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- Antibody Data
- Antigen structure
- References [32]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 23081-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- smooth muscle actin antibody
- Antibody type
- Polyclonal
- Description
- smooth muscle actin antibody (Cat. #23081-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Time-restricted feeding has a limited effect on hepatic lipid accumulation, inflammation and fibrosis in a choline-deficient high-fat diet-induced murine NASH model.
FLNB overexpression promotes tumor progression and associates with immune suppression, evasion and stemness in pancreatic cancer.
CircUTRN24/miR-483-3p/IGF-1 Regulates Autophagy Mediated Liver Fibrosis in Biliary Atresia.
Calcitriol ameliorates the progression of hepatic fibrosis through autophagy-related gene 16-like 1-mediated autophagy.
MiR-552-3p Regulates Multiple Fibrotic and Inflammatory genes Concurrently in Hepatic Stellate Cells Improving NASH-associated Phenotypes.
SIRT2 Deficiency Aggravates Diet-Induced Nonalcoholic Fatty Liver Disease through Modulating Gut Microbiota and Metabolites.
A new liver regeneration molecular mechanism involving hepatic stellate cells, Kupffer cells, and glucose-regulated protein 78 as a new hepatotrophic factor.
Senile plaques in Alzheimer's disease arise from Aβ- and Cathepsin D-enriched mixtures leaking out during intravascular haemolysis and microaneurysm rupture.
Keloid Patient Plasma-Derived Exosomal hsa_circ_0020792 Promotes Normal Skin Fibroblasts Proliferation, Migration, and Fibrogenesis via Modulating miR-193a-5p and Activating TGF-β1/Smad2/3 Signaling.
Developmentally interdependent stretcher-compressor relationship between the embryonic brain and the surrounding scalp in the preosteogenic head.
Depiction of Aging-Based Molecular Phenotypes With Diverse Clinical Prognosis and Immunological Features in Gastric Cancer.
A Novel End-to-End Biliary-to-Biliary Anastomosis Technique for Iatrogenic Bile Duct Injury of Strasberg-Bismuth E1-4 Treatment: A Retrospective Study and in vivo Assessment.
Development and Characterization of Alkaline Phosphatase-Positive Human Umbilical Cord Perivascular Cells.
HMGB1-activated fibroblasts promote breast cancer cells metastasis via RAGE/aerobic glycolysis.
Plasma levels of trimethylamine-N-oxide can be increased with 'healthy' and 'unhealthy' diets and do not correlate with the extent of atherosclerosis but with plaque instability.
MicroRNA-520c-3p targeting of RelA/p65 suppresses atherosclerotic plaque formation.
Polystyrene microplastics cause granulosa cells apoptosis and fibrosis in ovary through oxidative stress in rats.
Citri reticulatae Pericarpium attenuates Ang II-induced pathological cardiac hypertrophy via upregulating peroxisome proliferator-activated receptors gamma.
Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth.
Polystyrene microplastics cause cardiac fibrosis by activating Wnt/β-catenin signaling pathway and promoting cardiomyocyte apoptosis in rats.
The AKT inhibitor MK2206 suppresses airway inflammation and the pro‑remodeling pathway in a TDI‑induced asthma mouse model.
AKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformations.
Locus Coeruleus Degeneration Induces Forebrain Vascular Pathology in a Transgenic Rat Model of Alzheimer's Disease.
Reticulocalbin 2 enhances osteogenic differentiation of human vascular smooth muscle cells in diabetic conditions.
Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injury.
Carnosol-mediated Sirtuin 1 activation inhibits Enhancer of Zeste Homolog 2 to attenuate liver fibrosis.
Establishment of two ovarian cancer orthotopic xenograft mouse models for in vivo imaging: A comparative study.
The anti-fibrotic effects of microRNA-153 by targeting TGFBR-2 in pulmonary fibrosis.
Inhibitory effects of long noncoding RNA MEG3 on hepatic stellate cells activation and liver fibrogenesis.
Effect of the vascular endothelial growth factor expression level on angiopoietin-2-mediated nasopharyngeal carcinoma growth.
