NCKIPSD

The protein encoded by this gene contains a nuclear localization signal. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation This protein is involved in the formation and maintenance of dendritic spines, and modulates synaptic activity in neurons. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2019]

Description

NCK interacting protein with SH3 domain

Tissue specificity

Tissue enhanced (parathyroid gland)

Subcell location

Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3:p21.31 (48673844 - 48686364)

Ensembl ID

ENSG00000213672  (ver. 103.38)

Orthologs

Mouse Nckipsd: ENSMUSG00000032598

UniProt

Q9NZQ3

neXtProt

NX_Q9NZQ3

Human splice variants
Mouse splice variants