod surface-like" porous microspheres.
Glucagon-like peptide-1 (GLP-1) improved diabetic lung fibrosis via AMPK and microRNA-27a (miR-27a).
KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury.
Scoparone alleviates Ang II-induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress.
A selective small-molecule inhibitor of c-Met suppresses keloid fibroblast growth in vitro and in a mouse model.
Amyloid pathology arrangements in Alzheimer's disease brains modulate in vivo seeding capability.
Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway.
Study on the effect of Mongolian medicine Qiwei Qinggan Powder on hepatic fibrosis through JAK2/STAT3 pathway.
Anti-Fibrosis Effects of Magnesium Lithospermate B in Experimental Pulmonary Fibrosis: By Inhibiting TGF-βRI/Smad Signaling.
The MIR155 host gene/microRNA-627/HMGB1/NF-κB loop modulates fibroblast proliferation and extracellular matrix deposition.
Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis.
Circular RNA UVRAG Mediated by Alternative Splicing Factor NOVA1 Regulates Adhesion and Migration of Vascular Smooth Muscle Cells.
Photobiomodulation therapy promotes the ATP-binding cassette transporter A1-dependent cholesterol efflux in macrophage to ameliorate atherosclerosis.
Fructose-1,6-bisphosphatase aggravates oxidative stress-induced apoptosis in asthma by suppressing the Nrf2 pathway.
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.
Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice.
Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway.
Interleukin-6 participates in human pancreatic stellate cell activation and collagen I production via TGF-β1/Smad pathway.
C188-9 reduces TGF-β1-induced fibroblast activation and alleviates ISO-induced cardiac fibrosis in mice.
ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy.
Dopamine D1 receptor alleviates doxorubicin-induced cardiac injury by inhibiting NLRP3 inflammasome.
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability.
Mesenchymal stem cells ameliorate renal fibrosis by galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat.
Type 2 Alveolar Epithelial Cells Differentiated from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Mouse Pulmonary Fibrosis Through β-Catenin-Regulated Cell Apoptosis.
Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression.
Amygdalin inhibits TGFβ1-induced activation of hepatic stellate cells (HSCs) in vitro and CCl(4)-induced hepatic fibrosis in rats in vivo.
Effect of human umbilical cord-derived mesenchymal stem cells on murine model of bronchiolitis obliterans like injury.
Tormentic acid inhibits hepatic stellate cells activation via blocking PI3K/Akt/mTOR and NF-κB signalling pathways.
Selective eradication of pluripotent stem cells by inhibiting DHODH activity.
Endogenous hydrogen sulfide improves vascular remodeling through PPARδ/SOCS3 signaling.
Comparative cytotoxicity studies of halophenolic disinfection byproducts using human extended pluripotent stem cells.
Hypoxia-induced FOXO4/LDHA axis modulates gastric cancer cell glycolysis and progression.
Indoleamine 2,3-dioxygenase 1 limits hepatic inflammatory cells recruitment and promotes bile duct ligation-induced liver fibrosis.
Identification of key pathways and hub genes in the myogenic differentiation of pluripotent stem cell: a bioinformatics and experimental study.
MiR-30c-5p regulates adventitial progenitor cells differentiation to vascular smooth muscle cells through targeting OPG.
The zonula occludens protein family regulates the hepatic barrier system in the murine liver.
Up-regulation of FUT8 inhibits TGF-β1-induced activation of hepatic stellate cells during liver fibrogenesis.
FoxM1 promotes Wnt/β-catenin pathway activation and renal fibrosis via transcriptionally regulating multi-Wnts expressions.
Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress.
Keratin 1 attenuates hypoxic pulmonary artery hypertension by suppressing pulmonary artery media smooth muscle expansion.
BML-111, the lipoxin A4 agonist, modulates VEGF or CoCl2-induced migration, angiogenesis and permeability in tumor-derived endothelial cells.
Fe(3)O(4) magnetic nanoparticles ameliorate albumin-induced tubulointerstitial fibrosis by autophagy related to Rab7.
Osteogenic differentiation and calcification of human aortic smooth muscle cells is induced by the RCN2/STAT3/miR-155-5p feedback loop.
Preparation of a recombinant collagen-peptide (RHC)-conjugated chitosan thermosensitive hydrogel for wound healing.
Ursodesoxycholic acid alleviates liver fibrosis via proregeneration by activation of the ID1-WNT2/HGF signaling pathway.
miR-184 targets TP63 to block idiopathic pulmonary fibrosis by inhibiting proliferation and epithelial-mesenchymal transition of airway epithelial cells.
Blackcurrant (Ribes nigrum L.) Extract Exerts Potential Vasculoprotective Effects in Ovariectomized Rats, Including Prevention of Elastin Degradation and Pathological Vascular Remodeling.
Homocysteine promotes cardiac fibrosis by regulating the Akt/FoxO3 pathway.
NAMPT-mediated NAD(+) biosynthesis suppresses activation of hepatic stellate cells and protects against CCl(4)-induced liver fibrosis in mice.
Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial-mesenchymal plasticity of human peritoneal mesothelial cells.
Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.
Vasoactive intestinal peptide attenuates bleomycin-induced murine pulmonary fibrosis by inhibiting epithelial-mesenchymal transition: Restoring autophagy in alveolar epithelial cells.
MicroRNA-210-5p alleviates cardiac fibrosis via targeting transforming growth factor-beta type I receptor in rats on high sodium chloride (NaCl)-based diet.
Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis.
Inhibition of microRNA-30a alleviates vascular remodeling in pulmonary arterial hypertension.
Pterostilbene Ameliorates Renal Damage in Diabetic Rats by Suppressing Hyperglycemia with Inhibition of Inflammatory and Fibrotic Responses.
Effects of L-leucine on the properties of spray-dried swellable microparticles with wrinkled surfaces for inhalation therapy of pulmonary fibrosis.
A suitable silicosis mouse model was constructed by repeated inhalation of silica dust via nose.
Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation.
RNO3 QTL regulates vascular structure and arterial stiffness in the spontaneously hypertensive rat.
Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization.
BGP-15 Inhibits Hyperglycemia-Aggravated VSMC Calcification Induced by High Phosphate.
PDGF-BB/SA/Dex injectable hydrogels accelerate BMSC-mediated functional full thickness skin wound repair by promoting angiogenesis.
Generation of an EFNB2-2A-mCherry reporter human embryonic stem cell line using CRISPR/Cas9-mediated site-specific homologous recombination.
mRNA Transcriptome Analysis of Bone in a Mouse Model of Implant-Associated Staphylococcus aureus Osteomyelitis.
Inhibiting SLC26A4 reverses cardiac hypertrophy in H9C2 cells and in rats.
The Effect of Resveratrol and Quercetin on Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem Cell.
Glutamate-Cysteine Ligase Catalytic Subunit Attenuated Hepatitis C Virus-Related Liver Fibrosis and Suppressed Endoplasmic Reticulum Stress.
Sodium Tanshinone IIA Sulfonate Attenuates Erectile Dysfunction in Rats with Hyperlipidemia.
Bergenin Attenuates Hepatic Fibrosis by Regulating Autophagy Mediated by the PPAR-γ/TGF-β Pathway.
Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner.
Biological and Proteomic Characteristics of an Immortalized Human Pancreatic Stellate Cell Line.
Septin4 Prevents PDGF-BB-induced HAVSMC Phenotypic Transformation, Proliferation and Migration by Promoting SIRT1-STAT3 Deacetylation and Dephosphorylation.
The role of Stim1 in the progression of lupus nephritis in mice.
Inactivation of Pancreatic Stellate Cells by Exendin-4 Inhibits the Migration and Invasion of Pancreatic Cancer Cells.
High-Intensity Interval Training Attenuates Ketogenic Diet-Induced Liver Fibrosis in Type 2 Diabetic Mice by Ameliorating TGF-β1/Smad Signaling.
Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha.
Notch3 Modulates Cardiac Fibroblast Proliferation, Apoptosis, and Fibroblast to Myofibroblast Transition via Negative Regulation of the RhoA/ROCK/Hif1α Axis.
Integrating Network Pharmacology and Experimental Validation to Investigate the Effects and Mechanism of Astragalus Flavonoids Against Hepatic Fibrosis.
Fisetin Alleviated Bleomycin-Induced Pulmonary Fibrosis Partly by Rescuing Alveolar Epithelial Cells From Senescence.
Hyperoside Attenuates Bleomycin-Induced Pulmonary Fibrosis Development in Mice.
Fibroblast Growth Factor 1 Ameliorates Diabetes-Induced Liver Injury by Reducing Cellular Stress and Restoring Autophagy.
Scutellarein inhibits BLM-mediated pulmonary fibrosis by affecting fibroblast differentiation, proliferation, and apoptosis.
GADD45B Promotes Glucose-Induced Renal Tubular Epithelial-Mesenchymal Transition and Apoptosis via the p38 MAPK and JNK Signaling Pathways.
Salvia miltiorrhiza-derived miRNAs suppress vascular remodeling through regulating OTUD7B/KLF4/NMHC IIA axis.
Aerosolized Thyroid Hormone Prevents Radiation Induced Lung Fibrosis.
The F-box protein FBXO11 restrains hepatocellular carcinoma stemness via promotion of ubiquitin-mediated degradation of Snail.
Abnormal expression of homeobox c6 in the atherosclerotic aorta and its effect on proliferation and migration of rat vascular smooth muscle cells.
Inhibition of p66Shc Oxidative Signaling via CA-Induced Upregulation of miR-203a-3p Alleviates Liver Fibrosis Progression.
Porphyromonas gingivalis disrupts vascular endothelial homeostasis in a TLR-NF-κB axis dependent manner.
Salvianolic acid B and sodium tanshinone II A sulfonate prevent pulmonary fibrosis through anti-inflammatory and anti-fibrotic process.
LncRNA Mical2/miR-203a-3p sponge participates in epithelial-mesenchymal transition by targeting p66Shc in liver fibrosis.
Paired box 9 regulates VSMC phenotypic transformation, proliferation, and migration via sonic hedgehog.
CTRP15 derived from cardiac myocytes attenuates TGFβ1-induced fibrotic response in cardiac fibroblasts.
Emodin inhibiting neutrophil elastase-induced epithelial-mesenchymal transition through Notch1 signalling in alveolar epithelial cells.
Polydeoxyribonucleotide-delivering therapeutic hydrogel for diabetic wound healing.
Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin.
IL-32 induces epithelial-mesenchymal transition by triggering endoplasmic reticulum stress in A549 cells.
P38 Inhibition Prevents Herpes Simplex Virus Type 1 (HSV-1) Infection in Cultured Corneal Keratocytes.
Inhibition of microRNA-150-5p alleviates cardiac inflammation and fibrosis via targeting Smad7 in high glucose-treated cardiac fibroblasts.
Cancer-associated fibroblasts induce epithelial-mesenchymal transition and cisplatin resistance in ovarian cancer via CXCL12/CXCR4 axis.
OXPHOS-dependent metabolic reprogramming prompts metastatic potential of breast cancer cells under osteogenic differentiation.
Depleting RhoA/Stress Fiber-Organized Fibronectin Matrices on Tumor Cells Non-Autonomously Aggravates Fibroblast-Driven Tumor Cell Growth.
Sirtuin 6 attenuates epithelial-mesenchymal transition by suppressing the TGF-β1/Smad3 pathway and c-Jun in asthma models.
Downregulation of lysyl oxidase in venous malformations: Association with vascular destabilization and sclerotherapy.
Generation and characterization of a human iPSC line derived from congenital clubfoot amniotic fluid cells.
Upregulation of KSRP by miR-27b attenuates schistosomiasis-induced hepatic fibrosis by targeting TGF-β1.
TSP-1 as a novel biological marker of tumor vasculature normalization in colon carcinoma induced by Endostar.
The mechanism and role of intracellular α-ketoglutarate reduction in hepatic stellate cell activation.
LTBP1 promotes esophageal squamous cell carcinoma progression through epithelial-mesenchymal transition and cancer-associated fibroblasts transformation.
Ophiocordyceps lanpingensis polysaccharides attenuate pulmonary fibrosis in mice.
Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78).
MiR-377-3p inhibits atherosclerosis-associated vascular smooth muscle cell proliferation and migration via targeting neuropilin2.
Exploring the potential of engineered exosomes as delivery systems for tumor-suppressor microRNA replacement therapy in ovarian cancer.
LncRNA NNT-AS1 promote glioma cell proliferation and metastases through miR-494-3p/PRMT1 axis.
Administration of a mixture of triterpenoids from yeyachun and phenolic acids from danshen ameliorates carbon tetrachloride-induced liver fibrosis in mice by the regulation of intestinal flora.
Elk-1 transcriptionally regulates ZC3H4 expression to promote silica-induced epithelial-mesenchymal transition.
Tensile force-induced PDGF-BB/PDGFRβ signals in periodontal ligament fibroblasts activate JAK2/STAT3 for orthodontic tooth movement.
Single-Cell Transcriptome Analysis Reveals Intratumoral Heterogeneity in ccRCC, which Results in Different Clinical Outcomes.
Nintedanib Reduces Neutrophil Chemotaxis via Activating GRK2 in Bleomycin-Induced Pulmonary Fibrosis.
TIM-4 interference in Kupffer cells against CCL4-induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway.
Subcellular trafficking of tubular MDM2 implicates in acute kidney injury to chronic kidney disease transition during multiple low-dose cisplatin exposure.
Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling.
Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function.
Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation.
Long non-coding RNA RNF7 promotes the cardiac fibrosis in rat model via miR-543/THBS1 axis and TGFβ1 activation.
Bleomycin induces epithelial-to-mesenchymal transition via bFGF/PI3K/ESRP1 signaling in pulmonary fibrosis.
Telmisartan inhibits oxalate and calcium oxalate crystal-induced epithelial-mesenchymal transformation via PPAR-γ-AKT/STAT3/p38 MAPK-Snail pathway.
Icariside II improves myocardial fibrosis in spontaneously hypertensive rats by inhibiting collagen synthesis.
SWI/SNF complex subunit BAF60a represses hepatic ureagenesis through a crosstalk between YB-1 and PGC-1α.
Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury.
Jiawei Yanghe decoction ameliorates cartilage degradation in vitro and vivo via Wnt/β-catenin signaling pathway.
Pluripotent hematopoietic stem cells augment α-adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension.
Establishment of a control induced pluripotent stem cell line SMBCi006-A from a healthy male donor.
miR-448-3p alleviates diabetic vascular dysfunction by inhibiting endothelial-mesenchymal transition through DPP-4 dysregulation.
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications.
Extracellular histones stimulate collagen expression in vitro and promote liver fibrogenesis in a mouse model via the TLR4-MyD88 signaling pathway.
β2-microglobulin as a biomarker of pulmonary fibrosis development in COPD patients.
Apremilast interferes with the TGFβ1-induced transition of human skin fibroblasts into profibrotic myofibroblasts: in vitro study.
Silencing of the lncRNA TUG1 attenuates the epithelial-mesenchymal transition of renal tubular epithelial cells by sponging miR-141-3p via regulating β-catenin.
LncRNA Gm16410 regulates PM(2.5)-induced lung Endothelial-Mesenchymal Transition via the TGF-β1/Smad3/p-Smad3 pathway.
Ammonia exposure causes lung injuries and disturbs pulmonary circadian clock gene network in a pig study.
Atorvastatin attenuates TGF‑β1‑induced fibrogenesis by inhibiting Smad3 and MAPK signaling in human ventricular fibroblasts.
Maladjustment of β-CGRP/α-CGRP Regulation of AQP5 Promotes Transition of Alveolar Epithelial Cell Apoptosis to Pulmonary Fibrosis.
WWP2 regulates SIRT1-STAT3 acetylation and phosphorylation involved in hypertensive angiopathy.
Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoholic fatty liver disease by up-regulating the FGF21/PGC-1α pathway.
Icotinib Attenuates Monocrotaline-Induced Pulmonary Hypertension by Preventing Pulmonary Arterial Smooth Muscle Cell Dysfunction.
Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease.
Trichostatin A Alleviates Renal Interstitial Fibrosis Through Modulation of the M2 Macrophage Subpopulation.
Regulation of NLRP3 inflammasome by CD38 through cADPR-mediated Ca(2+) release in vascular smooth muscle cells in diabetic mice.
Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-β1/Smads signaling in diabetic cardiomyopathy.
Icariside II attenuates eosinophils-induced airway inflammation and remodeling via inactivation of NF-κB and STAT3 in an asthma mouse model.
Activation of Sigma-1 Receptor Enhanced Pericyte Survival via the Interplay Between Apoptosis and Autophagy: Implications for Blood-Brain Barrier Integrity in Stroke.
Micro-vesicles from mesenchymal stem cells over-expressing miR-34a inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells in vitro.
The metastatic phenotype shift toward myofibroblast of adipose-derived mesenchymal stem cells promotes ovarian cancer progression.
Exosomal miR-125a-5p derived from silica-exposed macrophages induces fibroblast transdifferentiation.
Abnormal Ribosome Biogenesis Partly Induced p53-Dependent Aortic Medial Smooth Muscle Cell Apoptosis and Oxidative Stress.
Bufei Qingyu Granules Inhibit the Development of Systemic Sclerosis via Notch-1/Jagged-2 Signaling Pathway.
Methane-Rich Saline Counteracts Cholestasis-Induced Liver Damage via Regulating the TLR4/NF-κB/NLRP3 Inflammasome Pathway.
Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways.
Effects of Ethyl Pyruvate on Bile Duct Ligation-Induced Liver Fibrosis by Regulating Nrf2 Pathway and Proinflammatory Cytokines in Rats.
Human colorectal cancer-derived carcinoma associated fibroblasts promote CD44-mediated adhesion of colorectal cancer cells to endothelial cells by secretion of HGF.
Exosomal miRNA-139 in cancer-associated fibroblasts inhibits gastric cancer progression by repressing MMP11 expression.
Fructose-1,6-bisphosphate prevents pulmonary fibrosis by regulating extracellular matrix deposition and inducing phenotype reversal of lung myofibroblasts.
High-Mobility Group Box 1 Contributes to Cerebral Cortex Injury in a Neonatal Hypoxic-Ischemic Rat Model by Regulating the Phenotypic Polarization of Microglia.
Liraglutide Improves Non-Alcoholic Fatty Liver Disease In Diabetic Mice By Modulating Inflammatory Signaling Pathways.
Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/MyD88/NF-κB signaling pathway.
GPX2 suppression of H(2)O(2) stress regulates cervical cancer metastasis and apoptosis via activation of the β-catenin-WNT pathway.
Liraglutide ameliorates nonalcoholic fatty liver disease in diabetic mice via the IRS2/PI3K/Akt signaling pathway.
Antiproliferative and Immunoregulatory Effects of Azelaic Acid Against Acute Myeloid Leukemia via the Activation of Notch Signaling Pathway.
Differential regulation of vacuolar H(+) -ATPase subunits by transforming growth factor-β1 in salivary ducts.
The Akt/FoxO/p27(Kip1) axis contributes to the anti-proliferation of pentoxifylline in hypertrophic scars.
Adenovirus‑mediated overexpression of bone morphogenetic protein‑9 promotes methionine choline deficiency‑induced non‑alcoholic steatohepatitis in non‑obese mice.
Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression.
Exogenous angiotensin (1-7) directly inhibits epithelial-mesenchymal transformation induced by transforming growth factor-β1 in alveolar epithelial cells.
A novel technique to prepare a single cell suspension of isolated quiescent human hepatic stellate cells.
Altered bile acid composition and disposition in a mouse model of non-alcoholic steatohepatitis.
Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure.
Chrysophanol attenuates airway inflammation and remodeling through nuclear factor-kappa B signaling pathway in asthma.
Inhibition of vascular neointima hyperplasia by FGF21 associated with FGFR1/Syk/NLRP3 inflammasome pathway in diabetic mice.
Effects of ubiquitin-proteasome inhibitor on the expression levels of TNF-α and TGF-β1 in mice with viral myocarditis.
SPIO nanoparticle-labeled bone marrow mesenchymal stem cells inhibit pulmonary EndoMT induced by SiO(2).
Curcumin mitigates the epithelial-to-mesenchymal transition in biliary epithelial cells through upregulating CD109 expression.
Long non-coding RNA TUG1 promotes airway remodelling by suppressing the miR-145-5p/DUSP6 axis in cigarette smoke-induced COPD.
[Exogenous hydrogen sulfide improves erectile dysfunction by inhibiting apoptosis of corpus cavernosum smooth muscle cells in rats with cavernous nerve injury].
Artemisinin attenuates the development of atherosclerotic lesions by the regulation of vascular smooth muscle cell phenotype switching.
SPARC induces phenotypic modulation of human brain vascular smooth muscle cells via AMPK/mTOR-mediated autophagy.
Emergence of the Dedifferentiated Phenotype in Hepatocyte-Derived Tumors in Mice: Roles of Oncogene-Induced Epigenetic Alterations.
Inhibition of mitochondrial complex I activity attenuates neointimal hyperplasia by inhibiting smooth muscle cell proliferation and migration.
Histone deacetylase-1 as a prognostic factor and mediator of gastric cancer progression by enhancing glycolysis.
NAB 2-Expressing Cancer-Associated Fibroblast Promotes HNSCC Progression.
Ribes diacanthum Pall (RDP) ameliorates UUO-induced renal fibrosis via both canonical and non-canonical TGF-β signaling pathways in mice.
AKR1B10 (Aldo-keto reductase family 1 B10) promotes brain metastasis of lung cancer cells in a multi-organ microfluidic chip model.
Isolation and culture of vascular smooth muscle cells from rat placenta.
Death-associated protein kinase 3 deficiency alleviates vascular calcification via AMPK-mediated inhibition of endoplasmic reticulum stress.
Epidural adipose tissue-derived mesenchymal stem cell activation induced by lung cancer cells promotes malignancy and EMT of lung cancer.
The emerging roles of a novel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial to mesenchymal transition.
Beclin 1, LC3, and p62 expression in paraquat-induced pulmonary fibrosis.
c‑Jun N‑terminal kinase/transforming growth factor‑β/Smad3 pathway: Is it associated with endoplasmic reticulum stress‑mediated renal interstitial fibrosis?
miR-205-5p suppresses pulmonary vascular smooth muscle cell proliferation by targeting MICAL2-mediated Erk1/2 signaling.
Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.
HBOA ameliorates CCl(4)-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways.
Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro.
Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α Inhibits Vascular Calcification Through Sirtuin 3-Mediated Reduction of Mitochondrial Oxidative Stress.
Rhynchophylline attenuates allergic bronchial asthma by inhibiting transforming growth factor-β1-mediated Smad and mitogen-activated protein kinase signaling transductions in vivo and in vitro.
CDH11 promotes liver fibrosis via activation of hepatic stellate cells.
The deregulation of STIM1 and store operative calcium entry impaired aortic smooth muscle cells contractility in aortic medial degeneration.
Anti-senescence role of heterozygous fumarate hydratase gene knockout in rat lung fibroblasts in vitro.
Native nanodiscs from blood inhibit pulmonary fibrosis.
Autophagic flux blockage in alveolar epithelial cells is essential in silica nanoparticle-induced pulmonary fibrosis.
Indoxyl sulfate-induced calcification of vascular smooth muscle cells via the PI3K/Akt/NF-κB signaling pathway.
miR-194 suppresses epithelial-mesenchymal transition of retinal pigment epithelial cells by directly targeting ZEB1.
Label- and modification-free-based in situ selection of bovine serum albumin specific aptamer.
Knockdown of periostin attenuates 5/6 nephrectomy-induced intrarenal renin-angiotensin system activation, fibrosis, and inflammation in rats.
circPUM1 Promotes Tumorigenesis and Progression of Ovarian Cancer by Sponging miR-615-5p and miR-6753-5p.
Salusin-β Promotes Vascular Calcification via Nicotinamide Adenine Dinucleotide Phosphate/Reactive Oxygen Species-Mediated Klotho Downregulation.
Galectin-3 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension.
Calhex(231) Alleviates High Glucose-Induced Myocardial Fibrosis via Inhibiting Itch-Ubiquitin Proteasome Pathway in Vitro.
Expression and distribution of PIEZO1 in the mouse urinary tract.
Exploring the Mechanism of Dangguiliuhuang Decoction Against Hepatic Fibrosis by Network Pharmacology and Experimental Validation.
Salvianolic Acid A Attenuates Endoplasmic Reticulum Stress and Protects Against Cholestasis-Induced Liver Fibrosis via the SIRT1/HSF1 Pathway.
Monitoring the Process of Endostar-Induced Tumor Vascular Normalization by Non-contrast Intravoxel Incoherent Motion Diffusion-Weighted MRI.
Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2.
Glucagon-Like Peptide-1 Mediates the Protective Effect of the Dipeptidyl Peptidase IV Inhibitor on Renal Fibrosis via Reducing the Phenotypic Conversion of Renal Microvascular Cells in Monocrotaline-Treated Rats.
Engagement of circular RNA HECW2 in the nonautophagic role of ATG5 implicated in the endothelial-mesenchymal transition.
Zoledronate inhibits fibroblasts' proliferation and activation via targeting TGF-β signaling pathway.
Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways.
EDIL3 depletion suppress epithelial-mesenchymal transition of lens epithelial cells via transforming growth factor β pathway.
Thymosin β4 suppresses CCl(4) -induced murine hepatic fibrosis by down-regulating transforming growth factor β receptor-II.
Stromal expression of JNK1 and VDR is associated with the prognosis of esophageal squamous cell carcinoma.
Anterior gradient 2 as a supervisory marker for tumor vessel normalization induced by anti-angiogenic treatment.
Rab7 empowers renal tubular epithelial cells with autophagy-mediated protection against albumin-induced injury.
NMDA receptor activation inhibits the antifibrotic effect of BM-MSCs on bleomycin-induced pulmonary fibrosis.
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Octreotide attenuates hepatic fibrosis and hepatic stellate cells proliferation and activation by inhibiting Wnt/β-catenin signaling pathway, c-Myc and cyclin D1.
LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis.
Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells.
Hepatoprotection of auraptene from peels of citrus fruits against thioacetamide-induced hepatic fibrosis in mice by activating farnesoid X receptor.
Rotenone ameliorates chronic renal injury caused by acute ischemia/reperfusion.
circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1.
Propranolol prevents liver cirrhosis by inhibiting hepatic stellate cell activation mediated by the PDGFR/Akt pathway.
Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis.
Taurocholic acid is an active promoting factor, not just a biomarker of progression of liver cirrhosis: evidence from a human metabolomic study and in vitro experiments.
Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity.
Carnosic acid prevents COL1A2 transcription through the reduction of Smad3 acetylation via the AMPKα1/SIRT1 pathway.
8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo.
Hepatoprotective effects of ethyl pyruvate against CCl4-induced hepatic fibrosis via inhibition of TLR4/NF-κB signaling and up-regulation of MMPs/TIMPs ratio.
Epigallocatechin-3-gallate inhibits inflammation and epithelial‑mesenchymal transition through the PI3K/AKT pathway via upregulation of PTEN in asthma.
Toxoplasma gondii GRA15(II) effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica.
Nanoplatform Assembled from a CD44-Targeted Prodrug and Smart Liposomes for Dual Targeting of Tumor Microenvironment and Cancer Cells.
Metformin attenuates motility, contraction, and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase.
Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway.
Chemokine (C-X-C motif) ligand 1 is associated with tumor progression and poor prognosis in patients with colorectal cancer.
Lipopolysaccharide enhances TGF-β1 signalling pathway and rat pancreatic fibrosis.
Inhibition of lysyl oxidase-like 1 (LOXL1) expression arrests liver fibrosis progression in cirrhosis by reducing elastin crosslinking.
Upregulation of phosphatase and tensin homolog is essential for the effect of 4-aminopyridine on A549/CDDP cells.
Inhibition of tumor-promoting stroma to enforce subsequently targeting AT(1)R on tumor cells by pathological inspired micelles.
Protective effects of yangonin from an edible botanical Kava against lithocholic acid-induced cholestasis and hepatotoxicity.
5-aminoisoquinoline improves renal function and fibrosis during recovery phase of cisplatin-induced acute kidney injury in rats.
Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats.
Serum levels of WNT1-inducible signaling pathway protein-1 (WISP-1): a noninvasive biomarker of renal fibrosis in subjects with chronic kidney disease.
Carnosic Acid Alleviates BDL-Induced Liver Fibrosis through miR-29b-3p-Mediated Inhibition of the High-Mobility Group Box 1/Toll-Like Receptor 4 Signaling Pathway in Rats.
Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes.
Gypenosides Ameliorate Carbon Tetrachloride-Induced Liver Fibrosis by Inhibiting the Differentiation of Hepatic Progenitor Cells into Myofibroblasts.
Effects of Total Flavone from Rhododendron simsii Planch. Flower on Postischemic Cardiac Dysfunction and Cardiac Remodeling in Rats.
Anti-OSM Antibody Inhibits Tubulointerstitial Lesion in a Murine Model of Lupus Nephritis.
Recombined human endostatin (Endostar) enhances cisplatin delivery and potentiates chemotherapy by decompressing colorectal cancer vessels.
Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation.
The Hemoglobin Homolog Cytoglobin in Smooth Muscle Inhibits Apoptosis and Regulates Vascular Remodeling.
High doses of baicalin induces kidney injury and fibrosis through regulating TGF-β/Smad signaling pathway.
Inhibition of airway remodeling and inflammation by isoforskolin in PDGF-induced rat ASMCs and OVA-induced rat asthma model.
Codelivery for Paclitaxel and Bcl-2 Conversion Gene by PHB-PDMAEMA Amphiphilic Cationic Copolymer for Effective Drug Resistant Cancer Therapy.
Effect of pioglitazone on the calcification of rat vascular smooth muscle cells through the downregulation of the Wnt/β‑catenin signaling pathway.
Crocetin inhibits the proliferation, migration and TGF-β(2)-induced epithelial-mesenchymal transition of retinal pigment epithelial cells.
Galectin-3 mediates the pulmonary arterial hypertension-induced right ventricular remodeling through interacting with NADPH oxidase 4.
Production of human mutant biologically active hepatocyte growth factor in Chinese hamster ovary cells.
FAM3B mediates high glucose-induced vascular smooth muscle cell proliferation and migration via inhibition of miR-322-5p.
Role of heparin in pulmonary cell populations in an in-vitro model of acute lung injury.
Highly Selective Targeting of Hepatic Stellate Cells for Liver Fibrosis Treatment Using a d-Enantiomeric Peptide Ligand of Fn14 Identified by Mirror-Image mRNA Display.
Reactive oxygen species mediate angiotensin II-induced transcytosis of low-density lipoprotein across endothelial cells.
Generation and characteristics of human Sertoli cell line immortalized by overexpression of human telomerase.
Dual Function for Mature Vascular Smooth Muscle Cells During Arteriovenous Fistula Remodeling.
Secreted phospholipase A2 of Clonorchis sinensis activates hepatic stellate cells through a pathway involving JNK signalling.
Losartan Attenuates Scar Formation in Filtering Bleb After Trabeculectomy.
miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions.
NUBPL, a novel metastasis-related gene, promotes colorectal carcinoma cell motility by inducing epithelial-mesenchymal transition.
LncRNA-ATB/microRNA-200a/β-catenin regulatory axis involved in the progression of HCV-related hepatic fibrosis.
Clonorchis sinensis lysophospholipase A upregulates IL-25 expression in macrophages as a potential pathway to liver fibrosis.
Qi-Zhu-Xie-Zhuo-Fang reduces serum uric acid levels and ameliorates renal fibrosis in hyperuricemic nephropathy rats.
CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting Gα(12/13).
Conjugation of gold nanoparticles and recombinant human endostatin modulates vascular normalization via interruption of anterior gradient 2-mediated angiogenesis.
Knockdown of histidine-rich calcium-binding protein (HRC) suppresses liver fibrosis by inhibiting the activation of hepatic stellate cells.
Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor.
Interaction network of coexpressed mRNA, miRNA, and lncRNA activated by TGF‑β1 regulates EMT in human pulmonary epithelial cell.
Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model.
Atrial natriuretic peptide: A novel mediator for TGF-β1-induced epithelial-mesenchymal transition in 16HBE-14o and A549 cells.
The role of metastasis-associated in colon cancer 1 (MACC1) in endometrial carcinoma tumorigenesis and progression.
MicroRNA-99a inhibits insulin-induced proliferation, migration, dedifferentiation, and rapamycin resistance of vascular smooth muscle cells by inhibiting insulin-like growth factor-1 receptor and mammalian target of rapamycin.
MDM2 mediates fibroblast activation and renal tubulointerstitial fibrosis via a p53-independent pathway.
Inflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- Mice.
Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy.
MAD2B promotes tubular epithelial-to-mesenchymal transition and renal tubulointerstitial fibrosis via Skp2.
A comparison of incidences of bladder neck contracture of 80- versus 180-W GreenLight laser photoselective vaporization of benign prostatic hyperplasia.
Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE-/- mice.
IL-27 inhibits the TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells.
Lymph node metastasis of primary endometrial cancers: Associated proteins revealed by MALDI imaging.
MicroRNA-548a-5p promotes proliferation and inhibits apoptosis in hepatocellular carcinoma cells by targeting Tg737.
Carboxy-terminal modulator protein attenuated extracellular matrix deposit by inhibiting phospho-Akt, TGF-β1 and α-SMA in kidneys of diabetic mice.
In vitro differentiation of endometrial regenerative cells into smooth muscle cells: Α potential approach for the management of pelvic organ prolapse.
Gold Nanoparticle-Mediated Targeted Delivery of Recombinant Human Endostatin Normalizes Tumour Vasculature and Improves Cancer Therapy.
Effect of astragalus injection on renal tubular epithelial transdifferentiation in type 2 diabetic mice.
Clonorchis sinensis lysophospholipase inhibits TGF-β1-induced expression of pro-fibrogenic genes through attenuating the activations of Smad3, JNK2, and ERK1/2 in hepatic stellate cell line LX-2.
Mesenchymal stem cell-conditioned media suppresses inflammation-associated overproliferation of pulmonary artery smooth muscle cells in a rat model of pulmonary hypertension.
Apobec-1 Complementation Factor (A1CF) Inhibits Epithelial-Mesenchymal Transition and Migration of Normal Rat Kidney Proximal Tubular Epithelial Cells.
PTP1B confers liver fibrosis by regulating the activation of hepatic stellate cells.
IL-27 attenuates the TGF-β1-induced proliferation, differentiation and collagen synthesis in lung fibroblasts.
Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress.
miR-1273g-3p modulates activation and apoptosis of hepatic stellate cells by directly targeting PTEN in HCV-related liver fibrosis.
Quantitative Proteomic Analysis of Escherichia coli Heat-Labile Toxin B Subunit (LTB) with Enterovirus 71 (EV71) Subunit VP1.
The germline-enriched Ppp1r36 promotes autophagy.
C1q/tumor necrosis factor-related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting myofibroblast differentiation.
Valsartan Promoting Atherosclerotic Plaque Stabilization by Upregulating Renalase: A Potential-Related Gene of Atherosclerosis.
Ghrelin Attenuates Liver Fibrosis through Regulation of TGF-β1 Expression and Autophagy.
Stroma derived COL6A3 is a potential prognosis marker of colorectal carcinoma revealed by quantitative proteomics.
CD73 regulates vascular smooth muscle cell functions and facilitates atherosclerotic plaque formation.
Transarterial chemoembolization aggravated peritumoral fibrosis via hypoxia-inducible factor-1α dependent pathway in hepatocellular carcinoma.
Irradiated fibroblasts promote epithelial-mesenchymal transition and HDGF expression of esophageal squamous cell carcinoma.
miR-494 suppresses the progression of breast cancer in vitro by targeting CXCR4 through the Wnt/β-catenin signaling pathway.
CTRP3 attenuates post-infarct cardiac fibrosis by targeting Smad3 activation and inhibiting myofibroblast differentiation.
Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction.
Anti-pulmonary fibrotic activity of salvianolic acid B was screened by a novel method based on the cyto-biophysical properties.
Human Parechovirus 3 Meningitis and Fatal Leukoencephalopathy.
Beta-casomorphin-7 prevents epithelial-mesenchymal transdifferentiation of NRK-52E cells at high glucose level: Involvement of AngII-TGF-β1 pathway.
Involvement of cAMP-PKA pathway in adenosine A1 and A2A receptor-mediated regulation of acetaldehyde-induced activation of HSCs.
Hesperetin derivative-7 inhibits PDGF-BB-induced hepatic stellate cell activation and proliferation by targeting Wnt/β-catenin pathway.
Potent effects of dioscin against liver fibrosis.
Rosiglitazone inhibits TGF-β 1 induced activation of human Tenon fibroblasts via p38 signal pathway.
Regulating inflammation using acid-responsive electrospun fibrous scaffolds for skin scarless healing.
Endoplasmic reticulum stress-induced hepatic stellate cell apoptosis through calcium-mediated JNK/P38 MAPK and Calpain/Caspase-12 pathways.
Association between the hypomethylation of osteopontin and integrin β3 promoters and vascular smooth muscle cell phenotype switching in great saphenous varicose veins.
Identification of colonic fibroblast secretomes reveals secretory factors regulating colon cancer cell proliferation.
Upregulation of let-7a inhibits vascular smooth muscle cell proliferation in vitro and in vein graft intimal hyperplasia in rats.
Overexpression of c1q/tumor necrosis factor-related protein-3 promotes phosphate-induced vascular smooth muscle cell calcification both in vivo and in vitro.
Participation of miR-200a in TGF-β1-mediated hepatic stellate cell activation.
Effects and mechanism of dehydroepiandrosterone on epithelial-mesenchymal transition in bronchial epithelial cells.
Hyperthermia-conditioned OECs serum-free-conditioned medium induce NSC differentiation into neuron more efficiently by the upregulation of HIF-1 alpha and binding activity.
Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats.
Antifibrotic effect of curcumin in TGF-β 1-induced myofibroblasts from human oral mucosa.
MicroRNA-146a modulates TGF-beta1-induced hepatic stellate cell proliferation by targeting SMAD4.
β-Casomorphin-7 attenuates the development of nephropathy in type I diabetes via inhibition of epithelial-mesenchymal transition of renal tubular epithelial cells.
Fusion between cancer cells and myofibroblasts is involved in osteosarcoma.
BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2.
Chen YJ, Chen LY, Pham NT, Vega JLD, Fulgheri F, Wang CC, Manca ML, Lee CJ
International journal of medical sciences 2026;23(4):1491-1508
International journal of medical sciences 2026;23(4):1491-1508
Engineering exosomes with iRGD for targeted RNAi therapy against pancreatic cancer mediated by long non-coding RNA PLBD1-AS1.
Zhu W, Zhao X, Hao W, Zhou X, Ma C, Chen J, Zhao Y, Kong X, Du Y, Li L
PloS one 2026;21(4):e0345697
PloS one 2026;21(4):e0345697
Huanggan decoction ameliorates cholestatic hepatic fibrosis in rats via TGF-β1/Smad3 signaling pathway.
Lei Y, Ma X, Jin X, He Y, Yang J, Zhao Y, Chen J, Gao T
PloS one 2026;21(3):e0344168
PloS one 2026;21(3):e0344168
Arachidonic Acid-Induced Contraction of Smooth Muscle Is Mediated by MLC Phosphorylation in Preterm Birth.
Chen X, Chen J, Qiu J, Yan Y, Zhang R
Journal of pregnancy 2026;2026(1):e8266780
Journal of pregnancy 2026;2026(1):e8266780
PAPPA2 c.392G>C Heterozygous Mutation Associates Primary Open-Angle Glaucoma in a Chinese Family.
Wang G, Guo Z, Ren J, Zhang G, Tao H, Liu Y, Zheng S, Zhang X, Wang D, Zhao R, Cui H, Zhu S, Xu H, Duan S, Li H
Human mutation 2026;2026:5591097
Human mutation 2026;2026:5591097
Adipose Mesenchymal Stem Cells Promote Wound Healing by Modulating Expression of SERPINE1 in Dermal Fibroblasts and Keratinocytes.
Liang Y, Sun Q, Sun J, Xu M, Xu J, Yu Y
Stem cells international 2026;2026:5541440
Stem cells international 2026;2026:5541440
Targeting Pulmonary Hypertension: Elucidating Sophocarpine's Protective Role via Preclinical Models.
Xie F, Feng J, Li K, Chen Y, Han L, Wu Y
Mediators of inflammation 2026;2026:5524066
Mediators of inflammation 2026;2026:5524066
Integrated Mendelian Randomization and Single-Cell RNA Sequencing Analyses Reveal Lactate Metabolism as a Key Pathway in COVID-19-Induced Pulmonary Fibrosis.
Zhang X, Jia L, Yeziya T, Yang S, Chen M, Mo Y, Tong X, Zhang L
Canadian respiratory journal 2026;2026:1049336
Canadian respiratory journal 2026;2026:1049336
Imperatorin Alleviates Intestinal Fibrosis by Suppressing AIM2-mediated GSDMD Pyroptosis in Macrophages.
Li S, Zhu F, Xie Y, Ben T, Liu K, Lin X, Zhou Q, Zhang Y, Zhang X, Chen Y, Ren Y, Wang X, Zhi F, Tan G
Cellular and molecular gastroenterology and hepatology 2026;20(1):101625
Cellular and molecular gastroenterology and hepatology 2026;20(1):101625
Platelet-Rich Plasma Attenuates Knee Osteoarthritis in Rats via Modulation of Gut Microbiota.
Yan D, Li Q, Wang M, Nie Y, Sun X, Na L, Wang H
Drug design, development and therapy 2026;20:574392
Drug design, development and therapy 2026;20:574392
Berberine Ameliorates Diabetic Kidney Disease by Modulating Macrophage Polarization via Inhibiting IL-17A Signaling.
Fan J, Liu Y, Zheng C, Liu J, Liu W, Geng R, Zhao A, Wang Y, Wang R, Qi Z
Journal of inflammation research 2026;19:580534
Journal of inflammation research 2026;19:580534
FGF7-FGFR2 Signaling Enhances Contractile Activation of CAFs in Ovarian Cancer: Integrative Single-Cell and Spatial Transcriptomics.
Feng S, Ding Z, Wang Y, Zhu Z, Zhong W, Zhang K, Zhang Y, Chen L, Ma Y
Journal of inflammation research 2026;19:571158
Journal of inflammation research 2026;19:571158
The mTOR Inhibitor Rapamycin Attenuates Ozone-Induced Airway Inflammation and Emphysema In Mice.
Tian X, Han L, Huang Y, Zhou Y, Zhang X, Zhang M
Journal of inflammation research 2026;19:545564
Journal of inflammation research 2026;19:545564
PLA-THF-PEG nanoparticles Co-encapsulating AV3 and KH3 for synergistic pancreatic cancer therapy via stromal remodeling and metabolic inhibition.
Liu X, Hu Y, Yu J, Xue Y, He X, Jiang F
Frontiers in pharmacology 2026;17:1723694
Frontiers in pharmacology 2026;17:1723694
Luteolin mitigates proliferative vitreoretinopathy through inhibition of ERK1/2 signaling and epithelial-mesenchymal transition.
Wu L, Chen M, Chai J, Tang Y, Xu Q
Frontiers in pharmacology 2026;17:1634617
Frontiers in pharmacology 2026;17:1634617
Stem cell therapy targets THBS1 to reverse endometrial fibrosis.
Yu X, Shi L, Qu M, Zhang Y, Zhang Y, Xu X, Liu L, Wang H, Wang H
Frontiers in cell and developmental biology 2026;14:1766915
Frontiers in cell and developmental biology 2026;14:1766915
An astragalus polysaccharide-loaded hydrogel dressing enhances diabetic wound healing via dual-mode electrical stimulation.
Chen Z, Huo X, Wu Z, Ji G, Liu B, Tian H, Tang T, Deng J, Zhao Q, Li F
Bioactive materials 2026 Sep;63:885-903
Bioactive materials 2026 Sep;63:885-903
Elevated lactate production exacerbates PM2.5-induced pulmonary fibrosis by stabilizing TGF-β1.
Liu Z, Liu W, Wei H, Ping Y, Yu Z, Dong Z, Ren J, Zhang S, Liu S
Journal of advanced research 2026 May;83:299-314
Journal of advanced research 2026 May;83:299-314
Ginsenoside Rg1 Improves Cardiac Function and Ventricular Remodelling by Down-Regulating SH2B Adaptor Protein 1 Expression in Rats With Myocardial Infarction.
Xiang N, Hu J, Luo X
Clinical and experimental pharmacology & physiology 2026 May;53(5):e70121
Clinical and experimental pharmacology & physiology 2026 May;53(5):e70121
RNF220 mediates K63-linked polyubiquitination of STAT3 and aggravates pathological cardiac hypertrophy.
Gao Y, Zhao Z, Chen X, Li N, Li Y, Guan J, Dai H
Cell death and differentiation 2026 May;33(5):945-958
Cell death and differentiation 2026 May;33(5):945-958
Long non‑coding RNA NKILA regulates the JAK2/STAT3 pathway to exacerbate TGF‑β1‑mediated renal fibrosis.
Han Y, Yang S, Zhang J, Wang Y, Zhao X, Liu H
Molecular medicine reports 2026 May;33(5)
Molecular medicine reports 2026 May;33(5)
Acox1 induces lipid peroxidation and metabolic shifting to promote PASMCs proliferation in hypoxia-induced pulmonary hypertension.
Liang Q, Wang Y, Zhang X, Guo D, Qu G, Sun N, Xu J, Niu X, Liu Y, Geng J, Luo H, Wang C, Xin M, Wang X, Li Y, Jin F, Hu L
Free radical biology & medicine 2026 May;248:469-484
Free radical biology & medicine 2026 May;248:469-484
BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer-Associated Fibroblasts Crosstalk.
Shi HZ, Wu MY, Liu JQ, Tian C, Ma L, Zhou XM, Sun ZH, Xu ZY, Zhang RD, Ye SY, Huang LM, Wang Y, Xiong JS, Bu WB, Cheng XF, Sun JF, Chen H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(28):e14590
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(28):e14590
Effect of TGFβ-ITGB6 feedback loop on liver metastasis in SMAD4 wild-type pancreatic cancer.
Zhao Y, Qin C, Zhao B, Li Z, Li T, Wang W
Chinese medical journal 2026 May 5;139(9):1388-1401
Chinese medical journal 2026 May 5;139(9):1388-1401
Multi-omics driven immune classification of colorectal cancer: Implications for immunotherapy efficacy prediction and enhancement with WNT signaling inhibition.
Hu C, Cai D, You W, Zhou Z, Liu J, Li CH, Lv MY, Gai BW, Chen C, Huang X, Wang RX, Wu XJ, Hu P, Gao F
Cancer letters 2026 May 28;646:218425
Cancer letters 2026 May 28;646:218425
Study on the anti-pulmonary fibrosis mechanism of Renshen Pingfei formula by inhibiting M2 macrophage polarization and regulating TGF - β/SMAD signaling pathway.
Hong L, Sun Y, Hou H, Zhang J, Shi W, Yang Y, Fan X, Zhu J
Journal of ethnopharmacology 2026 May 23;363:121465
Journal of ethnopharmacology 2026 May 23;363:121465
Sodium hyaluronate based multifunctional hydrogels delivering SiRNA for sustained silencing of SMAD3: A novel strategy to treat intrauterine adhesions.
Chen K, Wang J, Liu Q, Wang H, Ning X, Wang J, Hu X, Zong L, Wu L, Luo T, Huang J, Zheng S
Carbohydrate polymers 2026 May 15;380:125123
Carbohydrate polymers 2026 May 15;380:125123
Decoding the DKK1/CKAP4 signaling Axis: A novel mechanism driving Neointimal hyperplasia in arteriovenous fistulas.
Xu S, Liang L, Xu H, Wang Q, Wei K, Wang Z, Kong X
International immunopharmacology 2026 May 15;177:116520
International immunopharmacology 2026 May 15;177:116520
N-acetylglucosamine ameliorates the transition from acute kidney injury to chronic kidney disease by reducing the accumulation of lipid droplets.
Tang Z, Ou Z, Wan H, Tao M, Li X, Huang Y, Tan Q, Peng Q, Dong L, Zhao J
International immunopharmacology 2026 May 15;177:116463
International immunopharmacology 2026 May 15;177:116463
Danlong oral liquid alleviates airway remodeling in asthma by targeting the S1PR2/ROCK1/YAP signaling pathway in airway smooth muscle cells.
Zhou M, Xiang M, Li Y, Wang Z, Lin J
Journal of ethnopharmacology 2026 May 10;362:121347
Journal of ethnopharmacology 2026 May 10;362:121347
Xuefu Zhuyu decoction attenuates thoracic aortic dissection by regulating VSMC phenotypic switching and oxidative stress via the JAK2/STAT3/HIF-1α pathway.
Cheng-Wen L, Rong G, Yi-Fan J, Shou-Jia W, Si-Yi L, Chun-Yan L, Fan L, Xiao-Qiang L, Wei-Xun D, Fan S
Journal of ethnopharmacology 2026 May 10;362:121324
Journal of ethnopharmacology 2026 May 10;362:121324
Early CD201-high cancer-associated fibroblasts shape immunosuppression and suggest a therapeutic opportunity in triple-negative breast cancer.
Li M, Yang J, Cui Z, Pan X, Qiu Q, Sun Q, Li Z, Han X, Wang Y, Hu Y, Ma X, Wang J
International immunopharmacology 2026 May 1;176:116437
International immunopharmacology 2026 May 1;176:116437
Puerarin suppress adipogenesis and inflammation on orbital fibroblasts from patients with thyroid eye disease.
Ma L, Hou Z, Liu C, Jiang X, Zhang J, Liu H, Li D
Journal of endocrinological investigation 2026 Mar;49(3):547-559
Journal of endocrinological investigation 2026 Mar;49(3):547-559
Collagen III regulates the termination of liver regeneration by suppressing hepatocyte proliferation and promoting functional recovery
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Peng H, Chen Z, Zhang Q, Zhang Y, Yang P, Gong J, Zhao A
Molecular medicine reports 2026 Mar;33(3)
Molecular medicine reports 2026 Mar;33(3)
RNA-seq and ChIP-seq reveal microplastics induce endothelial-mesenchymal transition via HK2-mediated histone lactylation in pulmonary hypertension.
Long C, Lin M, Wang W, Liu Y, Huang Z, Xu Z
Vascular pharmacology 2026 Mar;162:107571
Vascular pharmacology 2026 Mar;162:107571
Coenzyme Q10 Mitigates Myocardial Infarction by Modulating HDAC4 O-GlcNAcylation.
Xie W, Gao X, Song S, Li N, Zhao L
BioFactors (Oxford, England) 2026 Mar-Apr;52(2):e70085
BioFactors (Oxford, England) 2026 Mar-Apr;52(2):e70085
Identification and Validation of MTFP1 as a Mitochondrial Target Restoring Dynamics and ECM Remodeling in Acute Myocardial Infarction.
Hu X, Bao H, Huang Y, Cao Z, Yang W, Huang C, Chen X, Chen Y, Chen B, Xia G, Yang X, Huang R, Chen Z
Current issues in molecular biology 2026 Mar 9;48(3)
Current issues in molecular biology 2026 Mar 9;48(3)
The m(5)C demethylase TET1 is identified as a key regulator of scleral remodeling in myopia.
Jia S, Yang L, Wei P, Yu J, Han G, Wang Y
Clinical epigenetics 2026 Mar 9;18(1)
Clinical epigenetics 2026 Mar 9;18(1)
Tubular Epithelia-Specific Deletion of MCP-1 Does Not Afford Protection Against Adriamycin-Induced Kidney Injury.
Bondi CD, Hartman HL, Gilbert JL, Stewart JA, Clayton DR, Tan RJ
International journal of molecular sciences 2026 Mar 6;27(5)
International journal of molecular sciences 2026 Mar 6;27(5)
Plasma-activated hydrogel promotes postoperative colonic anastomotic leak healing.
Deng X, Ren K, Min T, Ma Y, Peng Y, Wang S, Zhang B, Xie X, Nan Y, Tong S, Liu Y, Zhang Y, Li K, Wang W, Hao N, Zhang G, Dang C, Sun T, Zhu K, Zhang H
Journal of advanced research 2026 Mar 6;
Journal of advanced research 2026 Mar 6;
Inhalable lipid nanoparticles for macrophage-specific STING gene editing to ameliorate pulmonary fibrosis.
Wang Y, Liu X, Xuan W, Huang W, Zhu Y, Mao C, Liu Y
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Mar 6;
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Mar 6;
Network medicine modeling of the m⁶A regulatory landscape identifies a KLF6-WTAP axis as a therapeutic target in pulmonary fibrosis.
Xu C, Zhou Z, Lin Y, Zhang S, Cai S, Li B, Wang Z
Journal of translational medicine 2026 Mar 5;24(1)
Journal of translational medicine 2026 Mar 5;24(1)
TWIST1-Mediated Induction of AEBP1 in Fibroblast-Like Synoviocytes Activates Transforming Growth Factor β Signaling to Drive Angiogenesis and Promote Rheumatoid Arthritis.
Li Z, Cai M, Huang W, Wen X, Li Y, Sun J, Zhu C, Yang C, Chen Z
Arthritis & rheumatology (Hoboken, N.J.) 2026 Mar 5;
Arthritis & rheumatology (Hoboken, N.J.) 2026 Mar 5;
Shikonin alleviates high-fat diet-induced vascular aging and dysfunction by inhibiting oxidative stress and mitochondrial damage.
Ren GQ, Liu HJ, Guo YQ, He ML, Li J, Li ZX, Jia CH, Liu T, Yang J
Molecular biology reports 2026 Mar 4;53(1)
Molecular biology reports 2026 Mar 4;53(1)
Multifunctional NIR-Responsive Composite Hydrogel with Combinatorial Antibacterial and Regenerative Properties for Diabetic Wound Healing.
Ji S, Wang C, Song J, Shi H, Wan D, Huang C, Fu H, Cao X, Wu H, Yang J
Gels (Basel, Switzerland) 2026 Mar 31;12(4)
Gels (Basel, Switzerland) 2026 Mar 31;12(4)
Tailored Porous Bimetallic Nanozyme Platform for Full-Cycle Therapeutics of Intestinal Ischemia/Reperfusion.
Qiu C, Xian W, Wang M, Zhao G, Zhang Y, Zhou Z, Sheng B, Zhen Z, Liu X, Diao S, Tu M, Qiu C, Wang H, Zhang J, Zhu P, Li T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 31;:e20748
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 31;:e20748
Ginsenoside Rb1 alleviates endothelial dysfunction and vascular remodeling in preeclampsia via activation of the PI3K-Akt-eNOS pathway.
Jia W, Wang W, Zhang B, Wang C, Huang X
Scientific reports 2026 Mar 3;16(1)
Scientific reports 2026 Mar 3;16(1)
Sexual dimorphism in keratoconus: transcriptomic and hormonal mechanisms underlying stromal remodelling.
Sun Y, Li Q, Wu X, Yu X, Wang R, Sun B, Wang K, Yu Y, Chen S, Jiang D, Chen W
Eye and vision (London, England) 2026 Mar 3;13(1)
Eye and vision (London, England) 2026 Mar 3;13(1)
Platelet-rich plasma ameliorates knee osteoarthritis in rats by modulating the abundance of gut Lactobacillus murinus.
Sun X, Li Q, Wang M, Nie Y, Na L, Yan D, Wang H
Journal of drug targeting 2026 Mar 27;:1-10
Journal of drug targeting 2026 Mar 27;:1-10
Piezo-herbal microneedle patches enable wireless endometrial regeneration and fertility recovery.
Zhao R, Ni S, Yang M, Gu Z, Zhu Y
Journal of nanobiotechnology 2026 Mar 26;24(1)
Journal of nanobiotechnology 2026 Mar 26;24(1)
The potential impact of exosomal miR-484 on post-myocardial infarction angiogenesis using bioinformatics and experimental verification.
Wu D, Yang R, Cheng X, Guo Q, Gao Y, Chen M, Zhang D
BMC cardiovascular disorders 2026 Mar 23;26(1)
BMC cardiovascular disorders 2026 Mar 23;26(1)
YBX1 promotes angiogenesis after myocardial infarction by stabilizing HIF1α mRNA via m(6)A signaling.
Bi F, Yu T, Liu H, Cao M, He Y, Li J, Wang H, Kong C, Xiao H, Tian H, Liu F, Wu Y, Zhou Y, Shan H
iScience 2026 Mar 20;29(3):114810
iScience 2026 Mar 20;29(3):114810
Tannic Acid Achieves Rapid Scar-Free Corneal Healing by Chelating Excess Copper to Suppress Aberrant LOX-Mediated Fibrosis.
Cai M, Wang X, Sun S, Yuan Z, Wang Y, Hua X, Yuan X
Investigative ophthalmology & visual science 2026 Mar 2;67(3):13
Investigative ophthalmology & visual science 2026 Mar 2;67(3):13
Engineering NIR-II carbon dots through aniline extension with graphene and nitrogen enrichment for hepatobiliary theranostics.
Yang L, Li M, Peng Y, Zhou Y, Zou J, Liu H, Zhang W, Liu J, He P, Dai F, Zheng J, Lin J, Qu S, Lu Z, Liu G
Nature communications 2026 Mar 2;17(1)
Nature communications 2026 Mar 2;17(1)
Omics insights into MYBL2-promoted cancer stem-like cells driving ferroptosis resistance in hepatocellular carcinoma.
Chen Y, Li X, Luo C, Lin G, Zhou X, Wen Z, Su H, Meng W, Chen C, Lu J, Luo X, Jiang D, Liu H, Ning Z, Chen Y, Tam PK, Pan X
Journal of advanced research 2026 Mar 19;
Journal of advanced research 2026 Mar 19;
AG1295 Attenuates High-Glucose-Induced Proliferation, Migration, Phenotype Transition, and Interleukin-6 Expression in Human Corneal Stromal Fibroblasts.
Zheng Y, Jiang H, Wang J, Zhang Q, Wan Q, Wang Y
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2026 Mar 18;:10807683261433333
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2026 Mar 18;:10807683261433333
A core-shell microneedle platform for the spatiotemporal codelivery of dual-agent therapeutics precisely orchestrates diabetic wound healing.
Zhan Y, Zhang Z, Zhang Z, Lin M, Liu H, Abulimiti D, Aihemaiti S, Kan Y, Tan J, Chen X, Tao S
Journal of nanobiotechnology 2026 Mar 17;24(1)
Journal of nanobiotechnology 2026 Mar 17;24(1)
GDF15-Treated iPSC-MSC-Derived Exosomes Alleviate Fibrosis Post-Myocardial Infarction via Repression of the MFAP4/ERK/Drp1 Axis.
Qiu J, Han Q, Shen Y, Yang Q, Li Z, Hong Y, Zhao J, Lin F, Ma K, Hu B, Liang X, Zhang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 15;40(5):e71621
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 15;40(5):e71621
Renal Tubule-Specific Deletion of Nephrocystin 3 (Nphp3) Causes Infantile Nephronophthisis-like Phenotypes in Mice.
Du X, Wang C, Fang Y, Wang G, Zhai Y, Shen Q, Tang X, Xu H
International journal of molecular sciences 2026 Mar 15;27(6)
International journal of molecular sciences 2026 Mar 15;27(6)
A Soft Matrix Microenvironment Promotes Laterally Spreading Tumors via Oxidative Phosphorylation-Dependent Cell Adhesion.
Zhong J, Lu J, Li H, Zhong J, Luo X, Hu Y, Wang X, Wang P, Zhang Y, Wang Z, Lai Q, Chen Z, Mi W, San-To WT, Li W, Tan S, Cheng Q, Li R, Nie Y, Liu S, Huang B, Han Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 15;:e23872
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 15;:e23872
Integrative study reveals NR1D1 mediates Hedyotis diffusa's antifibrosis via hypoxia inducible factor-1/ammonia axis.
Xia SW, Liu H, Yang KY, Gao YJ, Zhang MR, Zhou JW, Kong DS, Wu HY, Zhang F, Chen L
World journal of gastroenterology 2026 Mar 14;32(10):115334
World journal of gastroenterology 2026 Mar 14;32(10):115334
A β-Glycine-Enhanced Poly(l-lactic acid) Biopiezoelectric Patch for Self-Powered Myocardial Infarction Therapy.
Sun W, Yin T, Wei R, Yang S, Liu Y, Nie X, Zhang Y, Hu Z, Wu Z
ACS applied materials & interfaces 2026 Mar 11;18(9):13585-13598
ACS applied materials & interfaces 2026 Mar 11;18(9):13585-13598
Dynamically responsive hydrogel with mechanical stimulation enhances diabetic wound healing via activation of Piezo1-mediated efferocytosis.
Tao Z, Li Z, Shao Y, Xiao Y, Fan X, Yang L, Sun Z, Cui T, Sun Z, Jiang J, Lian X, Guo X, Liu S, Ma X
Bioactive materials 2026 Jun;60:607-625
Bioactive materials 2026 Jun;60:607-625
Extracellular vesicle-mediated transcellular mitophagy as a modulatory target for moderate hyperoxia-induced alveolar developmental arrest in bronchopulmonary dysplasia.
Sun Y, Wang T, Yang Y, Wang R, Zhu B, Wang J, Liang G, Peng W, Zhang N, Guo X, Wang X
Free radical biology & medicine 2026 Jun;249:453-468
Free radical biology & medicine 2026 Jun;249:453-468
Atractylenolide I ameliorates acute-on-chronic liver failure (ACLF) by promoting autophagy and preserving mitochondrial function through mTOR inhibition.
Tang D, Tuo F, Chen J, Ding L, Wu YN, Wang R
Biochimica et biophysica acta. Molecular basis of disease 2026 Jun;1872(5):168197
Biochimica et biophysica acta. Molecular basis of disease 2026 Jun;1872(5):168197
Xueshuantong injection alleviates ischemic heart failure via targeting PFKP-mediated endothelial-to-mesenchymal transition.
Su L, Mo R, Dai Y, Wang Z, Lai S, Mo L, Jiang T, Li X, Chen M, Li Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158085
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158085
Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney fibrosis via the L-carnitine-SIRT3 axis.
Shan C, Szili-Torok T, Yue G, Zhang L, Morioka T, Ochi A, Xu J, Liu Z, Yu J, Huang L, Zhou X, Li F, Xu W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158080
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158080
SiO(2) dust induces the transformation of lung fibroblasts to myofibroblasts by activating the S1P-RhoA-YAP signaling pathway.
Zhang H, Huang F, Guan L, Zeng M
Toxicology in vitro : an international journal published in association with BIBRA 2026 Jun;114:106229
Toxicology in vitro : an international journal published in association with BIBRA 2026 Jun;114:106229
Xiaoyaosan ameliorates stress-induced MASH via modulating IL-1R1/RXRα-mediated liver-brain crosstalk.
Zhang Y, Luo X, Wu S, Qin Y, Xue Q, Ye W, Hou S, Liu B, Huang D, Yuan W, Ao H, Tong G, Liao M
Journal of ethnopharmacology 2026 Jun 28;365:121585
Journal of ethnopharmacology 2026 Jun 28;365:121585
Hyaluronic acid-based reactive oxygen species responsive nanocomposite hydrogel for sequential drug delivery and effective prevention of postoperative abdominal adhesions.
Gong Y, Xiao D, Zhang T, Shi X, Wang S, Huang Y, Zhao C
Carbohydrate polymers 2026 Jun 1;381:125148
Carbohydrate polymers 2026 Jun 1;381:125148
The immunomodulatory metabolite butyrate ameliorates renal fibrosis by restoring gut barrier integrity and suppressing the TGF-β1/Smad3 pathway.
Liu G, Sun Q, Yan Q, Tang F, Lai LS, De Li X
International immunopharmacology 2026 Jun 1;178:116557
International immunopharmacology 2026 Jun 1;178:116557
Silk fibroin nanofibers-GelMA hydrogel composite loaded with embryonic fibroblasts: A strategy for enhanced wound healing.
Bo Y, Zhou Z, Dong R, Sun L, Li C, Zhang L, Yan Y
Colloids and surfaces. B, Biointerfaces 2026 Jul;263:115581
Colloids and surfaces. B, Biointerfaces 2026 Jul;263:115581
DECR1 deficiency activates a lipid peroxidation-mitocytosis-mitochondrial dysfunction axis in trophoblasts to promote preeclampsia.
Zhang Q, Feng H, Chen R, Long Y, Chu W, Li Y, Dai W, Yao Q, Luo X, Li H, Qi H
Free radical biology & medicine 2026 Jul;250:1-15
Free radical biology & medicine 2026 Jul;250:1-15
Endothelial Foxp1 overexpression inhibits endothelial-to-mesenchymal transition via suppressing Notch pathway activation to attenuate valvular calcification in chronic kidney disease.
Wang X, Ding W, Wei C, Guan C, Zhang N, Xu L, Tang R, Xu Y, Wang L
Biochemical pharmacology 2026 Jul;249:117901
Biochemical pharmacology 2026 Jul;249:117901
SSD: Targeting inflammasome and oxidative stress as a therapeutic strategy in inflammatory diseases.
Zhao Y, Fu X, Zuo H, Wang X, Li S, Wu T, Cheng C, Xu M, Xu G
Biochimica et biophysica acta. General subjects 2026 Jul;1870(7):130956
Biochimica et biophysica acta. General subjects 2026 Jul;1870(7):130956
Curdione alleviates renal fibrosis through Fblim1-dependent inhibition of the TGF-β1/Smad3 signaling pathway.
Li Q, Ni Y, Li Z, Zou Y, Guo H, Wang H, Zhang Q, Wang L, Li J
The Journal of nutritional biochemistry 2026 Jul;153:110333
The Journal of nutritional biochemistry 2026 Jul;153:110333
FOXC2 regulates CYP1B1 transcription and activates the TGF-β/Smad pathway to promote pulmonary fibrosis.
Chen W, Peng J, Tang X, Xiao Y, Chen Y, Tang L, Ouyang S
Cellular signalling 2026 Jul;143:112445
Cellular signalling 2026 Jul;143:112445
The role of the IL-33/ST2/MAPK signalling pathway in macrophage polarisation and endometrial fibrosis.
Li G, Xu F, Luo S, Jin Y, Yuan L, Yang X, Xuan T, Liu D
International immunopharmacology 2026 Jul 1;180:116743
International immunopharmacology 2026 Jul 1;180:116743
From inhalation to systemic damage: Decoding the mechanistic cascade of silica nanoparticle-induced multi-organ toxicity.
Ban JQ, Ao LH, Gu HQ, Wei YG, Tian Q, He X, Zhao H, Li J
Toxicology 2026 Jan;519:154310
Toxicology 2026 Jan;519:154310
ND-630, an acetyl-CoA carboxylase inhibitor, prevents renal fibrosis in adenine-induced CKD mice.
Liu X, Peng Y, Wu S, Xu Y, Ye X, Lu J
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(2):2593-2605
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(2):2593-2605
Microenvironment-activatable nanoagent for real-time NIR-II monitoring and targeted therapy of arterial restenosis.
Meng X, Song J, Meng H, Liao C, Yin Z, Gong K, Kong D, Qi J, Duan Y
Biomaterials 2026 Jan;324:123482
Biomaterials 2026 Jan;324:123482
Metabolic and epigenetic abnormalities cause hepatic fibrogenesis in metabolic dysfunction-associated steatohepatitis model mice.
Miura A, Ikeda S, Kono Y, Kawate K, Hosono T, Seki T
The Journal of biological chemistry 2026 Jan;302(1):110959
The Journal of biological chemistry 2026 Jan;302(1):110959
ACLP promotes hypertrophic scar pathogenesis by enhancing myofibroblast activation and cholesterol synthesis-related gene expression.
Shi Y, Song Y, Wang T, Jiao Y, Dang J, Zhang Y, Xiao S, Song B, Yu Z
Pathology, research and practice 2026 Jan;277:156311
Pathology, research and practice 2026 Jan;277:156311
Fe-Mn-IGF-AMD nanoparticles in accurate detection and treatment of liver cirrhosis via regulating relaxation coefficients and attenuating hepatocyte senescence.
Wang B, Ji T, Zhang Z, Duan Y, Xing Z, Duan J, Zhao S, Jia Y, Wang Q
Colloids and surfaces. B, Biointerfaces 2026 Jan;257:115182
Colloids and surfaces. B, Biointerfaces 2026 Jan;257:115182
QiShenYiQi dripping pills ameliorate post-myocardial infarction cardiac fibrosis via modulation of the cAMP/Rap1 and PI3K/Akt signaling pathways.
Liu Z, Chen S, Fu H, Li K, Liu H, Qin L, Wang L, Jin J, Yin L, Chen J
Fitoterapia 2026 Jan;188:107020
Fitoterapia 2026 Jan;188:107020
Yujie recipe attenuates bleomycin-induced pulmonary fibrosis via suppressing NF-κB/NLRP3 signaling in a Nrf2-dependent manner.
Qin L, Zhao B, Xiong Y, Chen L, Qi S, Ma Y, Zeng H, Song Y, Liu W, Tian T, Ge G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157607
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157607
Chronic PET-Microplastic Exposure: Disruption of Gut-Liver Homeostasis and Risk of Hepatic Steatosis.
Park S, Kim MJ, Shin JH, Kim E, Son M, Lee S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e12030
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e12030
SLC22A17 affects the development of urethral stricture by promoting ferroptosis and inhibiting the activation of fibroblasts.
Liang T, Deng C, Guo H, Dai Z, Lu Y, Jiang Y, Chen W
Biochemical and biophysical research communications 2026 Jan 8;795:153118
Biochemical and biophysical research communications 2026 Jan 8;795:153118
Mesenchymal stromal cells ameliorate systemic sclerosis-interstitial lung disease via PD-1/PD-L1 signalling axis.
Chen Y, Zhu H, Zhang Y, Liu M, Wu Y, Ding S, Wang D, Sun L
RMD open 2026 Jan 6;12(1)
RMD open 2026 Jan 6;12(1)
Mechanistic insights into miR-4775-mediated regulation of pancreatic cancer cell invasion and migration through BRMS1L.
Song Y, Han B, Liu Q, Fan R, Yang X
Hereditas 2026 Jan 5;163(1):20
Hereditas 2026 Jan 5;163(1):20
Integrative multiomics analysis reveals the ameliorative effects of Xiasangju on metabolic dysfunction-associated steatohepatitis.
Xiang F, He Z, Yang C, Lin L, Peng Q, Zhang Z
Chinese medicine 2026 Jan 4;21(1):3
Chinese medicine 2026 Jan 4;21(1):3
Ganoderma leucocontextum ethanol extract alleviates silica-induced pulmonary injury via TGF-β1/RUNX3/SMADs pathway.
Qian R, Xu Y, Zhang L, Wang L, Chen X, Yao Y, Xie L
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120757
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120757
Artemisinin-hydroxychloroquine combination from traditional antimalarial medicine attenuates pulmonary fibrosis via PI3K/AKT/GSK3β-mediated inhibition of epithelial-mesenchymal transition.
Zhang L, Yu L, Deng D, Liang Q, Du H, Mei M, Deng C, Song J, Guo W
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120717
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120717
Design of RGD-functionalized GSH-responsive pegylated polymeric protacs for selective BRD4 degradation and EndMT-driven cardiac fibrosis inhibition.
Bi T, Chen L, Wang T, Miao W, Zhai S, Huang R, Sun Q, Chen Y, Su H, Zhou J, Li R, Huang W, Yao X, Luo P, Liu Z
Journal of nanobiotechnology 2026 Jan 30;24(1)
Journal of nanobiotechnology 2026 Jan 30;24(1)
Activation of PBK by Gal-3 contributes to pulmonary artery hypertension by promoting PRC1 activation.
Zhang J, Liu J, Chen Y, Chen H, Meng Y, Wang Y, Qiu Y, Hu H, Shi W, Li M
Respiratory research 2026 Jan 29;27(1):65
Respiratory research 2026 Jan 29;27(1):65
Tanshinone IIA accelerates diabetic wound healing via suppression of macrophage NLRP3 inflammasome activity.
Pan T, Zhu X, Sui Y, Zhang Z, Su Y
Biochemical and biophysical research communications 2026 Jan 25;797:153171
Biochemical and biophysical research communications 2026 Jan 25;797:153171
Mechanistic Evaluation of Roxadustat for Pulmonary Fibrosis: Integrating Network Pharmacology, Transcriptomics, and Experimental Validation.
Zhang C, Huang X, Ye H, Tang H, Huang M, Jia S, Shao J, Wu J, Yao X
Pharmaceuticals (Basel, Switzerland) 2026 Jan 20;19(1)
Pharmaceuticals (Basel, Switzerland) 2026 Jan 20;19(1)
PARP1 stabilizes FOXN3 to suppress pulmonary fibrosis through p38-related feedback regulation.
Zhu X, Huo Q, Jin L, Du J, Yu J, Wang H, Wu N, Li Y, Rui Y, Zhao C, Zhou J, Zhang Y, Li H, Lin J, Zheng C, Li W
Science advances 2026 Jan 2;12(1):eady1681
Science advances 2026 Jan 2;12(1):eady1681
IL-36 participated in airway remodeling in chronic asthma model by inducing epithelial-mesenchymal transition process.
Zhang M, Cen J, Gan W, Feng K, Yang H, Zou X, Li H, Zhang T
European journal of medical research 2026 Jan 15;31(1):225
European journal of medical research 2026 Jan 15;31(1):225
Targeting sorting nexin 3 to treat pulmonary fibrosis by dual modulating Wnt/β-catenin signaling.
Ma D, Yu W, Zhou H, Lin R, Sun X, Peng M, Lin C, Du H, Li Y, Liang H, Sun D, Liu P, Lu J
Cell death & disease 2026 Jan 15;17(1):43
Cell death & disease 2026 Jan 15;17(1):43
Ecliptasaponin A alleviates inflammation and fibrosis in experimental MASH mice via targeting the NLRP3 inflammasome and YAP signaling pathway.
Gao K, Zhang W, Zhao M, Xu D, Tao X, Guo C, Du Y, Jin F, Li W, Liu M, Lu Y, Wang J
Chinese medicine 2026 Jan 13;21(1):32
Chinese medicine 2026 Jan 13;21(1):32
Cuproptosis of bronchial epithelial cells triggers airway remodeling in chronic asthma.
Wang M, Liu C, Li Z, Wang Y, Li Y, Pei F
Scientific reports 2026 Jan 13;16(1):4621
Scientific reports 2026 Jan 13;16(1):4621
Interorganelle competition for linoleic acid underlies steatotic liver pathology.
Zhang C, Yang D, Suzuki H, Dias do Vale G, Chen J, Vaidya A, Melikov K, Swisher A, Wang J, Ye M, Zhou J, Zeng Q, Bai M, Lin MJ, Lee J, Zhu H, Siegwart DJ, Hoshida Y, McDonald JG, Zeng X
bioRxiv : the preprint server for biology 2026 Jan 11;
bioRxiv : the preprint server for biology 2026 Jan 11;
Huashi Baidu granules alleviates LPS-induced acute lung injury by targeting TACE-mediated inflammatory signaling and stress granules disassembly.
Ma Y, Zhang J, Gong J, Yang W, Huang J, Sun Y
Journal of ethnopharmacology 2026 Jan 10;354:120580
Journal of ethnopharmacology 2026 Jan 10;354:120580
Guiqi Yishen granule alleviates obstructive nephropathy-induced renal fibrosis by targeting PI3K/AKT signaling pathway.
Zhu J, Cao S, Wang T, Wang N, Yang L, Tang X, Jiang M, Zhu Q, Yu H, Wu D, Peng WX
Journal of ethnopharmacology 2026 Jan 10;354:120490
Journal of ethnopharmacology 2026 Jan 10;354:120490
Potential regulators and metabolic networks of muscle fatty infiltration: genomic and radiomics investigation based on 33 300 participants.
Tan J, Ding Z, Zheng J, Zhang J, Chen X, Li Z, Shi L, Chen J, Sun Y
International journal of surgery (London, England) 2026 Jan 1;112(1):472-485
International journal of surgery (London, England) 2026 Jan 1;112(1):472-485
Melatonin alleviates cholestatic liver injury through modulating gut microbiota and activating the NRF2/HO-1 antioxidant pathway.
Dong S, Liu J, Xuan C, Zhou S, Han Z, Zhu C, Chen N, Liu R, Wang W, Chu H, Zhang X, Yang H, Liu M, Guo L, Zhou L
Tissue & cell 2026 Feb;98:103131
Tissue & cell 2026 Feb;98:103131
Mechanism of Curcumin in the Treatment of Intrauterine Adhesions Based on Network Pharmacology, Molecular docking, and Experimental Validation.
Li Q, Zhang Y, Shen H, Wang Z, Huang J, Tang S, Chen P, Zhi Z
Biochemical genetics 2026 Feb;64(1):591-610
Biochemical genetics 2026 Feb;64(1):591-610
Shionone ameliorates pulmonary fibrosis by activating mitophagy via PINK1-Parkin pathway.
Su Y, Fu Q, Wu X, Che X, Jiang Z, Li X
Toxicology and applied pharmacology 2026 Feb;507:117693
Toxicology and applied pharmacology 2026 Feb;507:117693
BMP1 inhibitor UK383367 improves MI-induced cardiac remodeling and fibrosis in mice via ameliorating macrophage polarization and mitochondrial dysfunction.
Guo CH, Wang QQ, Li JQ, Ji W, Chen L, Chang ML, Ma LY, Liu XL, Ni M
Acta pharmacologica Sinica 2026 Feb;47(2):315-327
Acta pharmacologica Sinica 2026 Feb;47(2):315-327
Genistein Ameliorates the Ischemic State of Random Skin Flap by Regulating Macrophage Polarization Through AMPK/SIRT1 Signaling Pathway.
Fu Y, Ye C, Zhu Y, Chen T, Li Z, Chen Y
Phytotherapy research : PTR 2026 Feb;40(2):420-435
Phytotherapy research : PTR 2026 Feb;40(2):420-435
Targeting single-cell multiomics-identified vascular impairment: Panax notoginseng extracellular vesicles-loaded adhesive QBK-2/EVs promotes angiogenesis in diabetic wound healing.
Xia F, Li X, Wen X, Chen B, Wu G, Ye X, Sun Y, Liu X, Fan L, Wang Y, Yang S, Ye P, Ding H
Materials today. Bio 2026 Feb;36:102714
Materials today. Bio 2026 Feb;36:102714
Modulation of endothelial-to-mesenchymal transition via NRP-1 targeting with melittin attenuates pulmonary fibrosis.
Hu M, Wan Y, Chen J, Zhang C, Li S, Shan B, Wu L, Yu X
Materials today. Bio 2026 Feb;36:102659
Materials today. Bio 2026 Feb;36:102659
Depletion of FOXO4 promotes the development of nonalcoholic fatty liver disease by aggravating high-fat diet-induced liver injury by increasing SPP1 expression.
Huang L, Qian G, Zhang A, Xu L, Wang S, Gao Y, Li W, Wang D, Hou M, Lv H
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2026 Feb;27(1):51-60
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2026 Feb;27(1):51-60
Engineered probiotics for the in vivo mitigation of waterborne uranium toxicity and bioaccumulation.
Li H, Zhang F, Wang C, Cui Z, Liu Y, Song Z, Yuan L, Chen X, Wu Y, Wu W, Tian L
Environment international 2026 Feb;208:110127
Environment international 2026 Feb;208:110127
L-tetrahydropalmatine attenuates methamphetamine-induced pulmonary vascular remodeling via CaSR-BMP2/mTOR signaling.
Chen L, Wang X, Zhu X, Hu WT, Yang D, Wang Y
Bioorganic chemistry 2026 Feb;169:109418
Bioorganic chemistry 2026 Feb;169:109418
Engineered Gadolinium-Decorated Magnetic Resonance Nanoprobes for Enhanced Liver Fibrosis Theranostics.
Wang Y, Zhang Q, Yan B, Pang L, Ren Y, Inam M, Zhang M, Ni N, Xu X, Sun X, Zhou S
Advanced healthcare materials 2026 Feb;15(8):e03891
Advanced healthcare materials 2026 Feb;15(8):e03891
Bioresponsive Nar-Zn@GelMA Hydrogel Reprograms the Diabetic Wound Microenvironment via Antioxidant and Immunoregulatory Synergy.
Hu S, Yuan T, Zhao C, Huang W, Ding W, Peng K, Wang G, Xie L
Advanced healthcare materials 2026 Feb;15(5):e03417
Advanced healthcare materials 2026 Feb;15(5):e03417
siRASA1 in vascular endothelial cells alleviates subretinal fibrosis through inhibiting macrophage-myofibroblast transdifferentiation via SHH signaling pathway.
Jiang L, Xu Z, Ma J, Cai W, Lin R, Hu C, Luo Y, Liang F, Wu Y, Yu J
Cellular signalling 2026 Feb;138:112261
Cellular signalling 2026 Feb;138:112261
DOT1L promotes phenotypic transition of vascular smooth muscle cells following vascular injury in diabetes through activation of the FGFR4/PI3K/AKT/Jag/Notch signaling pathway.
Zhang J, Wu D, Cheng C, Yang Z, Chen Z, Liu L, Li W, Wang W, Huang C, Yang J
Cellular signalling 2026 Feb;138:112223
Cellular signalling 2026 Feb;138:112223
Autocrine Netrin-1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet-Induced Metabolic Dysfunction-Associated Steatohepatitis in Mice.
Zhao J, Peng Y, Lei H, Wang T, Wang H, Wang B, Li J, Li X, Xiong X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e14545
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e14545
Activating the Osteoblastic USP26 Pathway Alleviates Multi-Organ Fibrosis by Decreasing Insulin Resistance.
Tang J, Ye W, He L, Dan Z, Chang L, You Z, Jiang Y, Tang G, Deng L, Li C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e12424
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e12424
Construction of a Novel Mucin/Tannic Acid Hydrogel for Diabetic Wound Repair.
Yue Y, Chen G, Cui X, Liao Y, Liu Z, Yang D
Journal of biomedical materials research. Part A 2026 Feb;114(2):e70044
Journal of biomedical materials research. Part A 2026 Feb;114(2):e70044
Discovery of novel small molecule inhibitor targeting the tumor promoting effect of transcription factor PLAGL2.
Ding Y, Wang Z, Xia X, Wang J, Li Z, Gu C, Hao C, Xu K, Gao M, Yin H, Chen S, Gong X, Zhou W, Zhang M, Yang Y, Zhang D, Dai B, Zhang M
European journal of medicinal chemistry 2026 Feb 5;303:118471
European journal of medicinal chemistry 2026 Feb 5;303:118471
Treadmill running modulates infrapatellar fat pad remodeling in osteoarthritic rats in an intensity-dependent manner.
Chen Z, Li G, Deng H, Hu Z, Wang Q, He Z
BMC sports science, medicine & rehabilitation 2026 Feb 5;18(1)
BMC sports science, medicine & rehabilitation 2026 Feb 5;18(1)
Integrated metabolomics and 16S rRNA sequencing reveal the mechanism of total flavones of Abelmoschus manihot (L.) Medic against liver fibrosis.
Li D, Ge H, Zhang Y, Song S, Xing L, Tang EH, Wang F
Scientific reports 2026 Feb 5;16(1)
Scientific reports 2026 Feb 5;16(1)
Uncovering a Glaucoma-Linked Lysophosphatidic Acid-MAPK/AP-1 Fibrosis Axis in Human Trabecular Meshwork Cells and Its Modulation by Diospyros kaki Leaf Extract.
Jeon Y, Kwon H, Ahn HR, Huh G, Kim T, Park YT, Park HB, Jeong JH, Jo JH, Kim YJ, Jung SH
International journal of molecular sciences 2026 Feb 4;27(3)
International journal of molecular sciences 2026 Feb 4;27(3)
Exosomal microRNAs of tuberculous pleural effusion orchestrating TGF-β signaling mediate pleural fibrosis.
Jiang LJ, Zheng YY, Liang LM, Jia ZH, Du RH, Huang H, Dai X, Cheng PP, Zhao LQ, Li Q, Jiang YH, Cui XL, Ye SY, Hu SH, Zhang HD, Lian CY, Feng X, Song LJ, Yu F, He XL, Xiong L, Xiang F, Wang X, Liu AD, Wang M, Ye H, Ma WL
Respiratory research 2026 Feb 3;27(1)
Respiratory research 2026 Feb 3;27(1)
Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease.
Fu T, Sun S, Wang Z, Zhao F, Zhen J, Ji X, Xue F, Mu Q, Wang Y, Liu Y, Wan Q
Cardiovascular diabetology 2026 Feb 3;25(1)
Cardiovascular diabetology 2026 Feb 3;25(1)
Fibroblast Growth Factor 11 Improves Fertility by Alleviating Intrauterine Adhesionss in Rats Through Inhibition of the Transforming Growth Factor-β1/Smad Pathway.
Yin F, Fang Q, Liu X, Yu X, Rong Y, Shi D, Xu Z, Gong F, Chen M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71602
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71602
Targeted inhibition of RGS19 alleviates renal fibrosis by restoring autophagy and modulating immune cell infiltration.
Niu X, Zhao Y, Li L, Xu X, Xu C, Wu J, Yu X, Chen Y, Rong R, Xu B
Journal of nanobiotechnology 2026 Feb 28;24(1)
Journal of nanobiotechnology 2026 Feb 28;24(1)
Role of CTGF-LRP1 in impaired healing of cesarean section incisions.
He C, Ge S, Xia W, Wang Y, Yan L, Sun J, Yan L, Zhu Q, Zhao X, Zhang J
Nature communications 2026 Feb 28;17(1)
Nature communications 2026 Feb 28;17(1)
Hydroxytyrosol Prevents Metabolic-Associated Steatohepatitis by Inhibiting SOCS2-Mediated Ferroptosis in High-Fat Diet Mice.
Yi D, Wu Z, Li X, Shao B, Xiao Y, Li T, Zhang X, Zhu J, Yang T, Deng Y, Huang T, Qiu T, Bai J, Shi X, Wu C, Wu Z, Sun X, Wang N
Journal of agricultural and food chemistry 2026 Feb 25;74(7):6265-6277
Journal of agricultural and food chemistry 2026 Feb 25;74(7):6265-6277
Cancer-Associated fibroblasts regulate the development of cholangiocarcinoma through IL-6/STAT3/AKR1C3 signaling axis.
Huang TC, Feng WD, Fang GX, Zhang QH, Wei GY, Li CZ, Wang JM, Liu JF
Scientific reports 2026 Feb 25;16(1)
Scientific reports 2026 Feb 25;16(1)
Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome.
Duan R, Wang X, Wang Q, Zhou X, Gao S, Sun Y, Feng Q, Li Z, Yang Z, Ding J, Chen Z, Duan J, Yang Y
Cell reports 2026 Feb 24;45(2):116942
Cell reports 2026 Feb 24;45(2):116942
Exosomes derived from bone marrow mesenchymal stem cells facilitate repair of radiation-Induced skin injury by attenuating inflammation and apoptosis.
Wen Y, Song Y, Pan S, Zhang N, Tong X
Scientific reports 2026 Feb 2;16(1):6918
Scientific reports 2026 Feb 2;16(1):6918
STING deficiency alleviates scar formation after glaucoma filtration surgery by suppressing p38 MAPK-induced inflammation in mice.
Ye H, Lu X, Chen H, Yang X, Xu H, Huang L, Zheng Q, Le R, Liang Y
Eye and vision (London, England) 2026 Feb 2;13(1):7
Eye and vision (London, England) 2026 Feb 2;13(1):7
LAPTM5 potentiates airway remodeling by regulating MAPKs-mediated airway smooth muscle cells' dysfunction.
Jiang L, Ying Y, Jin H, Zhou T
Mammalian genome : official journal of the International Mammalian Genome Society 2026 Feb 16;37(1):36
Mammalian genome : official journal of the International Mammalian Genome Society 2026 Feb 16;37(1):36
Ultraviolet-induced Glycyrrhiza polysaccharide hydrogels with different mechanical strength for wound management.
Wang Z, Luo M, Ni L, Li Y, Liu D, Zhu H, Xia B, Liu Y, Liu Q, Yang B
Carbohydrate polymers 2026 Feb 15;374:124712
Carbohydrate polymers 2026 Feb 15;374:124712
Formononetin inhibits p53 signaling pathway activation to delay cellular senescence and ameliorates diabetic kidney disease.
Ji Y, Liu RX, He PY, Zhou YM, Li YC, Guo J, Nie B, Liu YN, Liu WJ
World journal of diabetes 2026 Feb 15;17(2):112500
World journal of diabetes 2026 Feb 15;17(2):112500
FKBP10 as a prognostic biomarker and therapeutic target in hepatocellular carcinoma.
Xie X, Li J, Zhang AQ, Wu L, Wu C, Tang PM, Liu X
Discover oncology 2026 Feb 15;17(1)
Discover oncology 2026 Feb 15;17(1)
The Ets2 super-enhancer modulates endothelial-mesenchymal transition during cardiac ageing.
Guo Z, Li L, Luo J, Xue W, Bian S, Zhu Y, Huo D, Yang W, Ma J, Hao Y, Fan G, Hao B, Liao S
Cardiovascular research 2026 Feb 14;121(18):2892-2908
Cardiovascular research 2026 Feb 14;121(18):2892-2908
An immunomodulatory hydrogel featuring antibacterial and ROS-scavenging functions for enhanced burn wound healing.
Zhao XS, Zhang LP, Wang G, Yang QY, Cheng XJ, Wu CY, Wu D, Dong CB, Yang YT, Wang YF, Cai XJ, Zhu NW
Journal of nanobiotechnology 2026 Feb 13;24(1)
Journal of nanobiotechnology 2026 Feb 13;24(1)
Metamorphosing macrophages promote placental fibrosis by upregulating the transcription factor STAT5A.
Chen A, Huang X, Liao E, Shao Y
Journal of translational medicine 2026 Feb 13;24(1)
Journal of translational medicine 2026 Feb 13;24(1)
Cadmium exposure induces renal fibrosis by inhibiting hsa_circ_0075684/miR-363-3p/KLF4 signaling pathway.
Zhou J, Huang Y, Li G, Zhao Z, Deng Y, Xian S, Hu Y, Yi M, Liu L
Scientific reports 2026 Feb 13;16(1)
Scientific reports 2026 Feb 13;16(1)
Gingerenone A ameliorates airway inflammation and remodeling in asthma by modulating the TLR4/MyD88/NF-κB pathway.
Zhu Y, Chen L, Lin J, Chen M, Wu W, Chen Y, Xuan L
Journal of ethnopharmacology 2026 Feb 10;356:120656
Journal of ethnopharmacology 2026 Feb 10;356:120656
Identification and validation of the protective gene BCAT2 related to amino acid metabolism in idiopathic pulmonary fibrosis.
Zhu H, Chen M, Li Q, Cui S, Jiang C, Ye X, Hou S, Zhang J, Huang X, Cao M
Clinical and experimental medicine 2026 Feb 10;26(1):145
Clinical and experimental medicine 2026 Feb 10;26(1):145
Integration of Multi-Omics and Machine Learning Identifies TGFB1 and SERPINE1 as Biomarkers of Vascular Smooth Muscle Cell Senescence in Intracranial Aneurysms.
Qiu H, Chen K, Chen Y, Yu Y, Ma X, Yuan Z, Li M, Zhuang J, Zhang M, Su W, Wang Y, Wang D, Zhong W
Translational stroke research 2026 Feb 10;17(1):24
Translational stroke research 2026 Feb 10;17(1):24
Structural characterization and anti-hepatic fibrosis effects of a novel polysaccharide from Astragalus complanatus seeds.
Zhu ZF, Wang SY, Liu XF, Liu N, Dong DC, Qi YC, Li N, Wang N, Tan J, Jia C, Cai RQ, Li XQ, Cao W
Carbohydrate polymers 2026 Feb 1;373:124661
Carbohydrate polymers 2026 Feb 1;373:124661
Melittin-loaded solid lipid nanoparticles inhibit pulmonary fibrosis via the NOVA2-TGF-β/Smads signaling pathway.
Yuan X, Zhang T, Liu Z, Zhang S, Hang Y, Huang J, Huang W, Shen Y, Zhang X, Qian Y, Li L
International immunopharmacology 2026 Feb 1;170:116050
International immunopharmacology 2026 Feb 1;170:116050
Phosphoglucose isomerase directs the inflammatory response, calcium influx and fibroblast migration in keloids.
Lu YY, Lu CC, Wang WT, Wu CH
Future science OA 2026 Dec;12(1):2615968
Future science OA 2026 Dec;12(1):2615968
Targeting VEGFR2 inhibition within a spatially-confined conduit promotes nerve self-resolution and alleviates mechanical allodynia.
Luo X, Nagayasu T, Zhang Y, He Z, Yang J, Li C, Duan G, Zong Q, Liu Y, Yang K, Mao K, Ma P, Li Z, Zhao Y, Kim K, Zhang J, Wang Z, Luo Y, Lu J, Tong S, Yu JK, Zhao Z, Cao Z, Yang S, Pan Y, Wang X
Bioactive materials 2026 Aug;62:47-63
Bioactive materials 2026 Aug;62:47-63
Fosb promotes ferroptosis in vascular smooth muscle cells via the NF-κB pathway to exacerbate abdominal aortic aneurysm progression.