Musashi2 predicts poor prognosis and invasion in hepatocellular carcinoma by driving epithelial-mesenchymal transition.
The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension.
Sato T, Oishi K
PloS one 2024;19(1):e0296950
PloS one 2024;19(1):e0296950
FLNB overexpression promotes tumor progression and associates with immune suppression, evasion and stemness in pancreatic cancer.
Fan G, Yan Q, Chen Y, Han M, Wu Z, Ruan S, Zhuang H, Gou Q, Hou B
American journal of cancer research 2024;14(2):709-726
American journal of cancer research 2024;14(2):709-726
CircUTRN24/miR-483-3p/IGF-1 Regulates Autophagy Mediated Liver Fibrosis in Biliary Atresia.
Liu D, Wu Z, Gao J, Mei Q, Zhang X, Wang B
Molecular biotechnology 2024 Jun;66(6):1424-1433
Molecular biotechnology 2024 Jun;66(6):1424-1433
Calcitriol ameliorates the progression of hepatic fibrosis through autophagy-related gene 16-like 1-mediated autophagy.
Guo E, Yuan H, Li R, Yang J, Liu S, Liu A, Jiang X
The American journal of the medical sciences 2024 Jun;367(6):382-396
The American journal of the medical sciences 2024 Jun;367(6):382-396
MiR-552-3p Regulates Multiple Fibrotic and Inflammatory genes Concurrently in Hepatic Stellate Cells Improving NASH-associated Phenotypes.
Ma N, Hou A, Pan X, Sun F, Xu X, Yu C, Lai R, Huang R, Gong L, Xie Q, Chen J, Ren J
International journal of biological sciences 2023;19(11):3456-3471
International journal of biological sciences 2023;19(11):3456-3471
SIRT2 Deficiency Aggravates Diet-Induced Nonalcoholic Fatty Liver Disease through Modulating Gut Microbiota and Metabolites.
Li X, Du Y, Xue C, Kang X, Sun C, Peng H, Fang L, Han Y, Xu X, Zhao C
International journal of molecular sciences 2023 May 18;24(10)
International journal of molecular sciences 2023 May 18;24(10)
A new liver regeneration molecular mechanism involving hepatic stellate cells, Kupffer cells, and glucose-regulated protein 78 as a new hepatotrophic factor.
Hagiwara K, Harimoto N, Yamanaka T, Ishii N, Yokobori T, Tsukagoshi M, Watanabe A, Araki K, Yoshizumi T, Shirabe K
Journal of hepato-biliary-pancreatic sciences 2023 Feb;30(2):165-176
Journal of hepato-biliary-pancreatic sciences 2023 Feb;30(2):165-176
Senile plaques in Alzheimer's disease arise from Aβ- and Cathepsin D-enriched mixtures leaking out during intravascular haemolysis and microaneurysm rupture.
Fu H, Li J, Du P, Jin W, Gao G, Cui D
FEBS letters 2023 Apr;597(7):1007-1040
FEBS letters 2023 Apr;597(7):1007-1040
Keloid Patient Plasma-Derived Exosomal hsa_circ_0020792 Promotes Normal Skin Fibroblasts Proliferation, Migration, and Fibrogenesis via Modulating miR-193a-5p and Activating TGF-β1/Smad2/3 Signaling.
Hu H, Mao G, Zheng J, Guo F
Drug design, development and therapy 2022;16:4223-4234
Drug design, development and therapy 2022;16:4223-4234
Developmentally interdependent stretcher-compressor relationship between the embryonic brain and the surrounding scalp in the preosteogenic head.
Tsujikawa K, Saito K, Nagasaka A, Miyata T
Developmental dynamics : an official publication of the American Association of Anatomists 2022 Jul;251(7):1107-1122
Developmental dynamics : an official publication of the American Association of Anatomists 2022 Jul;251(7):1107-1122
Depiction of Aging-Based Molecular Phenotypes With Diverse Clinical Prognosis and Immunological Features in Gastric Cancer.
He F, Ding H, Zhou Y, Wang Y, Xie J, Yang S, Zhu Y
Frontiers in medicine 2021;8:792740
Frontiers in medicine 2021;8:792740
A Novel End-to-End Biliary-to-Biliary Anastomosis Technique for Iatrogenic Bile Duct Injury of Strasberg-Bismuth E1-4 Treatment: A Retrospective Study and in vivo Assessment.
