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- Antigen structure
- References [13]
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- Western blot [1]
- Immunoprecipitation [1]
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- Product number
- 22802-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- CCS antibody
- Antibody type
- Polyclonal
- Description
- CCS antibody (Cat. #22802-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Distinct signaling mechanisms and proteome phenotypes are elicited by compartment-specific genetic defects of copper homeostasis.
Elesclomol-Induced Copper Influx Attenuates Lung Adenocarcinoma Progression With Involvement of the ER Stress/PCK2 Axis.
Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.
Disruption of NF-κB-Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis.
Copper Chaperone for Superoxide Dismutase Subtypes as a Prognostic Marker in Luminal B Breast Cancer.
Rationally designed catalytic nanoplatform for enhanced chemoimmunotherapy via deploying endogenous plus exogenous copper and remodeling tumor microenvironment.
The E3 ligase TRIM22 functions as a tumor suppressor in breast cancer by targeting CCS for proteasomal degradation to inhibit STAT3 signaling.
Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.
Artemether ameliorates adriamycin induced cardiac atrophy in mice.
AMPK phosphorylates and stabilises copper transporter 1 to synergise metformin and copper chelator for breast cancer therapy.
The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease.
Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.
S-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects.
Lane AR, Gonzalez N, Gokhale A, Zlatic SA, Allen BM, Scher NE, Roberts AM, Duong DM, Roberts BR, Vrailas-Mortimer AD, Werner E, Faundez V
bioRxiv : the preprint server for biology 2026 Jan 14;
bioRxiv : the preprint server for biology 2026 Jan 14;
Elesclomol-Induced Copper Influx Attenuates Lung Adenocarcinoma Progression With Involvement of the ER Stress/PCK2 Axis.
Zhao J, Chen Y, Lu D, Zeng Y, Li J, Zhu J, Lei Z, Huang JA, Liu Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Nov 30;39(22):e71250
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Nov 30;39(22):e71250
Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.
Lane AR, Scher NE, Bhattacharjee S, Zlatic SA, Roberts AM, Gokhale A, Singleton KS, Duong DM, McKenna M, Liu WL, Baiju A, Moctezuma FGR, Tran T, Patel AA, Clayton LB, Petris MJ, Wood LB, Patgiri A, Vrailas-Mortimer AD, Cox DN, Roberts BR, Werner E, Faundez V
Molecular biology of the cell 2025 Mar 1;36(3):ar33
Molecular biology of the cell 2025 Mar 1;36(3):ar33
Disruption of NF-κB-Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis.
Zhang X, Su Y, Yang W, Song Z, Sun Z, Wu X, Chen J, Gao B, Wang Z, Wang L, Jiang Q, Bu L, Li J, Lin Y, Xie W, Li J, Guo J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e06201
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e06201
Copper Chaperone for Superoxide Dismutase Subtypes as a Prognostic Marker in Luminal B Breast Cancer.
Li Y, Du W, Yang R, Wei X, Li H, Zhang X
Clinical Medicine Insights. Oncology 2024;18:11795549231219239
Clinical Medicine Insights. Oncology 2024;18:11795549231219239
Rationally designed catalytic nanoplatform for enhanced chemoimmunotherapy via deploying endogenous plus exogenous copper and remodeling tumor microenvironment.
Sun D, Yu L, Wang G, Xu Y, Wang P, Wang N, Wu Z, Zhang G, Zhang J, Zhang Y, Tian G, Wei P
Journal of nanobiotechnology 2024 Sep 9;22(1):551
Journal of nanobiotechnology 2024 Sep 9;22(1):551
The E3 ligase TRIM22 functions as a tumor suppressor in breast cancer by targeting CCS for proteasomal degradation to inhibit STAT3 signaling.
Yang Y, Hao X, Zhang J, Gao T, Huo M, Liu W, Hu T, Ma T, Yuan B, Zhang M, Teng X, Yu H, Huang W, Wang Y
Cancer letters 2024 Sep 28;600:217157
Cancer letters 2024 Sep 28;600:217157
Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration.
Lane AR, Scher NE, Bhattacharjee S, Zlatic SA, Roberts AM, Gokhale A, Singleton KS, Duong DM, McKenna M, Liu WL, Baiju A, Moctezuma FGR, Tran T, Patel AA, Clayton LB, Petris MJ, Wood LB, Patgiri A, Vrailas-Mortimer AD, Cox DN, Roberts BR, Werner E, Faundez V
bioRxiv : the preprint server for biology 2024 Nov 18;
bioRxiv : the preprint server for biology 2024 Nov 18;
Artemether ameliorates adriamycin induced cardiac atrophy in mice.
Weng W, Yu X, Dong Y, Wang T, Shao M, Sun H, Han P
Molecular medicine reports 2023 Aug;28(2)
Molecular medicine reports 2023 Aug;28(2)
AMPK phosphorylates and stabilises copper transporter 1 to synergise metformin and copper chelator for breast cancer therapy.
Zhang X, Jiang Q, Su Y, Bu L, Sun Z, Wu X, Gao B, Wang L, Lin Y, Xie W, Guo J
British journal of cancer 2023 Apr;128(8):1452-1465
British journal of cancer 2023 Apr;128(8):1452-1465
The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease.
Bakkar N, Starr A, Rabichow BE, Lorenzini I, McEachin ZT, Kraft R, Chaung M, Macklin-Isquierdo S, Wingfield T, Carhart B, Zahler N, Chang WH, Bassell GJ, Betourne A, Boulis N, Alworth SV, Ichida JK, August PR, Zarnescu DC, Sattler R, Bowser R
Neurobiology of disease 2021 Feb;149:105228
Neurobiology of disease 2021 Feb;149:105228
Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.
Singh RP, Jeyaraju DV, Voisin V, Hurren R, Xu C, Hawley JR, Barghout SH, Khan DH, Gronda M, Wang X, Jitkova Y, Sharon D, Liyanagae S, MacLean N, Seneviratene AK, Mirali S, Borenstein A, Thomas GE, Soriano J, Orouji E, Minden MD, Arruda A, Chan SM, Bader GD, Lupien M, Schimmer AD
Cell stem cell 2020 Jun 4;26(6):926-937.e10
Cell stem cell 2020 Jun 4;26(6):926-937.e10
S-acylation of SOD1, CCS, and a stable SOD1-CCS heterodimer in human spinal cords from ALS and non-ALS subjects.
Antinone SE, Ghadge GD, Ostrow LW, Roos RP, Green WN
Scientific reports 2017 Jan 25;7:41141
Scientific reports 2017 Jan 25;7:41141
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 22802-1-AP(CCS antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CCS antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human CCS. This antibody recognizes human antigen. The CCS antibody has been validated for the following applications: ELISA, WB, IP analysis.