Li X, Wang Q, Zhang J, Zhao W, Zheng X
Cellular signalling 2026 Aug;144:112544
Cellular signalling 2026 Aug;144:112544
The pro-cancer and immunosuppressive activity of macrophage-transformed cancer-associated fibroblasts in oral squamous cell carcinoma.
Tian H, Zhao S, Nie F, Yin Q, Wang S, Liu J, Ju J, Yang P, Yang C
Journal of advanced research 2026 Apr;82:521-534
Journal of advanced research 2026 Apr;82:521-534
Mechanism of Cancer-Associated Fibroblasts-Derived NEAT1 Promoting Pancreatic Cancer Cell Stemness via the miR-101-3p/KDM3A Axis.
Li J, Zhou Y, Xu D
Journal of biochemical and molecular toxicology 2026 Apr;40(4):e70817
Journal of biochemical and molecular toxicology 2026 Apr;40(4):e70817
Hypoxia Imaging in Hepatic Fibrosis: A Preliminary Application of CAIX-Targeted MRI Probe in Rats.
Duan X, Xiao L, Zhao H, Gao Y, Wang L, Yu H, Zhou X, Shi X, Li Z
NMR in biomedicine 2026 Apr;39(4):e70249
NMR in biomedicine 2026 Apr;39(4):e70249
Spatiotemporal piezoelectric microspheres for wireless endometrial repair with improved pregnancy outcomes.
Zhao R, Ni S, Tao X, Liu Y, Yang N, Cheng C, Zhu Y, Yang M
Materials today. Bio 2026 Apr;37:102915
Materials today. Bio 2026 Apr;37:102915
Injectable Zn(2+)-Driven carrier-free hydrogel via self-assembly of natural small molecules for liver fibrosis therapy through concurrent autophagy activation and ferroptosis inhibition.
Zhu C, Jia S, Wang J, Gao F, Lin Y, Nie A, Guo Z, Zhou Z, Xu B, Lei H
Materials today. Bio 2026 Apr;37:102828
Materials today. Bio 2026 Apr;37:102828
An inducible and podocyte-specific diphtheria toxin receptor knock-in mouse model for studying glomerular injury and chronic kidney disease progression.
Watanabe M, Kakutani M, Nakano K, Okamura T, Sasaki N
The FEBS journal 2026 Apr;293(8):2291-2313
The FEBS journal 2026 Apr;293(8):2291-2313
Biomimetic 3D-printed bilayered scaffold with stem cell delivery for rabbit vaginal regeneration.
Zhang X, Zheng J, Xu X, Guo K, Yuan H, Shi W, Li Z, Ma Y, Feng L, Zhang J, Huang X
Biomaterials advances 2026 Apr;181:214626
Biomaterials advances 2026 Apr;181:214626
Targeting PFKFB3-dependent endothelial-mesenchymal transition by luteolin attenuates doxorubicin-induced cardiotoxicity.
Zhong X, Xia Y, Li N, Zhou M, Xie H, Shi T, Yang X, Wang Q, Wang Y, Guo D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157945
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157945
Inhibitory effect of Anwulignan on the IL-36R/TLR9 signaling pathway: potential therapeutic role in hepatic fibrosis.
Shang Y, Peng YG, Wang Y, Huo XK, Zhang HL, Hao TN, Ma XC
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157931
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157931
Flexible Bioactive Glass-Fiber-Reinforced Recombinant Collagen Sponge for Versatile Hemostasis, Antibacterial Protection, and Functional Skin Regeneration.
Fan Z, Li M, Cai K, Xie Z, Lu B, Zhang M, Zhang Y, Wang J, Gu C, Zheng K, Chen T
Advanced healthcare materials 2026 Apr;15(16):e04908
Advanced healthcare materials 2026 Apr;15(16):e04908
Protective Effects of Agrimonia pilosa Ledeb. In Myocardial Fibrosis: Inhibition of Mitophagy Mediated by the FOXO Signaling Pathway.
Chen J, Wei Z, An J, Li D, Gu Y, Zhang Y, Zhang M
Food science & nutrition 2026 Apr;14(4):e71778
Food science & nutrition 2026 Apr;14(4):e71778
The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis.
Guo S, Wang Y, Lu B, Zhang Y, Frazer DM, Zhou B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(20):e16446
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(20):e16446
SIRT1-regulated mitophagy mitigates lipotoxicity-induced ferroptosis in diabetic kidney disease.
Jian Y, Zeng Y, Wang Z, Zhou X, Zhang H, Liang D, Yan R
Apoptosis : an international journal on programmed cell death 2026 Apr 7;31(4)
Apoptosis : an international journal on programmed cell death 2026 Apr 7;31(4)
UCHL3 Promotes Triple-Negative Breast Cancer Metastatic Potential Through Enhancing Cell Migration and Invasion.
Xu Q, Yang W, Li C, Yang M, Zhu X, Wang W, Lin Y, Gan Z, He T, Wu X, Li X
Applied biochemistry and biotechnology 2026 Apr 7;
Applied biochemistry and biotechnology 2026 Apr 7;
Mechanisms of Mechanical Stress-Induced Vascular Remodeling via the Lactate-PKM2 Axis and Implications for Microgravity Adaptation.
Li N, Liu L, Wang D, Wang J, Tie Y, Li X, Li J, Gao Y, Yang C, Wang Y
International journal of molecular sciences 2026 Apr 5;27(7)
International journal of molecular sciences 2026 Apr 5;27(7)
Therapeutic effects of IL-33/ST-2 pathway inhibition combined with albendazole on hepatic fibrosis and immune regulation in alveolar echinococcosis: in vivo and in vitro evidence.
Cheng SL, Ma XM, Wu BJ, Yang YX, Fan HN
Parasites & vectors 2026 Apr 3;19(1)
Parasites & vectors 2026 Apr 3;19(1)
Emerging Alternaria Toxins Drive LX-2 Cells Transdifferentiation into Myofibroblasts for Liver Fibrosis and CotA Detoxification.
Lin H, Jia B, Chang B, Sun F, Tan Y, Tian Y, Fan Y, Liang J, Wu A
Journal of agricultural and food chemistry 2026 Apr 29;74(16):13162-13178
Journal of agricultural and food chemistry 2026 Apr 29;74(16):13162-13178
USP10 from Human Umbilical Cord Mesenchymal Stem Cells-Derived Extracellular Vesicles Mediates SCL7A11 Deubiquitination in Epithelial Cells: A Key to Anti-ferroptosis and Anti-fibrosis in Pulmonary Fibrosis.
Zhuo Y, Lin L, Lin N, Lai F
Lung 2026 Apr 29;204(1)
Lung 2026 Apr 29;204(1)
Subamnex Ameliorates Hypoxia-Induced Pulmonary Arterial Hypertension through Modulation of the STAT3/p-STAT3 Pathway.
Ge RX, Shi JZ, Guo BH, Zhang MJ, Zeng M, An XR, Ye JS, Cheng G, Fan X, Wang MW, Zhou YF, Li X, Pang XB, Xie XM, Zhang HD, Zhao LL, He YY, Kou JJ, Ma J, Yan Y
Journal of medicinal chemistry 2026 Apr 23;69(8):8790-8806
Journal of medicinal chemistry 2026 Apr 23;69(8):8790-8806
DECR1 degradation by ursolic acid alleviates vascular calcification through inhibition of NF-κB/NLRP3 signaling pathway.
Yang H, Chen A, Ye Y, Zhou X, Li Y, Wen X, Du Z, Lan Z, Yan J
Free radical biology & medicine 2026 Apr 23;251:387-404
Free radical biology & medicine 2026 Apr 23;251:387-404
Knockdown of METTL3 ameliorated myofibroblast activities in oral submucous fibrosis through upregulating DKK3.
Peng J, Guo S, Zhang P
Tissue & cell 2026 Apr 20;102:103544
Tissue & cell 2026 Apr 20;102:103544
TKT inhibition attenuates cardiac fibrosis in myocardial infarction through deactivating AKT signaling pathway.
Zhang X, Qin J, Lv F, Kang X, He L
Journal of translational medicine 2026 Apr 2;24(1)
Journal of translational medicine 2026 Apr 2;24(1)
Triggering Receptor Expressed on Myeloid Cells-2 Regulates Innate Lymphoid Cell Levels in Bleomycin-Induced Pulmonary Fibrosis.
Shen HC, Chen NJ, Sun CY, Yu WK, Su VY, Yang WL, Chen WC, Yang KY
The Kaohsiung journal of medical sciences 2026 Apr 2;:e70209
The Kaohsiung journal of medical sciences 2026 Apr 2;:e70209
Targeting keratin 6 A overcomes gemcitabine resistance by restoring equilibrative nucleoside transporter 1 and TAM-mediated metabolic compensation in pancreatic cancer.
Zhang J, Wang X, Zeng S, Tang B, Yang X, Xie S, Sun H, Wang R, Xia R, Li J, Wang H, Shi Z, Gu J, Wei D
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2026 Apr 17;87:101404
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2026 Apr 17;87:101404
Mammary organoid-based depot for post-surgical chemotherapy and gland regeneration.
Wang S, Yang Y, Wang Y, Han J, Hu T, Zhao S, Liu F, Yu X, Liang T, Zhang Y, Hu H, Yu J, Gu Z
Nature biomedical engineering 2026 Apr 17;
Nature biomedical engineering 2026 Apr 17;
Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates diabetic nephropathy via suppressing SLC7A11-mediated ferroptosis.
Yu L, Zhai Z, Wang Y, Wang L, Li Q, Guo Y, Liang Y, Tang L
International immunopharmacology 2026 Apr 15;175:116448
International immunopharmacology 2026 Apr 15;175:116448
IL-5 promotes airway remodeling in asthma by mediating epithelial-mesenchymal transition via the AKT/NLRP3 pathway.
Zhao L, Lin Y, Dou M, Su H, Han L, Wu J, Lu Y, Bao W, Zhang M
International immunopharmacology 2026 Apr 15;175:116422
International immunopharmacology 2026 Apr 15;175:116422
Vericiguat improves CKD-related vascular calcification through the NO/cGMP/PKG pathway.
Li C, Li J, Yang C, Zhu Z, Zhang Y, Xiang Y
International immunopharmacology 2026 Apr 15;175:116413
International immunopharmacology 2026 Apr 15;175:116413
Cardiac reprogramming via transient overexpression of P-glycoprotein alleviates doxorubicin-induced cardiotoxicity in mice and pigs.
Zhang Y, Li W, Xiao Y, Luo L, Ai J, Mo S, Li L, Deng J, Wang X, Li Q, Zeng Y, Liu H, Wang F, Li Z
Nature communications 2026 Apr 15;
Nature communications 2026 Apr 15;
Dissolvable Microneedle Arrays Loaded with SCH772984 Targeting the MAPK/ERK Pathway to Inhibit Abnormal Vascular Proliferation in Hypertrophic Scars.
Yang S, Yang J, Li H, Ma K, Zhang Z, Yang S, Fu X
ACS biomaterials science & engineering 2026 Apr 13;12(4):2354-2369
ACS biomaterials science & engineering 2026 Apr 13;12(4):2354-2369
Beryllium Sulfate-Induced Cellular Senescence via the IL-6/STAT3 Pathway to Promote Pulmonary Fibrosis.
Lu Y, Li Y, Tong Y, Huang L, Zhang Z
Journal of applied toxicology : JAT 2026 Apr 13;
Journal of applied toxicology : JAT 2026 Apr 13;
VHL-recruiting PROTAC attenuates AKI-CKD transition via simultaneous degradation of Smad3 and stabilization of HIF-2α.
Ruan Y, Wang D, Xu Y, Yang J, Chen Y, Fan J, Tang SCW, Chen W, Wang X
Cell death & disease 2026 Apr 10;17(1)
Cell death & disease 2026 Apr 10;17(1)
Integrative metabolomics and lipidomics reveal Jian-Pi-Yi-Shen formula improves adenine-induced CKD rats by regulating intrarenal glycolipid metabolism.
Liu X, Li H, Xu Y, Peng Y, Wu S, Ye X, Yang Y, Lu J
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2026 Apr 1;1273:124957
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2026 Apr 1;1273:124957
Increased PRSS56 expression is a causal factor and therapeutic target for human axial high myopia.
Wu B, Zeng W, Tang K, Xiong J, Mo X, Fu Q, Fu D, Chu R, Zhao G, Lu L, Wang Z, Wu L, Yu Z, Zhou X, Wang H
Cell research 2026 Apr 1;
Cell research 2026 Apr 1;
Store-operated Ca(2+) entry contributes to the ASM phenotype transition in asthma.
Ni H, Li T, Chen J, Wei Y, Xia M, Wang Q
Experimental lung research 2025;51(1):23-37
Experimental lung research 2025;51(1):23-37
HE4 Might Participate in Extracellular Matrix Remodeling in Ovarian Cancer via Activation of Fibroblasts.
Liu Y, Liu B, Gao H, Wang J, Duan J, Huang X, Liu Y, Huang Y, Liao W, Li R, Linghu H
Oncology research 2025;34(1):18
Oncology research 2025;34(1):18
Targeting Smad3 Phosphorylation Attenuates Anastomotic Intimal Hyperplasia and Perigraft Fibrosis in Decellularized Tissue-Engineered Vascular Grafts.
Lu P, Wang T, Liao S, He Z, Cheng S, Wang T, Cheng Z, An Y, Zhou S, Wang M, Zhang Q, Shu C
Biomaterials research 2025;29:0241
Biomaterials research 2025;29:0241
Perfluorocarbon Nanoparticles Loaded with Oxygen Alleviate Acute Kidney Injury via Ameliorating Renal Oxygenation Level.
Li D, Ju Y, Ye Q, Chang Y, An C, Liu B, Lu L, Wu J, Zhao X
Biomaterials research 2025;29:0181
Biomaterials research 2025;29:0181
Integrated transcriptome and proteome analysis identifies keratins as key regulators of corneal scarring in a murine model.
Zhou T, Cai Y, Fang F, Cai X, Fu Y
Computational and structural biotechnology journal 2025;27:2264-2274
Computational and structural biotechnology journal 2025;27:2264-2274
Mechanisms of AGE-induced VSMC phenotypic switching and macrophage modulation in human abdominal aortic aneurysms.
Ma X, Xu J, Sun H, Liu J, Xia S, Zhang H, Cui C, Song C
Experimental biology and medicine (Maywood, N.J.) 2025;250:10527
Experimental biology and medicine (Maywood, N.J.) 2025;250:10527
GDF10 attenuates MASH progression by restoring quiescent hepatic stellate cells via competitive inhibition of TGF-β/SMAD2 signaling.
Peng Y, Lei H, Zhao J, Wang H, Luo Z, Wang D, Shi S, Wang T, Li J, Pang Z, Wang B, Xiong X
International journal of biological sciences 2025;21(15):6997-7012
International journal of biological sciences 2025;21(15):6997-7012
Mechanical stretch-induced IGF2 overexpression in epidermal keratinocytes promotes hypertrophic scar formation through the IGF1R/p-c-Jun axis.
Zhu Y, Chen L, Song B, Cui Z, Chen G, Dou W, Jiao Y, Dang J, Yang Q, Yu Z, Song B
International journal of biological sciences 2025;21(1):109-127
International journal of biological sciences 2025;21(1):109-127
Expression Profile of Urinary Exosomal miRNAs in Patients With Diabetic Kidney Disease and Their Association With Kidney Damage.
Li J, Han L, Wang T, Yang L, Zhou H
International journal of endocrinology 2025;2025:9927320
International journal of endocrinology 2025;2025:9927320
Targeting interferon-stimulated gene of 20 kDa protein (Isg20) inhibits ribosome biogenesis to ameliorate the progression of renal fibrosis.
Liu X, Wang H, Wang K, Liu Y
PloS one 2025;20(7):e0322639
PloS one 2025;20(7):e0322639
Inhibition of PHB1/PHB2 suppresses atherosclerotic plaque formation by interrupting PI3K/AKT/mTOR signaling.
Li M, Hu X, Hu X, Gao F, Cui Y, Wei X, Qin Y, An X, Zhao Y, Gao Y
PloS one 2025;20(4):e0320509
PloS one 2025;20(4):e0320509
Plasma-activated media inhibits epithelial-mesenchymal transition and ameliorates intestinal fibrosis through the PPARγ/TGF-β1/SMAD3 pathway.
You Y, Shen Y, Yang Y, Wei X, Zhou Y, Tan F, Deng L, Du H, Wang S, Wang C, Huang Y
PloS one 2025;20(10):e0335225
PloS one 2025;20(10):e0335225
NIR-II Imaging Guided Accurate Identification of Paraspinal Muscle Degeneration Through Targeting the Lysosomal Membrane Protein Sidt2.
Piao G, Fan L, Zhang Y, Jiang W, Guo X, Liu R, Wang Q, Jia S, Liang J, Li Y
International journal of nanomedicine 2025;20:7743-7762
International journal of nanomedicine 2025;20:7743-7762
TFR1 as a Biomarker of Pulmonary Fibrosis Development in COPD Patients.
Wu Y, Jiang Y, Xiao B, Xie L, Zhou N, Zeng A, Liu C
International journal of chronic obstructive pulmonary disease 2025;20:2715-2725
International journal of chronic obstructive pulmonary disease 2025;20:2715-2725
Enhanced Antitumor Efficacy and Reduced Toxicity in Colorectal Cancer Using a Novel Multifunctional Rg3- Targeting Nanosystem Encapsulated with Oxaliplatin and Calcium Peroxide.
Xie Y, Zhu M, Bao H, Chen K, Wang S, Dai J, Chen H, Li H, Song Q, Wang X, Yu L, Pei J
International journal of nanomedicine 2025;20:1021-1046
International journal of nanomedicine 2025;20:1021-1046
Liu Wei Di Huang Decoction Alleviates Renal Fibrosis by Inhibiting Endothelial Mesenchymal Transitions via Upregulating Sirt1 Expression and Inhibiting the Wnt/β-Catenin Signaling Pathway.
Wang H, Chen SS, Zhang YX, Gao HB, Meng B, Wu WY, Tang Q
Drug design, development and therapy 2025;19:6587-6603
Drug design, development and therapy 2025;19:6587-6603
ShenQi ShenKang Granule Alleviates Chronic Kidney Disease by Inhibiting the PI3K/AKT/mTOR Pathway and Restoring Autophagy Flux and Mitochondrial Integrity.
Xia C, Zhang J, Chen H, Zhou S, Jiang W, Zheng H, Lin Z, Tan Q, Sun W
Drug design, development and therapy 2025;19:3925-3947
Drug design, development and therapy 2025;19:3925-3947
Mechanism of the Traditional Chinese Medicine Simiao Biejia Decoction Improves the Diabetes Mellitus-Induced Erectile Dysfunction in Rats.
Liu Y, Sun D, Xing D, Rui Y, Jin Y, Wang P, Cai B, Li C, Gao C, Cui Y, Jin B
Drug design, development and therapy 2025;19:2609-2628
Drug design, development and therapy 2025;19:2609-2628
PLK1 Mediates the Proliferation and Contraction of Airway Smooth Muscle Cells and Has a Role in T2-High Asthma with Neutrophilic Inflammation Model.
Pan Y, Xue Y, Fei X, Zhao L, Han L, Su H, Lin Y, Zhou Y, Zhang Y, Xie G, Kong D, Bao W, Zhang M
Journal of inflammation research 2025;18:4381-4394
Journal of inflammation research 2025;18:4381-4394
Rapamycin and Chloroquine Modulate Insulin Resistance and Hepatic Steatosis in a High-Fat/High-Cholesterol Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Mouse Model.
Liu Q, Du Q, Yuan X, Zhang T, Li J, Xu J, Xie R
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:4059-4072
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:4059-4072
SIRT1 Enhancement is Required for the Induction of Anti-Inflammatory Effect of Micheliolide in Carbon Tetrachloride Induced Liver Fibrosis in Mice.
Jin C, Jiang A, Chang J, Hu Y, Wang Y, Zhao R, Shi J, Wu H, Han Z, Liu Z
Journal of inflammation research 2025;18:16231-16245
Journal of inflammation research 2025;18:16231-16245
Cannabidiol Alleviates Intestinal Fibrosis in Mice with Ulcerative Colitis by Regulating Transforming Growth Factor Signaling Pathway.
Wang Y, Ji X, Wang X, Sun M, Li C, Wu D
Journal of inflammation research 2025;18:1-15
Journal of inflammation research 2025;18:1-15
Aldose Reductase Mediated Mitophagy Promotes Epithelial-Mesenchymal Transition of Hepatocytes.
Yan J, Zhao W, Wang H, Zhou L, Li X, Wang G
Hepatic medicine : evidence and research 2025;17:141-159
Hepatic medicine : evidence and research 2025;17:141-159
Multi-Omics Analysis Reveals the transforming growth factor-β Signaling-Driven Multicellular Interactions with Prognostic Relevance in Cervical Cancer Progression.
Wang Y, Cao G, Zeng H, Zhi Y, Xu M, Wang Y, Liu M, Ruan Y, Tse KY, Zhang Q, Gao J, Han Z, Li F
Journal of Cancer 2025;16(9):2857-2876
Journal of Cancer 2025;16(9):2857-2876
Quercetin ameliorates renal injury in hyperuricemic rats via modulating ER stress pathways.
Liu H, Yang Q, Wang S, Wang T, Pan L, Wang X, Chi Y, Jin Z
Frontiers in pharmacology 2025;16:1660599
Frontiers in pharmacology 2025;16:1660599
Targeted ferroptosis of myofibroblasts by tubeimoside I attenuates hypertrophic scar formation.
Wang J, Wang C, Jia Y, Chen F, Wang Y, Du J
Frontiers in pharmacology 2025;16:1654108
Frontiers in pharmacology 2025;16:1654108
Targeting macrophage-myofibroblast transition with Caulis spatholobi to attenuate renal interstitial fibrosis: integrated UHPLC-Q-Exactive Orbitrap-MS, network pharmacology, and experimental validation.
Song Z, Zhang Y, Yang C, Ren K, Cheng Y, Zhang Z, Ren T, Chen Y, Li X, Lin Y
Frontiers in pharmacology 2025;16:1649902
Frontiers in pharmacology 2025;16:1649902
Identify GDPD3 as a key regulator of epithelial-mesenchymal transition and prostate adenocarcinoma progression via the LPA/LPAR1/AKT axis: transcriptomic and experimental study.
Hao L, Chen X, He T, Wu T, Wen Z, Ji Z, Zheng X, Zheng Q, Zhou Q, He C, Long Q, Sun D
Frontiers in immunology 2025;16:1637325
Frontiers in immunology 2025;16:1637325
Identifying potential drugs for treating Cardiovascular-kidney metabolic syndrome via reverse network pharmacology.
Wen S, Fu A, Liu F, You Y, Li L, Xiao W, Zhong H, Hong X, Zhong X, Hu Y, Liu Z
Frontiers in pharmacology 2025;16:1627236
Frontiers in pharmacology 2025;16:1627236
Loss of p21 does not protect against premature ovarian insufficiency caused by alkylating agents.
Lu X, Han Y, Song J, Wan Q, Liu P, Chen L, Wang Y, Xue P, Dai X
Frontiers in endocrinology 2025;16:1616965
Frontiers in endocrinology 2025;16:1616965
Quercetin ameliorates epithelial-mesenchymal transition and inflammation by targeting FSTL1 and modulating the NF-κB pathway in pulmonary fibrosis.
Lan Y, Dong C, Wu M, Yuan R, Yang K, Yang Z, Chen Y, Zhang J, Qi B, Lu X
Frontiers in pharmacology 2025;16:1594757
Frontiers in pharmacology 2025;16:1594757
Lactobacillus rhamnosus GG attenuates MASLD/MASH progression by modulating gut microbiota and metabolic pathways.
Wang SL, Liang S, Li SY, Fu JW, Wang ZY, Zhu DQ, Chen N
Frontiers in microbiology 2025;16:1586678
Frontiers in microbiology 2025;16:1586678
Programmed cell death-related prognostic genes mediate dysregulation of the immune microenvironment in triple-negative breast cancer.
Ma X, Shan H, Chen Z, Shao R, Han N
Frontiers in immunology 2025;16:1563630
Frontiers in immunology 2025;16:1563630
Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation.
Yan Y, Fang M, Zhao C, Lin X, Tong C, Xiang C, Ran Y, Wang X, Li S, Chen G, Fu L
Frontiers in pharmacology 2025;16:1542296
Frontiers in pharmacology 2025;16:1542296
Serum chemokines combined with multi-modal imaging to evaluate atherosclerotic plaque stability in patients undergoing carotid endarterectomy.
Yuan X, Guo L, Chen H, Gao Y, Guo F, Huang J, Jiang C, Wang Z
Frontiers in neurology 2025;16:1537161
Frontiers in neurology 2025;16:1537161
Role of integrin α4 in the inhibition of fibrosis in activated hepatic stellate cells by Periplaneta americana extract.
Fang Y, Liu Y, Li D, Miu Y, Chen K, Zhou J, Xie L, Chen X, Wu J, Zhu Y, Lv L, Li W
Frontiers in pharmacology 2025;16:1517491
Frontiers in pharmacology 2025;16:1517491
MgSO(4) as a novel hypothermia infusion solution promotes ischemic stroke recovery through Ca(2+) regulation of neurovascular units.
Zhang Y, Jiang M, Wei M, Wu C, Huang Y, Song B, Xu Y, Zhang H, Shen Y, Wu D, Zheng Y, Li M, Ji X
Theranostics 2025;15(5):1896-1913
Theranostics 2025;15(5):1896-1913
A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY.
Zhang Z, Chen M, Xu Y, Wang Z, Liu Z, He C, Zhang F, Feng X, Ni X, Chen Y, Wang J, Liang X, Xie Z, Li J, Banach M, Pelisek J, Huo Y, Hu Y, Evans PC, Wang L, Tian XY, Xiao J, Shang Y, Zheng Y, Xian X, Weng J, Xu S
Theranostics 2025;15(10):4325-4344
Theranostics 2025;15(10):4325-4344
Ivermectin attenuates Schistosoma japonicum-induced liver fibrosis and is associated with downregulation of YAP signaling.
Xuan M, Zhang P, Guo J, Guan F, Lu S, Liu W
Frontiers in cellular and infection microbiology 2025;15:1678067
Frontiers in cellular and infection microbiology 2025;15:1678067
The Effects of M2 Macrophages-Derived Exosomes on Urethral Fibrosis and Stricture in Scar Formation.
Ren X, Wang Z, Wang J, Li X, Wei H, Liu C, Liu S, Zhu Y, Feng C, Yin Y, Tian Y, Wu M, Zeng X
ImmunoTargets and therapy 2025;14:151-173
ImmunoTargets and therapy 2025;14:151-173
IGF1R promotes radiation-induced HSCs activation by regulating DNA-PKcs-mediated DNA damage repair.
Lin J, Zhao G, Feng J, Sun C, Liu C, Li J, Shen Y, Cheng Y
Frontiers in cell and developmental biology 2025;13:1678654
Frontiers in cell and developmental biology 2025;13:1678654
Deciphering the tumor ecosystem dynamics undergoing immunochemotherapy therapy across multiple cancer types unveils the immunosuppressive role of S100A4 in fibroblasts by promoting PD-L1 expression in tumor cells.
Yang B, Chen R, Zu M, Yao J, Ren H, Lin Y, Zhang B, Ji T, Liu Y
Frontiers in cell and developmental biology 2025;13:1613296
Frontiers in cell and developmental biology 2025;13:1613296
Saliva-derived exosomes regulate fibroblast metabolic reprogramming in skin wound healing.
Song S, Xiang R, Chen S, Wu J, Chen W, Li X
Frontiers in cell and developmental biology 2025;13:1606716
Frontiers in cell and developmental biology 2025;13:1606716
Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice.
Cheng W, Wang C, Ma M, Zhou Y
Frontiers in cell and developmental biology 2025;13:1529901
Frontiers in cell and developmental biology 2025;13:1529901
Injury and cyclic stretch induce vein graft failure: effective treatment with zinc oxide-loaded electrospun polycaprolactone external stent.
Ma T, Tian W, Zhu F, Qi Y, Huang K
Regenerative biomaterials 2025;12:rbaf119
Regenerative biomaterials 2025;12:rbaf119
Rhodiola rosea-derived exosome-like nanovesicles inhibit vascular endothelial pyroptosis in the treatment of limb skeletal muscle ischemic injury through the TXNIP/NLNP3 pathway.
Liu D, Zhang Z, Wang Y, Liang X, Chang Y, Wang C, Guo Y, Zhang S, Zhou J, Zhang M, Shen H, Zhang X, Gao W
Regenerative biomaterials 2025;12:rbaf113
Regenerative biomaterials 2025;12:rbaf113
Glutamate enhances the production of inflammatory cytokines IL-6 and IL-11, as well as chemokines CXCL2, CXCL3, and CXCL8 in keloid fibroblasts.
Chen Y, Xu Y, Zhang J, Feng C, Chen J, Song Y, Pan J, Zhu J, Cheng H
Frontiers in molecular biosciences 2025;12:1720876
Frontiers in molecular biosciences 2025;12:1720876
The endogenous glutamatergic transmitter system promotes collagen synthesis in cardiac fibroblasts under hypoxia.
Wang R, Yuan X, Xie T, Zhao X, Li J, Zhang X, Lv C
Frontiers in cardiovascular medicine 2025;12:1638650
Frontiers in cardiovascular medicine 2025;12:1638650
Ascorbic acid deficiency promotes metabolic remodeling and pulmonary fibrosis that leads to respiratory failure in Sod1 and Akr1a double-knockout mice.
Osaki T, Homma T, Soma Y, Miyata S, Matsuda Y, Fujii J
Redox biology 2025 Sep;85:103749
Redox biology 2025 Sep;85:103749
The Paeonol of Total Glucosides of White Peony Regulates the Differentiation of CD4+Treg Cells through the EP300/Foxp3 Axis to Relieve Pulmonary Fibrosis in Mice.
Yan M, Wang Q, Yang H, Liu D, Liang W, Chen H
Cell biochemistry and biophysics 2025 Sep;83(3):3959-3970
Cell biochemistry and biophysics 2025 Sep;83(3):3959-3970
Suyin Detoxification Prescription Regulates the Klotho and ERK/NF-κB Signaling Pathways to Alleviate Renal Injury.
Shu L, Quan L, Wang Y, Chen Y, Yong C, Tian F, Gao K, Zhou E
Cell biochemistry and biophysics 2025 Sep;83(3):3137-3152
Cell biochemistry and biophysics 2025 Sep;83(3):3137-3152
Diosmetin alleviates osteoarthritis through modulating the polarization of macrophages by inhibiting the PI3K/Akt signaling pathway.
Ren S, Zeng W, Du Z, Dai J, Li X, Wang H, Liu Y, Li R, Liu J
Journal of natural medicines 2025 Sep;79(5):1030-1043
Journal of natural medicines 2025 Sep;79(5):1030-1043
Sustained oxygen-releasing hydrogel implants enhance flap regeneration by promoting mitochondrial biogenesis under mild hypoxia.
Jeon S, Jeong SH, Lee MH, Seo JW, Kim DS, Bassous NJ, Lozano Soto JA, Choi C, Gonzalez ML, Nolasco Díaz EB, Kim H, Shin SR, Park JU
Bioactive materials 2025 Sep;51:559-574
Bioactive materials 2025 Sep;51:559-574
Dl-3-n-butylphthalide attenuates acute myocardial infarction by inhibiting the binding of Nrf2/Keap1.
Yan Y, Huang Z, Cheng L, Zhao S, Gao H, Chen K, Huang F, Mou L, Chen G, Fu L, Xu G
Toxicology and applied pharmacology 2025 Sep;502:117424
Toxicology and applied pharmacology 2025 Sep;502:117424
miR-210-3p Ameliorates Metabolic Dysfunction-Associated Steatohepatitis-Related Fibrosis by Targeting ISCU and Induces Ferroptosis.
Dai Z, Sun Z, Chen Q, Li Y, Sun Y, Jiao M, Yin X, Liu R, Liang H, Zhu C
Liver international : official journal of the International Association for the Study of the Liver 2025 Sep;45(9):e70282
Liver international : official journal of the International Association for the Study of the Liver 2025 Sep;45(9):e70282
METTL3 Mediates Wnt/β-Catenin Pathway in Epithelial-Mesenchymal Transition of 16HBE Cells Induced by Beryllium Sulphate.
Yan C, Li G, Huang L, Zhang Z
Journal of applied toxicology : JAT 2025 Sep;45(9):1787-1797
Journal of applied toxicology : JAT 2025 Sep;45(9):1787-1797
Leukemia Inhibitory Factor via JAK-STAT Signaling Drives Beryllium Sulfate-Induced Epithelial-Mesenchymal Transition in 16HBE Cells.
Li Y, Sun Z, Tong Y, Yan C, Huang L, Zhang Z
Journal of applied toxicology : JAT 2025 Sep;45(9):1720-1729
Journal of applied toxicology : JAT 2025 Sep;45(9):1720-1729
Recombinant chromosome 6 open reading frame 120 protein promotes angiogenesis and endothelial‑to‑mesenchymal transition in human umbilical vein endothelial cells via the PI3K/Akt signaling pathway.
Lin Y, Wang X, Li Y, Cui X, Zhu N, Li X
Molecular medicine reports 2025 Sep;32(3)
Molecular medicine reports 2025 Sep;32(3)
Novel partial common bile duct ligation procedure in rats with reduced mortality and delayed onset of cirrhosis.
Xia W, Yao H, Mu T, Liu H, Chen J, Feng S, Wen S
Experimental and therapeutic medicine 2025 Sep;30(3):167
Experimental and therapeutic medicine 2025 Sep;30(3):167
METTL3 Silencing Suppresses Cardiac Fibrosis Post Myocardial Infarction via m6A Modification of SMOC2.
He Y, Pan X, Liu Z, Zuo P, Sheng Z, Hao C, Tao Z, Chen Z, Song J, Ma G, Ling S
Journal of cellular and molecular medicine 2025 Sep;29(17):e70829
Journal of cellular and molecular medicine 2025 Sep;29(17):e70829
KLF3 aggravates renal fibrosis in chronic kidney disease through transcriptional activation of DDAH2.
Zhang J, Yang X, Zhao X, Luo G, Jiang H
Biochemical pharmacology 2025 Sep;239:117033
Biochemical pharmacology 2025 Sep;239:117033
IFITM1 promotes proliferation, migration and macrophage-like transdifferentiation of vascular smooth muscle cells via c-Src/MAPK/GATA2/E2F2 pathway in atherosclerosis.
Huang QH, Tang XY, Huang QY, Zhi SB, Zheng XQ, Gan CY, Huang MF, Pan ZF, Zhong ZX
Biochemical pharmacology 2025 Sep;239:117014
Biochemical pharmacology 2025 Sep;239:117014
Mito-tempo ameliorates tubular injury of diabetic nephropathy via inhibiting mt-dsRNA release and PKR/eIF2α pathway activation.
Duan T, Sun L, Xi Y, Li C, Zhao Q, Xu L, Yang M, Liu C, Xiao L, Deng T, Sun L
Free radical biology & medicine 2025 Sep;237:147-159
Free radical biology & medicine 2025 Sep;237:147-159
Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients and Mice with Wilson Disease.
Wang Z, Xu Q, Wang M, Xiao Q, Xu Y, Wang X, Shi Y, Yang R, Fan JG
The American journal of pathology 2025 Sep;195(9):1600-1618
The American journal of pathology 2025 Sep;195(9):1600-1618
The chemokine CCL20 promotes hepatocyte cholesterol deposition during metabolic dysfunction-associated steatohepatitis by regulating OLR1 expression.
Yin M, Zhang Y, Liu S, Wang Q, Zhang Y, Min J, Yang J, Zhao Y, Zhou Z, Li X, Liu S
Metabolism: clinical and experimental 2025 Sep;170:156301
Metabolism: clinical and experimental 2025 Sep;170:156301
Shenling Tongqiao powder targets TGF-β1/Smad-Wnt/β-catenin axis to suppress epithelial-mesenchymal transition in chronic rhinosinusitis.
Liu K, Zeng H, Zhu X, Deng H, Deng W, Li S, Zhu Y, Bin J, Lu S, Wu W, Wu Q, Liao J, Hu G, Chang W, Ying Y, Wang Y, Zhu Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157065
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157065
Multi-omics analysis of the active components and mechanisms of Baojin Chenfei formula in silica-induced murine silicosis.
Wr H, Yq L, Xg L, Yf Z, Y W, P Z, Js L, Q Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156986
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156986
Cancer Cell-Secreted miR-33a Reduces Stress Granule Formation by Targeting Polyamine Metabolism in Stroma to Promote Tumourigenesis.
Hu S, Li X, Hu Q, Wang C, Hua A, Deng G, Huang W, Fu X, Zhou H, Zhang X, Li M, Wu J, Chen M, Zhao X, Li L, Li Z, Wu M, Li J, Yan W
Journal of extracellular vesicles 2025 Sep;14(9):e70153
Journal of extracellular vesicles 2025 Sep;14(9):e70153
PINK1 deficiency alleviates bleomycin-induced pulmonary fibrosis in mice.
Gu YQ, Wu J, Wang T, Yu YF, Han J, Chen YL, Hu XL, Wu M, Hu H, Zhang WP, Lu YB, Jiang B
Cellular signalling 2025 Sep;133:111868
Cellular signalling 2025 Sep;133:111868
The role of APOBEC mutagenesis in the progression and therapeutic guidance of pancreatic cancer.
Yu X, Shen G, Liu Z, Kaysar P, Shang X, Ni B, Zhang W, Zhou Y, Xie Y, Liu W
Genomics 2025 Sep;117(5):111098
Genomics 2025 Sep;117(5):111098
5-Aminolevulinic acid-mediated photodynamic therapy improves scar healing of laryngeal wounds in rats.
Li J, Lu Y, Hu H, Han X, Pan Y, Sun K, Liu K, Yu Z
Lasers in medical science 2025 Sep 9;40(1):353
Lasers in medical science 2025 Sep 9;40(1):353
Comparative analysis of commercial human primary mesangial cell, implications for experimental design.
Johansson A, Narasimhan G, Keuenhof K, Boi R, Ebefors K
BMC nephrology 2025 Sep 29;26(1):539
BMC nephrology 2025 Sep 29;26(1):539
MiR-7683-3p from M2-exosomes attenuated atherosclerosis by activating the PPARγ-LXRα-ABCG1 pathway mediated cholesterol efflux of vascular smooth muscle cell derived foam cells.
Wang S, Lv Y, Wang X, Zhang Z, Li J, Pan TI, Yung MAC, Zhang F, Zhang H, Meng J, Lian H, Wen S, Hao X, Wang P, Zhang Q, He T, Zhang Y, Wang X, Song J, Cui Y
Journal of nanobiotechnology 2025 Sep 29;23(1):618
Journal of nanobiotechnology 2025 Sep 29;23(1):618
Morphological and histopathological study of edible bird's nest on wound healing in mice.
Li M, Liu B, Yuan M, Dai X, Qiu S, Zhang X, Zheng X, Chen K, Duan C, Zhang D, Wang D, Meng X
Journal of molecular histology 2025 Sep 26;56(5):328
Journal of molecular histology 2025 Sep 26;56(5):328
Mechanism of Bao Gan Ning decoction in attenuating hepatic fibrosis via modulation of the gut microbiome and PPAR/CYP7A1-mediated bile acid metabolism.
Li M, Deng K, Zheng R, Li Y, Xiang L, Cheng J, Wang Y, Kuang S, Huang S, Lv Z
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120488
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120488
Danggui Buxue Decoction inhibits pulmonary fibrosis by alleviating TGF-β1-induced proliferation and apoptosis in EBL cells via PI3K/AKT/FOXO1 pathway.
Yang Z, Ji P, Zhang W, Li C, Wu F, Hua Y, Wei Y, Cao Y
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120384
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120384
Yishen Qufeng formula mediates ferroptosis to improve renal fibrosis in unilateral ureteral obstruction rats.
Gao J, Wei Y, Zhang W, Yu Y, Ge H, Tian F, Zhou E
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120376
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120376
Kaempferol improves mitochondrial homeostasis via mitochondrial dynamics and mitophagy in diabetic kidney disease.
Xia C, Zhang J, Chen H, Jiang W, Zhou S, Zheng H, Sun W
International immunopharmacology 2025 Sep 23;162:115121
International immunopharmacology 2025 Sep 23;162:115121
Caffeic acid mitigates restenosis post-angioplasty via oxidative stress and inflammation reduction and mitochondrial protection in vascular smooth muscle cells.
Du Y, Liu X, Yang P, Nie Z, Wang H
International immunopharmacology 2025 Sep 23;162:115103
International immunopharmacology 2025 Sep 23;162:115103
Unraveling the therapeutic mechanisms of Bufei Yiqi decoction in pulmonary fibrosis: Modulation of autophagy and glycolysis pathways.
Chen H, Zhang Z, Song Y, Hu Q, Jin D, Liu S, Zu J, Zhang L, Ke M, Chen L, Hu A
International immunopharmacology 2025 Sep 23;162:115030
International immunopharmacology 2025 Sep 23;162:115030
Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.
Ma Y, Huang J, Gong J, Li L, Zhao Y, Jin Y, Gu J, Liu H, Wang Y, Sun Y
Chinese medicine 2025 Sep 22;20(1):146
Chinese medicine 2025 Sep 22;20(1):146
Therapeutic potential of Desmodium styracifolium polysaccharide in attenuating nano-calcium oxalate induced renal injury and fibrosis.
Yu BX, Long J, Liang YP, Zhang Q, Liu Y, Zeng GH, Liu YD, Sun XY
Communications biology 2025 Sep 2;8(1):1330
Communications biology 2025 Sep 2;8(1):1330
LINC02099 Promotes Retinal Extracellular Matrix Deposition in Diabetic Mice Via the miRNA-214-3p/CTSS Axis.
He Z, Peng X, Feng Y, Li Z, Lu J, Jia A, Bao Y, Li H
Investigative ophthalmology & visual science 2025 Sep 2;66(12):42
Investigative ophthalmology & visual science 2025 Sep 2;66(12):42
A novel chronic hepatitis B mouse model with immune activation and liver fibrosis.
Wu D, Liu Z, Song Z, Yu L, Guan Z, Liu H, Zhao J, Jin Z, He X, Zhang Y, Cao L, Dai G, Huang J, Kang Q
Microbiology spectrum 2025 Sep 2;13(9):e0251324
Microbiology spectrum 2025 Sep 2;13(9):e0251324
Role of NLRP3 in the metabolism of bile acids and gut microbiota in CCl4-induced liver fibrosis.
Feng S, Ran T, Xie X, Zhao X
Microbiology spectrum 2025 Sep 2;13(9):e0014825
Microbiology spectrum 2025 Sep 2;13(9):e0014825
Pancreatic stellate cells promote pancreatic regeneration in chronic pancreatitis via exosomal lncRNA MALAT1-Induced acinar-ductal metaplasia.
Han D, Wen C, Li J, Xu W, Mo W, Dai W, Xu X, Xu X
Biochemical and biophysical research communications 2025 Sep 16;780:152468
Biochemical and biophysical research communications 2025 Sep 16;780:152468
Single-Cell Transcriptomics of Human Pericarotid Lymph Nodes Indicating Stability of Carotid Atherosclerotic Plaques.
Sun T, Wu Y, Liu G, Xue Z, Yu M, Mao B, Han M, Liang X, Ling L, You N, Ji L, Liu H, Xu C, Qin Z, Zhao P, Wang D
Journal of the American Heart Association 2025 Sep 16;14(18):e039777
Journal of the American Heart Association 2025 Sep 16;14(18):e039777
Bruceine D inhibits CAF-promoted angiogenesis of breast cancer via suppressing IL-6-mediated activation of the STAT3/Notch1/VEGFR2 axis.
Ma J, Cao D, Zhang Y, Sun Y, Wu Y, Wang J
European journal of pharmacology 2025 Sep 15;1003:177994
European journal of pharmacology 2025 Sep 15;1003:177994
Menaquinone-4 inhibits the formation and vulnerability of atherosclerotic plaques in apolipoprotein E knockout mice by decreasing the uptake of the oxidized low-density lipoprotein in macrophages.
Yamada A, Koga M, Watase D, Hazekawa M, Harada M, Goto S, Setoguchi S, Matsunaga K
European journal of pharmacology 2025 Sep 15;1003:177970
European journal of pharmacology 2025 Sep 15;1003:177970
Lithospermic acid improves diabetic kidney fibrosis by regulating Piezo1/TGF-β1/Smad signaling pathway.
Yan Y, Wang C, Luo S, Hong T, Niu W, Sun X, Zhang E, Yang M, Li Z, Liu J, Zheng Z, Li J
European journal of pharmacology 2025 Sep 15;1003:177896
European journal of pharmacology 2025 Sep 15;1003:177896
Inhibition of GRK2 mitigates renal fibrosis via oxidative stress pathway.
Cheng J, Jiang X, Deng Q, Ni L, Lin W, Cao W, Ren P, Xu B, Wang Q, Kuai J, Wu Y, Wei W, Wang C
European journal of pharmacology 2025 Sep 15;1003:177887
European journal of pharmacology 2025 Sep 15;1003:177887
Adipose-derived stem cell therapy restores erectile function and promotes endogenous stem cell recruitment in a rat model of cavernous nerve injury.
He HY, Duan SB, He BL, Lu BX, Luo JQ, Liao ZQ, Zhou XC, Zhang HB, Wei AY, He SH
International journal of impotence research 2025 Sep 15;
International journal of impotence research 2025 Sep 15;
Rosmarinic acid confers beneficial effects by specifically activating PRDX1 peroxidase activity.
Shi X, Bai Z, Lin Z, Zhang M, Xie X, Wang X, Yin W
Biochemical and biophysical research communications 2025 Sep 12;779:152457
Biochemical and biophysical research communications 2025 Sep 12;779:152457
Apigenin inhibits endothelial-to-mesenchymal transition of coronary artery endothelial cells and myocardial fibrosis by regulating ribosome biogenesis through GTPBP4 modulation.
Hu X, Yang Z, Tang R, Lv Z, Zou T, Dou Y, Li H
Human cell 2025 Sep 12;38(6):157
Human cell 2025 Sep 12;38(6):157
Urolithin C Ameliorates Hyperuricemia by Mitigating Renal Dysfunction through ROS-p38/ERK MAPK Axis Suppression.
Han Q, Chen N, Peng K, Wang M, Chen M, Mamadalieva NZ, Zhang Y, Liu C, Ren Q
Journal of agricultural and food chemistry 2025 Sep 10;73(36):22485-22501
Journal of agricultural and food chemistry 2025 Sep 10;73(36):22485-22501
Cancer-associated fibroblast-derived extracellular vesicles loaded with GLUT1 inhibitor synergize anti-PD-L1 to suppress tumor growth via degrading matrix stiffness and remodeling tumor microenvironment.
Wu Y, Chen W, Deng J, Zhou X, Chen J, Yang Z, Cao X, Liu J, Tan Q, Zhou E, Li M, Guo M, Jin Y
Journal of controlled release : official journal of the Controlled Release Society 2025 Sep 10;385:113998
Journal of controlled release : official journal of the Controlled Release Society 2025 Sep 10;385:113998
Targeting Ferroptosis Alleviates Pulmonary Arterial Hypertension, Insights from Transcriptomic and Experimental Analyses.
Wang X, Guo Q
Advanced biology 2025 Oct;9(10):e00001
Advanced biology 2025 Oct;9(10):e00001
RNF213 Knockdown and Inflammation Promote Angiogenesis and Phenotype Switching by JAK2/STAT3 Pathway in Moyamoya Disease.
Shen J, Wang Y, Qin Y, Chen G, Xu J, Li Y, Hou Y, Liu Y, Liu W
Molecular neurobiology 2025 Oct;62(10):12938-12950
Molecular neurobiology 2025 Oct;62(10):12938-12950
Disruption of Bile Acid Metabolism in the Gut-Liver Axis Predisposes Mice to Inflammatory Bowel Disease.
Chang H, Jiang Y, Zhao Q, Su Z, Chen M, He Q, Lai J, Jiang Y, Zheng J, Pan R, Shao J, Zhao RC, Chen Y
MedComm 2025 Oct;6(10):e70429
MedComm 2025 Oct;6(10):e70429
Ellagic Acid-Loaded sEVs Encapsulated in GelMA Hydrogel Accelerate Diabetic Wound Healing by Activating EGFR on Skin Repair Cells.
Tian L, Wang Z, Chen S, Guo K, Hao Y, Ma L, Ma K, Chen J, Liu X, Li L, Fu X, Zhang C
Cell proliferation 2025 Oct;58(10):e70064
Cell proliferation 2025 Oct;58(10):e70064
Single-cell multi-omic and spatial profiling of esophageal squamous cell carcinoma reveals the immunosuppressive role of GPR116(+) pericytes in cancer metastasis.
Pei X, Liu Z, Tang L, Zhang J, He Y, Zhuang X, Song Y, Peng S, He Y, Zhao Y, Huang X, Xu Y, Li J, Peng L, Shi X, Zhang F, Liu C, He M, Dai W, Wu L, Law S, Liu J, Wang Z, Li Z, Xu W, Liu Z, Li B
Nature genetics 2025 Oct;57(10):2494-2508
Nature genetics 2025 Oct;57(10):2494-2508
S100A8/9-NLRP3-mediated chronic unresolved inflammation drives cardiac pathologies following invasive pneumococcal disease.
Tousif S, Minassian D, He C, Singh B, Umbarkar P, Bhati AS, Mohasin M, Erdmann N, Xie M, Sethu P, Orihuela CJ, Lal H
Experimental & molecular medicine 2025 Oct;57(10):2344-2363
Experimental & molecular medicine 2025 Oct;57(10):2344-2363
Magnesium ions attenuate tendon graft fibrosis during its ligamentization after ACL reconstruction through modulation of fibroblast to myofibroblast trans-differentiation by promoting PGE2 secretion.
Xu C, Luo Y, Cai Z, Ji J, Guo Z, Cai Z, You C, Zhou Y, Chen Z, Zhang W, Gong N, Wang J
Bioactive materials 2025 Oct;52:474-491
Bioactive materials 2025 Oct;52:474-491
Dapagliflozin ameliorates high glucose-induced epithelial-mesenchymal transition via up-regulating ACE2 mediated by EZH2 in diabetic nephropathy.
Wang S, Zhang X, Chong N, Chen D, Shu J, Wang R, Wang Q, Xu Y
Journal of endocrinological investigation 2025 Oct;48(10):2499-2509
Journal of endocrinological investigation 2025 Oct;48(10):2499-2509
GRK2-mediated phosphorylation and de-succinylation of PKM2 reduce macrophage glycolysis in rheumatoid arthritis.
Yang XZ, Zhang WK, Zhu ZQ, Zhao W, Luo LL, Wang LP, Zhao YJ, Chang Y, Wei W
Acta pharmacologica Sinica 2025 Oct;46(10):2693-2706
Acta pharmacologica Sinica 2025 Oct;46(10):2693-2706
Downregulation of the core circadian gene Nr1d2 in the lacrimal gland contributes to postoperative dry eye disease by impairing lipid metabolism.
Liu S, Huang Y, Chen X, Ren H, Chen J, Mu Q, Zhuang J, Li Y, Qiu J, Yu K, Zhuang J
The ocular surface 2025 Oct;38:290-301
The ocular surface 2025 Oct;38:290-301
FAPI-engineered nanoprobe induces dual-cell ferroptosis therapy and enables light-up magnetic resonance imaging for gastric cancer peritoneal metastasis.
Zhao C, Ren Y, Yang J, Jiang J, Lu Y, Yu X, Feng J, Shen Z, Hu Y
Materials today. Bio 2025 Oct;34:102261
Materials today. Bio 2025 Oct;34:102261
Stepwise targeting hyaluronic acid-based polymeric prodrug for acute kidney injury and prevents its progression to chronic kidney disease.
Zhou LB, Peng XZ, Long HM, Hu JB, Xu JT
Materials today. Bio 2025 Oct;34:102207
Materials today. Bio 2025 Oct;34:102207
Oxymatrine attenuates pulmonary fibrosis via APE1‑mediated regulation of the PINK1/Parkin pathway.
Xu W, Xie T, Zhang B, Zhao J, Zhang L, Zheng Y, Ding Y
Molecular medicine reports 2025 Oct;32(4)
Molecular medicine reports 2025 Oct;32(4)
Resveratrol glycoside inhibits NLRP3/IL-1β/NF-κB to alleviate peritoneal fibrosis in peritoneal dialysis.
Liu K, Huang Y, Xiao W, Liao J, Ouyang S, Liang Y, Fu J
Clinical and experimental nephrology 2025 Oct;29(10):1331-1341
Clinical and experimental nephrology 2025 Oct;29(10):1331-1341
miR-29a-3p participates in the pathogenesis of spontaneous abortion by inhibiting trophoblast function targeting COL4A2/COL5A1.
Chen Q, Huang J, Wu S, Zhang L, Yang X, Sun C, Wu J, Huang X, Zhang W, Wang J
Biochemical pharmacology 2025 Oct;240:117060
Biochemical pharmacology 2025 Oct;240:117060
Peroxisome Proliferator-Activated Receptor Agonist IVA337 Alleviates Inflammation and Fibrosis in MASH by Restoring Lipid Homeostasis.
Li N, Wu S, Li X, Yan M, Ding Y, Zhang L, Brenner DA, Liu X, Kisseleva T
The American journal of pathology 2025 Oct;195(10):1822-1838
The American journal of pathology 2025 Oct;195(10):1822-1838
Histone deacetylase 11 regulates stress granule formation to promote endothelial-to-mesenchymal transition in atherosclerosis.
Ren L, Liu Y, Chen D, Rong X, Wen J, Zheng Z, Chen L, He J, Wang W, Lin R
Biochimica et biophysica acta. Molecular cell research 2025 Oct;1872(7):120026
Biochimica et biophysica acta. Molecular cell research 2025 Oct;1872(7):120026
YY1/INSIG1 enhances atherosclerosis progression by regulating AMPK-mTOR signaling.
Yang M, Zhang J, Xu Z, Yang L, Tang S
Molecular immunology 2025 Oct;186:26-38
Molecular immunology 2025 Oct;186:26-38
Small proline-rich protein 2A drives epithelial remodeling in eosinophilic chronic rhinosinusitis with nasal polyps via SAA2 upregulation.
Xie S, Jiang S, Yuan X, Liu L, Wu M, Gu W, Zhang H, Xie Z, Jiang W, Gao P
The Journal of allergy and clinical immunology 2025 Oct;156(4):1038-1052.e5
The Journal of allergy and clinical immunology 2025 Oct;156(4):1038-1052.e5
Rottlerin inhibits PKCδ to attenuate pulmonary fibrosis by suppressing NLRC4/ASC-mediated pyroptosis.
Wang Y, Zhang T, Gou X, Yuan W, He S, Zhang S, Chen Z, Xu G, Wu D, Xu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157154
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157154
Capsaicin ameliorates cholestasis through modulation of the FXR-SHP and FXR-FGF15 gut-liver axis in mice.
Du H, Luo Y, Zhou N, Wang T, Wang R, Wang Y, Lv C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157130
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157130
Mori fructus-derived extracellular vesicle-like nanoparticles regulate dyslipidemia and prevent atherosclerosis progression via miRNAs.
Sui Y, Sun X, Liu Q, Qi G, Yang Y, Zhang X, Francis OB, Wang Y, Liu R, Li X, Jiang M, Wang X, Zhu Y, Yang M, Li R, Li X, Zhang H, Wang Q, Leng L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157128
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157128
Alpha-tocopheryl quinone attenuates liver fibrosis through enriching Christensenella minuta and modulating bile acids metabolism via gut-liver axis.
Chen J, Zhang L, Chen Y, Yan Y, Lu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157108
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157108
Identification of lactylation-related hub genes as novel therapeutic and diagnostic targets for thoracic aortic dissection.
Peng J, Jiang Z, Song J, Chen J, Fu Z, Zhang H, Zhen J, Tuerdi M, Luo M, Wu J, Sun T
Cellular signalling 2025 Oct;134:111944
Cellular signalling 2025 Oct;134:111944
TNALP promotes epithelial oxidative stress and fibrosis via SIRT3-dependent mechanisms in tracheal injury.
Liu Z, Peng H, Peng M, Liao J, Liu B, Zhuang R, Yang H, Xu L, Li Y, Gao L, Guo S
Cellular signalling 2025 Oct;134:111943
Cellular signalling 2025 Oct;134:111943
Aerobic exercise alleviates chronic allergic airway inflammation by regulating the circMETTL9/EIF4A3/IGFBP3 axis.
Wang H, Jia Y, Ma B, Gao T, Wei H, Li D, Gu J, Chen O, Yue S
Cellular signalling 2025 Oct;134:111889
Cellular signalling 2025 Oct;134:111889
Triamcinolone Acetonide (TCA)-Loaded Biodegradable Microspheres Improve Therapeutic Outcomes in Thyroid-Associated Ophthalmopathy (TAO) by Reducing Fibrosis and Adipogenesis.
Xie B, Xiong W, Zhang F, Cao J, Chenzhao C, Chen X
Journal of biomedical materials research. Part A 2025 Oct;113(10):e38000
Journal of biomedical materials research. Part A 2025 Oct;113(10):e38000
De Novo Discovery of a Macrocyclic Peptide Antagonist of Interleukin-11 with Antirenal Fibrotic Efficacy.
An C, Cai W, Li P, Li J, Zhao N, Yang X, Li K, Pang N, Cheng X, Wang N, Guo D, Yin Y, Xiong X
Journal of medicinal chemistry 2025 Oct 9;68(19):20377-20388
Journal of medicinal chemistry 2025 Oct 9;68(19):20377-20388
Geniposide alleviates kidney fibrosis by targeting STAT3-HK2-mediated glycolysis.
Shi R, Liu MQ, Xiao JP, Zhu YK, Zhu JX, Zhao WM, Wang ZJ, Zhu YY, Li XL, Wang XR, Wang RF, Wang DG
BMC complementary medicine and therapies 2025 Oct 9;25(1):365
BMC complementary medicine and therapies 2025 Oct 9;25(1):365
Liver-Targeted Scutellarin Nanoemulsion Alleviates Fibrosis with Ancillary Modulation of the Gut-Liver Microbiota.
Yu H, Niu X, Niu B, Lei P, Xu N, Yang S, Yu Q, Li G, Wang L
International journal of molecular sciences 2025 Oct 7;26(19)
International journal of molecular sciences 2025 Oct 7;26(19)
Injectable Immune-Regulating Mesenchymal Stem Cells Hydrogel for Localized Scleroderma Treatment.
Liu R, Kong B, Lu J, Zhao Y, Sun L
ACS nano 2025 Oct 7;19(39):34785-34796
ACS nano 2025 Oct 7;19(39):34785-34796
Development of a potent BET inhibitor for the treatment of renal fibrosis.
Huang J, Zhao N, Li J, Zhu J, Liang G, Chen X, Wang N, Zhu H, Pang N, An C, Xiong X
European journal of medicinal chemistry 2025 Oct 5;295:117822
European journal of medicinal chemistry 2025 Oct 5;295:117822
Wuhu decoction regulates ROS/AMPK/mTOR pathway-mediated dendritic cells autophagy and pyroptosis for the treatment of respiratory syncytial virus-induced asthma.
Ding Y, Luo J, Deng YJ, Liu JL, Wang MQ, Hu Y
Journal of thoracic disease 2025 Oct 31;17(10):7810-7825
Journal of thoracic disease 2025 Oct 31;17(10):7810-7825
FAM3B activates hepatic stellate cells to accelerate hepatic fibrosis by promoting glucose metabolism.
Wei WJ, Lin C, Luo SH, Huang JJ, Hu RT, Li JX, Ma HZ, Wei JZ, Wang CF, Lim CS, Deng YB
Biochemical and biophysical research communications 2025 Oct 30;786:152703
Biochemical and biophysical research communications 2025 Oct 30;786:152703
Anemoside B4 improves cardiac function after myocardial infarction by regulating HTR2A/ERK pathway.
Lv M, Sun Q, Yu Y, Yu D
International immunopharmacology 2025 Oct 30;164:115394
International immunopharmacology 2025 Oct 30;164:115394
PGRN mediates the crosstalk between ovarian cancer cells and CAFs and reshapes tumor immune microenvironment.
Ning X, Wang Y, Zhai L, Gao W, Jin Z, Iqbal H, Ur-Rehman U, Gao L, Lv M, Yuan Z, Yi Z, Wang B, Chen W, Ma R, Xiao R
International immunopharmacology 2025 Oct 30;164:115362
International immunopharmacology 2025 Oct 30;164:115362
Senkyunolide I targets CXCR4 to attenuate liver fibrosis via suppression of the NLRP3/GSDMD pathway.
Wang K, Yang Y, Yue B, Li M, Chen C, Du J, Long F
International immunopharmacology 2025 Oct 30;164:115348
International immunopharmacology 2025 Oct 30;164:115348
Canagliflozin inhibits hepatic stellate cells activation and proliferation by inhibiting PP2A-mediated β-catenin dephosphorylation to attenuate hepatic fibrosis.
Peng L, Zou Z, Zhou L, Li L, Lu W, Chen C, Xu Y, Liu Y, Lin J, Ye J
International immunopharmacology 2025 Oct 30;164:115347
International immunopharmacology 2025 Oct 30;164:115347
MBD2 deficiency attenuates CCl(4)-induced hepatic fibrosis by inhibiting M2 macrophage polarization.
Yu W, Li R, Wang Y, Wang YN, Huang Y, Zhang Y, Nie H, Liu L, Chen H, Zheng B, Gong Q
International immunopharmacology 2025 Oct 30;164:115306
International immunopharmacology 2025 Oct 30;164:115306
EphrinB2 in dental pulp stem cells promotes endothelial cells forming capillary-like cords in a 3D bioprinted hydrogel construct.
Wang W, Li J, Zhou Y, Ren T, Yang Y, Li M, Tian H, Wang P, Yuan C
BMC molecular and cell biology 2025 Oct 29;26(1):33
BMC molecular and cell biology 2025 Oct 29;26(1):33
Fusobacterium nucleatum increases CTGF expression through TLR2-YAP signaling axis in cancer-associated fibroblasts, thereby promoting colorectal cancer progression.
Wang H, Lin B, Wang Z, Yang J, Guo X, Li W, Li B, Shi S, Zhou Y, Han R, Wei Y, Liu Y
Cancer cell international 2025 Oct 28;25(1):381
Cancer cell international 2025 Oct 28;25(1):381
Mesenchymal stem cells inhibit mitochondrial fission by upregulating armadillo repeat containing 1, ameliorating oxidative stress in renal fibrosis.
Li T, Guo C, Liu Q, Jing F, Zhao M, Xiong H, Li C, Zhang W, Chen B
Stem cell research & therapy 2025 Oct 28;16(1):584
Stem cell research & therapy 2025 Oct 28;16(1):584
Design and Synthesis of Senescence-Targeted Prodrugs with Senomorphic and Senolytic Properties To Mitigate Chemotherapy-Induced Kidney Injury.
Ding L, Wang X, Liu Q, Zhang Y, Wu X, Xiao B, Liu D, Chen L, Zeng H, Zhao B, Dong C, Li L, Ge G, Jia L, Ni S
Journal of medicinal chemistry 2025 Oct 23;68(20):21458-21478
Journal of medicinal chemistry 2025 Oct 23;68(20):21458-21478
Long-Term Maternal Exposure to Triclosan Provokes Pulmonary Fibrosis in Mouse Offspring.
Liu J, Guo M, Li W, Yang B, Song Y
Environment & health (Washington, D.C.) 2025 Oct 17;3(10):1164-1174
Environment & health (Washington, D.C.) 2025 Oct 17;3(10):1164-1174
MIF Promotes Phenotypic Switching of VSMCs via AKT/mTOR-Mediated Autophagy Regulation in Aortic Dissection.
Pu Y, Zhou Y, Guo T, Pan X, Sun X, Yang G, Chai X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71079
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71079
Nephroprotective mechanism of Kunkui Baoshen decoction in diabetic kidney disease: Targeting the HERC2/NCOA4-mediated autophagy-dependent ferroptosis pathway.
Song SY, Shan CC, Zhou PP, Xu WL, Tan Y, Zhou XQ, Huang LJ, Yan QH, Yu JY
World journal of diabetes 2025 Oct 15;16(10):109568
World journal of diabetes 2025 Oct 15;16(10):109568
Transcription factor MEOX1 accelerates pulmonary fibrosis by regulating mitophagy and senescence.
Fang L, Lyu L, Zhong H, Lin J, Ren P, Wang Y, Yin Y, Zhang M, Qu Y
European journal of pharmacology 2025 Oct 15;1005:178043
European journal of pharmacology 2025 Oct 15;1005:178043
Albiflorin attenuates post-myocardial infarction cardiac fibrosis through inhibiting the RAS-ERK/MAPK signaling pathway.
Lv M, Yu Y, Niu H, Yu D
Biochemical and biophysical research communications 2025 Oct 1;783:152644
Biochemical and biophysical research communications 2025 Oct 1;783:152644
Mechanism of silica nanoparticles induced pulmonary epithelial-mesenchymal transition mediated by exosomal HNRNPAB.
Zhao X, Pan Y, Yan G, Yu Y, Song Y
Ecotoxicology and environmental safety 2025 Oct 1;304:119162
Ecotoxicology and environmental safety 2025 Oct 1;304:119162
Bioinspired Multifunctional Hydrogel Loaded with Netrin-1 for Diabetic Wound Healing.
Chen J, Wang X, Yuan X, Zou H, Li J, Chen G, Tan Q
ACS applied materials & interfaces 2025 Oct 1;17(39):54525-54536
ACS applied materials & interfaces 2025 Oct 1;17(39):54525-54536
Faecalibacterium prausnitzii alleviates Graves' orbitopathy by modulating short-chain fatty acid (SCFA) metabolism and inhibiting orbital fibrosis and adipogenesis.
Qi X, Zhang J, Li Y, Shi Y, Yao J, Tong B
Archives of biochemistry and biophysics 2025 Nov;773:110588
Archives of biochemistry and biophysics 2025 Nov;773:110588
m(6)A deficiency impairs uterine spiral artery remodeling to induce preeclampsia-like symptoms via FGF2.
Liu S, Chen W, Chen J, Liu T, Deng M, Xia L, Li Z, Shi J, Li Y, Peng Y, Ren Q, Miao Z, Wu G, Cao X, Xiao S, Zhang J, Zhong M, Wang L, Xia L
Science China. Life sciences 2025 Nov;68(11):3138-3150
Science China. Life sciences 2025 Nov;68(11):3138-3150
A contractility-competent immortalized human sweat gland myoepithelial line with dual epithelial-mesenchymal characteristics.
Liu L, Yao T, Ren S, Liu J, Li N
Burns : journal of the International Society for Burn Injuries 2025 Nov;51(8):107659
Burns : journal of the International Society for Burn Injuries 2025 Nov;51(8):107659
Interleukin 33 Promotes Liver Sinusoidal Endothelial Cell Dysfunction and Hepatic Fibrosis in Diabetic Mice.
Chen H, Gao C, Mo L, Yin X, Chen L, Wu B, Zhao Y, Cheng X, Liang C, Xu B, Li D, Li Y, Yao P, Tang Y
Diabetes & metabolism journal 2025 Nov;49(6):1204-1218
Diabetes & metabolism journal 2025 Nov;49(6):1204-1218
Porous chitin nanofibers combined with adipose-derived stem cells promote diabetic wound healing via PPAR-γ activation.
Zhang Z, Zheng Y, Wang Z, Li Y, Liu Y, Luo Z
International journal of biological macromolecules 2025 Nov;330(Pt 1):147763
International journal of biological macromolecules 2025 Nov;330(Pt 1):147763
LncRNA LINC01605 Regulates Smooth Muscle Cell Functions and Participates in the Development of Aortic Dissection Through Regulating SGK1.
Li M, Li R, Zheng Z, Xiao C, Yang Q, Chen B, Dai X
Journal of cellular and molecular medicine 2025 Nov;29(22):e70963
Journal of cellular and molecular medicine 2025 Nov;29(22):e70963
Asiaticoside and asiatic acid improve diabetic nephropathy by restoring podocyte autophagy and improving gut microbiota dysbiosis.
Ni Y, Pan Y, Zhou J, Du H, Yang W, Zheng L, Zheng Y, Jin H, Fu Z, Cai C, He Q, Jin J
Biochemical pharmacology 2025 Nov;241:117161
Biochemical pharmacology 2025 Nov;241:117161
Aristolochic acid I promotes renal tubulointerstitial fibrosis by activating the mannan-binding lectin serine protease 1-complement system.
Wang C, Zhang H, Wang J, Wu H, Ye J, Zhang Q, Jiang B, Chen L, Wang Y, Cheng S, Ying J, Xiang Y, Cheng Y, Zhang L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Nov;205:115708
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Nov;205:115708
An Ile to Met polymorphism in ADCY9 promotes airway obstruction and remodeling in asthma.
Liang LM, Cai PC, Yu F, He XL, Song LJ, Lu YZ, Niu Q, Zhou YY, Jiang LJ, Jiang YH, Jia ZH, Zhao LQ, Wang M, Cheng PP, Chen SJ, Feng X, Li Q, Cui XL, Xiong L, Xiang F, Wang X, Ye H, Ma WL
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):168015
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):168015
Quercetin ameliorates renal injury by promoting UCP1-mediated alleviation of lipid accumulation in diabetic kidney disease.
Yong W, Li Z, Xu W, Gao D, Sha B, Jin Y, Shen Y, Zhang Y, Pan Y, Liu J, Zhang F, Yu J, Jin L, Yang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157213
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157213
The total xanthones from Gentianella acuta alleviate acute myocardial infarction by targeting BRD4-mediated cardiomyocyte pyroptosis and inflammation.
Dai C, Sun J, Yang G, Zhang C, Zhang Y, Song Q, Liu X, Duan X, Yang H, Li A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157156
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157156
Fucoxanthin ameliorates vascular remodeling via attenuating oxidative stress in hypoxic pulmonary hypertension rats.
Zheng X, Zhao J, Jia X, Pan J, Xu S, Wang D, Li J, Ji Y, Zhu Z, Hasnain M, Sui Z, Wang R, Yuan Y
The Journal of nutritional biochemistry 2025 Nov;145:110002
The Journal of nutritional biochemistry 2025 Nov;145:110002
Self-Assembled Tetrahedral Framework Nucleic Acids Alleviate Pulmonary Hypertension by Regulating Calcium Homeostasis.
Yang L, Hou W, Lan J, Liu R, Zhao L, Zhang C, Fu D, Yin H, Li D, Sun SK, Yu J
Advanced healthcare materials 2025 Nov;14(30):e02810
Advanced healthcare materials 2025 Nov;14(30):e02810
Resident Macrophage-Orchestrated Immune and Fibroblast Interactions in Immune Checkpoint Inhibitor-Associated Nephrotoxicity.
Ma Y, Chen Y, Yao Q, Wang Y, Ouyang N, Han F, Wang G, Wang M, Yuan Y, Chen J, Shan J, Chen D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e05445
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e05445
A mitochondria-targeted nanomedicine for myocardial ischemia/reperfusion injury with synergistic antioxidant and anti-inflammatory properties.
Li C, Zhang Z, Luo C, Lan W, Liu C, Liu W, Xiang H, Yang J, Tang Y, Wang X
Journal of nanobiotechnology 2025 Nov 5;23(1):705
Journal of nanobiotechnology 2025 Nov 5;23(1):705
TGF-β1 mediates epithelial-mesenchymal transition in interstitial cystitis through the regulation of ROCK.
Long X, Yu B, Chen M, Zhang Q, Wang Y, Huang Y, Wu J, Cen P, Lan H, Long J, Zhang Z, Zhong J, Duan X, Yu Q, Gu D
European journal of pharmacology 2025 Nov 5;1006:178184
European journal of pharmacology 2025 Nov 5;1006:178184
From Gene to Scar: Proteome-Wide Causal Insights into Keloid Pathogenesis and Prevention.
Xu Y, Liu JC, Jiang Z, Zhang J, He R, Wan M, Zhao S
Advances in wound care 2025 Nov 5;
Advances in wound care 2025 Nov 5;
Mfn2 Regulates Scleral Remodeling in Myopia by Maintaining Endoplasmic Reticulum Homeostasis in Scleral Fibroblasts.
Wang Y, Liu S, Huang Q, Cheng Y
Investigative ophthalmology & visual science 2025 Nov 3;66(14):40
Investigative ophthalmology & visual science 2025 Nov 3;66(14):40
Dapagliflozin ameliorates high glucose-induced peritoneal fibrosis through downregulation of ENKUR/PI3K/AKT signaling pathway.
Liu J, Xu X, Zhang L, Jiang T, Zhao Z, Xiao J
Scientific reports 2025 Nov 3;15(1):38334
Scientific reports 2025 Nov 3;15(1):38334
Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway.
Li Z, Zhao M, Ma S, Lei S
European journal of medical research 2025 Nov 27;30(1):1292
European journal of medical research 2025 Nov 27;30(1):1292
CAFs-derived SPI1 in tumor fibroblasts promotes malignant behaviors of liver cancer cells and immune escape by regulating HRAS and PD-L1 transcription.
Miao K, Zhou J, Chen J
Hereditas 2025 Nov 26;162(1):233
Hereditas 2025 Nov 26;162(1):233
Extracellular matrix anchored neutrophils drive pulmonary fibrosis in mice.
Yang L, Sun P, Wang J, Xu M, Zhu B, Yu K, Rong Y, Mao R, Zi S, Liu C, Huang J, Ma J, Chen H, Luo W, Zhang W, Zhang X, Fang S, Chao J
Nature communications 2025 Nov 26;16(1):11655
Nature communications 2025 Nov 26;16(1):11655
An integrated study on the role and underlying mechanism of QingFei Oral solution in pulmonary hypertension.
Zou X, Cai A, Cheng Y, Li X, Chen Y, Li W, Zhang Y, Pan Z, Liu Y, Zhang Y, Liu T, Huang P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157311
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157311
Dynamic remodelling of epithelial plasticity in colorectal cancer from single-cell and spatially resolved perspectives.
Xu C, Pan Y, Zhang S, Lin M, Liu H, Yu Z
Journal of translational medicine 2025 Nov 24;23(1):1341
Journal of translational medicine 2025 Nov 24;23(1):1341
The TRPV4-YAP axis mediates cytoskeletal and extracellular matrix remodeling in trabecular meshwork cells as a novel glaucoma mechanism.
Xu J, Liu K, Wang F, Su Y
Scientific reports 2025 Nov 24;15(1):41644
Scientific reports 2025 Nov 24;15(1):41644
HMGA1 drives EMT in obliterative bronchiolitis through epigenetic regulation of chromatin accessibility in pulmonary epithelial cells.
Xia T, Hou Z, Wang S, Sun J, Yang H, Miao P, Liu C, Zheng W, Wei L
Clinical epigenetics 2025 Nov 18;17(1):192
Clinical epigenetics 2025 Nov 18;17(1):192
Synergistic promotion of bone regeneration through co-culture of endothelial cells with mesenchymal stem cells in endochondral ossification organoids.
Su Y, He Z, Li J, Chen Q, Wang D, Yang Z, Yuan Y, Chen L, Ye F, Xing D, Li H, Lin J
Stem cell research & therapy 2025 Nov 18;16(1):647
Stem cell research & therapy 2025 Nov 18;16(1):647
SHP1 overexpression ameliorates renal fibrosis via inhibition of STAT3 signaling and glycolysis reprogramming.
Tian H, Liu B, Liu W, Yang J, Pan T
Scientific reports 2025 Nov 18;15(1):40429
Scientific reports 2025 Nov 18;15(1):40429
Epigenetic silencing of MSTN via m6A modification underlies the renoprotective effects of engineered MSC exosomes with RBM15 depletion in diabetic nephropathy.
Dong Q, Dong L, Zhu Y, Wang X, Yan X
Functional & integrative genomics 2025 Nov 17;25(1):244
Functional & integrative genomics 2025 Nov 17;25(1):244
Berberine ameliorates atherosclerosis by inhibiting the phenotypic transition of vascular smooth muscle cells via suppression of the JAK2/STAT3 signaling pathway.
Zheng J, Wang T, Zhou Y, Chen Y, Shen X, Jin B, Han X, Hua C, Xie J
European journal of pharmacology 2025 Nov 15;1007:178234
European journal of pharmacology 2025 Nov 15;1007:178234
Therapeutic potential of the LUCAT1/miR- 2278/STAT5A axis in pulmonary fibrosis.
Huang J, Zhang W
BMC pulmonary medicine 2025 Nov 14;25(1):528
BMC pulmonary medicine 2025 Nov 14;25(1):528
Curcumenol exerts anti-pulmonary fibrosis effects through modulation of the immune signature target SPP1: based on comprehensive bioinformatics and experiments validation.
Li C, Wen R, Xiong Y, Tan QW, Zhai XY, Xiong Y, Dai LS
International immunopharmacology 2025 Nov 14;165:115469
International immunopharmacology 2025 Nov 14;165:115469
Sotagliflozin attenuates atrial oxidative stress and the susceptibility to atrial fibrillation by activating the NRF2/HO-1 pathway.
Li F, Xie M, Zeng G, Zhu J, Zhou J, Tan S, Lin Q, Liu Q
International immunopharmacology 2025 Nov 14;165:115461
International immunopharmacology 2025 Nov 14;165:115461
AARS1 promotes endometriosis progression by promoting the lactylation of Snail1†.
Liu L, Du S, Liu J, Wang M, Ge X, Yue C, Lu C, Yu Z
Biology of reproduction 2025 Nov 14;113(5):1209-1218
Biology of reproduction 2025 Nov 14;113(5):1209-1218
Comprehensive pan-cancer analysis of USP35 and validation of its role in gastric cancer.
Yan L, Zhang Y, Wang S, Qin J, Chen M, Zou D, Zhang L, Wu L, Zhang Y
Human genomics 2025 Nov 12;19(1):134
Human genomics 2025 Nov 12;19(1):134
Context-dependent contribution of peptidyl arginine deiminase 4 (PAD4) to neutrophil extracellular trap formation and liver injury in acute and chronic hepatotoxicant challenge.
Capece GE, Patel AK, Hu D, Roychowdhury T, Hazel B, Kothapalli J, Mac NA, Denorme F, Campbell RA, Poole LG
Toxicological sciences : an official journal of the Society of Toxicology 2025 Nov 1;208(1):136-154
Toxicological sciences : an official journal of the Society of Toxicology 2025 Nov 1;208(1):136-154
Targeting PIM1 by Bruceine D attenuates skin fibrosis via myofibroblast ferroptosis.
Wang J, Song Y, Tan X, Wang T, Shi Y, Xu X, Du J, Yu Z, Song B
Redox biology 2025 May;82:103619
Redox biology 2025 May;82:103619
Tryptanthrin alleviate lung fibrosis via suppression of MAPK/NF-κB and TGF-β1/SMAD signaling pathways in vitro and in vivo.
Niu M, Wang YZ, Deng XM, Wu X, Hua ZY, Lv TT
Toxicology and applied pharmacology 2025 May;498:117285
Toxicology and applied pharmacology 2025 May;498:117285
Ras Guanine Nucleotide-Releasing Protein-4 Inhibits Erythropoietin Production in Diabetic Mice with Kidney Disease by Degrading HIF2A.
Wang J, Huang S, Zhang L, He Y, Shao X, A-Ni-Wan AS, Kong Y, Meng X, Yu P, Zhou S
Diabetes & metabolism journal 2025 May;49(3):421-435
Diabetes & metabolism journal 2025 May;49(3):421-435
Identification of potential mechanisms of Schisandrin B in the treatment of idiopathic pulmonary fibrosis by integrating network pharmacology and experimental validation.
Pan T, Wu J, Qiu X, Zhu D, Wang J, Li T, Wang Z, Feng F, Xu Y, Zhou X
Naunyn-Schmiedeberg's archives of pharmacology 2025 May;398(5):5389-5403
Naunyn-Schmiedeberg's archives of pharmacology 2025 May;398(5):5389-5403
Dihydroartemisinin requires NR1D1 mediated Rab7 ubiquitination to regulate hepatic stellate cells lipophagy in liver fibrosis.
Bao Z, Xu M, Kan Y, Guo X, Li M, Wang J, Zhou Y, Zhang Z, Shao J, Zhang F, Chen L, Zheng S, Xuan J
International journal of biological macromolecules 2025 May;305(Pt 1):141055
International journal of biological macromolecules 2025 May;305(Pt 1):141055
Thrombospondin-1 binds to integrin β3 to inhibit vascular calcification through suppression of NF-κB pathway.
Liu F, Liang Q, Li L, Gong Y, Li M, Feng L, Chen A, Ye Y, Lan Z, Li Y, Ou JS, Lu L, Yan J
The Journal of pathology 2025 May;266(1):109-123
The Journal of pathology 2025 May;266(1):109-123
Adipose stem cells ameliorate erectile dysfunction in diabetes mellitus rats by attenuating ferroptosis through NRP1 with SLC7A11 interaction.
Luo JQ, Wang L, Liao ZQ, Lu BX, Luo CY, He HY, Ou Yang ZH, Duan SB, He SH, Wei AY, Zhang HB
Free radical biology & medicine 2025 May;232:40-55
Free radical biology & medicine 2025 May;232:40-55
A Keap1-recruiting BRD4 degrader offers a single-molecular polypharmacology approach for the treatment of metabolic dysfunction-associated steatohepatitis.
Zhang X, Ge Y, Ye M, Wang X, Tong Y, Liu C, Xu S, Zhao Z, You Q, Guo X, Jiang Z
Free radical biology & medicine 2025 May;232:15-27
Free radical biology & medicine 2025 May;232:15-27
Breaking the synergism of iron overload and miR-122 to rescue lipid accumulation and peroxidation in MASLD.
Tang Y, Gao Z, Yang J, Li C, Wang W, Wu C, Wu M, Li M, Wu H, Sun Y, Zhang H, Chai Y, Xie F, Qian J, Shen H, Wang D
Pharmacological research 2025 May;215:107728
Pharmacological research 2025 May;215:107728
Porcine plasma protein cold-set hydrogel crosslinked by genipin and the immunomodulatory, proliferation promoting and scar-remodeling in wound healing.
Li H, Wu M, Ma Z, Wang X, Fan J, Hu K, Wei Y, Yao C, Liu J, Kang S, Kang X, Yuan J
Biomaterials advances 2025 May;170:214216
Biomaterials advances 2025 May;170:214216
Epithelial-Mesenchymal Plasticity in the D-Meso-Sonobe Mesothelioma Cell Line: A Putative Model of Epithelial-Mesenchymal Transition in Mesothelioma.
Okubo H, Hanamatsu Y, Saigo C, Hiroshi S, Takeuchi T
Thoracic cancer 2025 May;16(10):e70091
Thoracic cancer 2025 May;16(10):e70091
GRB2 Promotes Malignant Behaviors of Breast Cancer by Modulating the Global Expression and Alternative Splicing Profiles in SK-BR-3 Cells Through Binding mRNA.
Liu W, Huang Y, Qiao L, Chong L, Xia L, Abudurehaman A, Li H
Cancer medicine 2025 May;14(10):e70905
Cancer medicine 2025 May;14(10):e70905
Syntaxin 17 Translocation Mediated Mitophagy Switching Drives Hyperglycemia-Induced Vascular Injury.
Luo A, Wang R, Gong J, Wang S, Yun C, Chen Z, Jiang Y, Liu X, Dai H, Liu H, Zheng Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2414960
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(19):e2414960
CILP1 interacting with YBX1 promotes hypertrophic scar formation by suppressing PPARs transcription.
Wang J, Du J, Song Y, Tan X, Wu J, Wang T, Shi Y, Xu X, Yu Z, Song B
Cell death & disease 2025 May 9;16(1):371
Cell death & disease 2025 May 9;16(1):371
Bladder patch repair using mesothelial Cell-Seeded autologous granulation tissue: an experimental study in male rabbits.
Yang L, Liu Z, Yan L, Sui Y, Qiu L, Sun Y, Zheng J, Sun J, Chang Q, Gu G
World journal of urology 2025 May 7;43(1):278
World journal of urology 2025 May 7;43(1):278
Immunodynamic axis of fibroblast-driven neutrophil infiltration in acute pancreatitis: NF-κB-HIF-1α-CXCL1.
Wang Q, Zhang X, Han C, Lv Z, Zheng Y, Liu X, Du Z, Liu T, Xue D, Li T, Wang L
Cellular & molecular biology letters 2025 May 7;30(1):57
Cellular & molecular biology letters 2025 May 7;30(1):57
Methyltransferase-like 3-catalysed N6-methyladenosine methylation facilitates the contribution of vascular smooth muscle cells to atherosclerosis.
Dong Z, Jin Y, Shen Y, Huang J, Tan J, Feng Q, Gong Z, Zhu S, Chen H, Yu F, Li W, Jia Y, Kong W, Fu Y
Cardiovascular research 2025 May 6;121(4):568-584
Cardiovascular research 2025 May 6;121(4):568-584
Pulmonary Injury Induced via Metal-Organic Frameworks (MOFs): ROS Generation and Inflammatory Responses Mediated by HKUST-1.
Zhang Y, Xue Z, Yang Z, Chen M, Zhou L, Zhou L, Zhu M, Huang Z, Li Y, Kang S, Zheng L, Zhang D
ACS omega 2025 May 6;10(17):17865-17874
ACS omega 2025 May 6;10(17):17865-17874
SMYD2 Promotes Renal Tubular Cell Apoptosis and Chronic Kidney Disease Following Cisplatin Nephrotoxicity.
Zuo S, Yuan H, Li X, Chen M, Peng R, Chen S, Zou X, Yang Y, Long H, Liu Z, Wang T, Guo B, Liu L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70651
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 31;39(10):e70651
Gestational Exposure to Phenanthrene Induces Superfluous Fibrosis and Calcification and Metabolic Imbalance of the Placenta in Mice.
Zheng Y, Lan T, Zhang Z, He X, Yang M, Li X, You J, Gu H, Nashun B, Guo J
Journal of agricultural and food chemistry 2025 May 28;73(21):12949-12960
Journal of agricultural and food chemistry 2025 May 28;73(21):12949-12960
Serum-free endothelial cell culture medium for vascular smooth muscle cells sheet formation.
Yang J, Sun X, Jiang H, Li J, Liang J, Lin Z
Journal of biological engineering 2025 May 28;19(1):51
Journal of biological engineering 2025 May 28;19(1):51
Saliva-derived extracellular vesicles: a promising therapeutic approach for salivary gland fibrosis.
Peng B, Guo X, Kang J, Pan S, Wei L, Wang L, Li B, Han G, Cheng Y
Journal of translational medicine 2025 May 27;23(1):593
Journal of translational medicine 2025 May 27;23(1):593
The oncogenic role of TIMM8A in cancer and the mechanistic insights into the function in breast cancer cells.
Wang W, Liu M, Wu H, Li J, Lv W, Li C, Du C, Feng C, Zhang Y, Cai Y, Jia Y, Hu Y, Qu J, Zhang S, Wu F
Scientific reports 2025 May 26;15(1):18374
Scientific reports 2025 May 26;15(1):18374
Hypoxia-inducible factor-1 alpha (HIF-1α) inhibitor AMSP-30 m attenuates CCl(4)-induced liver fibrosis in mice by inhibiting the sonic hedgehog pathway.
Lu L, Ma Y, Tao Q, Xie J, Liu X, Wu Y, Zhang Y, Xie X, Liu M, Jin Y
Chemico-biological interactions 2025 May 25;413:111480
Chemico-biological interactions 2025 May 25;413:111480
Hepatocyte-specific CLSTN3B ablation impairs lipid droplet maturation and alleviates diet-induced steatohepatitis in mice.
Zhang C, Yang D, Suzuki H, Chen J, Wang J, Ye M, Zhou J, Zeng Q, Bai M, Lin MJ, Lee J, Zhu H, Hoshida Y, Zeng X
bioRxiv : the preprint server for biology 2025 May 25;
bioRxiv : the preprint server for biology 2025 May 25;
Delivery of bone marrow mesenchymal stem cell-derived exosomes into fibroblasts attenuates intestinal fibrosis by weakening its transdifferentiation via the CCN2-TGF-β axis.
Ling F, Yang W, Yuan M, Chen Y, Li J, Wu J, Zhu L
Scientific reports 2025 May 23;15(1):18048
Scientific reports 2025 May 23;15(1):18048
Porphyromonas gingivalis aggravates atherosclerotic plaque instability by promoting lipid-laden macrophage necroptosis.
Huang X, Xie M, Wang Y, Lu X, Mei F, Zhang K, Yang X, Chen G, Yin Y, Feng G, Song W, Dong N, Deng X, Wang S, Chen L
Signal transduction and targeted therapy 2025 May 23;10(1):171
Signal transduction and targeted therapy 2025 May 23;10(1):171
Asb10 accelerates pathological cardiac remodeling by stabilizing HSP70.
Lin K, Wei W, Chen S, Gong Y, Wang X, Wang M, Li R, Zhao Y, Xu S, Jin C, Jiang C, Fu G, Li Q
Cell death & disease 2025 May 22;16(1):409
Cell death & disease 2025 May 22;16(1):409
LONP1 facilitates pulmonary artery smooth muscle cell glycolytic reprogramming by degrading MPC1 in pulmonary hypertension.
Li M, Zhang W, Zhang M, Li L, Yao Y, Qin Y, Wang D, Yan G, Qiao Y, Tang C
Clinical science (London, England : 1979) 2025 May 20;139(10):479-501
Clinical science (London, England : 1979) 2025 May 20;139(10):479-501
Tetrathiomolybdate alleviates bleomycin-induced pulmonary fibrosis by reducing copper concentration and suppressing EMT.
Wang Y, Chen S, Zhou Z, Jiang J, Chen S
European journal of medical research 2025 May 19;30(1):394
European journal of medical research 2025 May 19;30(1):394
The integrated single-cell analysis interpret the lactate metabolism-driven immune suppression in triple-negative breast cancer.
Gao X, Wang T, Liu C, Li Y, Zhang W, Zhang M, Yao Y, Gao C, Liu R, Sun C
Discover oncology 2025 May 16;16(1):784
Discover oncology 2025 May 16;16(1):784
Urolithin A enhances diabetic wound healing: Insights from parkin-mediated mitophagy in endothelial progenitor cells.
Fang X, Shao Z, Ding H, Xu H, Tu Z, Wang H, Li D, Huang C, Jiang C
International immunopharmacology 2025 May 16;155:114572
International immunopharmacology 2025 May 16;155:114572
Astragaloside IV prevents liver fibrosis by blocking glycolysis-mediated macrophage M1 polarization.
Hu Y, Kuang M, Song H, Tan Y, Zhou F, Pei G, Jiao L
European journal of pharmacology 2025 May 15;995:177353
European journal of pharmacology 2025 May 15;995:177353
Orai1 Participates in Coronary Artery Dysfunction Caused by Hypertension via Regulating Smooth Muscle Cell Phenotype Transformation.
Wang H, Liang MY, Cai YJ, Deng CY, Yang H, Mai LP, Zhang MZ, Kuang SJ, Rao F, Xu JS
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 15;39(9):e70576
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 15;39(9):e70576
Exploring the wound-healing mechanism of Cayratia japonica extract: A combined experimental and network pharmacology study.
Cheng M, Hou Y, Chen Q, Ge S, Chen C, Zheng X, Zhang C
Journal of ethnopharmacology 2025 May 12;347:119810
Journal of ethnopharmacology 2025 May 12;347:119810
Urolithin B suppresses phenotypic switch in vascular smooth muscle cells induced by PDGF-BB via inhibiting the PI3K-AKT pathway.
Li S, Zhang Y, Zhang T, Jiang D, Li M, Chen L, Jiang J, Zhang C, Li Q
In vitro cellular & developmental biology. Animal 2025 Mar;61(3):311-319
In vitro cellular & developmental biology. Animal 2025 Mar;61(3):311-319
Ergothioneine Ameliorates Liver Fibrosis by Inhibiting Glycerophospholipids Metabolism and TGF-β/Smads Signaling Pathway: Based on Metabonomics and Network Pharmacology.
Mao Y, Xie Z, Zhang X, Fu Y, Yu X, Deng L, Zhang X, Hou B, Wang X, Ma M, Ren F
Journal of applied toxicology : JAT 2025 Mar;45(3):514-530
Journal of applied toxicology : JAT 2025 Mar;45(3):514-530
Dihydrotanshinone I Attenuates Diet-Induced Nonalcoholic Fatty Liver Disease via Up-Regulation of IRG1.
Xiang Y, Kuang G, Gong X, Xie H, Lin Y, Zhang X, Chen Z, Wan J, Li Z
Phytotherapy research : PTR 2025 Mar;39(3):1531-1548
Phytotherapy research : PTR 2025 Mar;39(3):1531-1548
Bergapten Ameliorates Renal Fibrosis by Inhibiting Ferroptosis.
Li L, Cai W, Zhang H, Tang J, Yang Y, Huang Y, Xi Q, Zhang R
Phytotherapy research : PTR 2025 Mar;39(3):1355-1371
Phytotherapy research : PTR 2025 Mar;39(3):1355-1371
Conductive hyaluronic acid/phytanic acid hydrogel to deliver recombinant human amelogenin for diabetic wound repair.