Ma D, Liu P, Lan J, Chen B, Gu Y, Li Y, Yue P, Liu Z, Guo D
Frontiers in surgery 2021;8:747304
Frontiers in surgery 2021;8:747304
Development and Characterization of Alkaline Phosphatase-Positive Human Umbilical Cord Perivascular Cells.
Nonoyama S, Karakida T, Chiba-Ohkuma R, Yamamoto R, Ujiie Y, Nagano T, Yamakoshi Y, Gomi K
Cells 2021 Nov 4;10(11)
Cells 2021 Nov 4;10(11)
HMGB1-activated fibroblasts promote breast cancer cells metastasis via RAGE/aerobic glycolysis.
Chen Y, Cai L, Guo X, Li Z, Liao X, Zhang X, Huang L, He J
Neoplasma 2021 Jan;68(1):71-78
Neoplasma 2021 Jan;68(1):71-78
Plasma levels of trimethylamine-N-oxide can be increased with 'healthy' and 'unhealthy' diets and do not correlate with the extent of atherosclerosis but with plaque instability.
Koay YC, Chen YC, Wali JA, Luk AWS, Li M, Doma H, Reimark R, Zaldivia MTK, Habtom HT, Franks AE, Fusco-Allison G, Yang J, Holmes A, Simpson SJ, Peter K, O'Sullivan JF
Cardiovascular research 2021 Jan 21;117(2):435-449
Cardiovascular research 2021 Jan 21;117(2):435-449
MicroRNA-520c-3p targeting of RelA/p65 suppresses atherosclerotic plaque formation.
Wang J, Hu X, Hu X, Gao F, Li M, Cui Y, Wei X, Qin Y, Zhang C, Zhao Y, Gao Y
The international journal of biochemistry & cell biology 2021 Feb;131:105873
The international journal of biochemistry & cell biology 2021 Feb;131:105873
Polystyrene microplastics cause granulosa cells apoptosis and fibrosis in ovary through oxidative stress in rats.
An R, Wang X, Yang L, Zhang J, Wang N, Xu F, Hou Y, Zhang H, Zhang L
Toxicology 2021 Feb 15;449:152665
Toxicology 2021 Feb 15;449:152665
Citri reticulatae Pericarpium attenuates Ang II-induced pathological cardiac hypertrophy via upregulating peroxisome proliferator-activated receptors gamma.
Ni G, Wang K, Zhou Y, Wu X, Wang J, Shang H, Wang L, Li X
Annals of translational medicine 2020 Sep;8(17):1064
Annals of translational medicine 2020 Sep;8(17):1064
Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth.
Krivanek J, Soldatov RA, Kastriti ME, Chontorotzea T, Herdina AN, Petersen J, Szarowska B, Landova M, Matejova VK, Holla LI, Kuchler U, Zdrilic IV, Vijaykumar A, Balic A, Marangoni P, Klein OD, Neves VCM, Yianni V, Sharpe PT, Harkany T, Metscher BD, Bajénoff M, Mina M, Fried K, Kharchenko PV, Adameyko I
Nature communications 2020 Sep 23;11(1):4816
Nature communications 2020 Sep 23;11(1):4816
Polystyrene microplastics cause cardiac fibrosis by activating Wnt/β-catenin signaling pathway and promoting cardiomyocyte apoptosis in rats.
Li Z, Zhu S, Liu Q, Wei J, Jin Y, Wang X, Zhang L
Environmental pollution (Barking, Essex : 1987) 2020 Oct;265(Pt A):115025
Environmental pollution (Barking, Essex : 1987) 2020 Oct;265(Pt A):115025
The AKT inhibitor MK2206 suppresses airway inflammation and the pro‑remodeling pathway in a TDI‑induced asthma mouse model.
Cui H, Cheng Y, He Y, Cheng W, Zhao W, Zhao H, Zhou FH, Wang L, Dong J, Cai S
Molecular medicine reports 2020 Nov;22(5):3723-3734
Molecular medicine reports 2020 Nov;22(5):3723-3734
AKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformations.