Cui X, Yue Y, Li Z, Shi X, Qian C, Liu Z, Lin J
International journal of biological macromolecules 2025 Mar;297:139864
International journal of biological macromolecules 2025 Mar;297:139864
ROS scavenging and corneal epithelial wound healing by a self-crosslinked tissue-adhesive hydrogel based-on dual-functionalized hyaluronic acid.
Pan XY, Wang ZH, Wu XQ, Guo CR, Yang LX, Liu HR, Wang YH, Chen WJ, Wang JJ, Nan KH, Li LL
International journal of biological macromolecules 2025 Mar;293:139200
International journal of biological macromolecules 2025 Mar;293:139200
Kindlin-3 Promotes Angiogenesis via Notch Signalling and Is Crucial for Functional Recovery Postmyocardial Infarction.
Sun Y, Zheng W, Liu X, Wang K, Xu D
Journal of cellular and molecular medicine 2025 Mar;29(6):e70494
Journal of cellular and molecular medicine 2025 Mar;29(6):e70494
Identification of the Hub Gene LDB3 in Stanford Type A Aortic Dissection Based on Comprehensive Bioinformatics Analysis.
Liu X, Liu X, Wan B, Ge Y, Hu H, Yu H, Zhao M, Li H, Zhu J
Journal of cellular and molecular medicine 2025 Mar;29(6):e70471
Journal of cellular and molecular medicine 2025 Mar;29(6):e70471
p16INK4a Deletion Alleviated Obesity-Associated Kidney Fibrosis by Regulating Metabolic Reprogramming and the Inflammasome Pathway.
Liu Q, Wang F, Du Y, Liu Y, Zhang Z, Zhang X, Li J, Huang G, Liu F, Li B, Xiao W, Sui C, Bao N, Zhuang R, Gao C, Wang X, Gu X
Journal of cellular and molecular medicine 2025 Mar;29(5):e70444
Journal of cellular and molecular medicine 2025 Mar;29(5):e70444
Phenylethanol Glycosides from Cistanche tubulosa Modulate the Gut Microbiota and Cecal Metabolites to Ameliorate Diabetic Nephropathy Induced by Streptozotocin Combined with High-Fat Diet in Rats.
Ma C, Ju B, Liu J, Wen L, Zhao Y, Yang J, Hu J
Journal of medicinal food 2025 Mar;28(3):219-231
Journal of medicinal food 2025 Mar;28(3):219-231
Protective Effects of Lactoferrin Treatment Against Sodium Arsenite Exposure-Induced Nephrotoxicity.
Li S, Yin Y, Dong X, Xu L, Yang Z, Li H, Zou Y, Wu Z
Biological trace element research 2025 Mar;203(3):1539-1554
Biological trace element research 2025 Mar;203(3):1539-1554
Anti-fibrosis effect and its mechanism of atractylenolide III on post-traumatic extending knee joint contracture in rats.
Zhang BB, Xu L, Zhang QB, Wang Y, Chen C, Zhang JN, Rao XL, Zhu BJ, Li XM, Zhu DT, Kan XL, Mao J, Zhang R, Zhou Y
Experimental gerontology 2025 Mar;201:112708
Experimental gerontology 2025 Mar;201:112708
Renal tubular S100A7a impairs fatty acid oxidation and exacerbates renal fibrosis via both intracellular and extracellular pathway.
Sun P, Chen Q, Chen X, Zhou J, Long T, Ma Y, Zhou M, Hu Z, Tian J, Zhu F, Yang Z, Xie L, Wu Q, Nie J
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167656
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167656
Exosomes derived from fibroblasts in DFUs delay wound healing by delivering miR-93-5p to target macrophage ATG16L1.
Xu Z, Ni T, Zhang Q, Sun X, Zhao L, Lin J, Gao W, Yi M, Zhang L, Tu L, Wu G, Yan W
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167640
Biochimica et biophysica acta. Molecular basis of disease 2025 Mar;1871(3):167640
1-benzyl-6-nitro-4-phenyl-4-(methoxycarbonyl)-2(1H)-pyridinone, a novel pirfenidone derivative, alleviate hepatic fibrosis through T cells.
Hu MX, Li JQ, Zhang HW, Ma YK, Zhao BJ, Xiao L, Liang W, Wang Y, Wang C, Wu CG, Liu TT
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Mar;184:117907
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Mar;184:117907
The role of fibromodulin in myocardial fibrosis in a diabetic cardiomyopathy rat model.
Dai X, Yang F, Chen D, Yang L, Dong Z, Chen C, Xiao J
FEBS open bio 2025 Mar;15(3):436-446
FEBS open bio 2025 Mar;15(3):436-446
Enhanced Vascular Smooth Muscle Cell and Extracellular Matrix Repair Using a Metal-Organic Framework-Based Co-Delivery System for Abdominal Aortic Aneurysm Therapy.
Lei J, Dong X, Huang Y, Wu Z, Peng Z, Li B, Wang R, Pan Y, Zheng X, Zhao Z, Lu X
Advanced healthcare materials 2025 Mar;14(6):e2402937
Advanced healthcare materials 2025 Mar;14(6):e2402937
Puerarin mitigates cognitive decline and white matter injury via CD36-Mediated microglial phagocytosis in chronic cerebral hypoperfusion.
Luo Q, Li F, Liu X, Yan T, Yang L, Zhu W, Zheng H, Li Y, Tu J, Zhu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156396
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156396
Lgals3 Promotes Calcium Oxalate Crystal Formation and Kidney Injury Through Histone Lactylation-Mediated FGFR4 Activation.
Ye Z, Sun Y, Yang S, Li L, Li B, Xia Y, Yuan T, Yu W, Chen L, Zhou X, Cheng F
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2413937
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2413937
4-Octyl Itaconate Alleviates Myocardial Ischemia-Reperfusion Injury Through Promoting Angiogenesis via ERK Signaling Activation.
Yang J, Duan C, Wang P, Zhang S, Gao Y, Lu S, Ji Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2411554
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2411554
Mechanism of β-Catenin in Pulmonary Fibrosis Following SARS-CoV-2 Infection.
Jiang M, Hou J, Chai Q, Yin S, Liu Q
Cells 2025 Mar 7;14(6)
Cells 2025 Mar 7;14(6)
An annular corneal microneedle patch for minimally invasive ophthalmic drug delivery.
Wang L, Guo Y, Chen B, Lu S, Yang J, Jin Y, Wang X, Sun X, Wang S, Wang B
Science advances 2025 Mar 7;11(10):eadv1661
Science advances 2025 Mar 7;11(10):eadv1661
Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution.
Ciuba K, Piotrowska A, Chaudhury D, Dehingia B, Duński E, Behr R, Soroczyńska K, Czystowska-Kuźmicz M, Abbas M, Bulanda E, Gawlik-Zawiślak S, Pietrzak S, Figiel I, Włodarczyk J, Verkhratsky A, Niedbała M, Kaspera W, Wypych T, Wilczyński B, Pękowska A
Cell stem cell 2025 Mar 6;32(3):426-444.e14
Cell stem cell 2025 Mar 6;32(3):426-444.e14
Network pharmacology and molecular docking technology-based predictive study and potential targets analysis of icariin for the treatment of diabetic nephropathy.
Chen M, Zhou Y, Yang J, Yuan H
Biochemical and biophysical research communications 2025 Mar 5;751:151434
Biochemical and biophysical research communications 2025 Mar 5;751:151434
Reticulophagy promotes EMT-induced fibrosis in offspring's lung tissue after maternal exposure to carbon black nanoparticles during gestation by a m(5)C-dependent manner.
Du Z, Liu Q, Wang M, Gao Y, Li Q, Yang Y, Lu T, Bao L, Pang Y, Wang H, Niu Y, Zhang R
Journal of hazardous materials 2025 Mar 5;485:136873
Journal of hazardous materials 2025 Mar 5;485:136873
Inhibition of NLRP3 alleviates calcium oxalate crystal-induced renal fibrosis and crystal adhesion.
Xu Y, Li G, Liu W, Ge D, Hao Z, Wang W
Urolithiasis 2025 Mar 4;53(1):44
Urolithiasis 2025 Mar 4;53(1):44
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex.
Zhao C, Zhang T, Xue ST, Zhang P, Wang F, Li Y, Liu Y, Zhao L, Wu J, Yan Y, Mao X, Chen Y, Yuan J, Li Z, Li K
Cell metabolism 2025 Mar 4;37(3):692-707.e9
Cell metabolism 2025 Mar 4;37(3):692-707.e9
KLF5 enhances CXCL12 transcription in adipose-derived stem cells to promote endothelial progenitor cells neovascularization and accelerate diabetic wound healing.
Xie Y, Ni X, Wan X, Xu N, Chen L, Lin C, Zheng X, Cai B, Lin Q, Ke R, Huang T, Hu X, Wang B, Shan X
Cellular & molecular biology letters 2025 Mar 4;30(1):24
Cellular & molecular biology letters 2025 Mar 4;30(1):24
VHL ameliorates arecoline-induced oral submucosal fibrosis by promoting HDAC6 ubiquitination and blocking NF-κB pathway.
Sun H, Yang C, Yin X, Chen S, Huang Y, Kuang H, Luo W
Scientific reports 2025 Mar 4;15(1):7563
Scientific reports 2025 Mar 4;15(1):7563
Inhibition of HSC proliferation and hepatic fibrogenesis with Erythrocyte membrane coated Doxorubicin/Black phosphorus nanosheets.
Xiang L, Xiang X, Jiao Q, Luo Y, Zeng G, Zhang W, Qin Y, Chen Y
International journal of pharmaceutics 2025 Mar 30;673:125403
International journal of pharmaceutics 2025 Mar 30;673:125403
Butyrate Ameliorates Graves' Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota.
Ouyang P, Qi J, Tong B, Li Y, Cao J, Wang L, Niu T, Qi X
Investigative ophthalmology & visual science 2025 Mar 3;66(3):5
Investigative ophthalmology & visual science 2025 Mar 3;66(3):5
Cyanidin-3-glucoside upregulated NDRG2 through the PI3K/AKT pathway to alleviate EMT and ECM in renal fibrosis.
Lu Q, Liu J, Xiong Y, Jian J, Wang J, Chen Z, Wan S, Liu X, Wang L
Scientific reports 2025 Mar 28;15(1):10695
Scientific reports 2025 Mar 28;15(1):10695
Medium from human iPSC-derived primitive macrophages promotes adult cardiomyocyte proliferation and cardiac regeneration.
Xiao Y, Zhang H, Liu X, Xu P, Du H, Wang J, Shen J, Li Y, Wang Y, He C, Feng H, Liu J, Zhou Y, Liu S, Gao Z, Zang J, Bi J, Tang TS, Gu Q, Wei T, Wang J, Song M
Nature communications 2025 Mar 27;16(1):3012
Nature communications 2025 Mar 27;16(1):3012
Electroacupuncture Attenuates Intestinal Barrier Disruption via the α7nAChR-Mediated HO-1/p38 MAPK/NF-κB Pathway in a Mouse Model of Metabolic Dysfunction-Associated Fatty Liver Disease: A Randomized, Single-Blind, Controlled Trial.
Wang X, Sun J, Wang P, Zhang Y, Chang J, Duan Z
Biomedicines 2025 Mar 27;13(4)
Biomedicines 2025 Mar 27;13(4)
Colorectal cancer cells-derived exosomal miR-188-3p promotes liver metastasis by creating a pre-metastatic niche via activation of hepatic stellate cells.
Li T, Li T, Liang Y, Yuan Y, Liu Y, Yao Y, Lei X
Journal of translational medicine 2025 Mar 25;23(1):369
Journal of translational medicine 2025 Mar 25;23(1):369
Rare and common genetic variants underlying the risk of Hirschsprung's disease.
Xiao J, Feng C, Zhu T, Zhang X, Chen X, Li Z, You J, Wang Q, Zhuansun D, Meng X, Wang J, Xiang L, Yu X, Zhou B, Tang W, Tou J, Wang Y, Yang H, Yu L, Liu Y, Jiang X, Ren H, Yu M, Chen Q, Yin Q, Liu X, Xu Z, Wu D, Yu D, Wu X, Yang J, Xiong B, Chen F, Hao X, Feng J
Human molecular genetics 2025 Mar 20;34(7):586-598
Human molecular genetics 2025 Mar 20;34(7):586-598
Low intensity pulsed ultrasound alleviates synovial fibrosis in osteoarthritis via the PI3K/AKT pathway.
Liao Q, Chen J, Liu G
Scientific reports 2025 Mar 20;15(1):9644
Scientific reports 2025 Mar 20;15(1):9644
Vitamin A-Integrated Cinnamaldehyde Nanoemulsion: A Nanotherapeutic Approach To Counteract Liver Fibrosis via Gut-Liver Axis Modulation.
Niu X, Chang G, Xu N, Li R, Niu B, Mao R, Wang S, Li G, Jiang J, Wang L
ACS nano 2025 Mar 18;19(10):10433-10451
ACS nano 2025 Mar 18;19(10):10433-10451
Polo-like kinase2 regulates renal tubulointerstitial fibrosis via notch signaling pathway in diabetic kidney disease.
Luo J, Xu H, Su C, Dong W, Xiao M, Xiao N, Jia Y, Xue Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Mar 15;39(5):e70455
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Mar 15;39(5):e70455
TRPML1 ion channel promotes HepaRG cell differentiation under simulated microgravity conditions.
Fan H, Lü D, Lu Z, Li H, Qi Z, Sun S, Guan D, Long M, Gao M, Liu S
NPJ microgravity 2025 Mar 15;11(1):9
NPJ microgravity 2025 Mar 15;11(1):9
Silencing hepatic PCSK9 via novel chimeric AAV8 mitigates the progression of atherosclerosis by inhibiting inflammation in ApoE(-/-) mice.
Chen X, Sun M, Ma X, Ma Y, Chen B
Molecular therapy. Methods & clinical development 2025 Mar 13;33(1):101390
Molecular therapy. Methods & clinical development 2025 Mar 13;33(1):101390
Aerosolized nicotine-free e-liquid base constituents exacerbates mitochondrial dysfunction and endothelial glycocalyx shedding via the AKT/GSK3β-mPTP pathway in lung injury models.
Dai Z, Xie B, Jiang C, Peng Y, Lin J, Chen Q, Sun J
Respiratory research 2025 Mar 1;26(1):82
Respiratory research 2025 Mar 1;26(1):82
Baicalin reduced vandetanib induced myocardial injury by regulating redox balance and NLRP3 inflammasome pathway.
Wang F, Li J, Zhang Z, Huang G, Zhang X, Liu Q, Xiao W, Liu F, Sun J, Liu Y, Ma Y, Zhuang R, Du Y, Wang X, Gao C, Gu X
Tissue & cell 2025 Jun;94:102795
Tissue & cell 2025 Jun;94:102795
Beneficial effects of Akkermansia muciniphila on benign prostatic hyperplasia and metabolic syndrome.
Wu S, Yin X, Yang P, Gong B, Wang Z
Archives of biochemistry and biophysics 2025 Jun;768:110294
Archives of biochemistry and biophysics 2025 Jun;768:110294
Application of (68)Ga- and (177)Lu-Labeled FAP Inhibitor in Evaluation and Treatment of Cardiac Fibrosis After Myocardial Infarction.
Zhao Y, Su X, Xiang B, Zhang S, Zhou X
MedComm 2025 Jun;6(6):e70198
MedComm 2025 Jun;6(6):e70198
H3K18 lactylation-mediated SIX1 upregulation contributes to silica-induced epithelial-mesenchymal transition in airway epithelial cells.
Liu S, He Y, Jin L, Shi S, Zhang J, Xie W, Yang M, Zhang Q, Kong H
Toxicology 2025 Jun;514:154109
Toxicology 2025 Jun;514:154109
MTMR7 attenuates the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary hypertension by suppressing ERK/STAT3 signaling.
Wang J, Xuan B, Song B, Wang T, Lan C, Guo W, Yang Y, Sun X
Molecular and cellular biochemistry 2025 Jun;480(6):3799-3812
Molecular and cellular biochemistry 2025 Jun;480(6):3799-3812
Metformin Attenuates Partial Epithelial-Mesenchymal Transition in Salivary Gland Inflammation via PI3K/Akt/GSK3β/Snail Signaling Axis.
Peng B, Wang L, Pan S, Kang J, Wei L, Li B, Cheng Y
Inflammation 2025 Jun;48(3):1525-1537
Inflammation 2025 Jun;48(3):1525-1537
Neddylation of RhoA impairs its protein degradation and promotes renal interstitial fibrosis progression in diabetic nephropathy.
Li XQ, Jin B, Liu SX, Zhu Y, Li N, Zhang QY, Wan C, Feng Y, Xing YX, Ma KL, Liu J, Jiang CM, Lu J
Acta pharmacologica Sinica 2025 Jun;46(6):1692-1705
Acta pharmacologica Sinica 2025 Jun;46(6):1692-1705
A thermosensitive hydrogel with synergistic stromal targeting and antitumor immunity modulation for pancreatic cancer immunotherapy.
Zhao G, Guo F, Yan W, Qu Y, Yan C, Lv H, Li G, Zhao J, Xie H, Li Y, Tian T, Zhao Z
Materials today. Bio 2025 Jun;32:101882
Materials today. Bio 2025 Jun;32:101882
Shuangshi Tonglin Capsule Improves Prostate Fibrosis through Nrf2/TGF-β1 Signaling Pathways.
Wang ZQ, Mao P, Wang BA, Guo Q, Liu H, Yuan Y, Wang C, Liu JP, Zhu XM, Wei H
Chinese journal of integrative medicine 2025 Jun;31(6):518-528
Chinese journal of integrative medicine 2025 Jun;31(6):518-528
miR-145-enriched BMSCs-derived exosomes ameliorate neurogenic erectile dysfunction in aged rats via TGFBR2 inhibition.
Hong Y, Feng Z, Ge Y, Xi Y, Zhang B, Wu J, Xia T, Tang B, Wang W, Chen J, Wang H, Xiao H
Regenerative therapy 2025 Jun;29:455-465
Regenerative therapy 2025 Jun;29:455-465
Antitumour and anti-angiogenesis efficacy of a multifunctional self-oxygenated active-targeting drug delivery system by encapsulating biological and chemotherapeutic drugs.
Zhu M, Xie Y, Li Z, Bao H, Miao D, Guo X, Wang S, Chen K, Chen H, Dai J, Yang N, Yu L, Pei J
Colloids and surfaces. B, Biointerfaces 2025 Jun;250:114549
Colloids and surfaces. B, Biointerfaces 2025 Jun;250:114549
A Novel Nude Mice Model for Studying the Pathogenesis of Keloid.
Zhang Y, Bao Y, Li Z, Jin Z
Journal of cosmetic dermatology 2025 Jun;24(6):e70284
Journal of cosmetic dermatology 2025 Jun;24(6):e70284
Ultrasound-responsive taurine lipid nanoparticles attenuate oxidative stress and promote macrophage polarization for diabetic wound healing.
Luo Z, Zheng S, Hu Z, Li P, Zeng J, Lu Y, Ali M, Chen Z, Wang Q, Qi F
Free radical biology & medicine 2025 Jun;233:302-316
Free radical biology & medicine 2025 Jun;233:302-316
Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways.
Huang X, Kui X, Ma J, Chen J, Huang Y, He B
Mechanisms of ageing and development 2025 Jun;225:112067
Mechanisms of ageing and development 2025 Jun;225:112067
A telescopic microscope equipped with a quanta image sensor for live-cell bioluminescence imaging.
Ma R, Santino LM, Chobola T, Armbrust N, Geilenkeuser J, Sukumaran S, Jing Z, Levkina A, Ridderbeek K, Peng T, Truong DJ, Doll S, Westmeyer GG, Cui J
Nature methods 2025 Jun;22(6):1321-1330
Nature methods 2025 Jun;22(6):1321-1330
MBD2 promotes epithelial-to-mesenchymal transition (EMT) and ARDS-related pulmonary fibrosis by modulating FZD2.
Zhou Y, Yang G, Liu J, Yao S, Jia J, Tang X, Gong X, Wan F, Wu R, Zhao Z, Liang H, Liu L, Liu Q, Xie S, Long X, Xiang X, Wang G, Xiao B
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167798
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167798
PPAR-gamma agonist pioglitazone improves endometrial receptivity, reverses endometrial barrier disruption and promotes ovarian function in thin endometrium rats via modulation PPAR-γ/Wnt5/β-catenin pathway.
Li H, Guan Y, Chen X, Tian W, Xie J, Yang B
Journal of reproductive immunology 2025 Jun;169:104526
Journal of reproductive immunology 2025 Jun;169:104526
Phenotypic screening uncovered anti-myocardial fibrosis candidates using a novel 3D myocardial tissue under hypoxia.
Wang J, Liu X, Zhu R, Sun Y, Jiao B, Wang K, Jiang Y, Wang Y, Li C, Wang W
Acta pharmaceutica Sinica. B 2025 Jun;15(6):3008-3024
Acta pharmaceutica Sinica. B 2025 Jun;15(6):3008-3024
Diabetic wound healing breakthrough: theaflavin-3, 3'-digallate nanoparticles@hydrogel activates the TGF-β1/SMAD3 pathway.
Dong X, Miao J, Wu L, Kong Z, Liu Z, Jia D, Zhai Q, Zhang D, Xu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156617
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156617
Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury.
Du H, Liu X, Shen J, Yuan H, Zhang H, Xi G, Li Y, Wang Y, Zhang J, Yang C, Xu P, Wang J, Wang F, Liu S, Zhou Y, Gu Q, Lu J, Wei T, Gao Z, Zang J, Wang J, Song M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2417827
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2417827
GRK2-facilitated TLR4 signaling promotes cardiac fibrosis in rheumatic mice.
Wang Z, Chu R, Ge H, Zhu Z, Zhang R, Han D, Fang R, Wang N, Gao S, Wang Y, Han Y, Wang Q
International immunopharmacology 2025 Jun 5;157:114709
International immunopharmacology 2025 Jun 5;157:114709
TIMP1 regulation of cardiac fibroblast proliferation via the TGF-β/Smad pathway in an in vitro model of atrial fibrillation.
Zhou Y, Zhang L, Zhang W, Gong Q, Zhang Z, Xu N, Wilson-Smith AR, Chen N
Journal of thoracic disease 2025 Jun 30;17(6):4249-4263
Journal of thoracic disease 2025 Jun 30;17(6):4249-4263
Rebastinib attenuates acute lung injury by promoting NLRP3 ubiquitination and blocking NLRP3/GSDMD signaling pathway in macrophages and protecting alveolar epithelial cells.
Wang L, Chen H, Lu C, Ding Y, He Y, Xu J, Xu J, Zhang Z
International immunopharmacology 2025 Jun 26;159:114819
International immunopharmacology 2025 Jun 26;159:114819
Therapeutic potential of targeting the NEDD4L-eEF1A1 axis in cancer therapy.
Qin Y, Wang X, Zhao M, Liu Y, Hou H, Wang T, Pei Y, Zhang J, Shen Z, Wu F, Zheng L, Li J, Ni Z, Shi J
Acta biochimica et biophysica Sinica 2025 Jun 25;58(2):383-395
Acta biochimica et biophysica Sinica 2025 Jun 25;58(2):383-395
Macrophage extracellular traps as key mediators of scleral remodeling in myopia induced by hypoxia and activated platelets.
Feng Q, Yuan J, Hu Y, Feng C, Lin X, Liu S, Ji S, Mao X, Lin X, Cong J, Li X, Li X, Li H, Yan D, Dai J
Cell reports 2025 Jun 24;44(6):115771
Cell reports 2025 Jun 24;44(6):115771
Daidzein alleviates CCl(4)- and BDL-induced liver fibrosis via suppressing the integrin alphaVbeta1/YAP signaling.
Bai J, Yang Z, Wang P, Qian B, Jiang Z, Xu T, Pu H, Ye M, Du Y, Fu W
Food & function 2025 Jun 16;16(12):4822-4836
Food & function 2025 Jun 16;16(12):4822-4836
Carbon monoxide gas molecules: Therapeutic mechanisms in radiation-induced lung injury.
Li Y, Zhou B, Liu D, Nie G, Yang F, Chen J, Cheng S, Kang Y, Liu B, Dong B, Liu M
Journal of colloid and interface science 2025 Jun 15;688:250-263
Journal of colloid and interface science 2025 Jun 15;688:250-263
Activation of mechanosensitive ion channel Piezo1 linking metabolic reprogramming and pro-inflammatory responses in hepatocellular carcinoma.
Mo J, Zhang Y, Cao C, Zheng W, Zheng L, Wang X, Wang S, Wu J, Bao Y
Cell communication and signaling : CCS 2025 Jun 13;23(1):280
Cell communication and signaling : CCS 2025 Jun 13;23(1):280
Nobiletin from Citrus reticulata Blanco alleviates pulmonary fibrosis through inhibiting the PI3K/AKT pathway and epithelial-mesenchymal transition.
Yu S, Liu K, Zhou F, Yang X, Zhang J, Yu K, Zhu Y, Qin L, Peng T, Zhang C, He Y
Journal of ethnopharmacology 2025 Jun 12;349:119965
Journal of ethnopharmacology 2025 Jun 12;349:119965
Chemical compounds from Allii Tuberosi Semen exhibiting anti-fibrotic effects on hepatic stellate cells.
Zhao R, Liu X, Liu J, Wang H, Cui Y, Yu R, Jin T, Wang S, Qin X, Wang M, Ji L, Wang T, Jalsrai A, Cong Y
Journal of ethnopharmacology 2025 Jun 12;349:119949
Journal of ethnopharmacology 2025 Jun 12;349:119949
FOXO1 contributes to cigarette smoke condensate-induced cellular senescence and fibrosis in lung fibroblasts through activating the TGF-β1/Smad2/3 signaling pathway.
Zheng M, Yuan G, Han J, Li J, Jiang Y, Li Z, Yao Y
Immunologic research 2025 Jun 11;73(1):94
Immunologic research 2025 Jun 11;73(1):94
RGD peptide hydrogel downregulates mechanosignal YAP to inhibit postoperative scarring.
Lv Y, Liang L, Qin M, Jiang RP, Zong FF, Wu X, Wu KL, Liang L
Acta biomaterialia 2025 Jun 1;199:132-141
Acta biomaterialia 2025 Jun 1;199:132-141
Discovery of novel selective HDAC6 inhibitors via a scaffold hopping approach for the treatment of idiopathic pulmonary fibrosis (IPF) in vitro and in vivo.
Quan J, Ma C, Zhao X, Guo Y, Qu W, Zhou X, Ma E, Xu Y
Bioorganic chemistry 2025 Jun 1;159:108360
Bioorganic chemistry 2025 Jun 1;159:108360
Integrated transcriptomics and metabolomics unravel the key metabolic pathways involved in the therapeutic mechanism of Salvianic acid A against hepatic fibrosis.
Zhang Y, Zhang Y, Zhang J, Lai W, He G, Shi J, Zhang C, Xiong L, Wang T, Ye F, Jiang X
Toxicology and applied pharmacology 2025 Jul;500:117398
Toxicology and applied pharmacology 2025 Jul;500:117398
Sinomenine Ameliorates Liver Fibrosis by Blocking TGF-β/SMAD and c-JUN Signaling.
Du Y, Bai J, Ma T, Wu Z, Wang P, Zhong X, Fu W, He S
Phytotherapy research : PTR 2025 Jul;39(7):3182-3196
Phytotherapy research : PTR 2025 Jul;39(7):3182-3196
Methacrylated sericin/methacrylated hyaluronic acid composite microneedles with exosomes for diabetic wound healing.
Xu X, Shen Y, Wu J, Hong F, Xia H, Chen X, Lin G, Liu L, Xu RA
International journal of biological macromolecules 2025 Jul;318(Pt 1):144957
International journal of biological macromolecules 2025 Jul;318(Pt 1):144957
UCP1 prevents the formation of thoracic aortic aneurysms and dissection by inhibiting the TLR4/NLRP3/IL-1β signaling pathway and VSMC phenotype switching in mice.
Xiang J, Yue H, Jiang D, Zheng S, Wu Z
Biochemical pharmacology 2025 Jul;237:116929
Biochemical pharmacology 2025 Jul;237:116929
A-485 alleviates fibrosis and apoptosis in kidney by disrupting tandem activation of acetylation and phosphorylation on STAT3.
Du C, Zhu Y, Duan J, Yang Y, Ren Y, Mu L, Yan Z, Li G, Wang H, Shi Y, Yao F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jul;188:118217
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jul;188:118217
The KSR1/MEK/ERK signaling pathway promotes the progression of intrauterine adhesions.
Wu S, Chen Q, Yang X, Zhang L, Huang X, Huang J, Wu J, Sun C, Zhang W, Wang J
Cellular signalling 2025 Jul;131:111730
Cellular signalling 2025 Jul;131:111730
Fucoxanthin Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Mice via Nrf2/HO-1/GPX4-Mediated Ferroptosis Pathway.
Liu Z, Ye J, Xi J, Li Q, Tang Y, Tian Y, Wang D, Yang Z, Ding Y
Food science & nutrition 2025 Jul;13(7):e70589
Food science & nutrition 2025 Jul;13(7):e70589
Inhibition of RACK1-Mediated NLRP3 Oligomerization (Active Conformation) Ameliorates Acute Respiratory Distress Syndrome.
Cui J, Yang M, Yu C, Zhang H, Gong Y, Hu Y, Wang Y, Yuan Q, Pan A, Li J, Hu Y, Jin Z, Peng X, Wu A, Wang J, Wang Q, Zhang Y, Hu L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(27):e2411355
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(27):e2411355
Tβ4-Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing.
Ding Y, Wang J, Li J, Cheng Y, Zhou S, Zhang Y, Zhao Y, Zhou M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2505009
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2505009
Calpain-2-Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection.
Teng X, Wang Y, Huang H, Ding Y, Wang J, Liu M, Song K, Shao L, Yu Y, Yang Z, Shen Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2501112
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2501112
Ubiquitin Specific Protease 9X Regulates the Activation of ARK5 and Promotes Progression of Fibrotic Remodeling.
Li X, Jiang S, Yang W, Zhu X, Zhang F, Li Z, Guo X, Wei Y
JACC. Basic to translational science 2025 Jul;10(7):101255
JACC. Basic to translational science 2025 Jul;10(7):101255
Dermal papilla cells-conditioned medium attenuates oxidative stress-induced senescence via ferroptosis inhibition.
Ru Z, Wu Y, Qu Q, Miao Y, Zhu L, Hu Z
Scientific reports 2025 Jul 9;15(1):24789
Scientific reports 2025 Jul 9;15(1):24789
Xiaoyu Xiezhuo Decoction Ameliorates Tubulointerstitial Fibrosis by Modulating Gut-Kidney Axis and Aldosterone Signaling Pathway in UUO Rats.
Sun K, Huang F, Xie W, Hu W, Zhu M, Fan Z, Lu K
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 31;39(14):e70861
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 31;39(14):e70861
Disintegrin Rhodostomin Mutant Ameliorates the Severity of Experimental Proliferative Vitreoretinopathy by Suppressing Both Integrin αvβ3 and α5β1.
Tsao YC, Chen SH, Ou YC, Chuang WJ, Yang CH, Lin CJ, Hsu SM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 31;39(14):e70844
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 31;39(14):e70844
Hypoxia Induces HIF-1α Activation in Tendon Stem Cells to Enhance Extracellular Vesicle-Mediated Tendon Repair.
Wu Y, Zhang T, Miao Y, Zhang A, Wang S, Li X, Liu H, Guo Y, Sun Q, Li Z
ACS applied materials & interfaces 2025 Jul 30;17(30):42637-42657
ACS applied materials & interfaces 2025 Jul 30;17(30):42637-42657
Pantothenic acid ameliorates hepatic fibrosis by targeting IGFBP6 to regulate the TGF-β/SMADs pathway.
Jin Z, Jin Z, Liu Z, Yin Y, Zhang Y, Zhang Y, Kang J, Fang Y, Jiang W, Ning B
Communications biology 2025 Jul 29;8(1):1127
Communications biology 2025 Jul 29;8(1):1127
Salvianolic Acid B Attenuates Liver Fibrosis via Suppression of Glycolysis-Dependent m1 Macrophage Polarization.
Song H, Li ZW, Xu W, Tan Y, Kuang M, Pei G, Wang ZQ
Current issues in molecular biology 2025 Jul 29;47(8)
Current issues in molecular biology 2025 Jul 29;47(8)
FBP1 as a key regulator of focal adhesion kinase-mediated hepatic stellate cell activation: Multi-omics and experimental validation.
Wu HY, Han L, Ran T, Sun Y, Zhang QX, Huang T, Zou GL, Zhang Y, Zhou YM, Lin GY, Chen SJ, Wang JL, Pan C, Lu F, Pu HF, Zhao XK
World journal of gastroenterology 2025 Jul 28;31(28):107361
World journal of gastroenterology 2025 Jul 28;31(28):107361
Wikstdaphnoids A-I, Daphnane Diterpenoid Orthoesters from Wikstroemia chamaedaphne with Anti-Liver Fibrosis Activity.
Huang D, Liao YL, Chen JQ, Yuan FY, Wu SQ, Huang JL, Yuan T, Chen X, Sun ZH, Tang GH, Gan L, Yin S
Journal of natural products 2025 Jul 25;88(7):1781-1790
Journal of natural products 2025 Jul 25;88(7):1781-1790
Identifying fibroblast-derived sFRP2 as a therapeutic target and engineering siRNA therapy for uterine scarring.
Cheng J, Zhang S, Gui Q, Pu Z, Chen Z, Wei Q, Qi H, Zhang J
Nature communications 2025 Jul 25;16(1):6850
Nature communications 2025 Jul 25;16(1):6850
Gluconic acid alleviates hypertrophic scar formation through binding PLOD1, reducing p-AKT signaling and activating autophagy.
Li J, Zeng S, Sun Y, Zou J, Zhang E, Yan Q, Chen L, Li J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156825
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156825
Mechanistic exploration of Dahuang Zhechong Pill against hepatic fibrosis via integrated serum pharmacochemistry, UHPLC-ESI-QTOF-MS/MS, network pharmacology, and molecular docking with cellular and zebrafish validation.
Li M, Deng K, Li Y, Xiang L, Wang Y, Shi H, Kuang S, Wen J, Zhou C, Lv Z, Huang S
Journal of ethnopharmacology 2025 Jul 24;351:120102
Journal of ethnopharmacology 2025 Jul 24;351:120102
Bioactive fraction of processed Curcumae Rhizoma-Sparganii Rhizoma anti-liver fibrosis by regulate taurine metabolism through PI3K/AKT pathway.
Hao M, Chen Z, Wang P, Lu Y, An D, Yang Q, Han X, Wang K, Sang X, Cao G
Journal of ethnopharmacology 2025 Jul 24;351:120090
Journal of ethnopharmacology 2025 Jul 24;351:120090
ATG7-deficient fibroblast promotes breast cancer progression via exosome-mediated downregulation of SCARB1.
Li K, Liu T, Luo Z, Yu Y, Liu Y, Zhang Z, Li W
Cell death & disease 2025 Jul 24;16(1):556
Cell death & disease 2025 Jul 24;16(1):556
Ameliorating Myocardial Infarction by Concurrent Pyroptosis Suppression and On-Demand Oxygen Production via Functionalized Nanocarrier.
Zhu W, Lu Y, Zong B, Chen Z, Ma Y, Wang H, Cao P, Han B
ACS applied materials & interfaces 2025 Jul 23;17(29):41626-41636
ACS applied materials & interfaces 2025 Jul 23;17(29):41626-41636
Astragalin promotes HSCs ferroptosis through NCOA4 mediated ferritinophagy to alleviate liver fibrosis in zebrafish and mice.
Wang Y, Kuang S, Li K, Chen S, Yang M, Deng K, Li M, Xie S, Chen Q, Wen J, Zhou C, Cheng W, Huang S, Lv Z
Communications biology 2025 Jul 21;8(1):1081
Communications biology 2025 Jul 21;8(1):1081
High-Fat Diet-Induced Diabetic Cardiomyopathy in Female Zebrafish: Cardiac Pathology and Functional Decline Mediated by Type 2 Diabetes.
Huang S, Chen Z, Li H, Zou Y, Wang B, Zhao W, Zheng L, Zhou Z, Peng X, Tang C
Nutrients 2025 Jul 2;17(13)
Nutrients 2025 Jul 2;17(13)
Integrated analyses to explore the mechanism of Gancao Renshen Zhixue Decoction in treating liver cirrhosis.
Pan J
Scientific reports 2025 Jul 2;15(1):23496
Scientific reports 2025 Jul 2;15(1):23496
Single-cell RNA sequencing in human atherosclerotic plaques reveals a novel smooth muscle cell subtype that possesses multi differentiation potential and shapes the microenvironment.
Ye W, Chen Z, Xia Z, Li D
Clinical and experimental medicine 2025 Jul 16;25(1):251
Clinical and experimental medicine 2025 Jul 16;25(1):251
CXCL12-targeting siRNA nanoparticles alleviate immunosuppression and inhibit tumor progression in esophageal squamous cell carcinoma.
Zhang S, Jiang H, Zhao C, Lei Y, Liu S, Xu C, Chen X, Zheng D, Wu X, Lin X, Chen W, Chen Y, Huang J, Wei X, Huang Y, Lin C
Journal of nanobiotechnology 2025 Jul 16;23(1):519
Journal of nanobiotechnology 2025 Jul 16;23(1):519
Exploring PU.1 as a Therapeutic Target to Mitigate Oxidative Stress and Inflammation in Peritoneal Dialysis-Induced Peritoneal Fibrosis.
Zhong S, Su W, Wang Y, Liu D, Li X, Ma F, Xu L, Gao J, Wang H, Sun J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70766
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70766
Mitochondrial Calcium Uniporter-Mediated Regulation of the SIRT3/GSK3β/β-Catenin Signaling Pathway in Vascular Remodeling.
Jiang M, Lin L, Yue S, Shi S, Yan H, Yi H, Han F, Xu S, Su J, Zhang R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70761
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70761
Pan-cancer human brain metastases atlas at single-cell resolution.
Xing X, Zhong J, Biermann J, Duan H, Zhang X, Shi Y, Gao Y, He K, Zhai D, Luo F, Lai Y, Xiao F, Wang W, Wang M, Xu J, Liu H, Tang J, Chu L, Chen T, D'Souza EK, Caprio L, Ebel L, Biswas D, Cottarelli A, Mou Y, Izar B, Zhang N, Bai F
Cancer cell 2025 Jul 14;43(7):1242-1260.e9
Cancer cell 2025 Jul 14;43(7):1242-1260.e9
Characterizing the Impact of Fabrication Methods on Mechanically Tunable Gelatin Hydrogels for Cardiac Fibrosis Studies.
Folh J, Tran PLD, Horton RE
Bioengineering (Basel, Switzerland) 2025 Jul 13;12(7)
Bioengineering (Basel, Switzerland) 2025 Jul 13;12(7)
Alleviation of fibrosis and oxidative stress in pressure overload-induced cardiac remodeling and heart failure via SIRT3 activation by colchicine.
Wu M, Chen G, Peng Y, Luo S
Biochemical and biophysical research communications 2025 Jul 12;770:151957
Biochemical and biophysical research communications 2025 Jul 12;770:151957
Kaempferol Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice by Regulating Intestinal Short-Chain Fatty Acids.
Zhang S, Tang F, Zhou Z, Li L, Tang Y, Fu K, Tan Y, Li L
International journal of molecular sciences 2025 Jul 11;26(14)
International journal of molecular sciences 2025 Jul 11;26(14)
Nonylphenol exposure induces myocardial fibrosis via the RhoA/ROCK1/MLC-signaling pathway.
Zheng M, Li S, Xu J, Luo Y, He J, Wang C, Xu Y, Zeng Y, Yu J
Ecotoxicology and environmental safety 2025 Jul 1;299:118423
Ecotoxicology and environmental safety 2025 Jul 1;299:118423
Autoimmune regulator deficiency causes sterile epididymitis and impacts male fertility through disruption of inorganic physiology.
Ahn SH, Halgren K, Grzesiak G, MacRenaris KW, Sue A, Xie H, Demireva E, O'Halloran TV, Petroff MG
Journal of immunology (Baltimore, Md. : 1950) 2025 Jul 1;214(7):1504-1516
Journal of immunology (Baltimore, Md. : 1950) 2025 Jul 1;214(7):1504-1516
Sintilimab and anlotinib with gemcitabine plus cisplatin in advanced biliary tract cancer: SAGC a randomized phase 2 trial.
Li J, Zhou S, Xu X, Zheng Q, Zhang F, Luo C, Li D, Sun X, Han Z, Wu W, Yan J, Shao Y, Zhang Y, Wu B, Wei Q, Wang X, Zhou Y, Sun W, Xu Q, Ying J
Nature communications 2025 Jul 1;16(1):5559
Nature communications 2025 Jul 1;16(1):5559
Comparison of the effects of Liraglutide, Tirzepatide, and Retatrutide on diabetic kidney disease in db/db mice.
Ma J, Hu X, Zhang W, Tao M, Wang M, Lu W
Endocrine 2025 Jan;87(1):159-169
Endocrine 2025 Jan;87(1):159-169
Network pharmacology, molecular docking, and experimental verification to reveal the mechanism of colquhounia root tablet in the treatment of diabetic nephropathy.
Chen D, Wang S, Sun Z, Zhang X, Chong N, Shu J, Wang Q, Xu Y
Biochemical and biophysical research communications 2025 Jan;745:151086
Biochemical and biophysical research communications 2025 Jan;745:151086
Slit2 Promotes H(2)O(2)-Induced Lens Epithelial Cells Oxidative Damage and Age-Related Cataract.
Fu L, Yang Q, Han Y, Sun F, Jin J, Wang J
Current eye research 2025 Jan;50(1):41-50
Current eye research 2025 Jan;50(1):41-50
Shionone Inhibits Glomerular Fibirosis by Suppressing NLRP3 Related Inflammasome though SESN2-NRF2/ HO-1 Pathway.
Xiao T, Zhao H, Wang Y, Chen M, Wang C, Qiao C
Diabetes & metabolism journal 2025 Jan;49(1):34-48
Diabetes & metabolism journal 2025 Jan;49(1):34-48
USP11 promotes renal tubular cell pyroptosis and fibrosis in UUO mice via inhibiting KLF4 ubiquitin degradation.
Wang X, Xie X, Ni JY, Li JY, Sun XA, Xie HY, Yang NH, Guo HJ, Lu L, Ning M, Zhou L, Liu J, Xu C, Zhang W, Wen Y, Shen Q, Xu H, Lu LM
Acta pharmacologica Sinica 2025 Jan;46(1):159-170
Acta pharmacologica Sinica 2025 Jan;46(1):159-170
NOTCH3 Mutation Causes Glymphatic Impairment and Promotes Brain Senescence in CADASIL.
Li C, Li H, Men X, Wang Y, Kang X, Hu M, Su X, Wang S, Lu D, Shen S, Huang H, Deng X, Liu Y, Zhang L, Cai W, Wu A, Lu Z
CNS neuroscience & therapeutics 2025 Jan;31(1):e70140
CNS neuroscience & therapeutics 2025 Jan;31(1):e70140
Identification the Cellular Senescence Associated lncRNA LINC01579 in Gastric Cancer.
He J, Fu Z, Zou B, Lei X, Lei L, Yang Q, Li G
Journal of cellular and molecular medicine 2025 Jan;29(2):e70360
Journal of cellular and molecular medicine 2025 Jan;29(2):e70360
Renal Tubular Epithelial Cell-Derived hsa_circ_0008925 From Urine Is Related to Chronic Renal Fibrosis.
Shi Y, Chen Y, Xiao Z, Wang Y, Fu C, Cao Y
Journal of cellular and molecular medicine 2025 Jan;29(1):e70335
Journal of cellular and molecular medicine 2025 Jan;29(1):e70335
A polysaccharide from Glycyrrhiza uralensis attenuates myocardial fibrosis via modulating the MAPK/PI3K/AKT signaling pathway.
Niu P, Zhang X, Zhang G, Jing R, Qiao Y, Zhou X, Bai M, Peng L
International journal of biological macromolecules 2025 Jan;286:138207
International journal of biological macromolecules 2025 Jan;286:138207
Enhancing epithelial regeneration with gelatin methacryloyl hydrogel loaded with extracellular vesicles derived from adipose mesenchymal stem cells for decellularized tracheal patching.
Lu Y, Shan Y, Zhu J, Shen Z, Chen W, Chen H, Shi H
International journal of biological macromolecules 2025 Jan;284(Pt 1):137927
International journal of biological macromolecules 2025 Jan;284(Pt 1):137927
A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2.
Gan L, Jiang Q, Huang D, Wu X, Zhu X, Wang L, Xie W, Huang J, Fan R, Jing Y, Tang G, Li XD, Guo J, Yin S
Nature chemical biology 2025 Jan;21(1):80-90
Nature chemical biology 2025 Jan;21(1):80-90
Increased NPM1 inhibit ferroptosis and aggravate renal fibrosis via Nrf2 pathway in chronic kidney disease.
Fu W, Zhang M, Meng Y, Wang J, Sun L
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167551
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167551
Research on the anti-hepatic fibrosis effects and active components of the medicinal plant Tithonia diversifolia.
Wang J, Li H, Wang T, Xie H, Ruan Y, Zhang C
Fitoterapia 2025 Jan;180:106317
Fitoterapia 2025 Jan;180:106317
Design, synthesis, and biological evaluation of novel 3-naphthylthiophene derivatives as potent SIRT2 inhibitors for the treatment of myocardial fibrosis.
Zhang Z, Ma C, Gao X, Wang C, Li Y, Yang C, Ma E, Cheng M
Bioorganic chemistry 2025 Jan;154:108033
Bioorganic chemistry 2025 Jan;154:108033
Multi-omics analysis reveals the protective effects of Chinese yam polysaccharide against cisplatin-induced renal interstitial fibrosis.
Wei M, Chen S, Huang Z, Zhang P, Yang Y, Chen S, Wan P, Huang Z, Chen X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156200
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156200
Circ-ECH1 May Compete With miR-708-5p to Regulate Ntrk2 in Bronchopulmonary Dysplasia.
Cheng H, Li D, Tang Y, Hu T, Wu B
Journal of cellular biochemistry 2025 Jan;126(1):e30678
Journal of cellular biochemistry 2025 Jan;126(1):e30678
Macrophages overexpressing interleukin-10 target and prevent atherosclerosis: Regression of plaque formation and reduction in necrotic core.
Wang M, Zhou S, Hu Y, Tong W, Zhou H, Ma M, Cai X, Zhang Z, Zhang L, Chen Y
Bioengineering & translational medicine 2025 Jan;10(1):e10717
Bioengineering & translational medicine 2025 Jan;10(1):e10717
Knockdown of AMFR Alleviates Atrial Fibrosis in Atrial Fibrillation by Stabilizing SOD1 Protein Expression.
Geng S, Ruan Z, Ying L, Liu Z
Journal of cardiovascular pharmacology and therapeutics 2025 Jan-Dec;30:10742484251356140
Journal of cardiovascular pharmacology and therapeutics 2025 Jan-Dec;30:10742484251356140
Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection: A natural ingredient strategy.
Zhou X, Ma D, He YX, Jin J, Wang HL, Wang YF, Yang F, Liu JQ, Chen J, Li Z
World journal of gastroenterology 2025 Jan 7;31(1):98561
World journal of gastroenterology 2025 Jan 7;31(1):98561
Estrogen Receptor β Activation Mitigates Colitis-associated Intestinal Fibrosis via Inhibition of TGF-β/Smad and TLR4/MyD88/NF-κB Signaling Pathways.
Ling F, Chen Y, Li J, Xu M, Song G, Tu L, Wang H, Li S, Zhu L
Inflammatory bowel diseases 2025 Jan 6;31(1):11-27
Inflammatory bowel diseases 2025 Jan 6;31(1):11-27
Cromolyn sodium reduces LPS-induced pulmonary fibrosis by inhibiting the EMT process enhanced by MC-derived IL-13.
Tan C, Zhou H, Xiong Q, Xian X, Liu Q, Zhang Z, Xu J, Yao H
Respiratory research 2025 Jan 6;26(1):3
Respiratory research 2025 Jan 6;26(1):3
Senolytic procyanidin C1 alleviates renal fibrosis by promoting apoptosis of senescent renal tubular epithelial cells.
Gan Y, Wang K, Chen X, Li Y, He Y, Zhou Y, Zhang B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jan 31;39(2):e70362
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jan 31;39(2):e70362
Pharmacological effects and mechanisms of danlong oral liquid in asthma airway remodeling: Insights from serum medicinal chemistry, network pharmacology, and experimental validation.
Liu B, Xiang M, Zhou M, Li C, Xin H, Zhang S, Lin J
Journal of ethnopharmacology 2025 Jan 31;340:119259
Journal of ethnopharmacology 2025 Jan 31;340:119259
Baricitinib represses the myocardial fibrosis via blocking JAK/STAT and TGF-β1 pathways in vivo and in vitro.
Feng R, Liu H, Chen Y
BMC cardiovascular disorders 2025 Jan 31;25(1):65
BMC cardiovascular disorders 2025 Jan 31;25(1):65
Lemon-derived nanoparticle-functionalized hydrogels regulate macrophage reprogramming to promote diabetic wound healing.
Jin E, Yang Y, Cong S, Chen D, Chen R, Zhang J, Hu Y, Chen W
Journal of nanobiotechnology 2025 Jan 31;23(1):68
Journal of nanobiotechnology 2025 Jan 31;23(1):68
Qianyang Yuyin granules alleviate hypertension-induced vascular remodeling by inhibiting the phenotypic switch of vascular smooth muscle cells.
Fan Y, Jialiken D, Zheng Z, Zhang W, Zhang S, Zheng Y, Sun Z, Zhang H, Yan X, Liu M, Fang Z
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118896
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118896
Comparison of chemical composition between imitation wild and transplanted Astragali Radix and their therapeutic effects on heart failure.
Zhang C, Zhu Y, Wang M, Chen R, Sun X
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118827
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118827
Atractylenolide-III restrains cardiac fibrosis after myocardial infarction via suppression of the RhoA/ROCK1 and ERK1/2 pathway.
Li X, Zhu X, Jiang S, Yang W, Zhang F, Guo X, Wei Y
International immunopharmacology 2025 Jan 3;145:113825
International immunopharmacology 2025 Jan 3;145:113825
Ginsenoside Rd protects against acute liver injury by regulating the autophagy NLRP3 inflammasome pathway.
Zhong X, Sun Y, Lin Y, Deng S, Wang H, Zhou X, Lu J, Zheng Y, Luo R, Huang M, Song J
Scientific reports 2025 Jan 28;15(1):3569
Scientific reports 2025 Jan 28;15(1):3569
UHRF1 promotes epithelial-mesenchymal transition mediating renal fibrosis by activating the TGF-β/SMAD signaling pathway.
Yang L, Si P, Kuerban T, Guo L, Zhan S, Zuhaer Y, Zuo Y, Lu P, Bai X, Liu T
Scientific reports 2025 Jan 27;15(1):3346
Scientific reports 2025 Jan 27;15(1):3346
Immunopathological characteristics and therapeutic effects of UC-MSCs in a pigeon breeder's lung mouse model.
Xu J, Li L, Zhou Y, Abudureheman Z, Xue L, Wu C, Zou X
Acta biochimica et biophysica Sinica 2025 Jan 21;57(3):473-485
Acta biochimica et biophysica Sinica 2025 Jan 21;57(3):473-485
Polystyrene microplastics induce liver fibrosis and lipid deposition in mice through three hub genes revealed by the RNA-seq.
Li Q, Zhu K, Huang L, Niu X, Li L, Gao L, Xia Z
Scientific reports 2025 Jan 20;15(1):2583
Scientific reports 2025 Jan 20;15(1):2583
Engineering spatially-confined conduits to tune nerve self-organization and allodynic responses via YAP-mediated mechanotransduction.
Luo X, Yang J, Zhao Y, Nagayasu T, Chen J, Hu P, He Z, Li Z, Wu J, Zhao Z, Duan G, Sun X, Zhao L, Pan Y, Wang X
Nature communications 2025 Jan 2;16(1):66
Nature communications 2025 Jan 2;16(1):66
Prolonged tamoxifen treatment induces iron deposition and ferroptosis in the liver.
Yang J, Wang D, Wang W, Wu C, Li C, Shi W, Qian J, Xie F, Shen H, Tang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jan 15;39(1):e70313
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jan 15;39(1):e70313
Protective effects of Notoginsenoside R2 on reducing lipid accumulation and mitochondrial dysfunction in diabetic nephropathy through regulation of c-Src.
Guo X, Yang L, An X, Hu M, Shen Y, Wang N, Xu Y, Gui D
Chinese medicine 2025 Jan 15;20(1):10
Chinese medicine 2025 Jan 15;20(1):10
Autoimmune regulator deficiency causes sterile epididymitis and impacts male fertility through disruption of inorganic physiology.
Ahn SH, Halgren K, Grzesiak G, MacRenaris KW, Sue A, Xie H, Demireva E, O'Halloran TV, Petroff MG
bioRxiv : the preprint server for biology 2025 Jan 15;
bioRxiv : the preprint server for biology 2025 Jan 15;
Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice.
Yin W, Xu H, Bai Z, Wu Y, Zhang Y, Liu R, Wang Z, Zhang B, Shen J, Zhang H, Chen X, Ma D, Shi X, Yan L, Zhang C, Jiang H, Chen K, Guo D, Niu W, Yin H, Zhang WJ, Luo C, Xie X
Nature communications 2025 Jan 11;16(1):598
Nature communications 2025 Jan 11;16(1):598
Wenshen Xiaozheng Tang alleviates fibrosis in endometriosis by regulating differentiation and paracrine signaling of endometrium-derived mesenchymal stem cells.
Zhang Z, Zhou X, Xia L, Li N, Xu S, Dong X, Zhu L, Huang M, Wan G
Journal of ethnopharmacology 2025 Jan 10;336:118724
Journal of ethnopharmacology 2025 Jan 10;336:118724
Cancer-associated fibroblasts induce almonertinib resistance in non-small cell lung cancer.
Wei G, Nie Y, Sun M, Zhou W, Zhao H, Chen F, Zhu C
Journal of translational medicine 2025 Jan 10;23(1):42
Journal of translational medicine 2025 Jan 10;23(1):42
Exosomes derived from TREM-2 knocked-out macrophages alleviated renal fibrosis via HSPa1b/AKT pathway.
Xiao Z, Wang Y, Chen Y, Jin L, Shi Y, Liu C, Fu C, Cao Y
American journal of physiology. Renal physiology 2025 Jan 1;328(1):F131-F151
American journal of physiology. Renal physiology 2025 Jan 1;328(1):F131-F151
Anisodamine ameliorates crystalline silica-exposed pulmonary inflammation and fibrosis via the α7nAChR/JAK2/STAT3 signaling pathway.
Liu M, Liu H, Kang H, Wu J, Xing P, Ding X, Wei Y, Kong X
Ecotoxicology and environmental safety 2025 Jan 1;289:117534
Ecotoxicology and environmental safety 2025 Jan 1;289:117534
Bleomycin pollution and lung health: The therapeutic potential of peimine in bleomycin-induced pulmonary fibrosis by inhibiting glycolysis.
Li K, Liu X, Lu R, Zhao P, Tian Y, Li J
Ecotoxicology and environmental safety 2025 Jan 1;289:117451
Ecotoxicology and environmental safety 2025 Jan 1;289:117451
Integrating Network Pharmacology and In Vitro Experimental Verification Revealing Bushenhuoxue Recipe Against Intrauterine Adhesions via PI3K-AKT Signaling Pathway.
Wang L, Zhuang L, Lu Y, Jia J, Chen C, Zhang Y, Hong Z, Wang X
Biochemical genetics 2025 Feb;63(1):686-697
Biochemical genetics 2025 Feb;63(1):686-697
Nicotinamide N-methyltransferase negatively regulates metastasis-promoting property of cancer-associated fibroblasts in lung adenocarcinoma.
Wang P, Wang G, Li H, Yuan Y, Chen H, Wang S, Sun Z, Meng F, Li Y, Yang F, Wang J, Chen K, Qiu M
Cancer communications (London, England) 2025 Feb;45(2):110-137
Cancer communications (London, England) 2025 Feb;45(2):110-137
The effect of tocilizumab treatment for skin fibrosis by inhibiting CD38(+) macrophages in systemic sclerosis.
Chen H, Yang D, Shi Y, Wu H, Zhu H, Jiang T, Liu S, Wang D
Cellular immunology 2025 Feb;408:104914
Cellular immunology 2025 Feb;408:104914
Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosis.
Su M, Zhao W, Jiang H, Zhao Y, Liao Z, Liu Z, Xu M, Jiang S, Wu L, Yang Y, Wang Z, Zeng Z, Fang Y, Tang C, Miller CL, Evans PC, Wang L, Banach M, Jo H, Berk BC, Offermanns S, Huang Y, Ge J, Xu S, Weng J
Nature cardiovascular research 2025 Feb;4(2):145-162
Nature cardiovascular research 2025 Feb;4(2):145-162
Pharmacokinetics Integrated With Network Pharmacology to Investigate the Potential Mechanism of Lu-Jiao Fang Inhibited Endothelial-to-Mesenchymal Transition in Pressure Overload-Induced Cardiac Fibrosis.
Shi X, Ma J, Liu W, Shen J, Xu G, Zhang J, Liu L
Biomedical chromatography : BMC 2025 Feb;39(2):e6075
Biomedical chromatography : BMC 2025 Feb;39(2):e6075
Novel full-thickness biomimetic corneal model for studying pathogenesis and treatment of diabetic keratopathy.
Cui Z, Li X, Ou Y, Sun X, Gu J, Ding C, Yu Z, Guo Y, Liang Y, Mao S, Ma JH, Chan HF, Tang S, Chen J
Materials today. Bio 2025 Feb;30:101409
Materials today. Bio 2025 Feb;30:101409
Negative air ions alleviate nicotine-induced renal damage of spontaneously hypertensive rats via inhibiting oxidative stress and TGF-β/Smad pathway.
Xiao S, Wei T, Xiao M, An Z, Shan M, Luo Z, Zhou J, Li N, Lu X
Ecotoxicology and environmental safety 2025 Feb;291:117882
Ecotoxicology and environmental safety 2025 Feb;291:117882
Integrated UHPLC-Q-exactive orbitrap HRMS and serum pharmacochemistry for the investigation of anti-hepatic fibrosis effect of Baoganning Decoction.
Deng K, Li M, Xiang L, Wang Y, Li Y, Wen J, Li Y, Kuang S, Wen J, Zhou C, Huang S, Lv Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156363
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Feb;137:156363
Curcumol ameliorates alcohol and high-fat diet-induced fatty liver disease via modulation of the Ceruloplasmin/iron overload/mtDNA signaling pathway.
Ding T, Shen W, Tao W, Peng J, Pan M, Qi X, Feng W, Wei N, Zheng S, Jin H
The Journal of nutritional biochemistry 2025 Feb;136:109807
The Journal of nutritional biochemistry 2025 Feb;136:109807
CB-MNCs@ CS/HEC/GP promote wound healing in aged murine pressure ulcer model.
Yang ZC, Lin H, Liu GJ, Pan H, Zhu JL, Zhang XH, Gao F, Wang Z, Wang ZH
Stem cell research & therapy 2025 Feb 7;16(1):52
Stem cell research & therapy 2025 Feb 7;16(1):52
Metal-organic framework-based nanoplatforms for synergistic anti-atherosclerosis therapy by regulating the PI3K/AKT/MSR1 pathway in macrophages.
Zeng C, Peng Z, Huang S, Xu Z, Peng Z, Wu Z, Lei J, Zhang X, Qin J, Ye K, Li B, Zhao Z, Pan Y, Yin M, Lu X
Nanoscale 2025 Feb 6;17(6):3071-3085
Nanoscale 2025 Feb 6;17(6):3071-3085
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis.
Huo JL, Fu W, Feng Q, Pan S, Liu D, Liu Z
Clinical science (London, England : 1979) 2025 Feb 6;139(3):229-46
Clinical science (London, England : 1979) 2025 Feb 6;139(3):229-46
MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy.
Liang J, Zhao J, Yang L, Wang Q, Liao J, Li J, Zhuang W, Li F, He J, Tang Y, Chen H, Huang C
Stem cell research & therapy 2025 Feb 4;16(1):40
Stem cell research & therapy 2025 Feb 4;16(1):40
Cloned airway basal progenitor cells to repair fibrotic lung through re-epithelialization.
Zhao Y, Zhou Y, Zhang W, Liu M, Duan J, Zhang X, Ma Q, Wang Y, Zhang Y, Guo Z, Zhang T, Zuo W
Nature communications 2025 Feb 3;16(1):1303
Nature communications 2025 Feb 3;16(1):1303
Dedifferentiated fat cells-derived exosomes (DFATs-Exos) loaded in GelMA accelerated diabetic wound healing through Wnt/β-catenin pathway.
Dong M, Ma X, Li F
Stem cell research & therapy 2025 Feb 28;16(1):103
Stem cell research & therapy 2025 Feb 28;16(1):103
Danggui niantong decoction attenuates synovial fibrosis through regulating PI3k/AKT signaling pathway.
Liao Q, Wu S, Li X, Yuan LX
Journal of ethnopharmacology 2025 Feb 27;342:119381
Journal of ethnopharmacology 2025 Feb 27;342:119381
MTHFD2 stabilizes LOX expression through RNA methylation modification to promote sepsis-induced acute kidney injury progression.
Sun S, Han B, Ren G, Fan L, Sun J, Li H, Huang J
Human cell 2025 Feb 26;38(2):62
Human cell 2025 Feb 26;38(2):62
Visualizing spatiotemporal pattern of vascularization by SWIR fluorescence imaging in a mouse model of perforator flap transplantation.
Feng S, Chen M, Li H, Zhang X, Du X, Fang L, Xu K, Li S, Chen F, Li Y, Xiong F, Hu D, Mi J, Qin X, Chen J
Journal of nanobiotechnology 2025 Feb 26;23(1):145
Journal of nanobiotechnology 2025 Feb 26;23(1):145
Nucleolin in the cell membrane promotes Ang II-mediated VSMC phenotypic switching by regulating the AT1R internalization function : Nucleolin promotes Ang II-mediated VSMC phenotypic switching.
Fang L, Shen Z, Zhang Y, Mao Z, Huang D, Lou C
Biology direct 2025 Feb 26;20(1):24
Biology direct 2025 Feb 26;20(1):24
Ether bond-modified lipid nanoparticles for enhancing the treatment effect of hepatic fibrosis.
Chu R, Kong J, Gao Q, Yang Y, Pan T, Lu X, Wang Z, Wang Y, He J
International journal of pharmaceutics 2025 Feb 25;671:125192
International journal of pharmaceutics 2025 Feb 25;671:125192
ITIH5-mediated fibroblast/macrophage crosstalk exacerbates cardiac remodelling after myocardial infarction.
Wu Y, Meng L, Zhan S, Li M, Huang J, Chen X, Chen L, Gao X, Chen H, Chen H, Zhong Y, Xu L, Xu Y
Journal of translational medicine 2025 Feb 24;23(1):224
Journal of translational medicine 2025 Feb 24;23(1):224
Drop-shaped microgrooves guide unidirectional cell migration for enhanced endothelialization.
Wang XW, Ye CQ, Tang Q, Yu HM, Wang J, Fu GS, Ren KF, Yu L, Ji J
Nature communications 2025 Feb 24;16(1):1928
Nature communications 2025 Feb 24;16(1):1928
The natural product-derived JM-9 alleviates high-fat diet-induced fatty liver in mice by targeting MD2.
Jin L, Cui Y, Zhang Q, Xiong Y, Zheng X, Ye J, Zhang A, Xiao Z, Zhuang Z, Liang G, Hu X, Luo W, Zhu W
International immunopharmacology 2025 Feb 20;148:114053
International immunopharmacology 2025 Feb 20;148:114053
Interferon regulatory factor 5 attenuates kidney fibrosis through transcriptional suppression of Tgfbr1.
Xu X, Miao M, Zhu W, Zhang L, Jin Q, Li Y, Xu M, Jia Z, Zhang A, Wu M
International immunopharmacology 2025 Feb 20;148:114031
International immunopharmacology 2025 Feb 20;148:114031
The loss of Spinster homolog 2 drives endothelial mesenchymal transition via SMS2-mediated disruption of sphingomyelin metabolism.
Qin JF, Li Y, Wang XD, Tu S, Zhu X, Yin K
Cellular and molecular biology (Noisy-le-Grand, France) 2025 Feb 2;71(1):135-141
Cellular and molecular biology (Noisy-le-Grand, France) 2025 Feb 2;71(1):135-141
Growth Differentiation Factor 15 Inhibits Cardiac Fibrosis, Oxidative Stress, Inflammation, and Apoptosis in a Rat Model of Heart Failure with Preserved Ejection Fraction.
Meng X, Li Y, Meng L, Yang C, Xia C, Wang X, Wang F
Frontiers in bioscience (Landmark edition) 2025 Feb 18;30(2):26857
Frontiers in bioscience (Landmark edition) 2025 Feb 18;30(2):26857
IFN-γ-mediated inhibition of JAK/STAT signaling via nano-scutellarin treatment is an efficient strategy for ameliorating liver fibrosis.
Wang T, Liu B, Huang J, Zhao Q, Shen H, Bi T, Liu Z, Dai Y, Sun Q
Journal of translational medicine 2025 Feb 17;23(1):195
Journal of translational medicine 2025 Feb 17;23(1):195
miR-629-3p inhibits fine particulate matter exposure-induced lung function decline: Results from the two-stage population study and in vitro study.
Zhou M, You X, Zhang J, Ye Z, Song J, Chen B, Fan L, Ma J, Yang S, Cheng M, Chen W
Environmental pollution (Barking, Essex : 1987) 2025 Feb 15;367:125535
Environmental pollution (Barking, Essex : 1987) 2025 Feb 15;367:125535
Modulation of almonertinib resistance in non-small cell lung cancer by cancer-associated fibroblasts through HK2-mediated glycolysis and SKP2 signaling.
Wei G, Fan L, Song X, Zhou W, Sun M, Sun Y, Yao Y, Zhao H, Chen F, Zhu C
Discover oncology 2025 Feb 15;16(1):187
Discover oncology 2025 Feb 15;16(1):187
SCGB1D4 downregulation links to fibrosis in intrauterine adhesion patients and rat models†.
Zhao J, Wang Y, Ma C, Feng Y, Wang Y, Sun S
Biology of reproduction 2025 Feb 14;112(2):273-285
Biology of reproduction 2025 Feb 14;112(2):273-285
Aqueous extract of Cornus officinalis alleviate NAFLD via protecting hepatocytes proliferation through regulation of the tricarboxylic acid cycle.
Liu B, Shao T, Xiao D, Yang S, Lin W, Sun L, Zhang W, Luo M, Zhao J, Yang L, Bai S, Deng D, Wang C, Wang S, Zhang R, Liu Z, An L
Journal of ethnopharmacology 2025 Feb 11;341:119330
Journal of ethnopharmacology 2025 Feb 11;341:119330
Intelligent sequential degradation hydrogels by releasing bimetal-phenolic for enhanced diabetic wound healing.
Zhang Y, Tang Z, Chen L, Yang M, Zeng Y, Bai X, Zhang B, Zhou J, Zhang W, Tang S
Journal of controlled release : official journal of the Controlled Release Society 2025 Feb 10;378:961-981
Journal of controlled release : official journal of the Controlled Release Society 2025 Feb 10;378:961-981
Runx2-NLRP3 axis orchestrates matrix stiffness-evoked vascular smooth muscle cell inflammation.
Li Z, Wu H, Yao F, Li Y, Li Y, Xie SA, Yu F, Fu Y, Wang L, Zhou J, Kong W
American journal of physiology. Cell physiology 2025 Feb 1;328(2):C467-C482
American journal of physiology. Cell physiology 2025 Feb 1;328(2):C467-C482
Plasma-activated solutions prevent peritoneal adhesion formation by regulating eNOS expression in mesothelial cells.
Ma Y, Sun T, Ren K, Ma R, Min T, Wang X, Yuan Y, Xie X, Zhang B, Deng X, Peng Y, Liu Y, Nan Y, Wang W, Zhou Z, Xu G, Li K, Zhu K, Hao N, Dang C, Zhang G, Zhang H
Journal of advanced research 2025 Dec;78:555-571
Journal of advanced research 2025 Dec;78:555-571
SPP1-mediated crosstalk between macrophage and fibroblasts promotes benign airway stenosis.
Niu F, Sun B, Yu Y, Xu X, Li H, Huang L, Wang Y, Cai Z
Archives of biochemistry and biophysics 2025 Dec;774:110627
Archives of biochemistry and biophysics 2025 Dec;774:110627
Uncovering the mechanistic basis of Rheum palmatum L. (rhubarb) in the treatment of chronic kidney disease: an integrative approach using network pharmacology, molecular docking, and experimental validation.
He W, Wei Z, Li S, Han S, Ma J, Wu L, Lu D, Ta G
Pharmaceutical biology 2025 Dec;63(1):582-606
Pharmaceutical biology 2025 Dec;63(1):582-606
Cancer-associated fibroblast-derived extracellular vesicles regulate lipophagy through PLIN2 to modulate dormancy in salivary gland adenoid cystic carcinoma cells.
Dou Z, Zhang X, Meng K, Li M, Pang X, Wang W, Shi R, Liang X, Tang Y
Experimental & molecular medicine 2025 Dec;57(12):2852-2868
Experimental & molecular medicine 2025 Dec;57(12):2852-2868
Qing-Re-Xiao-Zheng-yi-qi formula protects renal function by stabilizing lysosomal membranes and inhibiting NLRP3-inflammasome-mediated pyroptosis in diabetic kidney disease.
Tian L, Wang L, Wang Y, Liu W, Zhao W, Wang Y
Annals of medicine 2025 Dec;57(1):2581157
Annals of medicine 2025 Dec;57(1):2581157
PAI-1 deficiency inhibits endometrial fibrosis via modulation of the FAK/Src/ERK and AKT signalling pathways.
Zhao H, Wang X, Liu J, Yu M, Bao H
Reproductive biomedicine online 2025 Dec;51(6):105120
Reproductive biomedicine online 2025 Dec;51(6):105120
Concentrated Micronized Fat Ameliorates Skin Fibrosis in Bleomycin-Induced Murine Model and Enhances Fat Graft Survival.
Ma X, Dong M, Yin N, Li F
Aesthetic plastic surgery 2025 Dec;49(24):6942-6953
Aesthetic plastic surgery 2025 Dec;49(24):6942-6953
LARS1 Promotes Tubular Epithelial Cells Epithelial Mesenchymal Transition in Chronic Kidney Disease by Inhibiting Lipophagy.
Guo R, Chen MN, Lin QH, Qi HM, Wang XQ, Li BY, Wang S, Xu SJ, Zhang Y, Liu W
Inflammation 2025 Dec;48(6):4094-4109
Inflammation 2025 Dec;48(6):4094-4109
Irisin targets the HK1-glycolysis-NLRP3 pyroptosis axis to prevent chronic kidney disease-associated vascular calcification.
Xu W, Wang P, Zhu X, Zhang Z, Dong X, An R, Pang Q, Zhang A
Renal failure 2025 Dec;47(1):2610545
Renal failure 2025 Dec;47(1):2610545
Aucubin ameliorates diabetic kidney disease by restoring hGENCs autophagy through promoting phosphorylation of ATG4B protein.
Wang H, Yang L, Ao D, Yang K, Zou S, Lin Z, Liu Q, Wen K
Renal failure 2025 Dec;47(1):2605756
Renal failure 2025 Dec;47(1):2605756
Gut microbiota-derived butyrate prevents aortic dissection via GPR41.
Yang HX, Wang BX, Dong XL, Sun J, Miao ZL, Pan LL
Acta pharmacologica Sinica 2025 Dec;46(12):3230-3243
Acta pharmacologica Sinica 2025 Dec;46(12):3230-3243
Mulberry-derived carbon dots attenuate kidney fibrosis through direct inhibition of PI3K.
Liu T, Wu Y, Wang C, Zhou T, Yang R, Zhang X, Yan W, Fan Q, Lu Z
Materials today. Bio 2025 Dec;35:102626
Materials today. Bio 2025 Dec;35:102626
Deoxycholic Acid and Lipoteichoic Acid cooperatively drive macrophage M2/M1 polarization via TGR5/STAT3 and TLR2/NF-κB to fuel HCC progression in obesity.
Wu J, Zheng W, Ding XZ, Jin QP, Ding MX
Metabolism open 2025 Dec;28:100420
Metabolism open 2025 Dec;28:100420
Hypericin-mediated photodynamic therapy promotes apoptosis and inhibits fibrosis by inducing HMOX1-mediated ferroptosis in hypertrophic scar fibroblasts.
Li X, Chen Z, Liu M, An J, Shang J, Zhu G, Wen H, Guo G
Journal of photochemistry and photobiology. B, Biology 2025 Dec;273:113303
Journal of photochemistry and photobiology. B, Biology 2025 Dec;273:113303
Myofibroblast specific knockdown of NSUN2 suppresses cardiac fibrosis post-myocardial infarction.
Sun Z, Li N, Huang M, Li Y, Wang C, Qu Z, Yu S, Mei Z, Wu B, Dou S, Jiang J, Zhang Y, Huang C, Han J, Yue Y, Li X, Dong Y, Du W
Journal of molecular and cellular cardiology 2025 Dec;209:27-36
Journal of molecular and cellular cardiology 2025 Dec;209:27-36
Injectable, antifouling granular zwitterionic hydrogels for preventing postoperative intrauterine adhesion and restoring fertility.
Shi M, Lin J, Wang Q, Yu H, You M, Chen Q, Lin F, Zhang S
Acta biomaterialia 2025 Dec;208:210-225
Acta biomaterialia 2025 Dec;208:210-225
Unveiling the role of Jagged2 in hypoxic pulmonary arterial hypertension: A NOX2-mediated pathway.
Yuan J, Chen Y, Wu S, Shi H, Dong Y, Han Y, Cui W
Journal of cell communication and signaling 2025 Dec;19(4):e70032
Journal of cell communication and signaling 2025 Dec;19(4):e70032
Targeting the ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3Gal1) as a potential therapeutic strategy to overcome anti-VEGF resistance in endometrial cancer.
Liu CH, Yang ST, Chao WT, Lin CH, Lee YC, Lai CR, Hsieh SL, Wang LW, Wang PH
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2025 Dec;171(3):1343-1354
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2025 Dec;171(3):1343-1354
Viscoelastic Hydrogel with Mechanomodulatory Tension Shielding and Time-Dependent Immunomodulatory Effects for Scarless Healing.
Kuan CH, Wang YN, Liao EF, Wang WH, Kung PJ, Huang WY, Chen SH, Chen SH, Hu JJ, Lin SJ, Wang TW
Advanced healthcare materials 2025 Dec;14(32):e01954
Advanced healthcare materials 2025 Dec;14(32):e01954
Hispolon reduces mitochondrial dysfunction and improves fibrosis of diabetes nephropathy by activating AMPK signal and inhibiting mPTP opening.
Wang Y, Danis A, Wang X, Ren J, Ma T, Wang R
Cellular signalling 2025 Dec;136:112130
Cellular signalling 2025 Dec;136:112130
Formononetin, a Key Component of Danggui Buxue Decoction, Inhibits Metastasis of Triple-Negative Breast Cancer by Modulating SNAI2-Driven EMT.
Li K, Zhou T, Wu R, Xiong J
Food science & nutrition 2025 Dec;13(12):e71286
Food science & nutrition 2025 Dec;13(12):e71286
Defective vascular smooth muscle cell tafazzin impairs mitochondrial function and promotes atherosclerosis in preclinical models.
Dong C, Finigan A, Figg N, Jenkins B, Koulman A, Chowdhury SR, Tricolici AM, Lambert J, Oc S, Jørgensen HF, Prudent J, Murphy MP, Bennett M, Yu E
Nature communications 2025 Dec 4;16(1):10909
Nature communications 2025 Dec 4;16(1):10909
Lathyrol Exerts Anti-Pulmonary Fibrosis Effects by Activating PPARγ to Inhibit the TGF-β/Smad Pathway.
Zeng Q, Liao ML, Luo YY, Li S, You G, Huang CM, Liu MH, Liu W, Tang SY
International journal of molecular sciences 2025 Dec 30;27(1)
International journal of molecular sciences 2025 Dec 30;27(1)
HMGB1-enhanced autophagic degradation of E-cadherin facilitates mesothelial trans-differentiation and postoperative peritoneal adhesion.
Yuan X, Yang S, Qu C, Zhang R, Ren Y, Sun Y, Li E, Li G, Zhang J, Du J, Shen T, Jiang Z, Li X
BMC gastroenterology 2025 Dec 30;26(1):83
BMC gastroenterology 2025 Dec 30;26(1):83
He-He-Shu-Yang formula alleviates liver fibrosis by inhibiting hepatic stellate cell activation in vivo and in vitro.
Zeng FL, Shi MJ, Mo YS, Xiao HM, Xie YB, Chi XL
World journal of hepatology 2025 Dec 27;17(12):112835
World journal of hepatology 2025 Dec 27;17(12):112835
SREBP1-mediated lipogenesis promotes dedifferentiation and senescence of vascular smooth muscle cells through epigenetic remodeling.
Li B, Zhou K, Yin A, Liu Y, Wang X, Cui Y, Liu F, Liu Q, Zheng H, Mu Z, Chen K, Wu Y, Chang Y, Bao J
Nature communications 2025 Dec 26;17(1):835
Nature communications 2025 Dec 26;17(1):835
Single-cell RNA sequencing identifies ZBP1-dependent mechanisms in OSCC progression.
Lin X, Wang C, Li C, Wu J, Zhang P, Zhang C, Chen H, Xu F, Zhang S, Luo C, Tang C
Cell death & disease 2025 Dec 22;16(1):918
Cell death & disease 2025 Dec 22;16(1):918
Saffron and Calculus bovis combination exerts anti-hepatic fibrotic effect in liver fibrosis rats via the mitogen-activated protein kinases pathway.
Sun SN, Wang K, Xu Y, Ye F, Xia WN, Wang ZW, Liu F, He ZX, Chen M, Du QH
World journal of gastroenterology 2025 Dec 21;31(47):113496
World journal of gastroenterology 2025 Dec 21;31(47):113496
CD146(+) CAFs mediate immunosuppression in gastric cancer via COL4A1: potential therapeutic targets.
Chen J, Xu P, Wang Q, Dai J, Liang S, Yang S, Xie G, Li X, Wang Y, Hua H, Ping X, Shen J, Shen L
Journal for immunotherapy of cancer 2025 Dec 21;13(12)
Journal for immunotherapy of cancer 2025 Dec 21;13(12)
Vitisin A inhibits liver fibrosis by promoting Nrf2/HO-1 pathway and inhibiting Cuproptosis.
Ding S, Hu D, Pan Y, Wang J, Wang L
Scientific reports 2025 Dec 19;15(1):44186
Scientific reports 2025 Dec 19;15(1):44186
Lupiwighteone Ameliorates Diabetic Nephropathy-Induced Renal Fibrosis via SIRT1/NF-κB Signaling Pathway-Mediated Inflammatory Response.
Yang H, Pan H, Chen Z, Wang Y, Jiang W, Fang H, Yan K, Ren J, Tang L, Xu S
Journal of agricultural and food chemistry 2025 Dec 17;73(50):31942-31956
Journal of agricultural and food chemistry 2025 Dec 17;73(50):31942-31956
Multi-omics factor analysis identifies the Tensin 1-Fermitin family homologue 2-Fibronectin 1-Integrin signaling axis as a prognostic determinant in colorectal cancer.
Chen T, Yang Y, Shi J, Dong F, Xie L, Shan Y, Wang X
Molecular biomedicine 2025 Dec 17;6(1):141
Molecular biomedicine 2025 Dec 17;6(1):141
In vitro and in vivo hemocompatibility study of fish swim bladder-derived biomaterials for the application of chronic venous disease.
Zong Q, Chen Y, Kong Y, Wang Z, Dang Y, Liu J
Journal of materials science. Materials in medicine 2025 Dec 17;37(1):1
Journal of materials science. Materials in medicine 2025 Dec 17;37(1):1
Alkaline Phosphatase-Triggered Spatiotemporal Repair of Corneal Injury with TB500 Peptide Hydrogel.
Lu P, Shan M, Peng C, Ji W, Yang T, Yang Z, Zhang Z, Wang Y
ACS applied materials & interfaces 2025 Dec 17;17(50):67503-67518
ACS applied materials & interfaces 2025 Dec 17;17(50):67503-67518
HPDA-based tubule-targeting nanoplatform alleviates oxidative stress and ferroptosis for the reversal of renal interstitial fibrosis.
Xiao Z, Luo P, Li G, Tan H, Zhou C, Zeng D, Chen Y, Li Y
Journal of nanobiotechnology 2025 Dec 13;24(1):57
Journal of nanobiotechnology 2025 Dec 13;24(1):57
Human umbilical cord-derived mesenchymal stem cells ameliorate non-alcoholic fatty liver disease via activating TFEB-mediated autophagy in male mice.
Zhang H, Liu P, Deng Y, Wu L, Fan O, Cui Y, Zhang C, Zhu W, Sun YE, Lin C, Wang C
Stem cell research & therapy 2025 Dec 13;17(1):34
Stem cell research & therapy 2025 Dec 13;17(1):34
Heterogeneity of common carotid artery and abdominal aorta: an angle of sphingolipid metabolism in vascular smooth muscle cells.
Li B, Zhou K, Chen K, Jiang S, Wang X, Gu Z, Gu C, Han Y, Liu Y, Chang Y, Bao J
Biomedical engineering online 2025 Dec 10;25(1):7
Biomedical engineering online 2025 Dec 10;25(1):7
Renal insulin-like growth factor binding-protein 7 is a critical promoter of progressive diabetic kidney disease.
Yu JT, Hu XW, Wang JN, Yang Q, Li XY, Shan RR, Pu T, Hou R, Shen XY, Wang YQ, Zhang F, Yu XW, Wang J, Li FH, Wen JG, Fan Y, Jin J, Jiang YY, Meng XM
Nature communications 2025 Dec 1;17(1):30
Nature communications 2025 Dec 1;17(1):30
Activation/inactivation of Tregs mediated by Kv1.3 potassium channels synergistically with exosome secretion to regulate myocardial fibrosis.
Li M, Wu Y, Zhang Y, Wang Z, Cheng L, Xie X
Scientific reports 2025 Dec 1;15(1):45756
Scientific reports 2025 Dec 1;15(1):45756
Comparative study of bladder augmentation using different biomimetic scaffolds: electrospun nanofiber vs. extracellular matrix scaffold with adipose-derived stem cells.
Wang X, Zhang F, Zhou Z, Fu Q, Liao L
International journal of surgery (London, England) 2025 Dec 1;111(12):9089-9101
International journal of surgery (London, England) 2025 Dec 1;111(12):9089-9101
RalGAP complexes control secretion and primary cilia in pancreatic disease.
Apken LH, Barz H, Beel S, Michalke E, Rasche R, Verma A, Ricker A, Nüsse H, Klingauf J, Kerl K, Wardelmann E, Kümmel D, Steinestel K, Pethő Z, Meisterernst M, Oeckinghaus A
Life science alliance 2025 Aug;8(8)
Life science alliance 2025 Aug;8(8)
Pathology-inspired collagen-binding thermosensitive micelle drops enable prolonged and efficient treatment of fungal keratitis.
Cai M, Zhong H, Wang X, Li L, Zhou X, Wang Y, Hua X, Guo S, Yuan X
Bioactive materials 2025 Aug;50:396-413
Bioactive materials 2025 Aug;50:396-413
Aerobic exercise activates let-7e-5p through TP73-AS1 to inhibit the HMGB1/RAGE axis and alleviate asthma airway inflammation and remodeling.
Wang D, Zhao J, Yang C, Qin D, Zhu D
Cellular immunology 2025 Aug;414:104990
Cellular immunology 2025 Aug;414:104990
Adhesive hydrogel based on Konjac Glucomannan (KGM) loaded with siACTC1-exosomes for enhanced post-surgical keloid treatment.
Zhong Y, Zhang Y, Liu Y, Zeng K, Fan L, Wang Q, Zhang J
International journal of biological macromolecules 2025 Aug;319(Pt 3):145360
International journal of biological macromolecules 2025 Aug;319(Pt 3):145360
Influence of Huaiqihuang granule on peritoneal fibrosis induced by peritoneal dialysis: A study based on rat model.
Jia L, Liu H, Li Y, Huang Y
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 2025 Aug;29(4):653-661
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 2025 Aug;29(4):653-661
The role of FAK in renal collecting duct in the progression from acute kidney injury to chronic kidney disease.
Gao C, He J, Wang Y, Shao G, Lin S, Liu J, Ren C, Quan Y, Ying Y, Li M, Yang B, Zhou H
Translational research : the journal of laboratory and clinical medicine 2025 Aug;282:41-55
Translational research : the journal of laboratory and clinical medicine 2025 Aug;282:41-55
p66shc exacerbates the progression of obstructive nephropathy through apoptosis, mitochondrial damage, and EMT.
Gao X, Fan X, Yu X, Wang R, Zhang B, Li Y, Liu X, Yang Y
Journal of pediatric urology 2025 Aug;21(4):834-843
Journal of pediatric urology 2025 Aug;21(4):834-843
m6A-mediated regulation of ECA39 promotes renal fibrosis in chronic kidney disease by enhancing glycolysis and epithelial-mesenchymal transition.
Tong Z, Zhao H, Cui C, Hong M, Ma Y, Sui L, Wang J, Yuan Q, Sun L
Biochimica et biophysica acta. Molecular cell research 2025 Aug;1872(6):119981
Biochimica et biophysica acta. Molecular cell research 2025 Aug;1872(6):119981
Inhibition of VSMC Ferroptosis Mitigates Pathological Vascular Remodeling: A Novel Therapeutic Strategy for Abdominal Aortic Aneurysm.
Zhou Y, Chen Y, Cui Y, Gan N, Xiang Q, Li M, Zeng W, Zheng XL, Dai X, Peng J, Tang Z
Journal of cardiovascular translational research 2025 Aug;18(4):785-799
Journal of cardiovascular translational research 2025 Aug;18(4):785-799
Revealing a new target: Celastrol alleviates pulmonary fibrosis by inhibiting PCAF.
Wang L, Lin F, Liu J, Jia Z, Zhu M, Liu Y, Li Y, Yang L
Bioorganic chemistry 2025 Aug;163:108722
Bioorganic chemistry 2025 Aug;163:108722
Engineered MSC Aggregates with E/N-Cadherin and IL-6 Preconditioning for the Treatment of Systemic Sclerosis.
Zhang Y, Qian M, Shi Y, Cao J, Xu M, Wen X, Yan Y, Liu S, Chen H, Liu S, Yang J, Sun L
Advanced healthcare materials 2025 Aug;14(20):e2500663
Advanced healthcare materials 2025 Aug;14(20):e2500663
Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Combined with PEG Hydrogel Alleviate Maternal Simulated Birth Injury in a Rat Model.
Wang Q, Li Y, Zhang Y, Wu X, Wang S, Sun X, Wang J
Advanced healthcare materials 2025 Aug;14(20):e2405259
Advanced healthcare materials 2025 Aug;14(20):e2405259
F-box only protein 10 protects against kidney tubulointerstitial fibrosis by inhibiting ACSL4-mediated lipid peroxidation and ferroptosis.
Hu J, Ma F, Chen X, Lu X, Lu Y, Jiang Y
Cellular signalling 2025 Aug;132:111841
Cellular signalling 2025 Aug;132:111841
Oxidized-LDL aggravates renal injury via tubular cuproptosis.
Sun DQ, Zhong MY, Zhang JH, Tang H, Hu B, Shen JQ, Yan F, Xu XY, Chen K, Targher G, Byrne CD, Zheng MH, Zhao J, Wang RF
Cellular signalling 2025 Aug;132:111839
Cellular signalling 2025 Aug;132:111839
Vascular Smooth Muscle-Secreted Exosomal X26nt Impedes Atherosclerosis Progression via the c-FOS/XBP1/SOD1 Axis.
Zhang Z, Liu D, Zheng Y, Liu Y, Cheng X, Chang Y, Liang X, Hu X, Gao W
Immunity, inflammation and disease 2025 Aug;13(8):e70251
Immunity, inflammation and disease 2025 Aug;13(8):e70251
Paracrine Orchestration of Tumor Microenvironment Remodeling Induced by GLO1 Potentiates Lymph Node Metastasis in Breast Cancer.
Xie J, Liu W, Deng X, Wang H, Ou X, An X, Situ MY, Yang A, Peng C, He R, Xie Y, Tang H, Chen Y, Liang JY, Shao R, Xiao W, Zheng S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(32):e00722
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(32):e00722
PGC1α regulates the mitochondrial metabolism response to cyclic stretch, which inhibits neointimal hyperplasia.
Zou M, Ye K, Yan J, Zhang S, Bao H, Li Z, Tao Y, Zhang X, Tian W, Qi Y, Huo Y, Han Y
Cellular and molecular life sciences : CMLS 2025 Aug 8;82(1):303
Cellular and molecular life sciences : CMLS 2025 Aug 8;82(1):303
SETD2 drives METTL14-mediated m(6)A to suppress Piezo1 Attenuation and activate TGM2 to promote pulmonary hypertension.
Zhao SS, Yuan C, Liu JL, Wu QC, Zhou XL
Cellular and molecular life sciences : CMLS 2025 Aug 8;82(1):302
Cellular and molecular life sciences : CMLS 2025 Aug 8;82(1):302
Neurotensin receptor1 signaling promotes progression of epithelial-mesenchymal transition in mice with chronic rhinosinusitis through Wnt3a/β-catenin pathway.
Wu Y, Zhu X, Gu H, Fu F, Guo Q, Liu K, Yang M, Zhang T, Wang X
Journal of molecular histology 2025 Aug 6;56(4):253
Journal of molecular histology 2025 Aug 6;56(4):253
Renal tubular epithelial IGFBP7 interacts with PKM2 to drive renal lipid accumulation and fibrosis.
Yu JT, Xie SS, Shen XY, Li Z, Hu XW, Zhang Y, Dong ZH, Wang JN, Li XY, Dong YH, Li C, Ji ML, Suo XG, Yang C, Jin J, Wang W, Wen JG, Liu MM, Li L, Yang Q, Meng XM
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Aug 6;33(8):3757-3777
Molecular therapy : the journal of the American Society of Gene Therapy 2025 Aug 6;33(8):3757-3777
SRPK1 is a significant factor in driving the progression of diabetic kidney fibrosis.
Han S, Ma S, Liu K, Qi R, Wang G, Qin W, Zhang X
Diabetology & metabolic syndrome 2025 Aug 6;17(1):316
Diabetology & metabolic syndrome 2025 Aug 6;17(1):316
Arachidonic acid triggers spermidine synthase secretion from primary tumor to induce skeletal muscle weakness upon irradiation.
Zhang X, Nie Z, Wang S, Ma Y, Han D, Hu T, Liu L, Men L, Zhang T, Wu X, Li X, Hu S, Yuan M, Liu L, Wang C, Xu P, Xiang L, Liu J, Zhang Y, Zhu D, Lei H, Zhang L, Li X, Zhao Y, Yan W
Cell metabolism 2025 Aug 5;37(8):1766-1782.e12
Cell metabolism 2025 Aug 5;37(8):1766-1782.e12
A Bifunctional Anti-PD-1/TGF-β Fusion Antibody Restores Antitumour Immunity and Remodels the Tumour Microenvironment.
Nan L, Qin Y, Huang X, Pan M, Wang X, Lv Y, Sorensen A, Kang X, Ling H, Zhang J
International journal of molecular sciences 2025 Aug 5;26(15)
International journal of molecular sciences 2025 Aug 5;26(15)
Therapeutic and prophylactic effects of Qipian on COPD in mice: the role of lung and gut microbiota.
Sun G, Hao W, Li Q, Ma Y, Sun F, Su Y, Yu X, Han W
Microbiology spectrum 2025 Aug 5;13(8):e0196924
Microbiology spectrum 2025 Aug 5;13(8):e0196924
Kurarinone protects against renal injury and fibrosis after unilateral ureteral obstruction through enhancement of the Nrf-2 signaling pathway.
Dong T, Zhao D, Jiang S, Gu Y, Wang C, Yang Q, Liu T, Liu X
Journal of molecular histology 2025 Aug 29;56(5):286
Journal of molecular histology 2025 Aug 29;56(5):286
Activated Schwann cells promote tumor growth in colon cancer.
He K, Wang H, Wu H, Li W, Huo R, Jiang L, Yu M, Xue J
Cancer letters 2025 Aug 28;626:217791
Cancer letters 2025 Aug 28;626:217791
Silybin Mitigates Post-Myocardial Infarction Heart Failure in Mice via Modulation of HIF-1α-Driven Glycolysis and Energy Metabolism.
Wang M, Chen J, Zhang Z, Wang T, Zhao J, Wang X, Wang J, Zhuang H
Nutrients 2025 Aug 28;17(17)
Nutrients 2025 Aug 28;17(17)
S100a8 inhibitor Paquinimod attenuates coal dust-induced pulmonary fibrosis via blocking neutrophils-S100a8-Tlr4-macrophages signaling axis.
Du M, Hu S, Cao W, Li B, Jin H, Wang F, Yan R, Li X, Xie Z, Zou Y, Tao X, Wang W, Li Y, Mu M
International immunopharmacology 2025 Aug 28;161:115020
International immunopharmacology 2025 Aug 28;161:115020
Induction and characterization of oral submucous fibrosis model with different pathological stages in rats and mice.
Tang J, Zhou Z, Wang G, Tu H, Cui X, Jia J, Dai X, Liu O
Scientific reports 2025 Aug 24;15(1):31128
Scientific reports 2025 Aug 24;15(1):31128
Ultrasound-triggered targeted delivery of engineered ADSCs-derived exosomes with high SDF-1α levels to promote cardiac repair following myocardial infarction.
Wang H, Jiang R, Zhong F, Hu Y, Liu J, Chen Y, Su W, Cao S, Zhou Q, Deng Q
International journal of pharmaceutics 2025 Aug 20;681:125786
International journal of pharmaceutics 2025 Aug 20;681:125786
Hypoxia-induced exosomal circNRIP1 activates cancer-associated fibroblasts to promote esophageal squamous cell carcinoma migration and invasion.
Qiao G, Li C, Wang M, Zhang W, Shi J, Meng B, Zhang L, Zhang R, Qi H, Xin S
BMC gastroenterology 2025 Aug 20;25(1):605
BMC gastroenterology 2025 Aug 20;25(1):605
Eupatorium lindleyanum DC Ameliorates Carbon Tetrachloride-Induced Hepatic Inflammation and Fibrotic Response in Mice.
Yang J, Wang Y, Zhuo L, Lu G, Zhang M, Huang J, Li Y, Liu W, Qi J, Zhu A, Zhou Z
Pharmaceuticals (Basel, Switzerland) 2025 Aug 20;18(8)
Pharmaceuticals (Basel, Switzerland) 2025 Aug 20;18(8)
Phosphoglycerate kinase 1 contributes to diabetic kidney disease through enzyme-dependent and independent manners.
Sun HJ, Lu QB, Liu SJ, Fu X, Yu CL, Su JB, Meng XY, Guo X, Shao X, Li JH, Sun QY, Zhu XX, Shan JJ, Zhou W
Cell reports. Medicine 2025 Aug 19;6(8):102241
Cell reports. Medicine 2025 Aug 19;6(8):102241
The protective role of ureteral stents in reducing fibrosis and preventing stricture in ureteral injuries of different severities.
Gu H, Yang T, Qin Z, Zhang S, Wang L, Zhao Z
BMC urology 2025 Aug 19;25(1):204
BMC urology 2025 Aug 19;25(1):204
Noncanonical function of Pannexin1 promotes cellular senescence and renal fibrosis post-acute kidney injury.
Huang L, Shen Y, Pan X, Li J, Li C, Ruan L, He S, Huang L, Liu K, Zhao X, Geng J, Guo J, Hou FF, Wang J
Nature communications 2025 Aug 19;16(1):7699
Nature communications 2025 Aug 19;16(1):7699
Cancer cell SPOCD1 promotes colorectal cancer liver metastasis by activating the CXCL12/CXCR4 signaling pathway in cancer-associated fibroblasts.
Peng G, Zhong L, Luo L, Ju Y, Lu Y, Ng L, Foo DC, Cheng F, Huang L, Ouyang M
Journal of translational medicine 2025 Aug 13;23(1):902
Journal of translational medicine 2025 Aug 13;23(1):902
Sorafenib inhibits ovarian inflammation and fibrosis in polycystic ovary syndrome by targeting the PDGFA/PDGFRα/NF-κB pathway in granulosa cells†.
Liu X, Wang Y, Wang Y, Bai Y, Kang A, Cai Q, Liu H, Zhang M, Xu C, Zhang F
Biology of reproduction 2025 Aug 13;113(2):423-435
Biology of reproduction 2025 Aug 13;113(2):423-435
NAT10 Mediates Cardiac Fibrosis Induced by Myocardial Infarction Through ac4C Modification of TGFBR1 mRNA.
Zhou J, Chen Y, Chen J, Xia G, Zeng J, Wang L
Cell biology and toxicology 2025 Aug 12;41(1):125
Cell biology and toxicology 2025 Aug 12;41(1):125
Targeted Delivery of CD34 Aptamer-Coupled Tocilizumab Microspheres for Effective Treatment of Thyroid-Associated Ophthalmopathy.
Luo Y, Yin J, Cao J, Xie B, Zhang F, Ouyang S, Zhou J, Tan Y, Xiong W
Investigative ophthalmology & visual science 2025 Aug 1;66(11):57
Investigative ophthalmology & visual science 2025 Aug 1;66(11):57
Integrated Proteomics Reveals Spliceosome Dysregulation and Highlights DHX9 as a TGF-β Signaling-Driven Fibrosis Hub in Endometriosis.
Yang M, Zhang L, Ding X, Wei P, Zhang H, Chen J, Zhang Y, Li D, Chen Z, Lin D, Huang Z, Chen Q
Journal of proteome research 2025 Aug 1;24(8):4044-4059
Journal of proteome research 2025 Aug 1;24(8):4044-4059
Anti-Radiofibrosis Effect of Dicliptera chinensis Polysaccharide on Rat Dermal Fibroblasts Via The TGF-β1/Smads/CTGF Signaling Pathway.
Huang Y, Zhao L, Zhao Y, Fan Y, Gao L, Lu H, Wang X, Mo D, Wang D
International dental journal 2025 Apr;75(2):1338-1347
International dental journal 2025 Apr;75(2):1338-1347
Spatially resolved transcriptomic analysis of the adult human prostate.
Hu J, Liu F, Zhang J, Yin L, Cao W, Xu W, Chang Y, Wang Y, Wang J, Hou Y, Liu L, Chen S, Zhu G, Jiang J, Wang Z, Wei GH, He HH, Gu D, Chen K, Ren S
Nature genetics 2025 Apr;57(4):922-933
Nature genetics 2025 Apr;57(4):922-933
Agathis dammara Extract and its Monomer Araucarone Attenuate Abdominal Aortic Aneurysm in Mice.
Zhang Q, Cai Z, Yu Z, Di C, Qiu Y, Qi R
Cardiovascular drugs and therapy 2025 Apr;39(2):239-257
Cardiovascular drugs and therapy 2025 Apr;39(2):239-257
Engineered MSCs Break Endothelial-Myofibroblast Crosstalk in Pulmonary Fibrosis: Reconstructing the Vascular Niche.
Fang YF, Zhang C, Han MM, Wang Y, Zhou TJ, Xing L, Wei N, Wang J, Jeong JH, Zhou F, Wang GJ, Jiang HL
Advanced materials (Deerfield Beach, Fla.) 2025 Apr;37(13):e2414601
Advanced materials (Deerfield Beach, Fla.) 2025 Apr;37(13):e2414601
CIP2A promotes bronchiolitis obliterans by activating the NF‑κB pathway.
Zhou X, Zhao X, Li Y, Zhang B
Molecular medicine reports 2025 Apr;31(4)
Molecular medicine reports 2025 Apr;31(4)
Role of the integrin‑β1/TGF‑β1 signaling pathway in the pathogenesis of pelvic organ prolapse: A study on vaginal wall tissue alterations and molecular dysfunction.
Kong M, Wang Z, Hao Y, Shi Y, Yang X, Djurist NR, Li Y
Molecular medicine reports 2025 Apr;31(4)
Molecular medicine reports 2025 Apr;31(4)
Uniform and controllable surface nano-structure on polyetheretherketone implants can regulate mechanical property to enhance soft tissue integration through Piezo1/TGF-β1 signaling axis.
Liu S, Chen Y, Zhou G, Sun C, Ma M, Huang R, Li X, Liang X, Shi C, Wu W, Yan X, Wang L, Han J
Materials today. Bio 2025 Apr;31:101645
Materials today. Bio 2025 Apr;31:101645
Exosome-loaded tannic acid-thioctic acid hydrogel enhances wound healing in coagulation disorders.
Tu Y, Zheng W, Ding Z, Xiang J, Yang Q, Liu Y, Cao J, Shen Y, Tang Z, Lin S, Fan L, Xu Y, Chen B
Materials today. Bio 2025 Apr;31:101496
Materials today. Bio 2025 Apr;31:101496
circSIRT2/miR-542-3p/VASH1 axis regulates endothelial-to-mesenchymal transition (EndMT) in subretinal fibrosis in age-related macular degeneration models.
Zhang M, Wu J, Wang Y, Wu Y, Wan X, Jiang M, Bo Q, Chen J, Sun X
Aging cell 2025 Apr;24(4):e14443
Aging cell 2025 Apr;24(4):e14443
Targeting PDK1: A novel approach to combat hypoxia-induced epithelial-mesenchymal transition in chronic rhinosinusitis with nasal polyps.
Pan S, Zhuang M, Wang X, Zhang Q, He T, Li Y, Jiao J, Zhang L
Clinical and translational allergy 2025 Apr;15(4):e70048
Clinical and translational allergy 2025 Apr;15(4):e70048
CircHOMER1 promotes silica-induced pulmonary fibrosis by binding to HuR and stabilizing NOX4 mRNA.
Wu Q, Zhang Q, Jin C, Liu X, Yu H
Cellular signalling 2025 Apr;128:111638
Cellular signalling 2025 Apr;128:111638
Deficiency of HSF4 Increases the Secretion of Small Extracellular Vesicles via Upregulation of Chaperone-Mediated Autophagy.
Liu J, Liu X, Xie X, Si W, Zhang Y, Xue M, Peng X, Jiang M, Du S, Shao J, Mao Y, Zhang F, Hu Y
Journal of cellular biochemistry 2025 Apr;126(4):e70031
Journal of cellular biochemistry 2025 Apr;126(4):e70031
Construction of a Biomimetic Tubular Scaffold Inspired by Sea Sponge Structure: Sponge-Like Framework and Cell Guidance.
Meng S, Wu N, Fang J, Yu Y, Tang X, Wang Y, Deng X, Qi C, Kong T, Ding T, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2416627
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2416627
Electret-Inspired Charge-Injected Hydrogel for Scar-Free Healing of Bacterially Infected Burns Through Bioelectrical Stimulation and Immune Modulation.
Liu M, Wang Y, Wang H, Qi L, Shang Y, Song J, Feng X, Chen Y, Memon WA, Shen Y, Wu X, Cao J, Zhao Y, Jiang Z, Liu D, Shafique S, Li S, Lu G, Wei Z, Liu Z, Zhou K, Quan Y, Zhang X, Zou X, Wang X, Liu N, Zhang Y, Hu Y, Han C, Wang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2411889
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2411889
Metformin Alleviates Fibrosis of Trabecular Meshwork Cells Induced by TGFβ2 Through the Activation of Autophagy.
Ren J, Wu P, Liu M, Zhang X, Guo Z, Liu Y, Zhao R, Wang G, Duan S, Li H
Dose-response : a publication of International Hormesis Society 2025 Apr-Jun;23(2):15593258251341598
Dose-response : a publication of International Hormesis Society 2025 Apr-Jun;23(2):15593258251341598
Microenvironment-adaptive nanomedicine MXene promotes flap survival by inhibiting ROS cascade and endothelial pyroptosis.
Yang N, Hua R, Lai Y, Zhu P, Ding J, Ma X, Yu G, Xia Y, Liang C, Gao W, Wang Z, Zhang H, Yang L, Zhou K, Ge L
Journal of nanobiotechnology 2025 Apr 7;23(1):282
Journal of nanobiotechnology 2025 Apr 7;23(1):282
Suppression of Liver Fibrogenesis with Photothermal Sorafenib Nanovesicles via Selectively Inhibiting Glycolysis and Amplification of Active HSCs.
Xiang X, Shao Y, Xiang L, Jiao Q, Zhang W, Qin Y, Chen Y
Molecular pharmaceutics 2025 Apr 7;22(4):1939-1957
Molecular pharmaceutics 2025 Apr 7;22(4):1939-1957
Intranasal delivery of R8-modified circNFXL1 liposomes ameliorates Su5416-induced pulmonary arterial hypertension in C57BL/6 mice.
Li SS, Guo M, Zhao Y, Fan F, Huang S, Yang H, Chen X, Jin X
Respiratory research 2025 Apr 6;26(1):127
Respiratory research 2025 Apr 6;26(1):127
LncRNA-5829: a novel inhibitor of cardiac fibrosis.
Zhang X, Du Y, Xu J, Zhang W, Wen X, Zhou T, Hong H, Cheng R, Zhang R
Cardiovascular diagnosis and therapy 2025 Apr 30;15(2):302-317
Cardiovascular diagnosis and therapy 2025 Apr 30;15(2):302-317
OTUD1 inhibits endometriosis fibrosis by deubiquitinating MADH7.
Chang X, Zhang Y, Deng M, Yang R, Zhang J, Hao M, Miao J
Molecular human reproduction 2025 Apr 3;31(2)
Molecular human reproduction 2025 Apr 3;31(2)
Cathepsin D inhibits AGEs-induced phenotypic transformation in vascular smooth muscle cells.
He X, Tian S, Bu L, Zhao X, Zheng L, Zhang P, Guo R, Ma M
Scientific reports 2025 Apr 3;15(1):11502
Scientific reports 2025 Apr 3;15(1):11502
KIF2C promotes oral squamous cell carcinoma progression via PLK1 upregulation: implications for biomarker development and therapeutic targeting.
Wang C, Su Y, Shi J, Feng G
Journal of molecular histology 2025 Apr 28;56(3):146
Journal of molecular histology 2025 Apr 28;56(3):146
PYK2 promotes cell proliferation and epithelial-mesenchymal transition in endometriosis by phosphorylating Snail1.
Liu L, Liu L, Yue C, Du S, Liu J, Yu Z
Molecular medicine (Cambridge, Mass.) 2025 Apr 27;31(1):155
Molecular medicine (Cambridge, Mass.) 2025 Apr 27;31(1):155
Development of a Long-Acting Interleukin-11 Antagonist for the Treatment of Renal Fibrosis.
Pang N, Zhao N, An C, Li K, Li P, Wang N, Li J, Cheng X, Zheng N, Guo D, Xiong X
Journal of medicinal chemistry 2025 Apr 24;68(8):8429-8438
Journal of medicinal chemistry 2025 Apr 24;68(8):8429-8438
USP22/BRD4 mediated hedgehog pathway activation contributes to airway remodeling in asthma.
Chen H, Liu J, Zhang J, Chen Y, Wang Y, Qiu Y, Hu H, Chai L, Zhang Q, Wang Q, Li M
International immunopharmacology 2025 Apr 24;153:114538
International immunopharmacology 2025 Apr 24;153:114538
Mechanism of Astragalus Polysaccharide in Alleviating Bovine Mammary Fibrosis Through ROS/NLRP3 Inhibition and EMT Regulation.
Zhang J, Liu K, Yang T, Duan H, Xiao L, Zhang Q, Zhang Y, Dong W, Zhao X
Antioxidants (Basel, Switzerland) 2025 Apr 23;14(5)
Antioxidants (Basel, Switzerland) 2025 Apr 23;14(5)
Estrogen Inhibits the Phenotypic Switching of Vascular Smooth Muscle Cells through ER-α/CREB in Aortic Dissection.
Pu Y, Zhou Y, Guo T, Chai X, Yang G
ACS omega 2025 Apr 22;10(15):15256-15271
ACS omega 2025 Apr 22;10(15):15256-15271
Autophagy inhibition enhances antifibrotic potential of placental mesenchymal stem cells of fetal origin via regulating TGF-β1 mediated protein degradation of HGF.
Zhou W, Wang J, Ding L, Cai R, Cheng J, Liang P, Zhu Y, Zhang Z
Scientific reports 2025 Apr 21;15(1):13805
Scientific reports 2025 Apr 21;15(1):13805
Deficiency of IL-7R attenuates abdominal aortic aneurysms in mice by inhibiting macrophage polarization towards M1 phenotype through the NF-κB pathway.
Xu S, Han X, Yu Y, Qu C, Yang B, Shen B, Liu X
Molecular medicine (Cambridge, Mass.) 2025 Apr 16;31(1):138
Molecular medicine (Cambridge, Mass.) 2025 Apr 16;31(1):138
Epithelial FETUB-mediated the inhibition of NEP activity aggravates asthma.
Sun P, Hua Q, Fu H, Yao L, Yuan X, Li Q, Li Y, Jia M, Xia R, Yao X
International immunopharmacology 2025 Apr 16;152:114397
International immunopharmacology 2025 Apr 16;152:114397
miR-29 inhibits endothelial-to-mesenchymal transition in pulmonary hypertension of the newborn by regulating LRP6.
Wang Y, Sun L, Jia X, Yang M, Xu W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 15;39(7):e70502
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 15;39(7):e70502
Galectin-1 regulates scar hyperplasia by modulating NASP variable splicing to generate ROS.
Yu Y, Ma S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 15;39(7):e70478
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 15;39(7):e70478
NLRP3 inflammasome-mediated premature immunosenescence drives diabetic vascular aging dependent on the induction of perivascular adipose tissue dysfunction.
Tai GJ, Ma YJ, Feng JL, Li JP, Qiu S, Yu QQ, Liu RH, Wankumbu SC, Wang X, Li XX, Xu M
Cardiovascular research 2025 Apr 15;121(1):77-96
Cardiovascular research 2025 Apr 15;121(1):77-96
Molecular network strategies combined with MCnebula2 identify potential active compounds from steamed Polygonatum cyrtonema Hua.
Chen S, Wang L, Lyu Q, Shan Q, Han X, Yang Q, Dong Z, Sang X, Yu Q, Lu J, Hao M, Wang K, Cao G
Journal of chromatography. A 2025 Apr 12;1746:465779
Journal of chromatography. A 2025 Apr 12;1746:465779
The sonic hedgehog signaling inhibitor cyclopamine improves pulmonary arterial hypertension via regulating the bone morphogenetic protein receptor 2 pathway.
Jin Y, Mao F, Wang X, Zhang J, Gao Y, Fan Y
Scientific reports 2025 Apr 11;15(1):12512
Scientific reports 2025 Apr 11;15(1):12512
The CD163 + tissue-infiltrating macrophages regulate ferroptosis in thyroid-associated ophthalmopathy orbital fibroblasts via the TGF-β/Smad2/3 signaling pathway.
Li X, Wang S, Cao H, Xu S, Xiong C, Yu J, Chen Y, Ren Z, Li M, Hu Y, Gan P, Xu Q, Wang Y, Liao H
Journal of translational medicine 2025 Apr 10;23(1):423
Journal of translational medicine 2025 Apr 10;23(1):423
Lack of ALCAT1 enhances the protective effects of aerobic exercise on kidney in HFpEF mice.
Zhang L, Feng L, Zhao Y, Geng Y, Liu R, Ma Y, Bo W, Xi Y, Tian Z
Life sciences 2025 Apr 1;366-367:123500
Life sciences 2025 Apr 1;366-367:123500
Triclosan exposure induces liver fibrosis in mice: The heterogeneous nuclear ribonucleoprotein A1/pyruvate kinase M2 axis drives hepatic stellate cell activation.
Ni X, Wei Z, Peng Y, Zheng L, Shang J, Liu F, Li Y, Liu J
Ecotoxicology and environmental safety 2025 Apr 1;294:118113
Ecotoxicology and environmental safety 2025 Apr 1;294:118113
Effect of Engineered Cyanobacterial Capsules on a Neurogenic Bladder after Spinal Cord Injury.
Xiao Y, He Y, Zhong D, Liu B, Tang Z, Lan X, Dong Y, Du H, Liu Y, Luo J
ACS nano 2025 Apr 1;19(12):11841-11860
ACS nano 2025 Apr 1;19(12):11841-11860
Identification and validation of CDC20 and ITCH as ubiquitination related biomarker in idiopathic pulmonary fibrosis.
Sun S, Wang Y, Feng J
Hereditas 2025 Apr 1;162(1):50
Hereditas 2025 Apr 1;162(1):50
An Integrated Dual-Layer Heterogeneous Polycaprolactone Scaffold Promotes Oral Mucosal Wound Healing through Inhibiting Bacterial Adhesion and Mediating HGF-1 Behavior.
Hong G, Hu Z, Zhou Y, Chen M, Wu H, Lu W, Jin W, Yao K, Xie Z, Shi J
Research (Washington, D.C.) 2024;7:0499
Research (Washington, D.C.) 2024;7:0499
Fabrication of 3D Biomimetic Smooth Muscle Using Magnetic Induction and Bioprinting for Tissue Regeneration.
Luo Y, Hu Z, Ni R, Xu R, Zhao J, Feng P, Zhu T, Chen Y, Yao J, Yao Y, Yang L, Zhang H, Zhu Y
Biomaterials research 2024;28:0076
Biomaterials research 2024;28:0076
PR/SET domain 1 targeting glutathione peroxidase 4 regulates chronic hepatitis B liver fibrosis through ferroptosis.
Wu W, Ke W, Shi W, Lin T, Lin S, Lin M, Ma H, Gao H
CytoJournal 2024;21:78
CytoJournal 2024;21:78
Comparative Analysis of the Therapeutic Effects of MSCs From Umbilical Cord, Bone Marrow, and Adipose Tissue and Investigating the Impact of Oxidized RNA on Radiation-Induced Lung Injury.
Zhai R, Tai F, Ding K, Tan X, Li H, Cao Z, Ge C, Zheng X, Fu H
Stem cells international 2024;2024:7419270
Stem cells international 2024;2024:7419270
Combination of Pirfenidone and Andrographolide Ameliorates Hepatic Stellate Cell Activation and Liver Fibrosis by Mediating TGF-β/Smad Signaling Pathway.
Xu G, Ma T, Zhou C, Zhao F, Peng K, Li B
Analytical cellular pathology (Amsterdam) 2024;2024:2751280
Analytical cellular pathology (Amsterdam) 2024;2024:2751280
Hepatobiliary organoids differentiated from hiPSCs relieve cholestasis-induced liver fibrosis in nonhuman primates.
Li H, Li J, Wang T, Sun K, Huang G, Cao Y, Wu F, Xu A
International journal of biological sciences 2024;20(4):1160-1179
International journal of biological sciences 2024;20(4):1160-1179
Irisin ameliorates UUO-induced renal interstitial fibrosis through TGF-β1/periostin/MMP-2 signaling pathway.
Wang Y, Deng X, Wei J, Yang Z, Du Y, Song S, Shi Y, Wu H
PloS one 2024;19(6):e0299389
PloS one 2024;19(6):e0299389
Astragaloside IV alleviates renal fibrosis by inhibiting renal tubular epithelial cell pyroptosis induced by urotensin II through regulating the cAMP/PKA signaling pathway.
Zhang L, Liu W, Li S, Wang J, Sun D, Li H, Zhang Z, Hu Y, Fang J
PloS one 2024;19(5):e0304365
PloS one 2024;19(5):e0304365
TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway.
Zhao X, Zhang J, Xu F, Shang L, Liu Q, Shen C
Open life sciences 2024;19(1):20220957
Open life sciences 2024;19(1):20220957
Combined Placental Mesenchymal Stem Cells with Guided Nanoparticles Effective Against Diabetic Nephropathy in Mouse Model.
Wang K, Liu T, Zhang Y, Lv H, Yao H, Zhao Y, Li J, Li X
International journal of nanomedicine 2024;19:901-915
International journal of nanomedicine 2024;19:901-915
Antioxidant Carbon Dots and Ursolic Acid Co-Encapsulated Liposomes Composite Hydrogel for Alleviating Adhesion Formation and Enhancing Tendon Healing in Tendon Injury.
Peng C, Kang S, Jiang M, Yang M, Gong X
International journal of nanomedicine 2024;19:8709-8727
International journal of nanomedicine 2024;19:8709-8727
Liposomes Loaded with 5-Fluorouracil Can Improve the Efficacy in Pathological Scars.
Li Y, Sun Q, Hao L, Shan H, Jiang Z, Wang Y, Chen Z, Zhu W, Zhao S
International journal of nanomedicine 2024;19:7353-7365
International journal of nanomedicine 2024;19:7353-7365
Nanofabrications of Erythrocyte Membrane-Coated Telmisartan Delivery System Effective for Radiosensitivity of Tumor Cells in Mice Model.
Chen S, Wang C, Meng Y, Li P, Pan Y, He M, Ni X
International journal of nanomedicine 2024;19:1487-1508
International journal of nanomedicine 2024;19:1487-1508
Reduced Proliferative Capacity and Defense against Staphylococcus aureus in Human Nasal Mucosal Epithelium Lacking ZNF365.
Du X, Yu L, Wang L, Yan X, Xu B, Chai F, Li D, Zi J, Zhang J, Jiang Y
International archives of allergy and immunology 2024;185(5):466-479
International archives of allergy and immunology 2024;185(5):466-479
RASSF4 Attenuates Metabolic Dysfunction-Associated Steatotic Liver Disease Progression via Hippo Signaling and Suppresses Hepatocarcinogenesis.
Xu C, Fang T, Qu J, Miao Y, Tian L, Zhang M, Zhuang H, Sun B, Chen L
Cellular and molecular gastroenterology and hepatology 2024;18(2):101348
Cellular and molecular gastroenterology and hepatology 2024;18(2):101348
The Mechanism of Catalpol to Improve Oxidative Damage of Dermal Fibroblasts Based on Nrf2/HO-1 Signaling Pathway.
Lang X, Xu L, Li L, Feng X
Drug design, development and therapy 2024;18:2287-2297
Drug design, development and therapy 2024;18:2287-2297
miR-34b-5p suppresses the epithelial-mesenchymal transition and metastasis in endometrial cancer AN3CA cells by targeting ZEB1.
Shi L, Yang D, Dong H, Zhang X, Yang C
International journal of clinical and experimental pathology 2024;17(4):137-150
International journal of clinical and experimental pathology 2024;17(4):137-150
Claudin-2 Mediates the Proximal Tubular Epithelial Cell-Fibroblast Crosstalk via Paracrine CTGF.
Guo C, Jiao M, Cui Y, Li P, Yao J, Dong J, Liao L
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:55-73
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:55-73
Seed and Soil: Consensus Molecular Subgroups (CMS) and Tumor Microenvironment Features Between Primary Lesions and Metastases of Different Organ Sites in Colorectal Cancer.
Luo Q, Quan Y, Liu W, Wu Z, Qiu W, Liang W, Yang P, Huang Q, Li G, Wei J, Wang Q, Shen F, Li W, He F, Cao J
Cancer management and research 2024;16:225-243
Cancer management and research 2024;16:225-243
Fatty acid synthase inhibition improves hypertension-induced erectile dysfunction by suppressing oxidative stress and NLRP3 inflammasome-dependent pyroptosis through activating the Nrf2/HO-1 pathway.
Luan J, Yu M, Gu Q, Zhou X, Shao Y, Chen T, Zhang J, Zhu Z, Song N, Yang J
Frontiers in immunology 2024;15:1532021
Frontiers in immunology 2024;15:1532021
Qizhu Rougan Granules suppress liver fibrosis by inhibiting the expression of the P2Y14 receptor on hepatic stellate cells.
Tao Y, Niu Q, Yao Y, Wang K, Dong H, Zhao X, Zeng Z, Li H
Frontiers in pharmacology 2024;15:1528100
Frontiers in pharmacology 2024;15:1528100
Yishen paidu pills attenuates 5/6 nephrectomy induced kidney disease via inhibiting the PI3K/AKT/mTOR signaling pathway.
Liu S, Cao Y, Yuan Q, Xie Y, Zhu Y, Yao L, Zhang C
Frontiers in pharmacology 2024;15:1510098
Frontiers in pharmacology 2024;15:1510098
Hypoxia reconstructed colorectal tumor microenvironment weakening anti-tumor immunity: construction of a new prognosis predicting model through transcriptome analysis.
Zhang R, Gao Y, Li C, Tao R, Mao G, Song T, Nie W, Liu S, Tao K, Li W
Frontiers in immunology 2024;15:1425687
Frontiers in immunology 2024;15:1425687
Identification and verification of the optimal feature genes of ferroptosis in thyroid-associated orbitopathy.
Li X, Xiong C, Wang S, Ren Z, Jin Q, Yu J, Chen Y, Gan P, Xu Q, Wang Y, Liao H
Frontiers in immunology 2024;15:1422497
Frontiers in immunology 2024;15:1422497
Thonningianin A ameliorated renal interstitial fibrosis in diabetic nephropathy mice by modulating gut microbiota dysbiosis and repressing inflammation.
Zhang S, Zhang S, Bai X, Wang Y, Liu Y, Liu W
Frontiers in pharmacology 2024;15:1389654
Frontiers in pharmacology 2024;15:1389654
Inhibition of ACOX1 enhances the therapeutic efficacy of obeticholic acid in treating non-alcoholic fatty liver disease and mitigates its lipotoxicity.
Yang Y, Yuan W, He K, Lin C, Du S, Kou Y, Nie B
Frontiers in pharmacology 2024;15:1366479
Frontiers in pharmacology 2024;15:1366479
LINC00982-encoded protein PRDM16-DT regulates CHEK2 splicing to suppress colorectal cancer metastasis and chemoresistance.
Hu HF, Han L, Fu JY, He X, Tan JF, Chen QP, Han JR, He QY
Theranostics 2024;14(8):3317-3338
Theranostics 2024;14(8):3317-3338
HIF2A mediates lineage transition to aggressive phenotype of cancer-associated fibroblasts in lung cancer brain metastasis.
You M, Fu M, Shen Z, Feng Y, Zhang L, Zhu X, Zhuang Z, Mao Y, Hua W
Oncoimmunology 2024;13(1):2356942
Oncoimmunology 2024;13(1):2356942
Twist-related protein 1 promotes transforming growth factor β receptor 1 in keloid fibroblasts via regulating the stability of myocyte enhancer factor 2A.
Li T, Zhang M, Li Y, Sun Y, Huang J, Zeng A, Yu N, Long X
Burns & trauma 2024;12:tkae024
Burns & trauma 2024;12:tkae024
Hypoxia macrophage-derived exosomal miR-26b-5p targeting PTEN promotes the development of keloids.
Dai S, Xu M, Pang Q, Sun J, Lin X, Chu X, Guo C, Xu J
Burns & trauma 2024;12:tkad036
Burns & trauma 2024;12:tkad036
Hsa_circ_0009096/miR-370-3p modulates hepatic stellate cell proliferation and fibrosis during biliary atresia pathogenesis.
Wu Z, Wang B, Chen S, Zuo T, Zhang W, Cheng Z, Fu J, Gong J
PeerJ 2024;12:e17356
PeerJ 2024;12:e17356
Ultra-small curcumin-ruthenium coordination polymer nanodots prevent renal ischemia-reperfusion injury and the progression to chronic kidney disease.
Liu X, Yu Q, Mao HB, Hu JB, Liu WH
Frontiers in bioengineering and biotechnology 2024;12:1506909
Frontiers in bioengineering and biotechnology 2024;12:1506909
The clinical impact of macrophage polarity after Kasai portoenterostomy in biliary atresia.
Nagayabu K, Fumino S, Shimamura A, Sengoku Y, Higashi M, Iguchi M, Aoi S, Saya S, Hirai M, Ogi H, Miyagawa-Hayashino A, Konishi E, Itoh K, Tajiri T, Ono S
Frontiers in pediatrics 2024;12:1338131
Frontiers in pediatrics 2024;12:1338131
Assessment of hypoxia status in a rat chronic liver disease model using IVIM and T1 mapping.
Dong W, Xiao L, Luo Z, Yu H, Wang L, Gao Y, Li Z
Frontiers in medicine 2024;11:1477685
Frontiers in medicine 2024;11:1477685
GSDMB involvement in the pathogenesis of abdominal aortic aneurysm through regulation of macrophage non-canonical pyroptosis.
Xie X, Shen X, Liu Y, Zuo Y, Wang S, Zhou Y, Li X, Wang K, Li B, Wang Z
Archives of biochemistry and biophysics 2024 Sep;759:110102
Archives of biochemistry and biophysics 2024 Sep;759:110102
Enhancing Fat Transplantation Efficiency in a Mouse Model through Pretreatment of Adipose-Derived Stem Cells with RIP3 Inhibitors.
Yang Z, Lu H, Gao Q, Yuan X, Hu Y, Qi Z
Aesthetic plastic surgery 2024 Sep;48(17):3488-3499
Aesthetic plastic surgery 2024 Sep;48(17):3488-3499
Intervention of Asprosin Attenuates Oxidative Stress and Neointima Formation in Vascular Injury.
Zheng F, Ye C, Lei JZ, Ge R, Li N, Bo JH, Chen AD, Zhang F, Zhou H, Wang JJ, Chen Q, Li YH, Zhu GQ, Han Y
Antioxidants & redox signaling 2024 Sep;41(7-9):488-504
Antioxidants & redox signaling 2024 Sep;41(7-9):488-504
Morroniside improves AngII-induced cardiac fibroblast proliferation, migration, and extracellular matrix deposition by blocking p38/JNK signaling pathway through the downregulation of KLF5.
Zheng H, Yang L, Huang H, Lin Y, Chen L
Naunyn-Schmiedeberg's archives of pharmacology 2024 Sep;397(9):6611-6621
Naunyn-Schmiedeberg's archives of pharmacology 2024 Sep;397(9):6611-6621
N6-methyladenosine triggers renal fibrosis via enhancing translation and stability of ZEB2 mRNA.
Cai Y, Zhou J, Xu A, Huang J, Zhang H, Xie G, Zhong K, Wu Y, Ye P, Wang H, Niu H
The Journal of biological chemistry 2024 Sep;300(9):107598
The Journal of biological chemistry 2024 Sep;300(9):107598
Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis.
Song A, Yan R, Xiong W, Xiang H, Huang J, Jiang A, Zhang C
Translational research : the journal of laboratory and clinical medicine 2024 Sep;271:13-25
Translational research : the journal of laboratory and clinical medicine 2024 Sep;271:13-25
Polystyrene microplastics facilitate renal fibrosis through accelerating tubular epithelial cell senescence.
Pan C, Wang X, Fan Z, Mao W, Shi Y, Wu Y, Liu T, Xu Z, Wang H, Chen H
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Sep;191:114888
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Sep;191:114888
Identification of miRNA signature in cancer-associated fibroblast to predict recurrent prostate cancer.
Xu W, Liu S, Ma L, Cheng L, Li Q, Qing L, Yang Y, Dong Z
Computers in biology and medicine 2024 Sep;180:108989
Computers in biology and medicine 2024 Sep;180:108989
Mechanism of Zhenwu Decoction modulating TLR4/NF-κB/HIF-1α loop through miR-451 to delay renal fibrosis in type 2 CRS.
Xu X, Wang Y, Song Q, Zheng H, Lv J, Fu Z, Mao X, Li Y, Wu H, Zhang B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155632
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155632
The role of α7nAchR and PD-L1 in neuroimmune regulation of keloid treatment.
Luo Z, Zheng S, Liu J, Qi F
Cellular signalling 2024 Sep;121:111275
Cellular signalling 2024 Sep;121:111275
Knockdown of programmed cell death factor 4 restores erectile function by attenuating apoptosis in rats with bilateral cavernous nerve crush injury.
Ge Y, Xia T, Feng Z, Xi Y, Hu D, Hong Y, Tang B, Wu J, Chen J, Xiao H
Andrology 2024 Sep;12(6):1439-1448
Andrology 2024 Sep;12(6):1439-1448
Obstructive Sleep Apnea Syndrome Exacerbates NASH Progression via Selective Autophagy-Mediated Eepd1 Degradation.
Xiong J, Xu Y, Wang N, Wang S, Zhang Y, Lu S, Zhang X, Liang X, Liu C, Jiang Q, Xu J, Qian Q, Zhou P, Yin L, Liu F, Chen S, Yin S, Liu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(35):e2405955
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(35):e2405955
Uremic Toxin Receptor AhR Facilitates Renal Senescence and Fibrosis via Suppressing Mitochondrial Biogenesis.
Xie H, Yang N, Lu L, Sun X, Li J, Wang X, Guo H, Zhou L, Liu J, Wu H, Yu C, Zhang W, Lu L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(33):e2402066
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Sep;11(33):e2402066
Acteoside delays the fibrosis process of diabetic nephropathy by anti-oxidation and regulating the autophagy-lysosome pathway.
Zhou M, Zhang S, Bai X, Cai Y, Zhang Z, Zhang P, Xue C, Zheng H, Sun Q, Han D, Lou L, Wang Y, Liu W
European journal of pharmacology 2024 Sep 5;978:176715
European journal of pharmacology 2024 Sep 5;978:176715
3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration.
Yao K, Hong G, Yuan X, Kong W, Xia P, Li Y, Chen Y, Liu N, He J, Shi J, Hu Z, Zhou Y, Xie Z, He Y
Nano-micro letters 2024 Sep 29;17(1):27
Nano-micro letters 2024 Sep 29;17(1):27
Identification of common biomarkers in diabetic kidney disease and cognitive dysfunction using machine learning algorithms.
Peng J, Yang S, Zhou C, Qin C, Fang K, Tan Y, Da J, Zhang J, Zha Y
Scientific reports 2024 Sep 27;14(1):22057
Scientific reports 2024 Sep 27;14(1):22057
GQ262 Attenuates Pathological Cardiac Remodeling by Downregulating the Akt/mTOR Signaling Pathway.
Ma H, Ge Y, Di C, Wang X, Qin B, Wang A, Hu W, Lai Z, Xiong X, Qi R
International journal of molecular sciences 2024 Sep 25;25(19)
International journal of molecular sciences 2024 Sep 25;25(19)
Cancer-associated fibroblast-derived exosome Leptin promotes malignant biological lineage in pancreatic ductal adenocarcinoma by regulating ABL2 via miR-224-3p.
Zhang L, Chen Y, Dai Y, Mou W, Deng P, Jin Y, Xu J, Jin Y
Molecular biology reports 2024 Sep 19;51(1):995
Molecular biology reports 2024 Sep 19;51(1):995
Deficiency of geranylgeranyl biphosphate synthase in kidney tubules causes cystic kidney disease.
Shao X, Wang K, Wu J, Ma X, Zhao Y, Xu T, Dai C, Zhang F, Wang Y, Ren X, Lu K, Yin Z, Guo B, Cao C, Xu X, Xue B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 15;38(17):e23875
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 15;38(17):e23875
Exosome miRNA profile and mitigating effect of miR-23a-3p/Cul3 axis on apoptosis in the pathogenesis of SiO(2) dust-induced lung fibrosis.
Chang S, Xie W, Qu H, Ban J, Ma P, Fei S, Liu F
Ecotoxicology and environmental safety 2024 Sep 15;283:116971
Ecotoxicology and environmental safety 2024 Sep 15;283:116971
Early inhibition of BRD4 facilitates iPSC reprogramming via accelerating rDNA dynamic expression.
Zhang Z, Hu X, Sun Y, Lei L, Liu Z
BMC biology 2024 Sep 11;22(1):195
BMC biology 2024 Sep 11;22(1):195
Endosialin-positive CAFs promote hepatocellular carcinoma progression by suppressing CD8(+) T cell infiltration.
Gan L, Lu T, Lu Y, Song H, Zhang J, Zhang K, Lu S, Wu X, Nie F, Di S, Han D, Yang F, Qin W, Wen W
Journal for immunotherapy of cancer 2024 Sep 10;12(9)
Journal for immunotherapy of cancer 2024 Sep 10;12(9)
Insulin-transferrin-selenium promote formation of tissue-engineered vascular grafts in early stage of culture.
Sun X, Wang N, Jiang H, Liu Q, Xiao C, Xu J, Wu Y, Mei J, Wu S, Lin Z
Preparative biochemistry & biotechnology 2024 Oct;54(9):1186-1195
Preparative biochemistry & biotechnology 2024 Oct;54(9):1186-1195
Toll-Like Receptor 9 Aggravates Pulmonary Fibrosis by Promoting NLRP3-Mediated Pyroptosis of Alveolar Epithelial Cells.
Ren C, Wang Q, Fan S, Mi T, Zhang Z, He D
Inflammation 2024 Oct;47(5):1744-1761
Inflammation 2024 Oct;47(5):1744-1761
Target NF-κB p65 for preventing posttraumatic joint contracture in rats.
Kong L, Liang Y, Hou J, Zhang W, Jiang S
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2024 Oct;42(10):2172-2180
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2024 Oct;42(10):2172-2180
Novel glucomannan-like polysaccharide from Lycium barbarum L. ameliorates renal fibrosis via blocking macrophage-to-myofibroblasts transition.
Liu T, Zhang Y, Wu Z, Zhao CJ, Dong X, Gong HX, Jin B, Han MM, Wu JJ, Fan YK, Li N, Xiong YX, Zhang ZQ, Dong ZQ
International journal of biological macromolecules 2024 Oct;278(Pt 2):134491
International journal of biological macromolecules 2024 Oct;278(Pt 2):134491
Urine-Derived Stem Cells Reverse Bleomycin‑Induced Experimental Pulmonary Fibrosis by Inhibition of the TGF-β1-Smad2/3 Pathway.
Zhang Y, Xia Y, Zhang R, Zhou X, Jiang J
Cytotherapy 2024 Oct;26(10):1236-1244
Cytotherapy 2024 Oct;26(10):1236-1244
Regulation of Fuzheng Huayu capsule on inhibiting the fibrosis-associated hepatocellular carcinogenesis.
Zhang WQ, Sun JX, Lan ST, Sun XM, Guo YJ, Wen BC, Chen J, Liu G
Journal of Asian natural products research 2024 Oct;26(10):1219-1238
Journal of Asian natural products research 2024 Oct;26(10):1219-1238
Gentiana decoction inhibits liver fibrosis and the activation of hepatic stellate cells via upregulating the expression of Parkin.
Deng J, Long J, Yang Y, Yang F, Wei Y
Fitoterapia 2024 Oct;178:106170
Fitoterapia 2024 Oct;178:106170
Cinnamaldehyde activates AMPK/PGC-1α pathway via targeting GRK2 to ameliorate heart failure.
Xu Z, Li M, Lyu D, Xiao H, Li S, Li Z, Li M, Xiao J, Huang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155894
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155894
Neutrophil-Mediated Nanozyme Delivery System for Acute Kidney Injury Therapy.
Yang Y, Du J, Gan J, Song X, Shu J, An C, Lu L, Wei H, Che J, Zhao X
Advanced healthcare materials 2024 Oct;13(26):e2401198
Advanced healthcare materials 2024 Oct;13(26):e2401198
LncRNA CCAT2 Knockdown Alleviates Pressure Overload or Ang II-Induced Cardiac Hypertrophy Via Disruption of the Wnt/β-Catenin Signaling.
Zhang X, Chen Z, Zhang N, Yu B, Li W, Zhang M, Wu X, Liu G, Dong M
Arquivos brasileiros de cardiologia 2024 Oct;121(10):e20240181
Arquivos brasileiros de cardiologia 2024 Oct;121(10):e20240181
Targeting Bacteria-Induced Ferroptosis of Bone Marrow Mesenchymal Stem Cells to Promote the Repair of Infected Bone Defects.
Yuan K, Yang Y, Lin Y, Zhou F, Huang K, Yang S, Kong W, Li F, Kan T, Wang Y, Cheng C, Liang Y, Chang H, Huang J, Ao H, Yu Z, Li H, Liu Y, Tang T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(39):e2404453
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(39):e2404453
Polymeric immunoglobulin receptor promotes Th2 immune response in the liver by increasing cholangiocytes derived IL-33: a diagnostic and therapeutic biomarker of biliary atresia.
Li Y, Li TY, Qiao Q, Zhang MT, Tong MX, Xu LF, Zhang ZB
EBioMedicine 2024 Oct;108:105344
EBioMedicine 2024 Oct;108:105344
SMYD2 Promotes Calcium Oxalate-Induced Glycolysis in Renal Tubular Epithelial Cells via PTEN Methylation.
Pan S, Yuan T, Xia Y, Yu W, Li H, Rao T, Ye Z, Li L, Zhou X, Cheng F
Biomedicines 2024 Oct 8;12(10)
Biomedicines 2024 Oct 8;12(10)
Vitamin D receptor attenuates carbon tetrachloride-induced liver fibrosis via downregulation of YAP.
Wang P, Li J, Ji M, Pan J, Cao Y, Kong Y, Zhu L, Li J, Li B, Chang L, Zhang Z
Journal of hazardous materials 2024 Oct 5;478:135480
Journal of hazardous materials 2024 Oct 5;478:135480
Transcriptomic analysis reveals the critical role of chemokine signaling in the anti-atherosclerosis effect of Xuefu Zhuyu decoction.
Jia D, Zhao M, Zhang X, Cheng X, Wei Q, Lou L, Zhao Y, Jin Q, Chen M, Zhang D
Journal of ethnopharmacology 2024 Oct 5;332:118245
Journal of ethnopharmacology 2024 Oct 5;332:118245
The senolytic drug ABT-263 accelerates ovarian aging in older female mice.
Xia X, Yang Y, Liu P, Chen L, Dai X, Xue P, Wang Y
Scientific reports 2024 Oct 5;14(1):23178
Scientific reports 2024 Oct 5;14(1):23178
LncRNA FEZF1-AS1 promotes pulmonary fibrosis via up-regulating EZH2 and targeting miR-200c-3p to regulate the ZEB1 pathway.
Liu M, Song L, Lai Y, Gao F, Man J
Scientific reports 2024 Oct 30;14(1):26044
Scientific reports 2024 Oct 30;14(1):26044
Quantitative proteomics reveals the mechanism of endoplasmic reticulum stress-mediated pulmonary fibrosis in mice.
Li H, Wang J, Li Z, Wu Z, Zhang Y, Kong L, Yang Q, Wang D, Shi H, Shen G, Zou S, Zhu W, Fan K, Xu Z
Heliyon 2024 Oct 30;10(20):e39150
Heliyon 2024 Oct 30;10(20):e39150
The Toll-like receptor 4 antagonist TAK-242 in combination with sodium hyaluronate alleviates postoperative abdominal adhesion in a mouse model.
Liu D, Tong H, Guo Y, Liu B, Ye C, Yang N, Wu Y
BMC medical genomics 2024 Oct 25;17(1):257
BMC medical genomics 2024 Oct 25;17(1):257
Autophagy activation ameliorates the fibrosis of trabecular meshwork cells induced by TGFβ2 through the promotion of fibrotic proteins degradation.
Wang G, Zhao R, Guo Z, Cui H, Wang D, Ren J, Zhu S, Zhang K, Tang B, Zhang J, Li P, Duan S, Li H
Human cell 2024 Oct 22;38(1):4
Human cell 2024 Oct 22;38(1):4
GLP-1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome/PFKFB3-driven glycolysis interaction and histone lactylation.
Liu C, Zhang Q, Zhou H, Jin L, Liu C, Yang M, Zhao X, Ding W, Xie W, Kong H
Journal of translational medicine 2024 Oct 21;22(1):954
Journal of translational medicine 2024 Oct 21;22(1):954
Nasal instillation of polystyrene nanoplastics induce lung injury via mitochondrial DNA release and activation of the cyclic GMP-AMP synthase-stimulator of interferon genes-signaling cascade.
Liu J, Xu F, Guo M, Gao D, Song Y
The Science of the total environment 2024 Oct 20;948:174674
The Science of the total environment 2024 Oct 20;948:174674
Nr-CWS regulates METTL3-mediated m(6)A modification of CDS2 mRNA in vascular endothelial cells and has prognostic significance.
Zhang J, Chen F, Wei W, Ning Q, Zhu D, Fan J, Wang H, Wang J, Zhang A, Jin P, Li Q
Communications biology 2024 Oct 18;7(1):1348
Communications biology 2024 Oct 18;7(1):1348
MiR-1307-5p enhances fibroblast transdifferentiation to exacerbate chronic obstructive pulmonary disease through regulating FBXL16/HIF1α axis.
Yao LP, Wang ZK, Jiang XQ, Jiang B, Chen SJ, Hua ZD, Gao DD, Zheng Q, Zhu SM, Qian MX, Zhang F, Xu LF, Chen CS, Lu F
Respiratory research 2024 Oct 17;25(1):376
Respiratory research 2024 Oct 17;25(1):376
NLRP3 inflammasome inhibition decreases Schistosomiasis japonica-induced granulomatous inflammation and fibrosis in BALB/c mice.
Lu Y, Liu J, Tang W, Zhang H
Infection and immunity 2024 Oct 15;92(10):e0005524
Infection and immunity 2024 Oct 15;92(10):e0005524
Novel Insight into the mechanism of di (2-ethylhexyl) phthalate (DEHP) impairing early follicle development.
Feng M, Wang J, Zhao X, Du H, Dai Y
Ecotoxicology and environmental safety 2024 Oct 15;285:117043
Ecotoxicology and environmental safety 2024 Oct 15;285:117043
NIR-II light based combinatorial management of hypertrophic scar by inducing autophagy in fibroblasts.
Dong Y, Wang H, Zhang Y, Wu Y, Lu L, Yu H, Zhou L, Zhao P, Ouyang S, Song Z, Hu Z, Lv D, Rong Y, Zhao Z, Tao J, Tang B, Luo S
Journal of nanobiotechnology 2024 Oct 15;22(1):625
Journal of nanobiotechnology 2024 Oct 15;22(1):625
A proteomics-based study of the mechanism of oxymatrine to ameliorate hepatic fibrosis in mice.
Wu J, Jin X, Li W, Liu E
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2024 Oct 15;1247:124280
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2024 Oct 15;1247:124280
Nesfatin-1 enhances vascular smooth muscle calcification through facilitating BMP-2 osteogenic signaling.
Zhu XX, Meng XY, Chen G, Su JB, Fu X, Xu AJ, Liu Y, Hou XH, Qiu HB, Sun QY, Hu JY, Lv ZL, Sun HJ, Jiang HB, Han ZJ, Zhu J, Lu QB
Cell communication and signaling : CCS 2024 Oct 11;22(1):488
Cell communication and signaling : CCS 2024 Oct 11;22(1):488
Deubiquitinase USP18 inhibits hepatic stellate cells activation and alleviates liver fibrosis via regulation of TAK1 activity.
Zhang Y, Gao J, Liu Y, Zhong L, He S, Qiu C
Experimental cell research 2024 Oct 1;442(2):114235
Experimental cell research 2024 Oct 1;442(2):114235
Triclosan exposure causes abnormal bile acid metabolism through IL-1β-NF-κB-Fxr signaling pathway.
Liu J, Xu F, Guo M, Song Y
Ecotoxicology and environmental safety 2024 Oct 1;284:116989
Ecotoxicology and environmental safety 2024 Oct 1;284:116989
FOXO1-mTOR pathway in vascular pericyte regulates the formation of type H vessels to control bone metabolism.
Cheng C, Deng M, Cheng C, Wu H, Wang Y, Lu M, Yao Z, Li K, Zhang X, Yu B
Journal of orthopaedic translation 2024 Nov;49:246-263
Journal of orthopaedic translation 2024 Nov;49:246-263
TRIM65 deficiency alleviates renal fibrosis through NUDT21-mediated alternative polyadenylation.
Wei S, Huang X, Zhu Q, Chen T, Zhang Y, Tian J, Pan T, Zhang L, Xie T, Zhang Q, Kuang X, Lei E, Li Y
Cell death and differentiation 2024 Nov;31(11):1422-1438
Cell death and differentiation 2024 Nov;31(11):1422-1438
The pH-sensitive chondroitin sulphate-based nanoparticles for co-delivery of doxorubicin and berberine enhance the treatment of breast cancer.
Wu J, Li Y, Sun S, Li W, Sun J, Zhu L, Wang Z, Yang F, Wang Q, Ding H, Ding X, Guo Z
International journal of biological macromolecules 2024 Nov;281(Pt 4):136484
International journal of biological macromolecules 2024 Nov;281(Pt 4):136484
Three-dimensional bioprinted cell-adaptive hydrogel with anisotropic micropores for enhancing skin wound healing.
Shi B, Zhu T, Luo Y, Zhang X, Yao J, Cao X, Zhu Y, Miao H, Li L, Song Q, Zhang H, Xu L
International journal of biological macromolecules 2024 Nov;280(Pt 4):136106
International journal of biological macromolecules 2024 Nov;280(Pt 4):136106
Early growth response 1 exacerbates thoracic aortic aneurysm and dissection of mice by inducing the phenotypic switching of vascular smooth muscle cell through the activation of Krüppel-like factor 5.
Han X, Xu S, Hu K, Yu Y, Wang X, Qu C, Yang B, Liu X
Acta physiologica (Oxford, England) 2024 Nov;240(11):e14237
Acta physiologica (Oxford, England) 2024 Nov;240(11):e14237
Hepatotoxic assessment in a microphysiological system: Simulation of the drug absorption and toxic process after an overdosed acetaminophen on intestinal-liver-on-chip.
Yu Y, Sun B, Ye X, Wang Y, Zhao M, Song J, Geng X, Marx U, Li B, Zhou X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Nov;193:115016
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Nov;193:115016
Luteolin detoxifies DEHP and prevents liver injury by degrading Uroc1 protein in mice.
Wang H, Zhao Z, Song M, Zhang W, Liu C, Chen S
EMBO molecular medicine 2024 Nov;16(11):2699-2724
EMBO molecular medicine 2024 Nov;16(11):2699-2724
Fusion protein of FGF21 and elastin-like peptide improves wound healing in diabetic mice via inflammation modulation, collagen synthesis, and vascular network formation.
Xiong F, Jiang X, Wu Y, Xiong J, Chen Y, Wang B, Ye X, Liang X
European journal of pharmacology 2024 Nov 5;982:176953
European journal of pharmacology 2024 Nov 5;982:176953
Targeting GPR39 in structure-based drug discovery reduces Ang II-induced hypertension.
Hua D, Huang W, Xie Q, Xu W, Tang L, Liu M, Wu X, Zhang Q, Cao X, Li P, Sheng Y
Communications biology 2024 Nov 5;7(1):1441
Communications biology 2024 Nov 5;7(1):1441
Harnessing the regenerative effects of human amniotic stem cells (hAFSCs) on restoring erectile function in a bilateral cavernous nerve crush (BCNC) injury rat model.
Liao CH, Tseng XW, Rajneesh CP, Chang YJ, Tsai MS, Hsu WC, Chen KC, Wu YN
Stem cell research & therapy 2024 Nov 5;15(1):400
Stem cell research & therapy 2024 Nov 5;15(1):400
Involvement of Melatonin, Oxidative Stress, and Inflammation in the Protective Mechanism of the Carotid Artery over the Torpor-Arousal Cycle of Ground Squirrels.
Hao Z, Han Y, Zhao Q, Zhu M, Liu X, Yang Y, An N, He D, Lefai E, Storey KB, Chang H, Xie M
International journal of molecular sciences 2024 Nov 29;25(23)
International journal of molecular sciences 2024 Nov 29;25(23)
Impact of mesenchymal stem cell size and adhesion modulation on in vivo distribution: insights from quantitative PET imaging.
Ji X, Wang L, Zhong Y, Xu Q, Yan J, Pan D, Xu Y, Chen C, Wang J, Wang G, Yang M, Li T, Tang L, Wang X
Stem cell research & therapy 2024 Nov 28;15(1):456
Stem cell research & therapy 2024 Nov 28;15(1):456
Excessive Supplement of l-Arginine Induces Myopia via Orchestrating the MEK-ERK-NO Signaling Pathway.
Bao B, Liu J, Xin J, Zhou X, Zhang R, Hao J, Yang Z, Zhang M, Ma Z, Yin X, Bi H, Guo D
Journal of agricultural and food chemistry 2024 Nov 27;72(47):26462-26474
Journal of agricultural and food chemistry 2024 Nov 27;72(47):26462-26474
Target-Engineered Liposomes Decorated with Nanozymes Alleviate Liver Fibrosis by Remodeling the Liver Microenvironment.
Yang D, Liu K, Cai C, Xi J, Yan C, Peng Z, Wang Y, Jing L, Zhang Y, Xie F, Li X
ACS applied materials & interfaces 2024 Nov 27;16(47):64536-64553
ACS applied materials & interfaces 2024 Nov 27;16(47):64536-64553
ANGPTL4 promotes choroidal neovascularization and subretinal fibrosis through the endothelial‒mesenchymal transition.
Chen J, Yang Y, Su S, Zhang S, Huang J, Chen H, Yang X, Sang A
International ophthalmology 2024 Nov 26;44(1):441
International ophthalmology 2024 Nov 26;44(1):441
DsbA-L activates TGF-β1/SMAD3 signaling and M2 macrophage polarization by stimulating AKT1 and NLRP3 to promote pulmonary fibrosis.
Wang J, Xia Z, Qing B, Chen Y, Gu L, Chen H, Ge Z, Yuan Y
Molecular medicine (Cambridge, Mass.) 2024 Nov 23;30(1):228
Molecular medicine (Cambridge, Mass.) 2024 Nov 23;30(1):228
Gastrodin attenuates diabetic cardiomyopathy characterized by myocardial fibrosis by inhibiting the KLK8-PAR1 signaling axis.
Zhang M, Zhang Y, He J, Wang X, Wang Y, Li L, Tao L, Zhang M, Shen X
Chinese medicine 2024 Nov 22;19(1):164
Chinese medicine 2024 Nov 22;19(1):164
Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis.
Zhang Y, Wu R, Zhan X, Wang XY, Xiang LW, Duan YQ, You Y, Zhang JB, Wu R, Zhang YY, Duan L
Cell communication and signaling : CCS 2024 Nov 20;22(1):556
Cell communication and signaling : CCS 2024 Nov 20;22(1):556
NOTCH1 mitochondria localization during heart development promotes mitochondrial metabolism and the endothelial-to-mesenchymal transition in mice.
Wang J, Zhao R, Xu S, Zhou XY, Cai K, Chen YL, Zhou ZY, Sun X, Shi Y, Wang F, Gui YH, Tao H, Zhao JY
Nature communications 2024 Nov 16;15(1):9945
Nature communications 2024 Nov 16;15(1):9945
Ulinastatin attenuates renal fibrosis by regulating AMPK/HIF-1α signaling pathway-mediated glycolysis.
Wei X, Long M, Fan Z, Hou Y, Yang L, Du Y
Scientific reports 2024 Nov 14;14(1):28032
Scientific reports 2024 Nov 14;14(1):28032
Mechanics-activated fibroblasts promote pulmonary group 2 innate lymphoid cell plasticity propelling silicosis progression.
He Y, Yang F, Yang L, Yuan H, You Y, Chen Y, Wu X, Min H, Chen J, Li C
Nature communications 2024 Nov 12;15(1):9770
Nature communications 2024 Nov 12;15(1):9770
Extracellular matrix protein 1 binds to connective tissue growth factor against liver fibrosis and ductular reaction.
Sun C, Fan W, Basha S, Tian T, Jin-Smith B, Barkin J, Xie H, Zhou J, Yin XM, Ling C, Sun B, Petersen B, Pi L
Hepatology communications 2024 Nov 1;8(11)
Hepatology communications 2024 Nov 1;8(11)
Gaudichaudione H ameliorates liver fibrosis and inflammation by targeting NRF2 signaling pathway.
Shi M, Guo Y, Xu J, Yan L, Li X, Liu R, Feng Y, Zhang Y, Zhao Y, Zhang C, Du K, Li M, Zhang Y, Zhang J, Li Z, Ren D, Liu P
Free radical biology & medicine 2024 Nov 1;224:770-784
Free radical biology & medicine 2024 Nov 1;224:770-784
Synergistic anticancer effects of ginsenoside CK and gefitinib against gefitinib-resistant NSCLC by regulating the balance of angiogenic factors through HIF-1α/VEGF.
Song X, Wang L, Cai P, Xu Y, Liu Q, Fan D
Toxicology and applied pharmacology 2024 May;486:116938
Toxicology and applied pharmacology 2024 May;486:116938
Mangiferin alleviates diabetic pulmonary fibrosis in mice via inhibiting endothelial-mesenchymal transition through AMPK/FoxO3/SIRT3 axis.
Fu TL, Li GR, Li DH, He RY, Liu BH, Xiong R, Xu CZ, Lu ZL, Song CK, Qiu HL, Wang WJ, Zou SS, Yi K, Li N, Geng Q
Acta pharmacologica Sinica 2024 May;45(5):1002-1018
Acta pharmacologica Sinica 2024 May;45(5):1002-1018
Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis.
Li X, Chen Y, Lu R, Hu M, Gu L, Huang Q, Meng W, Zhu H, Fan C, Zhou Z, Mo X
Oncogene 2024 May;43(20):1506-1521
Oncogene 2024 May;43(20):1506-1521
Dihydrocapsaicin suppresses the STING-mediated accumulation of ROS and NLRP3 inflammasome and alleviates apoptosis after ischemia-reperfusion injury of perforator skin flap.
Lai Y, Yang N, Chen X, Ma X, Chen Z, Dong C, Yu G, Huang Y, Shi D, Fang P, Fu K, Jiang R, Mao C, Ding J, Gao W
Phytotherapy research : PTR 2024 May;38(5):2539-2559
Phytotherapy research : PTR 2024 May;38(5):2539-2559
Lacosamide alleviates bilateral cavernous nerve injury-induced erectile dysfunction in the rat model by ameliorating pathological changes in the corpus cavernosum.
Yao L, Cong R, Zhou X, Zhou X, Ji C, Wei X, Meng X, Song N
International journal of impotence research 2024 May;36(3):283-290
International journal of impotence research 2024 May;36(3):283-290
The Jagged-1/Notch1 Signaling Pathway Promotes the Construction of Tissue-Engineered Heart Valves.
Liu K, Wei ZY, Zhong XH, Liu X, Chen H, Pan Y, Zeng W
Tissue engineering. Part A 2024 May;30(9-10):381-392
Tissue engineering. Part A 2024 May;30(9-10):381-392
Sirt7/HIC1 complex participates in hyperglycaemia-mediated EndMT via modulation of SDC1 expression in diabetic kidney disease and metabolic memory.
Lu L, Zhu M, Wu Q, Sun Z, Chen X, Miao C
Journal of cellular and molecular medicine 2024 May;28(9):e18336
Journal of cellular and molecular medicine 2024 May;28(9):e18336
Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid-derived suppressor cells.
Gu X, Zhang L, Sun M, Zhou Y, Ji J, Xu Y, You J, Deng Z
Journal of cellular and molecular medicine 2024 May;28(9):e18310
Journal of cellular and molecular medicine 2024 May;28(9):e18310
Analysis of the effects of M2 macrophage-derived PDE4C on the prognosis, metastasis and immunotherapy benefit of osteosarcoma.
Pan F, Pan R, Hu R, Zhang H, Lei S, Zhang L, Zhou C, Zeng Z, Tian X, Xie Q
Journal of cellular and molecular medicine 2024 May;28(10):e18395
Journal of cellular and molecular medicine 2024 May;28(10):e18395
Inhibition of STAT3 by S3I-201 suppress peritoneal fibroblast phenotype conversion and alleviate peritoneal fibrosis.
Song Q, Li H, Yan H, Yu Z, Li Z, Yuan J, Jiang N, Ni Z, Gu L, Fang W
Journal of cellular and molecular medicine 2024 May;28(10):e18381
Journal of cellular and molecular medicine 2024 May;28(10):e18381
CNPY2 governs PDGF‑BB‑treated vascular smooth muscle cell proliferation, migration and phenotypic transformation via the Akt/mTOR/GSK‑3β signaling pathway.
Sun H, Wang X, Ma L, Li X, Jin W, Yang Y
Experimental and therapeutic medicine 2024 May;27(5):197
Experimental and therapeutic medicine 2024 May;27(5):197
Riboflavin protects against pancreatic cancer metastasis by targeting TGF-β receptor 1.
Zhao J, Liu X, Jin X, Dong T, Gao X, Wang J, Li Y, Ma E
Bioorganic chemistry 2024 May;146:107274
Bioorganic chemistry 2024 May;146:107274
Paris polyphylla ethanol extract and polyphyllin I ameliorate adenomyosis by inhibiting epithelial-mesenchymal transition.
Shi YX, Xu L, Wang X, Zhang KK, Zhang CY, Liu HY, Ding PP, Shi W, Liu ZY
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155461
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155461
Loss of PBX1 function in Leydig cells causes testicular dysgenesis and male sterility.
Wang FC, Zhang XN, Wu SX, He Z, Zhang LY, Yang QE
Cellular and molecular life sciences : CMLS 2024 May 9;81(1):212
Cellular and molecular life sciences : CMLS 2024 May 9;81(1):212
Midkine promotes renal fibrosis by stabilizing C/EBPβ to facilitate endothelial-mesenchymal transition.
Xu C, Chen J, Liang L, Chen S, Niu X, Sang R, Yang C, Rong R
Communications biology 2024 May 7;7(1):544
Communications biology 2024 May 7;7(1):544
Effects of Nanoparticle-Mediated Dihydromyricetin to Diabetic Wounds: An In Vivo Study.
Wang ZN, Ma JC, Xi MF, Yin D, Jiang LF, Qi J
Journal of burn care & research : official publication of the American Burn Association 2024 May 6;45(3):644-654
Journal of burn care & research : official publication of the American Burn Association 2024 May 6;45(3):644-654
Naringenin reduces oxidative stress and necroptosis, apoptosis, and pyroptosis in random-pattern skin flaps by enhancing autophagy.
Jiang S, Ma F, Lou J, Li J, Shang X, Li Y, Wu J, Xu S
European journal of pharmacology 2024 May 5;970:176455
European journal of pharmacology 2024 May 5;970:176455
Inhibition of OGG1 ameliorates pulmonary fibrosis via preventing M2 macrophage polarization and activating PINK1-mediated mitophagy.
Wu W, Jia H, Chen S, Ma X, Zhou S, Qiu L, Wu X, Li P, Chu H, Zhang G
Molecular medicine (Cambridge, Mass.) 2024 May 31;30(1):72
Molecular medicine (Cambridge, Mass.) 2024 May 31;30(1):72
Lipotoxic hepatocyte derived LIMA1 enriched small extracellular vesicles promote hepatic stellate cells activation via inhibiting mitophagy.
Li S, Yang F, Cheng F, Zhu L, Yan Y
Cellular & molecular biology letters 2024 May 31;29(1):82
Cellular & molecular biology letters 2024 May 31;29(1):82
Senegenin Attenuates Pulmonary Fibrosis by Inhibiting Oxidative-Stress-Induced Epithelial Cell Senescence through Activation of the Sirt1/Pgc-1α Signaling Pathway.
Zeng Q, Luo Y, Sang X, Liao M, Wen B, Hu Z, Sun M, Luo Z, Huang X, Liu W, Tang S
Antioxidants (Basel, Switzerland) 2024 May 31;13(6)
Antioxidants (Basel, Switzerland) 2024 May 31;13(6)
Inducible Fgf13 ablation alleviates cardiac fibrosis via regulation of microtubule stability.
Wang C, Wang X, Zhang Y, Mi Y, Han Y, Zhi Y, Zhao R, Cui N, Ma Q, Zhang H, Xue D, Qiao R, Han J, Yu Y, Li J, Shaiea M, Liu D, Gu G, Wang C
Acta biochimica et biophysica Sinica 2024 May 30;56(12):1802-1812
Acta biochimica et biophysica Sinica 2024 May 30;56(12):1802-1812
CXCL4:NLRP3-mediated pyroptosis product that regulates cardiac fibrosis.
Wei J, Peng MY, Wang SN, Lu HX
International immunopharmacology 2024 May 30;133:112096
International immunopharmacology 2024 May 30;133:112096
CD47, a novel YAP target gene, contributes to hepatic stellate cell activation and liver fibrosis induced by high-fat diet.
Li Y, Dong L, Yin X, Wang X, Zhu X, Zheng P, Tang Y
Heliyon 2024 May 30;10(10):e31621
Heliyon 2024 May 30;10(10):e31621
Podocyte-Specific Deletion of MCP-1 Fails to Protect against Angiotensin II- or Adriamycin-Induced Glomerular Disease.
Bondi CD, Hartman HL, Rush BM, Tan RJ
International journal of molecular sciences 2024 May 3;25(9)
International journal of molecular sciences 2024 May 3;25(9)
Exosomes derived from adipose tissue-derived stem cells alleviated H(2)O(2)-induced oxidative stress and endothelial-to-mesenchymal transition in human umbilical vein endothelial cells by inhibition of the mir-486-3p/Sirt6/Smad signaling pathway.
Li Y, Xiao Y, Shang Y, Xu C, Han C, Hu D, Han J, Wang H
Cell biology and toxicology 2024 May 25;40(1):39
Cell biology and toxicology 2024 May 25;40(1):39
Astragalus polysaccharides augment BMSC homing via SDF-1/CXCR4 modulation: a novel approach to counteract peritoneal mesenchymal transformation and fibrosis.
Wang F, Dai H, Zhou Z, Shan Y, Yu M, Sun J, Sheng L, Huang L, Meng X, You Y, Sheng M
BMC complementary medicine and therapies 2024 May 24;24(1):204
BMC complementary medicine and therapies 2024 May 24;24(1):204
Design, Synthesis, and Evaluation of Dihydropyrimidine Derivatives as Selective PDE1 Inhibitors for the Treatment of Liver Fibrosis.
Zhao ZJ, Jiang MY, Huang MX, Yang YY, Feng LL, Zhang C, Huang YY, Luo HB, Wu Y
Journal of medicinal chemistry 2024 May 23;67(10):8309-8322
Journal of medicinal chemistry 2024 May 23;67(10):8309-8322
Modeling alcohol-associated liver disease in humans using adipose stromal or stem cell-derived organoids.
Bi G, Zhang X, Li W, Lu X, He X, Li Y, Bai R, Zhang H
Cell reports methods 2024 May 20;4(5):100778
Cell reports methods 2024 May 20;4(5):100778
MicroRNA-142-3p alleviated high salt-induced cardiac fibrosis via downregulating optineurin-mediated mitophagy.
Li Y, Zhao K, Hu Y, Yang F, Li P, Liu Y
iScience 2024 May 17;27(5):109764
iScience 2024 May 17;27(5):109764
MiRNA-145-5p inhibits gastric cancer progression via the serpin family E member 1- extracellular signal-regulated kinase-1/2 axis.
Bai HX, Qiu XM, Xu CH, Guo JQ
World journal of gastrointestinal oncology 2024 May 15;16(5):2123-2140
World journal of gastrointestinal oncology 2024 May 15;16(5):2123-2140
Enhanced Vascular-like Network Formation of Encapsulated HUVECs and ADSCs Coculture in Growth Factors Conjugated GelMA Hydrogels.
Bupphathong S, Lim J, Fang HW, Tao HY, Yeh CE, Ku TA, Huang W, Kuo TY, Lin CH
ACS biomaterials science & engineering 2024 May 13;10(5):3306-3315
ACS biomaterials science & engineering 2024 May 13;10(5):3306-3315
Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.
Wang FR, Peng ML, Zhu QF, Yu LL, Zhang LJ, Xu SY, Wang Q, Li J, He X, Liao SG, Ao JL, Xu GB
Journal of ethnopharmacology 2024 May 10;325:117830
Journal of ethnopharmacology 2024 May 10;325:117830
The SP1/SIRT1/ACLY signaling axis mediates fatty acid oxidation in renal ischemia-reperfusion-induced renal fibrosis.
Wu H, Wang L, Kang P, Zhou X, Li W, Xia Z
International immunopharmacology 2024 May 10;132:112002
International immunopharmacology 2024 May 10;132:112002
SIRT1 activation ameliorates rhesus monkey liver fibrosis by inhibiting the TGF-β/smad signaling pathway.
Xia Y, Luo Q, Gao Q, Huang C, Chen P, Zou Y, Chen X, Liu W, Chen Z
Chemico-biological interactions 2024 May 1;394:110979
Chemico-biological interactions 2024 May 1;394:110979
Echinacoside Exerts Antihepatic Fibrosis Effects in High-Fat Mice Model by Modulating the ACVR2A-Smad Pathway.
Liang J, Chen T, Xu H, Wang T, Gong Q, Li T, Liu X, Wang J, Wang Y, Xiong L
Molecular nutrition & food research 2024 Mar;68(6):e2300553
Molecular nutrition & food research 2024 Mar;68(6):e2300553
Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression.
Hu J, Wang SG, Hou Y, Chen Z, Liu L, Li R, Li N, Zhou L, Yang Y, Wang L, Wang L, Yang X, Lei Y, Deng C, Li Y, Deng Z, Ding Y, Kuang Y, Yao Z, Xun Y, Li F, Li H, Hu J, Liu Z, Wang T, Hao Y, Jiao X, Guan W, Tao Z, Ren S, Chen K
Nature genetics 2024 Mar;56(3):442-457
Nature genetics 2024 Mar;56(3):442-457
MitoQ Alleviated PM(2.5) Induced Pulmonary Epithelial Cells Injury by Inhibiting Mitochondrial-Mediated Apoptosis.
Weng AB, Deng MM, Liu XD, Wang HB, Lin Q
Iranian journal of public health 2024 Mar;53(3):614-624
Iranian journal of public health 2024 Mar;53(3):614-624
Crocin Inhibits Orbital Fibroblasts Fibrosis in Thyroid-Associated Ophthalmopathy.
Xu S, Mao H
Current eye research 2024 Mar;49(3):330-337
Current eye research 2024 Mar;49(3):330-337
TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis.
Zhou ZX, Ma XF, Xiong WH, Ren Z, Jiang M, Deng NH, Zhou BB, Liu HT, Zhou K, Hu HJ, Tang HF, Zheng H, Jiang ZS
Atherosclerosis 2024 Mar;390:117430
Atherosclerosis 2024 Mar;390:117430
Knockdown of ARHGAP24 reduces intimal hyperplasia through inhibiting the proliferation and phenotypic switching of smooth muscle cells possibly by inactivating both AKT and ERK1/2 signaling pathways.
Liu W, Han J, Yang Q, Xia L, Chen C, Song J, Cai Y
Biochemistry and biophysics reports 2024 Mar;37:101591
Biochemistry and biophysics reports 2024 Mar;37:101591
Integrin β8 prevents pericyte-myofibroblast transition and renal fibrosis through inhibiting the TGF-β1/TGFBR1/Smad3 pathway in diabetic kidney disease.
Cao Y, Su H, Zeng J, Xie Y, Liu Z, Liu F, Qiu Y, Yi F, Lin J, Hammes HP, Zhang C
Translational research : the journal of laboratory and clinical medicine 2024 Mar;265:36-50
Translational research : the journal of laboratory and clinical medicine 2024 Mar;265:36-50
Arctium lappa L. polysaccharides enhanced the therapeutic effects of nasal ectomesenchymal stem cells against liver fibrosis by inhibiting the Wnt/β-catenin pathway.
Xiang W, Yin G, Liu H, Wei J, Yu X, Xie Y, Zhang L, XueTang, Jiang W, Lu N
International journal of biological macromolecules 2024 Mar;261(Pt 1):129670
International journal of biological macromolecules 2024 Mar;261(Pt 1):129670
Primary cilia are critical for tracheoesophageal septation.
Fitzsimons LA, Tasouri E, Willaredt MA, Stetson D, Gojak C, Kirsch J, Gardner HAR, Gorgas K, Tucker KL
Developmental dynamics : an official publication of the American Association of Anatomists 2024 Mar;253(3):312-332
Developmental dynamics : an official publication of the American Association of Anatomists 2024 Mar;253(3):312-332
Machine learning and single-cell transcriptome profiling reveal regulation of fibroblast activation through THBS2/TGFβ1/P-Smad2/3 signalling pathway in hypertrophic scar.
Song B, Zhu Y, Zhao Y, Wang K, Peng Y, Chen L, Yu Z, Song B
International wound journal 2024 Mar;21(3):e14481
International wound journal 2024 Mar;21(3):e14481
Natural intestinal metabolite xylitol reduces BRD4 levels to mitigate renal fibrosis.
Tan Z, Wang Z, Zeng Q, Liu X, Zhang Y, Li S, Huang J, Zeng Y, Huang Z, Jin C, Fu N, Zhao Q, Mu Y, Wang Z, Xiao J, Yang H, Ke G
Clinical and translational science 2024 Mar;17(3):e13770
Clinical and translational science 2024 Mar;17(3):e13770
Structure-based design and synthesis of anti-fibrotic compounds derived from para-positioned 3,4,5-trisubstituted benzene.
Hong W, Xiao T, Lin G, Liu C, Li H, Li Y, Hu H, Wu S, Wang S, Liang Z, Lin T, Liu J, Chen X
Bioorganic chemistry 2024 Mar;144:107113
Bioorganic chemistry 2024 Mar;144:107113
Bacterial Cellulose-Based Bandages with Integrated Antibacteria and Electrical Stimulation for Advanced Wound Management.
Liu X, Cai Z, Pei M, Zeng H, Yang L, Cao W, Zhou X, Chen F
Advanced healthcare materials 2024 Mar;13(7):e2302893
Advanced healthcare materials 2024 Mar;13(7):e2302893
LATS2 degradation promoted fibrosis damage and rescued by vitamin K3 in lupus nephritis.
Cheng C, Yang H, Yang C, Xie J, Wang J, Cheng L, He J, Li H, Yuan H, Guo F, Li M, Liu S
Arthritis research & therapy 2024 Mar 9;26(1):64
Arthritis research & therapy 2024 Mar 9;26(1):64
Network pharmacology and transcriptomic profiling elucidate the therapeutic effects of Ranunculus ternatus Thunb on liver fibrosis via MK3-NF-κB inhibition.
Han L, Lin G, Li J, Zhang Q, Ran T, Huang T, Hu R, Feng S, Zou G, Chen S, Zhao X
Aging 2024 Mar 8;16(5):4759-4777
Aging 2024 Mar 8;16(5):4759-4777
Macrophage-derived exosomal HMGB3 regulates silica-induced pulmonary inflammation by promoting M1 macrophage polarization and recruitment.
Qin X, Niu Z, Chen H, Hu Y
Particle and fibre toxicology 2024 Mar 7;21(1):12
Particle and fibre toxicology 2024 Mar 7;21(1):12
Spinosin inhibits activated hepatic stellate cell to attenuate liver fibrosis by targeting Nur77/ASK1/p38 MAPK signaling pathway.
Lin G, Li W, Hong W, Zhu D, Hu H, Fu J, Gao Y, Chen S, Chai D, Zeng JZ
European journal of pharmacology 2024 Mar 5;966:176270
European journal of pharmacology 2024 Mar 5;966:176270
Augmentation of scleral glycolysis promotes myopia through histone lactylation.
Lin X, Lei Y, Pan M, Hu C, Xie B, Wu W, Su J, Li Y, Tan Y, Wei X, Xue Z, Xu R, Di M, Deng H, Liu S, Yang X, Qu J, Chen W, Zhou X, Zhao F
Cell metabolism 2024 Mar 5;36(3):511-525.e7
Cell metabolism 2024 Mar 5;36(3):511-525.e7
Early-life ruminal microbiome-derived indole-3-carboxaldehyde and prostaglandin D2 are effective promoters of rumen development.
Sun D, Bian G, Zhang K, Liu N, Yin Y, Hou Y, Xie F, Zhu W, Mao S, Liu J
Genome biology 2024 Mar 4;25(1):64
Genome biology 2024 Mar 4;25(1):64
Tryptanthrin promotes pressure ulcers healing in mice by inhibiting macrophage-mediated inflammation via cGAS/STING pathways.
He Y, Yue J, Teng Y, Fan Z, Jia M, Teng H, Zhuge L
International immunopharmacology 2024 Mar 30;130:111687
International immunopharmacology 2024 Mar 30;130:111687
Curculigoside Attenuates Endoplasmic Reticulum Stress-Induced Epithelial Cell and Fibroblast Senescence by Regulating the SIRT1-P300 Signaling Pathway.
Xie W, Deng L, Qian R, Huang X, Liu W, Tang S
Antioxidants (Basel, Switzerland) 2024 Mar 29;13(4)
Antioxidants (Basel, Switzerland) 2024 Mar 29;13(4)
Increased extracellular matrix stiffness regulates myofibroblast transformation through induction of autophagy-mediated Kindlin-2 cytoplasmic translocation.
Zhao Z, Han W, Huang G, He Y, Zuo X, Hong L
Experimental cell research 2024 Mar 15;436(2):113974
Experimental cell research 2024 Mar 15;436(2):113974
The mechanisms and therapeutic potential of clopidogrel in mitigating diabetic cardiomyopathy in db/db mice.
Li B, Zhang Y, Zheng Y, Cai H
iScience 2024 Mar 15;27(3):109134
iScience 2024 Mar 15;27(3):109134
Cancer-associated fibroblast-secreted FGF7 as an ovarian cancer progression promoter.
Feng S, Ding B, Dai Z, Yin H, Ding Y, Liu S, Zhang K, Lin H, Xiao Z, Shen Y
Journal of translational medicine 2024 Mar 15;22(1):280
Journal of translational medicine 2024 Mar 15;22(1):280
Nitric oxide nano-reactor DNMF/PLGA enables tumor vascular microenvironment and chemo-hyperthermia synergetic therapy.
Wang R, Cheng L, He L, Du C, Wang H, Peng B, Yu X, Liu W, Luo W, Ran H, Yang L
Journal of nanobiotechnology 2024 Mar 13;22(1):110
Journal of nanobiotechnology 2024 Mar 13;22(1):110
Bicyclol alleviates obesity-induced renal injury by inhibiting JNK and NF-κB-mediated inflammation.
Zhang L, Wang J, Xu T, Luo Y, Cai Z, Jiang Y, Jin T, Bao H, Wang Y
International immunopharmacology 2024 Mar 10;129:111609
International immunopharmacology 2024 Mar 10;129:111609
Fibroblast-Specific Depletion of Human Antigen R Alleviates Myocardial Fibrosis Induced by Cardiac Stress.
Patil M, Singh S, Dubey PK, Tousif S, Umbarkar P, Zhang Q, Lal H, Sewell-Loftin MK, Umeshappa CS, Ghebre YT, Pogwizd S, Zhang J, Krishnamurthy P
JACC. Basic to translational science 2024 Jun;9(6):754-770
JACC. Basic to translational science 2024 Jun;9(6):754-770
Generation of a human induced pluripotent stem cell line harboring heteroplasmic m.3243A > G mutation in MT-TL1 gene.
Song M, Chen S, Zhang M, Hu S, Lei W, Yu M
Stem cell research 2024 Jun;77:103387
Stem cell research 2024 Jun;77:103387
Bioresponsive nanocomplex integrating cancer-associated fibroblast deactivation and immunogenic chemotherapy for rebuilding immune-excluded tumors.
Liu L, Zhang B, Wu X, Cheng G, Han X, Xin X, Qin C, Yang L, Huo M, Yin L
Nanomedicine : nanotechnology, biology, and medicine 2024 Jun;58:102743
Nanomedicine : nanotechnology, biology, and medicine 2024 Jun;58:102743
A 3D spheroid model of quadruple cell co-culture with improved liver functions for hepatotoxicity prediction.
Sun B, Liang Z, Wang Y, Yu Y, Zhou X, Geng X, Li B
Toxicology 2024 Jun;505:153829
Toxicology 2024 Jun;505:153829
Stiffened tumor microenvironment enhances perineural invasion in breast cancer via integrin signaling.
Han B, Guan X, Ma M, Liang B, Ren L, Liu Y, Du Y, Jiang SH, Song D
Cellular oncology (Dordrecht, Netherlands) 2024 Jun;47(3):867-882
Cellular oncology (Dordrecht, Netherlands) 2024 Jun;47(3):867-882
TRPC6 Knockout Alleviates Renal Fibrosis through PI3K/AKT/GSK3B Pathway.
Sun AB, Li FH, Zhu L, Zeng XX, Zhu M, Lei QH, Liao YH
Current medical science 2024 Jun;44(3):589-602
Current medical science 2024 Jun;44(3):589-602
Cancer associated fibroblast secreted miR-432-5p targets CHAC1 to inhibit ferroptosis and promote acquired chemoresistance in prostate cancer.
Zhao J, Shen J, Mao L, Yang T, Liu J, Hongbin S
Oncogene 2024 Jun;43(27):2104-2114
Oncogene 2024 Jun;43(27):2104-2114
Dihydromyricetin alleviates inflammatory bowel disease associated intestinal fibrosis by inducing autophagy through the PI3K/AKT/mTOR signaling pathway.
Wang X, Li X, Ma X, Zhang L, Han T, Zhang D
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jun;397(6):4183-4194
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jun;397(6):4183-4194
Eosinophil peroxidase promotes bronchial epithelial cells to secrete asthma-related factors and induces the early stage of airway remodeling.
Xu L, Huang X, Chen Z, Yang M, Deng J
Clinical immunology (Orlando, Fla.) 2024 Jun;263:110228
Clinical immunology (Orlando, Fla.) 2024 Jun;263:110228
CILP2 promotes hypertrophic scar through Snail acetylation by interaction with ACLY.
Wang J, Du J, Wang Y, Song Y, Wu J, Wang T, Yu Z, Song B
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167202
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167202
Bile acids induce liver fibrosis through the NLRP3 inflammasome pathway and the mechanism of FXR inhibition of NLRP3 activation.
Feng S, Xie X, Li J, Xu X, Chen C, Zou G, Lin G, Huang T, Hu R, Ran T, Han L, Zhang Q, Li Y, Zhao X
Hepatology international 2024 Jun;18(3):1040-1052
Hepatology international 2024 Jun;18(3):1040-1052
Hsa_circ_0004214 involved in the epithelial-mesenchymal transition induced by beryllium sulfate through modulating JAK-STAT signaling pathway.
Jin H, Liu Y, Lei Y, Li G, Huang L, Zhang Z
Toxicology research 2024 Jun;13(3):tfae067
Toxicology research 2024 Jun;13(3):tfae067
microRNA-125b-1-3p mediates autophagy via the RRAGD/mTOR/ULK1 signaling pathway and mitigates atherosclerosis progression.
Chen X, Cao Y, Guo Y, Liu J, Ye X, Li H, Zhang L, Feng W, Xian S, Yang Z, Wang L, Wang T
Cellular signalling 2024 Jun;118:111136
Cellular signalling 2024 Jun;118:111136
Fraxinellone alleviates colitis-related intestinal fibrosis by blocking the circuit between PD-1(+) Th17 cells and fibroblasts.
Xu Y, Zheng C, Jiang P, Ji S, Ullah S, Zhao Y, Su D, Xu G, Zhang M, Zou X
International immunopharmacology 2024 Jun 30;135:112298
International immunopharmacology 2024 Jun 30;135:112298
Extracellular vesicles activated cancer-associated fibroblasts promote lung cancer metastasis through mitophagy and mtDNA transfer.
Zhou Z, Qu C, Zhou P, Zhou Q, Li D, Wu X, Yang L
Journal of experimental & clinical cancer research : CR 2024 Jun 3;43(1):158
Journal of experimental & clinical cancer research : CR 2024 Jun 3;43(1):158
Deciphering the molecular nexus of BTG2 in periodontitis and diabetic kidney disease.
Pan B, Teng Y, Wang R, Chen D, Chen H
BMC medical genomics 2024 Jun 3;17(1):152
BMC medical genomics 2024 Jun 3;17(1):152
Bioactive compound schaftoside from Clinacanthus nutans attenuates acute liver injury by inhibiting ferroptosis through activation the Nrf2/GPX4 pathway.
Yu Y, Liang J, Yuan Z, Wang A, Liu X, Chen Y, Zhang M, Gao Y, Zhang H, Liu Y
Journal of ethnopharmacology 2024 Jun 28;328:118135
Journal of ethnopharmacology 2024 Jun 28;328:118135
Multiomic analysis of monocyte-derived alveolar macrophages in idiopathic pulmonary fibrosis.
Zhang M, Zhang J, Hu H, Zhou Y, Lin Z, Jing H, Sun B
Journal of translational medicine 2024 Jun 27;22(1):598
Journal of translational medicine 2024 Jun 27;22(1):598
PGC1-Alpha/Sirt3 Signaling Pathway Mediates the Anti-Pulmonary Fibrosis Effect of Hirudin by Inhibiting Fibroblast Senescence.
He B, Zeng Q, Tian Y, Luo Y, Liao M, Huang W, Wu B, Luo Z, Huang X, Liu W, Tang S
Biomedicines 2024 Jun 27;12(7)
Biomedicines 2024 Jun 27;12(7)
Mesenchymal stem cells-extracellular vesicles alleviate pulmonary fibrosis by regulating immunomodulators.
Gao Y, Liu MF, Li Y, Liu X, Cao YJ, Long QF, Yu J, Li JY
World journal of stem cells 2024 Jun 26;16(6):670-689
World journal of stem cells 2024 Jun 26;16(6):670-689
Single-cell transcriptome profiling highlights the importance of telocyte, kallikrein genes, and alternative splicing in mouse testes aging.
Guo W, Zhang Z, Kang J, Gao Y, Qian P, Xie G
Scientific reports 2024 Jun 26;14(1):14795
Scientific reports 2024 Jun 26;14(1):14795
Improved Cell Adhesion on Self-Assembled Chiral Nematic Cellulose Nanocrystal Films.
Wang X, Xu H, Ning F, Duan S, Hu Y, Ding X, Xu FJ
Macromolecular rapid communications 2024 Jun 24;:e2400339
Macromolecular rapid communications 2024 Jun 24;:e2400339
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis.
Xie C, Zhong L, Feng H, Wang R, Shi Y, Lv Y, Hu Y, Li J, Xiao D, Liu S, Chen Q, Tao Y
International journal of oral science 2024 Jun 20;16(1):48
International journal of oral science 2024 Jun 20;16(1):48
Nrf2 mediates the effects of shionone on silica-induced pulmonary fibrosis.
Wang G, Xie W, Deng L, Huang X, Sun M, Liu W, Tang S
Chinese medicine 2024 Jun 19;19(1):88
Chinese medicine 2024 Jun 19;19(1):88
Graphene Far-Infrared Irradiation Can Effectively Relieve the Blood Pressure Level of Rat Untr-HT in Primary Hypertension.
Lu G, Guo H, Zhang Y, Zhang M, Zhang T, Hu G, Zhang Q
International journal of molecular sciences 2024 Jun 18;25(12)
International journal of molecular sciences 2024 Jun 18;25(12)
Processing of angiocrine alarmin IL-1α in endothelial cells promotes lung and liver fibrosis.
Zhang C, Ma J, Zhang X, Zhou D, Cao Z, Qiao L, Chen G, Yang L, Ding BS
International immunopharmacology 2024 Jun 15;134:112176
International immunopharmacology 2024 Jun 15;134:112176
EHHADH deficiency regulates pexophagy and accelerates tubulointerstitial injury in diabetic kidney disease.
Kan S, Hou Q, Shi J, Zhang M, Xu F, Liu Z, Jiang S
Cell death discovery 2024 Jun 15;10(1):289
Cell death discovery 2024 Jun 15;10(1):289
Xinbao Pill ameliorates heart failure via regulating the SGLT1/AMPK/PPARα axis to improve myocardial fatty acid energy metabolism.
Pan L, Xu Z, Wen M, Li M, Lyu D, Xiao H, Li Z, Xiao J, Cheng Y, Huang H
Chinese medicine 2024 Jun 11;19(1):82
Chinese medicine 2024 Jun 11;19(1):82
Alantolactone attenuates high-fat diet-induced inflammation and oxidative stress in non-alcoholic fatty liver disease.
Wang J, Jiang Y, Jin L, Qian C, Zuo W, Lin J, Xie L, Jin B, Zhao Y, Huang L, Wang Y
Nutrition & diabetes 2024 Jun 10;14(1):41
Nutrition & diabetes 2024 Jun 10;14(1):41
Amelioration of NAFLD by sleeve gastrectomy-triggered hepatocyte regeneration in mice - experimental research.
Yu T, Ma X, Cheng Y, Wang Z, Zhang G, Ding H, Yin J, Wang Y, Hu S
International journal of surgery (London, England) 2024 Jun 1;110(6):3307-3325
International journal of surgery (London, England) 2024 Jun 1;110(6):3307-3325
Carnosol prevents cardiac remodeling and ventricular arrhythmias in pressure overload-induced heart failure mice.
Fang Z, Lu M, Huang R, Wang G, Yushanjiang F, Jiang X, Li J
Phytotherapy research : PTR 2024 Jul;38(7):3763-3781
Phytotherapy research : PTR 2024 Jul;38(7):3763-3781
Silibinin attenuates TGF-β2-induced fibrogenic changes in human trabecular meshwork cells by targeting JAK2/STAT3 and PI3K/AKT signaling pathways.
Wu X, Liang J, Liu J, Huang Y, Zhang L, Liu X, Guo J, Zhang M, Chen Y, Wang J
Experimental eye research 2024 Jul;244:109939
Experimental eye research 2024 Jul;244:109939
Resistance exercise upregulates Irisin expression and suppresses myocardial fibrosis following myocardial infarction via activating AMPK-Sirt1 and inactivating TGFβ1-Smad2/3.