Si Y, Huang J, Li X, Fu Y, Xu R, Du Y, Cheng J, Jiang H
Cell communication and signaling : CCS 2020 Aug 31;18(1):139
Cell communication and signaling : CCS 2020 Aug 31;18(1):139
Locus Coeruleus Degeneration Induces Forebrain Vascular Pathology in a Transgenic Rat Model of Alzheimer's Disease.
Kelly SC, McKay EC, Beck JS, Collier TJ, Dorrance AM, Counts SE
Journal of Alzheimer's disease : JAD 2019;70(2):371-388
Journal of Alzheimer's disease : JAD 2019;70(2):371-388
Reticulocalbin 2 enhances osteogenic differentiation of human vascular smooth muscle cells in diabetic conditions.
Chang Z, Yan G, Yan H, Zheng J, Liu Z
Life sciences 2019 Sep 15;233:116746
Life sciences 2019 Sep 15;233:116746
Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injury.
Cui H, Banerjee S, Guo S, Xie N, Ge J, Jiang D, Zörnig M, Thannickal VJ, Liu G
JCI insight 2019 Feb 21;4(4)
JCI insight 2019 Feb 21;4(4)
Carnosol-mediated Sirtuin 1 activation inhibits Enhancer of Zeste Homolog 2 to attenuate liver fibrosis.
Zhao H, Wang Z, Tang F, Zhao Y, Feng D, Li Y, Hu Y, Wang C, Zhou J, Tian X, Yao J
Pharmacological research 2018 Feb;128:327-337
Pharmacological research 2018 Feb;128:327-337
Establishment of two ovarian cancer orthotopic xenograft mouse models for in vivo imaging: A comparative study.
Guo J, Cai J, Zhang Y, Zhu Y, Yang P, Wang Z
International journal of oncology 2017 Oct;51(4):1199-1208
International journal of oncology 2017 Oct;51(4):1199-1208
The anti-fibrotic effects of microRNA-153 by targeting TGFBR-2 in pulmonary fibrosis.
Liang C, Li X, Zhang L, Cui D, Quan X, Yang W
Experimental and molecular pathology 2015 Oct;99(2):279-85
Experimental and molecular pathology 2015 Oct;99(2):279-85
Inhibitory effects of long noncoding RNA MEG3 on hepatic stellate cells activation and liver fibrogenesis.
He Y, Wu YT, Huang C, Meng XM, Ma TT, Wu BM, Xu FY, Zhang L, Lv XW, Li J
Biochimica et biophysica acta 2014 Nov;1842(11):2204-15
Biochimica et biophysica acta 2014 Nov;1842(11):2204-15
Effect of the vascular endothelial growth factor expression level on angiopoietin-2-mediated nasopharyngeal carcinoma growth.
Chen HH, Weng BQ, Cheng KJ, Liu HY, Wang SQ, Lu YY
Vascular cell 2014 Mar 1;6(1):4
Vascular cell 2014 Mar 1;6(1):4
Musashi2 predicts poor prognosis and invasion in hepatocellular carcinoma by driving epithelial-mesenchymal transition.
He L, Zhou X, Qu C, Hu L, Tang Y, Zhang Q, Liang M, Hong J
Journal of cellular and molecular medicine 2014 Jan;18(1):49-58
Journal of cellular and molecular medicine 2014 Jan;18(1):49-58
The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension.
Fan YF, Zhang R, Jiang X, Wen L, Wu DC, Liu D, Yuan P, Wang YL, Jing ZC
Cardiovascular research 2013 Aug 1;99(3):395-403
Cardiovascular research 2013 Aug 1;99(3):395-403
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse heart tissue were subjected to SDS PAGE followed by western blot with 23081-1-AP(ACTA2 antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The ACTA2/smooth muscle actin antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ACTA2/smooth muscle actin. This antibody recognizes human, mouse antigen. The ACTA2/smooth muscle actin antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human heart using 23081-1-AP(ACTA2 antibody) at dilution of 1:500 (under 40x lens)
- Sample type
- tissue