Li H, Qin S, Tang J, Wang T, Ren W, Di L, Bo W, Ma Y, Wu F, Xu Z, Song W, Cai M, Xi Y, Tian Z
Acta physiologica (Oxford, England) 2024 Jul;240(7):e14163
Acta physiologica (Oxford, England) 2024 Jul;240(7):e14163
The dual role of 20(S)-protopanaxadiol in alleviating pulmonary fibrosis through the gut-lung axis.
Ruan Y, Ren G, Wang M, Lv W, Shimizu K, Zhang C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155699
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155699
Repair potential of self-assembling peptide hydrogel in a mouse model of anterior cruciate ligament reconstruction.
Fujino K, Yamamoto N, Yoshimura Y, Yokota A, Hirano Y, Neo M
Journal of experimental orthopaedics 2024 Jul;11(3):e12061
Journal of experimental orthopaedics 2024 Jul;11(3):e12061
Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos.
Zhou B, Feng C, Sun S, Chen X, Zhuansun D, Wang D, Yu X, Meng X, Xiao J, Wu L, Wang J, Wang J, Chen K, Li Z, You J, Mao H, Yang S, Zhang J, Jiao C, Li Z, Yu D, Wu X, Zhu T, Yang J, Xiang L, Liu J, Chai T, Shen J, Mao CX, Hu J, Hao X, Xiong B, Zheng S, Liu Z, Feng J
Developmental cell 2024 Jul 8;59(13):1689-1706.e8
Developmental cell 2024 Jul 8;59(13):1689-1706.e8
Arctigenin induces activated HSCs quiescence via AMPK-PPARγ pathway to ameliorate liver fibrosis in mice.
Lv M, Chen S, Shan M, Si Y, Huang C, Chen J, Gong L
European journal of pharmacology 2024 Jul 5;974:176629
European journal of pharmacology 2024 Jul 5;974:176629
Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps.
Lai Y, Yang N, Shi D, Ma X, Huang Y, Lu J, Zhang X, Zhou H, Gao W, Mao C, Wang L
European journal of pharmacology 2024 Jul 5;974:176621
European journal of pharmacology 2024 Jul 5;974:176621
Sestrin2 Restricts Endothelial-to-Mesenchymal Transition Induced by Lipolysaccharide via Autophagy.
Huang R, Liu L, Shen K, Duan C, Fan Z
Journal of integrative neuroscience 2024 Jul 5;23(7):124
Journal of integrative neuroscience 2024 Jul 5;23(7):124
The miR-15b-5p/miR-379-3p-FOXO axis regulates cell cycle and apoptosis in scleral remodeling during experimental myopia.
Zhang R, Wen Y, Liu J, Hao J, Peng Y, Zhang M, Xie Y, Yang Z, Yin X, Shi Y, Bi H, Guo D
Journal of translational medicine 2024 Jul 30;22(1):710
Journal of translational medicine 2024 Jul 30;22(1):710
Inhibition of N-acetylglucosaminyltransferase V alleviates diabetic cardiomyopathy in mice by attenuating cardiac hypertrophy and fibrosis.
Zhao R, Hu J, Wen H, Zhao J, Wang Y, Niu X, Zhang M, Wang T, Li Y
Nutrition & metabolism 2024 Jul 30;21(1):53
Nutrition & metabolism 2024 Jul 30;21(1):53
DKK1 loss promotes endometrial fibrosis via autophagy and exosome-mediated macrophage-to-myofibroblast transition.
Zhang Z, Hu J
Journal of translational medicine 2024 Jul 3;22(1):617
Journal of translational medicine 2024 Jul 3;22(1):617
Fabrication of heterocellular spheroids with controllable core-shell structure using inertial focusing effect for scaffold-free 3D cell culture models.
Tang T, Zhang P, Zhang Q, Man X, Xu Y
Biofabrication 2024 Jul 25;16(4)
Biofabrication 2024 Jul 25;16(4)
Zhen-wu-tang protects against myocardial fibrosis by inhibiting M1 macrophage polarization via the TLR4/NF-κB pathway.
Fang R, Zhou R, Ju D, Li M, Wang H, Pan L, Wang X, Han M, Yu Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155719
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155719
Endothelial progenitor cells control remodeling of uterine spiral arteries for the establishment of utero-placental circulation.
Tan B, Lin L, Yuan Y, Long Y, Kang Y, Huang B, Huang LF, Li JH, Tong C, Qi HB
Developmental cell 2024 Jul 22;59(14):1842-1859.e12
Developmental cell 2024 Jul 22;59(14):1842-1859.e12
CXCL3/TGF-β-mediated crosstalk between CAFs and tumor cells augments RCC progression and sunitinib resistance.
Wang Y, Ding W, Hao W, Gong L, Peng Y, Zhang J, Qian Z, Xu K, Cai W, Gao Y
iScience 2024 Jul 19;27(7):110224
iScience 2024 Jul 19;27(7):110224
Polystyrene nanoplastics exposure causes erectile dysfunction in rats.
Wang M, Dai B, Liu Q, Wang X, Xiao Y, Zhang G, Jiang H, Zhang X, Zhang L
Ecotoxicology and environmental safety 2024 Jul 15;280:116551
Ecotoxicology and environmental safety 2024 Jul 15;280:116551
Isorhamnetin inhibits hypertrophic scar formation through TGF-β1/Smad and TGF-β1/CREB3L1 signaling pathways.
Wu J, Song Y, Wang J, Wang T, Yang L, Shi Y, Song B, Yu Z
Heliyon 2024 Jul 15;10(13):e33802
Heliyon 2024 Jul 15;10(13):e33802
The ANGPTL4-HIF-1α loop: a critical regulator of renal interstitial fibrosis.
Li Y, Chen S, Yang Q, Liu X, Zhou W, Kang T, Wu W, Ou S
Journal of translational medicine 2024 Jul 11;22(1):649
Journal of translational medicine 2024 Jul 11;22(1):649
PEX3 promotes regenerative repair after myocardial injury in mice through facilitating plasma membrane localization of ITGB3.
Sun JT, Wang ZM, Zhou LH, Yang TT, Zhao D, Bao YL, Wang SB, Gu LF, Chen JW, Shan TK, Wei TW, Wang H, Wang QM, Kong XQ, Xie LP, Gu AH, Zhao Y, Chen F, Ji Y, Cui YQ, Wang LS
Communications biology 2024 Jul 1;7(1):795
Communications biology 2024 Jul 1;7(1):795
Targeting of G protein-coupled receptor 39 alleviates angiotensin II-induced renal damage by reducing ribonucleotide reductase M2.
Hua D, Huang W, Xu W, Zhang Y, Xie Q, Li P, Sheng Y
Experimental cell research 2024 Jul 1;440(1):114102
Experimental cell research 2024 Jul 1;440(1):114102
Loss of STARD13 contributes to aggressive phenotype transformation and poor prognosis in papillary thyroid carcinoma.
Zeng C, Li H, Liang W, Chen J, Zhang Y, Zhang H, Xiao H, Li Y, Guan H
Endocrine 2024 Jan;83(1):127-141
Endocrine 2024 Jan;83(1):127-141
YTHDC1 delays cellular senescence and pulmonary fibrosis by activating ATR in an m6A-independent manner.
Zhang C, Chen L, Xie C, Wang F, Wang J, Zhou H, Liu Q, Zeng Z, Li N, Huang J, Zhao Y, Liu H
The EMBO journal 2024 Jan;43(1):61-86
The EMBO journal 2024 Jan;43(1):61-86
Uric acid promotes interleukin-17 expression to cause kidney injury.
Yang L, He T, Yu Y
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23550
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23550
A responsive hydrogel modulates innate immune cascade fibrosis to promote ocular surface reconstruction after chemical injury.
Zhang J, Su L, Liu Z, Tang J, Zhang L, Li Z, Zhou D, Sun Z, Xi K, Lu P, Deng G
Journal of controlled release : official journal of the Controlled Release Society 2024 Jan;365:1124-1138
Journal of controlled release : official journal of the Controlled Release Society 2024 Jan;365:1124-1138
Chitosan-based oral nanoparticles as an efficient platform for kidney-targeted drug delivery in the treatment of renal fibrosis.
Zhang Q, Li Y, Wang S, Gu D, Zhang C, Xu S, Fang X, Li C, Wu H, Xiong W
International journal of biological macromolecules 2024 Jan;256(Pt 1):128315
International journal of biological macromolecules 2024 Jan;256(Pt 1):128315
A hyaluronic acid / chitosan composite functionalized hydrogel based on enzyme-catalyzed and Schiff base reaction for promoting wound healing.
Li J, Su J, Liang J, Zhang K, Xie M, Cai B, Li J
International journal of biological macromolecules 2024 Jan;255:128284
International journal of biological macromolecules 2024 Jan;255:128284
AT1R autoantibody promotes phenotypic transition of smooth muscle cells by activating AT1R-OAS2.
Zhang X, Li B, Yan Y, Sun F, Zhang S, Wang M, Liu H
Biochemical pharmacology 2024 Jan;219:115977
Biochemical pharmacology 2024 Jan;219:115977
Overexpression of Corin Ameliorates Kidney Fibrosis through Inhibition of Wnt/β-Catenin Signaling in Mice.
Su X, Li S, Zhang Y, Tie X, Feng R, Guo X, Qiao X, Wang L
The American journal of pathology 2024 Jan;194(1):101-120
The American journal of pathology 2024 Jan;194(1):101-120
Melatonin inhibits fibroblast cell functions and hypertrophic scar formation by enhancing autophagy through the MT2 receptor-inhibited PI3K/Akt /mTOR signaling.
Dong Y, Cao X, Huang J, Hu Z, Chen C, Chen M, Long Q, Xu Z, Lv D, Rong Y, Luo S, Wang H, Deng W, Tang B
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166887
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166887
Inhibition of TGFβ1 activation prevents radiation-induced lung fibrosis.
Yi M, Yuan Y, Ma L, Li L, Qin W, Wu B, Zheng B, Liao X, Hu G, Liu B
Clinical and translational medicine 2024 Jan;14(1):e1546
Clinical and translational medicine 2024 Jan;14(1):e1546
Quantitative Analysis of the Concentration of Trifluridine in Tumor Hypoxic Regions Using a Novel Platform Combining Functional Endoscopy and Mass Spectrometry.
Koganemaru S, Fuchigami H, Yamashita H, Morizono C, Sunakawa H, Kawazoe A, Nakamura Y, Kuboki Y, Shitara K, Yano T, Doi T, Yasunaga M
Clinical pharmacology and therapeutics 2024 Jan;115(1):62-70
Clinical pharmacology and therapeutics 2024 Jan;115(1):62-70
Metabolomics reveals that chronic restraint stress alleviates carbon tetrachloride-induced hepatic fibrosis through the INSR/PI3K/AKT/AMPK pathway.
Zhang S, Liu B, Huang L, Zhang R, An L, Liu Z
Journal of molecular medicine (Berlin, Germany) 2024 Jan;102(1):113-128
Journal of molecular medicine (Berlin, Germany) 2024 Jan;102(1):113-128
Diosmin ameliorates renal fibrosis through inhibition of inflammation by regulating SIRT3-mediated NF-κB p65 nuclear translocation.
Zhao WM, Li XL, Zhu Y, Shi R, Wang ZJ, Xiao JP, Wang DG
BMC complementary medicine and therapies 2024 Jan 9;24(1):29
BMC complementary medicine and therapies 2024 Jan 9;24(1):29
Combination of mangiferin and T0901317 targeting autophagy promotes cholesterol efflux from macrophage foam cell in atherosclerosis.
Chen Q, Wang S, Bao R, Wang D, Wu Y, Zhang Y, Liu M, Wang T
Chinese medicine 2024 Jan 5;19(1):5
Chinese medicine 2024 Jan 5;19(1):5
Menstrual blood-derived stem cells exosomal miR-let-7 to ameliorate pulmonary fibrosis through inhibiting ferroptosis by Sp3/HDAC2/Nrf2 signaling pathway.
Sun L, He X, Kong J, Yu H, Wang Y
International immunopharmacology 2024 Jan 5;126:111316
International immunopharmacology 2024 Jan 5;126:111316
Lactate accumulation induced by Akt2-PDK1 signaling promotes pulmonary fibrosis.
Sun Z, Ji Z, He W, Duan R, Qu J, Yu G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23426
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23426
MicroRNA miR-181d-5p regulates the MAPK signaling pathway by targeting mitogen-activated protein kinase 8 (MAPK8) to improve lupus nephritis.
Chai F, Peng H, Qin L, Liu C, Zeng Y, Wang R, Xu G, Wang R, Wei G, Huang H, Lan Y, Chen W, Wang C
Gene 2024 Jan 30;893:147961
Gene 2024 Jan 30;893:147961
The anti-liver fibrosis effect of Tibetan medicine (Qiwei Tiexie capsule) is related to the inhibition of NLRP3 inflammasome activation in vivo and in vitro.
Wang S, Ye F, Ren Q, Sun S, Xia W, Wang Z, Guo H, Li H, Zhang S, Lowe S, Chen M, Du Q, Weihong Li
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117283
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117283
Phthalides from the rhizome of Ligusticum chuanxiong Hort. attenuate diabetic nephropathy in mice.
Qi XY, Peng GC, Han QT, Yan J, Chen LZ, Wang T, Xu LT, Liu MJ, Xu ZP, Wang XN, Shen T
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117247
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117247
Quercetin inhibits mesothelial-mesenchymal transition and alleviates postoperative peritoneal adhesions by blocking the TGF-β1/PI3K/AKT pathway.
Li G, Ren Y, Li E, Deng K, Qu C, Zhang J, Zhang L, Wang X, Lian J, Zhou H, Wang Z, Shen T, Li X, Jiang Z
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117242
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117242
S100A8/A9 promotes endometrial fibrosis via regulating RAGE/JAK2/STAT3 signaling pathway.
Xin X, Liu H, Zhang S, Li P, Zhao X, Zhang X, Li S, Wu S, Zhao F, Tan J
Communications biology 2024 Jan 22;7(1):116
Communications biology 2024 Jan 22;7(1):116
Cancer-associated fibroblast-derived extracellular vesicles promote lymph node metastases in oral cavity squamous cell carcinoma by encapsulating ITGB1 and BMI1.
Lv T, Liu H, Mao L, Song Y, Liao L, Zhong K, Shuai B, Luo Y, Guo T, Huang W, Zhang S
BMC cancer 2024 Jan 22;24(1):113
BMC cancer 2024 Jan 22;24(1):113
Self-assembled coating with a metal-polyphenolic network for intraocular lens modification to prevent posterior capsule opacification.
Wang Y, Wen C, Jing R, Yang Y, Qin Y, Qi T, Hu C, Bai X, Wu C, Pei C
Biomedical materials (Bristol, England) 2024 Jan 22;19(2)
Biomedical materials (Bristol, England) 2024 Jan 22;19(2)
The SIRT1/Nrf2 signaling pathway mediates the anti-pulmonary fibrosis effect of liquiritigenin.
Hua Q, Ren L
Chinese medicine 2024 Jan 18;19(1):12
Chinese medicine 2024 Jan 18;19(1):12
Phomopsterone B Alleviates Liver Fibrosis through mTOR-Mediated Autophagy and Apoptosis Pathway.
Peng ML, Zhang LJ, Luo Y, Xu SY, Long XM, Ao JL, Liao SG, Zhu QF, He X, Xu GB
Molecules (Basel, Switzerland) 2024 Jan 15;29(2)
Molecules (Basel, Switzerland) 2024 Jan 15;29(2)
Rehmannia glutinosa Libosch and Cornus officinalis Sieb herb couple ameliorates renal interstitial fibrosis in CKD rats by inhibiting the TGF-β1/MAPK signaling pathway.
Zhu JH, Wang L, Ma ZX, Duan JA, Tao JH
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117039
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117039
Network pharmacology, molecular docking and experimental verification of the mechanism of huangqi-jixuecao herb pair in treatment of peritoneal fibrosis.
Dai H, Shan Y, Yu M, Wang F, Zhou Z, Sun J, Sheng L, Huang L, Sheng M
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116874
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116874
PRMT3 methylates HIF-1α to enhance the vascular calcification induced by chronic kidney disease.
Zhou G, Zhang C, Peng H, Su X, Huang Q, Zhao Z, Zhao G
Molecular medicine (Cambridge, Mass.) 2024 Jan 10;30(1):8
Molecular medicine (Cambridge, Mass.) 2024 Jan 10;30(1):8
Claudin-18.2 mediated interaction of gastric Cancer cells and Cancer-associated fibroblasts drives tumor progression.
Liu S, Zhang Z, Jiang L, Zhang M, Zhang C, Shen L
Cell communication and signaling : CCS 2024 Jan 10;22(1):27
Cell communication and signaling : CCS 2024 Jan 10;22(1):27
Hydrogen sulfide attenuates atherosclerosis induced by low shear stress by sulfhydrylating endothelium NFIL3 to restrain MEST mediated endothelial mesenchymal transformation.
Zhou K, Luo W, Gui DD, Ren Z, Wei DH, Liu LS, Li GH, Tang ZH, Xiong WH, Hu HJ, Jiang ZS
Nitric oxide : biology and chemistry 2024 Jan 1;142:47-57
Nitric oxide : biology and chemistry 2024 Jan 1;142:47-57
Oncostatin M/Oncostatin M Receptor Signal Induces Radiation-Induced Heart Fibrosis by Regulating SMAD4 in Fibroblast.
Xu P, Yi Y, Xiong L, Luo Y, Xie C, Luo D, Zeng Z, Liu A
International journal of radiation oncology, biology, physics 2024 Jan 1;118(1):203-217
International journal of radiation oncology, biology, physics 2024 Jan 1;118(1):203-217
Establishment of an immortalized cell line derived from human adenomyosis ectopic lesions.
Wang Z, Cui F, Chen Y, Liu H, Zhang Y, Shi Y, Zhang Y, Wang Y, Liang N, Xu L, Liu Y, Liu Z, Shi W
Tissue & cell 2024 Feb;86:102284
Tissue & cell 2024 Feb;86:102284
Costunolide attenuates high-fat diet-induced inflammation and oxidative stress in non-alcoholic fatty liver disease.
Wang J, Jin B, Chen Y, Chen Y, Zuo W, Huang L, Lin J, Jiang Y, Xie L, Lian X, Wang Y
Drug development research 2024 Feb;85(1):e22150
Drug development research 2024 Feb;85(1):e22150
IRF4 Participates in Pulmonary Fibrosis Induced by Silica Particles through Regulating Macrophage Polarization and Fibroblast Activation.
Jiao B, Zhang Q, Jin C, Yu H, Wu Q
Inflammation 2024 Feb;47(1):45-59
Inflammation 2024 Feb;47(1):45-59
hPMSCs Regulate the Level of TNF-α and IL-10 in Th1 Cells and Improve Hepatic Injury in a GVHD Mouse Model via CD73/ADO/Fyn/Nrf2 Axis.
Zhang H, Han K, Li H, Zhang J, Zhao Y, Wu Y, Wang B, Ma J, Luan X
Inflammation 2024 Feb;47(1):244-263
Inflammation 2024 Feb;47(1):244-263
Microplastics cause hepatotoxicity in diabetic mice by disrupting glucolipid metabolism via PP2A/AMPK/HNF4A and promoting fibrosis via the Wnt/β-catenin pathway.
Li X, Feng L, Kuang Q, Wang X, Yang J, Niu X, Gao L, Huang L, Luo P, Li L
Environmental toxicology 2024 Feb;39(2):1018-1030
Environmental toxicology 2024 Feb;39(2):1018-1030
An Injectable Composite Hydrogel of Verteporfin-Bonded Carboxymethyl Chitosan and Oxidized Sodium Alginate Facilitates Scarless Full-Thickness Skin Regeneration.
Yang JT, Wu D, Li J, Zhao C, Zhu L, Xu C, Xu N
Macromolecular bioscience 2024 Feb;24(2):e2300165
Macromolecular bioscience 2024 Feb;24(2):e2300165
The transformation of multifunctional bio-patch to hydrogel on skin wounds for efficient scarless wound healing.
Ying X, Yu C, Yang W, Ye L, Sun R, Gu T, Fan S, Yao S
Materials today. Bio 2024 Feb;24:100901
Materials today. Bio 2024 Feb;24:100901
Transcription factor c-Maf drives macrophages to promote hypertrophic scar formation.
Yang L, Song Y, Wang T, Cui Z, Wu J, Shi Y, Yu Z, Song B
Journal of cosmetic dermatology 2024 Feb;23(2):639-647
Journal of cosmetic dermatology 2024 Feb;23(2):639-647
BRG1 enhances porcine iPSC pluripotency through WNT/β-catenin and autophagy pathways.
Ren X, Xu J, Xue Q, Tong Y, Xu T, Wang J, Yang T, Chen Y, Shi D, Li X
Theriogenology 2024 Feb;215:10-23
Theriogenology 2024 Feb;215:10-23
Alleviative Effect of Lactoferrin Interventions Against the Hepatotoxicity Induced by Titanium Dioxide Nanoparticles.
Zhang W, Sun J, Liu F, Li S, Wang X, Su L, Liu G
Biological trace element research 2024 Feb;202(2):624-642
Biological trace element research 2024 Feb;202(2):624-642
Downregulation of TET2 Contributes to Nasal Polypogenesis Through Hypoxia-Inducible Factor 1α-Mediated Epithelial-to-Mesenchymal Transition.
Liu K, Xu Y
Clinical and experimental otorhinolaryngology 2024 Feb;17(1):64-77
Clinical and experimental otorhinolaryngology 2024 Feb;17(1):64-77
Identification of (E)-1-((1H-indol-3-yl)methylene)-4-substitute-thiosemicarbazones as potential anti-hepatic fibrosis agents.
Lin G, Zhong Y, Hu S, He F, Zhang Z, Li W, Hu H, Zeng JZ
Bioorganic chemistry 2024 Feb;143:107022
Bioorganic chemistry 2024 Feb;143:107022
Discovery of PRDM16-Mediated TRPA1 Induction as the Mechanism for Low Tubulo-Interstitial Fibrosis in Diabetic Kidney Disease.
Xu F, Jiang H, Li X, Pan J, Li H, Wang L, Zhang P, Chen J, Qiu S, Xie Y, Li Y, Zhang D, Dong Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2306704
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2306704
Wearable bioadhesive ultrasound shear wave elastography.
Liu HC, Zeng Y, Gong C, Chen X, Kijanka P, Zhang J, Genyk Y, Tchelepi H, Wang C, Zhou Q, Zhao X
Science advances 2024 Feb 9;10(6):eadk8426
Science advances 2024 Feb 9;10(6):eadk8426
The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3.
Wang Y, Li X, Guan X, Song Z, Liu H, Guan Z, Wang J, Zhu L, Zhang D, Zhao L, Xie P, Wei X, Shang N, Liu Y, Jin Z, Ji Z, Dai G
International journal of molecular sciences 2024 Feb 27;25(5)
International journal of molecular sciences 2024 Feb 27;25(5)
Endothelial Robo4 suppresses endothelial-to-mesenchymal transition induced by irradiation and improves hematopoietic reconstitution.
Adzraku SY, Cao C, Zhou Q, Yuan K, Hao X, Li Y, Yuan S, Huang Y, Xu K, Qiao J, Ju W, Zeng L
Cell death & disease 2024 Feb 21;15(2):159
Cell death & disease 2024 Feb 21;15(2):159
Galectin-3 is involved in inflammation and fibrosis in arteriogenic erectile dysfunction via the TLR4/MyD88/NF-κB pathway.
Wang G, Li R, Feng C, Li K, Liu S, Fu Q
Cell death discovery 2024 Feb 20;10(1):92
Cell death discovery 2024 Feb 20;10(1):92
Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence.
Sun DY, Wu WB, Wu JJ, Shi Y, Xu JJ, Ouyang SX, Chi C, Shi Y, Ji QX, Miao JH, Fu JT, Tong J, Zhang PP, Zhang JB, Li ZY, Qu LF, Shen FM, Li DJ, Wang P
Nature communications 2024 Feb 16;15(1):1429
Nature communications 2024 Feb 16;15(1):1429
Prostacyclin Mitigates Renal Fibrosis by Activating Fibroblast Prostaglandin I 2 Receptor.
Li J, Guan Y, Xu Y, Cao Y, Xie Q, Harris RC, Breyer MD, Lu L, Hao CM
Journal of the American Society of Nephrology : JASN 2024 Feb 1;35(2):149-165
Journal of the American Society of Nephrology : JASN 2024 Feb 1;35(2):149-165
C1q/tumor necrosis factor-related protein-6 suppresses the angiotensin II-induced differentiation of cardiac fibroblasts to myofibroblasts via activation of the AMPK pathway.
Wu D, Li S, Chen M, Zhang S, Wang Q
Tissue & cell 2024 Dec;91:102627
Tissue & cell 2024 Dec;91:102627
Up-regulation of long non-coding RNA H19 ameliorates renal tubulointerstitial fibrosis by reducing lipid deposition and inflammatory response through regulation of the microRNA-130a-3p/long-chain acyl-CoA synthetase 1 axis.
Jiang Y, Ma F, Wang J, Chen X, Xue L, Chen X, Hu J
Non-coding RNA research 2024 Dec;9(4):1120-1132
Non-coding RNA research 2024 Dec;9(4):1120-1132
Bleomycin induces endothelial cell pyroptosis and regulates fibrosis by activating the NLRP3/caspase-1/GSDMD pathway: a possible mechanism contributing to the sclerotherapy of venous malformations.
Chen S, Wang Y, Gao Q, Cui J, Shen W
Journal of molecular histology 2024 Dec;55(6):1239-1250
Journal of molecular histology 2024 Dec;55(6):1239-1250
[(18)F]AlF-CBP imaging of type I collagen for non-invasive monitoring of pulmonary fibrosis in preclinical models.
Liu Y, Tang P, Peng S, Zhong J, Xu Z, Zhong J, Su J, Zhong Y, Hu K
European journal of nuclear medicine and molecular imaging 2024 Dec;52(1):22-35
European journal of nuclear medicine and molecular imaging 2024 Dec;52(1):22-35
Chronic exposure to polystyrene microplastics induces renal fibrosis via ferroptosis.
Hong R, Shi Y, Fan Z, Gao Y, Chen H, Pan C
Toxicology 2024 Dec;509:153996
Toxicology 2024 Dec;509:153996
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease.
Du Y, Wu M, Song S, Bian Y, Shi Y
Renal failure 2024 Dec;46(1):2338933
Renal failure 2024 Dec;46(1):2338933
Krüppel-like factor 4 modulates the miR-101/COL10A1 axis to inhibit renal fibrosis after AKI by regulating epithelial-mesenchymal transition.
Zhao J, Wang X, Wu Y, Zhao C
Renal failure 2024 Dec;46(1):2316259
Renal failure 2024 Dec;46(1):2316259
Aristolochic acid I promotes renal tubulointerstitial fibrosis by up-regulating expression of indoleamine 2,3-dioxygenase-1 (IDO1).
Chen L, Cheng S, Ying J, Zhang Q, Wang C, Wu H, Wang Y, Zhang H, Wang J, Ye J, Zhang L
Toxicology letters 2024 Dec;402:44-55
Toxicology letters 2024 Dec;402:44-55
Pachymic acid ameliorates bleomycin-induced pulmonary fibrosis through inhibiting endoplasmic reticulum stress in rats.
Li L, Jin RJ, Ji L
Environmental toxicology 2024 Dec;39(12):5382-5390
Environmental toxicology 2024 Dec;39(12):5382-5390
Engineering of phosphatidylserine-targeting ROS-responsive polymeric prodrug for the repair of ischemia-reperfusion-induced acute kidney injury.
Wang JH, Mao HB, Hu JB, Cheng S, Su H
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:1100-1114
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:1100-1114
Aryl Hydrocarbon Receptor Alleviates Hepatic Fibrosis by Inducing Hepatic Stellate Cell Ferroptosis.
Liu S
Journal of cellular and molecular medicine 2024 Dec;28(23):e70278
Journal of cellular and molecular medicine 2024 Dec;28(23):e70278
Spatial dimension cues derived from fibrous scaffolds trigger mechanical activation to potentiate the paracrine and regenerative functions of MSCs via the FAK-PI3K/AKT axis.
Xu S, Zhang M, Wang R, Zhang J, Wang C, Xie L, Zhao W
Acta biomaterialia 2024 Dec;190:273-292
Acta biomaterialia 2024 Dec;190:273-292
Sec13 promotes glycolysis by inhibiting Ubqln1 mediated Pgm1 ubiquitination in ALI.
Wu D, Zhang H, Li F, Liu S, Wang Y, Zhang Z, Wang J, Wu Q
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167475
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167475
The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination.
Zhao Y, Zheng G, Yang S, Liu S, Wu Y, Miao Y, Liang Z, Hua Y, Zhang J, Shi J, Li D, Cheng Y, Zhang Y, Chen Y, Fan G, Ma C
British journal of pharmacology 2024 Dec;181(23):4822-4844
British journal of pharmacology 2024 Dec;181(23):4822-4844
The role and mechanism of P2X7R in cirrhotic cardiomyopathy.
Shao Z, Ding X, Zhou Y, Zhou J, Luo Y, Wu D, Dai Y, Qian L, Wang R, Yu Z
Molecular immunology 2024 Dec;176:49-59
Molecular immunology 2024 Dec;176:49-59
Sodium cromoglycate exerts anti-pulmonary fibrosis effects by targeting the Keap1 protein to activate Nrf2 signaling.
Liu X, Huang Y, Zhao X, Guan Y, Li Y, Yuan L, Wang C, Ma C, Ma E
Bioorganic chemistry 2024 Dec;153:107961
Bioorganic chemistry 2024 Dec;153:107961
The mechanism of α2-macroglobulin against oxidative stress and promoting cell proliferation in intervertebral disc degeneration.
Liang H, Wang Y
Bioengineered 2024 Dec;15(1):2011638
Bioengineered 2024 Dec;15(1):2011638
Green tea polyphenol alleviates silica particle-induced lung injury by suppressing IL-17/NF-κB p65 signaling-driven inflammation.
Xu Y, Ding Q, Xie Y, Zhang Q, Zhou Y, Sun H, Qian R, Wang L, Chen X, Gao Y, Yao Y, Xiao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156238
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156238
Suyin Detoxification Granule alleviates trimethylamine N-oxide-induced tubular ferroptosis and renal fibrosis to prevent chronic kidney disease progression.
Ge H, Wei Y, Zhang W, Yong C, Chen Y, Zhou E
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156195
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156195
Jia Wei Qingxin Lotus Seed Drink ameliorates epithelial mesenchymal transition injury in diabetic kidney disease via inhibition of JMJD1C/SP1/ZEB1 signaling pathway.
Xie J, Lin H, Jin F, Luo Y, Yang P, Song J, Yao W, Lin W, Yuan D, Zuo A, Sun J, Wang M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156142
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156142
Myricetin ameliorates airway inflammation and remodeling in asthma by activating Sirt1 to regulate the JNK/Smad3 pathway.
Huang D, Bai S, Qiu G, Jiang C, Huang M, Wang Y, Zhong M, Fang J, Cheng J, Zhao X, Wu B, Wu D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156044
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156044
β-sitosterol alleviates pulmonary arterial hypertension by altering smooth muscle cell phenotype and DNA damage/cGAS/STING signaling.
Li J, Meng ZY, Wen H, Lu CH, Qin Y, Xie YM, Chen Q, Lv JH, Huang F, Zeng ZY
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156030
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156030
Chlorogenic acid alleviate kidney fibrosis through regulating TLR4/NF-қB mediated oxidative stress and inflammation.
Jiao H, Zhang M, Xu W, Pan T, Luan J, Zhao Y, Zhang Z
Journal of ethnopharmacology 2024 Dec 5;335:118693
Journal of ethnopharmacology 2024 Dec 5;335:118693
Skeletal muscle-derived musclin attenuates glycolysis, oxidative stress, and pulmonary hypertension through the NPR3/AKT/mTORC1 pathway.
Sun X, Wang J, Xiao Y, Li D, Wang Q, Guo W, Yang Y
Acta biochimica et biophysica Sinica 2024 Dec 4;57(6):981-994
Acta biochimica et biophysica Sinica 2024 Dec 4;57(6):981-994
Transcriptional landscape and predictive potential of long noncoding RNAs in peritoneal recurrence of gastric cancer.
Cai XX, Chen GM, Zheng ZQ, Yin YX, Wang S, Qiao L, Chen XJ, Zhao BW, Duan JL, Liang CC, Zhang RP, Wei CZ, Zhang FY, Huang BW, Liu ZX, Zhou ZW, Xie D, Cai MY, Yuan SQ, Li YF, Nie RC
Molecular cancer 2024 Dec 30;23(1):284
Molecular cancer 2024 Dec 30;23(1):284
Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM.
Li J, Tian Z, Zhang T, Jin J, Zhang X, Xie P, Lin H, Gu J, Wu Y, Wang X, Zhang S, Yan X, Guo D, Wang Z, Zhang Q
Cellular & molecular biology letters 2024 Dec 3;29(1):148
Cellular & molecular biology letters 2024 Dec 3;29(1):148
Dual rectification of metabolism abnormality in pancreatic cancer by a programmed nanomedicine.
Wu B, Wang Z, Liu J, Li N, Wang X, Bai H, Wang C, Shi J, Zhang S, Song J, Li Y, Nie G
Nature communications 2024 Dec 3;15(1):10526
Nature communications 2024 Dec 3;15(1):10526
Intervention effect of regulating GABA-A receptor activity on the formation of experimental abdominal aortic aneurysm in rats.
Zhu JX, Zhou C, Huang LZ, Guo JW, Yin NP, Yang F, Zhang YD, Yang Y
Scientific reports 2024 Dec 28;14(1):31388
Scientific reports 2024 Dec 28;14(1):31388
Hypoxia-induced TPC2 transcription and glycosylation aggravates pulmonary arterial hypertension by blocking autophagy flux.
Li C, Li C, Jiang Y, Liu M, Yang C, Lu J, Jiang Y
Scientific reports 2024 Dec 28;14(1):31223
Scientific reports 2024 Dec 28;14(1):31223
Notoginsenoside R1-Protocatechuic aldehyde reduces vascular inflammation and calcification through increasing the release of nitric oxide to inhibit TGFβR1-YAP/TAZ pathway in vascular smooth muscle cells.
Cui X, Zhang L, Lin L, Hu Y, Zhang M, Sun B, Zhang Z, Lu M, Guan X, Hao J, Li Y, Li C
International immunopharmacology 2024 Dec 25;143(Pt 3):113574
International immunopharmacology 2024 Dec 25;143(Pt 3):113574
The bach1/G9a/Slc7a11 axis epigenetically promotes renal fibrosis by mediated ferroptosis.
Yao X, Yang S, Chen L, Lin F, Ruan Y, Rao T, Cheng F
International immunopharmacology 2024 Dec 25;143(Pt 1):113363
International immunopharmacology 2024 Dec 25;143(Pt 1):113363
Human umbilical cord mesenchymal stem cells enhance liver regeneration and decrease collagen content in fibrosis mice after partial hepatectomy by activating Wnt/β-catenin signaling.
Li X, Feng J, Cheng H, Jin N, Jin S, Liu Z, Xu J, Xie J
Acta biochimica et biophysica Sinica 2024 Dec 23;57(4):604-615
Acta biochimica et biophysica Sinica 2024 Dec 23;57(4):604-615
Identification of key mitochondria-related genes and their potential crosstalk role with immune pattern in Idiopathic pulmonary fibrosis.
Huang J, Wang X, Zeng Y, Xu H, Zhang S, Ding Z, Guo R
Gene 2024 Dec 20;930:148840
Gene 2024 Dec 20;930:148840
CD146⁺ Endothelial Cells Facilitate Renal Interstitial Fibrosis Through Endothelial-to-Mesenchymal Transition.
Zhang H, Zhang L, Tian D, Bai Y, Feng Y, Liu W, Diao Z
Annals of transplantation 2024 Dec 10;29:e945917
Annals of transplantation 2024 Dec 10;29:e945917
Pharmacodynamic insights into maresin 1: Enhancing flap viability via the keap1/Nrf2 axis to control ROS-driven apoptosis and ferroptosis.
Fang P, Cheng S, Lai Y, Ma X, Lu K, Lu J, Li G, Yang E, Yang N, Gao W, Jiang R
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Dec 1;203:106923
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024 Dec 1;203:106923
TGFβ2 mediates oxidative stress-induced epithelial-to-mesenchymal transition of bladder smooth muscle.
Geng J, Zhang X, Zhang Y, Meng X, Sun J, Zhou B, Ma J
In vitro cellular & developmental biology. Animal 2024 Aug;60(7):793-804
In vitro cellular & developmental biology. Animal 2024 Aug;60(7):793-804
Lycorine relieves the CCl(4)-induced liver fibrosis mainly via the JAK2/STAT3 and PI3K/AKT signaling pathways.
Tang Y, Zhu Z, Li M, Gao L, Wu X, Chen J, Zhang Y, Zhao H, Xiao Z
Toxicology and applied pharmacology 2024 Aug;489:117017
Toxicology and applied pharmacology 2024 Aug;489:117017
Serum deprivation protein response intervenes in the proliferation, motility, and extracellular matrix production in keloid fibroblasts by blocking the amplification of TGF-β1/SMAD signal cascade via ERK1/2.
Li P, Han M, Wang L, Gao C
Toxicology and applied pharmacology 2024 Aug;489:117012
Toxicology and applied pharmacology 2024 Aug;489:117012
A novel protein encoded by circLARP1B promotes the proliferation and migration of vascular smooth muscle cells by suppressing cAMP signaling.
Lu P, Fan J, Li B, Wang X, Song M
Atherosclerosis 2024 Aug;395:117575
Atherosclerosis 2024 Aug;395:117575
Macroscopic and histological examination of human bridging veins.
Cheshire EC, Harris NC, Malcomson RDG, Amoroso JM, Moreton JE, Biggs MJP
Forensic science international 2024 Aug;361:112080
Forensic science international 2024 Aug;361:112080
Polydatin attenuates diabetic renal inflammatory fibrosis via the inhibition of STING pathway.
Liang L, Zeng J, Liu R, Zheng Z, Lyu D, Zhang X, Wen M, Li M, Xiao H, Sun X, Li M, Huang H
Biochemical pharmacology 2024 Aug;226:116373
Biochemical pharmacology 2024 Aug;226:116373
Aldehyde Dehydrogenase 2 Deficiency Aggravates Lung Fibrosis through Mitochondrial Dysfunction and Aging in Fibroblasts.
Wei Y, Gao S, Li C, Huang X, Xie B, Geng J, Dai H, Wang C
The American journal of pathology 2024 Aug;194(8):1458-1477
The American journal of pathology 2024 Aug;194(8):1458-1477
Changes in PI3K/AKT and NRF2/HO-1 signaling expression and intestinal microbiota in bleomycin-induced pulmonary fibrosis.
Li C, Cao Y, Peng Y, Ma T, Wu F, Hua Y, Wang X, Bai T, Wei Y, Ji P
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Aug;190:114796
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Aug;190:114796
Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin damage repair after burn injury.
Zhou S, Guo L, Cui X, Zhang X, Yang Y, Zhang M, Zhang P
Cellular signalling 2024 Aug;120:111217
Cellular signalling 2024 Aug;120:111217
Tea polyphenol nanoparticles enable targeted siRNA delivery and multi-bioactive therapy for abdominal aortic aneurysms.
Wu Z, Zhang P, Yue J, Wang Q, Zhuang P, Jehan S, Fan L, Xue J, Zhou W, Wang H
Journal of nanobiotechnology 2024 Aug 8;22(1):471
Journal of nanobiotechnology 2024 Aug 8;22(1):471
Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis.
Mo C, Li H, Yan M, Xu S, Wu J, Li J, Yang X, Li Y, Yang J, Su X, Liu J, Wu C, Wang Y, Dong H, Chen L, Dai L, Zhang M, Pu Q, Yang L, Ye T, Cao Z, Ding BS
Cell metabolism 2024 Aug 6;36(8):1839-1857.e12
Cell metabolism 2024 Aug 6;36(8):1839-1857.e12
Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer.
Jiang Y, Wang Y, Chen G, Sun F, Wu Q, Huang Q, Zeng D, Qiu W, Wang J, Yao Z, Liang B, Li S, Wu J, Huang N, Wang Y, Chen J, Zhai X, Huang L, Xu B, Yamamoto M, Tsukamoto T, Nomura S, Liao W, Shi M
Cell metabolism 2024 Aug 6;36(8):1806-1822.e11
Cell metabolism 2024 Aug 6;36(8):1806-1822.e11
Titanium nanoparticles released from orthopedic implants induce muscle fibrosis via activation of SNAI2.
Zhang G, Deng L, Jiang Z, Xiang G, Zeng Z, Zhang H, Wang Y
Journal of nanobiotechnology 2024 Aug 30;22(1):522
Journal of nanobiotechnology 2024 Aug 30;22(1):522
Deficiency of flavin-containing monooxygenase 3 protects kidney function after ischemia-reperfusion in mice.
Wang J, Wang W, Zhang J, Xiao F, Li Z, Xu P, Wang H, Du H, Liu S, Li H, Zhang X, Chen S, Gao Z, Wang S, Wang J, Song M
Communications biology 2024 Aug 27;7(1):1054
Communications biology 2024 Aug 27;7(1):1054
Schnurri-3 inhibition rescues skeletal fragility and vascular skeletal stem cell niche pathology in the OIM model of osteogenesis imperfecta.
Li N, Shi B, Li Z, Han J, Sun J, Huang H, Yallowitz AR, Bok S, Xiao S, Wu Z, Chen Y, Xu Y, Qin T, Huang R, Zheng H, Shen R, Meng L, Greenblatt MB, Xu R
Bone research 2024 Aug 26;12(1):46
Bone research 2024 Aug 26;12(1):46
Cryptotanshinone alleviates liver fibrosis via inhibiting STAT3/CPT1A-dependent fatty acid oxidation in hepatic stellate cells.
Li Z, Zheng Y, Zhang L, Xu E
Chemico-biological interactions 2024 Aug 25;399:111119
Chemico-biological interactions 2024 Aug 25;399:111119
Role of gut microbiota in Crohn's disease pathogenesis: Insights from fecal microbiota transplantation in mouse model.
Wu Q, Yuan LW, Yang LC, Zhang YW, Yao HC, Peng LX, Yao BJ, Jiang ZX
World journal of gastroenterology 2024 Aug 21;30(31):3689-3704
World journal of gastroenterology 2024 Aug 21;30(31):3689-3704
The SGLT2 inhibitor dapagliflozin ameliorates renal fibrosis in hyperuricemic nephropathy.
Hu H, Li W, Hao Y, Peng Z, Zou Z, Wei J, Zhou Y, Liang W, Cao Y
Cell reports. Medicine 2024 Aug 20;5(8):101690
Cell reports. Medicine 2024 Aug 20;5(8):101690
miR-450a-2-3p targets ERK(1/2) to ameliorate ISO-induced cardiac fibrosis in mice.
Liu L, Luo F
Genes & nutrition 2024 Aug 19;19(1):16
Genes & nutrition 2024 Aug 19;19(1):16
The role and mechanism of thrombospondin-4 in pulmonary arterial hypertension associated with congenital heart disease.
Zeng H, Lan B, Li B, Xie H, Zhao E, Liu X, Xue X, Sun J, Su L, Zhang Y
Respiratory research 2024 Aug 17;25(1):313
Respiratory research 2024 Aug 17;25(1):313
Catalpol inhibits HHcy-induced EndMT in endothelial cells by modulating ROS/NF-κB signaling.
Wu C, Li Y, Liu S, Wang L, Wang X
BMC cardiovascular disorders 2024 Aug 16;24(1):431
BMC cardiovascular disorders 2024 Aug 16;24(1):431
Potential mechanisms of aortic medial degeneration promoted by co-exposure to microplastics and lead.
Xie X, Wang K, Shen X, Li X, Wang S, Yuan S, Li B, Wang Z
Journal of hazardous materials 2024 Aug 15;475:134854
Journal of hazardous materials 2024 Aug 15;475:134854
Dexamethasone induces trabecular meshwork cell myofibroblast transdifferentiation through ARHGEF26.
Zhu M, Deng X, Zhang N, Zhang P, Lai C, Cai S, Huang J, Chen X, Liu Y, Zeng W, Ke M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 15;38(15):e23848
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 15;38(15):e23848
The antihypertensive effect of Alizarin is achieved by activating VEGFR2/eNOS pathway, attenuating oxidative stress-induced mitochondrial damage and premature senescence.
Qian YW, Guo YQ, Li YL, Wang Y, Guo S, Niu QQ, Zhu ML, Li P
Life sciences 2024 Aug 15;351:122862
Life sciences 2024 Aug 15;351:122862
A novel PDGFR inhibitor WQ-C-401 prevents pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension.
Huang W, Zhou H, He Y, Wang A, Wang B, Chen Y, Liu C, Wang H, Xie W, Kong H
Experimental cell research 2024 Aug 1;441(1):114154
Experimental cell research 2024 Aug 1;441(1):114154
Asprosin contributes to vascular remodeling in hypertensive rats via superoxide signaling.
Xu ZQ, Li XZ, Zhu R, Ge R, Wei H, Shi HW, Wang Z, Yang C, Yang YW, Lu XJ, Chen AD, Zhu GQ, Tan X
Journal of hypertension 2024 Aug 1;42(8):1427-1439
Journal of hypertension 2024 Aug 1;42(8):1427-1439
Generation of human induced pluripotent stem cell line from a patient with restrictive cardiomyopathy.
Li J, Jiang J, Ye L, Lian Z, Gong H, Lei W, Dai Y, Hu S
Stem cell research 2024 Apr;76:103370
Stem cell research 2024 Apr;76:103370
Endothelial H(2)S-AMPK dysfunction upregulates the angiocrine factor PAI-1 and contributes to lung fibrosis.
Chen X, Wang H, Wu C, Li X, Huang X, Ren Y, Pu Q, Cao Z, Tang X, Ding BS
Redox biology 2024 Apr;70:103038
Redox biology 2024 Apr;70:103038
Exosomes derived from bone marrow mesenchymal stem cells alleviate biliary ischemia reperfusion injury in fatty liver transplantation by inhibiting ferroptosis.
Tian X, Wu L, Li X, Zheng W, Zuo H, Song H
Molecular and cellular biochemistry 2024 Apr;479(4):881-894
Molecular and cellular biochemistry 2024 Apr;479(4):881-894
DsbA-L ameliorates renal aging and renal fibrosis by maintaining mitochondrial homeostasis.
Yang M, Liu Y, Luo SL, Liu CB, Jiang N, Li CR, Zhao H, Han YC, Chen W, Li L, Sun L
Acta pharmacologica Sinica 2024 Apr;45(4):777-789
Acta pharmacologica Sinica 2024 Apr;45(4):777-789
BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway.
Zhao JL, Zhao L, Zhan QN, Liu M, Zhang T, Chu WW
Current medical science 2024 Apr;44(2):333-345
Current medical science 2024 Apr;44(2):333-345
Bone morphogenetic protein 6 (BMP6) antagonises experimental proliferative vitreoretinopathy established by TGF-β2 stimulation in retinal pigment epithelial cells through modulation of the p38 and JNK MAPK pathways.
Liu X, Liu M, Chen L
Cell and tissue research 2024 Apr;396(1):103-117
Cell and tissue research 2024 Apr;396(1):103-117
M2 macrophage-derived paracrine factor TNFSF13 affects the fibrogenic alterations in endothelial cells and cardiac fibroblasts by mediating the NF-κB and Akt pathway.
Tan X, Wang J, Liu X, Xie G, Ouyang F
Journal of biochemical and molecular toxicology 2024 Apr;38(4):e23707
Journal of biochemical and molecular toxicology 2024 Apr;38(4):e23707
Lipin-1 deficiency deteriorates defect of fatty acid β-oxidation and lipid-related kidney damage in diabetic kidney disease.
Lin S, Wang L, Jia Y, Sun Y, Qiao P, Quan Y, Liu J, Hu H, Yang B, Zhou H
Translational research : the journal of laboratory and clinical medicine 2024 Apr;266:1-15
Translational research : the journal of laboratory and clinical medicine 2024 Apr;266:1-15
Antler thymosin β10 reduces liver fibrosis via inhibiting TGF-β1/SMAD pathway.
Zhang G, Shi L, Li J, Ren J, Wang D, Guo X, Guo Q, Li C
International journal of biological macromolecules 2024 Apr;264(Pt 1):130502
International journal of biological macromolecules 2024 Apr;264(Pt 1):130502
Polyvinyl alcohol/carboxymethyl chitosan-based hydrogels loaded with taxifolin liposomes promote diabetic wound healing by inhibiting inflammation and regulating autophagy.
Ding Q, Liu X, Liu X, Chai G, Wang N, Ma S, Zhang L, Zhang S, Yang J, Wang Y, Shen L, Ding C, Liu W
International journal of biological macromolecules 2024 Apr;263(Pt 1):130226
International journal of biological macromolecules 2024 Apr;263(Pt 1):130226
Antibiotic bone cement accelerates diabetic foot wound healing: Elucidating the role of ROCK1 protein expression.
Yang C, Wang D
International wound journal 2024 Apr;21(4):e14590
International wound journal 2024 Apr;21(4):e14590
Cellular nucleic acid binding protein facilitates cardiac repair after myocardial infarction by activating β-catenin signaling.
Du C, Zhao S, Shan T, Han X, Jiang Q, Chen J, Gu L, Wei T, Yang T, Wang S, Wang H, Guo X, Wang L
Journal of molecular and cellular cardiology 2024 Apr;189:66-82
Journal of molecular and cellular cardiology 2024 Apr;189:66-82
Icariin alleviates diabetic renal interstitial fibrosis aggravation by inhibiting miR-320a-3p targeting BMP6.
Wang K, Hou M, Qiao C, Duan Y, Tao R, Wang X, Xiao K, Liu S, Zhao H, Wang J, Jia Z, Ding X
Journal of pharmacological sciences 2024 Apr;154(4):316-325
Journal of pharmacological sciences 2024 Apr;154(4):316-325
CXCL4/CXCR3 axis regulates cardiac fibrosis by activating TGF-β1/Smad2/3 signaling in mouse viral myocarditis.
Wei J, Wang DF, Cui CC, Tan JJ, Peng MY, Lu HX
Immunity, inflammation and disease 2024 Apr;12(4):e1237
Immunity, inflammation and disease 2024 Apr;12(4):e1237
Low-Frequency Ultrasound Sensitive Piezo1 Channels Regulate Keloid-Related Characteristics of Fibroblasts.
Jiang Z, Chen Z, Xu Y, Li H, Li Y, Peng L, Shan H, Liu X, Wu H, Wu L, Jian D, Su J, Chen X, Chen Z, Zhao S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2305489
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2305489
PI3Kδ Mediates Fibrosis by Patient-Derived Vitreous.
Liu D, Yan B, Yin Y, Chen F, Guo C, Li Q, Liu J, Pu L, Wu W, Luo J
Laboratory investigation; a journal of technical methods and pathology 2024 Apr;104(4):102026
Laboratory investigation; a journal of technical methods and pathology 2024 Apr;104(4):102026
NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin.
Zeng Q, Wen BB, Liu X, Luo YY, Hu ZG, Huang L, Zhang XH, Huang XT, Zhou TT, Sang XX, Luo YY, Xiong DY, Luo ZQ, Liu W, Tang SY
Chinese medicine 2024 Apr 8;19(1):60
Chinese medicine 2024 Apr 8;19(1):60
Global proteomic analysis reveals lysine succinylation is involved in the pathogenesis of hypertrophic scar.
Qiu K, Tian Y, Guo C, Liu O, Shi Y, Liu D, Luo T
Journal of proteomics 2024 Apr 30;298:105155
Journal of proteomics 2024 Apr 30;298:105155
DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis.
Chen SJ, Yu F, Feng X, Li Q, Jiang YH, Zhao LQ, Cheng PP, Wang M, Song LJ, Liang LM, He XL, Xiong L, Xiang F, Wang X, Ye H, Ma WL
Cell communication and signaling : CCS 2024 Apr 26;22(1):245
Cell communication and signaling : CCS 2024 Apr 26;22(1):245
ACAT2 suppresses the ubiquitination of YAP1 to enhance the proliferation and metastasis ability of gastric cancer via the upregulation of SETD7.
Zhang M, Cai F, Guo J, Liu S, Ma G, Cai M, Zhang R, Deng J
Cell death & disease 2024 Apr 26;15(4):297
Cell death & disease 2024 Apr 26;15(4):297
SirT7-mediated transcription of fascin in hyperglycemic glomerular endothelial cells contributes to EndMT in diabetic nephropathy.
Wu M, Hao Y, Wu X, Zhu M, Chen X, Qi J, Yu Z, Xu H
Acta biochimica et biophysica Sinica 2024 Apr 25;56(4):586-596
Acta biochimica et biophysica Sinica 2024 Apr 25;56(4):586-596
Jin-Gui-Shen-Qi Wan alleviates fibrosis in mouse diabetic nephropathy via MHC class II.
Liang D, Liu L, Qi Y, Nan F, Huang J, Tang S, Tang J, Chen N
Journal of ethnopharmacology 2024 Apr 24;324:117745
Journal of ethnopharmacology 2024 Apr 24;324:117745
Leech extract alleviates idiopathic pulmonary fibrosis by TGF-β1/Smad3 signaling pathway.
Zhang Y, Lu YB, Zhu WJ, Gong XX, Qian R, Lu YJ, Li Y, Yao WF, Bao BH, Zhang Y, Zhang L, Cheng FF
Journal of ethnopharmacology 2024 Apr 24;324:117737
Journal of ethnopharmacology 2024 Apr 24;324:117737
Baicalein alleviates intrahepatic cholestasis by regulating bile acid metabolism via an FXR-dependent manner.
Huang W, Qian Y, Lin J, Wang F, Kong X, Tan W
Biochemical and biophysical research communications 2024 Apr 23;705:149670
Biochemical and biophysical research communications 2024 Apr 23;705:149670
AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis.
Zhao J, Yang T, Yi J, Hu H, Lai Q, Nie L, Liu M, Chu C, Yang J
iScience 2024 Apr 19;27(4):109321
iScience 2024 Apr 19;27(4):109321
Human Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Alleviate Hypoxia-Induced Pulmonary Arterial Hypertension in Mice Via Macrophages.
Liu H, Zhang Q, Liu C, Zhang Y, Wang Y, Huang P, Ma L, Ge R
Stem cells (Dayton, Ohio) 2024 Apr 15;42(4):329-345
Stem cells (Dayton, Ohio) 2024 Apr 15;42(4):329-345
Improving impact of heparan sulfate on the endothelial glycocalyx abnormalities in atherosclerosis as revealed by glycan-protein interactome.
Chen Q, Xu X, Xie S, Sheng A, Han N, Tian Z, Wang X, Li F, Linhardt RJ, Zhang F, Jin L, Zhang Q, Chi L
Carbohydrate polymers 2024 Apr 15;330:121834
Carbohydrate polymers 2024 Apr 15;330:121834
Incorporating machine learning and PPI networks to identify mitochondrial fission-related immune markers in abdominal aortic aneurysms.
Liu YJ, Li R, Xiao D, Yang C, Li YL, Chen JL, Wang Z, Zhao XG, Shan ZG
Heliyon 2024 Apr 15;10(7):e27989
Heliyon 2024 Apr 15;10(7):e27989
FBXL8 inhibits post-myocardial infarction cardiac fibrosis by targeting Snail1 for ubiquitin-proteasome degradation.
Li Y, Zuo C, Wu X, Ding Y, Wei Y, Chen S, Lu X, Xu J, Liu S, Zhou G, Cai L
Cell death & disease 2024 Apr 13;15(4):263
Cell death & disease 2024 Apr 13;15(4):263
Patient-Derived Exosomes as siRNA Carriers in Ovarian Cancer Treatment.
Shimizu A, Sawada K, Kobayashi M, Oi Y, Oride T, Kinose Y, Kodama M, Hashimoto K, Kimura T
Cancers 2024 Apr 12;16(8)
Cancers 2024 Apr 12;16(8)
Liquiritigenin Attenuated Collagen-Induced Arthritis and Cardiac Complication via Inflammation and Fibrosis Inhibition in Mice.
Ning X, Ni Y, Cao J, Zhang H
Chemical & pharmaceutical bulletin 2023;71(4):269-276
Chemical & pharmaceutical bulletin 2023;71(4):269-276
Trimethylamine N-oxide Promotes Atherosclerosis by Regulating Low-Density Lipoprotein-Induced Autophagy in Vascular Smooth Muscle Cells Through PI3K/AKT/mTOR Pathway.
Shi G, Zeng L, Shi J, Chen Y
International heart journal 2023;64(3):462-469
International heart journal 2023;64(3):462-469
Isolation and Cultivation of Vascular Smooth Muscle Cells from the Mouse Circle of Willis.
Chang W, Li Y, Liu F, Zang K, Zhang P, Qu S, Zhao J, Xue J
Journal of vascular research 2023;60(4):234-244
Journal of vascular research 2023;60(4):234-244
Echinacoside alleviates airway remodeling and inflammation in an ovalbumin-induced neonatal mouse model of asthma by modulating the SIRT1-NF-κB pathway.
Pan Y, Liu Y
Allergologia et immunopathologia 2023;51(4):71-77
Allergologia et immunopathologia 2023;51(4):71-77
Propofol improves ischemia reperfusion-induced liver fibrosis by regulating lncRNA HOXA11-AS.
Luo J, Liu J, Mou Y, Luo F, Liao Q, Liao Y
The Journal of toxicological sciences 2023;48(6):345-354
The Journal of toxicological sciences 2023;48(6):345-354
Chlorogenic Acid Inhibited Epithelial-Mesenchymal Transition to Treat Pulmonary Fibrosis through Modulating Autophagy.
Mao X, Xie X, Ma J, Wei Y, Huang Z, Wang T, Zhu J, Wang Y, Zhao H, Hua J
Biological & pharmaceutical bulletin 2023;46(7):929-938
Biological & pharmaceutical bulletin 2023;46(7):929-938
Indirubin alleviates CCl(4)-induced liver fibrosis by regulation of TGF-β-mediated signaling pathways.
Li X, Yao Y, Wei L
Iranian journal of basic medical sciences 2023;26(9):1047-1052
Iranian journal of basic medical sciences 2023;26(9):1047-1052
Up-regulated SPP1 increases the risk from IPF to lung cancer via activating the pro-tumor macrophages.
Chen T, Guo J, Ai L, Wang Y, Wang Y, Chen B, Liu M, Zhuang S, Liu K, Zhao Z, Liang H, Gu Y
Computational and structural biotechnology journal 2023;21:5751-5764
Computational and structural biotechnology journal 2023;21:5751-5764
miR-145 Alleviates Smooth Muscle Cell Phenotype Transition via ADAM17-Mediated ACE2 Shedding.
Wen J, Tang B, Guo L, Chen W, Tang X
International journal of hypertension 2023;2023:9497716
International journal of hypertension 2023;2023:9497716
hucMSC-Ex Alleviates IBD-Associated Intestinal Fibrosis by Inhibiting ERK Phosphorylation in Intestinal Fibroblasts.
Wang Y, Zhang Y, Lu B, Xi J, Ocansey DKW, Mao F, Hao D, Yan Y
Stem cells international 2023;2023:2828981
Stem cells international 2023;2023:2828981
Renalase Prevents Renal Fibrosis by Inhibiting Endoplasmic Reticulum Stress and Down-Regulating GSK-3β/Snail Signaling.
Wu Y, Bai Y, Feng Y, Zhang Q, Diao Z, Liu W
International journal of medical sciences 2023;20(5):669-681
International journal of medical sciences 2023;20(5):669-681
FAT10 Silencing Prevents Liver Fibrosis through Regulating SIRT1 Expression in Hepatic Stellate Cells.
Zheng W, Guan F, Xu G, Yu Y, Xiao J, Huang X
International journal of medical sciences 2023;20(4):557-565
International journal of medical sciences 2023;20(4):557-565
Sarcoma protein kinase inhibition alleviates liver fibrosis by promoting hepatic stellate cells ferroptosis.
Cheng Z, Zhang X, Chen P, Wang H, Wang K, Shen Y
Open life sciences 2023;18(1):20220781
Open life sciences 2023;18(1):20220781
Adiponectin inhibits TGF-β1-induced skin fibroblast proliferation and phenotype transformation via the p38 MAPK signaling pathway.
Wang X, Yan X, Huang F, Wu L
Open life sciences 2023;18(1):20220679
Open life sciences 2023;18(1):20220679
Exosome Derived from Mesenchymal Stem Cells Alleviates Hypertrophic Scar by Inhibiting the Fibroblasts via TNFSF-13/HSPG2 Signaling Pathway.
Zhang H, Zang C, Zhao W, Zhang L, Liu R, Feng Z, Wu J, Cui R
International journal of nanomedicine 2023;18:7047-7063
International journal of nanomedicine 2023;18:7047-7063
Identification and Characterization of a Novel Nanobody Against Human CTGF to Reveal Its Antifibrotic Effect in an in vitro Model of Liver Fibrosis.
Liu R, Zhu M, Chen J, Gai J, Huang J, Zhou Y, Wan Y, Tu C
International journal of nanomedicine 2023;18:5407-5422
International journal of nanomedicine 2023;18:5407-5422
Glycosylation-Engineered Platelet Membrane-Coated Interleukin 10 Nanoparticles for Targeted Inhibition of Vascular Restenosis.
Li F, Rong Z, Chen T, Wang P, Di X, Ni L, Liu C
International journal of nanomedicine 2023;18:5011-5030
International journal of nanomedicine 2023;18:5011-5030
Co-Delivery Nanomicelles for Potentiating TNBC Immunotherapy by Synergetically Reshaping CAFs-Mediated Tumor Stroma and Reprogramming Immunosuppressive Microenvironment.
Zhang Y, Han X, Wang K, Liu D, Ding X, Hu Z, Wang J
International journal of nanomedicine 2023;18:4329-4346
International journal of nanomedicine 2023;18:4329-4346
Irisin Ameliorates Renal Tubulointerstitial Fibrosis by Regulating the Smad4/β-Catenin Pathway in Diabetic Mice.
Yang Z, Wei J, Wang Y, Du Y, Song S, Li J, Su Z, Shi Y, Wu H
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:1577-1593
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:1577-1593
GLIS2 Prevents Hepatic Fibrosis by Competitively Binding HDAC3 to Inhibit Hepatic Stellate Cell Activation.
Zhang H, Zhou P, Xing W, Chen L, Zhou Y, Yang H, Fu K, Liu Z
Cellular and molecular gastroenterology and hepatology 2023;15(2):355-372
Cellular and molecular gastroenterology and hepatology 2023;15(2):355-372
Mannan-Binding Lectin Reduces Epithelial-Mesenchymal Transition in Pulmonary Fibrosis via Inactivating the Store-Operated Calcium Entry Machinery.
Liu Y, Xie X, Wang P, Luo J, Chen Y, Xu Q, Zhou J, Lu X, Zhao J, Chen Z, Zuo D
Journal of innate immunity 2023;15(1):37-49
Journal of innate immunity 2023;15(1):37-49
A comprehensive cuproptosis score and associated gene signatures reveal prognostic and immunological features of idiopathic pulmonary fibrosis.
Jing C, Fu R, Liu X, Zang G, Zhu X, Wang C, Zhang W
Frontiers in immunology 2023;14:1268141
Frontiers in immunology 2023;14:1268141
Four novel mutations identification in 17 beta-hydroxysteroid dehydrogenase-3 deficiency and our clinical experience: possible benefits of early treatment.
Wang Y, Xu Y, Zhang H, Yin D, Pan Y, He X, Li S, Cheng Z, Zhu G, Zhao T, Huang H, Zhu M
Frontiers in endocrinology 2023;14:1267967
Frontiers in endocrinology 2023;14:1267967
Tangeretin attenuates bleomycin-induced pulmonary fibrosis by inhibiting epithelial-mesenchymal transition via the PI3K/Akt pathway.
Li J, Wei Q, Song K, Wang Y, Yang Y, Li M, Yu J, Su G, Peng L, Fu B, Yi P
Frontiers in pharmacology 2023;14:1247800
Frontiers in pharmacology 2023;14:1247800
The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy.
Ma Y, Chen Y, Xu H, Du N
Frontiers in immunology 2023;14:1228399
Frontiers in immunology 2023;14:1228399
APOC1 exacerbates renal fibrosis through the activation of the NF-κB signaling pathway in IgAN.
Yu K, Ding L, An X, Yang Y, Zhang X, Li L, Wang C, Bai F, Yang X
Frontiers in pharmacology 2023;14:1181435
Frontiers in pharmacology 2023;14:1181435
The role of the SGK3/TOPK signaling pathway in the transition from acute kidney injury to chronic kidney disease.
Shu H, Wang Y, Zhang H, Dong Q, Sun L, Tu Y, Liao Q, Feng L, Yao L
Frontiers in pharmacology 2023;14:1169054
Frontiers in pharmacology 2023;14:1169054
Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish.
Zou YY, Tang XB, Chen ZL, Liu B, Zheng L, Song MY, Xiao Q, Zhou ZQ, Peng XY, Tang CF
Frontiers in endocrinology 2023;14:1162485
Frontiers in endocrinology 2023;14:1162485
Apolipoprotein A-I attenuates peritoneal fibrosis associated with peritoneal dialysis by inhibiting oxidative stress and inflammation.
Lu J, Gao J, Sun J, Wang H, Sun H, Huang Q, Zhang Y, Zhong S
Frontiers in pharmacology 2023;14:1106339
Frontiers in pharmacology 2023;14:1106339
IL-12α deficiency attenuates pressure overload-induced cardiac inflammation, hypertrophy, dysfunction, and heart failure progression.
Bhattarai U, He X, Xu R, Liu X, Pan L, Sun Y, Chen JX, Chen Y
Frontiers in immunology 2023;14:1105664
Frontiers in immunology 2023;14:1105664
Aqueous extract of Amydrium sinense (Engl.) H. Li alleviates hepatic fibrosis by suppressing hepatic stellate cell activation through inhibiting Stat3 signaling.
Li J, Wu B, Zeng L, Lin Y, Chen Q, Wang H, An L, Zhang J, Chen S, Huang J, Zhan R, Zhang G
Frontiers in pharmacology 2023;14:1101703
Frontiers in pharmacology 2023;14:1101703
A strategy of local hydrogen capture and catalytic hydrogenation for enhanced therapy of chronic liver diseases.
Tao G, Liu F, Jin Z, Liu B, Wang H, Li D, Tang W, Chen Y, He Q, Qin S
Theranostics 2023;13(8):2455-2470
Theranostics 2023;13(8):2455-2470
Primary extra-gastrointestinal stromal tumor of retroperitoneum: Clinicopathologic characteristics and prognosis of six cases.
Lin J, Liao W, Wang J, Li W, Tang X, Li H, Yi X, Lu X, Chen Z, Zhu B, Feng X, Diao D
Frontiers in oncology 2023;13:1033598
Frontiers in oncology 2023;13:1033598
S-propargyl-cysteine promotes the stability of atherosclerotic plaque via maintaining vascular muscle contractile phenotype.
Ping L, Zhi-Ming L, Bi-Shan Z, Lei Z, Bo Y, Yi-Chun Z, Ming-Jie W
Frontiers in cell and developmental biology 2023;11:1291170
Frontiers in cell and developmental biology 2023;11:1291170
Effect of stem cell conditional medium-loading adhesive hydrogel on TGF-β1-induced endometrial stromal cell fibrosis.
Zhu Y, Wang T, Bao MJ, Qu XH, Li ZM
Frontiers in bioengineering and biotechnology 2023;11:1168136
Frontiers in bioengineering and biotechnology 2023;11:1168136
Engineered exosomes derived from miR-132-overexpresssing adipose stem cells promoted diabetic wound healing and skin reconstruction.
Ge L, Wang K, Lin H, Tao E, Xia W, Wang F, Mao C, Feng Y
Frontiers in bioengineering and biotechnology 2023;11:1129538
Frontiers in bioengineering and biotechnology 2023;11:1129538
Ketogenic diet alleviates renal fibrosis in mice by enhancing fatty acid oxidation through the free fatty acid receptor 3 pathway.
Qiu Y, Hu X, Xu C, Lu C, Cao R, Xie Y, Yang J
Frontiers in nutrition 2023;10:1127845
Frontiers in nutrition 2023;10:1127845
Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model.
Song X, Leonhard WN, Kanhai AA, Steinberg GR, Pei Y, Peters DJM
Frontiers in molecular biosciences 2023;10:1058825
Frontiers in molecular biosciences 2023;10:1058825
Integrative analysis of cancer-associated fibroblast signature in gastric cancer.
Zhao Z, Mak TK, Shi Y, Li K, Huo M, Zhang C
Heliyon 2023 Sep;9(9):e19217
Heliyon 2023 Sep;9(9):e19217
Knockdown of AK142426 suppresses M2 macrophage polarization and inflammation in peritoneal fibrosis via binding to c-Jun.
Shao Q, Jiang C, Zhang Q, Liu J, Jin B, Zhao M, Xia Y
The journal of gene medicine 2023 Sep;25(9):e3524
The journal of gene medicine 2023 Sep;25(9):e3524
SIRT3 regulates mitophagy in liver fibrosis through deacetylation of PINK1/NIPSNAP1.
Li R, Wang Z, Wang Y, Sun R, Zou B, Tian X, Liu D, Zhao X, Zhou J, Zhao Y, Yao J
Journal of cellular physiology 2023 Sep;238(9):2090-2102
Journal of cellular physiology 2023 Sep;238(9):2090-2102
Mining host candidate regulators of schistosomiasis-induced liver fibrosis in response to artesunate therapy through transcriptomics approach.
Yuan Y, Lv X, Wu Y, Weng Y, Dai F, Ding H, Chen R, Zheng B, Zhao W, Tong Q, Ding J, Lou D, Lai Y, Chu X, Zhao L, Lu S, Kong Q
PLoS neglected tropical diseases 2023 Sep;17(9):e0011626
PLoS neglected tropical diseases 2023 Sep;17(9):e0011626
AP39 inhibits ferroptosis by inhibiting mitochondrial autophagy through the PINK1/parkin pathway to improve myocardial fibrosis with myocardial infarction.
Yang T, Yang Q, Lai Q, Zhao J, Nie L, Liu S, Yang J, Chu C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115195
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115195
A novel onco-cardiological mouse model of lung cancer-induced cardiac dysfunction and its application in identifying potential roles of tRNA-derived small RNAs.
Wu Q, Zou S, Liu W, Liang M, Chen Y, Chang J, Liu Y, Yu X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115117
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115117
miR-32-5p induces hepatic steatosis and hyperlipidemia by triggering de novo lipogenesis.
Wang YD, Wu LL, Mai YN, Wang K, Tang Y, Wang QY, Li JY, Jiang LY, Liao ZZ, Hu C, Wang YY, Liu JJ, Liu JH, Xiao XH
Metabolism: clinical and experimental 2023 Sep;146:155660
Metabolism: clinical and experimental 2023 Sep;146:155660
SGLT2 inhibitor empagliflozin downregulates miRNA-34a-5p and targets GREM2 to inactivate hepatic stellate cells and ameliorate non-alcoholic fatty liver disease-associated fibrosis.
Shen Y, Cheng L, Xu M, Wang W, Wan Z, Xiong H, Guo W, Cai M, Xu F
Metabolism: clinical and experimental 2023 Sep;146:155657
Metabolism: clinical and experimental 2023 Sep;146:155657
Milk-derived exosomes carrying siRNA-KEAP1 promote diabetic wound healing by improving oxidative stress.
Xiang X, Chen J, Jiang T, Yan C, Kang Y, Zhang M, Xiang K, Guo J, Jiang G, Wang C, XiangXu, Yang X, Chen Z
Drug delivery and translational research 2023 Sep;13(9):2286-2296
Drug delivery and translational research 2023 Sep;13(9):2286-2296
Celastrol attenuates diabetic nephropathy by upregulating SIRT1-mediated inhibition of EZH2related wnt/β-catenin signaling.
Tang Y, Wan F, Tang X, Lin Y, Zhang H, Cao J, Yang R
International immunopharmacology 2023 Sep;122:110584
International immunopharmacology 2023 Sep;122:110584
Axitinib attenuates the progression of liver fibrosis by restoring mitochondrial function.
Li H, Zhang R, Hu Y, Li J, Yang Y, Wu D, Gu X, Zhang F, Zhou H, Yang C
International immunopharmacology 2023 Sep;122:110555
International immunopharmacology 2023 Sep;122:110555
Geniposide alleviated bile acid-associated NLRP3 inflammasome activation by regulating SIRT1/FXR signaling in bile duct ligation-induced liver fibrosis.
Qin T, Hasnat M, Wang Z, Hassan HM, Zhou Y, Yuan Z, Zhang W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154971
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154971
Mammalian cleavage factor 25 targets KLF14 to inhibit hepatic stellate cell activation and liver fibrosis.
Chen X, Shi W, Zhu L, Zhou X, Wang Y
Cellular signalling 2023 Sep;109:110752
Cellular signalling 2023 Sep;109:110752
HMGA2 knockdown alleviates the progression of nonalcoholic fatty liver disease (NAFLD) by downregulating SNAI2 expression.
Sun J, Jin X, Zhang X, Zhang B
Cellular signalling 2023 Sep;109:110741
Cellular signalling 2023 Sep;109:110741
TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5.
Wu M, Jin Q, Xu X, Fan J, Chen W, Miao M, Gu R, Zhang S, Guo Y, Huang S, Zhang Y, Zhang A, Jia Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2301753
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2301753
FNDC5 inhibits autophagy of bone marrow mesenchymal stem cells and promotes their survival after transplantation by downregulating Sp1.
Wei H, Liu S, Wang T, Li Y, Liu K, Guo Q, Li L
Cell death discovery 2023 Sep 6;9(1):336
Cell death discovery 2023 Sep 6;9(1):336
NDUFC2 deficiency exacerbates endothelial mesenchymal transformation during ischemia-reperfusion via NLRP3.
Chen J, Liu X, Bi R, Liu P, Gong W
Neuroreport 2023 Sep 6;34(13):670-676
Neuroreport 2023 Sep 6;34(13):670-676
Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation.
Liu J, Chen Y, Chen H, Wang Y, Li D, Zhang Q, Chai L, Qiu Y, Zhang J, Shen N, Wang Q, Wang J, Li M
Respiratory research 2023 Sep 6;24(1):216
Respiratory research 2023 Sep 6;24(1):216
Exosomal miR-17-5p from human embryonic stem cells prevents pulmonary fibrosis by targeting thrombospondin-2.
Liu Q, Bi Y, Song S, Zhu K, Qiao X, Wang H, Ji G
Stem cell research & therapy 2023 Sep 4;14(1):234
Stem cell research & therapy 2023 Sep 4;14(1):234
The effects of Shikonin on the hypertrophic scar of rabbit ears via the TLR4/NF-κB signaling pathway.
Liu C, Zhang H, Cui X, Wang S, Zhou Q
Cellular and molecular biology (Noisy-le-Grand, France) 2023 Sep 30;69(9):161-166
Cellular and molecular biology (Noisy-le-Grand, France) 2023 Sep 30;69(9):161-166
Curcumin ameliorates focal segmental glomerulosclerosis by inhibiting apoptosis and oxidative stress in podocytes.
Zhang H, Dong QQ, Shu HP, Tu YC, Liao QQ, Yao LJ
Archives of biochemistry and biophysics 2023 Sep 15;746:109728
Archives of biochemistry and biophysics 2023 Sep 15;746:109728
Dendrobium officinale Kimura & Migo polysaccharide inhibits hyperglycaemia-induced kidney fibrosis via the miRNA-34a-5p/SIRT1 signalling pathway.
Huang C, Yu J, Da J, Dong R, Dai L, Yang Y, Deng Y, Yuan J
Journal of ethnopharmacology 2023 Sep 15;313:116601
Journal of ethnopharmacology 2023 Sep 15;313:116601
The alcohol extracts of Sceptridium ternatum (Thunb.) Lyon exert anti-pulmonary fibrosis effect through targeting SETDB1/STAT3/p-STAT3 signaling.
Zou X, Huang Z, Zhan Z, Yuan M, Zhang Y, Liu T, Hu X, Fan W, Chen P, Qin H, Zhang S, Xia Y, Zheng S, Pan Z, Huang P
Journal of ethnopharmacology 2023 Sep 15;313:116520
Journal of ethnopharmacology 2023 Sep 15;313:116520
The effect of GelDex-S58 hydrogel on anti-conjunctival scarring after glaucoma filtration surgery.
Lin Y, Luo W, Jiang B, Lin Q, Tang M, Li X, Xie L
iScience 2023 Sep 15;26(9):107633
iScience 2023 Sep 15;26(9):107633
Selective inhibition of glycolysis in hepatic stellate cells and suppression of liver fibrogenesis with vitamin A-derivative decorated camptothecin micelles.
Xiang L, Wang X, Jiao Q, Shao Y, Luo R, Zhang J, Zheng X, Zhou S, Chen Y
Acta biomaterialia 2023 Sep 15;168:497-514
Acta biomaterialia 2023 Sep 15;168:497-514
PRDX1 Cys52Ser variant alleviates nonalcoholic steatohepatitis by reducing inflammation in mice.
Bai Z, Yin W, Liu R, Tang M, Shi X, Luo C, Xie X
Molecular metabolism 2023 Oct;76:101789
Molecular metabolism 2023 Oct;76:101789
Chronic β-adrenergic stress contributes to cardiomyopathy in rodents with collagen-induced arthritis.
Zhu ZD, Zhang M, Wang Z, Jiang CR, Huang CJ, Cheng HJ, Guan QY, Su TT, Wang MM, Gao Y, Wu HF, Wei W, Han YS, Wang QT
Acta pharmacologica Sinica 2023 Oct;44(10):1989-2003
Acta pharmacologica Sinica 2023 Oct;44(10):1989-2003
PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF-1α protein stability and gene expression.
Ma Z, Mo R, Yang P, Ding Y, Zhang H, Dong Z, Chen Y, Tan Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23215
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23215
Human-Induced Hepatocytes-Derived Extracellular Vesicles Ameliorated Liver Fibrosis in Mice Via Suppression of TGF-β1/Smad Signaling and Activation of Nrf2/HO-1 Signaling.
Liu W, Wu J, Cao H, Ma C, Wu Z, Tian Y, Ma C, Qiu H, Pan G
Stem cells and development 2023 Oct;32(19-20):638-651
Stem cells and development 2023 Oct;32(19-20):638-651
Niclosamide inhibits TGF-β1-induced fibrosis of human Tenon's fibroblasts by regulating the MAPK-ERK1/2 pathway.
Zhang L, Li W, Liu X, Guo J, Wu X, Wang J
Experimental eye research 2023 Oct;235:109628
Experimental eye research 2023 Oct;235:109628
Myeloid-specific deletion of Capns1 attenuates myocardial infarction injury via restoring mitochondrial function and inhibiting inflammasome activation.
Xiao Z, Wei X, Li M, Yang K, Chen R, Su Y, Yu Z, Liang Y, Ge J
Journal of molecular and cellular cardiology 2023 Oct;183:54-66
Journal of molecular and cellular cardiology 2023 Oct;183:54-66
M2 macrophages mediate fibrotic scar formation in the early stages after cerebral ischemia in rats.
Huang JG, Ren JX, Chen Y, Tian MF, Zhou L, Wen J, Song XS, Wu YL, Yang QH, Jiang PR, Wang JN, Yang Q
Neural regeneration research 2023 Oct;18(10):2208-2218
Neural regeneration research 2023 Oct;18(10):2208-2218
Nintedanib inhibits normal human vitreous-induced epithelial-mesenchymal transition in human retinal pigment epithelial cells.
Yin Y, Liu S, Liu H, Wu W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115403
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115403
Molecular insights of a CBP/β-catenin-signaling inhibitor on nonalcoholic steatohepatitis-induced liver fibrosis and disorder.
Yamaji K, Iwabuchi S, Tokunaga Y, Hashimoto S, Yamane D, Toyama S, Kono R, Kitab B, Tsukiyama-Kohara K, Osawa Y, Hayashi Y, Hishima T, Tateno C, Kimura K, Okanoue T, Kohara M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115379
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115379
Farnesoid X receptor activation is required for the anti-inflammatory and anti-oxidative stress effects of Alisol B 23-acetate in carbon tetrachloride-induced liver fibrosis in mice.
Zhang L, Lin W, Cai Y, Huang Z, Zhao R, Yan T, Xu H, Liu Z
International immunopharmacology 2023 Oct;123:110768
International immunopharmacology 2023 Oct;123:110768
Hierarchically Released Liquid Metal Nanoparticles for Mild Photothermal Therapy/Chemotherapy of Breast Cancer Bone Metastases via Remodeling Tumor Stromal Microenvironment.
Shen Y, Zou Y, Bie B, Lv Y
Advanced healthcare materials 2023 Oct;12(27):e2301080
Advanced healthcare materials 2023 Oct;12(27):e2301080
Sox7-positive endothelial progenitors establish coronary arteries and govern ventricular compaction.
Chiang IK, Humphrey D, Mills RJ, Kaltzis P, Pachauri S, Graus M, Saha D, Wu Z, Young P, Sim CB, Davidson T, Hernandez-Garcia A, Shaw CA, Renwick A, Scott DA, Porrello ER, Wong ES, Hudson JE, Red-Horse K, Del Monte-Nieto G, Francois M
EMBO reports 2023 Oct 9;24(10):e55043
EMBO reports 2023 Oct 9;24(10):e55043
Theaflavine inhibits hepatic stellate cell activation by modulating the PKA/LKB1/AMPK/GSK3β cascade and subsequently enhancing Nrf2 signaling.
Shu G, Sun H, Zhang T, Zhu A, Lei X, Wang C, Song A, Deng X
European journal of pharmacology 2023 Oct 5;956:175964
European journal of pharmacology 2023 Oct 5;956:175964
Fu-Zheng-Tong-Luo formula promotes autophagy and alleviates idiopathic pulmonary fibrosis by controlling the Janus kinase 2/signal transducer and activator of transcription 3 pathway.
Zhang X, Su J, Lin J, Liu L, Wu J, Yuan W, Zhang Y, Chen Q, Su ZJ, Xu G, Sun M, Zhang Y, Chen X, Zhang W
Journal of ethnopharmacology 2023 Oct 5;314:116633
Journal of ethnopharmacology 2023 Oct 5;314:116633
NLRP3 Inflammasome Activates Endothelial-to-Mesenchymal Transition via Focal Adhesion Kinase Pathway in Bleomycin-Induced Pulmonary Fibrosis.
Chen WC, Yu WK, Su VY, Hsu HS, Yang KY
International journal of molecular sciences 2023 Oct 31;24(21)
International journal of molecular sciences 2023 Oct 31;24(21)
CRTC2 activates the epithelial-mesenchymal transition of diabetic kidney disease through the CREB-Smad2/3 pathway.
Li Y, Zhang Y, Shi H, Liu X, Li Z, Zhang J, Wang X, Wang W, Tong X
Molecular medicine (Cambridge, Mass.) 2023 Oct 26;29(1):146
Molecular medicine (Cambridge, Mass.) 2023 Oct 26;29(1):146
Sodium-glucose cotransporter 2 inhibitor canagliflozin alleviates vascular calcification through suppression of nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 inflammasome.
Chen A, Lan Z, Li L, Xie L, Liu X, Yang X, Wang S, Liang Q, Dong Q, Feng L, Li Y, Ye Y, Fu M, Lu L, Yan J
Cardiovascular research 2023 Oct 24;119(13):2368-2381
Cardiovascular research 2023 Oct 24;119(13):2368-2381
Activation of acetyl-CoA synthetase 2 mediates kidney injury in diabetic nephropathy.
Lu J, Li XQ, Chen PP, Zhang JX, Liu L, Wang GH, Liu XQ, Jiang TT, Wang MY, Liu WT, Ruan XZ, Ma KL
JCI insight 2023 Oct 23;8(20)
JCI insight 2023 Oct 23;8(20)
The Dual-Mode Transition of Myofibroblasts Derived from Hepatic Stellate Cells in Liver Fibrosis.
Yan M, Xie Y, Yao J, Li X
International journal of molecular sciences 2023 Oct 23;24(20)
International journal of molecular sciences 2023 Oct 23;24(20)
Targeting ferroptosis attenuates podocytes injury and delays tubulointerstitial fibrosis in focal segmental glomerulosclerosis.
He X, Yang L, Wang M, Zhang P, Wang R, Ji D, Gao C, Xia Z
Biochemical and biophysical research communications 2023 Oct 20;678:11-16
Biochemical and biophysical research communications 2023 Oct 20;678:11-16
Single-cell transcriptome profiling reveals immune and stromal cell heterogeneity in primary Sjögren's syndrome.
Xiang N, Xu H, Zhou Z, Wang J, Cai P, Wang L, Tan Z, Zhou Y, Zhang T, Zhou J, Liu K, Luo S, Fang M, Wang G, Chen Z, Guo C, Li X
iScience 2023 Oct 20;26(10):107943
iScience 2023 Oct 20;26(10):107943
Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling.
Huang J, Xu ZF, Liu F, Song AN, Su H, Zhang C
iScience 2023 Oct 20;26(10):107940
iScience 2023 Oct 20;26(10):107940
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931
iScience 2023 Oct 20;26(10):107931
High glucose promotes benign prostatic hyperplasia by downregulating PDK4 expression.
Wei P, Lin D, Luo C, Zhang M, Deng B, Cui K, Chen Z
Scientific reports 2023 Oct 20;13(1):17910
Scientific reports 2023 Oct 20;13(1):17910
Vitamin D(3) analogue calcipotriol inhibits the profibrotic effects of transforming growth factor- β1 on pancreatic stellate cells.
Zheng M, Li H, Gao Y, Brigstock DR, Gao R
European journal of pharmacology 2023 Oct 15;957:176000
European journal of pharmacology 2023 Oct 15;957:176000
Colchicine protects against the development of experimental abdominal aortic aneurysm.
Zhao Y, Shen QR, Chen YX, Shi Y, Wu WB, Li Q, Li DJ, Shen FM, Fu H
Clinical science (London, England : 1979) 2023 Oct 11;137(19):1533-1545
Clinical science (London, England : 1979) 2023 Oct 11;137(19):1533-1545
20(R)-ginsenoside Rg3-loaded polyurethane/marine polysaccharide based nanofiber dressings improved burn wound healing potentials.
Guo X, Xiu F, Bera H, Abbasi YF, Chen Y, Si L, Liu P, Zhao C, Tang X, Feng Y, Cun D, Zhao X, Yang M
Carbohydrate polymers 2023 Oct 1;317:121085
Carbohydrate polymers 2023 Oct 1;317:121085
Structural analysis and attenuates hyperuricemic nephropathy of dextran from the Imperata cylindrica Beauv. var. major (Nees) C. E. Hubb.
Yu W, Xiong Y, Liu M, Zeng D, Zhao H, Liu J, Lu W
Carbohydrate polymers 2023 Oct 1;317:121064
Carbohydrate polymers 2023 Oct 1;317:121064
Mannan-binding lectin ameliorates renal fibrosis by suppressing macrophage-to-myofibroblast transition.
Xu L, Jiang H, Xie J, Xu Q, Zhou J, Lu X, Wang M, Dong L, Zuo D
Heliyon 2023 Nov;9(11):e21882
Heliyon 2023 Nov;9(11):e21882
Pacenta polypeptide injection alleviates the fibrosis and inflammation in cigarette smoke extracts-induced BEAS-2B cells by modulating MMP-9/TIMP-1 signaling.
Xu W, Li F, Zhu L, Cheng M, Cheng Y
Journal of biochemical and molecular toxicology 2023 Nov;37(11):e23453
Journal of biochemical and molecular toxicology 2023 Nov;37(11):e23453
Single-cell analysis reveals immune cellular components in odontogenic keratocysts.
Man QW, Li RF, Liu JF, Zhao Y, Liu B
Oral diseases 2023 Nov;29(8):3420-3432
Oral diseases 2023 Nov;29(8):3420-3432
Macrophage-derived inflammation promotes pulmonary vascular remodeling in hypoxia-induced pulmonary arterial hypertension mice.
Liu H, Wang Y, Zhang Q, Liu C, Ma Y, Huang P, Ge R, Ma L
Immunology letters 2023 Nov;263:113-122
Immunology letters 2023 Nov;263:113-122
Unleashing the healing potential: Exploring next-generation regenerative protein nanoscaffolds for burn wound recovery.
Si L, Guo X, Bera H, Chen Y, Xiu F, Liu P, Zhao C, Abbasi YF, Tang X, Foderà V, Cun D, Yang M
Asian journal of pharmaceutical sciences 2023 Nov;18(6):100856
Asian journal of pharmaceutical sciences 2023 Nov;18(6):100856
Butyrate alleviates renal fibrosis in CKD by regulating NLRP3-mediated pyroptosis via the STING/NF-κB/p65 pathway.
Tian X, Zeng Y, Tu Q, Jiao Y, Yao S, Chen Y, Sun L, Xia Q, Luo Y, Yuan L, Jiang Q
International immunopharmacology 2023 Nov;124(Pt B):111010
International immunopharmacology 2023 Nov;124(Pt B):111010
3D Prestress Bioprinting of Directed Tissues.
Li Y, Wu J, He C, He H, Xie M, Yao K, He J, Duan Y, Zhaung L, Wang P, He Y
Advanced healthcare materials 2023 Nov;12(28):e2301487
Advanced healthcare materials 2023 Nov;12(28):e2301487
Silk Acid as an Implantable Biomaterial for Tissue Regeneration.
Sun Z, Huang R, Lyu H, Yu X, Wang W, Li J, Lu X, Guo C
Advanced healthcare materials 2023 Nov;12(28):e2301439
Advanced healthcare materials 2023 Nov;12(28):e2301439
Caveolin-1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease.
Deng GH, Wu CF, Li YJ, Shi H, Zhong WC, Hong MK, Li JJ, Zhao JM, Liu C, Qin MC, Zeng ZY, Zhang WM, Yung KKL, Lv ZP, Gao L
Military Medical Research 2023 Nov 8;10(1):53
Military Medical Research 2023 Nov 8;10(1):53
Schisandrin B Alleviates Renal Tubular Cell Epithelial-Mesenchymal Transition and Mitochondrial Dysfunction by Kielin/Chordin-like Protein Upregulation via Akt Pathway Inactivation and Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase Pathway Activation in Diabetic Kidney Disease.
Liu W, Li F, Guo D, Du C, Zhao S, Li J, Yan Z, Hao J
Molecules (Basel, Switzerland) 2023 Nov 29;28(23)
Molecules (Basel, Switzerland) 2023 Nov 29;28(23)
Extracellular vesicle-derived silk fibroin nanoparticles loaded with MFGE8 accelerate skin ulcer healing by targeting the vascular endothelial cells.
Luo L, Zhang H, Zhang S, Luo C, Kan X, Lv J, Zhao P, Tian Z, Li C
Journal of nanobiotechnology 2023 Nov 29;21(1):455
Journal of nanobiotechnology 2023 Nov 29;21(1):455
A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis in mice via binding and relocating acetyl-coA carboxylase.
Lin Y, Yang M, Huang L, Yang F, Fan J, Qiang Y, Chang Y, Zhou W, Yan L, Xiong J, Ping J, Chen S, Men D, Li F
Cell reports 2023 Nov 28;42(11):113453
Cell reports 2023 Nov 28;42(11):113453
Netrin-1 feedforward mechanism promotes pancreatic cancer liver metastasis via hepatic stellate cell activation, retinoid, and ELF3 signaling.
Dudgeon C, Casabianca A, Harris C, Ogier C, Bellina M, Fiore S, Bernet A, Ducarouge B, Goldschneider D, Su X, Pitarresi J, Hezel A, De S, Narrow W, Soliman F, Shields C, Vendramini-Costa DB, Prela O, Wang L, Astsaturov I, Mehlen P, Carpizo DR
Cell reports 2023 Nov 28;42(11):113369
Cell reports 2023 Nov 28;42(11):113369
Precisely Regulating M2 Subtype Macrophages for Renal Fibrosis Resolution.
Luo L, Wang S, Hu Y, Wang L, Jiang X, Zhang J, Liu X, Guo X, Luo Z, Zhu C, Xie M, Li Y, You J, Yang F
ACS nano 2023 Nov 28;17(22):22508-22526
ACS nano 2023 Nov 28;17(22):22508-22526
Four-dimensional hydrogel dressing adaptable to the urethral microenvironment for scarless urethral reconstruction.
Hua Y, Wang K, Huo Y, Zhuang Y, Wang Y, Fang W, Sun Y, Zhou G, Fu Q, Cui W, Zhang K
Nature communications 2023 Nov 22;14(1):7632
Nature communications 2023 Nov 22;14(1):7632
RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment.
Kong P, Wang X, Gao YK, Zhang DD, Huang XF, Song Y, Zhang WD, Guo RJ, Li H, Han M
Biology direct 2023 Nov 20;18(1):78
Biology direct 2023 Nov 20;18(1):78
FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression.
Hu WM, Li M, Ning JZ, Tang YQ, Song TB, Li LZ, Zou F, Cheng F, Yu WM
Journal of experimental & clinical cancer research : CR 2023 Nov 2;42(1):290
Journal of experimental & clinical cancer research : CR 2023 Nov 2;42(1):290
Exosomes derived from cardiac fibroblasts with angiotensin II stimulation provoke hypertrophy and autophagy inhibition in cardiomyocytes.
Xu ST, Zhang YX, Liu SL, Liu F, Ye JT
Biochemical and biophysical research communications 2023 Nov 19;682:199-206
Biochemical and biophysical research communications 2023 Nov 19;682:199-206
MircroRNA-92b as a negative regulator of the TGF-β signaling by targeting the type I receptor.
Yang S, Jiang K, Li L, Xiang J, Li Y, Kang L, Yang G, Liang Z
iScience 2023 Nov 17;26(11):108131
iScience 2023 Nov 17;26(11):108131
A role of TRIM59 in pulmonary hypertension: modulating the protein ubiquitylation modification.
Liu Y, Zhu L, Ming Y, Wu Z, Zhang L, Chen Q, Qi Y
Journal of translational medicine 2023 Nov 17;21(1):821
Journal of translational medicine 2023 Nov 17;21(1):821
Gracillin relieves pulmonary fibrosis by suppressing the STAT3 axis.
Xie M, Yang L, Cheng J, Qu H, Gu Y, Ding C, Xu X, Zhao C, Huang X, Wang L
Journal of ethnopharmacology 2023 Nov 15;316:116704
Journal of ethnopharmacology 2023 Nov 15;316:116704
Circ_16601 facilitates Hippo pathway signaling via the miR-5580-5p/FGB axis to promote my-CAF recruitment in the TME and LUAD progression.
Zhou J, Li P, Zhao X, Zhao Y, Luo J, Deng Y, Jiang N, Xiao Z, Zhang W, Zhou Y, Zhao J, Li P, Li Y, Tian Z
Respiratory research 2023 Nov 12;24(1):276
Respiratory research 2023 Nov 12;24(1):276
Electroacupuncture alleviates intrauterine adhesion through regulating autophagy in rats.
Liu J, Zhu Q, Pan Y, Hao S, Wang Z, Cui C, Li J, Huang Y, Xia L, Xu T, Cheng J, Shen J, Xia Y
Molecular human reproduction 2023 Nov 1;29(11)
Molecular human reproduction 2023 Nov 1;29(11)
cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis.
Jiang A, Liu J, Wang Y, Zhang C
Free radical biology & medicine 2023 Nov 1;208:516-529
Free radical biology & medicine 2023 Nov 1;208:516-529
Folic acid supplementation rescues bladder injury in fetal rats with myelomeningocele.
Feng S, Yang Y, Yu Z, Bi Y
Birth defects research 2023 Nov 1;115(18):1685-1692
Birth defects research 2023 Nov 1;115(18):1685-1692
Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction.
Wang K, Li Z, Ding Y, Liu Z, Li Y, Liu X, Sun Y, Hong J, Zheng W, Qian L, Xu D
Journal of physiology and biochemistry 2023 May;79(2):341-353
Journal of physiology and biochemistry 2023 May;79(2):341-353
Dihydroartemisinin inhibits the activation and proliferation of hepatic stellate cells by regulating miR‑29b‑3p.
Huan S, Sun S, Song S, Dai J, Zhu G, Zhong Y, Ji Y, Zheng S, Yin G
International journal of molecular medicine 2023 May;51(5)
International journal of molecular medicine 2023 May;51(5)
Prolonged exposure to the herbicide atrazine promotes kidney fibrosis by activating Wnt/β-catenin signaling in rats.
Wang T, Huang X, Liu J, Liu W, Yang Z, He K, Chen J, Zhao L
Environmental toxicology 2023 May;38(5):1143-1152
Environmental toxicology 2023 May;38(5):1143-1152
Liver sinusoidal endothelial S1pr2 regulates experimental liver fibrosis through YAP/TGF-β signaling pathway.
Liao Y, Zhou C, Duan Y, Liu X, Yue J, Li X, Wu J, Wan C, Zhang L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 May;37(5):e22905
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 May;37(5):e22905
CircRNA_0017076 acts as a sponge for miR-185-5p in the control of epithelial-to-mesenchymal transition of tubular epithelial cells during renal interstitial fibrosis.
Zhang F, Zou H, Li X, Liu J, Xie Y, Chen M, Yu J, Wu X, Guo B
Human cell 2023 May;36(3):1024-1040
Human cell 2023 May;36(3):1024-1040
Lycopene inhibits endothelial-to-mesenchymal transition of choroidal vascular endothelial cells in laser-induced mouse choroidal neovascularization.
Li L, Cao X, Huang L, Huang X, Gu J, Yu X, Zhu Y, Zhou Y, Song Y, Zhu M
Journal of cellular and molecular medicine 2023 May;27(10):1327-1340
Journal of cellular and molecular medicine 2023 May;27(10):1327-1340
Ambient particulate matter exposure plus chronic ethanol ingestion exacerbates hepatic fibrosis by triggering the mitochondrial ROS-ferroptosis signaling pathway in mice.
Ding S, Jiang J, Zhang G, Yu M, Zheng Y
Ecotoxicology and environmental safety 2023 May;256:114897
Ecotoxicology and environmental safety 2023 May;256:114897
A multifunctional neuromodulation platform utilizing Schwann cell-derived exosomes orchestrates bone microenvironment via immunomodulation, angiogenesis and osteogenesis.
Hao Z, Ren L, Zhang Z, Yang Z, Wu S, Liu G, Cheng B, Wu J, Xia J
Bioactive materials 2023 May;23:206-222
Bioactive materials 2023 May;23:206-222
Inhibitory effect of miR-138-5p on choroidal fibrosis in lens-induced myopia guinea pigs via suppressing the HIF-1α signaling pathway.
Li T, Li X, Hao Y, Liu J, Bao B, Yang Z, Zhou M, Wei H, Zhang R, Hao J, Jiang W, Bi H, Guo D
Biochemical pharmacology 2023 May;211:115517
Biochemical pharmacology 2023 May;211:115517
Nintedanib prevents TGF-β2-induced epithelial-mesenchymal transition in retinal pigment epithelial cells.
Yin Y, Liu S, Pu L, Luo J, Liu H, Wu W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114543
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114543
Nr4a1 promotes renal interstitial fibrosis by regulating the p38 MAPK phosphorylation.
Tao Y, Tang C, Wei J, Shan Y, Fang X, Li Y
Molecular medicine (Cambridge, Mass.) 2023 May 9;29(1):63
Molecular medicine (Cambridge, Mass.) 2023 May 9;29(1):63
Cryptotanshinone induces apoptosis of activated hepatic stellate cells via modulating endoplasmic reticulum stress.
Hou XX, Li YW, Song JL, Zhang W, Liu R, Yuan H, Feng TT, Jiang ZY, Li WT, Zhu CL
World journal of gastroenterology 2023 May 7;29(17):2616-2627
World journal of gastroenterology 2023 May 7;29(17):2616-2627
EPAS1 prevents telomeric damage-induced senescence by enhancing transcription of TRF1, TRF2, and RAD50.
Li KQ, Liu GJ, Liu XY, Chen QF, Huang XY, Tu Q, Zhang J, Chang Q, Xie YH, Hua R, Xu DM, Liu Z, Zhao B
Zoological research 2023 May 18;44(3):636-649
Zoological research 2023 May 18;44(3):636-649
Ginsenoside Rb1 promotes the activation of PPARα pathway via inhibiting FADD to ameliorate heart failure.
Li C, Zhang X, Li J, Liang L, Zeng J, Wen M, Pan L, Lv D, Liu M, Cheng Y, Huang H
European journal of pharmacology 2023 May 15;947:175676
European journal of pharmacology 2023 May 15;947:175676
Aristolocholic acid I promotes renal tubular epithelial fibrosis by upregulating matrix metalloproteinase-9 expression via activating the C3a/C3aR axis of macrophages.
Zhang Q, Ye J, Zhang Z, Hu Y, Wang X, Jiang W, Guo X, Chen L, Cheng S, Li J, Zhang L
Toxicology letters 2023 May 15;381:27-35
Toxicology letters 2023 May 15;381:27-35
Development and validation of a radiomics model of magnetic resonance for predicting liver metastasis in resectable pancreatic ductal adenocarcinoma patients.
Huang Y, Zhou S, Luo Y, Zou J, Li Y, Chen S, Gao M, Huang K, Lian G
Radiation oncology (London, England) 2023 May 10;18(1):79
Radiation oncology (London, England) 2023 May 10;18(1):79
The p53/miR-29a-3p axis mediates the antifibrotic effect of leonurine on angiotensin II-stimulated rat cardiac fibroblasts.
Xi T, Wang R, Pi D, Ouyang J, Yang J
Experimental cell research 2023 May 1;426(1):113556
Experimental cell research 2023 May 1;426(1):113556
Noncanonical atherosclerosis as the driving force in tricuspid aortic valve associated aneurysms - A trace collection.
Doppler C, Messner B, Mimler T, Schachner B, Rezk M, Ganhör C, Wechselberger C, Müller M, Puh S, Pröll J, Arbeithuber B, Müller T, Zierer A, Bernhard D
Journal of lipid research 2023 Mar;64(3):100338
Journal of lipid research 2023 Mar;64(3):100338
Deubiquitinating enzyme USP11 promotes renal tubular cell senescence and fibrosis via inhibiting the ubiquitin degradation of TGF-β receptor II.
Ni JY, Wang X, Xie HY, Yang NH, Li JY, Sun XA, Guo HJ, Zhou L, Zhang W, Liu J, Lu LM
Acta pharmacologica Sinica 2023 Mar;44(3):584-595
Acta pharmacologica Sinica 2023 Mar;44(3):584-595
ZD6474 Attenuates Fibrosis and Inhibits Neovascularization in Human Pterygium by Suppressing AKT-mTOR Signaling Pathway.
Liu W, Lin T, Gong L
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2023 Mar;39(2):128-138
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2023 Mar;39(2):128-138
m(6)A methylation-induced NR1D1 ablation disrupts the HSC circadian clock and promotes hepatic fibrosis.
Chen L, Xia S, Wang F, Zhou Y, Wang S, Yang T, Li Y, Xu M, Zhou Y, Kong D, Zhang Z, Shao J, Xu X, Zhang F, Zheng S
Pharmacological research 2023 Mar;189:106704
Pharmacological research 2023 Mar;189:106704
CCN2/CTGF promotes liver fibrosis through crosstalk with the Slit2/Robo signaling.
Pi L, Sun C, Jn-Simon N, Basha S, Thomas H, Figueroa V, Zarrinpar A, Cao Q, Petersen B
Journal of cell communication and signaling 2023 Mar;17(1):137-150
Journal of cell communication and signaling 2023 Mar;17(1):137-150
Deletion of LCMR1 in alveolar type II cells induces lethal impairment of lung structure and function in adult mice.
Wang Y, Li C, Wu Z, Dai Y, Liu L, Chen L
Journal of thoracic disease 2023 Mar 31;15(3):1445-1459
Journal of thoracic disease 2023 Mar 31;15(3):1445-1459
Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis.
Shkhyan R, Flynn C, Lamoure E, Sarkar A, Van Handel B, Li J, York J, Banks N, Van der Horst R, Liu NQ, Lee S, Bajaj P, Vadivel K, Harn HI, Tassey J, Lozito T, Lieberman JR, Chuong CM, Hurtig MS, Evseenko D
Science translational medicine 2023 Mar 22;15(688):eabq2395
Science translational medicine 2023 Mar 22;15(688):eabq2395
Curcumol suppresses endothelial-to-mesenchymal transition via inhibiting the AKT/GSK3β signaling pathway and alleviates pulmonary arterial hypertension in rats.
Nie X, Wu Z, Shang J, Zhu L, Liu Y, Qi Y
European journal of pharmacology 2023 Mar 15;943:175546
European journal of pharmacology 2023 Mar 15;943:175546
Benzylisoquinoline alkaloids inhibit lung fibroblast activation mainly via inhibiting TGF-β1/Smads and ERK1/2 pathway proteins.
Ren HL, Zhang JH, Xiao JH
Heliyon 2023 Jun;9(6):e16849
Heliyon 2023 Jun;9(6):e16849
FAM3A mediates the phenotypic switch of human aortic smooth muscle cells stimulated with oxidised low-density lipoprotein by influencing the PI3K-AKT pathway.
Yang L, Du B, Zhang S, Wang M
In vitro cellular & developmental biology. Animal 2023 Jun;59(6):431-442
In vitro cellular & developmental biology. Animal 2023 Jun;59(6):431-442
Collagen Triple Helix Repeat Containing 1 Deficiency Protects Against Airway Remodeling and Inflammation in Asthma Models In Vivo and In Vitro.
Feng Y, Hu J, Liu F, Shang Y
Inflammation 2023 Jun;46(3):925-940
Inflammation 2023 Jun;46(3):925-940
Efficacy of Danggui Buxue decoction on diabetic nephropathy-induced renal fibrosis in rats and possible mechanism.
Ye Z, Xian W, Ling GU, Zihang LI, Jingtian Z, Wenkai W, Liang Z, Mei X
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Jun;43(3):507-513
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Jun;43(3):507-513
A novel tetra-PEG based hydrogel for prevention of esophageal stricture after ESD in a porcine model.
Wei Y, Tang J, Li J, Hou X, Li L, Zhang D, Chai D, Zhao M, Liu F
Colloids and surfaces. B, Biointerfaces 2023 Jun;226:113321
Colloids and surfaces. B, Biointerfaces 2023 Jun;226:113321
Protective effects of methylprednisolone-cyclophosphamide treatment on bleomycin-induced pulmonary fibrosis.
Xu Q, Zhu W, Tang M, Zhang M, Liu Y, Li Z, Rao Z, He X, Ma R, Xue X
Cytokine 2023 Jun;166:156188
Cytokine 2023 Jun;166:156188
Oroxylin A activates ferritinophagy to induce hepatic stellate cell senescence against hepatic fibrosis by regulating cGAS-STING pathway.
Sun Y, Weng J, Chen X, Ma S, Zhang Y, Zhang F, Zhang Z, Wang F, Shao J, Zheng S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jun;162:114653
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jun;162:114653
Inflachromene inhibits intimal hyperplasia through the HMGB1/2- regulated TLR4-NF-κB pathway.
Teng S, Zhu Z, Wu C, He Y, Zhou S
International immunopharmacology 2023 Jun;119:110198
International immunopharmacology 2023 Jun;119:110198
Differences in p38-STAT3-S100A11 signaling after the administration of aristolochic acid I and IVa may account for the disparity in their nephrotoxicity.
Xian Z, Tian J, Zhao Y, Yi Y, Li C, Han J, Zhang Y, Wang Y, Wang L, Liu S, Pan C, Liu C, Wang D, Meng J, Tang X, Wang F, Liang A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154815
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154815
Aloe-emodin ameliorated MI-induced cardiac remodeling in mice via inhibiting TGF-β/SMAD signaling via up-regulating SMAD7.
Yu J, Zhao X, Yan X, Li W, Liu Y, Wang J, Wang J, Yang Y, Hao Y, Liang Z, Tao Y, Yuan Y, Du Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154793
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154793
Silencing of NOTCH3 Signaling in Meniscus Smooth Muscle Cells Inhibits Fibrosis and Exacerbates Degeneration in a HEYL-Dependent Manner.
Sun H, Liu F, Lin Z, Jiang Z, Wen X, Xu J, Zhang Z, Ma R
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(16):e2207020
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jun;10(16):e2207020
Time-dependent effect of REV-ERBα agonist SR9009 on nonalcoholic steatohepatitis and gut microbiota in mice.
Ni Y, Nan S, Zheng L, Zhang L, Zhao Y, Fu Z
Chronobiology international 2023 Jun 3;40(6):769-782
Chronobiology international 2023 Jun 3;40(6):769-782
MgIG Attenuates Oxaliplatin-induced Hepatotoxicity through Suppression of Connexin 43 in Hepatic Stellate Cells.
Cao Y, Xia Y, Wang Y, Shi H, Wu Y, Lu Y
Journal of clinical and translational hepatology 2023 Jun 28;11(3):584-594
Journal of clinical and translational hepatology 2023 Jun 28;11(3):584-594
Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration.
Sun L, Zhang X, Wu S, Liu Y, Guerrero-Juarez CF, Liu W, Huang J, Yao Q, Yin M, Li J, Ramos R, Liao Y, Wu R, Xia T, Zhang X, Yang Y, Li F, Heng S, Zhang W, Yang M, Tzeng CM, Ji C, Plikus MV, Gallo RL, Zhang LJ
Cell reports 2023 Jun 27;42(6):112647
Cell reports 2023 Jun 27;42(6):112647
Identification of potential biomarkers for idiopathic pulmonary fibrosis and validation of TDO2 as a potential therapeutic target.
Wang R, Yang YM
World journal of cardiology 2023 Jun 26;15(6):293-308
World journal of cardiology 2023 Jun 26;15(6):293-308
Autophagy-Interfering Nanoboat Drifting along CD44-Golgi-ER Flow as RNAi Therapeutics for Hepatic Fibrosis.
Wang Y, Xiong L, Dong Z, Ran K, Bai W, Mo Z, Huang K, Ye Y, Tao Y, Yin S, Li M, He Q
ACS applied materials & interfaces 2023 Jun 21;15(24):28941-28953
ACS applied materials & interfaces 2023 Jun 21;15(24):28941-28953
Macrophage Dectin-1 mediates Ang II renal injury through neutrophil migration and TGF-β1 secretion.
Ye S, Huang H, Xiao Y, Han X, Shi F, Luo W, Chen J, Ye Y, Zhao X, Huang W, Wang Y, Lai D, Liang G, Fu G
Cellular and molecular life sciences : CMLS 2023 Jun 20;80(7):184
Cellular and molecular life sciences : CMLS 2023 Jun 20;80(7):184
ANO1 Reprograms Cholesterol Metabolism and the Tumor Microenvironment to Promote Cancer Metastasis.
Deng CM, Zhang GG, Liu QW, Xu JJ, Liu ZC, Yang J, Xu TY, Li ZG, Zhang F, Li B
Cancer research 2023 Jun 2;83(11):1851-1865
Cancer research 2023 Jun 2;83(11):1851-1865
HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo.
Zhang Q, Chen Y, Wang Q, Wang Y, Feng W, Chai L, Liu J, Li D, Chen H, Qiu Y, Shen N, Shi X, Xie X, Li M
Respiratory research 2023 Jun 2;24(1):149
Respiratory research 2023 Jun 2;24(1):149
Genetic lineage tracing reveals stellate cells as contributors to myofibroblasts in pancreas and islet fibrosis.
Wang J, Li T, Zhou Y, Wang X, Carvalho V, Ni C, Li W, Wang Q, Chen Y, Shang Z, Qiu S, Sun Z
iScience 2023 Jun 16;26(6):106988
iScience 2023 Jun 16;26(6):106988
Scarless wound healing programmed by core-shell microneedles.
Zhang Y, Wang S, Yang Y, Zhao S, You J, Wang J, Cai J, Wang H, Wang J, Zhang W, Yu J, Han C, Zhang Y, Gu Z
Nature communications 2023 Jun 10;14(1):3431
Nature communications 2023 Jun 10;14(1):3431
Ferroptosis in the Lacrimal Gland Is Involved in Dry Eye Syndrome Induced by Corneal Nerve Severing.
Liu X, Cui Z, Chen X, Li Y, Qiu J, Huang Y, Wang X, Chen S, Luo Q, Chen P, Zhuang J, Yu K
Investigative ophthalmology & visual science 2023 Jun 1;64(7):27
Investigative ophthalmology & visual science 2023 Jun 1;64(7):27
Venoarterial extracorporeal membrane oxygenation improves survival in a rat model of acute myocardial infarction.
Wei S, Cheng X, Li J, Zhai K, Huang J, Wang S, Li Y, Liu D
Artificial organs 2023 Jul;47(7):1163-1173
Artificial organs 2023 Jul;47(7):1163-1173
Ginseng saponin metabolite 20(S)-protopanaxadiol relieves pulmonary fibrosis by multiple-targets signaling pathways.
Ren G, Lv W, Ding Y, Wang L, Cui Z, Li R, Tian J, Zhang C
Journal of ginseng research 2023 Jul;47(4):543-551
Journal of ginseng research 2023 Jul;47(4):543-551
Total flavonoid extract from Dracocephalum moldavica L. improves pulmonary fibrosis by reducing inflammation and inhibiting the hedgehog signaling pathway.
He CH, Lv JM, Khan GJ, Duan H, Wang W, Zhai KF, Zou GA, Aisa HA
Phytotherapy research : PTR 2023 Jul;37(7):2745-2758
Phytotherapy research : PTR 2023 Jul;37(7):2745-2758
Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity.
Lu Y, Tang K, Wang S, Tian Z, Fan Y, Li B, Wang M, Zhao J, Xie J
Translational research : the journal of laboratory and clinical medicine 2023 Jul;257:54-65
Translational research : the journal of laboratory and clinical medicine 2023 Jul;257:54-65
Step-wise CAG@PLys@PDA-Cu(2+) modification on micropatterned nanofibers for programmed endothelial healing.
Yi B, Zhou B, Song Z, Yu L, Wang W, Liu W
Bioactive materials 2023 Jul;25:657-676
Bioactive materials 2023 Jul;25:657-676
Inhibiting Heat Shock Protein 90 Attenuates Nucleus Pulposus Fibrosis and Pathologic Angiogenesis Induced by Macrophages via Down-Regulating Cell Migration-Inducing Protein.
Zhang S, Wang P, Hu B, Lv X, Liu W, Chen S, Shao Z
The American journal of pathology 2023 Jul;193(7):960-976
The American journal of pathology 2023 Jul;193(7):960-976
Inhaled Lipid Nanoparticles Alleviate Established Pulmonary Fibrosis.
Li D, Zhao A, Zhu J, Wang C, Shen J, Zheng Z, Pan F, Liu Z, Chen Q, Yang Y
Small (Weinheim an der Bergstrasse, Germany) 2023 Jul;19(30):e2300545
Small (Weinheim an der Bergstrasse, Germany) 2023 Jul;19(30):e2300545
Fibroblast growth factor 10 delays the progression of osteoarthritis by attenuating synovial fibrosis via inhibition of IL-6/JAK2/STAT3 signaling in vivo and in vitro.
Su W, Zheng X, Zhou H, Yang S, Zhu X
Molecular immunology 2023 Jul;159:46-57
Molecular immunology 2023 Jul;159:46-57
Ginkgo biloba extract attenuates cisplatin-induced renal interstitial fibrosis by inhibiting the activation of renal fibroblasts through down-regulating the HIF-1α/STAT3/IL-6 pathway in renal tubular epithelial cells.
Zhang Y, Qin X, Yang Y, Li J, Li X, Zou X, Huang Z, Huang S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154809
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154809
CAFs targeted ultrasound-responsive nanodroplets loaded V9302 and GLULsiRNA to inhibit melanoma growth via glutamine metabolic reprogramming and tumor microenvironment remodeling.
Ai C, Sun X, Xiao S, Guo L, Shang M, Shi D, Meng D, Zhao Y, Wang X, Li J
Journal of nanobiotechnology 2023 Jul 8;21(1):214
Journal of nanobiotechnology 2023 Jul 8;21(1):214
Anticoagulants Enhance Molecular and Cellular Immunotherapy of Cancer by Improving Tumor Microcirculation Structure and Function and Redistributing Tumor Infiltrates.
Wei F, Su Y, Quan Y, Li X, Zou Q, Zhang L, Li S, Jiang M, Lin G, Liang P, He J, Xie K
Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Jul 5;29(13):2525-2539
Clinical cancer research : an official journal of the American Association for Cancer Research 2023 Jul 5;29(13):2525-2539
Metformin attenuates chronic lung allograft dysfunction: evidence in rat models.
Tian D, Zheng X, Tang H, Huang H, Wang J, Xu L, Li C, Yan H, Yu R, Nan J, Liu M, Guo X, Jian S, Wang T, Deng S, Pu Q, Liu L
Respiratory research 2023 Jul 29;24(1):192
Respiratory research 2023 Jul 29;24(1):192
Disruption of RCAN1.4 expression mediated by YY1/HDAC2 modulates chronic renal allograft interstitial fibrosis.
Zhang J, Zhang Y, Feng D, Zhou H, Gui Z, Zheng M, Hang Z, Gu M, Tan R
Cell death discovery 2023 Jul 28;9(1):271
Cell death discovery 2023 Jul 28;9(1):271
Identification of TGF-β-related genes in cardiac hypertrophy and heart failure based on single cell RNA sequencing.
Huang K, Wu H, Xu X, Wu L, Li Q, Han L
Aging 2023 Jul 26;15(14):7187-7218
Aging 2023 Jul 26;15(14):7187-7218
Achieving tissue-level softness on stretchable electronics through a generalizable soft interlayer design.
Li Y, Li N, Liu W, Prominski A, Kang S, Dai Y, Liu Y, Hu H, Wai S, Dai S, Cheng Z, Su Q, Cheng P, Wei C, Jin L, Hubbell JA, Tian B, Wang S
Nature communications 2023 Jul 26;14(1):4488
Nature communications 2023 Jul 26;14(1):4488
CXCL17 Attenuates Diesel Exhaust Emissions Exposure-Induced Lung Damage by Regulating Macrophage Function.
Yin Y, Mu C, Wang J, Wang Y, Hu W, Zhu W, Yu X, Hao W, Zheng Y, Li Q, Han W
Toxics 2023 Jul 26;11(8)
Toxics 2023 Jul 26;11(8)
Metformin suppressed tendon injury-induced adhesion via hydrogel-nanoparticle sustained-release system.
Jie Li Z, Bing Luo C, Liang Wang H, Sun J, Qian Yang Q, Lang Zhou Y
International journal of pharmaceutics 2023 Jul 25;642:123190
International journal of pharmaceutics 2023 Jul 25;642:123190
Wen-Shen-Jian-Pi-Hua-Tan decoction protects against early obesity-related glomerulopathy by improving renal bile acid composition and suppressing lipogenesis, inflammation, and fibrosis.
Song D, Zhang A, Hu X, Zeng M, Zhou H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154861
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154861
Nanoengineered mesenchymal stem cell therapy for pulmonary fibrosis in young and aged mice.
Han MM, He XY, Tang L, Qi L, Yang MY, Wang Y, Xing L, Jeong JH, Jiang HL
Science advances 2023 Jul 21;9(29):eadg5358
Science advances 2023 Jul 21;9(29):eadg5358
Atractylenolide III Ameliorates Bile Duct Ligation-Induced Liver Fibrosis by Inhibiting the PI3K/AKT Pathway and Regulating Glutamine Metabolism.
Wang Y, Shi K, Tu J, Ke C, Chen N, Wang B, Liu Y, Zhou Z
Molecules (Basel, Switzerland) 2023 Jul 19;28(14)
Molecules (Basel, Switzerland) 2023 Jul 19;28(14)
Single-cell transcriptome sequencing-based analysis: probing the mechanisms of glycoprotein NMB regulation of epithelial cells involved in silicosis.
Yang S, Sun Y, Long M, Zhou X, Yuan M, Yang L, Luo W, Cheng Y, Zhang X, Jiang W, Chao J
Particle and fibre toxicology 2023 Jul 19;20(1):29
Particle and fibre toxicology 2023 Jul 19;20(1):29
Elevated retinal fibrosis in experimental myopia is involved in the activation of the PI3K/AKT/ERK signaling pathway.
Bao B, Liu J, Li T, Yang Z, Wang G, Xin J, Bi H, Guo D
Archives of biochemistry and biophysics 2023 Jul 15;743:109663
Archives of biochemistry and biophysics 2023 Jul 15;743:109663
Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer.
Zhang Y, Fan A, Li Y, Liu Z, Yu L, Guo J, Hou J, Li X, Chen W
Cancer letters 2023 Jul 10;566:216244
Cancer letters 2023 Jul 10;566:216244
Ginsenoside Rg3 liposomes regulate tumor microenvironment for the treatment of triple negative breast cancer.
Miao L, Ma H, Dong T, Zhao C, Gao T, Wu T, Xu H, Zhang J
Drug development and industrial pharmacy 2023 Jan;49(1):139-148
Drug development and industrial pharmacy 2023 Jan;49(1):139-148
Imbalance in ALR ubiquitination accelerates the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma.
Zheng M, Ai Z, Guo Y, Chen Y, Xie P, An W
Oncogene 2023 Jan;42(4):308-321
Oncogene 2023 Jan;42(4):308-321
Quercetin inhibits the amphiregulin/EGFR signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in obstructive nephropathy.
Wang Q, Wang F, Li X, Ma Z, Jiang D
Phytotherapy research : PTR 2023 Jan;37(1):111-123
Phytotherapy research : PTR 2023 Jan;37(1):111-123
Single-cell RNA sequencing analysis revealed cellular and molecular immune profiles in lung squamous cell carcinoma.
Hao B, Zhang Z, Lu Z, Xiong J, Fan T, Song C, He R, Zhang L, Pan S, Li D, Meng H, Lin W, Luo B, Yang J, Li N, Geng Q
Translational oncology 2023 Jan;27:101568
Translational oncology 2023 Jan;27:101568
Spinal Cord Stimulation Attenuates Neural Remodeling, Inflammation, and Fibrosis After Myocardial Infarction.
He Y, Sun Z, Jiang J, Yin X, Han J, Zhang Y, Zheng L
Neuromodulation : journal of the International Neuromodulation Society 2023 Jan;26(1):57-67
Neuromodulation : journal of the International Neuromodulation Society 2023 Jan;26(1):57-67
Qing Fei Hua Xian Decoction ameliorates bleomycin-induced pulmonary fibrosis by suppressing oxidative stress through balancing ACE-AngII-AT1R/ACE2-Ang-(1-7)-Mas axis.
Li RJ, Wu CY, Ke HL, Wang XP, Zhang YW
Iranian journal of basic medical sciences 2023 Jan;26(1):107-113
Iranian journal of basic medical sciences 2023 Jan;26(1):107-113
PD-L1 upregulation promotes drug-induced pulmonary fibrosis by inhibiting vimentin degradation.
Li Q, Deng MS, Wang RT, Luo H, Luo YY, Zhang DD, Chen KJ, Cao XF, Yang GM, Zhao TM, Xu B, Xu CX, Wang JM
Pharmacological research 2023 Jan;187:106636
Pharmacological research 2023 Jan;187:106636
Oroxylin A regulates cGAS DNA hypermethylation induced by methionine metabolism to promote HSC senescence.
Zhao D, Gao Y, Su Y, Zhou Y, Yang T, Li Y, Wang Y, Sun Y, Chen L, Zhang F, Zhang Z, Wang F, Shao J, Zheng S
Pharmacological research 2023 Jan;187:106590
Pharmacological research 2023 Jan;187:106590
The effects of taraxasterol on liver fibrosis revealed by RNA sequencing.
He H, Xu B, Ge P, Gao Y, Wei M, Li T, Zhang R, Li B, Cao H, Zhang K
International immunopharmacology 2023 Jan;114:109481
International immunopharmacology 2023 Jan;114:109481
Effective-compounds of Jinshui Huanxian formula ameliorates fibroblast activation in pulmonary fibrosis by inhibiting the activation of mTOR signaling.
Li J, Li K, Tian Y, Zhao P, Liu X, Li M, Bai Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154604
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154604
Yishen-Qingli-Huoxue formula attenuates renal fibrosis by inhibiting indoxyl sulfate via AhR/snai1 signaling.
Chen C, Sun S, Zhao J, Wu Q, He W, Sun W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154546
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154546
Elevated Angiotensin-II Levels Contribute to the Pathogenesis of Open-Angle Glaucoma Via Inducing the Expression of Fibrosis-Related Genes in Trabecular Meshwork Cells Through a ROS/NOX4/SMAD3 Axis.
Li H, Cui H, Ren J, Wang D, Zhao R, Zhu S, Liu S, Liu X, Tian S, Zhang Y, Zhao P, Li P, Thorne RF, Duan S
Cell transplantation 2023 Jan-Dec;32:9636897231162526
Cell transplantation 2023 Jan-Dec;32:9636897231162526
N-acetylglucosamine-bearing polymers mimicking O-GlcNAc-modified proteins elicit anti-fibrotic activities in myofibroblasts and activated stellate cells.
Ise H, Araki Y, Song I, Akatsuka G
Glycobiology 2023 Jan 8;33(1):17-37
Glycobiology 2023 Jan 8;33(1):17-37
Neuron-Glial Antigen 2 Participates in Liver Fibrosis via Regulating the Differentiation of Bone Marrow Mesenchymal Stem Cell to Myofibroblast.
Yang L, Zhang H, Dong C, Yue W, Xue R, Liu F, Yang L, Li L
International journal of molecular sciences 2023 Jan 7;24(2)
International journal of molecular sciences 2023 Jan 7;24(2)
Cryptotanshinone modulates proliferation, apoptosis, and fibrosis through inhibiting AR and EGFR/STAT3 axis to ameliorate benign prostatic hyperplasia progression.
Wei P, Lin D, Zhang M, Luo C, Wu X, Deng B, Cui K, Chen Z
European journal of pharmacology 2023 Jan 5;938:175434
European journal of pharmacology 2023 Jan 5;938:175434
Baicalin prevents fibrosis of human trabecular meshwork cells via inhibiting the MyD88/NF-κB pathway.
Li L, Liu Q, Shi L, Zhou X, Wu W, Wang X, Wang L, Wu Z
European journal of pharmacology 2023 Jan 5;938:175425
European journal of pharmacology 2023 Jan 5;938:175425
Facile preparation of a novel nanoemulsion based hyaluronic acid hydrogel loading with Poria cocos triterpenoids extract for wound dressing.
Ding X, Li S, Tian M, Yang P, Ding Y, Wang Y, Duan G, Zhang D, Chen B, Tan Q
International journal of biological macromolecules 2023 Jan 31;226:1490-1499
International journal of biological macromolecules 2023 Jan 31;226:1490-1499
Increased β1-adrenergic receptor antibody confers a vulnerable substrate for atrial fibrillation via mediating Ca2+ mishandling and atrial fibrosis in active immunization rabbit models.
Sun H, Song J, Li K, Li Y, Shang L, Zhou Q, Lu Y, Zong Y, He X, Kari M, Yang H, Zhou X, Zhang L, Tang B
Clinical science (London, England : 1979) 2023 Jan 31;137(2):195-217
Clinical science (London, England : 1979) 2023 Jan 31;137(2):195-217
Biejiajian pill inhibits progression of hepatocellular carcinoma by downregulating PDGFRβ signaling in cancer-associated fibroblasts.
Chen W, Yang X, Sun J, Chen Y, Zhao W, He C, An H, Pang J, Xu W, Wen B, Sun H, He S
Journal of ethnopharmacology 2023 Jan 30;301:115825
Journal of ethnopharmacology 2023 Jan 30;301:115825
Exosomes derived from human adipose mesenchymal stem cells ameliorate hepatic fibrosis by inhibiting PI3K/Akt/mTOR pathway and remodeling choline metabolism.
Zhang Z, Shang J, Yang Q, Dai Z, Liang Y, Lai C, Feng T, Zhong D, Zou H, Sun L, Su Y, Yan S, Chen J, Yao Y, Shi Y, Huang X
Journal of nanobiotechnology 2023 Jan 25;21(1):29
Journal of nanobiotechnology 2023 Jan 25;21(1):29
PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation.
Peng Z, Tan X, Xie L, Li Z, Zhou S, Li Y
iScience 2023 Jan 20;26(1):105909
iScience 2023 Jan 20;26(1):105909
Orally administration of cerium oxide nanozyme for computed tomography imaging and anti-inflammatory/anti-fibrotic therapy of inflammatory bowel disease.
Cao Y, Cheng K, Yang M, Deng Z, Ma Y, Yan X, Zhang Y, Jia Z, Wang J, Tu K, Liang J, Zhang M
Journal of nanobiotechnology 2023 Jan 19;21(1):21
Journal of nanobiotechnology 2023 Jan 19;21(1):21
HDAC7/c-Myc signaling pathway promotes the proliferation and metastasis of choroidal melanoma cells.
Zhang Y, Ding P, Wang Y, Shao C, Guo K, Yang H, Feng Y, Ning J, Pan M, Wang P, Yan X, Ma Z, Han J
Cell death & disease 2023 Jan 18;14(1):38
Cell death & disease 2023 Jan 18;14(1):38
Endosulfan induced kidney cell injury by modulating ACE2 through up-regulating miR-429 in HK-2 cells.
Zhang B, Liu S, Sun Y, Xu D
Toxicology 2023 Jan 15;484:153392
Toxicology 2023 Jan 15;484:153392
20-Hydroxytetraenoic acid induces hepatic fibrosis via the TGF-β1/Smad3 signaling pathway.
Li B, Ma Y, Tan L, Ren H, Wu L, Su Q, Song J, Chen W, Gong P, Jin Y
Toxicology letters 2023 Jan 15;373:1-12
Toxicology letters 2023 Jan 15;373:1-12
The m6A demethylase FTO promotes keloid formation by up-regulating COL1A1.
Ren S, Ji Y, Wang M, Ye M, Huang L, Cai X
Annals of translational medicine 2023 Jan 15;11(1):15
Annals of translational medicine 2023 Jan 15;11(1):15
Cell-Permeable PROTAC Degraders against KEAP1 Efficiently Suppress Hepatic Stellate Cell Activation through the Antioxidant and Anti-Inflammatory Pathway.
Wang F, Zhan Y, Li M, Wang L, Zheng A, Liu C, Wang H, Wang T
ACS pharmacology & translational science 2023 Jan 13;6(1):76-87
ACS pharmacology & translational science 2023 Jan 13;6(1):76-87
Endoscopy Deliverable and Mushroom-Cap-Inspired Hyperboloid-Shaped Drug-Laden Bioadhesive Hydrogel for Stomach Perforation Repair.
Liu S, Luan Z, Wang T, Xu K, Luo Q, Ye S, Wang W, Dan R, Shu Z, Huang Y, Mequanint K, Fan C, Xing M, Yang S
ACS nano 2023 Jan 10;17(1):111-126
ACS nano 2023 Jan 10;17(1):111-126
Macrophage-derived exosomal lncRNA MSTRG.91634.7 inhibits fibroblasts activation by targeting PINK1 in silica-induced lung fibrosis.
Ban J, Liu F, Zhang Q, Chang S, Zeng X, Chen J
Toxicology letters 2023 Jan 1;372:36-44
Toxicology letters 2023 Jan 1;372:36-44
VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice.
Tao H, Zhao H, Mo A, Shao L, Ge D, Liu J, Hu W, Xu K, Ma Q, Wang W, Wang W, Cao H, Mu M, Tao X, Wang J
Ecotoxicology and environmental safety 2023 Jan 1;249:114359
Ecotoxicology and environmental safety 2023 Jan 1;249:114359
Type 1 diabetes mellitus leads to gingivitis and an early compensatory increase in bone remodeling.
Yuan X, Amin V, Zhu T, Kittaka M, Ueki Y, Bellido TM, Turkkahraman H
Journal of periodontology 2023 Feb;94(2):277-289
Journal of periodontology 2023 Feb;94(2):277-289
Generation of an induced pluripotent stem cell line (IPCASi001-A) from an autism spectrum disorder individual without intellectual disability.
Yang L, Lu S, Yang Z, Yao J, Zhou P, Zhao M
Stem cell research 2023 Feb;66:102994
Stem cell research 2023 Feb;66:102994
Deposition of platelet-derived microparticles in podocytes contributes to diabetic nephropathy.
Huang SJ, Zhang Y, Wang GH, Lu J, Chen PP, Zhang JX, Li XQ, Yuan BY, Liu XQ, Jiang TT, Wang MY, Liu WT, Ruan XZ, Liu BC, Ma KL
International urology and nephrology 2023 Feb;55(2):355-366
International urology and nephrology 2023 Feb;55(2):355-366
Glycyrrhizic acid improves tacrolimus-induced renal injury by regulating autophagy.
Cao R, Li Y, Hu X, Qiu Y, Li S, Xie Y, Xu C, Lu C, Chen G, Yang J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22749
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22749
In Situ Endothelialization of Free-Form 3D Network of Interconnected Tubular Channels via Interfacial Coacervation by Aqueous-in-Aqueous Embedded Bioprinting.
Zhang S, Qi C, Zhang W, Zhou H, Wu N, Yang M, Meng S, Liu Z, Kong T
Advanced materials (Deerfield Beach, Fla.) 2023 Feb;35(7):e2209263
Advanced materials (Deerfield Beach, Fla.) 2023 Feb;35(7):e2209263
miRNA‑92a inhibits vascular smooth muscle cell phenotypic modulation and may help prevent in‑stent restenosis.
Jiang F, Zhang B, Zhang X, Zhang R, Lu Q, Shi F, Xu J, Deng L
Molecular medicine reports 2023 Feb;27(2)
Molecular medicine reports 2023 Feb;27(2)
Effects of substrate topography on the regulation of human fibroblasts and capsule formation via modulating macrophage polarization.
Chen C, Chen Y, Lan YJ, Tian MN, Zhang YM, Lei ZY, Fan DL
Colloids and surfaces. B, Biointerfaces 2023 Feb;222:113086
Colloids and surfaces. B, Biointerfaces 2023 Feb;222:113086
Fc Fragment of IgE Receptor Ig (FCER1G) acts as a key gene involved in cancer immune infiltration and tumour microenvironment.
Yang R, Chen Z, Liang L, Ao S, Zhang J, Chang Z, Wang Z, Zhou Y, Duan X, Deng T
Immunology 2023 Feb;168(2):302-319
Immunology 2023 Feb;168(2):302-319
A small-molecule JNK inhibitor JM-2 attenuates high-fat diet-induced non-alcoholic fatty liver disease in mice.
Jin L, Wang M, Yang B, Ye L, Zhu W, Zhang Q, Lou S, Zhang Y, Luo W, Liang G
International immunopharmacology 2023 Feb;115:109587
International immunopharmacology 2023 Feb;115:109587
Hepatic stellate cell-released CXCL1 aggravates HCC malignant behaviors through the MIR4435-2HG/miR-506-3p/TGFB1 axis.
Li S, Hu X, Yu S, Yi P, Chen R, Huang Z, Huang Y, Huang Y, Zhou R, Fan X
Cancer science 2023 Feb;114(2):504-520
Cancer science 2023 Feb;114(2):504-520
Loss of Protein Kinase D2 Activity Protects Against Bleomycin-Induced Dermal Fibrosis in Mice.
Chen L, Zhao J, Chao Y, Roy A, Guo W, Qian J, Xu W, Domsic RT, Lafyatis R, Lu B, Deng F, Wang QJ
Laboratory investigation; a journal of technical methods and pathology 2023 Feb;103(2):100018
Laboratory investigation; a journal of technical methods and pathology 2023 Feb;103(2):100018
LIM and Cysteine-Rich Domains 1 Promotes Transforming Growth Factor β1-Induced Epithelial-Mesenchymal Transition in Human Kidney 2 Cells.
Yu R, Wu Y, He P, Bai Y, Zhang Y, Bian X, Sun G, Zhang B
Laboratory investigation; a journal of technical methods and pathology 2023 Feb;103(2):100016
Laboratory investigation; a journal of technical methods and pathology 2023 Feb;103(2):100016
Prognostic Value of CXCL12 in Non-Small Cell Lung Cancer Patients Undergoing Tumor Resection.
Kogue Y, Kobayashi H, Nakamura Y, Takano T, Furuta C, Kawano O, Yasuma T, Nishimura T, D'Alessandro-Gabazza CN, Fujimoto H, Gabazza EC, Kobayashi T, Fukai I
Pharmaceuticals (Basel, Switzerland) 2023 Feb 7;16(2)
Pharmaceuticals (Basel, Switzerland) 2023 Feb 7;16(2)
Secretome of hESC-Derived MSC-like Immune and Matrix Regulatory Cells Mitigate Pulmonary Fibrosis through Antioxidant and Anti-Inflammatory Effects.
Hu W, Yang J, Xue J, Ma J, Wu S, Wang J, Xu R, Wei J, Wang Y, Wang S, Liu X
Biomedicines 2023 Feb 5;11(2)
Biomedicines 2023 Feb 5;11(2)
BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma.
Chen SJ, Huang Y, Yu F, Feng X, Zheng YY, Li Q, Niu Q, Jiang YH, Zhao LQ, Wang M, Cheng PP, Song LJ, Liang LM, He XL, Xiong L, Xiang F, Wang X, Ma WL, Ye H
Cell communication and signaling : CCS 2023 Feb 20;21(1):39
Cell communication and signaling : CCS 2023 Feb 20;21(1):39
Macrophage-derived GPNMB trapped by fibrotic extracellular matrix promotes pulmonary fibrosis.
Wang J, Zhang X, Long M, Yuan M, Yin J, Luo W, Wang S, Cai Y, Jiang W, Chao J
Communications biology 2023 Feb 2;6(1):136
Communications biology 2023 Feb 2;6(1):136
Aerobic exercise inhibits renal EMT by promoting irisin expression in SHR.
Luo M, Luo S, Xue Y, Chang Q, Yang H, Dong W, Zhang T, Cao S
iScience 2023 Feb 17;26(2):105990
iScience 2023 Feb 17;26(2):105990
Nanodrug rescues liver fibrosis via synergistic therapy with H(2)O(2) depletion and Saikosaponin b1 sustained release.
Dong H, Han X, Hao M, Yang Q, Lyu Q, Tang D, Shen Z, Wang K, Kuang H, Cao G, Peng M, Shao M
Communications biology 2023 Feb 16;6(1):184
Communications biology 2023 Feb 16;6(1):184
Intermedin 1-53 Ameliorates Atrial Fibrosis and Reduces Inducibility of Atrial Fibrillation via TGF-β1/pSmad3 and Nox4 Pathway in a Rat Model of Heart Failure.
Ma S, Yan F, Hou Y
Journal of clinical medicine 2023 Feb 15;12(4)
Journal of clinical medicine 2023 Feb 15;12(4)
Gut microbiota and bile acids partially mediate the improvement of fibroblast growth factor 21 on methionine-choline-deficient diet-induced non-alcoholic fatty liver disease mice.
Lin D, Sun Q, Liu Z, Pan J, Zhu J, Wang S, Jia S, Zheng M, Li X, Gong F
Free radical biology & medicine 2023 Feb 1;195:199-218
Free radical biology & medicine 2023 Feb 1;195:199-218
Baicalin attenuates pulmonary vascular remodeling by inhibiting calpain-1 mediated endothelial-to-mesenchymal transition.
Jiang HX, Wang XD, Wang HX, Liu T
Heliyon 2023 Dec;9(12):e23076
Heliyon 2023 Dec;9(12):e23076
Estrogen inhibits the differentiation of fibroblasts induced by high stiffness matrix by enhancing DNMT1 expression.
Zhao Z, Huang G, He Y, Zuo X, Han W, Li H
Tissue & cell 2023 Dec;85:102207
Tissue & cell 2023 Dec;85:102207
RGS1 mediates renal interstitial fibrosis through activation of the inflammatory response.
Lu T, Chen S, Xu J
Archives of biochemistry and biophysics 2023 Dec;750:109744
Archives of biochemistry and biophysics 2023 Dec;750:109744
STAT6 promoting oxalate crystal deposition-induced renal fibrosis by mediating macrophage-to-myofibroblast transition via inhibiting fatty acid oxidation.
Yuan T, Xia Y, Pan S, Li B, Ye Z, Yan X, Hu W, Li L, Song B, Yu W, Li H, Rao T, Lin F, Zhou X, Cheng F
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Dec;72(12):2111-2126
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Dec;72(12):2111-2126
Evaluation of topical methylene blue nanoemulsion for wound healing in diabetic mice.
Gao Y, Jiang Z, Xu B, Mo R, Li S, Jiang Y, Zhao D, Cao W, Chen B, Tian M, Tan Q
Pharmaceutical biology 2023 Dec;61(1):1462-1473
Pharmaceutical biology 2023 Dec;61(1):1462-1473
Loke zupa decoction attenuates bronchial EMT-mediated airway remodelling in chronic asthma through the PI3K-Akt/HIF-1α signaling pathway.
Liu J, Li L, Han X, Chen Y, Diao J
Pharmaceutical biology 2023 Dec;61(1):1332-1342
Pharmaceutical biology 2023 Dec;61(1):1332-1342
Integrating network pharmacology and experimental validation to decipher the mechanism of the Chinese herbal prescription modified Shen-Yan-Fang-Shuai formula in treating diabetic nephropathy.
Yu B, Zhou M, Dong Z, Zheng H, Zhao Y, Zhou J, Zhang C, Wei F, Yu G, Liu WJ, Liu H, Wang Y
Pharmaceutical biology 2023 Dec;61(1):1222-1233
Pharmaceutical biology 2023 Dec;61(1):1222-1233
Increased m6A-RNA methylation and demethylase FTO suppression is associated with silica-induced pulmonary inflammation and fibrosis.
Xu Y, Wang L, Qian R, Zhao M, Chen X, Sun D, Wang Y, Cheng W, Chen Y, He Q, Dai Y, Yao Y
Toxicology 2023 Dec;500:153673
Toxicology 2023 Dec;500:153673
KPNA2 Silencing, Regulated by E3 Ubiquitin Ligase FBXW7, Alleviates Endothelial Dysfunction and Inflammation Through Inhibiting the Nuclear Translocation of p65 and IRF3: A Possible Therapeutic Approach for Atherosclerosis.
Xing Z, Zhen Y, Chen J, Du M, Li D, Liu R, Zheng J
Inflammation 2023 Dec;46(6):2071-2088
Inflammation 2023 Dec;46(6):2071-2088
Human umbilical cord mesenchymal stem cell exosomes alleviate acute kidney injury by inhibiting pyroptosis in rats and NRK-52E cells.
Wan Y, Yu Y, Yu C, Luo J, Wen S, Shen L, Wei G, Hua Y
Renal failure 2023 Dec;45(1):2221138
Renal failure 2023 Dec;45(1):2221138
Exoskeleton Partial-Coated Stem Cells for Infarcted Myocardium Restoring.
He H, Yuan Y, Wu Y, Lu J, Yang X, Lu K, Liu A, Cao Z, Sun M, Yu M, Wang H
Advanced materials (Deerfield Beach, Fla.) 2023 Dec;35(52):e2307169
Advanced materials (Deerfield Beach, Fla.) 2023 Dec;35(52):e2307169
Vitamin D3 alleviates lung fibrosis of type 2 diabetic rats via SIRT3 mediated suppression of pyroptosis.
Tang L, Zhang D, Zhang Y, Peng Y, Li M, Song H, Chen H, Li W, Li X
Apoptosis : an international journal on programmed cell death 2023 Dec;28(11-12):1618-1627
Apoptosis : an international journal on programmed cell death 2023 Dec;28(11-12):1618-1627
Polydatin alleviates bleomycin-induced pulmonary fibrosis and alters the gut microbiota in a mouse model.
Yang J, Shi X, Gao R, Fan L, Chen R, Cao Y, Xu T, Yang J
Journal of cellular and molecular medicine 2023 Dec;27(23):3717-3728
Journal of cellular and molecular medicine 2023 Dec;27(23):3717-3728
Engineered muscle from micro-channeled PEG scaffold with magnetic Fe(3)O(4) fixation towards accelerating esophageal muscle repair.
Luo Y, Chen Y, Gu Z, Ni R, Feng P, Hu Z, Song L, Shen X, Gu C, Li J, Du T, Yang L, Zhang H, Zhu Y
Materials today. Bio 2023 Dec;23:100853
Materials today. Bio 2023 Dec;23:100853
Polyethylene glycol crosslinked decellularized single liver lobe scaffolds with vascular endothelial growth factor promotes angiogenesis in vivo.
Zhang JS, Wang ZB, Lai ZZ, Yang JW, Song WJ, Wei YB, Mei J, Wang JG
Hepatobiliary & pancreatic diseases international : HBPD INT 2023 Dec;22(6):622-631
Hepatobiliary & pancreatic diseases international : HBPD INT 2023 Dec;22(6):622-631
Overexpression of LOX-1 in hepatocytes protects vascular smooth muscle cells from phenotype transformation and wire injury induced carotid neoatherosclerosis through ALOX15.
Zhang Q, Du G, Tong L, Guo X, Wei Y
Biochimica et biophysica acta. Molecular basis of disease 2023 Dec;1869(8):166805
Biochimica et biophysica acta. Molecular basis of disease 2023 Dec;1869(8):166805
Triptolide attenuates CCL(4)-induced liver fibrosis by regulating the differentiation of CD(4)(+) T cells in mice.
Jiang S, Feng J, Jiang Y, Lu Z, Kong J, Li X, Lian H, Zhang F, Li Y, Li J
International immunopharmacology 2023 Dec;125(Pt B):111206
International immunopharmacology 2023 Dec;125(Pt B):111206
BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK-1/Egr-1 axis.
Chen W, Zhao S, Xing J, Yu W, Rao T, Zhou X, Ruan Y, Li S, Xia Y, Song T, Zou F, Li W, Cheng F
International immunopharmacology 2023 Dec;125(Pt B):111140
International immunopharmacology 2023 Dec;125(Pt B):111140
Sodium alginate combined with oxymatrine ameliorates CCl(4)-induced chemical hepatic fibrosis in mice.
He C, Wang W, Wei G, Wang Y, Wei Y, Wang J, Zhang Z
International immunopharmacology 2023 Dec;125(Pt A):111144
International immunopharmacology 2023 Dec;125(Pt A):111144
Tamoxifen induced cardiac damage via the IL-6/p-STAT3/PGC-1α pathway.
Meng T, Zhang D, Zhang Y, Tian P, Chen J, Liu A, Li Y, Song C, Zheng Y, Su G
International immunopharmacology 2023 Dec;125(Pt A):110978
International immunopharmacology 2023 Dec;125(Pt A):110978
Isovitexin alleviates hepatic fibrosis by regulating miR-21-mediated PI3K/Akt signaling and glutathione metabolic pathway: based on transcriptomics and metabolomics.
Huang Y, Luo W, Chen S, Su H, Zhu W, Wei Y, Qiu Y, Long Y, Shi Y, Wei J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155117
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155117
Oleanolic acid derivative alleviates cardiac fibrosis through inhibiting PTP1B activity and regulating AMPK/TGF-β/Smads pathway.
Wang AH, Ma HY, Yi YL, Zhu SJ, Yu ZW, Zhu J, Mei S, Bahetibike S, Lu YQ, Huang LT, Yang RY, Rui-Wang, Xiao SL, Qi R
European journal of pharmacology 2023 Dec 5;960:176116
European journal of pharmacology 2023 Dec 5;960:176116
Suppressive effect of nitric oxide synthase (NOS) inhibitor L-NMMA acetate on choroidal fibrosis in experimental myopic guinea pigs through the nitric oxide signaling pathway.
Li T, Bao B, Hao Y, Liu J, Bi H, Guo D
European journal of pharmacology 2023 Dec 5;960:176111
European journal of pharmacology 2023 Dec 5;960:176111
The Long non-coding RNA MALAT1 functions as a competing endogenous RNA to regulate vascular remodeling by sponging miR-145-5p/HK2 in hypertension.
Yang J, Jiang G, Huang L, Liu Z, Jiang R, Cao G, Cao J, Zhu H, Chen L, Chen X, Pei F
Clinical and experimental hypertension (New York, N.Y. : 1993) 2023 Dec 31;45(1):2284658
Clinical and experimental hypertension (New York, N.Y. : 1993) 2023 Dec 31;45(1):2284658
Canagliflozin ameliorates hypobaric hypoxia-induced pulmonary arterial hypertension by inhibiting pulmonary arterial smooth muscle cell proliferation.
Tang L, Cai Q, Wang X, Li X, Li X, Chen L, Yang Y
Clinical and experimental hypertension (New York, N.Y. : 1993) 2023 Dec 31;45(1):2278205
Clinical and experimental hypertension (New York, N.Y. : 1993) 2023 Dec 31;45(1):2278205
CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells.
Yu W, Zhang Q, Qiu Y, Chen H, Huang X, Xiao L, Xu G, Li S, Hu P, Tong X
Clinical and experimental hypertension (New York, N.Y. : 1993) 2023 Dec 31;45(1):2272062
Clinical and experimental hypertension (New York, N.Y. : 1993) 2023 Dec 31;45(1):2272062
Muscone inhibits angiotensin II-induced cardiac hypertrophy through the STAT3, MAPK and TGF-β/SMAD signaling pathways.
Liu YJ, Xu JJ, Yang C, Li YL, Chen MW, Liu SX, Zheng XH, Luo P, Li R, Xiao D, Shan ZG
Molecular biology reports 2023 Dec 29;51(1):39
Molecular biology reports 2023 Dec 29;51(1):39
Exosomal ITGB6 from dormant lung adenocarcinoma cells activates cancer-associated fibroblasts by KLF10 positive feedback loop and the TGF-β pathway.
Feng X, Liu X, Xiang J, Xu J, Yin N, Wang L, Liu C, Liu Y, Zhao T, Zhao Z, Gao Y
Translational lung cancer research 2023 Dec 26;12(12):2520-2537
Translational lung cancer research 2023 Dec 26;12(12):2520-2537
Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz (Wwtr1) Activation in Male LDLR-/- Mice.
Behrmann A, Zhong D, Li L, Xie S, Mead M, Sabaeifard P, Goodarzi M, Lemoff A, Kozlitina J, Towler DA
Endocrinology 2023 Dec 23;165(2)
Endocrinology 2023 Dec 23;165(2)
Biodegradable nano black phosphorus based SDF1-α delivery system ameliorates Erectile Dysfunction in a cavernous nerve injury rat model by recruiting endogenous stem/progenitor cells.
Fu Q, Song L, Li J, Yi B, Huang Y, Zhang Z, Xin Z, Zhu J
Journal of nanobiotechnology 2023 Dec 18;21(1):487
Journal of nanobiotechnology 2023 Dec 18;21(1):487
A multi-functional double cross-linked chitosan hydrogel with tunable mechanical and antibacterial properties for skin wound dressing.
Liu F, Wang L, Zhai X, Ji S, Ye J, Zhu Z, Teng C, Dong W, Wei W
Carbohydrate polymers 2023 Dec 15;322:121344
Carbohydrate polymers 2023 Dec 15;322:121344
Anti-VEGFR2 F(ab')(2) drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy.
Liu D, Song Y, Chen H, You Y, Zhu L, Zhang J, Xu X, Hu J, Huang X, Wu X, Xu X, Jiang S, Du Y
Nature communications 2023 Dec 13;14(1):8268
Nature communications 2023 Dec 13;14(1):8268
Hepatic Stellate Cell- and Liver Microbiome-Specific Delivery System for Dihydrotanshinone I to Ameliorate Liver Fibrosis.
Niu X, Meng Y, Cui J, Li R, Ding X, Niu B, Chang G, Xu N, Li G, Wang Y, Wang L
ACS nano 2023 Dec 12;17(23):23608-23625
ACS nano 2023 Dec 12;17(23):23608-23625
The application of a novel platform of multiparametric magnetic resonance imaging in a bioenvironmental toxic carbon tetrachloride-induced mouse model of liver fibrosis.
Qiuling L, Qilin Y, Cheng Y, Minping Z, Kangning W, Enhua X
Environmental research 2023 Dec 1;238(Pt 1):117130
Environmental research 2023 Dec 1;238(Pt 1):117130
Cell and rat serum, urine and tissue metabolomics analysis elucidates the key pathway changes associated with chronic nephropathy and reveals the mechanism of action of rhein.
Wang L, Yu X, Li H, He D, Zeng S, Xiang Z
Chinese medicine 2023 Dec 1;18(1):158
Chinese medicine 2023 Dec 1;18(1):158
Ginsenoside Rg1 Alleviates Lipopolysaccharide-Induced Fibrosis of Endometrial Epithelial Cells in Dairy Cows by Inhibiting Reactive Oxygen Species-Activated NLRP3.
Song L, Wang L, Li X, Xiao L
Animals : an open access journal from MDPI 2023 Dec 1;13(23)
Animals : an open access journal from MDPI 2023 Dec 1;13(23)
＜Editors' Choice＞ Supernatant from activated omentum accelerates wound healing in diabetic mice wound model.
Li Y, Hashikawa K, Ebisawa K, Kambe M, Higuchi S, Kamei Y
Nagoya journal of medical science 2023 Aug;85(3):528-541
Nagoya journal of medical science 2023 Aug;85(3):528-541
Dipeptidase‑2 is a prognostic marker in lung adenocarcinoma that is correlated with its sensitivity to cisplatin.
Wang Y, Zhang T, Du H, Yang M, Xie G, Liu T, Deng S, Yuan W, He S, Wu D, Xu Y
Oncology reports 2023 Aug;50(2)
Oncology reports 2023 Aug;50(2)
Testosterone attenuates senile cavernous fibrosis by regulating TGFβR1 and galectin-1 signaling pathways through miR-22-3p.
Hu Z, Zhang Y, Chen J, Luo M, Wang N, Xiao Y, He Q
Molecular and cellular biochemistry 2023 Aug;478(8):1791-1802
Molecular and cellular biochemistry 2023 Aug;478(8):1791-1802
Salvianolic Acid B Attenuates Hypertrophic Scar Formation In Vivo and In Vitro.
Chong CH, Sun JM, Liu YX, Tsai YT, Zheng DN, Zhang YF, Yu L
Aesthetic plastic surgery 2023 Aug;47(4):1587-1597
Aesthetic plastic surgery 2023 Aug;47(4):1587-1597
sST2: A Bridge Between Sirt1/p53/p21 Signal-Induced Senescence and TGF-β1/Smad2/3 Regulation of Cardiac Fibrosis in Mouse Viral Myocarditis.
Tan J, Wei J, Lu H
Inflammation 2023 Aug;46(4):1305-1317
Inflammation 2023 Aug;46(4):1305-1317
Transcription factor 21 accelerates vascular calcification in mice by activating the IL-6/STAT3 signaling pathway and the interplay between VSMCs and ECs.
Zhao XK, Zhu MM, Wang SN, Zhang TT, Wei XN, Wang CY, Zheng J, Zhu WY, Jiang MX, Xu SW, Yang XX, Duan YJ, Zhang BC, Han JH, Miao QR, Hu H, Chen YL
Acta pharmacologica Sinica 2023 Aug;44(8):1625-1636
Acta pharmacologica Sinica 2023 Aug;44(8):1625-1636
Kangfuxin Accelerates Extraction Socket Healing by Promoting Angiogenesis Via Upregulation of CCL2 in Stem Cells.
Gao ZR, Zhou YH, Zhao YQ, Zhao J, Ye Q, Zhang SH, Feng Y, Tan L, Liu Q, Chen Y, Ouyang ZY, Hu J, Dusenge MA, Feng YZ, Guo Y
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Aug;38(8):1208-1221
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2023 Aug;38(8):1208-1221
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
Wang X, Zhou Y, Sun Q, Zhang Q, Zhou H, Zhang J, Du Y, Wang Y, Yuan K, Xu L, Zhang M, Yan D, Zeng L, Xu K, Sang W
Transplantation and cellular therapy 2023 Aug;29(8):492.e1-492.e10
Transplantation and cellular therapy 2023 Aug;29(8):492.e1-492.e10
Sustained release of magnesium and zinc ions synergistically accelerates wound healing.
Yang F, Xue Y, Wang F, Guo D, He Y, Zhao X, Yan F, Xu Y, Xia D, Liu Y
Bioactive materials 2023 Aug;26:88-101
Bioactive materials 2023 Aug;26:88-101
Crosstalk between Interleukin-1 Receptor-Like 1 and Transforming Growth Factor-β Receptor Signaling Promotes Renal Fibrosis.
Zhu X, Lu J, Rao J, Ru D, Gao M, Shi D, Cao K, Wen S, Dai C, Wang X, Mi W, Liu L, Zhou H
The American journal of pathology 2023 Aug;193(8):1029-1045
The American journal of pathology 2023 Aug;193(8):1029-1045
p53 deacetylation alleviates calcium oxalate deposition-induced renal fibrosis by inhibiting ferroptosis.
Ye Z, Xia Y, Li L, Li B, Chen L, Yu W, Ruan Y, Rao T, Zhou X, Cheng F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114925
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114925
Ginsenoside Rg1 ameliorates hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and inflammation by regulating CCN1.
Tang BL, Liu Y, Zhang JL, Lu ML, Wang HX
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114920
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114920
Genetic and pharmacological inhibition of METTL3 alleviates renal fibrosis by reducing EVL m6A modification through an IGF2BP2-dependent mechanism.
Ni WJ, Zhou H, Lu H, Ma NN, Hou BB, Li W, Kong FX, Yu JT, Hou R, Jin J, Wen JG, Zhang T, Meng XM
Clinical and translational medicine 2023 Aug;13(8):e1359
Clinical and translational medicine 2023 Aug;13(8):e1359
Amelioratory effects of astragaloside IV on hepatocarcinogenesis via Nrf2-mediated pSmad3C/3L transformation.
Fang Gong Y, Hou S, Xu JC, Chen Y, Zhu LL, Xu YY, Chen YQ, Li MM, Li LL, Yang JJ, Yang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Aug;117:154903
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Aug;117:154903
Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancer.
Quan Y, He J, Zou Q, Zhang L, Sun Q, Huang H, Li W, Xie K, Wei F
Journal for immunotherapy of cancer 2023 Aug;11(8)
Journal for immunotherapy of cancer 2023 Aug;11(8)
NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.
Qiu D, Song S, Chen N, Bian Y, Yuan C, Zhang W, Duan H, Shi Y
Cellular signalling 2023 Aug;108:110712
Cellular signalling 2023 Aug;108:110712
N-acetyltransferase 10 promotes cutaneous wound repair via the NF-κB-IL-6 axis.
Wang B, Zhang J, Li G, Xu C, Yang L, Zhang J, Wu Y, Liu Y, Liu Z, Wang M, Li J, Tang X, Liu B
Cell death discovery 2023 Aug 29;9(1):324
Cell death discovery 2023 Aug 29;9(1):324
Baricitinib improves pulmonary fibrosis in mice with rheumatoid arthritis-associated interstitial lung disease by inhibiting the Jak2/Stat3 signaling pathway.
Liu H, Yang Y, Zhang J, Li X
Advances in rheumatology (London, England) 2023 Aug 28;63(1):45
Advances in rheumatology (London, England) 2023 Aug 28;63(1):45
CXCL8 Promotes Endothelial-to-Mesenchymal Transition of Endothelial Cells and Protects Cells from Erastin-Induced Ferroptosis via CXCR2-Mediated Activation of the NF-κB Signaling Pathway.
Ji HZ, Chen L, Ren M, Li S, Liu TY, Chen HJ, Yu HH, Sun Y
Pharmaceuticals (Basel, Switzerland) 2023 Aug 25;16(9)
Pharmaceuticals (Basel, Switzerland) 2023 Aug 25;16(9)
Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis.
Zhang S, Fang W, Zhou S, Zhu D, Chen R, Gao X, Li Z, Fu Y, Zhang Y, Yang F, Zhao J, Wu H, Wang P, Shen Y, Shen S, Xu G, Wang L, Yan C, Zou X, Chen D, Lv Y
Nature communications 2023 Aug 23;14(1):5123
Nature communications 2023 Aug 23;14(1):5123
Exosomal miR-103a-3p from Crohn's Creeping Fat-Derived Adipose-Derived Stem Cells Contributes to Intestinal Fibrosis by Targeting TGFBR3 and Activating Fibroblasts.
Qian W, Xu Y, Wen W, Huang L, Guo Z, Zhu W, Li Y
Journal of Crohn's & colitis 2023 Aug 21;17(8):1291-1308
Journal of Crohn's & colitis 2023 Aug 21;17(8):1291-1308
UCP1 alleviates renal interstitial fibrosis progression through oxidative stress pathway mediated by SIRT3 protein stability.
Xiong W, Xiong Z, Song A, Lei C, Ye C, Su H, Zhang C
Journal of translational medicine 2023 Aug 2;21(1):521
Journal of translational medicine 2023 Aug 2;21(1):521
Carcinoma-associated fibroblast-derived lysyl oxidase-rich extracellular vesicles mediate collagen crosslinking and promote epithelial-mesenchymal transition via p-FAK/p-paxillin/YAP signaling.
Liu X, Li J, Yang X, Li X, Kong J, Qi D, Zhang F, Sun B, Liu Y, Liu T
International journal of oral science 2023 Aug 2;15(1):32
International journal of oral science 2023 Aug 2;15(1):32
Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing.
Lv D, Cao X, Zhong L, Dong Y, Xu Z, Rong Y, Xu H, Wang Z, Yang H, Yin R, Chen M, Ke C, Hu Z, Deng W, Tang B
Cell reports. Medicine 2023 Aug 15;4(8):101129
Cell reports. Medicine 2023 Aug 15;4(8):101129
TNFSF14/LIGHT promotes cardiac fibrosis and atrial fibrillation vulnerability via PI3Kγ/SGK1 pathway-dependent M2 macrophage polarisation.
Wu Y, Zhan S, Chen L, Sun M, Li M, Mou X, Zhang Z, Xu L, Xu Y
Journal of translational medicine 2023 Aug 14;21(1):544
Journal of translational medicine 2023 Aug 14;21(1):544
METTL14 reverses liver fibrosis by inhibiting NOVA2 through an m6A-YTHDF2-dependent mechanism.
Hou X, Li Y, Song J, Peng L, Zhang W, Liu R, Yuan H, Feng T, Li J, Li W, Zhu C
Hepatology communications 2023 Aug 1;7(8)
Hepatology communications 2023 Aug 1;7(8)
Effect of roflumilast on airway remodeling in asthmatic mice exposed to or not exposed to cigarette smoke: Comparison with the effect of dexamethasone.
Takeda Y, Takahashi M, Fuchikami JI, Nakamura H, Aoshiba K
Pulmonary pharmacology & therapeutics 2023 Apr;79:102198
Pulmonary pharmacology & therapeutics 2023 Apr;79:102198
MicroRNA-146a Promotes Embryonic Stem Cell Differentiation towards Vascular Smooth Muscle Cells through Regulation of Kruppel-like Factor 4.
Zhang Q, Pan RR, Wu YT, Wei YM
Current medical science 2023 Apr;43(2):223-231
Current medical science 2023 Apr;43(2):223-231
Myocardin Reverses Hypoxia-Inducible Factor-1α Mediated Phenotypic Modulation of Corpus Cavernosum Smooth Muscle Cells in Hypoxia Induced by Cobalt Chloride.
Zhou X, Luo C, Fan J, Gao G, Wang T, Zhang H, Wei A
The world journal of men's health 2023 Apr;41(2):363-372
The world journal of men's health 2023 Apr;41(2):363-372
Restoration of Sinusoid Fenestrae Followed by Targeted Nanoassembly Delivery of an Anti-Fibrotic Agent Improves Treatment Efficacy in Liver Fibrosis.
Li F, Zhao Y, Cheng Z, Wang Y, Yue Y, Cheng X, Sun J, Atabakhshi-Kashi M, Yao J, Dou J, Yu J, Zhang X, Qi Y, Li X, Qi X, Nie G
Advanced materials (Deerfield Beach, Fla.) 2023 Apr;35(17):e2212206
Advanced materials (Deerfield Beach, Fla.) 2023 Apr;35(17):e2212206
Biomimetic nanoparticles drive the mechanism understanding of shear-wave elasticity stiffness in triple negative breast cancers to predict clinical treatment.
Zheng D, Zhou J, Qian L, Liu X, Chang C, Tang S, Zhang H, Zhou S
Bioactive materials 2023 Apr;22:567-587
Bioactive materials 2023 Apr;22:567-587
Breach of tolerance versus burden of bile acids: Resolving the conundrum in the immunopathogenesis and natural history of primary biliary cholangitis.
Yamashita M, Honda A, Shimoyama S, Umemura M, Ohta K, Chida T, Noritake H, Kurono N, Ichimura-Shimizu M, Tsuneyama K, Miyazaki T, Tanaka A, Leung PSC, Gershwin ME, Suda T, Kawata K
Journal of autoimmunity 2023 Apr;136:103027
Journal of autoimmunity 2023 Apr;136:103027
A novel co-culture assay to evaluate the effects of sympathetic innervation on vascular smooth muscle differentiation.
Jafarkhani S, Khakbiz M, Amoabediny G, Mohammadi J, Tahmasebipour M, Rabbani H, Salimi A, Lee KB
Bioorganic chemistry 2023 Apr;133:106233
Bioorganic chemistry 2023 Apr;133:106233
Fate mapping RNA-sequencing reveal Malat1 regulates Sca1(+) progenitor cells to vascular smooth muscle cells transition in vascular remodeling.
Lyu L, Li Z, Wen Z, He Y, Wang X, Jiang L, Zhou X, Huang C, Wu Y, Chen T, Guo X
Cellular and molecular life sciences : CMLS 2023 Apr 6;80(5):118
Cellular and molecular life sciences : CMLS 2023 Apr 6;80(5):118
Active ingredients screening and pharmacological mechanism research of curcumae rhizoma-sparganii rhizoma herb pair ameliorates liver fibrosis based on network pharmacology.
Hao M, Yao Z, Zhao M, Chen Z, Wang P, Sang X, Yang Q, Wang K, Han X, Cao G
Journal of ethnopharmacology 2023 Apr 6;305:116111
Journal of ethnopharmacology 2023 Apr 6;305:116111
SCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice.
Zheng G, Su Y, Wei L, Yao Y, Wang Y, Luo X, Wang X, Ruan XZ, Li D, Chen Y
Cell death & disease 2023 Apr 6;14(4):249
Cell death & disease 2023 Apr 6;14(4):249
Fasudil alleviates the vascular endothelial dysfunction and several phenotypes of Fabry disease.
Choi JB, Seol DW, Do HS, Yang HY, Kim TM, Byun YG, Park JM, Choi J, Hong SP, Chung WS, Suh JM, Koh GY, Lee BH, Wee G, Han YM
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Apr 5;31(4):1002-1016
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Apr 5;31(4):1002-1016
Continuous Monochromatic Blue Light Exacerbates High-Fat Diet-Induced Kidney Injury via Corticosterone-Mediated Oxidative Stress.
Ren W, Wang Z, Cao J, Dong Y, Wang T, Chen Y
Antioxidants (Basel, Switzerland) 2023 Apr 28;12(5)
Antioxidants (Basel, Switzerland) 2023 Apr 28;12(5)
Activation of NRF2 Signaling Pathway Delays the Progression of Hyperuricemic Nephropathy by Reducing Oxidative Stress.
Qiao P, Sun Y, Wang Y, Lin S, An Y, Wang L, Liu J, Huang Y, Yang B, Zhou H
Antioxidants (Basel, Switzerland) 2023 Apr 28;12(5)
Antioxidants (Basel, Switzerland) 2023 Apr 28;12(5)
Establishment of a Rat Model of Liver Venous Deprivation: Simultaneous Portal and Hepatic Vein Ligation.
Zhang Y, He X, Ma P, Xiong L, Bai W, Zhang G, Xu Y, Song W, Yu K
Journal of clinical and translational hepatology 2023 Apr 28;11(2):393-404
Journal of clinical and translational hepatology 2023 Apr 28;11(2):393-404
Two-Pore-Domain Potassium Channel TREK-1 Mediates Pulmonary Fibrosis through Macrophage M2 Polarization and by Direct Promotion of Fibroblast Differentiation.
Zhang Y, Fu J, Han Y, Feng D, Yue S, Zhou Y, Luo Z
Biomedicines 2023 Apr 26;11(5)
Biomedicines 2023 Apr 26;11(5)
Jia-Wei-Si-Miao-Yong-An Fang stimulates the healing of acute radiation-induced cutaneous wounds through MAPK/ERK pathway.
Wang Y, Gao J, Sun L, Li Q, Kang N, Gao C, Li T
Journal of ethnopharmacology 2023 Apr 24;306:116180
Journal of ethnopharmacology 2023 Apr 24;306:116180
Synergistic effect of constituent drugs of Baibutang on improving Yin-deficiency pulmonary fibrosis in rats.
Fu S, Song X, Tang X, Qian X, Du Z, Hu Y, Xu X, Zhang M
Journal of ethnopharmacology 2023 Apr 24;306:116050
Journal of ethnopharmacology 2023 Apr 24;306:116050
Progerinin, an Inhibitor of Progerin, Alleviates Cardiac Abnormalities in a Model Mouse of Hutchinson-Gilford Progeria Syndrome.
Kang SM, Seo S, Song EJ, Kweon O, Jo AH, Park S, Woo TG, Kim BH, Oh GT, Park BJ
Cells 2023 Apr 24;12(9)
Cells 2023 Apr 24;12(9)
Histone lactylation driven by mROS-mediated glycolytic shift promotes hypoxic pulmonary hypertension.
Chen J, Zhang M, Liu Y, Zhao S, Wang Y, Wang M, Niu W, Jin F, Li Z
Journal of molecular cell biology 2023 Apr 20;14(12)
Journal of molecular cell biology 2023 Apr 20;14(12)
Brevilin A is a potent anti-metastatic CRC agent that targets the VEGF-IL6-STAT3 axis in the HSCs-CRC interplay.
Fan X, Meng M, Li B, Chen H, Tan J, Xu K, Xiao S, Kwan HY, Liu Z, Su T
Journal of translational medicine 2023 Apr 16;21(1):260
Journal of translational medicine 2023 Apr 16;21(1):260
GL-V9 ameliorates liver fibrosis by inhibiting TGF-β/smad pathway.
Guo Y, Tian G, Chen X, Hou Y, Zhang X, Xue X, Zhao L, Wu Y
Experimental cell research 2023 Apr 1;425(1):113521
Experimental cell research 2023 Apr 1;425(1):113521
Selective Inhibition of Histone Deacetylase Class IIa With MC1568 Ameliorates Podocyte Injury.
He X, Sun T, Zhang P, Xia Z, Gao C, Ren H, Ji D
Frontiers in medicine 2022;9:848938
Frontiers in medicine 2022;9:848938
Deciphering Key Foreign Body Reaction-Related Transcription Factors and Genes Through Transcriptome Analysis.
Liu W, Xiong S, Du J, Song Y, Wang T, Zhang Y, Dong C, Huang Z, He Q, Yu Z, Ma X
Frontiers in molecular biosciences 2022;9:843391
Frontiers in molecular biosciences 2022;9:843391
Establishment of a New Abdominal Aortic Aneurysm Model in Rats by a Retroperitoneal Approach.
Zhu JX, Tang QQ, Zhou C, Shi XC, Yi SY, Yang Y
Frontiers in cardiovascular medicine 2022;9:808732
Frontiers in cardiovascular medicine 2022;9:808732
Anti-fibrotic effect of extracellular vesicles derived from tea leaves in hepatic stellate cells and liver fibrosis mice.
Gong Q, Zeng Z, Jiang T, Bai X, Pu C, Hao Y, Guo Y
Frontiers in nutrition 2022;9:1009139
Frontiers in nutrition 2022;9:1009139
Hepatoblastoma: Derived Exosomal LncRNA NEAT1 Induces BMSCs Differentiation into Tumor-Supporting Myofibroblasts via Modulating the miR-132/MMP9 Axis.
Hu Y, Zai H, Jiang W, Ou Z, Yao Y, Zhu Q
Journal of oncology 2022;2022:7630698
Journal of oncology 2022;2022:7630698
C/EBPα-Mediated Transcriptional Activation of PIK3C2A Regulates Autophagy, Matrix Metalloproteinase Expression, and Phenotypic of Vascular Smooth Muscle Cells in Aortic Dissection.
Lu H, Chen Y, Chen Y, Huang L, Chen L
Journal of immunology research 2022;2022:7465353
Journal of immunology research 2022;2022:7465353
Targeting Ferroptosis Attenuates Inflammation, Fibrosis, and Mast Cell Activation in Chronic Prostatitis.
Lin D, Zhang M, Luo C, Wei P, Cui K, Chen Z
Journal of immunology research 2022;2022:6833867
Journal of immunology research 2022;2022:6833867
Blocking REDD1/TXNIP Complex Ameliorates HG-Induced Renal Tubular Epithelial Cell Apoptosis and EMT through Repressing Oxidative Stress.
Mu L, Chen N, Chen Y, Yang Z, Zhou H, Song S, Shi Y
International journal of endocrinology 2022;2022:6073911
International journal of endocrinology 2022;2022:6073911
The Traditional Chinese Medicine Formula FTZ Protects against Cardiac Fibrosis by Suppressing the TGFβ1-Smad2/3 Pathway.
Zhang Y, Wang D, Wu K, Shao X, Diao H, Wang Z, Sun M, Huang X, Li Y, Tang X, Yan M, Guo J
Evidence-based complementary and alternative medicine : eCAM 2022;2022:5642307
Evidence-based complementary and alternative medicine : eCAM 2022;2022:5642307
Hsa_circRNA_0008028 Deficiency Ameliorates High Glucose-Induced Proliferation, Calcification, and Autophagy of Vascular Smooth Muscle Cells via miR-182-5p/TRIB3 Axis.
Shi L, Li Y, Shi M, Li X, Li G, Cen J, Liu D, Wei C, Lin Y
Oxidative medicine and cellular longevity 2022;2022:5142381
Oxidative medicine and cellular longevity 2022;2022:5142381
p16(INK4a) Plays Critical Role in Exacerbating Inflammaging in High Fat Diet Induced Skin.
Liang Y, Gu T, Peng S, Lin Y, Liu J, Wang X, Huang X, Zhang X, Zhu J, Zhao L, Fan C, Wang G, Gu X, Lin J
Oxidative medicine and cellular longevity 2022;2022:3415528
Oxidative medicine and cellular longevity 2022;2022:3415528
HBO1 as an Important Target for the Treatment of CCL4-Induced Liver Fibrosis and Aged-Related Liver Aging and Fibrosis.
Xing B, Lan H, Li H
Oxidative medicine and cellular longevity 2022;2022:1881519
Oxidative medicine and cellular longevity 2022;2022:1881519
Qufeng Xuanbi Formula Ameliorates Airway Remodeling in Asthmatic Mice by Suppressing Airway Smooth Muscle Cell Proliferation through MEK/ERK Signaling Pathway.
Wang B, Tang L, Shi S, Yang Y, Sun X, Zhang X, Liu C, Liu L
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1525110
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1525110
Tissue Kallikrein Protects Rat Prostate against the Inflammatory Damage in a Chronic Autoimmune Prostatitis Model via Restoring Endothelial Function in a Bradykinin Receptor B2-Dependent Way.
Zhang M, Lin D, Luo C, Wei P, Cui K, Chen Z
Oxidative medicine and cellular longevity 2022;2022:1247806
Oxidative medicine and cellular longevity 2022;2022:1247806
Blockade of SK4 channels suppresses atrial fibrillation by attenuating atrial fibrosis in canines with prolonged atrial pacing.
Wang Y, Yao Y, Ma Y, He S, Yang M, Cao Z, Liudi S, Fu Y, Chen H, Wang X, Huang C, Zhao Q
International journal of medical sciences 2022;19(14):1995-2007
International journal of medical sciences 2022;19(14):1995-2007
Commensal microbe-derived SCFA alleviates atrial fibrillation via GPR43/NLRP3 signaling.
Zuo K, Fang C, Liu Z, Fu Y, Liu Y, Liu L, Wang Y, Yin X, Liu X, Li J, Zhong J, Chen M, Xu L, Yang X
International journal of biological sciences 2022;18(10):4219-4232
International journal of biological sciences 2022;18(10):4219-4232
Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/β-catenin pathway.
Zhang ZY, Zhai C, Yang XY, Li HB, Wu LL, Li L
PloS one 2022;17(8):e0273542
PloS one 2022;17(8):e0273542
The conditioned medium from mesenchymal stromal cells pretreated with proinflammatory cytokines promote fibroblasts migration and activation.
Liu C, Wang C, Yang F, Lu Y, Du P, Hu K, Yin X, Zhao P, Lu G
PloS one 2022;17(4):e0265049
PloS one 2022;17(4):e0265049
Exosome Derived from Mesenchymal Stem Cells Alleviates Pathological Scars by Inhibiting the Proliferation, Migration and Protein Expression of Fibroblasts via Delivering miR-138-5p to Target SIRT1.
Zhao W, Zhang R, Zang C, Zhang L, Zhao R, Li Q, Yang Z, Feng Z, Zhang W, Cui R
International journal of nanomedicine 2022;17:4023-4038
International journal of nanomedicine 2022;17:4023-4038
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
Li Y, Li C, Xiong Y, Fang B, Lin X, Huang Q
Drug design, development and therapy 2022;16:1713-1729
Drug design, development and therapy 2022;16:1713-1729
Regenerative Peripheral Nerve Interfaces Effectively Prevent Neuroma Formation After Sciatic Nerve Transection in Rats.
Wu J, Zhang Y, Zhang X, Lin Z, Li G
Frontiers in molecular neuroscience 2022;15:938930
Frontiers in molecular neuroscience 2022;15:938930
Metformin Ameliorates Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells in Diabetes by Increasing Vitamin D Receptor Expression.
Wen W, Huang B, Ye S
Diabetes, metabolic syndrome and obesity : targets and therapy 2022;15:4001-4010
Diabetes, metabolic syndrome and obesity : targets and therapy 2022;15:4001-4010
Macrophage SCAP Contributes to Metaflammation and Lean NAFLD by Activating STING-NF-κB Signaling Pathway.
Huang X, Yao Y, Hou X, Wei L, Rao Y, Su Y, Zheng G, Ruan XZ, Li D, Chen Y
Cellular and molecular gastroenterology and hepatology 2022;14(1):1-26
Cellular and molecular gastroenterology and hepatology 2022;14(1):1-26
Heidihuangwan alleviates renal fibrosis in rats with 5/6 nephrectomy by inhibiting autophagy.
Li YY, Tian ZH, Pan GH, Zhao P, Pan DJ, Zhang JQ, Ye LY, Zhang FR, Xu XD
Frontiers in pharmacology 2022;13:977284
Frontiers in pharmacology 2022;13:977284
Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling.
Huang Q, Xiao R, Lu J, Zhang Y, Xu L, Gao J, Sun J, Wang H
Frontiers in pharmacology 2022;13:973182
Frontiers in pharmacology 2022;13:973182
Inhibition of calpain9 attenuates peritoneal dialysis-related peritoneal fibrosis.
Li F, Wang Y, Tian J, Zhou Z, Yin W, Qin X, Wang H, Zeng T, Li A, Jiang J
Frontiers in pharmacology 2022;13:962770
Frontiers in pharmacology 2022;13:962770
TIM-4 in macrophages contributes to nasal polyp formation through the TGF-β1-mediated epithelial to mesenchymal transition in nasal epithelial cells.
Qin D, Liu P, Zhou H, Jin J, Gong W, Liu K, Chen S, Huang J, Fan W, Tao Z, Xu Y
Frontiers in immunology 2022;13:941608
Frontiers in immunology 2022;13:941608
Inhibition of HDAC6 With CAY10603 Ameliorates Diabetic Kidney Disease by Suppressing NLRP3 Inflammasome.
Hou Q, Kan S, Wang Z, Shi J, Zeng C, Yang D, Jiang S, Liu Z
Frontiers in pharmacology 2022;13:938391
Frontiers in pharmacology 2022;13:938391
Ganfule capsule alleviates bile duct ligation-induced liver fibrosis in mice by inhibiting glutamine metabolism.
Ke C, Gao J, Tu J, Wang Y, Xiao Y, Wu Y, Liu Y, Zhou Z
Frontiers in pharmacology 2022;13:930785
Frontiers in pharmacology 2022;13:930785
Akkermansia muciniphila Alters Gut Microbiota and Immune System to Improve Cardiovascular Diseases in Murine Model.
He X, Bai Y, Zhou H, Wu K
Frontiers in microbiology 2022;13:906920
Frontiers in microbiology 2022;13:906920
Beneficial Effect of Edoxaban on Preventing Atrial Fibrillation and Coagulation by Reducing Inflammation via HBG1/HBD Biomarkers.
Yang C, Wang X, Guo Y, Meng X, Li Y, Xia C, Meng L, Dong M, Wang F
Frontiers in pharmacology 2022;13:904317
Frontiers in pharmacology 2022;13:904317
Mechanism of Endoplasmic Reticulum Stress Pathway in the Osteogenic Phenotypic Transformation of Aortic Valve Interstitial Cells.
Tao Y, Geng Y, Dang W, Xu X, Zhao H, Zou L, Li Y
Frontiers in endocrinology 2022;13:856331
Frontiers in endocrinology 2022;13:856331
Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3/p-STAT3/GLUT1 Signaling Pathway.
Li Z, Geng J, Xie B, He J, Wang J, Peng L, Hu Y, Dai H, Wang C
Frontiers in pharmacology 2022;13:834604
Frontiers in pharmacology 2022;13:834604
Atorvastatin Restores PPARα Inhibition of Lipid Metabolism Disorders by Downregulating miR-21 Expression to Improve Mitochondrial Function and Alleviate Diabetic Nephropathy Progression.
Xiang J, Zhang H, Zhou X, Wang D, Chen R, Tan W, Liang L, Shi M, Zhang F, Xiao Y, Zhou Y, Wang Y, Guo B
Frontiers in pharmacology 2022;13:819787
Frontiers in pharmacology 2022;13:819787
Diallyl Trisulfide Enhances the Survival of Multiterritory Perforator Skin Flaps.
Dong C, Chen Z, Zhu L, Bsoul N, Wu H, Jiang J, Chen X, Lai Y, Yu G, Gu Y, Guo X, Gao W
Frontiers in pharmacology 2022;13:809034
Frontiers in pharmacology 2022;13:809034
Tormentic Acid Ameliorates Hepatic Fibrosis in vivo by Inhibiting Glycerophospholipids Metabolism and PI3K/Akt/mTOR and NF-κB Pathways: Based on Transcriptomics and Metabolomics.
Lin X, Wei Y, Li Y, Xiong Y, Fang B, Li C, Huang Q, Huang R, Wei J
Frontiers in pharmacology 2022;13:801982
Frontiers in pharmacology 2022;13:801982
Long Noncoding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 in Extracellular Vesicles Promotes Hepatic Stellate Cell Activation, Liver Fibrosis and β-Catenin Signaling Pathway.
Wang T, Zhang C, Meng X, Zhu B, Wang S, Yuan W, Zhang S, Xu J, Zhang C
Frontiers in physiology 2022;13:792182
Frontiers in physiology 2022;13:792182
Loss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis.
Christian JI, Pastula A, Herbst A, Neumann J, Marschall MK, Ofner A, Zierahn H, Schneider MR, Wolf E, Quante M, Kolligs FT
Oncotarget 2022;13:615-627
Oncotarget 2022;13:615-627
Yao medicine Amydrium hainanense suppresses hepatic fibrosis by repressing hepatic stellate cell activation via STAT3 signaling.
Wu B, Huang L, Wang Y, Zeng L, Lin Y, Li J, Wang S, Zhang G, An L
Frontiers in pharmacology 2022;13:1043022
Frontiers in pharmacology 2022;13:1043022
Endothelial S1pr2 regulates post-ischemic angiogenesis via AKT/eNOS signaling pathway.
Zhou C, Kuang Y, Li Q, Duan Y, Liu X, Yue J, Chen X, Liu J, Zhang Y, Zhang L
Theranostics 2022;12(11):5172-5188
Theranostics 2022;12(11):5172-5188
Norepinephrine acting on adventitial fibroblasts stimulates vascular smooth muscle cell proliferation via promoting small extracellular vesicle release.
Ye C, Zheng F, Xu T, Wu N, Tong Y, Xiong XQ, Zhou YB, Wang JJ, Chen Q, Li YH, Zhu GQ, Han Y
Theranostics 2022;12(10):4718-4733
Theranostics 2022;12(10):4718-4733
Irradiation enhances the malignancy-promoting behaviors of cancer-associated fibroblasts.
Zhang Z, Dong Y, Wu B, Li Y, Liu Z, Liu Z, Gao Y, Gao L, Song Q, Zheng Z, Yao Y
Frontiers in oncology 2022;12:965660
Frontiers in oncology 2022;12:965660
Fibroblasts mediate the angiogenesis of pheochromocytoma by increasing COX4I2 expression.
Mao Y, Zhuo R, Ma W, Dai J, Alimu P, Fang C, Xu D, Ye L, Wang W, Sun F
Frontiers in oncology 2022;12:938123
Frontiers in oncology 2022;12:938123
Resveratrol ameliorates iron overload induced liver fibrosis in mice by regulating iron homeostasis.
Wang H, Jiang C, Yang Y, Li J, Wang Y, Wang C, Gao Y
PeerJ 2022;10:e13592
PeerJ 2022;10:e13592
Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway.
Sun S, Huan S, Li Z, Yao Y, Su Y, Xia S, Wang S, Xu X, Shao J, Zhang Z, Zhang F, Fu J, Zheng S
PeerJ 2022;10:e13376
PeerJ 2022;10:e13376
From hair to liver: emerging application of hair follicle mesenchymal stem cell transplantation reverses liver cirrhosis by blocking the TGF-β/Smad signaling pathway to inhibit pathological HSC activation.
Liu Q, Lv C, Jiang Y, Luo K, Gao Y, Liu J, Zhang X, Mohammad Omar J, Jin S
PeerJ 2022;10:e12872
PeerJ 2022;10:e12872
Injectable selenium-containing polymeric hydrogel formulation for effective treatment of myocardial infarction.
Yang C, Zhu C, Li Y, Li Z, Zhang Z, Xu J, Chen M, Li R, Liu S, Wu Y, Huang Z, Wu C
Frontiers in bioengineering and biotechnology 2022;10:912562
Frontiers in bioengineering and biotechnology 2022;10:912562
Lycorine Inhibits Hypertrophic Scar Formation by Inducing ROS-Mediated Apoptosis.
Dong Y, Lv D, Zhao Z, Xu Z, Hu Z, Tang B
Frontiers in bioengineering and biotechnology 2022;10:892015
Frontiers in bioengineering and biotechnology 2022;10:892015
Asiaticoside Combined With Carbon Ion Implantation to Improve the Biocompatibility of Silicone Rubber and to Reduce the Risk of Capsule Contracture.
Liu X, Song YJ, Chen X, Huang MY, Zhao CX, Zhou X, Zhou X
Frontiers in bioengineering and biotechnology 2022;10:810244
Frontiers in bioengineering and biotechnology 2022;10:810244
Macrophage derived miR-7219-3p-containing exosomes mediate fibroblast trans-differentiation by targeting SPRY1 in silicosis.
Niu Z, Wang L, Qin X, Ye Z, Xie B, Hu Y
Toxicology 2022 Sep;479:153310
Toxicology 2022 Sep;479:153310
Fatty acid-binding protein 5 aggravates pulmonary artery fibrosis in pulmonary hypertension secondary to left heart disease via activating wnt/β-catenin pathway.
Lei Q, Yu Z, Li H, Cheng J, Wang Y
Journal of advanced research 2022 Sep;40:197-206
Journal of advanced research 2022 Sep;40:197-206
Anti-angiogenic nano-delivery system promotes tumor vascular normalizing and micro-environment reprogramming in solid tumor.
Shen R, Peng L, Zhou W, Wang D, Jiang Q, Ji J, Hu F, Yuan H
Journal of controlled release : official journal of the Controlled Release Society 2022 Sep;349:550-564
Journal of controlled release : official journal of the Controlled Release Society 2022 Sep;349:550-564
Substitution of SERCA2 Cys(674) accelerates aortic aneurysm by inducing endoplasmic reticulum stress and promoting cell apoptosis.
Wang L, Yang Z, Wang S, Que Y, Shu X, Wu F, Liu G, Li S, Hu P, Chen H, Shi J, Tong X
British journal of pharmacology 2022 Sep;179(17):4423-4439
British journal of pharmacology 2022 Sep;179(17):4423-4439
Hydroxyurea protects against diabetic cardiomyopathy by inhibiting inflammation and apoptosis.
Zhou Y, Lu Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113291
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113291
N-Acetyl-l-tryptophan inhibits CCl(4)-induced hepatic fibrogenesis via regulating TGF-β1/SMAD and Hippo/YAP1 signal.
Ma T, Cheng H, Li T, Chen Y, Cai T, Bai J, Wu Z, Xia X, Liang T, Du Y, Fu W
Bioorganic chemistry 2022 Sep;126:105899
Bioorganic chemistry 2022 Sep;126:105899
Immunohistochemical analysis of PD-L1 and tumor-infiltrating immune cells expression in the tumor microenvironment of primary signet ring cell carcinoma of the prostate.
Teng QL, Yang XR, Wen S, Dai ZH, Wang HL, Liu TQ, Wang L, Fan B, Liu ZY
Asian journal of andrology 2022 Sep-Oct;24(5):525-532
Asian journal of andrology 2022 Sep-Oct;24(5):525-532
Metabonomics profile analysis in inflammation-induced preterm birth and the potential role of metabolites in regulating premature cervical ripening.
Yan Y, Gu Z, Li B, Guo X, Zhang Z, Zhang R, Bian Z, Qiu J
Reproductive biology and endocrinology : RB&E 2022 Sep 6;20(1):135
Reproductive biology and endocrinology : RB&E 2022 Sep 6;20(1):135
Alamandine alleviated heart failure and fibrosis in myocardial infarction mice.
Zhao K, Xu T, Mao Y, Wu X, Hua D, Sheng Y, Li P
Biology direct 2022 Sep 27;17(1):25
Biology direct 2022 Sep 27;17(1):25
A dual Keap1 and p47(phox) inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis.
Wang ZC, Niu KM, Wu YJ, Du KR, Qi LW, Zhou YB, Sun HJ
Cell death & disease 2022 Sep 26;13(9):824
Cell death & disease 2022 Sep 26;13(9):824
miR-182-5p attenuates Schistosoma japonicum-induced hepatic fibrosis by targeting tristetraprolin.
Zhao X, Xia Z, Wang Z, Zhou M, Qiu X, Wang C, Xu T, Fang Q, Ming Z, Dong H
Acta biochimica et biophysica Sinica 2022 Sep 25;54(10):1421-1430
Acta biochimica et biophysica Sinica 2022 Sep 25;54(10):1421-1430
Leucine Supplementation in Middle-Aged Male Mice Improved Aging-Induced Vascular Remodeling and Dysfunction via Activating the Sirt1-Foxo1 Axis.
Hao Z, Xu G, Yuan M, Tan R, Xia Y, Liu Y, Yin X
Nutrients 2022 Sep 17;14(18)
Nutrients 2022 Sep 17;14(18)
Cyclodextrin boostered-high density lipoprotein for antiatherosclerosis by regulating cholesterol efflux and efferocytosis.
Wang Y, Gao H, Huang X, Chen Z, Kang P, Zhou Y, Qin D, Zhang W, Liu J
Carbohydrate polymers 2022 Sep 15;292:119632
Carbohydrate polymers 2022 Sep 15;292:119632
Studies of ultrastructure, gene expression, and marker analysis reveal that mouse bladder PDGFRA(+) interstitial cells are fibroblasts.
Clayton DR, Ruiz WG, Dalghi MG, Montalbetti N, Carattino MD, Apodaca G
American journal of physiology. Renal physiology 2022 Sep 1;323(3):F299-F321
American journal of physiology. Renal physiology 2022 Sep 1;323(3):F299-F321
Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production.
Pan D, Wu W, Zuo G, Xie X, Li H, Ren X, Kong C, Zhou W, Zhang Z, Waterfall M, Chen S
Cellular signalling 2022 Oct;98:110419
Cellular signalling 2022 Oct;98:110419
Salt-inducible kinase 1 deficiency promotes vascular remodeling in pulmonary arterial hypertension via enhancement of yes-associated protein-mediated proliferation.
Pu J, Wang F, Ye P, Jiang X, Zhou W, Gu Y, Chen S
Heliyon 2022 Oct;8(10):e11016
Heliyon 2022 Oct;8(10):e11016
Anti-inflammatory potential of stevia residue extract against uric acid-associated renal injury in mice.
Mehmood A, Althobaiti F, Zhao L, Usman M, Chen X, Alharthi F, Soliman MM, Shah AA, Murtaza MA, Nadeem M, Ranjha MMAN, Wang C
Journal of food biochemistry 2022 Oct;46(10):e14286
Journal of food biochemistry 2022 Oct;46(10):e14286
Activating α7nAChR ameliorates abdominal aortic aneurysm through inhibiting pyroptosis mediated by NLRP3 inflammasome.
Fu H, Shen QR, Zhao Y, Ni M, Zhou CC, Chen JK, Chi C, Li DJ, Liang G, Shen FM
Acta pharmacologica Sinica 2022 Oct;43(10):2585-2595
Acta pharmacologica Sinica 2022 Oct;43(10):2585-2595
UFMylation Is Activated in Atherosclerosis of ApoE Knockout Mice.
Sun Y, Li W, Cao Z, Hu J, Jia M, Su M
DNA and cell biology 2022 Oct;41(10):871-878
DNA and cell biology 2022 Oct;41(10):871-878
Substitution of the SERCA2 Cys(674) reactive thiol accelerates atherosclerosis by inducing endoplasmic reticulum stress and inflammation.
Su H, Mei Y, Luo S, Wu H, He Y, Shiraishi Y, Hu P, Cohen RA, Tong X
British journal of pharmacology 2022 Oct;179(20):4778-4791
British journal of pharmacology 2022 Oct;179(20):4778-4791
Induction of GLI1 by miR-27b-3p/FBXW7/KLF5 pathway contributes to pulmonary arterial hypertension.
Wang Q, Chai L, Zhang Q, Wang J, Liu J, Chen H, Wang Y, Chen Y, Shen N, Xie X, Li M
Journal of molecular and cellular cardiology 2022 Oct;171:16-29
Journal of molecular and cellular cardiology 2022 Oct;171:16-29
Established new compound IMB16-4 self-emulsifying drug delivery systems for increasing oral bioavailability and enhancing anti-hepatic fibrosis effect.
Niu X, Meng Y, Wang Y, Li G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113657
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113657
CREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment.
Pan Z, Xu T, Bao L, Hu X, Jin T, Chen J, Chen J, Qian Y, Lu X, Li L, Zheng G, Zhang Y, Zou X, Song F, Zheng C, Jiang L, Wang J, Tan Z, Huang P, Ge M
Molecular cancer 2022 Oct 3;21(1):190
Molecular cancer 2022 Oct 3;21(1):190
A network pharmacology-based study on the mechanism of astragaloside IV alleviating renal fibrosis through the AKT1/GSK-3β pathway.
Yu X, Xiao Q, Yu X, Cheng Y, Lin H, Xiang Z
Journal of ethnopharmacology 2022 Oct 28;297:115535
Journal of ethnopharmacology 2022 Oct 28;297:115535
Vascular restenosis reduction with platelet membrane coated nanoparticle directed M2 macrophage polarization.
Li F, Rong Z, Zhang R, Niu S, Di X, Ni L, Liu C
iScience 2022 Oct 21;25(10):105147
iScience 2022 Oct 21;25(10):105147
Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and ameliorates organ fibrosis.
Wang L, Zhang Y, Ren Y, Yang X, Ben H, Zhao F, Yang S, Wang L, Qing J
European journal of pharmacology 2022 Oct 15;932:175241
European journal of pharmacology 2022 Oct 15;932:175241
Single-cell RNA-seq analysis of testicular somatic cell development in pigs.
Zhang L, Guo M, Liu Z, Liu R, Zheng Y, Yu T, Lv Y, Lu H, Zeng W, Zhang T, Pan C
Journal of genetics and genomics = Yi chuan xue bao 2022 Nov;49(11):1016-1028
Journal of genetics and genomics = Yi chuan xue bao 2022 Nov;49(11):1016-1028
Cancer-associated fibroblast-secreted miR-421 promotes pancreatic cancer by regulating the SIRT3/H3K9Ac/HIF-1α axis.
Zhou B, Lei JH, Wang Q, Qu TF, Cha LC, Zhan HX, Liu SL, Hu X, Sun CD, Guo WD, Qiu FB, Cao JY
The Kaohsiung journal of medical sciences 2022 Nov;38(11):1080-1092
The Kaohsiung journal of medical sciences 2022 Nov;38(11):1080-1092
Biomimetic cell membrane-coated glucose/oxygen-exhausting nanoreactor for remodeling tumor microenvironment in targeted hypoxic tumor therapy.
Guo H, Zhang W, Wang L, Shao Z, Huang X
Biomaterials 2022 Nov;290:121821
Biomaterials 2022 Nov;290:121821
Apigenin inhibits fibrous scar formation after acute spinal cord injury through TGFβ/SMADs signaling pathway.
Jin Z, Tian L, Zhang Y, Zhang X, Kang J, Dong H, Huang N, Pan L, Ning B
CNS neuroscience & therapeutics 2022 Nov;28(11):1883-1894
CNS neuroscience & therapeutics 2022 Nov;28(11):1883-1894
Apatinib Through Activating the RhoA/ROCK Signaling Pathway to Cause Dysfunction of Vascular Smooth Muscle Cells.
Wang W, He Q, Zhuang C, Zhang H, Fan X, Wang Q, Qi M, Sun R, Li C, Yu J
Applied biochemistry and biotechnology 2022 Nov;194(11):5367-5385
Applied biochemistry and biotechnology 2022 Nov;194(11):5367-5385
Extracellular vesicles from human urine-derived stem cells merged in hyaluronic acid ameliorate erectile dysfunction in type 2 diabetic rats by glans administration.
Zhuang J, Gao P, Chen H, Fang Z, Zheng J, Zhu D, Hou J
Andrology 2022 Nov;10(8):1673-1686
Andrology 2022 Nov;10(8):1673-1686
Aligned nanofibrous collagen membranes from fish swim bladder as a tough and acid-resistant suture for pH-regulated stomach perforation and tendon rupture.
Luan Z, Liu S, Wang W, Xu K, Ye S, Dan R, Zhang H, Shu Z, Wang T, Fan C, Xing M, Yang S
Biomaterials research 2022 Nov 8;26(1):60
Biomaterials research 2022 Nov 8;26(1):60
Pirfenidone-loaded exosomes derived from pancreatic ductal adenocarcinoma cells alleviate fibrosis of premetastatic niches to inhibit liver metastasis.
Zhao J, Zhu Y, Li Z, Liang J, Zhang Y, Zhou S, Zhang Y, Fan Z, Shen Y, Liu Y, Zhang F, Shen S, Xu G, Wang L, Lv Y, Zhang S, Zou X
Biomaterials science 2022 Nov 8;10(22):6614-6626
Biomaterials science 2022 Nov 8;10(22):6614-6626
The Impact of Sleep Disturbance on Gut Microbiota, Atrial Substrate, and Atrial Fibrillation Inducibility in Mice: A Multi-Omics Analysis.
Zuo K, Fang C, Fu Y, Liu Z, Liu Y, Liu L, Wang Y, Wang H, Yin X, Liu X, Li J, Zhong J, Chen M, Yang X, Xu L
Metabolites 2022 Nov 20;12(11)
Metabolites 2022 Nov 20;12(11)
Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis.
Ling X, Lu J, Wang X, Liu L, Liu L, Wang Y, Sun Y, Ren C, Lu C, Yu Z
iScience 2022 Nov 18;25(11):105363
iScience 2022 Nov 18;25(11):105363
A Shape-Adaptive Gallic Acid Driven Multifunctional Adhesive Hydrogel Loaded with Scolopin2 for Wound Repair.
Chen H, Zheng T, Wu C, Wang J, Ye F, Cui M, Sun S, Zhang Y, Li Y, Dong Z
Pharmaceuticals (Basel, Switzerland) 2022 Nov 17;15(11)
Pharmaceuticals (Basel, Switzerland) 2022 Nov 17;15(11)
Ultrastructural Characterization of Human Gingival Fibroblasts in 3D Culture.
Alfonso García SL, Mira Uribe LM, Castaño López S, Parada-Sanchez MT, Arboleda-Toro D
Cells 2022 Nov 17;11(22)
Cells 2022 Nov 17;11(22)
LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis.
Peng T, Liu M, Hu L, Guo D, Wang D, Qi B, Ren G, Hu C, Zhang F, Chun HJ, Song L, Hu J, Li Y
Biology direct 2022 Nov 16;17(1):32
Biology direct 2022 Nov 16;17(1):32
Targeting glutamine metabolism in hepatic stellate cells alleviates liver fibrosis.
Yin X, Peng J, Gu L, Liu Y, Li X, Wu J, Xu B, Zhuge Y, Zhang F
Cell death & disease 2022 Nov 14;13(11):955
Cell death & disease 2022 Nov 14;13(11):955
S100A8-Mediated NLRP3 Inflammasome-Dependent Pyroptosis in Macrophages Facilitates Liver Fibrosis Progression.
Liu Y, Kong X, You Y, Xiang L, Zhang Y, Wu R, Zhou L, Duan L
Cells 2022 Nov 12;11(22)
Cells 2022 Nov 12;11(22)
Disulfiram ameliorates nonalcoholic steatohepatitis by modulating the gut microbiota and bile acid metabolism.
Lei Y, Tang L, Chen Q, Wu L, He W, Tu D, Wang S, Chen Y, Liu S, Xie Z, Wei H, Yang S, Tang B
Nature communications 2022 Nov 11;13(1):6862
Nature communications 2022 Nov 11;13(1):6862
NLRC3 deficiency promotes cutaneous wound healing due to the inhibition of p53 signaling.
Qin Y, Wu K, Zhang Z, Pan R, Lin Z, Zhang W, Huang S, Dai J, Huang R, Gong S, Lin H, Chong S, Lu L, Lu X
Biochimica et biophysica acta. Molecular basis of disease 2022 Nov 1;1868(11):166518
Biochimica et biophysica acta. Molecular basis of disease 2022 Nov 1;1868(11):166518
PEDF reduces malignant cells proliferation and inhibits the progression of myelofibrosis in myeloproliferative neoplasms.
Li Y, Gao H, Dong H, Wang W, Xu Z, Wang G, Liu Y, Wang H, Ju W, Qiao J, Xu K, Fu C, Zeng L
Biochemical pharmacology 2022 May;199:115013
Biochemical pharmacology 2022 May;199:115013
Sphk1 and Sphk2 Differentially Regulate Erythropoietin Synthesis in Mouse Renal Interstitial Fibroblast-like Cells.
Hafizi R, Imeri F, Stepanovska Tanturovska B, Manaila R, Schwalm S, Trautmann S, Wenger RH, Pfeilschifter J, Huwiler A
International journal of molecular sciences 2022 May 24;23(11)
International journal of molecular sciences 2022 May 24;23(11)
Cancer associated fibroblast-derived CCL5 promotes hepatocellular carcinoma metastasis through activating HIF1α/ZEB1 axis.
Xu H, Zhao J, Li J, Zhu Z, Cui Z, Liu R, Lu R, Yao Z, Xu Q
Cell death & disease 2022 May 20;13(5):478
Cell death & disease 2022 May 20;13(5):478
Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway.
Shen R, Yang K, Cheng X, Guo C, Xing X, Sun H, Liu D, Liu X, Wang D
Environmental pollution (Barking, Essex : 1987) 2022 May 1;300:118986
Environmental pollution (Barking, Essex : 1987) 2022 May 1;300:118986
Development and identification of a induced pluripotent stem cells line (SMBCi013-A) derived from urine cells of a patient with Wilson's disease.
Zhao Y, Cui Y, Luan J, Wang J, Shi L, Han Z, Han J
Stem cell research 2022 Mar;59:102650
Stem cell research 2022 Mar;59:102650
Kinsenoside attenuates liver fibro-inflammation by suppressing dendritic cells via the PI3K-AKT-FoxO1 pathway.
Xiang M, Liu T, Tian C, Ma K, Gou J, Huang R, Li S, Li Q, Xu C, Li L, Lee CH, Zhang Y
Pharmacological research 2022 Mar;177:106092
Pharmacological research 2022 Mar;177:106092
MicroRNA-130a attenuates cardiac fibrosis after myocardial infarction through TGF-β/Smad signaling by directly targeting TGF-β receptor 1.
Feng Y, Bao Y, Ding J, Li H, Liu W, Wang X, Guan H, Chen Z
Bioengineered 2022 Mar;13(3):5779-5791
Bioengineered 2022 Mar;13(3):5779-5791
P16ink4a overexpression ameliorates cardiac remodeling of mouse following myocardial infarction via CDK4/pRb pathway.
Shi J, Sun J, Liu L, Shan T, Meng H, Yang T, Wang S, Wei T, Chen B, Ma Y, Wang Q, Wang H, Liu J, Wang L
Biochemical and biophysical research communications 2022 Mar 5;595:62-68
Biochemical and biophysical research communications 2022 Mar 5;595:62-68
The SETD8/ELK1/bach1 complex regulates hyperglycaemia-mediated EndMT in diabetic nephropathy.
Li X, Lu L, Hou W, Wang F, Huang T, Meng Z, Zhu M
Journal of translational medicine 2022 Mar 29;20(1):147
Journal of translational medicine 2022 Mar 29;20(1):147
Ferroptosis, a new target for treatment of renal injury and fibrosis in a 5/6 nephrectomy-induced CKD rat model.
Wang J, Wang Y, Liu Y, Cai X, Huang X, Fu W, Wang L, Qiu L, Li J, Sun L
Cell death discovery 2022 Mar 22;8(1):127
Cell death discovery 2022 Mar 22;8(1):127
Exosomal let-7i-5p from three-dimensional cultured human umbilical cord mesenchymal stem cells inhibits fibroblast activation in silicosis through targeting TGFBR1.
Xu C, Hou L, Zhao J, Wang Y, Jiang F, Jiang Q, Zhu Z, Tian L
Ecotoxicology and environmental safety 2022 Mar 15;233:113302
Ecotoxicology and environmental safety 2022 Mar 15;233:113302
Knockdown of long noncoding RNA MIAT attenuates cigarette smoke-induced airway remodeling by downregulating miR-29c-3p-HIF3A axis.
Gu W, Wang L, Deng G, Gu X, Tang Z, Li S, Jin W, Yang J, Guo X, Li Q
Toxicology letters 2022 Mar 1;357:11-19
Toxicology letters 2022 Mar 1;357:11-19
Citri Reticulatae Pericarpium alleviates postmyocardial infarction heart failure by upregulating PPARγ expression.
Chen M, Zhu H, Zhu Q, Wu X, Zhou Y, Gao R, Shi M, Zhang T, Yin T, Zhang H, Shang H, Li X
Clinical and experimental pharmacology & physiology 2022 Jun;49(6):661-673
Clinical and experimental pharmacology & physiology 2022 Jun;49(6):661-673
Modification of lysine deacetylation regulates curcumol-induced necroptosis through autophagy in hepatic stellate cells.
Sun S, Li Z, Huan S, Kai J, Xia S, Su Y, Ji S, Chen A, Wang S, Xu X, Shao J, Zhang F, Zhang B, Zhang Z, Zheng S
Phytotherapy research : PTR 2022 Jun;36(6):2660-2676
Phytotherapy research : PTR 2022 Jun;36(6):2660-2676
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
Wang Y, Jin C, Tian H, Xu J, Chen J, Hu S, Li Q, Lu L, Ou Q, Xu GT, Cui H
Experimental eye research 2022 Jun;219:108939
Experimental eye research 2022 Jun;219:108939
Gli(ko) BMSC: A potential strategy of treatment for renal fibrosis.
Shi L, Gao X, Bi Y, Li M, Sun H, Tian X, Bi W
Regenerative therapy 2022 Jun;20:157-164
Regenerative therapy 2022 Jun;20:157-164
Myelin-associated glycoprotein combined with chitin conduit inhibits painful neuroma formation after sciatic nerve transection.
Pi W, Li C, Zhang M, Zhang W, Zhang PX
Neural regeneration research 2022 Jun;17(6):1343-1347
Neural regeneration research 2022 Jun;17(6):1343-1347
Tracking the response to Pseudomonas aeruginosa infection in ozone-induced chronic obstructive pulmonary disease mouse models.
Han L, Huang Y, Fu Q, Xue Y, Ding F, Zhang M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jun;150:112980
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jun;150:112980
Molecular feature of arterial remodeling in the brain arteriovenous malformation revealed by arteriovenous shunt rat model and RNA sequencing.
Chen B, Tao W, Yan L, Zeng M, Song L, Huang Z, Chen F
International immunopharmacology 2022 Jun;107:108653
International immunopharmacology 2022 Jun;107:108653
Targeted inhibition of the immunoproteasome blocks endothelial MHC class II antigen presentation to CD4(+) T cells in chronic liver injury.
Zhang Y, Yang X, Bi T, Wu X, Wang L, Ren Y, Ou Y, Xie C, Li K, Ran H, Wang J, Zhao F, Shui P, Qing J
International immunopharmacology 2022 Jun;107:108639
International immunopharmacology 2022 Jun;107:108639
Capsaicin ameliorates renal fibrosis by inhibiting TGF-β1-Smad2/3 signaling.
Liu Z, Wang W, Li X, Tang S, Meng D, Xia W, Wang H, Wu Y, Zhou X, Zhang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154067
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154067
Hydroxychloroquine alleviates renal interstitial fibrosis by inhibiting the PI3K/Akt signaling pathway.
Li D, Yu K, Feng F, Zhang Y, Bai F, Zhang Y, Sun N, Fan J, Liu L, Yang H, Yang X
Biochemical and biophysical research communications 2022 Jun 25;610:154-161
Biochemical and biophysical research communications 2022 Jun 25;610:154-161
Erectile dysfunction in hypospadiac male adult rats induced by maternal exposure to di-n-butyl phthalate.
Zhou X, Wang S, Zhou R, Zhang T, Wang Y, Zhang Q, Cong R, Ji C, Luan J, Yao L, Zhou X, Song N
Toxicology 2022 Jun 15;475:153227
Toxicology 2022 Jun 15;475:153227
CUX1 promotes epithelial-mesenchymal transition (EMT) in renal fibrosis of UUO model by targeting MMP7.
Teng S, Liu G, Li L, Ou J, Yu Y
Biochemical and biophysical research communications 2022 Jun 11;608:128-134
Biochemical and biophysical research communications 2022 Jun 11;608:128-134
Spermidine Ameliorates Nonalcoholic Steatohepatitis through Thyroid Hormone-Responsive Protein Signaling and the Gut Microbiota-Mediated Metabolism of Bile Acids.
Ni Y, Hu Y, Lou X, Rong N, Liu F, Yang C, Zheng A, Yang S, Bao J, Fu Z
Journal of agricultural and food chemistry 2022 Jun 1;70(21):6478-6492
Journal of agricultural and food chemistry 2022 Jun 1;70(21):6478-6492
Generation of a non-integrated induced pluripotent stem cell line from urine cells of a Chinese osteogenesis imperfecta type I patient.
Luan J, Cui Y, Wang J, Liang Y, Zhao Y, Zhang G, Han J
Stem cell research 2022 Jul;62:102827
Stem cell research 2022 Jul;62:102827
Generation of induced pluripotent stem cells named SMBCi019-A from a methylmalonic acidemia patient carrying the MMACHC mutations.
Luan J, Zou H, Cui Y, Wang J, Han Z, Zhang G, Han J
Stem cell research 2022 Jul;62:102821
Stem cell research 2022 Jul;62:102821
Establishment of a control induced pluripotent stem cell line SMBCi018-A from a patient with congenital talipes equinovarus.
Han Z, Wang J, Luan J, Cui Y, Han J
Stem cell research 2022 Jul;62:102814
Stem cell research 2022 Jul;62:102814
LncRNA LINC00961 regulates endothelial‑mesenchymal transition via the PTEN‑PI3K‑AKT pathway.
Hu JX, Zheng ZQ, Kang T, Qian W, Huang SH, Li BG
Molecular medicine reports 2022 Jul;26(1)
Molecular medicine reports 2022 Jul;26(1)
Asperuloside inhibited epithelial-mesenchymal transition in colitis associated cancer via activation of vitamin D receptor.
Lu Y, Guan T, Xu S, Chen YE, Shen Q, Zhu S, Liu Y, Liang J, Hou S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul;101:154070
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul;101:154070
Peptidome analysis of human intrauterine adhesion tissues and the identification of antifibrotic peptide.
Hua X, Zhang Y, Xu J, Xu L, Shi Y, Yang D, Gu X, Wang S, Jia X, Xu F, Chen J, Ying X
Journal of biomedical research 2022 Jul 28;36(4):280-296
Journal of biomedical research 2022 Jul 28;36(4):280-296
Albumin-induced premature senescence in human renal proximal tubular cells and its relationship with intercellular fibrosis.
Lu W, Ren S, Dong W, Li X, Zheng Z, Jia Y, Xue Y
Acta biochimica et biophysica Sinica 2022 Jul 25;54(7):893-903
Acta biochimica et biophysica Sinica 2022 Jul 25;54(7):893-903
Nintedanib Inhibits Endothelial Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis via Focal Adhesion Kinase Activity Reduction.
Yu WK, Chen WC, Su VY, Shen HC, Wu HH, Chen H, Yang KY
International journal of molecular sciences 2022 Jul 25;23(15)
International journal of molecular sciences 2022 Jul 25;23(15)
Interplay of Helicobacter pylori, fibroblasts, and cancer cells induces fibroblast activation and serpin E1 expression by cancer cells to promote gastric tumorigenesis.
Chen X, Chen W, Zhao Y, Wang Q, Wang W, Xiang Y, Yuan H, Xie Y, Zhou J
Journal of translational medicine 2022 Jul 21;20(1):322
Journal of translational medicine 2022 Jul 21;20(1):322
Identification of the active compounds and functional mechanisms of Jinshui Huanxian formula in pulmonary fibrosis by integrating serum pharmacochemistry with network pharmacology.
Shao D, Liu X, Wu J, Zhang A, Bai Y, Zhao P, Li J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul 20;102:154177
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul 20;102:154177
Bmp7 drives proximal tubule expansion and determines nephron number in the developing kidney.
Taglienti M, Graf D, Schumacher V, Kreidberg JA
Development (Cambridge, England) 2022 Jul 15;149(14)
Development (Cambridge, England) 2022 Jul 15;149(14)
BMSC-derived exosomes protect against kidney injury through regulating klotho in 5/6 nephrectomy rats.
Wan F, Yang RC, Tang YW, Tang XL, Ye T, Zheng J, Zhang HQ, Lin Y
European journal of medical research 2022 Jul 11;27(1):118
European journal of medical research 2022 Jul 11;27(1):118
Monochromatic blue light not green light exposure is associated with continuous light-induced hepatic steatosis in high fat diet fed-mice via oxidative stress.
Guan Q, Wang Z, Cao J, Dong Y, Chen Y
Ecotoxicology and environmental safety 2022 Jul 1;239:113625
Ecotoxicology and environmental safety 2022 Jul 1;239:113625
The DR1‑CSE/H(2)S system inhibits renal fibrosis by downregulating the ERK1/2 signaling pathway in diabetic mice.
Li H, Sun F, Bai S, Chang G, Wu R, Wei Y, Wen X, Xi Y, Hao J, Zaid A
International journal of molecular medicine 2022 Jan;49(1)
International journal of molecular medicine 2022 Jan;49(1)
Histone methyltransferase DOT1L mediates the TGF-β1/Smad3 signaling pathway through epigenetic modification of SYK in myocardial infarction.
Li F, Li L, Zhang J, Yang X, Liu Y
Human cell 2022 Jan;35(1):98-110
Human cell 2022 Jan;35(1):98-110
Jolkinolide B alleviates renal fibrosis via anti-inflammation and inhibition of epithelial-mesenchymal transition in unilateral ureteral obstruction mice.
Li M, Yan Y, He J, Wang YM, Guo YX, Wang ZX, Zhang WK, Zhang HJ, Xu JK
Journal of Asian natural products research 2022 Jan;24(1):76-87
Journal of Asian natural products research 2022 Jan;24(1):76-87
Isolation and characterization of secondary metabolites from the leaves of Sauropus spatulifolius Beille and their potential biological assays.
Li M, Cui Y, Zhu M, Huang X, Rehman FU, Wang J, Zhang L, Liu T, Liu J, Lu J, Jiang X, Zhang J
Fitoterapia 2022 Jan;156:105100
Fitoterapia 2022 Jan;156:105100
Endothelial cell metabolic memory causes cardiovascular dysfunction in diabetes.
Yao Y, Song Q, Hu C, Da X, Yu Y, He Z, Xu C, Chen Q, Wang QK
Cardiovascular research 2022 Jan 7;118(1):196-211
Cardiovascular research 2022 Jan 7;118(1):196-211
N6-Methyladenosine Modification of CDH1 mRNA Promotes PM2.5-Induced Pulmonary Fibrosis via Mediating Epithelial Mesenchymal Transition.
Ning J, Du H, Zhang Y, Liu Q, Jiang T, Pang Y, Tian X, Yan L, Niu Y, Zhang R
Toxicological sciences : an official journal of the Society of Toxicology 2022 Jan 24;185(2):143-157
Toxicological sciences : an official journal of the Society of Toxicology 2022 Jan 24;185(2):143-157
ZC3H4 promotes pulmonary fibrosis via an ER stress-related positive feedback loop.
Ghafoor H, Chu H, Huang J, Chen M, Wang S, Wang J, Chao J
Toxicology and applied pharmacology 2022 Jan 15;435:115856
Toxicology and applied pharmacology 2022 Jan 15;435:115856
New IMB16-4 Nanoparticles Improved Oral Bioavailability and Enhanced Anti-Hepatic Fibrosis on Rats.
Niu X, Wang X, Niu B, Wang Y, He H, Li G
Pharmaceuticals (Basel, Switzerland) 2022 Jan 11;15(1)
Pharmaceuticals (Basel, Switzerland) 2022 Jan 11;15(1)
Uncaria Rhynchophylla attenuates angiotensin Ⅱ-induced myocardial fibrosis via suppression of the RhoA/ROCK1 pathway.
Xie L, Wang T, Lin S, Lu Z, Wang Y, Shen Z, Cheng Y, Shen A, Peng J, Chu J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Feb;146:112607
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Feb;146:112607
One-Step Synthesis of Multifunctional Chitosan Hydrogel for Full-Thickness Wound Closure and Healing.
Guo S, Yao M, Zhang D, He Y, Chang R, Ren Y, Guan F
Advanced healthcare materials 2022 Feb;11(4):e2101808
Advanced healthcare materials 2022 Feb;11(4):e2101808
Remodeling Chondroitin-6-Sulfate-Mediated Immune Exclusion Enhances Anti-PD-1 Response in Colorectal Cancer with Microsatellite Stability.
Wu Q, Huang Q, Jiang Y, Sun F, Liang B, Wang J, Hu X, Sun M, Ma Z, Shi Y, Liang Y, Tan Y, Zeng D, Yao F, Xu X, Yao Z, Li S, Rong X, Huang N, Sun L, Liao W, Shi M
Cancer immunology research 2022 Feb;10(2):182-199
Cancer immunology research 2022 Feb;10(2):182-199
TiO(2) nanosheets promote the transformation of vascular smooth muscle cells into foam cells in vitro and in vivo through the up-regulation of nuclear factor kappa B subunit 2.
Li S, Yan D, Huang C, Yang F, Cao Y
Journal of hazardous materials 2022 Feb 15;424(Pt D):127704
Journal of hazardous materials 2022 Feb 15;424(Pt D):127704
Necroptosis in pulmonary macrophages promotes silica-induced inflammation and interstitial fibrosis in mice.
Tao H, Zhao H, Ge D, Liao J, Shao L, Mo A, Hu L, Xu K, Wu J, Mu M, Li B, Tao X, Wang J
Toxicology letters 2022 Feb 1;355:150-159
Toxicology letters 2022 Feb 1;355:150-159
IL13 and periostin in active fibrogenic areas of the extrahepatic bile ducts in biliary atresia patients.
Sengoku Y, Higashi M, Nagayabu K, Takayama S, Fumino S, Aoi S, Furukawa T, Tajiri T
Pediatric surgery international 2022 Dec;38(12):1847-1853
Pediatric surgery international 2022 Dec;38(12):1847-1853
A comprehensive analysis on the relationship between BDE-209 exposure and erectile dysfunction.
Zhou X, Song L, Cong R, Luan J, Zhou X, Wang Y, Yao L, Zhang X, Ren X, Zhang T, Yu M, Song N
Chemosphere 2022 Dec;308(Pt 3):136486
Chemosphere 2022 Dec;308(Pt 3):136486
Branched-chain amino acid transaminase 1 inhibition attenuates childhood asthma in mice by effecting airway remodeling and autophagy.
Li J, Chen M, Lu L, Wang J, Tan L
Respiratory physiology & neurobiology 2022 Dec;306:103961
Respiratory physiology & neurobiology 2022 Dec;306:103961
Poly I:C Exacerbates Airway Inflammation and Remodeling in Cigarette Smoke-Exposed Mice.
Mei X, Lu R, Cui L, Tian Y, Zhao P, Li J
Lung 2022 Dec;200(6):677-686
Lung 2022 Dec;200(6):677-686
Multifunctional Silk Fibroin Methacryloyl Microneedle for Diabetic Wound Healing.
Guan G, Zhang Q, Jiang Z, Liu J, Wan J, Jin P, Lv Q
Small (Weinheim an der Bergstrasse, Germany) 2022 Dec;18(51):e2203064
Small (Weinheim an der Bergstrasse, Germany) 2022 Dec;18(51):e2203064
Deletion of SIRT6 in vascular smooth muscle cells facilitates vascular calcification via suppression of DNA damage repair.
Wang S, Li L, Liang Q, Ye Y, Lan Z, Dong Q, Chen A, Fu M, Li Y, Liu X, Ou JS, Lu L, Yan J
Journal of molecular and cellular cardiology 2022 Dec;173:154-168
Journal of molecular and cellular cardiology 2022 Dec;173:154-168
IL-8 exacerbates CCl(4)-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway.
Ma Y, Bao Y, Wu L, Ke Y, Tan L, Ren H, Song J, Zhang Q, Jin Y
Molecular immunology 2022 Dec;152:111-122
Molecular immunology 2022 Dec;152:111-122
PVT1/miR-145-5p/HK2 modulates vascular smooth muscle cells phenotype switch via glycolysis: The new perspective on the spiral artery remodeling.
Wu M, Liu W, Huang H, Chen Z, Chen Y, Zhong Y, Jin Z, Liu X, Zou L
Placenta 2022 Dec;130:25-33
Placenta 2022 Dec;130:25-33
Inhibition of glutamine transporter ASCT2 mitigates bleomycin-induced pulmonary fibrosis in mice.
Lian N, Jin H, Zhu W, Zhang C, Qi Y, Jiang M, Mao J, Lu X, Zhao F, Xi B, Qi X, Li Y
Acta histochemica 2022 Dec;124(8):151961
Acta histochemica 2022 Dec;124(8):151961
Bempedoic acid, an ATP citrate lyase inhibitor, reduces intimal hyperplasia via activation of AMPKα signaling pathway.
Liu W, Liu M, Xiong H, Xia L, Yang Q, Chen M, Cai Y, Li S
International immunopharmacology 2022 Dec;113(Pt A):109392
International immunopharmacology 2022 Dec;113(Pt A):109392
A multifunctional black phosphorus-based adhesive patch intrinsically induces partial EMT for effective burn wound healing.
Wang X, Tang X, Li N, Sun Y, Yu R, Zhang J, Li D, Yang B, Sun H
Biomaterials science 2022 Dec 20;11(1):235-247
Biomaterials science 2022 Dec 20;11(1):235-247
The Influence of Novel, Biocompatible, and Bioresorbable Poly(3-hydroxyoctanoate) Dressings on Wound Healing in Mice.
Seta M, Haraźna K, Kasarełło K, Solarz-Keller D, Cudnoch-Jędrzejewska A, Witko T, Rajfur Z, Guzik M
International journal of molecular sciences 2022 Dec 18;23(24)
International journal of molecular sciences 2022 Dec 18;23(24)
Overexpressed DDX3x promotes abdominal aortic aneurysm formation and activates AKT in ApoE knockout mice.
Zhou Y, Chai H, Hu Y, Liu R, Jiang H, Fan R, Chen W, Chen X, Huang F
Biochemical and biophysical research communications 2022 Dec 17;634:138-144
Biochemical and biophysical research communications 2022 Dec 17;634:138-144
Insights into the mechanism underlying crystalline silica-induced pulmonary fibrosis via transcriptome-wide m(6)A methylation profile.
Zhang Y, Gu P, Xie Y, Fan L, You X, Yang S, Yao Y, Chen W, Ma J
Ecotoxicology and environmental safety 2022 Dec 1;247:114215
Ecotoxicology and environmental safety 2022 Dec 1;247:114215
Development of a human iPSC line (SMBCi017-A) from a healthy donor.
Han Z, Wang J, Luan J, Cui Y, Han J
Stem cell research 2022 Aug;63:102852
Stem cell research 2022 Aug;63:102852
Use of wogonin as a cooperative drug with praziquantel to better combat schistosomiasis.
Pekkle Lam HY, Hung MY, Cheng PC, Peng SY
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2022 Aug;55(4):757-765
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2022 Aug;55(4):757-765
Long noncoding RNA GAS5 inhibits LX-2 cells activation by suppressing NF-κB signalling through regulation of the miR-433-3p/TLR10 axis.
Su SB, Tao L, Liang XL, Chen W
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2022 Aug;54(8):1066-1075
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2022 Aug;54(8):1066-1075
Riboflavin deficiency leads to irreversible cellular changes in the RPE and disrupts retinal function through alterations in cellular metabolic homeostasis.
Sinha T, Ikelle L, Makia MS, Crane R, Zhao X, Kakakhel M, Al-Ubaidi MR, Naash MI
Redox biology 2022 Aug;54:102375
Redox biology 2022 Aug;54:102375
Corn oligopeptides inhibit Akt/NF-κB signaling pathway and inflammatory factors to ameliorate CCl(4) -induced hepatic fibrosis in mice.
Feng XW, Cheng QL, Fang L, Liu WY, Liu LW, Sun CQ, Lu ZH, Li GM, Gu RZ
Journal of food biochemistry 2022 Aug;46(8):e14162
Journal of food biochemistry 2022 Aug;46(8):e14162
Construction and identification of an immortalized rat intestinal smooth muscle cell line.
Chen H, Li X, Gao L, Zhang D, Han T
Neurogastroenterology and motility 2022 Aug;34(8):e14359
Neurogastroenterology and motility 2022 Aug;34(8):e14359
Curcumin attenuates vascular calcification via the exosomal miR-92b-3p/KLF4 axis.
Chen C, Li Y, Lu H, Liu K, Jiang W, Zhang Z, Qin X
Experimental biology and medicine (Maywood, N.J.) 2022 Aug;247(16):1420-1432
Experimental biology and medicine (Maywood, N.J.) 2022 Aug;247(16):1420-1432
FXR deficiency in hepatocytes disrupts the bile acid homeostasis and inhibits autophagy to promote liver injury in Schistosoma japonicum-infected mice.
Zhang B, Li J, Zong X, Wang J, Xin L, Song H, Zhang W, Koda S, Hua H, Zhang B, Yu Q, Zheng KY, Yan C
PLoS neglected tropical diseases 2022 Aug;16(8):e0010651
PLoS neglected tropical diseases 2022 Aug;16(8):e0010651
LncRNA SNHG11 promotes the malignant transformation of human bronchial epithelial cells induced by beryllium sulfate.
Deng W, Sun Z, Chen S, Li G, Liu X, Huang L, Zhang Z
Toxicology research 2022 Aug;11(4):605-615
Toxicology research 2022 Aug;11(4):605-615
Morroniside, a novel GATA3 binding molecule, inhibits hepatic stellate cells activation by enhancing lysosomal acid lipase expression.
An L, Zhang M, Lin Y, Jiang T, Xu K, Xiao S, Cai L, Kwan HY, Liu Z, Su T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Aug;103:154199
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Aug;103:154199
Circ_0047339 promotes the activation of fibroblasts and affects the development of urethral stricture by targeting the miR-4691-5p/TSP-1 axis.
Ding K, Li D, Zhang R, Zuo M
Scientific reports 2022 Aug 30;12(1):14746
Scientific reports 2022 Aug 30;12(1):14746
Integrated single-cell transcriptomics and proteomics reveal cellular-specific responses and microenvironment remodeling in aristolochic acid nephropathy.
Chen J, Luo P, Wang C, Yang C, Bai Y, He X, Zhang Q, Zhang J, Yang J, Wang S, Wang J
JCI insight 2022 Aug 22;7(16)
JCI insight 2022 Aug 22;7(16)
Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy.
Sun X, Yang Y, Sun X, Meng H, Hao W, Yin J, Ma F, Guo X, Du L, Sun L, Wu H
Journal of agricultural and food chemistry 2022 Aug 17;70(32):9865-9876
Journal of agricultural and food chemistry 2022 Aug 17;70(32):9865-9876
ZC3H4 regulates infiltrating monocytes, attenuating pulmonary fibrosis through IL-10.
Liu Y, Zhang X, Wang J, Yang F, Luo W, Huang J, Chen M, Wang S, Li C, Zhang W, Chao J
Respiratory research 2022 Aug 12;23(1):204
Respiratory research 2022 Aug 12;23(1):204
Antifibrotic and anthelminthic effect of casticin on Schistosoma mansoni-infected BALB/c mice.
Lam HYP, Liang TR, Lan YC, Chang KC, Cheng PC, Peng SY
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2022 Apr;55(2):314-322
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 2022 Apr;55(2):314-322
Resolution of systemic complications in Schistosoma mansoni-infected mice by concomitant treatment with praziquantel and Schisandrin B.
Lam HYP, Cheng PC, Peng SY
International journal for parasitology 2022 Apr;52(5):275-284
International journal for parasitology 2022 Apr;52(5):275-284
Botox-A improve the thyroid-associated ophthalmopathy (TAO) orbital fibroblast activation through inhibiting the TGF-β/Smad signaling.
Qi X, Luo B, Deng M, Cao J, Hou S, Xie Z, Tong B, Xiong W
Experimental eye research 2022 Apr;217:108971
Experimental eye research 2022 Apr;217:108971
Pharmacological targeting macrophage phenotype via gut-kidney axis ameliorates renal fibrosis in mice.
Xie Y, Hu X, Li S, Qiu Y, Cao R, Xu C, Lu C, Wang Z, Yang J
Pharmacological research 2022 Apr;178:106161
Pharmacological research 2022 Apr;178:106161
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways.
Liu Z, Xu B, Ding Y, Ding X, Yang Z
Bioengineered 2022 Apr;13(4):9357-9368
Bioengineered 2022 Apr;13(4):9357-9368
HPV(+) HNSCC-derived exosomal miR-9-5p inhibits TGF-β signaling-mediated fibroblast phenotypic transformation through NOX4.
Wang B, Zhang S, Tong F, Wang Y, Wei L
Cancer science 2022 Apr;113(4):1475-1487
Cancer science 2022 Apr;113(4):1475-1487
Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice.
Song Z, Wang L, Cao Y, Liu Z, Zhang M, Zhang Z, Jiang S, Fan R, Hao T, Yang R, Wang B, Guan Z, Zhu L, Liu Z, Zhang S, Zhao L, Xu Z, Xu H, Dai G
International immunopharmacology 2022 Apr;105:108539
International immunopharmacology 2022 Apr;105:108539
Mechanosensitive Piezo1 channels mediate renal fibrosis.
Zhao X, Kong Y, Liang B, Xu J, Lin Y, Zhou N, Li J, Jiang B, Cheng J, Li C, Wang W
JCI insight 2022 Apr 8;7(7)
JCI insight 2022 Apr 8;7(7)
PEDF is an antifibrosis factor that inhibits the activation of fibroblasts in a bleomycin-induced pulmonary fibrosis rat model.
Qin X, Jia C, Liang J, Chen J, Liu X, Chao Z, Qin H, Yuan Y, Liu Z, Zhang Z, Dong H, Zhang H
Respiratory research 2022 Apr 22;23(1):100
Respiratory research 2022 Apr 22;23(1):100
TRPM2 Promotes Atherosclerotic Progression in a Mouse Model of Atherosclerosis.
Zhang Y, Ying F, Tian X, Lei Z, Li X, Lo CY, Li J, Jiang L, Yao X
Cells 2022 Apr 22;11(9)
Cells 2022 Apr 22;11(9)
MED12 Regulates Smooth Muscle Cell Functions and Participates in the Development of Aortic Dissection.
Zhou Y, Zha L, Wu J, Wang M, Zhou M, Wu G, Cheng X, Huang Z, Xie Q, Tu X
Genes 2022 Apr 14;13(4)
Genes 2022 Apr 14;13(4)
BRCC36 prevents vascular calcification in chronic kidney disease through the β-catenin signalling pathway.
Xie C, Chen C, Wu L, Xiong Y, Xing C, Mao H
Experimental cell research 2022 Apr 1;413(1):113051
Experimental cell research 2022 Apr 1;413(1):113051
Effect of Microgroove Structure in PDMS-Based Silicone Implants on Biocompatibility.
Chen Y, Zhou X, Huang S, Lan Y, Yan R, Shi X, Li X, Zhang Y, Lei Z, Fan D
Frontiers in bioengineering and biotechnology 2021;9:793778
Frontiers in bioengineering and biotechnology 2021;9:793778
Osteopontin N-Terminal Function in an Abdominal Aortic Aneurysm From Apolipoprotein E-Deficient Mice.
Liu H, Zhang Y, Song W, Sun Y, Jiang Y
Frontiers in cell and developmental biology 2021;9:681790
Frontiers in cell and developmental biology 2021;9:681790
Aberrantly Expressed Galectin-9 Is Involved in the Immunopathogenesis of Anti-MDA5-Positive Dermatomyositis-Associated Interstitial Lung Disease.
Liang L, Zhang YM, Shen YW, Song AP, Li WL, Ye LF, Lu X, Wang GC, Peng QL
Frontiers in cell and developmental biology 2021;9:628128
Frontiers in cell and developmental biology 2021;9:628128
JMJD1A/NR4A1 Signaling Regulates the Procession of Renal Tubular Epithelial Interstitial Fibrosis Induced by AGEs in HK-2.
Wang S, Zuo A, Jiang W, Xie J, Lin H, Sun W, Zhao M, Xia J, Shao J, Zhao X, Liang D, Yang A, Sun J, Wang M
Frontiers in medicine 2021;8:807694
Frontiers in medicine 2021;8:807694
STAT3 and IL-6 Contribute to Corticosteroid Resistance in an OVA and Ozone-induced Asthma Model with Neutrophil Infiltration.
Xue Y, Zhou Y, Bao W, Fu Q, Hao H, Han L, Zhang X, Tian X, Zhang M
Frontiers in molecular biosciences 2021;8:717962
Frontiers in molecular biosciences 2021;8:717962
Circulating Soluble Suppression of Tumorigenicity 2 Predicts Recurrence After Radiofrequency Ablation of Persistent Atrial Fibrillation.
Tan R, Yu H, Han X, Liu Y, Yang X, Xia YL, Yin X
Frontiers in cardiovascular medicine 2021;8:653312
Frontiers in cardiovascular medicine 2021;8:653312
Exosomes Containing LINC00636 Inhibit MAPK1 through the miR-450a-2-3p Overexpression in Human Pericardial Fluid and Improve Cardiac Fibrosis in Patients with Atrial Fibrillation.
Liu L, Luo F, Lei K
Mediators of inflammation 2021;2021:9960241
Mediators of inflammation 2021;2021:9960241
Nobiletin Attenuates Pathological Cardiac Remodeling after Myocardial Infarction via Activating PPARγ and PGC1α.
Zhou Y, Yin T, Shi M, Chen M, Wu X, Wang K, Cheang I, Li Y, Shang H, Zhang H, Li X
PPAR research 2021;2021:9947656
PPAR research 2021;2021:9947656
Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates.
Zhang M, Luo C, Lin D, Cui K, Chen Z, Liu J
Oxidative medicine and cellular longevity 2021;2021:8877540
Oxidative medicine and cellular longevity 2021;2021:8877540
Sodium Houttuyfonate Ameliorates β-amyloid(1-42)-Induced Memory Impairment and Neuroinflammation through Inhibiting the NLRP3/GSDMD Pathway in Alzheimer's Disease.
Zhao Y, Tian Y, Feng T
Mediators of inflammation 2021;2021:8817698
Mediators of inflammation 2021;2021:8817698
Network Pharmacology-Based Mechanistic Investigation of Jinshui Huanxian Formula Acting on Idiopathic Pulmonary Fibrosis.
Liu T, Xu P, Qi S, Ke S, Hu Q, Zhao P, Li J
Evidence-based complementary and alternative medicine : eCAM 2021;2021:8634705
Evidence-based complementary and alternative medicine : eCAM 2021;2021:8634705
PP2 Ameliorates Renal Fibrosis by Regulating the NF-κB/COX-2 and PPARγ/UCP2 Pathway in Diabetic Mice.
Wei J, Deng X, Li Y, Li R, Yang Z, Li X, Song S, Shi Y, Duan H, Wu H
Oxidative medicine and cellular longevity 2021;2021:7394344
Oxidative medicine and cellular longevity 2021;2021:7394344
Ginkgo Biloba Extract EGB761 Ameliorates the Extracellular Matrix Accumulation and Mesenchymal Transformation of Renal Tubules in Diabetic Kidney Disease by Inhibiting Endoplasmic Reticulum Stress.
Han J, Pang X, Shi X, Zhang Y, Peng Z, Xing Y
BioMed research international 2021;2021:6657206
BioMed research international 2021;2021:6657206
Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice.
Fang L, Wang W, Chen J, Zuo A, Gao H, Yan T, Wang P, Lu Y, Lv R, Xu F, Chen Y, Lyu L
Oxidative medicine and cellular longevity 2021;2021:3309944
Oxidative medicine and cellular longevity 2021;2021:3309944
Puerarin Alleviates UUO-Induced Inflammation and Fibrosis by Regulating the NF-κB P65/STAT3 and TGFβ1/Smads Signaling Pathways.
Wang J, Ge S, Wang Y, Liu Y, Qiu L, Li J, Huang X, Sun L
Drug design, development and therapy 2021;15:3697-3708
Drug design, development and therapy 2021;15:3697-3708
Wogonin Alleviates Kidney Tubular Epithelial Injury in Diabetic Nephropathy by Inhibiting PI3K/Akt/NF-κB Signaling Pathways.
Lei L, Zhao J, Liu XQ, Chen J, Qi XM, Xia LL, Wu YG
Drug design, development and therapy 2021;15:3131-3150
Drug design, development and therapy 2021;15:3131-3150
Fasudil Dichloroacetate Alleviates SU5416/Hypoxia-Induced Pulmonary Arterial Hypertension by Ameliorating Dysfunction of Pulmonary Arterial Smooth Muscle Cells.
Liu P, Huang W, Ding Y, Wu J, Liang Z, Huang Z, Xie W, Kong H
Drug design, development and therapy 2021;15:1653-1666
Drug design, development and therapy 2021;15:1653-1666
Overexpression of TC2N is associated with poor prognosis in gastric cancer.
Xu J, Ou X, Li J, Cai Q, Sun K, Ye J, Peng J
Journal of Cancer 2021;12(3):807-817
Journal of Cancer 2021;12(3):807-817
Tongluo Yishen Decoction Ameliorates Renal Fibrosis via Regulating Mitochondrial Dysfunction Induced by Oxidative Stress in Unilateral Ureteral Obstruction Rats.
Jia Q, Han L, Zhang X, Yang W, Gao Y, Shen Y, Li B, Wang S, Qin M, Lowe S, Qin J, Hao G
Frontiers in pharmacology 2021;12:762756
Frontiers in pharmacology 2021;12:762756
β2-Adrenergic Receptor Enhances the Alternatively Activated Macrophages and Promotes Biliary Injuries Caused by Helminth Infection.
Koda S, Zhang B, Zhou QY, Xu N, Li J, Liu JX, Liu M, Lv ZY, Wang JL, Shi Y, Gao S, Yu Q, Li XY, Xu YH, Chen JX, Tekengne BOT, Adzika GK, Tang RX, Sun H, Zheng KY, Yan C
Frontiers in immunology 2021;12:754208
Frontiers in immunology 2021;12:754208
Identification of a Novel Gene Correlated With Vascular Smooth Muscle Cells Proliferation and Migration in Chronic Thromboembolic Pulmonary Hypertension.
Wang F, Sun C, Lv X, Sun M, Si C, Zhen Y, Guo J, Sun W, Ye Z, Wen J, Liu P
Frontiers in physiology 2021;12:744219
Frontiers in physiology 2021;12:744219
Transcriptome-Based Network Analysis Reveals Hirudin Potentiates Anti-Renal Fibrosis Efficacy in UUO Rats.
Yu HX, Lin W, Yang K, Wei LJ, Chen JL, Liu XY, Zhong K, Chen X, Pei M, Yang HT
Frontiers in pharmacology 2021;12:741801
Frontiers in pharmacology 2021;12:741801
Icariin Ameliorates Diabetic Renal Tubulointerstitial Fibrosis by Restoring Autophagy via Regulation of the miR-192-5p/GLP-1R Pathway.
Jia Z, Wang K, Zhang Y, Duan Y, Xiao K, Liu S, Ding X
Frontiers in pharmacology 2021;12:720387
Frontiers in pharmacology 2021;12:720387
Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis Partly by Inhibiting the Expression of LOX and LOXL-2.
Tong X, Zhang S, Wang D, Zhang L, Huang J, Zhang T, Fan H
Frontiers in pharmacology 2021;12:709819
Frontiers in pharmacology 2021;12:709819
Comprehensive Bioinformatics Analysis Identifies POLR2I as a Key Gene in the Pathogenesis of Hypertensive Nephropathy.
You S, Xu J, Wu B, Wu S, Zhang Y, Sun Y, Zhang N
Frontiers in genetics 2021;12:698570
Frontiers in genetics 2021;12:698570
Exploration of the Modulatory Property Mechanism of ELeng Capsule in the Treatment of Endometriosis Using Transcriptomics Combined With Systems Network Pharmacology.
Zheng W, Wang J, Wu J, Wang T, Huang Y, Liang X, Cao L
Frontiers in pharmacology 2021;12:674874
Frontiers in pharmacology 2021;12:674874
ShenLian Extract Enhances TGF-β Functions in the Macrophage-SMC Unit and Stabilizes Atherosclerotic Plaques.
Liu L, Li Q, Yin J, Zhao Z, Sun L, Ran Q, Du X, Wang Y, Li Y, Yang Q, Chen Y, Weng X, Cai W, Zhu X
Frontiers in pharmacology 2021;12:669730
Frontiers in pharmacology 2021;12:669730
Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.
Zhou F, Zhang X, Jiang L, Li S, Chen Y, Wu J
Frontiers in pharmacology 2021;12:667524
Frontiers in pharmacology 2021;12:667524
iTRAQ-Based Proteomics Reveals Gu-Ben-Fang-Xiao Decoction Alleviates Airway Remodeling via Reducing Extracellular Matrix Deposition in a Murine Model of Chronic Remission Asthma.
Xing Q, You Y, Zhao X, Ji J, Yan H, Dong Y, Ren L, Ding Y, Hou S
Frontiers in pharmacology 2021;12:588588
Frontiers in pharmacology 2021;12:588588
Exogenous H(2) S prevents the nuclear translocation of PDC-E1 and inhibits vascular smooth muscle cell proliferation in the diabetic state.
Zhang L, Jiang X, Liu N, Li M, Kang J, Chen L, Tang J, Dong S, Lu F, Zhang W
Journal of cellular and molecular medicine 2021 Sep;25(17):8201-8214
Journal of cellular and molecular medicine 2021 Sep;25(17):8201-8214
Interferon-induced protein 16 expression in colorectal cancer and its correlation with proliferation and immune signature markers.
Zou Y, Zhang J, Zhang L, Yan X
Oncology letters 2021 Sep;22(3):687
Oncology letters 2021 Sep;22(3):687
Presegetane diterpenoids from Euphorbia sieboldiana as a new type of anti-liver fibrosis agents that inhibit TGF-β/Smad signaling pathway.
Li S, Gan L, Tian YJ, Tian Y, Fan RZ, Huang D, Yuan FY, Zhang X, Lin Y, Zhu QF, Tang GH, Yan XL, Yin S
Bioorganic chemistry 2021 Sep;114:105222
Bioorganic chemistry 2021 Sep;114:105222
Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus.
Inoue Y, Masuda T, Misumi Y, Ando Y, Ueda M
Neuroscience letters 2021 Sep 25;762:136136
Neuroscience letters 2021 Sep 25;762:136136
MiR-200c-3p promotes ox-LDL-induced endothelial to mesenchymal transition in human umbilical vein endothelial cells through SMAD7/YAP pathway.
Mao Y, Jiang L
The journal of physiological sciences : JPS 2021 Sep 15;71(1):30
The journal of physiological sciences : JPS 2021 Sep 15;71(1):30
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Pei Z, Yang C, Guo Y, Dong M, Wang F
Aging 2021 Sep 14;13(17):21700-21711
Aging 2021 Sep 14;13(17):21700-21711
The promoting role of Cx43 on the proliferation and migration of arterial smooth muscle cells for angiotensin II-dependent hypertension.
Gao RJ, Zhang AM, Jia QH, Dang ZT, Tian T, Zhang JR, Cao N, Tang XC, Ma KT, Li L, Si JQ
Pulmonary pharmacology & therapeutics 2021 Oct;70:102072
Pulmonary pharmacology & therapeutics 2021 Oct;70:102072
Heat-killed Propionibacterium acnes augment the protective effect of 28-kDa glutathione S-transferases antigen against Schistosoma mansoni infection.
Lam HYP, Yang TH, Liang TR, Cheng PC, Chang KC, Peng SY
Acta tropica 2021 Oct;222:106033
Acta tropica 2021 Oct;222:106033
Potential Vasculoprotective Effects of Blackcurrant (Ribes nigrum) Extract in Diabetic KK-A(y) Mice.
Horie K, Maeda H, Nanashima N, Oey I
Molecules (Basel, Switzerland) 2021 Oct 26;26(21)
Molecules (Basel, Switzerland) 2021 Oct 26;26(21)
Structure-Guided Design of a Small-Molecule Activator of Sirtuin-3 that Modulates Autophagy in Triple Negative Breast Cancer.
Zhang J, Zou L, Shi D, Liu J, Zhang J, Zhao R, Wang G, Zhang L, Ouyang L, Liu B
Journal of medicinal chemistry 2021 Oct 14;64(19):14192-14216
Journal of medicinal chemistry 2021 Oct 14;64(19):14192-14216
METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner.
Zhao K, Yang C, Zhang J, Sun W, Zhou B, Kong X, Shi J
Cell death discovery 2021 Oct 13;7(1):291
Cell death discovery 2021 Oct 13;7(1):291
Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway.
Tan X, Cai D, Chen N, Du S, Qiao D, Yue X, Wang T, Li J, Xie W, Wang H
Toxicology letters 2021 Oct 10;350:98-110
Toxicology letters 2021 Oct 10;350:98-110
Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling.
Zou Y, Chen Z, Sun C, Yang D, Zhou Z, Peng X, Zheng L, Tang C
International journal of molecular sciences 2021 Oct 10;22(20)
International journal of molecular sciences 2021 Oct 10;22(20)
Low-intensity pulsed ultrasound prevents prolonged hypoxia-induced cardiac fibrosis through HIF-1α/DNMT3a pathway via a TRAAK-dependent manner.
Zhao K, Weng L, Xu T, Yang C, Zhang J, Ni G, Guo X, Tu J, Zhang D, Sun W, Kong X
Clinical and experimental pharmacology & physiology 2021 Nov;48(11):1500-1514
Clinical and experimental pharmacology & physiology 2021 Nov;48(11):1500-1514
Inhibition of MAD2B alleviates venous neointimal formation by suppressing VSMCs proliferation and migration.
Song AN, Yin XJ, Gao P, Tang H, Meng XF, Zhang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Nov;35(11):e21959
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Nov;35(11):e21959
Dysregulations of miR-503-5p and Wnt/β-catenin pathway coordinate in mediating cadmium-induced kidney fibrosis.
Liang L, Huang K, Yuan W, Liu L, Zou F, Wang G
Ecotoxicology and environmental safety 2021 Nov;224:112667
Ecotoxicology and environmental safety 2021 Nov;224:112667
Blood glucose control contributes to protein stability of Ski-related novel protein N in a rat model of diabetes.
Liang L, Li S, Liu H, Mao Y, Liu L, Zhang X, Peng W, Xiao Y, Zhang F, Shi M, Wang Y, Guo B
Experimental and therapeutic medicine 2021 Nov;22(5):1341
Experimental and therapeutic medicine 2021 Nov;22(5):1341
Maiwei Yangfei decoction prevents bleomycin-induced pulmonary fibrosis in mice.
Xu Y, Peng W, Han D, Feng F, Wang Z, Gu C, Zhou X, Wu Q
Experimental and therapeutic medicine 2021 Nov;22(5):1306
Experimental and therapeutic medicine 2021 Nov;22(5):1306
Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension.
Lv Y, Ma P, Wang J, Xu Q, Fan J, Yan L, Ma P, Zhou R
European journal of pharmacology 2021 Nov 5;910:174311
European journal of pharmacology 2021 Nov 5;910:174311
MyD88 in Macrophages Enhances Liver Fibrosis by Activation of NLRP3 Inflammasome in HSCs.
Ge S, Yang W, Chen H, Yuan Q, Liu S, Zhao Y, Zhang J
International journal of molecular sciences 2021 Nov 17;22(22)
International journal of molecular sciences 2021 Nov 17;22(22)
SAA1 is transcriptionally activated by STAT3 and accelerates renal interstitial fibrosis by inducing endoplasmic reticulum stress.
Zhang F, Zhou X, Zou H, Liu L, Li X, Ruan Y, Xie Y, Shi M, Xiao Y, Wang Y, Zhou Y, Wu Y, Guo B
Experimental cell research 2021 Nov 1;408(1):112856
Experimental cell research 2021 Nov 1;408(1):112856
ZC3H4 mediates silica-induced EndoMT via ER stress and autophagy.
Jiang R, Han L, Gao Q, Chao J
Environmental toxicology and pharmacology 2021 May;84:103605
Environmental toxicology and pharmacology 2021 May;84:103605
Establishment of an iPSC line (CSUXHi004-A) from a patient with Waardenburg syndrome type I caused by a PAX3 splice mutation.
Wen J, He C, Feng Y, Song J, Liu J, Liu X, Mei L, Ling J, Chen H, Liu Y
Stem cell research 2021 May;53:102300
Stem cell research 2021 May;53:102300
Macrophage-derived exosomes mediate silica-induced pulmonary fibrosis by activating fibroblast in an endoplasmic reticulum stress-dependent manner.
Qin X, Lin X, Liu L, Li Y, Li X, Deng Z, Chen H, Chen H, Niu Z, Li Z, Hu Y
Journal of cellular and molecular medicine 2021 May;25(9):4466-4477
Journal of cellular and molecular medicine 2021 May;25(9):4466-4477
MiR-155 promotes colitis-associated intestinal fibrosis by targeting HBP1/Wnt/β-catenin signalling pathway.
Li N, Ouyang Y, Xu X, Yuan Z, Liu C, Zhu Z
Journal of cellular and molecular medicine 2021 May;25(10):4765-4775
Journal of cellular and molecular medicine 2021 May;25(10):4765-4775
Splicing factor SRSF6 mediates pleural fibrosis.
Liang LM, Xiong L, Cheng PP, Chen SJ, Feng X, Zhou YY, Niu Q, Wang M, Chen Q, Song LJ, Yu F, He XL, Xiang F, Wang X, Ye H, Ma WL
JCI insight 2021 May 24;6(10)
JCI insight 2021 May 24;6(10)
Controlled release of KGF-2 for regulation of wound healing by KGF-2 complexed with "lotus seedpod surface-like" porous microspheres.
Pan H, Shi C, Yang R, Xi G, Lu C, Yang X, Chen J, Wang X, Chen L, Pan J
Journal of materials chemistry. B 2021 May 19;9(19):4039-4049
Journal of materials chemistry. B 2021 May 19;9(19):4039-4049
Glucagon-like peptide-1 (GLP-1) improved diabetic lung fibrosis via AMPK and microRNA-27a (miR-27a).
Liu J, Li X, Lu S, Zheng X, Zhang X, Zhao W
Annals of translational medicine 2021 Mar;9(6):492
Annals of translational medicine 2021 Mar;9(6):492
KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury.
Xu D, Chen PP, Zheng PQ, Yin F, Cheng Q, Zhou ZL, Xie HY, Li JY, Ni JY, Wang YZ, Chen SJ, Zhou L, Wang XX, Liu J, Zhang W, Lu LM
Acta pharmacologica Sinica 2021 Mar;42(3):436-450
Acta pharmacologica Sinica 2021 Mar;42(3):436-450
Scoparone alleviates Ang II-induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress.
Lyu L, Chen J, Wang W, Yan T, Lin J, Gao H, Li H, Lv R, Xu F, Fang L, Chen Y
Journal of cellular and molecular medicine 2021 Mar;25(6):3136-3148
Journal of cellular and molecular medicine 2021 Mar;25(6):3136-3148
A selective small-molecule inhibitor of c-Met suppresses keloid fibroblast growth in vitro and in a mouse model.
Choi MH, Kim J, Ha JH, Park JU
Scientific reports 2021 Mar 9;11(1):5468
Scientific reports 2021 Mar 9;11(1):5468
Amyloid pathology arrangements in Alzheimer's disease brains modulate in vivo seeding capability.
Duran-Aniotz C, Moreno-Gonzalez I, Gamez N, Perez-Urrutia N, Vegas-Gomez L, Soto C, Morales R
Acta neuropathologica communications 2021 Mar 30;9(1):56
Acta neuropathologica communications 2021 Mar 30;9(1):56
Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway.
Chen Y, Xu T, Li M, Li C, Ma Y, Chen G, Sun Y, Zheng H, Wu G, Liao W, Liao Y, Chen Y, Bin J
Clinical science (London, England : 1979) 2021 Mar 26;135(6):811-828
Clinical science (London, England : 1979) 2021 Mar 26;135(6):811-828
Study on the effect of Mongolian medicine Qiwei Qinggan Powder on hepatic fibrosis through JAK2/STAT3 pathway.
Liang J, Yuan H, Xu L, Wang F, Bao X, Yan Y, Wang H, Zhang C, Jin R, Ma L, Zhang J, Huri L, Su X, Xiao R, Ma Y
Bioscience, biotechnology, and biochemistry 2021 Mar 24;85(4):775-785
Bioscience, biotechnology, and biochemistry 2021 Mar 24;85(4):775-785
Anti-Fibrosis Effects of Magnesium Lithospermate B in Experimental Pulmonary Fibrosis: By Inhibiting TGF-βRI/Smad Signaling.
Luo X, Deng Q, Xue Y, Zhang T, Wu Z, Peng H, Xuan L, Pan G
Molecules (Basel, Switzerland) 2021 Mar 19;26(6)
Molecules (Basel, Switzerland) 2021 Mar 19;26(6)
The MIR155 host gene/microRNA-627/HMGB1/NF-κB loop modulates fibroblast proliferation and extracellular matrix deposition.
Li J, Zhang X, Wang T, Li J, Su Q, Zhong C, Chen Z, Liang Y
Life sciences 2021 Mar 15;269:119085
Life sciences 2021 Mar 15;269:119085
Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis.
Zheng S, Cao P, Yin Z, Wang X, Chen Y, Yu M, Xu B, Liao C, Duan Y, Zhang S, Han J, Yang X
Food & function 2021 Mar 15;12(5):2323-2334
Food & function 2021 Mar 15;12(5):2323-2334
Circular RNA UVRAG Mediated by Alternative Splicing Factor NOVA1 Regulates Adhesion and Migration of Vascular Smooth Muscle Cells.
Liu Z, Lou Y, Cui JC, Chen Y, Liu JT, Yuan Y, Han Y, Huo YL, Qi YX, Jiang ZL, Yao QP
Genes 2021 Mar 14;12(3)
Genes 2021 Mar 14;12(3)
Photobiomodulation therapy promotes the ATP-binding cassette transporter A1-dependent cholesterol efflux in macrophage to ameliorate atherosclerosis.
Yin Q, Chang H, Shen Q, Xing D
Journal of cellular and molecular medicine 2021 Jun;25(11):5238-5249
Journal of cellular and molecular medicine 2021 Jun;25(11):5238-5249
Fructose-1,6-bisphosphatase aggravates oxidative stress-induced apoptosis in asthma by suppressing the Nrf2 pathway.
Hu J, Wang J, Li C, Shang Y
Journal of cellular and molecular medicine 2021 Jun;25(11):5001-5014
Journal of cellular and molecular medicine 2021 Jun;25(11):5001-5014
Ameliorative effects of Schisandrin B on Schistosoma mansoni-induced hepatic fibrosis in vivo.
Lam HYP, Liang TR, Peng SY
PLoS neglected tropical diseases 2021 Jun;15(6):e0009554
PLoS neglected tropical diseases 2021 Jun;15(6):e0009554
Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice.
Wang D, Yin Z, Ma L, Han L, Chen Y, Pan W, Gong K, Gao Y, Yang X, Chen Y, Han J, Duan Y
Food & function 2021 Jun 7;12(11):4842-4854
Food & function 2021 Jun 7;12(11):4842-4854
Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway.
Liang Y, Chen G, Zhang F, Yang X, Chen Y, Duan Y, Yu M, Zhang S, Han J
Antioxidants (Basel, Switzerland) 2021 Jun 5;10(6)
Antioxidants (Basel, Switzerland) 2021 Jun 5;10(6)
Interleukin-6 participates in human pancreatic stellate cell activation and collagen I production via TGF-β1/Smad pathway.
Zheng M, Li H, Sun L, Brigstock DR, Gao R
Cytokine 2021 Jul;143:155536
Cytokine 2021 Jul;143:155536
C188-9 reduces TGF-β1-induced fibroblast activation and alleviates ISO-induced cardiac fibrosis in mice.
Liu J, Jin Y, Wang B, Zhang J, Zuo S
FEBS open bio 2021 Jul;11(7):2033-2040
FEBS open bio 2021 Jul;11(7):2033-2040
ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy.
Lu L, Zhong Z, Gu J, Nan K, Zhu M, Miao C
Molecular medicine (Cambridge, Mass.) 2021 Jul 8;27(1):74
Molecular medicine (Cambridge, Mass.) 2021 Jul 8;27(1):74
Dopamine D1 receptor alleviates doxorubicin-induced cardiac injury by inhibiting NLRP3 inflammasome.
Liu J, Jin Y, Wang B, Wang Y, Zuo S, Zhang J
Biochemical and biophysical research communications 2021 Jul 5;561:7-13
Biochemical and biophysical research communications 2021 Jul 5;561:7-13
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability.
Wu M, Chen W, Miao M, Jin Q, Zhang S, Bai M, Fan J, Zhang Y, Zhang A, Jia Z, Huang S
Clinical science (London, England : 1979) 2021 Jul 30;135(14):1707-1726
Clinical science (London, England : 1979) 2021 Jul 30;135(14):1707-1726
Mesenchymal stem cells ameliorate renal fibrosis by galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat.
Tang H, Zhang P, Zeng L, Zhao Y, Xie L, Chen B
Stem cell research & therapy 2021 Jul 16;12(1):409
Stem cell research & therapy 2021 Jul 16;12(1):409
Type 2 Alveolar Epithelial Cells Differentiated from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Mouse Pulmonary Fibrosis Through β-Catenin-Regulated Cell Apoptosis.
Liu J, Peng D, You J, Zhou O, Qiu H, Hao C, Chen H, Fu Z, Zou L
Stem cells and development 2021 Jul 1;30(13):660-670
Stem cells and development 2021 Jul 1;30(13):660-670
Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression.
Chen C, Gu J, Wang J, Wu Y, Yang A, Chen T, Zhou T, Liu Z
International immunopharmacology 2021 Jan;90:107206
International immunopharmacology 2021 Jan;90:107206
Amygdalin inhibits TGFβ1-induced activation of hepatic stellate cells (HSCs) in vitro and CCl(4)-induced hepatic fibrosis in rats in vivo.
Wang R, Zhang D, Tang D, Sun K, Peng J, Zhu W, Yin S, Wu Y
International immunopharmacology 2021 Jan;90:107151
International immunopharmacology 2021 Jan;90:107151
Effect of human umbilical cord-derived mesenchymal stem cells on murine model of bronchiolitis obliterans like injury.
Lin J, Deng H, Zhang Y, Zou L, Fu Z, Dai J
Pediatric pulmonology 2021 Jan;56(1):129-137
Pediatric pulmonology 2021 Jan;56(1):129-137
Tormentic acid inhibits hepatic stellate cells activation via blocking PI3K/Akt/mTOR and NF-κB signalling pathways.
Lin X, Li Y, Zhang X, Wei Y, Wen S, Lu Z, Huang Q, Wei J
Cell biochemistry and function 2021 Jan;39(1):77-87
Cell biochemistry and function 2021 Jan;39(1):77-87
Selective eradication of pluripotent stem cells by inhibiting DHODH activity.
Kondo T
Stem cells (Dayton, Ohio) 2021 Jan;39(1):33-42
Stem cells (Dayton, Ohio) 2021 Jan;39(1):33-42
Endogenous hydrogen sulfide improves vascular remodeling through PPARδ/SOCS3 signaling.
Tian D, Teng X, Jin S, Chen Y, Xue H, Xiao L, Wu Y
Journal of advanced research 2021 Jan;27:115-125
Journal of advanced research 2021 Jan;27:115-125
Comparative cytotoxicity studies of halophenolic disinfection byproducts using human extended pluripotent stem cells.
Liu Y, Zhu D, Zhao Z, Zhou Q, Pan Y, Shi W, Qiu J, Yang Y
Chemosphere 2021 Jan;263:127899
Chemosphere 2021 Jan;263:127899
Hypoxia-induced FOXO4/LDHA axis modulates gastric cancer cell glycolysis and progression.
Wang XH, Jiang ZH, Yang HM, Zhang Y, Xu LH
Clinical and translational medicine 2021 Jan;11(1):e279
Clinical and translational medicine 2021 Jan;11(1):e279
Indoleamine 2,3-dioxygenase 1 limits hepatic inflammatory cells recruitment and promotes bile duct ligation-induced liver fibrosis.
Mo C, Xie S, Liu B, Zhong W, Zeng T, Huang S, Lai Y, Deng G, Zhou C, Yan W, Chen Y, Huang S, Gao L, Lv Z
Cell death & disease 2021 Jan 7;12(1):16
Cell death & disease 2021 Jan 7;12(1):16
Identification of key pathways and hub genes in the myogenic differentiation of pluripotent stem cell: a bioinformatics and experimental study.
Fei W, Liu M, Zhang Y, Cao S, Wang X, Xie B, Wang J
Journal of orthopaedic surgery and research 2021 Jan 4;16(1):4
Journal of orthopaedic surgery and research 2021 Jan 4;16(1):4
MiR-30c-5p regulates adventitial progenitor cells differentiation to vascular smooth muscle cells through targeting OPG.
Zhang Q, Chen T, Zhang Y, Lyu L, Zhang B, Huang C, Zhou X, Wu Y, Li Z
Stem cell research & therapy 2021 Jan 19;12(1):67
Stem cell research & therapy 2021 Jan 19;12(1):67
The zonula occludens protein family regulates the hepatic barrier system in the murine liver.
Itoh M, Terada M, Sugimoto H
Biochimica et biophysica acta. Molecular basis of disease 2021 Jan 1;1867(1):165994
Biochimica et biophysica acta. Molecular basis of disease 2021 Jan 1;1867(1):165994
Up-regulation of FUT8 inhibits TGF-β1-induced activation of hepatic stellate cells during liver fibrogenesis.
Kuang M, Wu H, Hu L, Guo X, He D, Liu B, Chen M, Gu J, Gu J, Zeng X, Ruan Y
Glycoconjugate journal 2021 Feb;38(1):77-87
Glycoconjugate journal 2021 Feb;38(1):77-87
FoxM1 promotes Wnt/β-catenin pathway activation and renal fibrosis via transcriptionally regulating multi-Wnts expressions.
Xie H, Miao N, Xu D, Zhou Z, Ni J, Yin F, Wang Y, Cheng Q, Chen P, Li J, Zheng P, Zhou L, Liu J, Zhang W, Wang X, Lu L
Journal of cellular and molecular medicine 2021 Feb;25(4):1958-1971
Journal of cellular and molecular medicine 2021 Feb;25(4):1958-1971
Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress.
Wu L, Wang Q, Guo F, Ma X, Wang J, Zhao Y, Yan Y, Qin G
Journal of cellular physiology 2021 Feb;236(2):1454-1468
Journal of cellular physiology 2021 Feb;236(2):1454-1468
Keratin 1 attenuates hypoxic pulmonary artery hypertension by suppressing pulmonary artery media smooth muscle expansion.
Zhang L, Zeng XX, Li YM, Chen SK, Tang LY, Wang N, Yang X, Lin MJ
Acta physiologica (Oxford, England) 2021 Feb;231(2):e13558
Acta physiologica (Oxford, England) 2021 Feb;231(2):e13558
BML-111, the lipoxin A4 agonist, modulates VEGF or CoCl2-induced migration, angiogenesis and permeability in tumor-derived endothelial cells.
Lin L, Wang Q, Xu F, Luo X, Xu J, Yan L, Li Q, Hao H
Immunology letters 2021 Feb;230:27-35
Immunology letters 2021 Feb;230:27-35
Fe(3)O(4) magnetic nanoparticles ameliorate albumin-induced tubulointerstitial fibrosis by autophagy related to Rab7.
Liu L, Xu Q, Zhang L, Sun H, Ding F, Li Y, Chen P
Colloids and surfaces. B, Biointerfaces 2021 Feb;198:111470
Colloids and surfaces. B, Biointerfaces 2021 Feb;198:111470
Osteogenic differentiation and calcification of human aortic smooth muscle cells is induced by the RCN2/STAT3/miR-155-5p feedback loop.
Zhao J, Liu Z, Chang Z
Vascular pharmacology 2021 Feb;136:106821
Vascular pharmacology 2021 Feb;136:106821
Preparation of a recombinant collagen-peptide (RHC)-conjugated chitosan thermosensitive hydrogel for wound healing.
Deng A, Yang Y, Du S, Yang X, Pang S, Wang X, Yang S
Materials science & engineering. C, Materials for biological applications 2021 Feb;119:111555
Materials science & engineering. C, Materials for biological applications 2021 Feb;119:111555
Ursodesoxycholic acid alleviates liver fibrosis via proregeneration by activation of the ID1-WNT2/HGF signaling pathway.
Dong X, Luo Y, Lu S, Ma H, Zhang W, Zhu Y, Sun G, Sun X
Clinical and translational medicine 2021 Feb;11(2):e296
Clinical and translational medicine 2021 Feb;11(2):e296
miR-184 targets TP63 to block idiopathic pulmonary fibrosis by inhibiting proliferation and epithelial-mesenchymal transition of airway epithelial cells.
Li J, Pan C, Tang C, Tan W, Zhang W, Guan J
Laboratory investigation; a journal of technical methods and pathology 2021 Feb;101(2):142-154
Laboratory investigation; a journal of technical methods and pathology 2021 Feb;101(2):142-154
Blackcurrant (Ribes nigrum L.) Extract Exerts Potential Vasculoprotective Effects in Ovariectomized Rats, Including Prevention of Elastin Degradation and Pathological Vascular Remodeling.
Horie K, Nanashima N, Maeda H, Tomisawa T, Oey I
Nutrients 2021 Feb 8;13(2)
Nutrients 2021 Feb 8;13(2)
Homocysteine promotes cardiac fibrosis by regulating the Akt/FoxO3 pathway.
Shi Y, Zhao L, Zhang Y, Qin Q, Cong H, Guo Z
Annals of translational medicine 2021 Dec;9(23):1732
Annals of translational medicine 2021 Dec;9(23):1732
NAMPT-mediated NAD(+) biosynthesis suppresses activation of hepatic stellate cells and protects against CCl(4)-induced liver fibrosis in mice.
Xu L, Yang C, Ma J, Zhang X, Wang Q, Xiong X
Human & experimental toxicology 2021 Dec;40(12_suppl):S666-S675
Human & experimental toxicology 2021 Dec;40(12_suppl):S666-S675
Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial-mesenchymal plasticity of human peritoneal mesothelial cells.
Gao L, Nie X, Gou R, Hu Y, Dong H, Li X, Lin B
Journal of cellular and molecular medicine 2021 Dec;25(23):10916-10929
Journal of cellular and molecular medicine 2021 Dec;25(23):10916-10929
Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.
Zhao X, Wang J, Tang L, Li P, Ru J, Bai Y
Bioengineered 2021 Dec;12(1):589-600
Bioengineered 2021 Dec;12(1):589-600
Vasoactive intestinal peptide attenuates bleomycin-induced murine pulmonary fibrosis by inhibiting epithelial-mesenchymal transition: Restoring autophagy in alveolar epithelial cells.
Duan JX, Guan XX, Yang HH, Mei WX, Chen P, Tao JH, Li Q, Zhou Y
International immunopharmacology 2021 Dec;101(Pt B):108211
International immunopharmacology 2021 Dec;101(Pt B):108211
MicroRNA-210-5p alleviates cardiac fibrosis via targeting transforming growth factor-beta type I receptor in rats on high sodium chloride (NaCl)-based diet.
Zhao K, Mao Y, Ye X, Ma J, Sun L, Li P, Li Y
European journal of pharmacology 2021 Dec 5;912:174587
European journal of pharmacology 2021 Dec 5;912:174587
Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis.
Yi J, Wu S, Tan S, Qin Y, Wang X, Jiang J, Liu H, Wu B
Cell death discovery 2021 Dec 4;7(1):374
Cell death discovery 2021 Dec 4;7(1):374
Inhibition of microRNA-30a alleviates vascular remodeling in pulmonary arterial hypertension.
Ma W, Qiu Z, Bai Z, Dai Y, Li C, Chen X, Song X, Shi D, Zhou Y, Pan Y, Liao Y, Liao M, Zhou Z
Molecular therapy. Nucleic acids 2021 Dec 3;26:678-693
Molecular therapy. Nucleic acids 2021 Dec 3;26:678-693
Pterostilbene Ameliorates Renal Damage in Diabetic Rats by Suppressing Hyperglycemia with Inhibition of Inflammatory and Fibrotic Responses.
Ding RR, Huang GY, Zhang YJ, Sun HL, Liu YM, Xu Z, Li WJ, Li X
Biomedical and environmental sciences : BES 2021 Dec 20;34(12):1015-1019
Biomedical and environmental sciences : BES 2021 Dec 20;34(12):1015-1019
Effects of L-leucine on the properties of spray-dried swellable microparticles with wrinkled surfaces for inhalation therapy of pulmonary fibrosis.
Wang X, Wan W, Lu J, Quan G, Pan X, Liu P
International journal of pharmaceutics 2021 Dec 15;610:121223
International journal of pharmaceutics 2021 Dec 15;610:121223
A suitable silicosis mouse model was constructed by repeated inhalation of silica dust via nose.
Li B, Mu M, Sun Q, Cao H, Liu Q, Liu J, Zhang J, Xu K, Hu D, Tao X, Wang J
Toxicology letters 2021 Dec 15;353:1-12
Toxicology letters 2021 Dec 15;353:1-12
Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation.
Gong X, Tian M, Cao N, Yang P, Xu Z, Zheng S, Liao Q, Chen C, Zeng C, Jose PA, Wang DZ, Jian Z, Xiao Y, Jiang DS, Wei X, Zhang B, Wang Y, Chen K, Wu G, Zeng C
The Journal of clinical investigation 2021 Dec 15;131(24)
The Journal of clinical investigation 2021 Dec 15;131(24)
RNO3 QTL regulates vascular structure and arterial stiffness in the spontaneously hypertensive rat.
Morgan EE, Morran MP, Horen NG, Weaver DA, Nestor-Kalinoski AL
Physiological genomics 2021 Dec 1;53(12):534-545
Physiological genomics 2021 Dec 1;53(12):534-545
Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization.
Wang Y, Lyu Y, Tu K, Xu Q, Yang Y, Salman S, Le N, Lu H, Chen C, Zhu Y, Wang R, Liu Q, Semenza GL
Science advances 2021 Aug;7(35)
Science advances 2021 Aug;7(35)
BGP-15 Inhibits Hyperglycemia-Aggravated VSMC Calcification Induced by High Phosphate.
Nagy A, Pethő D, Gesztelyi R, Juhász B, Balla G, Szilvássy Z, Balla J, Gáll T
International journal of molecular sciences 2021 Aug 26;22(17)
International journal of molecular sciences 2021 Aug 26;22(17)
PDGF-BB/SA/Dex injectable hydrogels accelerate BMSC-mediated functional full thickness skin wound repair by promoting angiogenesis.
Zhang Z, Li Z, Wang Y, Wang Q, Yao M, Zhao L, Shi J, Guan F, Ma S
Journal of materials chemistry. B 2021 Aug 21;9(31):6176-6189
Journal of materials chemistry. B 2021 Aug 21;9(31):6176-6189
Generation of an EFNB2-2A-mCherry reporter human embryonic stem cell line using CRISPR/Cas9-mediated site-specific homologous recombination.
Huang Y, Wu H, Han X, Wu J, Yu M, Zhao ZA, Shen Z, Hu S, Lei W
Stem cell research 2021 Apr;52:102241
Stem cell research 2021 Apr;52:102241
mRNA Transcriptome Analysis of Bone in a Mouse Model of Implant-Associated Staphylococcus aureus Osteomyelitis.
Lin Y, Su J, Wang Y, Xu D, Zhang X, Yu B
Infection and immunity 2021 Apr 16;89(5)
Infection and immunity 2021 Apr 16;89(5)
Inhibiting SLC26A4 reverses cardiac hypertrophy in H9C2 cells and in rats.
Tang L, Yu X, Zheng Y, Zhou N
PeerJ 2020;8:e8253
PeerJ 2020;8:e8253
The Effect of Resveratrol and Quercetin on Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem Cell.
Hoca M, Becer E, Kabadayı H, Yücecan S, Vatansever HS
Nutrition and cancer 2020;72(7):1231-1242
Nutrition and cancer 2020;72(7):1231-1242
Glutamate-Cysteine Ligase Catalytic Subunit Attenuated Hepatitis C Virus-Related Liver Fibrosis and Suppressed Endoplasmic Reticulum Stress.
Fu N, Li D, Li W, Zhao W, Zhang S, Liu L, Zhao S, Du J, Kong L, Wang R, Zhang Y, Nan Y
Frontiers in molecular biosciences 2020;7:199
Frontiers in molecular biosciences 2020;7:199
Sodium Tanshinone IIA Sulfonate Attenuates Erectile Dysfunction in Rats with Hyperlipidemia.
Zhong L, Ding W, Zeng Q, He B, Zhang H, Wang L, Fan J, He S, Zhang Y, Wei A
Oxidative medicine and cellular longevity 2020;2020:7286958
Oxidative medicine and cellular longevity 2020;2020:7286958
Bergenin Attenuates Hepatic Fibrosis by Regulating Autophagy Mediated by the PPAR-γ/TGF-β Pathway.
Xia Y, Li J, Chen K, Feng J, Guo C
PPAR research 2020;2020:6694214
PPAR research 2020;2020:6694214
Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner.
Gu J, Chen C, Wang J, Chen T, Yao W, Yan T, Liu Z
Oxidative medicine and cellular longevity 2020;2020:2452848
Oxidative medicine and cellular longevity 2020;2020:2452848
Biological and Proteomic Characteristics of an Immortalized Human Pancreatic Stellate Cell Line.
Sun L, Qu L, Brigstock DR, Li H, Li Y, Gao R
International journal of medical sciences 2020;17(1):137-144
International journal of medical sciences 2020;17(1):137-144
Septin4 Prevents PDGF-BB-induced HAVSMC Phenotypic Transformation, Proliferation and Migration by Promoting SIRT1-STAT3 Deacetylation and Dephosphorylation.
Zhang N, Zhang Y, You S, Tian Y, Lu S, Cao L, Sun Y
International journal of biological sciences 2020;16(4):708-718
International journal of biological sciences 2020;16(4):708-718
The role of Stim1 in the progression of lupus nephritis in mice.
Zhang F, Zhou X, Cui D, Zhang W, Lai J, Li X, Ruan Y, Xie Y, Shi M, Xiao Y, Wang Y, Zhou Y, Guo B
International journal of clinical and experimental pathology 2020;13(12):3021-3032
International journal of clinical and experimental pathology 2020;13(12):3021-3032
Inactivation of Pancreatic Stellate Cells by Exendin-4 Inhibits the Migration and Invasion of Pancreatic Cancer Cells.
Yan M, Shen M, Xu L, Huang J, He G, An M, Li X, Gao Z, Meng X
OncoTargets and therapy 2020;13:9455-9463
OncoTargets and therapy 2020;13:9455-9463
High-Intensity Interval Training Attenuates Ketogenic Diet-Induced Liver Fibrosis in Type 2 Diabetic Mice by Ameliorating TGF-β1/Smad Signaling.
Zhang Q, Shen F, Shen W, Xia J, Wang J, Zhao Y, Zhang Z, Sun Y, Qian M, Ding S
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:4209-4219
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:4209-4219
Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha.
Ndibalema AR, Kabuye D, Wen S, Li L, Li X, Fan Q
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:1953-1967
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:1953-1967
Notch3 Modulates Cardiac Fibroblast Proliferation, Apoptosis, and Fibroblast to Myofibroblast Transition via Negative Regulation of the RhoA/ROCK/Hif1α Axis.
Shi J, Xiao P, Liu X, Chen Y, Xu Y, Fan J, Yin Y
Frontiers in physiology 2020;11:669
Frontiers in physiology 2020;11:669
Integrating Network Pharmacology and Experimental Validation to Investigate the Effects and Mechanism of Astragalus Flavonoids Against Hepatic Fibrosis.
An L, Lin Y, Li L, Kong M, Lou Y, Wu J, Liu Z
Frontiers in pharmacology 2020;11:618262
Frontiers in pharmacology 2020;11:618262
Fisetin Alleviated Bleomycin-Induced Pulmonary Fibrosis Partly by Rescuing Alveolar Epithelial Cells From Senescence.
Zhang L, Tong X, Huang J, Wu M, Zhang S, Wang D, Liu S, Fan H
Frontiers in pharmacology 2020;11:553690
Frontiers in pharmacology 2020;11:553690
Hyperoside Attenuates Bleomycin-Induced Pulmonary Fibrosis Development in Mice.
Huang J, Tong X, Zhang L, Zhang Y, Wang L, Wang D, Zhang S, Fan H
Frontiers in pharmacology 2020;11:550955
Frontiers in pharmacology 2020;11:550955
Fibroblast Growth Factor 1 Ameliorates Diabetes-Induced Liver Injury by Reducing Cellular Stress and Restoring Autophagy.
Xu Z, Wu Y, Wang F, Li X, Wang P, Li Y, Wu J, Li Y, Jiang T, Pan X, Zhang X, Xie L, Xiao J, Liu Y
Frontiers in pharmacology 2020;11:52
Frontiers in pharmacology 2020;11:52
Scutellarein inhibits BLM-mediated pulmonary fibrosis by affecting fibroblast differentiation, proliferation, and apoptosis.
Miao K, Pan T, Mou Y, Zhang L, Xiong W, Xu Y, Yu J, Wang Y
Therapeutic advances in chronic disease 2020;11:2040622320940185
Therapeutic advances in chronic disease 2020;11:2040622320940185
GADD45B Promotes Glucose-Induced Renal Tubular Epithelial-Mesenchymal Transition and Apoptosis via the p38 MAPK and JNK Signaling Pathways.
Xue M, Sun H, Xu R, Wang Y, Guo J, Li X, Cheng Y, Xu C, Tang C, Sun B, Chen L
Frontiers in physiology 2020;11:1074
Frontiers in physiology 2020;11:1074
Salvia miltiorrhiza-derived miRNAs suppress vascular remodeling through regulating OTUD7B/KLF4/NMHC IIA axis.
Yang GS, Zheng B, Qin Y, Zhou J, Yang Z, Zhang XH, Zhao HY, Yang HJ, Wen JK
Theranostics 2020;10(17):7787-7811
Theranostics 2020;10(17):7787-7811
Aerosolized Thyroid Hormone Prevents Radiation Induced Lung Fibrosis.
Li L, Nie X, Yi M, Qin W, Li F, Wu B, Yuan X
Frontiers in oncology 2020;10:528686
Frontiers in oncology 2020;10:528686
The F-box protein FBXO11 restrains hepatocellular carcinoma stemness via promotion of ubiquitin-mediated degradation of Snail.
Shao L, Zhang X, Yao Q
FEBS open bio 2020 Sep;10(9):1810-1820
FEBS open bio 2020 Sep;10(9):1810-1820
Abnormal expression of homeobox c6 in the atherosclerotic aorta and its effect on proliferation and migration of rat vascular smooth muscle cells.
Long X, You G, Wu Q, Zhou Y, Yu F, Xiao Y, Deng S, Song F, Huang J, Tian M
Acta biochimica et biophysica Sinica 2020 Sep 8;52(9):935-943
Acta biochimica et biophysica Sinica 2020 Sep 8;52(9):935-943
Inhibition of p66Shc Oxidative Signaling via CA-Induced Upregulation of miR-203a-3p Alleviates Liver Fibrosis Progression.
Wang Z, Zhao Y, Zhao H, Zhou J, Feng D, Tang F, Li Y, Lv L, Chen Z, Ma X, Tian X, Yao J
Molecular therapy. Nucleic acids 2020 Sep 4;21:751-763
Molecular therapy. Nucleic acids 2020 Sep 4;21:751-763
Porphyromonas gingivalis disrupts vascular endothelial homeostasis in a TLR-NF-κB axis dependent manner.
Xie M, Tang Q, Yu S, Sun J, Mei F, Zhao J, Chen L
International journal of oral science 2020 Sep 30;12(1):28
International journal of oral science 2020 Sep 30;12(1):28
Salvianolic acid B and sodium tanshinone II A sulfonate prevent pulmonary fibrosis through anti-inflammatory and anti-fibrotic process.
Jiang L, Wang J, Ju J, Dai J
European journal of pharmacology 2020 Sep 15;883:173352
European journal of pharmacology 2020 Sep 15;883:173352
LncRNA Mical2/miR-203a-3p sponge participates in epithelial-mesenchymal transition by targeting p66Shc in liver fibrosis.
Zhao Y, Wang Z, Zhou J, Feng D, Li Y, Hu Y, Zhang F, Chen Z, Wang G, Ma X, Tian X, Yao J
Toxicology and applied pharmacology 2020 Sep 15;403:115125
Toxicology and applied pharmacology 2020 Sep 15;403:115125
Paired box 9 regulates VSMC phenotypic transformation, proliferation, and migration via sonic hedgehog.
Xu J, Zhang Y, You S, Guo Y, Chen S, Chang Y, Zhang N, Sun Y
Life sciences 2020 Sep 15;257:118053
Life sciences 2020 Sep 15;257:118053
CTRP15 derived from cardiac myocytes attenuates TGFβ1-induced fibrotic response in cardiac fibroblasts.
Zhao Q, Zhang CL, Xiang RL, Wu LL, Li L
Cardiovascular drugs and therapy 2020 Oct;34(5):591-604
Cardiovascular drugs and therapy 2020 Oct;34(5):591-604
Emodin inhibiting neutrophil elastase-induced epithelial-mesenchymal transition through Notch1 signalling in alveolar epithelial cells.
Zhou L, Gao R, Hong H, Li X, Yang J, Shen W, Wang Z, Yang J
Journal of cellular and molecular medicine 2020 Oct;24(20):11998-12007
Journal of cellular and molecular medicine 2020 Oct;24(20):11998-12007
Polydeoxyribonucleotide-delivering therapeutic hydrogel for diabetic wound healing.
Shin DY, Park JU, Choi MH, Kim S, Kim HE, Jeong SH
Scientific reports 2020 Oct 8;10(1):16811
Scientific reports 2020 Oct 8;10(1):16811
Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin.
Kawara A, Mizuta R, Fujisawa M, Ito T, Li C, Nakamura K, Sun C, Kuwabara M, Kitabatake M, Yoshimura T, Matsukawa A
Scientific reports 2020 Oct 5;10(1):16490
Scientific reports 2020 Oct 5;10(1):16490
IL-32 induces epithelial-mesenchymal transition by triggering endoplasmic reticulum stress in A549 cells.
Gong L, Liu G, Zhu H, Li C, Li P, Liu C, Tang H, Wu K, Wu J, Liu D, Tang X
BMC pulmonary medicine 2020 Oct 23;20(1):278
BMC pulmonary medicine 2020 Oct 23;20(1):278
P38 Inhibition Prevents Herpes Simplex Virus Type 1 (HSV-1) Infection in Cultured Corneal Keratocytes.
Xian-Kui H, Hui-Fang W, Jing-Ran S, Yu-Rong H, Bo-Yu C, Xiu-Jun S
Current eye research 2020 Nov;45(11):1342-1351
Current eye research 2020 Nov;45(11):1342-1351
Inhibition of microRNA-150-5p alleviates cardiac inflammation and fibrosis via targeting Smad7 in high glucose-treated cardiac fibroblasts.
Che H, Wang Y, Li Y, Lv J, Li H, Liu Y, Dong R, Sun Y, Xu X, Zhao J, Wang L
Journal of cellular physiology 2020 Nov;235(11):7769-7779
Journal of cellular physiology 2020 Nov;235(11):7769-7779
Cancer-associated fibroblasts induce epithelial-mesenchymal transition and cisplatin resistance in ovarian cancer via CXCL12/CXCR4 axis.
Zhang F, Cui JY, Gao HF, Yu H, Gao FF, Chen JL, Chen L
Future oncology (London, England) 2020 Nov;16(32):2619-2633
Future oncology (London, England) 2020 Nov;16(32):2619-2633
OXPHOS-dependent metabolic reprogramming prompts metastatic potential of breast cancer cells under osteogenic differentiation.
Hu Y, Xu W, Zeng H, He Z, Lu X, Zuo D, Qin G, Chen W
British journal of cancer 2020 Nov;123(11):1644-1655
British journal of cancer 2020 Nov;123(11):1644-1655
Depleting RhoA/Stress Fiber-Organized Fibronectin Matrices on Tumor Cells Non-Autonomously Aggravates Fibroblast-Driven Tumor Cell Growth.
Huang LT, Tsai CL, Huang SH, Chang MM, Chang WT, Cheng LH, Cheng HC
International journal of molecular sciences 2020 Nov 4;21(21)
International journal of molecular sciences 2020 Nov 4;21(21)
Sirtuin 6 attenuates epithelial-mesenchymal transition by suppressing the TGF-β1/Smad3 pathway and c-Jun in asthma models.
Liu F, Shang YX
International immunopharmacology 2020 May;82:106333
International immunopharmacology 2020 May;82:106333
Downregulation of lysyl oxidase in venous malformations: Association with vascular destabilization and sclerotherapy.
Zhu J, Shao M, Guo F, Ren J, Tang Z, Geng J, Xu Z, Jia J, Chen L, Jia Y
The Journal of dermatology 2020 May;47(5):518-526
The Journal of dermatology 2020 May;47(5):518-526
Generation and characterization of a human iPSC line derived from congenital clubfoot amniotic fluid cells.
Wang J, Cui Y, Xing K, Luan J, Han J
Stem cell research 2020 Mar;43:101712
Stem cell research 2020 Mar;43:101712
Upregulation of KSRP by miR-27b attenuates schistosomiasis-induced hepatic fibrosis by targeting TGF-β1.
Wang S, Li M, Zhao X, Wang H, Zhu J, Wang C, Zhou M, Dong H, Zhou R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4120-4133
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4120-4133
TSP-1 as a novel biological marker of tumor vasculature normalization in colon carcinoma induced by Endostar.
Yang W, Li W, Pan F, Yang XY, Zhao X, Qin L, Pan Y
Oncology letters 2020 Mar;19(3):2107-2114
Oncology letters 2020 Mar;19(3):2107-2114
The mechanism and role of intracellular α-ketoglutarate reduction in hepatic stellate cell activation.
Zhao J, Jiang Y, Sun X, Liu X, Liu F, Song M, Zhang L
Bioscience reports 2020 Mar 27;40(3)
Bioscience reports 2020 Mar 27;40(3)
LTBP1 promotes esophageal squamous cell carcinoma progression through epithelial-mesenchymal transition and cancer-associated fibroblasts transformation.
Cai R, Wang P, Zhao X, Lu X, Deng R, Wang X, Su Z, Hong C, Lin J
Journal of translational medicine 2020 Mar 26;18(1):139
Journal of translational medicine 2020 Mar 26;18(1):139
Ophiocordyceps lanpingensis polysaccharides attenuate pulmonary fibrosis in mice.
Zhou S, Zhou Y, Yu J, Du Y, Tan Y, Ke Y, Wang J, Han B, Ge F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jun;126:110058
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jun;126:110058
Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78).
Lei Q, Yi T, Li H, Yan Z, Lv Z, Li G, Wang Y
Scientific reports 2020 Jun 30;10(1):10604
Scientific reports 2020 Jun 30;10(1):10604
MiR-377-3p inhibits atherosclerosis-associated vascular smooth muscle cell proliferation and migration via targeting neuropilin2.
Wang H, Wei Z, Li H, Guan Y, Han Z, Wang H, Liu B
Bioscience reports 2020 Jun 26;40(6)
Bioscience reports 2020 Jun 26;40(6)
Exploring the potential of engineered exosomes as delivery systems for tumor-suppressor microRNA replacement therapy in ovarian cancer.
Kobayashi M, Sawada K, Miyamoto M, Shimizu A, Yamamoto M, Kinose Y, Nakamura K, Kawano M, Kodama M, Hashimoto K, Kimura T
Biochemical and biophysical research communications 2020 Jun 18;527(1):153-161
Biochemical and biophysical research communications 2020 Jun 18;527(1):153-161
LncRNA NNT-AS1 promote glioma cell proliferation and metastases through miR-494-3p/PRMT1 axis.
Zheng D, Chen D, Lin F, Wang X, Lu L, Luo S, Chen J, Xu X
Cell cycle (Georgetown, Tex.) 2020 Jul;19(13):1621-1631
Cell cycle (Georgetown, Tex.) 2020 Jul;19(13):1621-1631
Administration of a mixture of triterpenoids from yeyachun and phenolic acids from danshen ameliorates carbon tetrachloride-induced liver fibrosis in mice by the regulation of intestinal flora.
Tan Y, Li Y, Zhou F, Guo J, Wang T, Shi Y, Yang Y, Lu J, Pei G
Journal of pharmacological sciences 2020 Jul;143(3):165-175
Journal of pharmacological sciences 2020 Jul;143(3):165-175
Elk-1 transcriptionally regulates ZC3H4 expression to promote silica-induced epithelial-mesenchymal transition.
Jiang R, Gao Q, Chen M, Yu T
Laboratory investigation; a journal of technical methods and pathology 2020 Jul;100(7):959-973
Laboratory investigation; a journal of technical methods and pathology 2020 Jul;100(7):959-973
Tensile force-induced PDGF-BB/PDGFRβ signals in periodontal ligament fibroblasts activate JAK2/STAT3 for orthodontic tooth movement.
Jin Y, Ding L, Ding Z, Fu Y, Song Y, Jing Y, Li Q, Zhang J, Ni Y, Hu Q
Scientific reports 2020 Jul 9;10(1):11269
Scientific reports 2020 Jul 9;10(1):11269
Single-Cell Transcriptome Analysis Reveals Intratumoral Heterogeneity in ccRCC, which Results in Different Clinical Outcomes.
Hu J, Chen Z, Bao L, Zhou L, Hou Y, Liu L, Xiong M, Zhang Y, Wang B, Tao Z, Chen K
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Jul 8;28(7):1658-1672
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Jul 8;28(7):1658-1672
Nintedanib Reduces Neutrophil Chemotaxis via Activating GRK2 in Bleomycin-Induced Pulmonary Fibrosis.
Chen WC, Chen NJ, Chen HP, Yu WK, Su VY, Chen H, Wu HH, Yang KY
International journal of molecular sciences 2020 Jul 2;21(13)
International journal of molecular sciences 2020 Jul 2;21(13)
TIM-4 interference in Kupffer cells against CCL4-induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway.
Wu H, Chen G, Wang J, Deng M, Yuan F, Gong J
Cell proliferation 2020 Jan;53(1):e12731
Cell proliferation 2020 Jan;53(1):e12731
Subcellular trafficking of tubular MDM2 implicates in acute kidney injury to chronic kidney disease transition during multiple low-dose cisplatin exposure.
Su H, Ye C, Lei CT, Tang H, Zeng JY, Yi F, Zhang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1620-1636
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1620-1636
Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling.
Wang Y, Li C, Gu J, Chen C, Duanmu J, Miao J, Yao W, Tao J, Tu M, Xiong B, Zhao L, Liu Z
Journal of cellular and molecular medicine 2020 Jan;24(1):941-953
Journal of cellular and molecular medicine 2020 Jan;24(1):941-953
Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function.
Wang L, Yu P, Zhou B, Song J, Li Z, Zhang M, Guo G, Wang Y, Chen X, Han L, Hu S
Nature cell biology 2020 Jan;22(1):108-119
Nature cell biology 2020 Jan;22(1):108-119
Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation.
Chen Z, Sun X, Chen Q, Lan T, Huang K, Xiao H, Lin Z, Yang Y, Liu P, Huang H
British journal of pharmacology 2020 Jan;177(1):145-160
British journal of pharmacology 2020 Jan;177(1):145-160
Long non-coding RNA RNF7 promotes the cardiac fibrosis in rat model via miR-543/THBS1 axis and TGFβ1 activation.
Ouyang F, Liu X, Liu G, Qiu H, He Y, Hu H, Jiang P
Aging 2020 Jan 8;12(1):996-1010
Aging 2020 Jan 8;12(1):996-1010
Bleomycin induces epithelial-to-mesenchymal transition via bFGF/PI3K/ESRP1 signaling in pulmonary fibrosis.
Weng CM, Li Q, Chen KJ, Xu CX, Deng MS, Li T, Zhang DD, Duan ZX, Chen ZQ, Li GH, Chen J, Wang JM
Bioscience reports 2020 Jan 31;40(1)
Bioscience reports 2020 Jan 31;40(1)
Telmisartan inhibits oxalate and calcium oxalate crystal-induced epithelial-mesenchymal transformation via PPAR-γ-AKT/STAT3/p38 MAPK-Snail pathway.
Liu Y, Chen S, Liu J, Jin Y, Yu S, An R
Life sciences 2020 Jan 15;241:117108
Life sciences 2020 Jan 15;241:117108
Icariside II improves myocardial fibrosis in spontaneously hypertensive rats by inhibiting collagen synthesis.
Fu S, Li Y, Wu Y, Yue Y, Yang D
The Journal of pharmacy and pharmacology 2020 Feb;72(2):227-235
The Journal of pharmacy and pharmacology 2020 Feb;72(2):227-235
SWI/SNF complex subunit BAF60a represses hepatic ureagenesis through a crosstalk between YB-1 and PGC-1α.
Zhang W, Dong Z, Xu M, Zhang S, Liu C, Chen S
Molecular metabolism 2020 Feb;32:85-96
Molecular metabolism 2020 Feb;32:85-96
Role of WW domain E3 ubiquitin protein ligase 2 in modulating ubiquitination and Degradation of Septin4 in oxidative stress endothelial injury.
Zhang N, Zhang Y, Wu B, You S, Sun Y
Redox biology 2020 Feb;30:101419
Redox biology 2020 Feb;30:101419
Jiawei Yanghe decoction ameliorates cartilage degradation in vitro and vivo via Wnt/β-catenin signaling pathway.
Xia H, Cao D, Yang F, Yang W, Li W, Liu P, Wang S, Yang F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Feb;122:109708
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Feb;122:109708
Pluripotent hematopoietic stem cells augment α-adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension.
Hashimoto R, Lanier GM, Dhagia V, Joshi SR, Jordan A, Waddell I, Tuder R, Stenmark KR, Wolin MS, McMurtry IF, Gupte SA
American journal of physiology. Lung cellular and molecular physiology 2020 Feb 1;318(2):L386-L401
American journal of physiology. Lung cellular and molecular physiology 2020 Feb 1;318(2):L386-L401
Establishment of a control induced pluripotent stem cell line SMBCi006-A from a healthy male donor.
Shi L, Cui Y, Zhang G, Zhou X, Luan J, Han J
Stem cell research 2020 Dec;49:102025
Stem cell research 2020 Dec;49:102025
miR-448-3p alleviates diabetic vascular dysfunction by inhibiting endothelial-mesenchymal transition through DPP-4 dysregulation.
Guan GY, Wei N, Song T, Zhao C, Sun Y, Pan RX, Zhang LL, Xu YY, Dai YM, Han H
Journal of cellular physiology 2020 Dec;235(12):10024-10036
Journal of cellular physiology 2020 Dec;235(12):10024-10036
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications.
Zhao Y, Li M, Yao X, Fei Y, Lin Z, Li Z, Cai K, Zhao Y, Luo Z
Cell reports 2020 Dec 8;33(10):108487
Cell reports 2020 Dec 8;33(10):108487
Extracellular histones stimulate collagen expression in vitro and promote liver fibrogenesis in a mouse model via the TLR4-MyD88 signaling pathway.
Wang Z, Cheng ZX, Abrams ST, Lin ZQ, Yates ED, Yu Q, Yu WP, Chen PS, Toh CH, Wang GZ
World journal of gastroenterology 2020 Dec 21;26(47):7513-7527
World journal of gastroenterology 2020 Dec 21;26(47):7513-7527
β2-microglobulin as a biomarker of pulmonary fibrosis development in COPD patients.
Wu Z, Yan M, Zhang M, Wu N, Ma G, Wang B, Fan Y, Du X, Ding C, Liu Y
Aging 2020 Dec 21;13(1):1251-1263
Aging 2020 Dec 21;13(1):1251-1263
Apremilast interferes with the TGFβ1-induced transition of human skin fibroblasts into profibrotic myofibroblasts: in vitro study.
Cutolo M, Soldano S, Montagna P, Martinelli G, Tardito S, Corallo C, Giordano N, Tavilla P, Cozzani E, Parodi A, Sulli A, Pizzorni C, Patane M, Smith V, Paolino S
Rheumatology (Oxford, England) 2020 Dec 1;59(12):3927-3938
Rheumatology (Oxford, England) 2020 Dec 1;59(12):3927-3938
Silencing of the lncRNA TUG1 attenuates the epithelial-mesenchymal transition of renal tubular epithelial cells by sponging miR-141-3p via regulating β-catenin.
Zhang B, Zhao C, Hou L, Wu Y
American journal of physiology. Renal physiology 2020 Dec 1;319(6):F1125-F1134
American journal of physiology. Renal physiology 2020 Dec 1;319(6):F1125-F1134
LncRNA Gm16410 regulates PM(2.5)-induced lung Endothelial-Mesenchymal Transition via the TGF-β1/Smad3/p-Smad3 pathway.
Ma K, Li C, Xu J, Ren F, Xu X, Liu C, Niu B, Li F
Ecotoxicology and environmental safety 2020 Dec 1;205:111327
Ecotoxicology and environmental safety 2020 Dec 1;205:111327
Ammonia exposure causes lung injuries and disturbs pulmonary circadian clock gene network in a pig study.
Wang X, Wang M, Chen S, Wei B, Gao Y, Huang L, Liu C, Huang T, Yu M, Zhao SH, Li X
Ecotoxicology and environmental safety 2020 Dec 1;205:111050
Ecotoxicology and environmental safety 2020 Dec 1;205:111050
Atorvastatin attenuates TGF‑β1‑induced fibrogenesis by inhibiting Smad3 and MAPK signaling in human ventricular fibroblasts.
Du Y, Xiao H, Wan J, Wang X, Li T, Zheng S, Feng J, Ye Q, Li J, Li G, Fan Z
International journal of molecular medicine 2020 Aug;46(2):633-640
International journal of molecular medicine 2020 Aug;46(2):633-640
Maladjustment of β-CGRP/α-CGRP Regulation of AQP5 Promotes Transition of Alveolar Epithelial Cell Apoptosis to Pulmonary Fibrosis.
Lv X, Gao F, Zhang S, Zhang S, Zhou X, Ding F, Wang J, Chen Q, Chen M, Liu Q
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2020 Aug;40(8):377-388
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2020 Aug;40(8):377-388
WWP2 regulates SIRT1-STAT3 acetylation and phosphorylation involved in hypertensive angiopathy.
Zhang Y, You S, Tian Y, Lu S, Cao L, Sun Y, Zhang N
Journal of cellular and molecular medicine 2020 Aug;24(16):9041-9054
Journal of cellular and molecular medicine 2020 Aug;24(16):9041-9054
Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoholic fatty liver disease by up-regulating the FGF21/PGC-1α pathway.
Wu L, Mo W, Feng J, Li J, Yu Q, Li S, Zhang J, Chen K, Ji J, Dai W, Wu J, Xu X, Mao Y, Guo C
British journal of pharmacology 2020 Aug;177(16):3760-3777
British journal of pharmacology 2020 Aug;177(16):3760-3777
Icotinib Attenuates Monocrotaline-Induced Pulmonary Hypertension by Preventing Pulmonary Arterial Smooth Muscle Cell Dysfunction.
Peng LY, Yu M, Yang MX, Liu P, Zhou H, Huang W, Kong H, Xie WP
American journal of hypertension 2020 Aug 4;33(8):775-783
American journal of hypertension 2020 Aug 4;33(8):775-783
Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease.
Sun B, Wang X, Liu X, Wang L, Ren F, Wang X, Leng X
Antioxidants (Basel, Switzerland) 2020 Aug 25;9(9)
Antioxidants (Basel, Switzerland) 2020 Aug 25;9(9)
Trichostatin A Alleviates Renal Interstitial Fibrosis Through Modulation of the M2 Macrophage Subpopulation.
Tseng WC, Tsai MT, Chen NJ, Tarng DC
International journal of molecular sciences 2020 Aug 19;21(17)
International journal of molecular sciences 2020 Aug 19;21(17)
Regulation of NLRP3 inflammasome by CD38 through cADPR-mediated Ca(2+) release in vascular smooth muscle cells in diabetic mice.
Li JP, Wei W, Li XX, Xu M
Life sciences 2020 Aug 15;255:117758
Life sciences 2020 Aug 15;255:117758
Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-β1/Smads signaling in diabetic cardiomyopathy.
Che H, Wang Y, Li H, Li Y, Sahil A, Lv J, Liu Y, Yang Z, Dong R, Xue H, Wang L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5282-5298
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5282-5298
Icariside II attenuates eosinophils-induced airway inflammation and remodeling via inactivation of NF-κB and STAT3 in an asthma mouse model.
Tian C, Gao F, Li X, Li Z
Experimental and molecular pathology 2020 Apr;113:104373
Experimental and molecular pathology 2020 Apr;113:104373
Activation of Sigma-1 Receptor Enhanced Pericyte Survival via the Interplay Between Apoptosis and Autophagy: Implications for Blood-Brain Barrier Integrity in Stroke.
Zhang Y, Zhang X, Wei Q, Leng S, Li C, Han B, Bai Y, Zhang H, Yao H
Translational stroke research 2020 Apr;11(2):267-287
Translational stroke research 2020 Apr;11(2):267-287
Micro-vesicles from mesenchymal stem cells over-expressing miR-34a inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells in vitro.
He J, Jiang YL, Wang Y, Tian XJ, Sun SR
Chinese medical journal 2020 Apr 5;133(7):800-807
Chinese medical journal 2020 Apr 5;133(7):800-807
The metastatic phenotype shift toward myofibroblast of adipose-derived mesenchymal stem cells promotes ovarian cancer progression.
Tang H, Chu Y, Huang Z, Cai J, Wang Z
Carcinogenesis 2020 Apr 22;41(2):182-193
Carcinogenesis 2020 Apr 22;41(2):182-193
Exosomal miR-125a-5p derived from silica-exposed macrophages induces fibroblast transdifferentiation.
Wang D, Hao C, Zhang L, Zhang J, Liu S, Li Y, Qu Y, Zhao Y, Huang R, Wei J, Yao W
Ecotoxicology and environmental safety 2020 Apr 1;192:110253
Ecotoxicology and environmental safety 2020 Apr 1;192:110253
Abnormal Ribosome Biogenesis Partly Induced p53-Dependent Aortic Medial Smooth Muscle Cell Apoptosis and Oxidative Stress.
Wu Q, Hong J, Wang Z, Hu J, Chen R, Hu Z, Li B, Hu X, Zhang Z, Ruan Y
Oxidative medicine and cellular longevity 2019;2019:7064319
Oxidative medicine and cellular longevity 2019;2019:7064319
Bufei Qingyu Granules Inhibit the Development of Systemic Sclerosis via Notch-1/Jagged-2 Signaling Pathway.
Su M, Tian F, Ouyang B, Wu X, Guo F, Chen H, Zhu X, Chen J, Qian X
Evidence-based complementary and alternative medicine : eCAM 2019;2019:6709278
Evidence-based complementary and alternative medicine : eCAM 2019;2019:6709278
Methane-Rich Saline Counteracts Cholestasis-Induced Liver Damage via Regulating the TLR4/NF-κB/NLRP3 Inflammasome Pathway.
Li Z, Chen D, Jia Y, Feng Y, Wang C, Tong Y, Cui R, Qu K, Liu C, Zhang J
Oxidative medicine and cellular longevity 2019;2019:6565283
Oxidative medicine and cellular longevity 2019;2019:6565283
Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways.
Liu N, Feng J, Lu X, Yao Z, Liu Q, Lv Y, Han Y, Deng J, Zhou Y
Mediators of inflammation 2019;2019:6175091
Mediators of inflammation 2019;2019:6175091
Effects of Ethyl Pyruvate on Bile Duct Ligation-Induced Liver Fibrosis by Regulating Nrf2 Pathway and Proinflammatory Cytokines in Rats.
Zong Y, Zhang M, Li S, Qi W, Li J, Liu T, Yang H, Lu C, Hu X
Gastroenterology research and practice 2019;2019:2969802
Gastroenterology research and practice 2019;2019:2969802
Human colorectal cancer-derived carcinoma associated fibroblasts promote CD44-mediated adhesion of colorectal cancer cells to endothelial cells by secretion of HGF.
Zhang R, Qi F, Shao S, Li G, Feng Y
Cancer cell international 2019;19:192
Cancer cell international 2019;19:192
Exosomal miRNA-139 in cancer-associated fibroblasts inhibits gastric cancer progression by repressing MMP11 expression.
Xu G, Zhang B, Ye J, Cao S, Shi J, Zhao Y, Wang Y, Sang J, Yao Y, Guan W, Tao J, Feng M, Zhang W
International journal of biological sciences 2019;15(11):2320-2329
International journal of biological sciences 2019;15(11):2320-2329
Fructose-1,6-bisphosphate prevents pulmonary fibrosis by regulating extracellular matrix deposition and inducing phenotype reversal of lung myofibroblasts.
Dias HB, de Oliveira JR, Donadio MVF, Kimura S
PloS one 2019;14(9):e0222202
PloS one 2019;14(9):e0222202
High-Mobility Group Box 1 Contributes to Cerebral Cortex Injury in a Neonatal Hypoxic-Ischemic Rat Model by Regulating the Phenotypic Polarization of Microglia.
Sun Y, Hei M, Fang Z, Tang Z, Wang B, Hu N
Frontiers in cellular neuroscience 2019;13:506
Frontiers in cellular neuroscience 2019;13:506
Liraglutide Improves Non-Alcoholic Fatty Liver Disease In Diabetic Mice By Modulating Inflammatory Signaling Pathways.
Luo Y, Yang P, Li Z, Luo Y, Shen J, Li R, Zheng H, Liang Y, Xia N
Drug design, development and therapy 2019;13:4065-4074
Drug design, development and therapy 2019;13:4065-4074
Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/MyD88/NF-κB signaling pathway.
Shao Q, Jiang C, Xia Y, Zhao M, Zhang Q, Jin B, Liu J
International journal of clinical and experimental pathology 2019;12(3):867-875
International journal of clinical and experimental pathology 2019;12(3):867-875
GPX2 suppression of H(2)O(2) stress regulates cervical cancer metastasis and apoptosis via activation of the β-catenin-WNT pathway.
Wang Y, Cao P, Alshwmi M, Jiang N, Xiao Z, Jiang F, Gu J, Wang X, Sun X, Li S
OncoTargets and therapy 2019;12:6639-6651
OncoTargets and therapy 2019;12:6639-6651
Liraglutide ameliorates nonalcoholic fatty liver disease in diabetic mice via the IRS2/PI3K/Akt signaling pathway.
Yang P, Liang Y, Luo Y, Li Z, Wen Y, Shen J, Li R, Zheng H, Gu HF, Xia N
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:1013-1021
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:1013-1021
Antiproliferative and Immunoregulatory Effects of Azelaic Acid Against Acute Myeloid Leukemia via the Activation of Notch Signaling Pathway.
Dongdong Z, Jin Y, Yang T, Yang Q, Wu B, Chen Y, Luo Z, Liang L, Liu Y, Xu A, Tong X, Can C, Ding L, Tu H, Tan Y, Jiang H, Liu X, Shen H, Liu L, Pan Y, Wei Y, Zhou F
Frontiers in pharmacology 2019;10:1396
Frontiers in pharmacology 2019;10:1396
Differential regulation of vacuolar H(+) -ATPase subunits by transforming growth factor-β1 in salivary ducts.
Kluge M, Namkoong E, Khakipoor S, Park K, Roussa E
Journal of cellular physiology 2019 Sep;234(9):15061-15079
Journal of cellular physiology 2019 Sep;234(9):15061-15079
The Akt/FoxO/p27(Kip1) axis contributes to the anti-proliferation of pentoxifylline in hypertrophic scars.
Yang F, Chen E, Yang Y, Han F, Han S, Wu G, Zhang M, Zhang J, Han J, Su L, Hu D
Journal of cellular and molecular medicine 2019 Sep;23(9):6164-6172
Journal of cellular and molecular medicine 2019 Sep;23(9):6164-6172
Adenovirus‑mediated overexpression of bone morphogenetic protein‑9 promotes methionine choline deficiency‑induced non‑alcoholic steatohepatitis in non‑obese mice.
Li Q, Liu B, Breitkopf-Heinlein K, Weng H, Jiang Q, Dong P, Dooley S, Xu K, Ding H
Molecular medicine reports 2019 Sep;20(3):2743-2753
Molecular medicine reports 2019 Sep;20(3):2743-2753
Downregulating SynCAM and MPP6 expression is associated with ovarian cancer progression.
Xu F, Si X, Du J, Xu F, Yang A, Zhang C, Zhang X, Yang Y
Oncology letters 2019 Sep;18(3):2477-2483
Oncology letters 2019 Sep;18(3):2477-2483
Exogenous angiotensin (1-7) directly inhibits epithelial-mesenchymal transformation induced by transforming growth factor-β1 in alveolar epithelial cells.
Shao M, Wen ZB, Yang HH, Zhang CY, Xiong JB, Guan XX, Zhong WJ, Jiang HL, Sun CC, Luo XQ, He XF, Zhou Y, Guan CX
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109193
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109193
A novel technique to prepare a single cell suspension of isolated quiescent human hepatic stellate cells.
Zhai X, Wang W, Dou D, Ma Y, Gang D, Jiang Z, Shi B, Jin B
Scientific reports 2019 Sep 4;9(1):12757
Scientific reports 2019 Sep 4;9(1):12757
Altered bile acid composition and disposition in a mouse model of non-alcoholic steatohepatitis.
Suga T, Yamaguchi H, Ogura J, Shoji S, Maekawa M, Mano N
Toxicology and applied pharmacology 2019 Sep 15;379:114664
Toxicology and applied pharmacology 2019 Sep 15;379:114664
Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure.
Xu B, Lang L, Li S, Yuan J, Wang J, Yang H, Lian S
Animals : an open access journal from MDPI 2019 Sep 14;9(9)
Animals : an open access journal from MDPI 2019 Sep 14;9(9)
Chrysophanol attenuates airway inflammation and remodeling through nuclear factor-kappa B signaling pathway in asthma.
Song G, Zhang Y, Yu S, Lv W, Guan Z, Sun M, Wang J
Phytotherapy research : PTR 2019 Oct;33(10):2702-2713
Phytotherapy research : PTR 2019 Oct;33(10):2702-2713
Inhibition of vascular neointima hyperplasia by FGF21 associated with FGFR1/Syk/NLRP3 inflammasome pathway in diabetic mice.
Wei W, Li XX, Xu M
Atherosclerosis 2019 Oct;289:132-142
Atherosclerosis 2019 Oct;289:132-142
Effects of ubiquitin-proteasome inhibitor on the expression levels of TNF-α and TGF-β1 in mice with viral myocarditis.
Zhang H, Yu J, Sun H, Zhao Y, Wang J, Zhang J, Meng B
Experimental and therapeutic medicine 2019 Oct;18(4):2799-2804
Experimental and therapeutic medicine 2019 Oct;18(4):2799-2804
SPIO nanoparticle-labeled bone marrow mesenchymal stem cells inhibit pulmonary EndoMT induced by SiO(2).
Jiang R, Liao Y, Yang F, Cheng Y, Dai X, Chao J
Experimental cell research 2019 Oct 1;383(1):111492
Experimental cell research 2019 Oct 1;383(1):111492
Curcumin mitigates the epithelial-to-mesenchymal transition in biliary epithelial cells through upregulating CD109 expression.
Fan J, Wang Q, Zhang Z, Sun L
Drug development research 2019 Nov;80(7):992-999
Drug development research 2019 Nov;80(7):992-999
Long non-coding RNA TUG1 promotes airway remodelling by suppressing the miR-145-5p/DUSP6 axis in cigarette smoke-induced COPD.
Gu W, Yuan Y, Wang L, Yang H, Li S, Tang Z, Li Q
Journal of cellular and molecular medicine 2019 Nov;23(11):7200-7209
Journal of cellular and molecular medicine 2019 Nov;23(11):7200-7209
[Exogenous hydrogen sulfide improves erectile dysfunction by inhibiting apoptosis of corpus cavernosum smooth muscle cells in rats with cavernous nerve injury].
Zeng Q, He S, Zhong L, Wang L, Cheng F, Zhang H, Hui J, Wei A
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2019 Nov 30;39(11):1329-1336
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2019 Nov 30;39(11):1329-1336
Artemisinin attenuates the development of atherosclerotic lesions by the regulation of vascular smooth muscle cell phenotype switching.
Du H, Zhao Q, Zang H, Chang C, Li X
Life sciences 2019 Nov 15;237:116943
Life sciences 2019 Nov 15;237:116943
SPARC induces phenotypic modulation of human brain vascular smooth muscle cells via AMPK/mTOR-mediated autophagy.
Li T, Tan X, Zhu S, Zhong W, Huang B, Sun J, Li F, Wang Y
Neuroscience letters 2019 Nov 1;712:134485
Neuroscience letters 2019 Nov 1;712:134485
Emergence of the Dedifferentiated Phenotype in Hepatocyte-Derived Tumors in Mice: Roles of Oncogene-Induced Epigenetic Alterations.
Watanabe K, Yamamoto M, Xin B, Ooshio T, Goto M, Fujii K, Liu Y, Okada Y, Furukawa H, Nishikawa Y
Hepatology communications 2019 May;3(5):697-715
Hepatology communications 2019 May;3(5):697-715
Inhibition of mitochondrial complex I activity attenuates neointimal hyperplasia by inhibiting smooth muscle cell proliferation and migration.
Yin J, Xia W, Wu M, Zhang Y, Huang S, Zhang A, Jia Z
Chemico-biological interactions 2019 May 1;304:73-82
Chemico-biological interactions 2019 May 1;304:73-82
Histone deacetylase-1 as a prognostic factor and mediator of gastric cancer progression by enhancing glycolysis.
Jiang Z, Yang H, Zhang X, Wang Z, Rong R, Wang X
Human pathology 2019 Mar;85:194-201
Human pathology 2019 Mar;85:194-201
NAB 2-Expressing Cancer-Associated Fibroblast Promotes HNSCC Progression.
Choi SY, Oh SY, Kang SH, Kang SM, Kim J, Lee HJ, Kwon TG, Kim JW, Hong SH
Cancers 2019 Mar 19;11(3)
Cancers 2019 Mar 19;11(3)
Ribes diacanthum Pall (RDP) ameliorates UUO-induced renal fibrosis via both canonical and non-canonical TGF-β signaling pathways in mice.
Gu L, Wang Y, Yang G, Tilyek A, Zhang C, Li S, Yu B, Chai C, Cao Z
Journal of ethnopharmacology 2019 Mar 1;231:302-310
Journal of ethnopharmacology 2019 Mar 1;231:302-310
AKR1B10 (Aldo-keto reductase family 1 B10) promotes brain metastasis of lung cancer cells in a multi-organ microfluidic chip model.
Liu W, Song J, Du X, Zhou Y, Li Y, Li R, Lyu L, He Y, Hao J, Ben J, Wang W, Shi H, Wang Q
Acta biomaterialia 2019 Jun;91:195-208
Acta biomaterialia 2019 Jun;91:195-208
Isolation and culture of vascular smooth muscle cells from rat placenta.
He C, Wang M, Yan Z, Zhang S, Liu H
Journal of cellular physiology 2019 Jun;234(6):7675-7682
Journal of cellular physiology 2019 Jun;234(6):7675-7682
Death-associated protein kinase 3 deficiency alleviates vascular calcification via AMPK-mediated inhibition of endoplasmic reticulum stress.
Li KX, Du Q, Wang HP, Sun HJ
European journal of pharmacology 2019 Jun 5;852:90-98
European journal of pharmacology 2019 Jun 5;852:90-98
Epidural adipose tissue-derived mesenchymal stem cell activation induced by lung cancer cells promotes malignancy and EMT of lung cancer.
Wang Y, Chu Y, Ren X, Xiang H, Xi Y, Ma X, Zhu K, Guo Z, Zhou C, Zhang G, Chen B
Stem cell research & therapy 2019 Jun 13;10(1):168
Stem cell research & therapy 2019 Jun 13;10(1):168
The emerging roles of a novel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial to mesenchymal transition.
Jiang R, Zhou Z, Liao Y, Yang F, Cheng Y, Huang J, Wang J, Chen H, Zhu T, Chao J
Toxicology letters 2019 Jun 1;307:26-40
Toxicology letters 2019 Jun 1;307:26-40
Beclin 1, LC3, and p62 expression in paraquat-induced pulmonary fibrosis.
Xu G, Wang X, Yu H, Wang C, Liu Y, Zhao R, Zhang G
Human & experimental toxicology 2019 Jul;38(7):794-802
Human & experimental toxicology 2019 Jul;38(7):794-802
c‑Jun N‑terminal kinase/transforming growth factor‑β/Smad3 pathway: Is it associated with endoplasmic reticulum stress‑mediated renal interstitial fibrosis?
Liu Y, Shen P, Zhou Y, Tang L, Chai H
Molecular medicine reports 2019 Jul;20(1):755-762
Molecular medicine reports 2019 Jul;20(1):755-762
miR-205-5p suppresses pulmonary vascular smooth muscle cell proliferation by targeting MICAL2-mediated Erk1/2 signaling.
Tao W, Sun W, Zhu H, Zhang J
Microvascular research 2019 Jul;124:43-50
Microvascular research 2019 Jul;124:43-50
Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.
Sun Z, Liu Y, Yu F, Xu Y, Yanli L, Liu N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108933
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108933
HBOA ameliorates CCl(4)-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways.
Sun X, Huang X, Zhu X, Liu L, Mo S, Wang H, Wei X, Lu S, Bai F, Wang D, Lin X, Lin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108901
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108901
Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro.
Yang Y, Chen S, Tao L, Gan S, Luo H, Xu Y, Shen X
Medical science monitor : international medical journal of experimental and clinical research 2019 Jul 20;25:5375-5388
Medical science monitor : international medical journal of experimental and clinical research 2019 Jul 20;25:5375-5388
Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α Inhibits Vascular Calcification Through Sirtuin 3-Mediated Reduction of Mitochondrial Oxidative Stress.
Feng H, Wang JY, Yu B, Cong X, Zhang WG, Li L, Liu LM, Zhou Y, Zhang CL, Gu PL, Wu LL
Antioxidants & redox signaling 2019 Jul 1;31(1):75-91
Antioxidants & redox signaling 2019 Jul 1;31(1):75-91
Rhynchophylline attenuates allergic bronchial asthma by inhibiting transforming growth factor-β1-mediated Smad and mitogen-activated protein kinase signaling transductions in vivo and in vitro.
Wang M, Li H, Zhao Y, Lv C, Zhou G
Experimental and therapeutic medicine 2019 Jan;17(1):251-259
Experimental and therapeutic medicine 2019 Jan;17(1):251-259
CDH11 promotes liver fibrosis via activation of hepatic stellate cells.
Ruan W, Pan R, Shen X, Nie Y, Wu Y
Biochemical and biophysical research communications 2019 Jan 8;508(2):543-549
Biochemical and biophysical research communications 2019 Jan 8;508(2):543-549
The deregulation of STIM1 and store operative calcium entry impaired aortic smooth muscle cells contractility in aortic medial degeneration.
Hong J, Hu Z, Wu Q, Tang C, Hu J, Chen R, Li B, Wang Z
Bioscience reports 2019 Jan 31;39(1)
Bioscience reports 2019 Jan 31;39(1)
Anti-senescence role of heterozygous fumarate hydratase gene knockout in rat lung fibroblasts in vitro.
Fan Z, Li L, Li X, Zhang M, Dou M, Zhao J, Cao J, Deng X, Zhang M, Li H, Suo Z
Aging 2019 Jan 21;11(2):573-589
Aging 2019 Jan 21;11(2):573-589
Native nanodiscs from blood inhibit pulmonary fibrosis.
Sun A, Lai Z, Zhao M, Mu L, Hu X
Biomaterials 2019 Feb;192:51-61
Biomaterials 2019 Feb;192:51-61
Autophagic flux blockage in alveolar epithelial cells is essential in silica nanoparticle-induced pulmonary fibrosis.
Zhao X, Wei S, Li Z, Lin C, Zhu Z, Sun D, Bai R, Qian J, Gao X, Chen G, Xu Z
Cell death & disease 2019 Feb 12;10(2):127
Cell death & disease 2019 Feb 12;10(2):127
Indoxyl sulfate-induced calcification of vascular smooth muscle cells via the PI3K/Akt/NF-κB signaling pathway.
He X, Jiang H, Gao F, Liang S, Wei M, Chen L
Microscopy research and technique 2019 Dec;82(12):2000-2006
Microscopy research and technique 2019 Dec;82(12):2000-2006
miR-194 suppresses epithelial-mesenchymal transition of retinal pigment epithelial cells by directly targeting ZEB1.
Cui L, Lyu Y, Jin X, Wang Y, Li X, Wang J, Zhang J, Deng Z, Yang N, Zheng Z, Guo Y, Wang C, Mao R, Xu J, Gao F, Jin C, Zhang J, Tian H, Xu GT, Lu L
Annals of translational medicine 2019 Dec;7(23):751
Annals of translational medicine 2019 Dec;7(23):751
Label- and modification-free-based in situ selection of bovine serum albumin specific aptamer.
Wang C, Du X, Xie T, Li H
Journal of separation science 2019 Dec;42(23):3571-3578
Journal of separation science 2019 Dec;42(23):3571-3578
Knockdown of periostin attenuates 5/6 nephrectomy-induced intrarenal renin-angiotensin system activation, fibrosis, and inflammation in rats.
Bian X, Bai Y, Su X, Zhao G, Sun G, Li D
Journal of cellular physiology 2019 Dec;234(12):22857-22873
Journal of cellular physiology 2019 Dec;234(12):22857-22873
circPUM1 Promotes Tumorigenesis and Progression of Ovarian Cancer by Sponging miR-615-5p and miR-6753-5p.
Guan X, Zong ZH, Liu Y, Chen S, Wang LL, Zhao Y
Molecular therapy. Nucleic acids 2019 Dec 6;18:882-892
Molecular therapy. Nucleic acids 2019 Dec 6;18:882-892
Salusin-β Promotes Vascular Calcification via Nicotinamide Adenine Dinucleotide Phosphate/Reactive Oxygen Species-Mediated Klotho Downregulation.
Sun H, Zhang F, Xu Y, Sun S, Wang H, Du Q, Gu C, Black SM, Han Y, Tang H
Antioxidants & redox signaling 2019 Dec 20;31(18):1352-1370
Antioxidants & redox signaling 2019 Dec 20;31(18):1352-1370
Galectin-3 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension.
Li T, Zha L, Luo H, Li S, Zhao L, He J, Li X, Qi Q, Liu Y, Yu Z
Aging and disease 2019 Aug;10(4):731-745
Aging and disease 2019 Aug;10(4):731-745
Calhex(231) Alleviates High Glucose-Induced Myocardial Fibrosis via Inhibiting Itch-Ubiquitin Proteasome Pathway in Vitro.
Yuan H, Xu J, Xu X, Gao T, Wang Y, Fan Y, Hu J, Shao Y, Zhao B, Li H, Sun J, Xu C
Biological & pharmaceutical bulletin 2019 Aug 1;42(8):1337-1344
Biological & pharmaceutical bulletin 2019 Aug 1;42(8):1337-1344
Expression and distribution of PIEZO1 in the mouse urinary tract.
Dalghi MG, Clayton DR, Ruiz WG, Al-Bataineh MM, Satlin LM, Kleyman TR, Ricke WA, Carattino MD, Apodaca G
American journal of physiology. Renal physiology 2019 Aug 1;317(2):F303-F321
American journal of physiology. Renal physiology 2019 Aug 1;317(2):F303-F321
Exploring the Mechanism of Dangguiliuhuang Decoction Against Hepatic Fibrosis by Network Pharmacology and Experimental Validation.
Cao H, Li S, Xie R, Xu N, Qian Y, Chen H, Hu Q, Quan Y, Yu Z, Liu J, Xiang M
Frontiers in pharmacology 2018;9:187
Frontiers in pharmacology 2018;9:187
Salvianolic Acid A Attenuates Endoplasmic Reticulum Stress and Protects Against Cholestasis-Induced Liver Fibrosis via the SIRT1/HSF1 Pathway.
Zhu J, Wang R, Xu T, Zhang S, Zhao Y, Li Z, Wang C, Zhou J, Gao D, Hu Y, Tian X, Yao J
Frontiers in pharmacology 2018;9:1277
Frontiers in pharmacology 2018;9:1277
Monitoring the Process of Endostar-Induced Tumor Vascular Normalization by Non-contrast Intravoxel Incoherent Motion Diffusion-Weighted MRI.
Pan JH, Zhu S, Huang J, Liang J, Zhang D, Zhao X, Ding H, Qin L, Shi C, Luo L, Pan Y
Frontiers in oncology 2018;8:524
Frontiers in oncology 2018;8:524
Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2.
He FF, You RY, Ye C, Lei CT, Tang H, Su H, Zhang C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(2):451-460
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(2):451-460
Glucagon-Like Peptide-1 Mediates the Protective Effect of the Dipeptidyl Peptidase IV Inhibitor on Renal Fibrosis via Reducing the Phenotypic Conversion of Renal Microvascular Cells in Monocrotaline-Treated Rats.
Xu J, Wang J, Cheng Y, Li X, He M, Zhu J, Han H, Wei G, Kong H, Xie W, Wang H, Zuo X
BioMed research international 2018;2018:1864107
BioMed research international 2018;2018:1864107
Engagement of circular RNA HECW2 in the nonautophagic role of ATG5 implicated in the endothelial-mesenchymal transition.
Yang L, Han B, Zhang Y, Bai Y, Chao J, Hu G, Yao H
Autophagy 2018;14(3):404-418
Autophagy 2018;14(3):404-418
Zoledronate inhibits fibroblasts' proliferation and activation via targeting TGF-β signaling pathway.
Zhao Z, Shen W, Zhu H, Lin L, Jiang G, Zhu Y, Song H, Wu L
Drug design, development and therapy 2018;12:3021-3031
Drug design, development and therapy 2018;12:3021-3031
Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways.
Feng J, Chen K, Xia Y, Wu L, Li J, Li S, Wang W, Lu X, Liu T, Guo C
Drug design, development and therapy 2018;12:1837-1853
Drug design, development and therapy 2018;12:1837-1853
EDIL3 depletion suppress epithelial-mesenchymal transition of lens epithelial cells via transforming growth factor β pathway.
Zhang R, Wei YH, Zhao CY, Song HY, Shen N, Cui X, Gao X, Qi ZT, Zhong M, Shen W
International journal of ophthalmology 2018;11(1):18-24
International journal of ophthalmology 2018;11(1):18-24
Thymosin β4 suppresses CCl(4) -induced murine hepatic fibrosis by down-regulating transforming growth factor β receptor-II.
Li H, Li Q, Zhang X, Zheng X, Zhang Q, Hao Z
The journal of gene medicine 2018 Sep;20(9):e3043
The journal of gene medicine 2018 Sep;20(9):e3043
Stromal expression of JNK1 and VDR is associated with the prognosis of esophageal squamous cell carcinoma.
Bao Y, Zhang S, Guo Y, Wei X, Zhang Y, Yang Y, Zhang H, Ma M, Yang W
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2018 Sep;20(9):1185-1195
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2018 Sep;20(9):1185-1195
Anterior gradient 2 as a supervisory marker for tumor vessel normalization induced by anti-angiogenic treatment.
Pan F, Li W, Yang W, Yang XY, Liu S, Li X, Zhao X, Ding H, Qin L, Pan Y
Oncology letters 2018 Sep;16(3):3083-3091
Oncology letters 2018 Sep;16(3):3083-3091
Rab7 empowers renal tubular epithelial cells with autophagy-mediated protection against albumin-induced injury.
Liu L, Li Y, Wang Z, Ding F, Cheng Z, Xu Q, Cai Y, Limbu MH, Yang Y, Liu B, Chen P
Experimental cell research 2018 Sep 15;370(2):198-207
Experimental cell research 2018 Sep 15;370(2):198-207
NMDA receptor activation inhibits the antifibrotic effect of BM-MSCs on bleomycin-induced pulmonary fibrosis.
Li X, Li C, Tang Y, Huang Y, Cheng Q, Huang X, Zhao F, Hao C, Feng D, Xu J, Han J, Tang S, Liu W, Yue S, Luo Z
American journal of physiology. Lung cellular and molecular physiology 2018 Sep 1;315(3):L404-L421
American journal of physiology. Lung cellular and molecular physiology 2018 Sep 1;315(3):L404-L421
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Ning C, Gao X, Wang C, Kong Y, Liu Z, Sun H, Sun P, Huo X, Ma X, Meng Q, Liu K
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Octreotide attenuates hepatic fibrosis and hepatic stellate cells proliferation and activation by inhibiting Wnt/β-catenin signaling pathway, c-Myc and cyclin D1.
Zhang C, Liu XQ, Sun HN, Meng XM, Bao YW, Zhang HP, Pan FM, Zhang C
International immunopharmacology 2018 Oct;63:183-190
International immunopharmacology 2018 Oct;63:183-190
LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis.
Zhu P, Wu J, Wang Y, Zhu X, Lu T, Liu B, He L, Ye B, Wang S, Meng S, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y, Fan Z
Nature cell biology 2018 Oct;20(10):1134-1144
Nature cell biology 2018 Oct;20(10):1134-1144
Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells.
Song S, Qiu D, Luo F, Wei J, Wu M, Wu H, Du C, Du Y, Ren Y, Chen N, Duan H, Shi Y
Journal of molecular endocrinology 2018 Oct 1;61(3):101-113
Journal of molecular endocrinology 2018 Oct 1;61(3):101-113
Hepatoprotection of auraptene from peels of citrus fruits against thioacetamide-induced hepatic fibrosis in mice by activating farnesoid X receptor.
Gao X, Wang C, Ning C, Liu K, Wang X, Liu Z, Sun H, Ma X, Sun P, Meng Q
Food & function 2018 May 23;9(5):2684-2694
Food & function 2018 May 23;9(5):2684-2694
Rotenone ameliorates chronic renal injury caused by acute ischemia/reperfusion.
Zhang W, Sha Y, Wei K, Wu C, Ding D, Yang Y, Zhu C, Zhang Y, Ding G, Zhang A, Jia Z, Huang S
Oncotarget 2018 May 11;9(36):24199-24208
Oncotarget 2018 May 11;9(36):24199-24208
circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1.
Fang S, Guo H, Cheng Y, Zhou Z, Zhang W, Han B, Luo W, Wang J, Xie W, Chao J
Cell death & disease 2018 Mar 14;9(3):396
Cell death & disease 2018 Mar 14;9(3):396
Propranolol prevents liver cirrhosis by inhibiting hepatic stellate cell activation mediated by the PDGFR/Akt pathway.
Ding Q, Li Z, Liu B, Ling L, Tian X, Zhang C
Human pathology 2018 Jun;76:37-46
Human pathology 2018 Jun;76:37-46
Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis.
Liu Z, Zhu P, Zhang L, Xiong B, Tao J, Guan W, Li C, Chen C, Gu J, Duanmu J, Zhang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:1262-1271
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:1262-1271
Taurocholic acid is an active promoting factor, not just a biomarker of progression of liver cirrhosis: evidence from a human metabolomic study and in vitro experiments.
Liu Z, Zhang Z, Huang M, Sun X, Liu B, Guo Q, Chang Q, Duan Z
BMC gastroenterology 2018 Jul 11;18(1):112
BMC gastroenterology 2018 Jul 11;18(1):112
Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity.
Bai Y, Zhang Y, Han B, Yang L, Chen X, Huang R, Wu F, Chao J, Liu P, Hu G, Zhang JH, Yao H
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Jan 3;38(1):32-50
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Jan 3;38(1):32-50
Carnosic acid prevents COL1A2 transcription through the reduction of Smad3 acetylation via the AMPKα1/SIRT1 pathway.
Zhao Y, Shi X, Ding C, Feng D, Li Y, Hu Y, Wang L, Gao D, Tian X, Yao J
Toxicology and applied pharmacology 2018 Jan 15;339:172-180
Toxicology and applied pharmacology 2018 Jan 15;339:172-180
8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo.
Xiao Y, Tian C, Huang T, Han B, Wang M, Ma H, Li Z, Ye X, Li X
Life sciences 2018 Jan 1;192:259-269
Life sciences 2018 Jan 1;192:259-269
Hepatoprotective effects of ethyl pyruvate against CCl4-induced hepatic fibrosis via inhibition of TLR4/NF-κB signaling and up-regulation of MMPs/TIMPs ratio.
Zhang M, Hu X, Li S, Lu C, Li J, Zong Y, Qi W, Yang H
Clinics and research in hepatology and gastroenterology 2018 Feb;42(1):72-81
Clinics and research in hepatology and gastroenterology 2018 Feb;42(1):72-81
Epigallocatechin-3-gallate inhibits inflammation and epithelial‑mesenchymal transition through the PI3K/AKT pathway via upregulation of PTEN in asthma.
Yang N, Zhang H, Cai X, Shang Y
International journal of molecular medicine 2018 Feb;41(2):818-828
International journal of molecular medicine 2018 Feb;41(2):818-828
Toxoplasma gondii GRA15(II) effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica.
Xie Y, Wen H, Yan K, Wang S, Wang X, Chen J, Li Y, Xu Y, Zhong Z, Shen J, Chu D
Cellular & molecular immunology 2018 Feb;15(2):120-134
Cellular & molecular immunology 2018 Feb;15(2):120-134
Nanoplatform Assembled from a CD44-Targeted Prodrug and Smart Liposomes for Dual Targeting of Tumor Microenvironment and Cancer Cells.
Lv Y, Xu C, Zhao X, Lin C, Yang X, Xin X, Zhang L, Qin C, Han X, Yang L, He W, Yin L
ACS nano 2018 Feb 27;12(2):1519-1536
ACS nano 2018 Feb 27;12(2):1519-1536
Metformin attenuates motility, contraction, and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase.
Li Z, Ding Q, Ling LP, Wu Y, Meng DX, Li X, Zhang CQ
World journal of gastroenterology 2018 Feb 21;24(7):819-832
World journal of gastroenterology 2018 Feb 21;24(7):819-832
Sirt1 activation prevents anti-Thy 1.1 mesangial proliferative glomerulonephritis in the rat through the Nrf2/ARE pathway.
Huang K, Li R, Wei W
European journal of pharmacology 2018 Aug 5;832:138-144
European journal of pharmacology 2018 Aug 5;832:138-144
Chemokine (C-X-C motif) ligand 1 is associated with tumor progression and poor prognosis in patients with colorectal cancer.
Zhuo C, Wu X, Li J, Hu D, Jian J, Chen C, Zheng X, Yang C
Bioscience reports 2018 Aug 31;38(4)
Bioscience reports 2018 Aug 31;38(4)
Lipopolysaccharide enhances TGF-β1 signalling pathway and rat pancreatic fibrosis.
Sun L, Xiu M, Wang S, Brigstock DR, Li H, Qu L, Gao R
Journal of cellular and molecular medicine 2018 Apr;22(4):2346-2356
Journal of cellular and molecular medicine 2018 Apr;22(4):2346-2356
Inhibition of lysyl oxidase-like 1 (LOXL1) expression arrests liver fibrosis progression in cirrhosis by reducing elastin crosslinking.
Zhao W, Yang A, Chen W, Wang P, Liu T, Cong M, Xu A, Yan X, Jia J, You H
Biochimica et biophysica acta. Molecular basis of disease 2018 Apr;1864(4 Pt A):1129-1137
Biochimica et biophysica acta. Molecular basis of disease 2018 Apr;1864(4 Pt A):1129-1137
Upregulation of phosphatase and tensin homolog is essential for the effect of 4-aminopyridine on A549/CDDP cells.
Luo Z, Wang J, Li C, Qiu Y, Huang J, Huang Y, Gu H, Wu B, Hu Z, Zhen Y
Molecular medicine reports 2018 Apr;17(4):5996-6001
Molecular medicine reports 2018 Apr;17(4):5996-6001
Inhibition of tumor-promoting stroma to enforce subsequently targeting AT(1)R on tumor cells by pathological inspired micelles.
Zhu Y, Wen L, Shao S, Tan Y, Meng T, Yang X, Liu Y, Liu X, Yuan H, Hu F
Biomaterials 2018 Apr;161:33-46
Biomaterials 2018 Apr;161:33-46
Protective effects of yangonin from an edible botanical Kava against lithocholic acid-induced cholestasis and hepatotoxicity.
Kong Y, Gao X, Wang C, Ning C, Liu K, Liu Z, Sun H, Ma X, Sun P, Meng Q
European journal of pharmacology 2018 Apr 5;824:64-71
European journal of pharmacology 2018 Apr 5;824:64-71
5-aminoisoquinoline improves renal function and fibrosis during recovery phase of cisplatin-induced acute kidney injury in rats.
Quesada A, O'Valle F, Montoro-Molina S, Gómez-Morales M, Caba-Molina M, González JF, de Gracia MC, Osuna A, Vargas F, Wangensteen R
Bioscience reports 2018 Apr 27;38(2)
Bioscience reports 2018 Apr 27;38(2)
Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats.
Pei Z, Hu J, Bai Q, Liu B, Cheng D, Liu H, Na R, Yu Q
RSC advances 2018 Apr 17;8(26):14633-14639
RSC advances 2018 Apr 17;8(26):14633-14639
Serum levels of WNT1-inducible signaling pathway protein-1 (WISP-1): a noninvasive biomarker of renal fibrosis in subjects with chronic kidney disease.
Zhong X, Tu YJ, Li Y, Zhang P, Wang W, Chen SS, Li L, Chung AC, Lan HY, Chen HY, Li GS, Wang L
American journal of translational research 2017;9(6):2920-2932
American journal of translational research 2017;9(6):2920-2932
Carnosic Acid Alleviates BDL-Induced Liver Fibrosis through miR-29b-3p-Mediated Inhibition of the High-Mobility Group Box 1/Toll-Like Receptor 4 Signaling Pathway in Rats.
Zhang S, Wang Z, Zhu J, Xu T, Zhao Y, Zhao H, Tang F, Li Z, Zhou J, Gao D, Tian X, Yao J
Frontiers in pharmacology 2017;8:976
Frontiers in pharmacology 2017;8:976
Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes.
Liu J, Li Y, Liu L, Wang Z, Shi C, Cheng Z, Zhang X, Ding F, Chen PS
Frontiers in physiology 2017;8:291
Frontiers in physiology 2017;8:291
Gypenosides Ameliorate Carbon Tetrachloride-Induced Liver Fibrosis by Inhibiting the Differentiation of Hepatic Progenitor Cells into Myofibroblasts.
Chen J, Li X, Hu Y, Liu W, Zhou Q, Zhang H, Mu Y, Liu P
The American journal of Chinese medicine 2017;45(5):1061-1074
The American journal of Chinese medicine 2017;45(5):1061-1074
Effects of Total Flavone from Rhododendron simsii Planch. Flower on Postischemic Cardiac Dysfunction and Cardiac Remodeling in Rats.
Cheng X, Zhang J, Chen Z
Evidence-based complementary and alternative medicine : eCAM 2017;2017:5389272
Evidence-based complementary and alternative medicine : eCAM 2017;2017:5389272
Anti-OSM Antibody Inhibits Tubulointerstitial Lesion in a Murine Model of Lupus Nephritis.
Liu Q, Du Y, Li K, Zhang W, Feng X, Hao J, Li H, Liu S
Mediators of inflammation 2017;2017:3038514
Mediators of inflammation 2017;2017:3038514
Recombined human endostatin (Endostar) enhances cisplatin delivery and potentiates chemotherapy by decompressing colorectal cancer vessels.
Zhao X, Pan J, Song Y, Ding H, Qin L, Pan Y
International journal of clinical and experimental pathology 2017;10(11):10792-10801
International journal of clinical and experimental pathology 2017;10(11):10792-10801
Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
Xu L, Yin L, Tao X, Qi Y, Han X, Xu Y, Song S, Li L, Sun P, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):318-328
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):318-328
Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation.
Yu Z, Zhao S, Ren L, Wang L, Chen Z, Hoffman RM, Zhou J
Oncotarget 2017 Sep 8;8(38):63461-63483
Oncotarget 2017 Sep 8;8(38):63461-63483
The Hemoglobin Homolog Cytoglobin in Smooth Muscle Inhibits Apoptosis and Regulates Vascular Remodeling.
Jourd'heuil FL, Xu H, Reilly T, McKellar K, El Alaoui C, Steppich J, Liu YF, Zhao W, Ginnan R, Conti D, Lopez-Soler R, Asif A, Keller RK, Schwarz JJ, Thanh Thuy LT, Kawada N, Long X, Singer HA, Jourd'heuil D
Arteriosclerosis, thrombosis, and vascular biology 2017 Oct;37(10):1944-1955
Arteriosclerosis, thrombosis, and vascular biology 2017 Oct;37(10):1944-1955
High doses of baicalin induces kidney injury and fibrosis through regulating TGF-β/Smad signaling pathway.
Cai Y, Ma W, Xiao Y, Wu B, Li X, Liu F, Qiu J, Zhang G
Toxicology and applied pharmacology 2017 Oct 15;333:1-9
Toxicology and applied pharmacology 2017 Oct 15;333:1-9
Inhibition of airway remodeling and inflammation by isoforskolin in PDGF-induced rat ASMCs and OVA-induced rat asthma model.
Liang X, Wang J, Chen W, Ma X, Wang Y, Nagao N, Weng W, Huang J, Liu J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:275-286
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:275-286
Codelivery for Paclitaxel and Bcl-2 Conversion Gene by PHB-PDMAEMA Amphiphilic Cationic Copolymer for Effective Drug Resistant Cancer Therapy.
Wang X, Liow SS, Wu Q, Li C, Owh C, Li Z, Loh XJ, Wu YL
Macromolecular bioscience 2017 Nov;17(11)
Macromolecular bioscience 2017 Nov;17(11)
Effect of pioglitazone on the calcification of rat vascular smooth muscle cells through the downregulation of the Wnt/β‑catenin signaling pathway.
Gao M, Chen T, Wu L, Zhao X, Mao H, Xing C
Molecular medicine reports 2017 Nov;16(5):6208-6213
Molecular medicine reports 2017 Nov;16(5):6208-6213
Crocetin inhibits the proliferation, migration and TGF-β(2)-induced epithelial-mesenchymal transition of retinal pigment epithelial cells.
Wang HF, Ma JX, Shang QL, An JB, Chen HT
European journal of pharmacology 2017 Nov 15;815:391-398
European journal of pharmacology 2017 Nov 15;815:391-398
Galectin-3 mediates the pulmonary arterial hypertension-induced right ventricular remodeling through interacting with NADPH oxidase 4.
He J, Li X, Luo H, Li T, Zhao L, Qi Q, Liu Y, Yu Z
Journal of the American Society of Hypertension : JASH 2017 May;11(5):275-289.e2
Journal of the American Society of Hypertension : JASH 2017 May;11(5):275-289.e2
Production of human mutant biologically active hepatocyte growth factor in Chinese hamster ovary cells.
Xu D, Wan A, Peng L, Chen Y, He Y, Yang J, Jin J
Preparative biochemistry & biotechnology 2017 May 28;47(5):489-495
Preparative biochemistry & biotechnology 2017 May 28;47(5):489-495
FAM3B mediates high glucose-induced vascular smooth muscle cell proliferation and migration via inhibition of miR-322-5p.
Zhang W, Chen S, Zhang Z, Wang C, Liu C
Scientific reports 2017 May 23;7(1):2298
Scientific reports 2017 May 23;7(1):2298
Role of heparin in pulmonary cell populations in an in-vitro model of acute lung injury.
Camprubí-Rimblas M, Guillamat-Prats R, Lebouvier T, Bringué J, Chimenti L, Iglesias M, Obiols C, Tijero J, Blanch L, Artigas A
Respiratory research 2017 May 10;18(1):89
Respiratory research 2017 May 10;18(1):89
Highly Selective Targeting of Hepatic Stellate Cells for Liver Fibrosis Treatment Using a d-Enantiomeric Peptide Ligand of Fn14 Identified by Mirror-Image mRNA Display.
Huang L, Xie J, Bi Q, Li Z, Liu S, Shen Q, Li C
Molecular pharmaceutics 2017 May 1;14(5):1742-1753
Molecular pharmaceutics 2017 May 1;14(5):1742-1753
Reactive oxygen species mediate angiotensin II-induced transcytosis of low-density lipoprotein across endothelial cells.
Bian F, Cui J, Zheng T, Jin S
International journal of molecular medicine 2017 Mar;39(3):629-635
International journal of molecular medicine 2017 Mar;39(3):629-635
Generation and characteristics of human Sertoli cell line immortalized by overexpression of human telomerase.
Wen L, Yuan Q, Sun M, Niu M, Wang H, Fu H, Zhou F, Yao C, Wang X, Li Z, He Z
Oncotarget 2017 Mar 7;8(10):16553-16570
Oncotarget 2017 Mar 7;8(10):16553-16570
Dual Function for Mature Vascular Smooth Muscle Cells During Arteriovenous Fistula Remodeling.
Zhao J, Jourd'heuil FL, Xue M, Conti D, Lopez-Soler RI, Ginnan R, Asif A, Singer HA, Jourd'heuil D, Long X
Journal of the American Heart Association 2017 Mar 30;6(4)
Journal of the American Heart Association 2017 Mar 30;6(4)
Secreted phospholipase A2 of Clonorchis sinensis activates hepatic stellate cells through a pathway involving JNK signalling.
Wu Y, Li Y, Shang M, Jian Y, Wang C, Bardeesi AS, Li Z, Chen T, Zhao L, Zhou L, He A, Huang Y, Lv Z, Yu X, Li X
Parasites & vectors 2017 Mar 16;10(1):147
Parasites & vectors 2017 Mar 16;10(1):147
Losartan Attenuates Scar Formation in Filtering Bleb After Trabeculectomy.
Shi H, Wang H, Fu S, Xu K, Zhang X, Xiao Y, Ye W
Investigative ophthalmology & visual science 2017 Mar 1;58(3):1478-1486
Investigative ophthalmology & visual science 2017 Mar 1;58(3):1478-1486
miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions.
Cui H, Ge J, Xie N, Banerjee S, Zhou Y, Liu RM, Thannickal VJ, Liu G
American journal of physiology. Lung cellular and molecular physiology 2017 Mar 1;312(3):L415-L424
American journal of physiology. Lung cellular and molecular physiology 2017 Mar 1;312(3):L415-L424
NUBPL, a novel metastasis-related gene, promotes colorectal carcinoma cell motility by inducing epithelial-mesenchymal transition.
Wang Y, Wu N, Sun D, Sun H, Tong D, Liu D, Pang B, Li S, Wei J, Dai J, Liu Y, Bai J, Geng J, Fu S, Jin Y
Cancer science 2017 Jun;108(6):1169-1176
Cancer science 2017 Jun;108(6):1169-1176
LncRNA-ATB/microRNA-200a/β-catenin regulatory axis involved in the progression of HCV-related hepatic fibrosis.
Fu N, Zhao SX, Kong LB, Du JH, Ren WG, Han F, Zhang QS, Li WC, Cui P, Wang RQ, Zhang YG, Nan YM
Gene 2017 Jun 30;618:1-7
Gene 2017 Jun 30;618:1-7
Clonorchis sinensis lysophospholipase A upregulates IL-25 expression in macrophages as a potential pathway to liver fibrosis.
Zhou L, Shi M, Zhao L, Lin Z, Tang Z, Sun H, Chen T, Lv Z, Xu J, Huang Y, Yu X
Parasites & vectors 2017 Jun 17;10(1):295
Parasites & vectors 2017 Jun 17;10(1):295
Qi-Zhu-Xie-Zhuo-Fang reduces serum uric acid levels and ameliorates renal fibrosis in hyperuricemic nephropathy rats.
Huijuan W, Xiaoxu C, Rui S, Xinghui L, Beibei T, Jianchun M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jul;91:358-365
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jul;91:358-365
CYP2J2 metabolites, epoxyeicosatrienoic acids, attenuate Ang II-induced cardiac fibrotic response by targeting Gα(12/13).
He Z, Yang Y, Wen Z, Chen C, Xu X, Zhu Y, Wang Y, Wang DW
Journal of lipid research 2017 Jul;58(7):1338-1353
Journal of lipid research 2017 Jul;58(7):1338-1353
Conjugation of gold nanoparticles and recombinant human endostatin modulates vascular normalization via interruption of anterior gradient 2-mediated angiogenesis.
Pan F, Yang W, Li W, Yang XY, Liu S, Li X, Zhao X, Ding H, Qin L, Pan Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317708547
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317708547
Knockdown of histidine-rich calcium-binding protein (HRC) suppresses liver fibrosis by inhibiting the activation of hepatic stellate cells.
Liu J, Li M, Gong J, Han P, Wang Y, Li D, Tian D, Liao J
Biology open 2017 Jan 15;6(1):29-34
Biology open 2017 Jan 15;6(1):29-34
Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor.
Duan X, Meng Q, Wang C, Liu Z, Liu Q, Sun H, Sun P, Yang X, Huo X, Peng J, Liu K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Feb 15;25:83-92
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Feb 15;25:83-92
Interaction network of coexpressed mRNA, miRNA, and lncRNA activated by TGF‑β1 regulates EMT in human pulmonary epithelial cell.
Liu H, Zhao X, Xiang J, Zhang J, Meng C, Zhang J, Li M, Song X, Lv C
Molecular medicine reports 2017 Dec;16(6):8045-8054
Molecular medicine reports 2017 Dec;16(6):8045-8054
Morin enhances hepatic Nrf2 expression in a liver fibrosis rat model.
Sang L, Wang XM, Xu DY, Sang LX, Han Y, Jiang LY
World journal of gastroenterology 2017 Dec 21;23(47):8334-8344
World journal of gastroenterology 2017 Dec 21;23(47):8334-8344
Atrial natriuretic peptide: A novel mediator for TGF-β1-induced epithelial-mesenchymal transition in 16HBE-14o and A549 cells.
Chu S, Zhang X, Sun Y, Yu Y, Liang Y, Jiang M, Huang J, Ma L
Peptides 2017 Apr;90:1-9
Peptides 2017 Apr;90:1-9
The role of metastasis-associated in colon cancer 1 (MACC1) in endometrial carcinoma tumorigenesis and progression.
Chen S, Zong ZH, Wu DD, Sun KX, Liu BL, Zhao Y
Molecular carcinogenesis 2017 Apr;56(4):1361-1371
Molecular carcinogenesis 2017 Apr;56(4):1361-1371
MicroRNA-99a inhibits insulin-induced proliferation, migration, dedifferentiation, and rapamycin resistance of vascular smooth muscle cells by inhibiting insulin-like growth factor-1 receptor and mammalian target of rapamycin.
Zhang ZW, Guo RW, Lv JL, Wang XM, Ye JS, Lu NH, Liang X, Yang LX
Biochemical and biophysical research communications 2017 Apr 29;486(2):414-422
Biochemical and biophysical research communications 2017 Apr 29;486(2):414-422
MDM2 mediates fibroblast activation and renal tubulointerstitial fibrosis via a p53-independent pathway.
Ye C, Tang H, Zhao Z, Lei CT, You CQ, Zhang J, Gao P, He FF, Chen S, Wang YM, Zhang C, Su H
American journal of physiology. Renal physiology 2017 Apr 1;312(4):F760-F768
American journal of physiology. Renal physiology 2017 Apr 1;312(4):F760-F768
Inflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- Mice.
Wu W, Zhao L, Yang P, Zhou W, Li B, Moorhead JF, Varghese Z, Ruan XZ, Chen Y
PloS one 2016;11(7):e0159512
PloS one 2016;11(7):e0159512
Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy.
Li J, Chen K, Li S, Feng J, Liu T, Wang F, Zhang R, Xu S, Zhou Y, Zhou S, Xia Y, Lu J, Zhou Y, Guo C
Drug design, development and therapy 2016;10:619-30
Drug design, development and therapy 2016;10:619-30
MAD2B promotes tubular epithelial-to-mesenchymal transition and renal tubulointerstitial fibrosis via Skp2.
Tang H, Fan D, Lei CT, Ye C, Gao P, Chen S, Meng XF, Su H, Zhang C
Journal of molecular medicine (Berlin, Germany) 2016 Nov;94(11):1297-1307
Journal of molecular medicine (Berlin, Germany) 2016 Nov;94(11):1297-1307
A comparison of incidences of bladder neck contracture of 80- versus 180-W GreenLight laser photoselective vaporization of benign prostatic hyperplasia.
Hu B, Song Z, Liu H, Qiao L, Zhao Y, Wang M, Song W, Zhang D, Jin X, Zhang H
Lasers in medical science 2016 Nov;31(8):1573-1581
Lasers in medical science 2016 Nov;31(8):1573-1581
Tet methylcytosine dioxygenase 2 inhibits atherosclerosis via upregulation of autophagy in ApoE-/- mice.
Peng J, Yang Q, Li AF, Li RQ, Wang Z, Liu LS, Ren Z, Zheng XL, Tang XQ, Li GH, Tang ZH, Jiang ZS, Wei DH
Oncotarget 2016 Nov 22;7(47):76423-76436
Oncotarget 2016 Nov 22;7(47):76423-76436
IL-27 inhibits the TGF-β1-induced epithelial-mesenchymal transition in alveolar epithelial cells.
Dong Z, Tai W, Lei W, Wang Y, Li Z, Zhang T
BMC cell biology 2016 Mar 1;17:7
BMC cell biology 2016 Mar 1;17:7
Lymph node metastasis of primary endometrial cancers: Associated proteins revealed by MALDI imaging.
Mittal P, Klingler-Hoffmann M, Arentz G, Winderbaum L, Lokman NA, Zhang C, Anderson L, Scurry J, Leung Y, Stewart CJ, Carter J, Kaur G, Oehler MK, Hoffmann P
Proteomics 2016 Jun;16(11-12):1793-801
Proteomics 2016 Jun;16(11-12):1793-801
MicroRNA-548a-5p promotes proliferation and inhibits apoptosis in hepatocellular carcinoma cells by targeting Tg737.
Zhao G, Wang T, Huang QK, Pu M, Sun W, Zhang ZC, Ling R, Tao KS
World journal of gastroenterology 2016 Jun 21;22(23):5364-73
World journal of gastroenterology 2016 Jun 21;22(23):5364-73
Carboxy-terminal modulator protein attenuated extracellular matrix deposit by inhibiting phospho-Akt, TGF-β1 and α-SMA in kidneys of diabetic mice.
Chen N, Hao J, Li L, Li F, Liu S, Duan H
Biochemical and biophysical research communications 2016 Jun 10;474(4):753-760
Biochemical and biophysical research communications 2016 Jun 10;474(4):753-760
In vitro differentiation of endometrial regenerative cells into smooth muscle cells: Α potential approach for the management of pelvic organ prolapse.
Chen X, Kong X, Liu D, Gao P, Zhang Y, Li P, Liu M
International journal of molecular medicine 2016 Jul;38(1):95-104
International journal of molecular medicine 2016 Jul;38(1):95-104
Gold Nanoparticle-Mediated Targeted Delivery of Recombinant Human Endostatin Normalizes Tumour Vasculature and Improves Cancer Therapy.
Li W, Zhao X, Du B, Li X, Liu S, Yang XY, Ding H, Yang W, Pan F, Wu X, Qin L, Pan Y
Scientific reports 2016 Jul 29;6:30619
Scientific reports 2016 Jul 29;6:30619
Effect of astragalus injection on renal tubular epithelial transdifferentiation in type 2 diabetic mice.
Yi YE, Li SY, Nie YN, Jia DX, Zhang ZH, Wang YF, Wang Q
BMC complementary and alternative medicine 2016 Jul 16;16:222
BMC complementary and alternative medicine 2016 Jul 16;16:222
Clonorchis sinensis lysophospholipase inhibits TGF-β1-induced expression of pro-fibrogenic genes through attenuating the activations of Smad3, JNK2, and ERK1/2 in hepatic stellate cell line LX-2.
Zhou L, Shang M, Shi M, Zhao L, Lin Z, Chen T, Wu Y, Tang Z, Sun H, Yu J, Huang Y, Yu X
Parasitology research 2016 Feb;115(2):643-50
Parasitology research 2016 Feb;115(2):643-50
Mesenchymal stem cell-conditioned media suppresses inflammation-associated overproliferation of pulmonary artery smooth muscle cells in a rat model of pulmonary hypertension.
Liu J, Han Z, Han Z, He Z
Experimental and therapeutic medicine 2016 Feb;11(2):467-475
Experimental and therapeutic medicine 2016 Feb;11(2):467-475
Apobec-1 Complementation Factor (A1CF) Inhibits Epithelial-Mesenchymal Transition and Migration of Normal Rat Kidney Proximal Tubular Epithelial Cells.
Huang L, Wang H, Zhou Y, Ni D, Hu Y, Long Y, Liu J, Peng R, Zhou L, Liu Z, Lyu Z, Mao Z, Hao J, Li Y, Zhou Q
International journal of molecular sciences 2016 Feb 2;17(2)
International journal of molecular sciences 2016 Feb 2;17(2)
PTP1B confers liver fibrosis by regulating the activation of hepatic stellate cells.
Chen PJ, Cai SP, Yang Y, Li WX, Huang C, Meng XM, Li J
Toxicology and applied pharmacology 2016 Feb 1;292:8-18
Toxicology and applied pharmacology 2016 Feb 1;292:8-18
IL-27 attenuates the TGF-β1-induced proliferation, differentiation and collagen synthesis in lung fibroblasts.
Dong Z, Zhao X, Tai W, Lei W, Wang Y, Li Z, Zhang T
Life sciences 2016 Feb 1;146:24-33
Life sciences 2016 Feb 1;146:24-33
Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress.
Shi H, Shi A, Dong L, Lu X, Wang Y, Zhao J, Dai F, Guo X
Clinical nutrition (Edinburgh, Scotland) 2016 Dec;35(6):1366-1373
Clinical nutrition (Edinburgh, Scotland) 2016 Dec;35(6):1366-1373
miR-1273g-3p modulates activation and apoptosis of hepatic stellate cells by directly targeting PTEN in HCV-related liver fibrosis.
Niu X, Fu N, Du J, Wang R, Wang Y, Zhao S, Du H, Wang B, Zhang Y, Sun D, Nan Y
FEBS letters 2016 Aug;590(16):2709-24
FEBS letters 2016 Aug;590(16):2709-24
Quantitative Proteomic Analysis of Escherichia coli Heat-Labile Toxin B Subunit (LTB) with Enterovirus 71 (EV71) Subunit VP1.
Liu L, Ma Y, Zhou H, Wu M
International journal of molecular sciences 2016 Aug 27;17(9)
International journal of molecular sciences 2016 Aug 27;17(9)
The germline-enriched Ppp1r36 promotes autophagy.
Zhang Q, Gao M, Zhang Y, Song Y, Cheng H, Zhou R
Scientific reports 2016 Apr 21;6:24609
Scientific reports 2016 Apr 21;6:24609
C1q/tumor necrosis factor-related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting myofibroblast differentiation.
Lei H, Wu D, Wang JY, Li L, Zhang CL, Feng H, Fu FY, Wu LL
Basic research in cardiology 2015;110(4):35
Basic research in cardiology 2015;110(4):35
Valsartan Promoting Atherosclerotic Plaque Stabilization by Upregulating Renalase: A Potential-Related Gene of Atherosclerosis.
Zhou M, Ma C, Liu W, Liu H, Wang N, Kang Q, Li P
Journal of cardiovascular pharmacology and therapeutics 2015 Sep;20(5):509-19
Journal of cardiovascular pharmacology and therapeutics 2015 Sep;20(5):509-19
Ghrelin Attenuates Liver Fibrosis through Regulation of TGF-β1 Expression and Autophagy.
Mao Y, Zhang S, Yu F, Li H, Guo C, Fan X
International journal of molecular sciences 2015 Sep 10;16(9):21911-30
International journal of molecular sciences 2015 Sep 10;16(9):21911-30
Stroma derived COL6A3 is a potential prognosis marker of colorectal carcinoma revealed by quantitative proteomics.
Qiao J, Fang CY, Chen SX, Wang XQ, Cui SJ, Liu XH, Jiang YH, Wang J, Zhang Y, Yang PY, Liu F
Oncotarget 2015 Oct 6;6(30):29929-46
Oncotarget 2015 Oct 6;6(30):29929-46
CD73 regulates vascular smooth muscle cell functions and facilitates atherosclerotic plaque formation.
Yang J, Jian R, Yu J, Zhi X, Liao X, Yu J, Zhou P
IUBMB life 2015 Nov;67(11):853-60
IUBMB life 2015 Nov;67(11):853-60
Transarterial chemoembolization aggravated peritumoral fibrosis via hypoxia-inducible factor-1α dependent pathway in hepatocellular carcinoma.
Qu K, Yan Z, Wu Y, Chen Y, Qu P, Xu X, Yuan P, Huang X, Xing J, Zhang H, Liu C, Zhang J
Journal of gastroenterology and hepatology 2015 May;30(5):925-32
Journal of gastroenterology and hepatology 2015 May;30(5):925-32
Irradiated fibroblasts promote epithelial-mesenchymal transition and HDGF expression of esophageal squamous cell carcinoma.
Bao CH, Wang XT, Ma W, Wang NN, Un Nesa E, Wang JB, Wang C, Jia YB, Wang K, Tian H, Cheng YF
Biochemical and biophysical research communications 2015 Mar 6;458(2):441-7
Biochemical and biophysical research communications 2015 Mar 6;458(2):441-7
miR-494 suppresses the progression of breast cancer in vitro by targeting CXCR4 through the Wnt/β-catenin signaling pathway.
Song L, Liu D, Wang B, He J, Zhang S, Dai Z, Ma X, Wang X
Oncology reports 2015 Jul;34(1):525-31
Oncology reports 2015 Jul;34(1):525-31
CTRP3 attenuates post-infarct cardiac fibrosis by targeting Smad3 activation and inhibiting myofibroblast differentiation.
Wu D, Lei H, Wang JY, Zhang CL, Feng H, Fu FY, Li L, Wu LL
Journal of molecular medicine (Berlin, Germany) 2015 Dec;93(12):1311-25
Journal of molecular medicine (Berlin, Germany) 2015 Dec;93(12):1311-25
Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction.
Baba I, Egi Y, Utsumi H, Kakimoto T, Suzuki K
Molecular medicine reports 2015 Dec;12(6):8010-20
Molecular medicine reports 2015 Dec;12(6):8010-20
Anti-pulmonary fibrotic activity of salvianolic acid B was screened by a novel method based on the cyto-biophysical properties.
Liu M, Zheng M, Xu H, Liu L, Li Y, Xiao W, Li J, Ma E
Biochemical and biophysical research communications 2015 Dec 4-11;468(1-2):214-20
Biochemical and biophysical research communications 2015 Dec 4-11;468(1-2):214-20
Human Parechovirus 3 Meningitis and Fatal Leukoencephalopathy.
Bissel SJ, Auer RN, Chiang CH, Kofler J, Murdoch GH, Nix WA, Painter M, Richer M, Sartelet H, Wang G, Wiley CA
Journal of neuropathology and experimental neurology 2015 Aug;74(8):767-77
Journal of neuropathology and experimental neurology 2015 Aug;74(8):767-77
Beta-casomorphin-7 prevents epithelial-mesenchymal transdifferentiation of NRK-52E cells at high glucose level: Involvement of AngII-TGF-β1 pathway.
Zhang W, Song S, Liu F, Liu Y, Zhang Y
Peptides 2015 Aug;70:37-44
Peptides 2015 Aug;70:37-44
Involvement of cAMP-PKA pathway in adenosine A1 and A2A receptor-mediated regulation of acetaldehyde-induced activation of HSCs.
Yang Y, Wang H, Lv X, Wang Q, Zhao H, Yang F, Yang Y, Li J
Biochimie 2015 Aug;115:59-70
Biochimie 2015 Aug;115:59-70
Hesperetin derivative-7 inhibits PDGF-BB-induced hepatic stellate cell activation and proliferation by targeting Wnt/β-catenin pathway.
Lin X, Kong LN, Huang C, Ma TT, Meng XM, He Y, Wang QQ, Li J
International immunopharmacology 2015 Apr;25(2):311-20
International immunopharmacology 2015 Apr;25(2):311-20
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
Rosiglitazone inhibits TGF-β 1 induced activation of human Tenon fibroblasts via p38 signal pathway.
Luo YH, Ouyang PB, Tian J, Guo XJ, Duan XC
PloS one 2014;9(8):e105796
PloS one 2014;9(8):e105796
Regulating inflammation using acid-responsive electrospun fibrous scaffolds for skin scarless healing.
Yuan Z, Zhao J, Chen Y, Yang Z, Cui W, Zheng Q
Mediators of inflammation 2014;2014:858045
Mediators of inflammation 2014;2014:858045
Endoplasmic reticulum stress-induced hepatic stellate cell apoptosis through calcium-mediated JNK/P38 MAPK and Calpain/Caspase-12 pathways.
Huang Y, Li X, Wang Y, Wang H, Huang C, Li J
Molecular and cellular biochemistry 2014 Sep;394(1-2):1-12
Molecular and cellular biochemistry 2014 Sep;394(1-2):1-12
Association between the hypomethylation of osteopontin and integrin β3 promoters and vascular smooth muscle cell phenotype switching in great saphenous varicose veins.
Jiang H, Lun Y, Wu X, Xia Q, Zhang X, Xin S, Zhang J
International journal of molecular sciences 2014 Oct 17;15(10):18747-61
International journal of molecular sciences 2014 Oct 17;15(10):18747-61
Identification of colonic fibroblast secretomes reveals secretory factors regulating colon cancer cell proliferation.
Chen SX, Xu XE, Wang XQ, Cui SJ, Xu LL, Jiang YH, Zhang Y, Yan HB, Zhang Q, Qiao J, Yang PY, Liu F
Journal of proteomics 2014 Oct 14;110:155-71
Journal of proteomics 2014 Oct 14;110:155-71
Upregulation of let-7a inhibits vascular smooth muscle cell proliferation in vitro and in vein graft intimal hyperplasia in rats.
Cao H, Hu X, Zhang Q, Wang J, Li J, Liu B, Shao Y, Li X, Zhang J, Xin S
The Journal of surgical research 2014 Nov;192(1):223-33
The Journal of surgical research 2014 Nov;192(1):223-33
Overexpression of c1q/tumor necrosis factor-related protein-3 promotes phosphate-induced vascular smooth muscle cell calcification both in vivo and in vitro.
Zhou Y, Wang JY, Feng H, Wang C, Li L, Wu D, Lei H, Li H, Wu LL
Arteriosclerosis, thrombosis, and vascular biology 2014 May;34(5):1002-10
Arteriosclerosis, thrombosis, and vascular biology 2014 May;34(5):1002-10
Participation of miR-200a in TGF-β1-mediated hepatic stellate cell activation.
Sun X, He Y, Ma TT, Huang C, Zhang L, Li J
Molecular and cellular biochemistry 2014 Mar;388(1-2):11-23
Molecular and cellular biochemistry 2014 Mar;388(1-2):11-23
Effects and mechanism of dehydroepiandrosterone on epithelial-mesenchymal transition in bronchial epithelial cells.
Xu L, Xiang X, Ji X, Wang W, Luo M, Luo S, Li K, Gong S, Liu S, Ma L, Chen P, Li J
Experimental lung research 2014 Jun;40(5):211-21
Experimental lung research 2014 Jun;40(5):211-21
Hyperthermia-conditioned OECs serum-free-conditioned medium induce NSC differentiation into neuron more efficiently by the upregulation of HIF-1 alpha and binding activity.
Wang L, Jiang M, Duan D, Zhao Z, Ge L, Teng X, Liu B, Liu B, Chen P, Lu M
Transplantation 2014 Jun 27;97(12):1225-32
Transplantation 2014 Jun 27;97(12):1225-32
Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats.
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Toxicology letters 2014 Jan 13;224(2):175-85
Toxicology letters 2014 Jan 13;224(2):175-85
Antifibrotic effect of curcumin in TGF-β 1-induced myofibroblasts from human oral mucosa.
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Asian Pacific journal of cancer prevention : APJCP 2012;13(1):289-94
Asian Pacific journal of cancer prevention : APJCP 2012;13(1):289-94
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Cellular signalling 2012 Oct;24(10):1923-30
Cellular signalling 2012 Oct;24(10):1923-30
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Peptides 2012 Aug;36(2):186-91
Fusion between cancer cells and myofibroblasts is involved in osteosarcoma.
Yu L, Guo W, Zhao S, Wang F, Xu Y
Oncology letters 2011 Nov;2(6):1083-1087
Oncology letters 2011 Nov;2(6):1083-1087
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The Journal of biological chemistry 2004 Sep 3;279(36):37436-44
The Journal of biological chemistry 2004 Sep 3;279(36):37436-44
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human placenta tissue were subjected to SDS PAGE followed by western blot with 14395-1-AP(ACTA2 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-ACTA2 (IP:14395-1-AP, 3ug; Detection:14395-1-AP 1:1000) with mouse liver tissue lysate 6000ug.
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human hysteromyoma using 14395-1-AP(ACTA2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ACTA2/smooth muscle actin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ACTA2/smooth muscle actin. This antibody recognizes human,mouse,rat antigen. The ACTA2/smooth muscle actin antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
